W S Park

Summary

Affiliation: Samsung Medical Center
Country: Korea

Publications

  1. pmc Erythropoietin attenuates hyperoxia-induced lung injury by down-modulating inflammation in neonatal rats
    Jang Hoon Lee
    Department of Pediatrics, College of Medicine, Korea University, Seoul, Korea
    J Korean Med Sci 22:1042-7. 2007
  2. pmc Intratracheal administration of endotoxin attenuates hyperoxia-induced lung injury in neonatal rats
    Jae Won Shim
    Department of Pediatrics, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, 50 Ilwon Dong, Gangnam Gu, Seoul 135 710, Korea
    Yonsei Med J 49:144-50. 2008
  3. pmc Pretreatment with N-nitro-L-arginine methyl ester improved oxygenation after inhalation of nitric oxide in newborn piglets with Escherichia coli pneumonia and sepsis
    Yun Sil Chang
    Department of Pediatrics, Samsung Medical Center, 50 Ilwon Dong, Gangnam Gu, Seoul, Korea
    J Korean Med Sci 21:965-72. 2006
  4. pmc Comparison of clinical efficacy of Newfactan versus Surfacten for the treatment of respiratory distress syndrome in the newborn infants
    Chang Won Choi
    Department of Pediatrics, Samsung Seoul Hospital, Samsung Cheil Hospital, Korea
    J Korean Med Sci 20:591-7. 2005
  5. pmc A comparison of AmBisome to amphotericin B for treatment of systemic candidiasis in very low birth weight infants
    Ga Won Jeon
    Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Ilwon Dong, Kangnam Gu, Seoul 135 710, Korea
    Yonsei Med J 48:619-26. 2007
  6. ncbi request reprint The efficacy of pentoxifylline as an anti-inflammatory agent in experimental Escherichia coli meningitis in the newborn piglet
    W S Park
    Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
    Biol Neonate 77:236-42. 2000
  7. pmc Effects of decreased cerebral perfusion pressure on cerebral hemodynamics, brain cell membrane function and energy metabolism during the early phase of experimental Escherichia coli meningitis in the newborn piglet
    W S Park
    Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
    J Korean Med Sci 15:203-10. 2000
  8. ncbi request reprint 3-Aminobenzamide, a poly (ADP-ribose) synthetase inhibitor, attenuates the acute inflammatory responses and brain injury in experimental Escherichia coli meningitis in the newborn piglet
    W S Park
    Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
    Neurol Res 23:410-6. 2001
  9. pmc Effects of dopamine infusion on cerebral blood flow, brain cell membrane function and energy metabolism in experimental Escherichia coli meningitis in the newborn piglet
    Won Soon Park
    Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
    J Korean Med Sci 18:869-75. 2003
  10. ncbi request reprint Effect of alpha-phenyl-N-tert-butylnitrone on brain cell membrane function and energy metabolism in experimental Escherichia coli meningitis in the newborn piglet
    W S Park
    Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
    J Neurochem 74:763-9. 2000

Collaborators

Detail Information

Publications43

  1. pmc Erythropoietin attenuates hyperoxia-induced lung injury by down-modulating inflammation in neonatal rats
    Jang Hoon Lee
    Department of Pediatrics, College of Medicine, Korea University, Seoul, Korea
    J Korean Med Sci 22:1042-7. 2007
    ..In summary, rhEPO treatment significantly attenuated hyperoxia-induced lung injury by down-modulating the inflammatory responses in neonatal rats...
  2. pmc Intratracheal administration of endotoxin attenuates hyperoxia-induced lung injury in neonatal rats
    Jae Won Shim
    Department of Pediatrics, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, 50 Ilwon Dong, Gangnam Gu, Seoul 135 710, Korea
    Yonsei Med J 49:144-50. 2008
    ..This study was undertaken to determine the effects of intratracheal administration of endotoxin on hyperoxia-induced lung injury in neonatal rats...
  3. pmc Pretreatment with N-nitro-L-arginine methyl ester improved oxygenation after inhalation of nitric oxide in newborn piglets with Escherichia coli pneumonia and sepsis
    Yun Sil Chang
    Department of Pediatrics, Samsung Medical Center, 50 Ilwon Dong, Gangnam Gu, Seoul, Korea
    J Korean Med Sci 21:965-72. 2006
    ..This result suggests that a NOS blockade may be a possible supportive option for oxygenation by iNO treatment in neonatal Gram-negative bacterial pneumonia and sepsis...
  4. pmc Comparison of clinical efficacy of Newfactan versus Surfacten for the treatment of respiratory distress syndrome in the newborn infants
    Chang Won Choi
    Department of Pediatrics, Samsung Seoul Hospital, Samsung Cheil Hospital, Korea
    J Korean Med Sci 20:591-7. 2005
    ..We concluded that Newfactan was comparable to Surfacten in the clinical efficacy in the treatment of RDS in both birth weight groups...
  5. pmc A comparison of AmBisome to amphotericin B for treatment of systemic candidiasis in very low birth weight infants
    Ga Won Jeon
    Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Ilwon Dong, Kangnam Gu, Seoul 135 710, Korea
    Yonsei Med J 48:619-26. 2007
    ..This study investigated the safety and efficacy of AmBisome, a lipid formulation of amphotericin B containing liposomal structures, for the treatment of systemic candidiasis in very low birth weight infants (VLBWI)...
  6. ncbi request reprint The efficacy of pentoxifylline as an anti-inflammatory agent in experimental Escherichia coli meningitis in the newborn piglet
    W S Park
    Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
    Biol Neonate 77:236-42. 2000
    ....
  7. pmc Effects of decreased cerebral perfusion pressure on cerebral hemodynamics, brain cell membrane function and energy metabolism during the early phase of experimental Escherichia coli meningitis in the newborn piglet
    W S Park
    Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
    J Korean Med Sci 15:203-10. 2000
    ..In summary, decreased CPP observed in this study failed to induce cerebral ischemia and further brain injury, indicating that cerebrovascular autoregulation is intact during the early phase of experimental neonatal bacterial meningitis...
  8. ncbi request reprint 3-Aminobenzamide, a poly (ADP-ribose) synthetase inhibitor, attenuates the acute inflammatory responses and brain injury in experimental Escherichia coli meningitis in the newborn piglet
    W S Park
    Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
    Neurol Res 23:410-6. 2001
    ..These findings suggest that poly (ADP-ribose) synthetase inhibitors such as 3-aminobenzamide might be a promising novel anti-inflammatory and neuroprotective adjuvant therapy in neonatal bacterial meningitis...
  9. pmc Effects of dopamine infusion on cerebral blood flow, brain cell membrane function and energy metabolism in experimental Escherichia coli meningitis in the newborn piglet
    Won Soon Park
    Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
    J Korean Med Sci 18:869-75. 2003
    ..In summary, maintenance of adequate CPP with dopamine prevented cerebral ischemia, reduced cerebral energy depletion, and attenuated brain injury in neonatal bacterial meningitis...
  10. ncbi request reprint Effect of alpha-phenyl-N-tert-butylnitrone on brain cell membrane function and energy metabolism in experimental Escherichia coli meningitis in the newborn piglet
    W S Park
    Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
    J Neurochem 74:763-9. 2000
    ..These results suggest that although it failed to attenuate the inflammatory responses, alpha-phenyl-N-tert-butylnitrone was effective in ameliorating brain injury in neonatal bacterial meningitis...
  11. ncbi request reprint N(omega) -nitro-L-arginine methyl ester (L-NAME) attenuates the acute inflammatory responses and brain injury during the early phase of experimental Escherichia coli meningitis in the newborn piglet
    W S Park
    Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
    Neurol Res 23:862-8. 2001
    ..These findings suggest that L-NAME was effective in attenuating the acute inflammatory responses and brain injury in neonatal bacterial meningitis...
  12. pmc Effect of hypothermia on brain cell membrane function and energy metabolism after transient global hypoxia-ischemia in the newborn piglet
    W S Park
    Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
    J Korean Med Sci 16:335-41. 2001
    ..In summary, hypothermia applied immediately after HI for 4 hr did not improve the recovery of brain cell membrane function and energy metabolism in the newborn piglet...
  13. ncbi request reprint 7-Nitroindazole, but not aminoguanidine, attenuates the acute inflammatory responses and brain injury during the early phase of Escherichia coli meningitis in the newborn piglet
    W S Park
    Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
    Biol Neonate 80:53-9. 2001
    ..In summary, 7-nitroindazole, but not aminoguanidine, significantly attenuated the acute inflammatory responses and brain injury during the early phase of neonatal bacterial meningitis...
  14. ncbi request reprint Effects of hyperglycemia or hypoglycemia on brain cell membrane function and energy metabolism during the immediate reoxygenation-reperfusion period after acute transient global hypoxia-ischemia in the newborn piglet
    W S Park
    Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea
    Brain Res 901:102-8. 2001
    ..These findings suggest that post-hypoxic-ischemic hyperglycemia is not beneficial and might even be harmful in neonatal hypoxic-ischemic encephalopathy...
  15. ncbi request reprint Effect of hypothermia on brain cell membrane function and energy metabolism in experimental Escherichia coli meningitis in the newborn piglet
    W S Park
    Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
    Neurochem Res 26:369-74. 2001
    ..In summary, hypothermia significantly attenuated the acute inflammatory responses and the ensuing brain injury in experimental neonatal bacterial meningitis...
  16. ncbi request reprint Effect of hypothermia on bilirubin-induced alterations in brain cell membrane function and energy metabolism in newborn piglets
    W S Park
    Department of Pediatrics, Samsung Medical Center, 50 Ilwon Dong, Kangnam Gu, Sungkyunkwan University School of Medicine, Seoul, South Korea
    Brain Res 922:276-81. 2001
    ..These findings suggest the possibility that hypothermia could be a good neuroprotective therapeutic modality in neonatal bilirubin encephalopathy...
  17. ncbi request reprint A distinct tumor suppressor gene locus on chromosome 15q21.1 in sporadic form of colorectal cancer
    W S Park
    Department of Pathology and Cancer Research Institute, College of Medicine, The Catholic University of Korea, Seoul
    Cancer Res 60:70-3. 2000
    ..THBS1, 0.185 Mb proximal to D15S968, is the nearest known gene to this specific narrow loss of heterozygosity region. Thus, we speculate that THBS1 might be the most probable candidate gene involved in colorectal cancer carcinogenesis...
  18. ncbi request reprint Mutational analysis of JAK1 gene in human hepatocellular carcinoma
    H J Xie
    Department of Pathology, Microdisection Genomic Research Center, College of Medicine, The Catholic University of Korea, Seoul, Korea
    Neoplasma 56:136-40. 2009
    ..Although the functional assessment of this novel mutant remains to be completed, JAK1 mutation may contribute to the tumor development in liver cancer...
  19. ncbi request reprint Somatic mutations in the death domain of the Fas (Apo-1/CD95) gene in gastric cancer
    W S Park
    Department of Pathology and Cancer Research Institutes, College of Medicine, The Catholic University of Korea, Seoul 137-701, Korea
    J Pathol 193:162-8. 2001
    ....
  20. ncbi request reprint A simple, precise and economical microdissection technique for analysis of genomic DNA from archival tissue sections
    J Y Lee
    Department of Pathology and Cancer Research Institute, Catholic University Medical College, Seoul, Korea
    Virchows Arch 433:305-9. 1998
    ..The main advantages of this technique over the current methods lie in its simplicity, low cost, easy handling and precision...
  21. doi request reprint MicroRNA-29c functions as a tumor suppressor by direct targeting oncogenic SIRT1 in hepatocellular carcinoma
    H J Bae
    1 Laboratory of Oncogenomics, Department of Pathology, College of Medicine, Catholic University of Korea, Seoul, Republic of Korea 2 Functional RNomics Research Center, Catholic University of Korea, Seoul, Republic of Korea
    Oncogene 33:2557-67. 2014
    ..The loss or suppression of miR-29c may cause aberrant SIRT1 overexpression and promotes liver tumorigenesis. Overall, we suggest that miR-29c functions as a tumor suppressor by regulating abnormal SIRT1 activity in liver. ..
  22. ncbi request reprint The p53 codon 72 polymorphism and susceptibility to colorectal cancer in Korean patients
    Z Cao
    Department of Pathology, College of Medicine, The Catholic University of Korea, Seoul, Korea
    Neoplasma 56:114-8. 2009
    ..0459). The specific allele frequencies showed borderline significance (<em>p</em>=0.0502). Our findings suggest that the p53 Pro72 variant is associated with an increased risk for colorectal cancer in the Korean population...
  23. ncbi request reprint The Glu346Lys polymorphism and frameshift mutations of the Methyl-CpG Binding Domain 4 gene in gastrointestinal cancer
    J H Song
    Department of Pathology, College of Medicine, The Catholic University of Korea, Seoul, Korea
    Neoplasma 56:343-7. 2009
    ..Our findings suggest that microsatellite instability may not be associated with frameshift mutations in the MBD4 gene, and that the MBD4 codon 346 polymorphism may play arole in colorectal cancer susceptibility in the Korean population...
  24. pmc Changes in dead space/tidal volume ratio and pulmonary mechanics after surfactant replacement therapy in respiratory distress syndrome of the newborn infants
    E H Chung
    Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University, School of Medicine, Seoul, Korea
    J Korean Med Sci 16:51-6. 2001
    ....
  25. ncbi request reprint Overexpression of Wnt-2 in colorectal cancers
    J K Park
    Department of Surgery, College of Medicine, The Catholic University of Korea, Seoul, Korea
    Neoplasma 56:119-23. 2009
    ..05). These results indicate that up-regulation of the Wnt-2 protein might play a role in the development of colorectal cancers, as an early event of carcinogenesis...
  26. ncbi request reprint Low frequency mutation of the Ephrin receptor A3 gene in hepatocellular carcinoma
    H J Bae
    Department of Pathology, Microdissection Genomics Research Center, College of Medicine, The Catholic University of Korea, Seoul, Korea
    Neoplasma 56:331-4. 2009
    ..Although the functional assessments of this mutant are incomplete, it is believed that this novel EphA3 mutation may contribute to the development of hepatocellular carcinoma...
  27. pmc Effects of MK-801 (dizocilpine) on brain cell membrane function and energy metabolism in experimental Escherichia coli meningitis in the newborn piglet
    Sun Young Ko
    Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
    J Korean Med Sci 18:236-41. 2003
    ..These results suggest that MK-801 was effective in ameliorating brain injury in neonatal bacterial meningitis, although it failed to attenuate the inflammatory responses...
  28. ncbi request reprint Factors associated with immunoprophylaxis failure against vertical transmission of hepatitis B virus
    Yun Mi Song
    Department of Family Medicine, Samsung Medical Center, Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine, 50 Irwondong, Gangnamgu, Seoul, South Korea
    Eur J Pediatr 166:813-8. 2007
    ..To identify those children at high risk of HBV immunoprophylaxis failure, maternal HBeAg and HBV DNA need to be assessed prior to childbirth...
  29. pmc Combined effect of low-dose nitric oxide gas inhalation with partial liquid ventilation on hemodynamics, pulmonary function, and gas exchange in acute lung injury of newborn piglets
    Chang Won Choi
    Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
    J Korean Med Sci 18:813-20. 2003
    ..We concluded that NO might have a cumulative effect on gas exchange when combined with PLV, and this might be attributable to deceased PAP and V/Q mismatching...
  30. ncbi request reprint Effect of 7-nitroindazole on bilirubin-induced changes in brain cell membrane function and energy metabolism in newborn piglets
    Won Soon Park
    Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
    Biol Neonate 82:61-5. 2002
    ..These findings suggest that nitric oxide produced by nNOS is involved in mediating or facilitating bilirubin-induced cerebral dysfunction...
  31. pmc Effects of hypertonic (7%) saline on brain injury in experimental Escherichia coli meningitis
    Chang Won Choi
    Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
    J Korean Med Sci 20:870-6. 2005
    ..These findings implicate some attenuation of the meningitis-induced alterations in cerebral cortical cell membrane structure and function with HTS, possibly by improving CPP and attenuating acute inflammatory responses...
  32. pmc Effects of alpha-phenyl-N-tert-butyl nitrone (PBN)on brain cell membrane function and energy metabolism during transient global cerebral hypoxia-ischemia and reoxygenation-reperfusion in newborn piglets
    Chang Won Choi
    Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
    J Korean Med Sci 19:413-8. 2004
    ....
  33. pmc Deubiquitination of Dishevelled by Usp14 is required for Wnt signaling
    H Jung
    Department of Life Science, The University of Seoul, Seoul, Korea
    Oncogenesis 2:e64. 2013
    ..Consistently, tissue microarray analysis of colon cancer revealed a strong correlation between the levels of Usp14 and β-catenin, which suggests an oncogenic role for Usp14 via enhancement of Wnt/β-catenin signaling. ..
  34. ncbi request reprint A comparative study of corneal endothelial changes induced by different durations of soft contact lens wear
    J S Lee
    Department of Ophthalmology and Medical Research Institute, College of Medicine, Pusan National University, Korea
    Graefes Arch Clin Exp Ophthalmol 239:1-4. 2001
    ..To analyze the effect on the morphologic characteristics of the corneal endothelium of the duration of soft contact lens wearing periods...
  35. ncbi request reprint Nuclear localization of beta-catenin is an important prognostic factor in hepatoblastoma
    W S Park
    Department of Pathology and Cancer Research Institute, College of Medicine, The Catholic University of Korea, 505 Banpo-dong, Sacho-gu, Seoul 137-701, Korea
    J Pathol 193:483-90. 2001
    ..0090). It is therefore concluded that immunohistochemical analysis of beta-catenin might be a useful clinical tool for estimating the prognosis for patients with hepatoblastoma...
  36. ncbi request reprint CD99 regulates the transport of MHC class I molecules from the Golgi complex to the cell surface
    H W Sohn
    Department of. Pathology and Internal Medicine, Seoul National University College of Medicine, Seoul, Korea
    J Immunol 166:787-94. 2001
    ....
  37. pmc Effects of perfluorocarbon associated high frequency oscillatory ventilation on hemodynamics and gas exchange in the newborn piglets with respiratory distress
    Chang Won Choi
    Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
    J Korean Med Sci 18:663-8. 2003
    ..We concluded that the addition of 30 mL/kg of perfluorodecalin to HFOV showed no detrimental effect on hemodynamics, but did not produce a significant improvement in gas exchange over a three-hour period...
  38. pmc Detrimental effects of N(omega) nitro-L-arginine methyl ester (L-NAME)in experimental Escherichia coli sepsis in the newborn piglet
    Sung Shin Kim
    Department of Pediatrics, Bucheon Hospital, Soonchunhyang University, College of Medicine, Bucheon, Korea
    J Korean Med Sci 18:637-40. 2003
    ..These findings suggest that nonselective inhibition of nitric oxide synthase with L-NAME is detrimental during the early phase of experimental neonatal sepsis...
  39. doi request reprint Human umbilical cord blood-derived mesenchymal stem cells attenuate hyperoxia-induced lung injury in neonatal rats
    Yun Sil Chang
    Department of Pediatrics, Samsung Medical Center, Kangnam Gu, Seoul, Republic of Korea
    Cell Transplant 18:869-86. 2009
    ..In conclusion, intratracheal transplantation of human UCB-derived MSCs is more effective than intraperitoneal transplantation in attenuating the hyperoxia-induced lung injury in neonatal rats...
  40. pmc Therapeutic window for cycloheximide treatment after hypoxic-ischemic brain injury in neonatal rats
    Won Soon Park
    Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
    J Korean Med Sci 21:490-4. 2006
    ..In summary, cycloheximide was neuroprotective when given within 6 hr after HI in the developing newborn rat brain...
  41. pmc Erythropoietin attenuates brain injury, subventricular zone expansion, and sensorimotor deficits in hypoxic-ischemic neonatal rats
    Sung Shin Kim
    Department of Pediatrics, Soonchunhyang University College of Medicine, Bucheon Hospital, Buchoen, Korea
    J Korean Med Sci 23:484-91. 2008
    ..These results support the use of EPO as a candidate drug for treatment of neonatal hypoxic-ischemic brain damage...
  42. pmc Neuroprotective effect of cycloheximide on hypoxic-ischemic brain injury in neonatal rats
    Won Soon Park
    Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Gangnam Gu, Seoul, Korea
    J Korean Med Sci 21:337-41. 2006
    ....
  43. doi request reprint Alpha-phenyl-N-tert-butylnitrone attenuates hyperoxia-induced lung injury by down-modulating inflammation in neonatal rats
    Yun Sil Chang
    Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
    Exp Lung Res 35:234-49. 2009
    ..In summary, a spin-trapping agent PBN significantly attenuated hyperoxia-induced lung injury by down-regulating the inflammatory responses in neonatal rats...