Hyoung Gon Ko

Summary

Affiliation: Seoul National University
Country: Korea

Publications

  1. pmc Null effect of antidepressants on the astrocytes-mediated proliferation of hippocampal progenitor cells in vitro
    Hyoung Gon Ko
    National Creative Research Initiative Center for Memory and Institute of Molecular Biology and Genetics, Department of Biological Sciences, College of Natural Sciences, Seoul National University, Gwanak Gu, Seoul, Korea
    Mol Pain 3:16. 2007
  2. pmc Effect of ablated hippocampal neurogenesis on the formation and extinction of contextual fear memory
    Hyoung Gon Ko
    National Creative Research Initiative Center for Memory, Department of Biological Sciences, College of Natural Sciences, Seoul National University, San 56 1 Silim dong, Gwanak Gu, Seoul, 151 747, Korea
    Mol Brain 2:1. 2009
  3. ncbi request reprint Plasticity of metabotropic glutamate receptor-dependent long-term depression in the anterior cingulate cortex after amputation
    SukJae Joshua Kang
    Department of Brain and Cognitive Sciences, College of Natural Sciences, Seoul National University, Seoul 151 746, Korea
    J Neurosci 32:11318-29. 2012
  4. pmc PKA-activated ApAF-ApC/EBP heterodimer is a key downstream effector of ApCREB and is necessary and sufficient for the consolidation of long-term facilitation
    Jin A Lee
    Institute of Molecular Biology and Genetics, Rio, Department of Biological Sciences, College of Natural Sciences, Seoul National University, Seoul 151 747, Korea
    J Cell Biol 174:827-38. 2006
  5. ncbi request reprint Assessment of the effects of virus-mediated limited Oct4 overexpression on the structure of the hippocampus and behavior in mice
    Su Eon Sim
    Brain and Cognitive Sciences, College of Natural Sciences, Seoul National University, Seoul 151 747, Korea
    BMB Rep 44:793-8. 2011
  6. pmc Reduced acute nociception and chronic pain in Shank2-/- mice
    Hyoung Gon Ko
    Department of Biological Sciences, College of Natural Sciences, Seoul National University, Seoul, Korea
    Mol Pain 12:. 2016
  7. doi request reprint The role of nuclear PKMζ in memory maintenance
    Hyoung Gon Ko
    School of Biological Sciences, College of Natural Sciences, Seoul National University, Seoul 08826, South Korea
    Neurobiol Learn Mem 135:50-56. 2016
  8. pmc AMPA receptor exchange underlies transient memory destabilization on retrieval
    Ingie Hong
    School of Biological Sciences, Seoul National University, Seoul 151 747, Korea
    Proc Natl Acad Sci U S A 110:8218-23. 2013
  9. doi request reprint PI3Kγ is required for NMDA receptor-dependent long-term depression and behavioral flexibility
    Jae Ick Kim
    National Creative Research Initiative Center for Memory, Department of Biological Sciences, College of Natural Sciences, Seoul National University, Seoul, Korea
    Nat Neurosci 14:1447-54. 2011
  10. doi request reprint Enhancing inhibitory synaptic function reverses spatial memory deficits in Shank2 mutant mice
    Chae Seok Lim
    Laboratory of Neurobiology, School of Biological Sciences, College of Natural Sciences, Seoul National University, Seoul, 08826, South Korea
    Neuropharmacology 112:104-112. 2017

Collaborators

Detail Information

Publications12

  1. pmc Null effect of antidepressants on the astrocytes-mediated proliferation of hippocampal progenitor cells in vitro
    Hyoung Gon Ko
    National Creative Research Initiative Center for Memory and Institute of Molecular Biology and Genetics, Department of Biological Sciences, College of Natural Sciences, Seoul National University, Gwanak Gu, Seoul, Korea
    Mol Pain 3:16. 2007
    ..It has been recently reported that astroglia induce the neurogenesis of the hippocampal neural progenitor cells (NPCs). Therefore, we hypothesized that antidepressants may act on astrocytes, and this in turn induces neurogenesis of NPCs...
  2. pmc Effect of ablated hippocampal neurogenesis on the formation and extinction of contextual fear memory
    Hyoung Gon Ko
    National Creative Research Initiative Center for Memory, Department of Biological Sciences, College of Natural Sciences, Seoul National University, San 56 1 Silim dong, Gwanak Gu, Seoul, 151 747, Korea
    Mol Brain 2:1. 2009
    ..These results suggest that although adult newborn neurons contribute to contextual fear memory, they may not be involved in the extinction or erasure of hippocampus-dependent contextual fear memory...
  3. ncbi request reprint Plasticity of metabotropic glutamate receptor-dependent long-term depression in the anterior cingulate cortex after amputation
    SukJae Joshua Kang
    Department of Brain and Cognitive Sciences, College of Natural Sciences, Seoul National University, Seoul 151 746, Korea
    J Neurosci 32:11318-29. 2012
    ..Our results provide in vitro evidence of the spatiotemporal properties of ACC LTD in adult mice. We demonstrate that tail amputation causes LTD impairment within the ACC circuit and that this can be rescued by activation of mGluR1...
  4. pmc PKA-activated ApAF-ApC/EBP heterodimer is a key downstream effector of ApCREB and is necessary and sufficient for the consolidation of long-term facilitation
    Jin A Lee
    Institute of Molecular Biology and Genetics, Rio, Department of Biological Sciences, College of Natural Sciences, Seoul National University, Seoul 151 747, Korea
    J Cell Biol 174:827-38. 2006
    ..Collectively, these results suggest that PKA-activated ApAF-ApC/EBP heterodimer is a core downstream effector of ApCREB in the consolidation of LTF...
  5. ncbi request reprint Assessment of the effects of virus-mediated limited Oct4 overexpression on the structure of the hippocampus and behavior in mice
    Su Eon Sim
    Brain and Cognitive Sciences, College of Natural Sciences, Seoul National University, Seoul 151 747, Korea
    BMB Rep 44:793-8. 2011
    ..This first trial for pluripotency induction in vivo, despite negative results, provides implications and information for future studies on in vivo cellular reprogramming...
  6. pmc Reduced acute nociception and chronic pain in Shank2-/- mice
    Hyoung Gon Ko
    Department of Biological Sciences, College of Natural Sciences, Seoul National University, Seoul, Korea
    Mol Pain 12:. 2016
    ..Thus, in this study, we used Shank2(-) (/) (-) (Shank2 knock-out, KO) mice to investigate the controversial pain sensitivity issue and found that Shank2 KO mice showed reduced tactile perception and analgesia to chronic pain. ..
  7. doi request reprint The role of nuclear PKMζ in memory maintenance
    Hyoung Gon Ko
    School of Biological Sciences, College of Natural Sciences, Seoul National University, Seoul 08826, South Korea
    Neurobiol Learn Mem 135:50-56. 2016
    ..Finally, we showed that the amnesic effect of PKMζ inhibition can be rescued by enhancing histone acetylation level. These results suggest the possibility that nuclear PKMζ has a crucial role in memory maintenance...
  8. pmc AMPA receptor exchange underlies transient memory destabilization on retrieval
    Ingie Hong
    School of Biological Sciences, Seoul National University, Seoul 151 747, Korea
    Proc Natl Acad Sci U S A 110:8218-23. 2013
    ..Taken together, our results reveal unexpected physiological roles of CI-AMPARs and CP-AMPARs in transforming a consolidated memory into an unstable memory and subsequently guiding reconsolidation...
  9. doi request reprint PI3Kγ is required for NMDA receptor-dependent long-term depression and behavioral flexibility
    Jae Ick Kim
    National Creative Research Initiative Center for Memory, Department of Biological Sciences, College of Natural Sciences, Seoul National University, Seoul, Korea
    Nat Neurosci 14:1447-54. 2011
    ..Thus, individual isoforms of PI3Ks may have distinct roles in different types of synaptic plasticity and may therefore influence various kinds of behavior...
  10. doi request reprint Enhancing inhibitory synaptic function reverses spatial memory deficits in Shank2 mutant mice
    Chae Seok Lim
    Laboratory of Neurobiology, School of Biological Sciences, College of Natural Sciences, Seoul National University, Seoul, 08826, South Korea
    Neuropharmacology 112:104-112. 2017
    ..This article is part of the Special Issue entitled 'Ionotropic glutamate receptors'...
  11. pmc Mildly Increased Mechanical Nociceptive Sensitivity in REV-ERBα Knock-out Mice
    Jaehyun Lee
    Department of Biological Sciences, College of Natural Sciences, Seoul National University, Seoul 08826, Korea
    Exp Neurobiol 25:342-346. 2016
    ..However, this partial alteration was independent of the circadian rhythm. Taken together, deletion of REV-ERBα induced a mild change in mechanical nociceptive sensitivity but this alteration was not dependent on the circadian rhythm...
  12. ncbi request reprint Nuclear translocation of CAM-associated protein activates transcription for long-term facilitation in Aplysia
    Seung Hee Lee
    Department of Biological Sciences, Institute of Molecular Biology and Genetics, Rio, College of Natural Sciences, Seoul National University, San 56 1 Silim dong Gwanak gu, Seoul 151 747, Korea
    Cell 129:801-12. 2007
    ..Combined, our data suggest that CAMAP is a retrograde signaling component that translocates from activated synapses to the nucleus during synapse-specific LTF...