Myung Shik Lee

Summary

Affiliation: Samsung Medical Center
Country: Korea

Publications

  1. ncbi request reprint IFN-gamma sensitizes MIN6N8 insulinoma cells to TNF-alpha-induced apoptosis by inhibiting NF-kappaB-mediated XIAP upregulation
    Hun Sik Kim
    Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea
    Biochem Biophys Res Commun 336:847-53. 2005
  2. ncbi request reprint Cytokine synergism in apoptosis: its role in diabetes and cancer
    Myung Shik Lee
    Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine and National Research Laboratory of Cell Death and Diabetes Research, Seoul 135 710, Korea
    J Biochem Mol Biol 35:54-60. 2002
  3. ncbi request reprint Fas is expressed in murine pancreatic islet cells and an insulinoma cell line but does not mediate their apoptosis in vitro
    M S Lee
    Department of Medicine, Samsung Medical Center, SungKyunKwan University Medical College, Seoul, Korea
    Autoimmunity 29:189-99. 1999
  4. ncbi request reprint Death effectors of beta-cell apoptosis in type 1 diabetes
    Myung Shik Lee
    Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Irwon dong Kangnam ku, Seoul 135 710, Republic of Korea
    Mol Genet Metab 83:82-92. 2004
  5. ncbi request reprint Resistance of rho(0) cells against apoptosis
    Myung Shik Lee
    Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Irwon dong Kangnam ku, Seoul 135 710, Korea
    Ann N Y Acad Sci 1011:146-53. 2004
  6. ncbi request reprint Insulin secretory defect plays a major role in the development of diabetes in patients with distal pancreatectomy
    Byung Wan Lee
    Division of Endocrinology and Metabolism, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 135 710, South Korea
    Metabolism 55:135-41. 2006
  7. ncbi request reprint The favorable outcome of human islet transplantation in Korea: experiences of 10 autologous transplantations
    Byung Wan Lee
    Division of Endocrinology and Metabolism, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 135 710, Korea
    Transplantation 79:1568-74. 2005
  8. ncbi request reprint Resistance of mitochondrial DNA-depleted cells against cell death: role of mitochondrial superoxide dismutase
    Sun Young Park
    Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Irwondong Kangnam ku, Seoul 135 710, Korea
    J Biol Chem 279:7512-20. 2004
  9. ncbi request reprint Nuclear factor kappaB protects pancreatic beta-cells from tumor necrosis factor-alpha-mediated apoptosis
    Inik Chang
    Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Irwon dong, Kangnam Ku, Seoul 135 710, Korea
    Diabetes 52:1169-75. 2003
  10. ncbi request reprint First human trial of pancreatic islet allo-transplantation in Korea--focus on re-transplantation
    Tae Young Yang
    Department of Medicine, Division of Endocrinology and Metabolism, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 135 710, South Korea
    Diabetes Res Clin Pract 56:107-13. 2002

Collaborators

Detail Information

Publications94

  1. ncbi request reprint IFN-gamma sensitizes MIN6N8 insulinoma cells to TNF-alpha-induced apoptosis by inhibiting NF-kappaB-mediated XIAP upregulation
    Hun Sik Kim
    Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea
    Biochem Biophys Res Commun 336:847-53. 2005
    ....
  2. ncbi request reprint Cytokine synergism in apoptosis: its role in diabetes and cancer
    Myung Shik Lee
    Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine and National Research Laboratory of Cell Death and Diabetes Research, Seoul 135 710, Korea
    J Biochem Mol Biol 35:54-60. 2002
    ..We also studied similar cytokine synergism in cancer cell deaths, and noted the similarities and dissimilarities between cancer cell death and islet cell death...
  3. ncbi request reprint Fas is expressed in murine pancreatic islet cells and an insulinoma cell line but does not mediate their apoptosis in vitro
    M S Lee
    Department of Medicine, Samsung Medical Center, SungKyunKwan University Medical College, Seoul, Korea
    Autoimmunity 29:189-99. 1999
    ..FasL transfectant cells also did not kill MIN6N8 cells. Our data indicate that pancreatic beta-islet cells express a small amount of Fas molecules but Fas molecules do not mediate apoptosis of islet cells at least in vitro...
  4. ncbi request reprint Death effectors of beta-cell apoptosis in type 1 diabetes
    Myung Shik Lee
    Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Irwon dong Kangnam ku, Seoul 135 710, Republic of Korea
    Mol Genet Metab 83:82-92. 2004
    ..Such participation of Ca2+ in beta-cell death appears to have a close relevance to the mitochondrial events or ER stress that constitutes an important part of cell death machinery recently identified...
  5. ncbi request reprint Resistance of rho(0) cells against apoptosis
    Myung Shik Lee
    Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Irwon dong Kangnam ku, Seoul 135 710, Korea
    Ann N Y Acad Sci 1011:146-53. 2004
    ....
  6. ncbi request reprint Insulin secretory defect plays a major role in the development of diabetes in patients with distal pancreatectomy
    Byung Wan Lee
    Division of Endocrinology and Metabolism, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 135 710, South Korea
    Metabolism 55:135-41. 2006
    ..In addition, the study suggests that pancreatic resections of 60% or less and body mass index are not the main causes of diabetes onset after d-Px in this study...
  7. ncbi request reprint The favorable outcome of human islet transplantation in Korea: experiences of 10 autologous transplantations
    Byung Wan Lee
    Division of Endocrinology and Metabolism, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 135 710, Korea
    Transplantation 79:1568-74. 2005
    ..Islet autotransplantation is a therapeutic approach used to prevent diabetes in cases of pathologically benign neoplasm after major pancreatectomy...
  8. ncbi request reprint Resistance of mitochondrial DNA-depleted cells against cell death: role of mitochondrial superoxide dismutase
    Sun Young Park
    Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Irwondong Kangnam ku, Seoul 135 710, Korea
    J Biol Chem 279:7512-20. 2004
    ....
  9. ncbi request reprint Nuclear factor kappaB protects pancreatic beta-cells from tumor necrosis factor-alpha-mediated apoptosis
    Inik Chang
    Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Irwon dong, Kangnam Ku, Seoul 135 710, Korea
    Diabetes 52:1169-75. 2003
    ..These results suggest the protective role of NF-kappaB activation against cytokine-mediated pancreatic beta-cell death, contrary to previous reports implicating NF-kappaB as a mediator of pancreatic islet cell death...
  10. ncbi request reprint First human trial of pancreatic islet allo-transplantation in Korea--focus on re-transplantation
    Tae Young Yang
    Department of Medicine, Division of Endocrinology and Metabolism, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 135 710, South Korea
    Diabetes Res Clin Pract 56:107-13. 2002
    ..The success of this re-transplantation is one step closer to becoming a viable alternative for the millions of individuals who are suffering from diabetes...
  11. doi request reprint Diabetes-free survival in patients who underwent islet autotransplantation after 50% to 60% distal partial pancreatectomy for benign pancreatic tumors
    Sang Man Jin
    Division of Endocrinology and Metabolism, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
    Transplantation 95:1396-403. 2013
    ....
  12. ncbi request reprint Resistance of mitochondrial DNA-deficient cells to TRAIL: role of Bax in TRAIL-induced apoptosis
    Ja Young Kim
    Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Irwon dong Kangnam ku, Seoul 135 710, Korea
    Oncogene 21:3139-48. 2002
    ..Tumor cells with mitochondrial mutations or dysfunction might have the ability to evade tumor surveillance imposed by TRAIL in vivo...
  13. ncbi request reprint Caspase-mediated p65 cleavage promotes TRAIL-induced apoptosis
    Hun Sik Kim
    Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Kangnam Ku, Seoul, Korea
    Cancer Res 65:6111-9. 2005
    ....
  14. ncbi request reprint Heterogeneity of early-onset and ketosis-resistant diabetes in Korean subjects--is it possible to determine cut-off age of early-onset type 2 diabetes?
    Byung Wan Lee
    Division of Endocrinology and Metabolism, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Ilwon Dong, Kangnam Ku, Seoul 135 710, Republic of Korea
    Diabetes Res Clin Pract 70:38-45. 2005
    ..To investigate the heterogeneity of early-onset and ketosis-resistant diabetes and to define a not-arbitrary cut-off age for early-onset diabetes based on its clinical and metabolic characteristics, and diabetes complications...
  15. pmc PPAR-γ activation increases insulin secretion through the up-regulation of the free fatty acid receptor GPR40 in pancreatic β-cells
    Hyo Sup Kim
    Division of Endocrinology and Metabolism, Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine, Seoul, Korea
    PLoS ONE 8:e50128. 2013
    ..We investigated whether PPAR-γ activation stimulates insulin secretion through the up-regulation of GPR40 in pancreatic β-cells...
  16. ncbi request reprint Role of calcium in pancreatic islet cell death by IFN-gamma/TNF-alpha
    Inik Chang
    Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
    J Immunol 172:7008-14. 2004
    ....
  17. ncbi request reprint USF inhibits cell proliferation through delay in G2/M phase in FRTL-5 cells
    Hye Seung Jung
    Division of Endocrinology and Metabolism, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Korea
    Endocr J 54:275-85. 2007
    ..However, they retained the ability to produce cAMP after TSH stimulation. Their inhibitory effect on cell proliferation might be caused partly by the delay in G2/M phase...
  18. doi request reprint Role of JNK activation in pancreatic beta-cell death by streptozotocin
    Hwanju Cheon
    Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea
    Mol Cell Endocrinol 321:131-7. 2010
    ..These results suggest that JNK is activated by STZ downstream of PARP-1 through inactivation of phosphatases such as MKP, which plays important roles in STZ-induced beta-cell death...
  19. pmc NF-kappa B prevents beta cell death and autoimmune diabetes in NOD mice
    Sunshin Kim
    Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Irwon dong, Kangnam Ku, Seoul, Korea
    Proc Natl Acad Sci U S A 104:1913-8. 2007
    ..This differs from the proapoptotic function of NF-kappaB in IL-1beta-stimulated beta cells...
  20. ncbi request reprint TGF-beta inhibits Fas-mediated apoptosis of a follicular dendritic cell line by down-regulating the expression of Fas and caspase-8: counteracting role of TGF-beta on TNF sensitization of Fas-mediated apoptosis
    Sun Mi Park
    Department of Biology and Protein Network Research Center, Yonsei University, Seoul, Korea
    J Immunol 174:6169-75. 2005
    ..Our study documents a novel function of TGF-beta in the maintenance of FDC networks...
  21. ncbi request reprint The stimulatory effect of IL-1beta on the insulin secretion of rat pancreatic islet is not related with iNOS pathway
    In Kyung Jeong
    Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
    Exp Mol Med 34:12-7. 2002
    ..These results suggested that the stimulatory effect of IL-1beta on the insulin secretion of rat islets is independent of iNOS-related NO production of IL-1beta and the enzyme activity of nitric oxide synthase...
  22. pmc A case of congenital adrenal hyperplasia mimicking Cushing's syndrome
    Hye Jeong Kim
    Division of Endocrinology and Metabolism, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
    J Korean Med Sci 27:1439-43. 2012
    ..CAH was confirmed by a remarkably increased level of serum 17-hydroxyprogesterone level. Gene mutation analysis revealed a compound heterozygote mutation of CYP21A2 (I173N and R357W)...
  23. pmc Pathologic changes and glucose homeostasis according to expression of human islet amyloid polypeptide in type 2 diabetic patients
    Ji Young Park
    Division of Endocrinology and Metabolism, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea
    J Histochem Cytochem 58:731-40. 2010
    ..IAPP, including oligomer, may be an important determinant in the fate of islet beta-cells. This manuscript contains online supplemental material at http://www.jhc.org. Please visit this article online to view these materials...
  24. pmc Lysophosphatidylcholine as an effector of fatty acid-induced insulin resistance
    Myoung Sook Han
    Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 135 710, Korea
    J Lipid Res 52:1234-46. 2011
    ..LPC content was increased in the liver and muscle of db/db mice, which was suppressed by BEL. These findings implicate LPC as an important lipid intermediate that links saturated fatty acids to insulin resistance...
  25. doi request reprint Activin A, exendin-4, and glucose stimulate differentiation of human pancreatic ductal cells
    Hyo Sup Kim
    Division of Endocrinology and Metabolism, Department of Medicine, Sungkyunkwan University School of Medicine, Samsung Biomedical Research Institute, Samsung Medical Center, 50 Ilwon Dong, Kangnam Ku, Seoul 135 710, Republic of Korea Korea
    J Endocrinol 217:241-52. 2013
    ....
  26. doi request reprint Autophagy deficiency leads to protection from obesity and insulin resistance by inducing Fgf21 as a mitokine
    Kook Hwan Kim
    Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
    Nat Med 19:83-92. 2013
    ....
  27. doi request reprint Improved outcome of islet transplantation in partially pancreatectomized diabetic mice by inhibition of dipeptidyl peptidase-4 with sitagliptin
    Young Seok Kim
    Department of Molecular Medicine, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea
    Pancreas 40:855-60. 2011
    ..This study was designed to evaluate the effects of sitagliptin (sita), a DPP-4 inhibitor, on the outcome of islet transplantation (ITx) in diabetic mice after partial pancreatectomy (Px)...
  28. ncbi request reprint Essential role for signal transducer and activator of transcription-1 in pancreatic beta-cell death and autoimmune type 1 diabetes of nonobese diabetic mice
    Sunshin Kim
    Department of Medicine, Samsung Medical Center, 50 Irwon dong Kangnam ku, Seoul 135 710, Korea
    Diabetes 56:2561-8. 2007
    ..However, in vivo evidence supporting the role for STAT1 in natural type 1 diabetes has not been reported. We studied whether STAT1 plays an important role in the development of natural type 1 diabetes...
  29. pmc Korean type 2 diabetes patients have multiple adenomatous polyps compared to non-diabetic controls
    Sunghwan Suh
    Division of Endocrinology and Metabolism, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
    J Korean Med Sci 26:1196-200. 2011
    ..Male patients older than 65 yr with T2DM and BMI greater than 25 have increased risk for multiple adenomatous polyps and should be screened with colonoscopy to prevent colorectal cancer...
  30. doi request reprint Metformin enhances glucagon-like peptide 1 via cooperation between insulin and Wnt signaling
    Mi Hyun Kim
    Division of Endocrinology and Metabolism, Samsung Biomedical Research Institute, 50 Ilwon Dong, Gangnam Gu, Seoul 135 710, Republic of Korea Division of Endocrinology and Metabolism, Department of Medicine Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Ilwon Dong, Gangnam Gu, Seoul 135 710, Republic of Korea
    J Endocrinol 220:117-28. 2014
    ..Our findings indicate that the cooperation between Wnt and its upstream insulin signaling pathways might be a novel and important mechanism underlying the effects of metformin on GLP1 production. ..
  31. doi request reprint Non-HDL-cholesterol/HDL-cholesterol is a better predictor of metabolic syndrome and insulin resistance than apolipoprotein B/apolipoprotein A1
    Se Won Kim
    Division of Endocrinology and Metabolism, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea
    Int J Cardiol 168:2678-83. 2013
    ..However, it is unclear whether the ratio of non-HDL-C to HDL-C is an equal or a better predictor than the apoB/apoA1 ratio for the identification of MetS and IR...
  32. ncbi request reprint Significance of beta2-adrenergic receptor gene polymorphism in obesity and type 2 diabetes mellitus in Korean subjects
    Sung Hoon Kim
    Division of Endocrinology and Metabolism, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
    Metabolism 51:833-7. 2002
    ..The frequency of the Glu27 homozygote was 1.1%. These findings suggest that genetic variability in the ADRB2 gene may not be a major determinant for the development of obesity and diabetes in Koreans...
  33. doi request reprint Trophic molecules derived from human mesenchymal stem cells enhance survival, function, and angiogenesis of isolated islets after transplantation
    Ki Soo Park
    Department of Molecular Medicine, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea
    Transplantation 89:509-17. 2010
    ..We hypothesized that MSC-secreted molecules would induce a trophic effect in pancreatic islet culture conditions...
  34. ncbi request reprint Cellular aging of mitochondrial DNA-depleted cells
    Sun Young Park
    Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Irwon dong Kangnam ku, Seoul 135 710, Republic of Korea
    Biochem Biophys Res Commun 325:1399-405. 2004
    ..Features simulating aged cells were also observed in MDA-MB-435 rho(0) cells. These results support the mitochondrial theory of aging, and suggest that rho(0) cells could serve as an in vitro model for aged cells...
  35. ncbi request reprint Metastasis-associated protein 1 enhances angiogenesis by stabilization of HIF-1alpha
    Hyo Eun Moon
    Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 135 710, Korea
    Oncol Rep 16:929-35. 2006
    ..These results indicate that MTA1 enhances angiogenesis by stabilization of the HIF-1alpha protein, which is closely related to the increased metastatic potential of cancer cells with high MTA1 expression...
  36. doi request reprint Glucagon/insulin ratio in preoperative screening before pancreatic surgery: correlation with hemoglobin A1C in subjects with and without pancreatic cancer
    Sang Man Jin
    Division of Endocrinology and Metabolism, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Ilwon Dong, Gangnam Gu, Seoul, 135 710, Republic of Korea
    Endocrine 47:493-9. 2014
    ....
  37. doi request reprint Metformin-induced inhibition of the mitochondrial respiratory chain increases FGF21 expression via ATF4 activation
    Kook Hwan Kim
    Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Irwon dong Gangnam gu, Seoul 135 710, South Korea Samsung Advanced Institute for Health Sciences and Technology, Sungkyunkwan University School of Medicine, 50 Irwon dong Gangnam gu, Seoul 135 710, South Korea
    Biochem Biophys Res Commun 440:76-81. 2013
    ..Therefore, FGF21 induction by metformin might explain a portion of the beneficial metabolic effects of metformin...
  38. pmc A patient with primary squamous cell carcinoma of the thyroid intermingled with follicular thyroid carcinoma that remains alive more than 8 years after diagnosis
    Tae Sik Jung
    Division of Endocrinology and Metabolism, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
    Korean J Intern Med 21:73-8. 2006
    ..Recent evaluation has revealed a new lesion in the lung; this was diagnosed as metastatic follicular carcinoma originating from the thyroid. High dose radioactive iodine therapy was administered, and he remains alive in stable condition...
  39. ncbi request reprint Continued suppression of serum TSH level may be attributed to TSH receptor antibody activity as well as the severity of thyrotoxicosis and the time to recovery of thyroid hormone in treated euthyroid Graves' patients
    Yun Jae Chung
    Division of Endocrinology and Metabolism, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
    Thyroid 16:1251-7. 2006
    ....
  40. ncbi request reprint Toll-like receptor 2 senses beta-cell death and contributes to the initiation of autoimmune diabetes
    Hun Sik Kim
    Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 135 710, Korea
    Immunity 27:321-33. 2007
    ..These findings suggest that beta-cell death and its sensing via TLR2 may be an initial event for the stimulation of antigen-presenting cells and development of autoimmune diabetes...
  41. ncbi request reprint Soluble Fas ligand-susceptible "memory" cells in mice but not in human: potential role of soluble Fas ligand in deletion of auto-reactive cells
    Sunshin Kim
    Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea
    Autoimmunity 35:15-20. 2002
    ....
  42. doi request reprint Role of hypothalamic proopiomelanocortin neuron autophagy in the control of appetite and leptin response
    WenYing Quan
    Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 135 710, Korea
    Endocrinology 153:1817-26. 2012
    ..Our findings indicate a critical role for autophagy of POMC neurons in the control of energy homeostasis and leptin signaling...
  43. doi request reprint A novel dipeptidyl peptidase IV inhibitor DA-1229 ameliorates streptozotocin-induced diabetes by increasing β-cell replication and neogenesis
    Jae Min Cho
    Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Irwon dong, Gangnam Gu, Seoul 135 710, Republic of Korea
    Diabetes Res Clin Pract 91:72-9. 2011
    ..These results suggest a therapeutic potential of DA-1229 in diabetes, particularly that associated with decreased β-cell mass...
  44. doi request reprint Systemic autophagy insufficiency compromises adaptation to metabolic stress and facilitates progression from obesity to diabetes
    Yu Mi Lim
    Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 135 710, Korea
    Nat Commun 5:4934. 2014
    ..These results suggest that systemic autophagy insufficiency could be a factor in the progression from obesity to diabetes, and autophagy modulators have therapeutic potential against diabetes associated with obesity and inflammation. ..
  45. doi request reprint Role of hypothalamic autophagy in the control of whole body energy balance
    Min Seon Kim
    Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, 138 736, Korea
    Rev Endocr Metab Disord 14:377-86. 2013
    ..Thus, mice with autophagy deficiency in the hypothalamus have shown diverse phenotypes (lean vs. obese) depending on the site of autophagy deficiency or the method of autophagy abrogation. ..
  46. doi request reprint An increase in the Akkermansia spp. population induced by metformin treatment improves glucose homeostasis in diet-induced obese mice
    Na Ri Shin
    Department of Life and Nanopharmaceutical Sciences and Department of Biology, Kyung Hee University, Seoul, Korea
    Gut 63:727-35. 2014
    ..Metformin is one of the most widely prescribed type 2 diabetes (T2D) therapeutic agents...
  47. pmc Acute exercise induces FGF21 expression in mice and in healthy humans
    Kook Hwan Kim
    Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Irwon dong Gangnam gu, Seoul, Korea
    PLoS ONE 8:e63517. 2013
    ..These results suggest that FGF21 may also be associated with exercise-induced lipolysis in addition to increased catecholamines and reduced insulin...
  48. doi request reprint Rosiglitazone stimulates the release and synthesis of insulin by enhancing GLUT-2, glucokinase and BETA2/NeuroD expression
    Hyo Sup Kim
    Division of Endocrinology and Metabolism, Samsung Biomedical Research Institute SBRI, Seoul, Republic of Korea
    Biochem Biophys Res Commun 367:623-9. 2008
    ..These results suggest that RGZ could stimulate the release and synthesis of insulin through the upregulation of GLUT-2, GCK, and BETA2/NeuroD gene expression...
  49. ncbi request reprint N-terminal pro-brain natriuretic peptide (NT-proBNP) in Type 2 diabetes with left ventricular dysfunction
    Ji Youn Kim
    Division of Endocrinology and Metabolism, Department of Medicine, Seoul, Korea
    Diabetes Res Clin Pract 77:S238-42. 2007
    ..001). NT-proBNP levels significantly differed among three groups according to urinary albumin excretion (P=0.031). These results suggest that NT-proBNP could be used to identify any impairment of left ventricular function in diabetes...
  50. ncbi request reprint Effects of activin A on pancreatic ductal cells in streptozotocin-induced diabetic rats
    Mi Kyung Park
    Division of Endocrinology and Metabolism, Samsung Biomedical Research Institute, Seoul, Korea
    Transplantation 83:925-30. 2007
    ..In this study, we examined whether activin A can promote the expansion and/or differentiation of ductal cells into insulin-producing cells...
  51. pmc Differentiation and transplantation of functional pancreatic beta cells generated from induced pluripotent stem cells derived from a type 1 diabetes mouse model
    Kilsoo Jeon
    1 Department of Animal Biotechnology BK21, Animal Resources Research Center, and SMART IABS, Konkuk University, Seoul, Republic of Korea
    Stem Cells Dev 21:2642-55. 2012
    ....
  52. doi request reprint Inhibition of autoimmune diabetes by TLR2 tolerance
    Do Hoon Kim
    Department of Medicine, Samsung Medical Center, Seoul 135 710, Korea
    J Immunol 187:5211-20. 2011
    ..TLR2 modulation could be used as a novel therapeutic modality against autoimmune diabetes...
  53. pmc Autophagy deficiency in myeloid cells increases susceptibility to obesity-induced diabetes and experimental colitis
    Hae Youn Lee
    a Departments of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
    Autophagy 12:1390-403. 2016
    ....
  54. doi request reprint Role of autophagy in the progression from obesity to diabetes and in the control of energy balance
    WenYing Quan
    Department of Medicine and Samsung Advanced Institute for Health Sciences and Technology, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Irwon dong, Gangnam Gu, Seoul, 135 710, South Korea
    Arch Pharm Res 36:223-9. 2013
    ..Thus, autophagy is important to body and nutrient metabolism in many ways, and its dysregulation could contribute to the pathogenesis of metabolic disorders and diabetes...
  55. pmc Essential role of STAT1 in caspase-independent cell death of activated macrophages through the p38 mitogen-activated protein kinase/STAT1/reactive oxygen species pathway
    Hun Sik Kim
    Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Irwon dong, Kangnam Ku, Seoul 135 710, South Korea
    Mol Cell Biol 25:6821-33. 2005
    ..Furthermore, our study may provide significant insights in regards to the unanticipated critical role of STAT1 in the caspase-independent death pathway...
  56. ncbi request reprint A novel compound heterozygous mutation in the CYP17 (P450 17alpha-hydroxylase) gene leading to 17alpha-hydroxylase/17,20-lyase deficiency
    Jong Ryeal Hahm
    Division of Endocrinology and Metabolism, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
    Metabolism 52:488-92. 2003
    ..Here we conclude that these novel compound heterozygous mutations might account for the patient's clinical manifestations of 17alpha-hydroxylase/17,20-lyase deficiency...
  57. ncbi request reprint Prevalence, clinical and ultrasonographic characteristics of thyroid incidentalomas
    Hahn Wook Kang
    Division of Endocrinology and Metabolism, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
    Thyroid 14:29-33. 2004
    ..There were no significant differences in clinical and laboratory parameters between benign and malignant thyroid nodules <1.5 cm; however, US findings can be used in the decision of optimal management strategies...
  58. pmc Autosomal dominant hypocalcemia caused by an activating mutation of the calcium-sensing receptor gene: the first case report in Korea
    Mi Yeon Kim
    Division of Endocrinology and Metabolism, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
    J Korean Med Sci 25:317-20. 2010
    ..Here we describe members of a Korean family with a heterozygous Pro221Leu mutation causing ADH. This case is the first report in Korea...
  59. pmc Regular exercise is associated with a reduction in the risk of NAFLD and decreased liver enzymes in individuals with NAFLD independent of obesity in Korean adults
    Ji Cheol Bae
    Division of Endocrinology and Metabolism, Department of Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea
    PLoS ONE 7:e46819. 2012
    ..We evaluated the association of regular physical exercise with the presence of non-alcoholic fatty liver disease (NAFLD) and liver enzymes in relation to obesity and insulin resistance...
  60. ncbi request reprint Lysophosphatidylcholine as a death effector in the lipoapoptosis of hepatocytes
    Myoung Sook Han
    Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 135 710, Korea
    J Lipid Res 49:84-97. 2008
    ..These results demonstrate that LPC is a death effector in the lipoapoptosis of hepatocytes and suggest potential therapeutic values of PLA(2) inhibitors or GPCR/Galpha(i) inhibitors in NASH...
  61. doi request reprint Role of autophagy in diabetes and mitochondria
    Hye Seung Jung
    Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea
    Ann N Y Acad Sci 1201:79-83. 2010
    ..Furthermore, since aging is associated with impaired glucose tolerance, decline of autophagic activity may be involved in age-associated reduction of glucose tolerance...
  62. ncbi request reprint Three-day continuous glucose monitoring for rapid assessment of hypoglycemic events and glycemic variability in type 1 diabetic patients
    Soo Kyoung Kim
    Division of Endocrinology and Metabolism, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
    Endocr J 58:535-41. 2011
    ..The short-term CGMS appears to be clinically useful for rapidly assessing the risk of hypoglycemic events and glycemic variability...
  63. doi request reprint Diagnostic accuracy of plasma free metanephrines in a seated position compared with 24-hour urinary metanephrines in the investigation of pheochromocytoma
    Hye Jeong Kim
    Division of Endocrinology and Metabolism, Department of Internal Medicine, Soonchunhyang University Hospital, Soonchunhyang University College of Medicine, Seoul, Korea
    Endocr J 62:243-50. 2015
    ..We suggest that free metanephrines in plasma drawn from seated position can also be used as an initial screening test to ensure that pheochromocytomas are not missed in Asian patients. ..
  64. doi request reprint Co-culture with mature islet cells augments the differentiation of insulin-producing cells from pluripotent stem cells
    Bea Jun Oh
    Division of Endocrinology and Metabolism, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Irwon dong, Gangnam Gu, Seoul, 135 710, Republic of Korea
    Stem Cell Rev 11:62-74. 2015
    ..Immunohistochemistry revealed that insulin+/C-peptide + cells existed in the grafted tissues. These results suggest that mature islet cells can increase the differentiation efficiency of PE cells into mature IPCs via paracrine effects. ..
  65. ncbi request reprint Immunotherapeutic treatment of autoimmune diabetes
    Jae Hyeon Kim
    Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Kyunggi do 410 773, Korea
    Crit Rev Immunol 33:245-81. 2013
    ....
  66. doi request reprint Clinical factors associated with absolute and relative measures of glycemic variability determined by continuous glucose monitoring: an analysis of 480 subjects
    Sang Man Jin
    Division of Endocrinology and Metabolism, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Ilwon Dong, Gangnam Gu, Seoul 135 710, Republic of Korea
    Diabetes Res Clin Pract 104:266-72. 2014
    ..Factors associated with absolute and relative measures of glycemic variability have not been determined by continuous glucose monitoring (CGM) and concurrent measurement of fasting C-peptide levels...
  67. ncbi request reprint RET proto-oncogene mutations are restricted to codon 634 and 618 in Korean families with multiple endocrine neoplasia 2A
    Yun Jae Chung
    Division of Endocrinology and Metabolism, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
    Thyroid 14:813-8. 2004
    ..RET proto-oncogene mutations were restricted to codon 634 and 618 in Korean families with MEN 2A...
  68. ncbi request reprint Bilateral pheochromocytoma associated with paraganglioma and papillary thyroid carcinoma: report of an unusual case
    Jeong Hoon Yang
    Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Korea
    Endocr J 54:227-31. 2007
    ..This is the first report of a combination of bilateral pheochromocytoma, abdominal paraganglioma, papillary thyroid carcinoma and either parathyroid adenoma or hyperplasia without hyperparathyroidism...
  69. doi request reprint Role of TLR2 in the pathogenesis of autoimmune diabetes and its therapeutic implication
    Myung Shik Lee
    Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
    Diabetes Metab Res Rev 27:797-801. 2011
    ..These findings present evidence suggesting that apoptosis of pancreatic β-cells could be one of the initial events in T1D and provide a novel strategy for therapeutic or preventive intervention in T1D...
  70. doi request reprint Loss of autophagy diminishes pancreatic beta cell mass and function with resultant hyperglycemia
    Hye Seung Jung
    Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Irwon dong Kangnam ku, Seoul 135 710, Korea
    Cell Metab 8:318-24. 2008
    ....
  71. doi request reprint Differences in donor CXCR4 expression levels are correlated with functional capacity and therapeutic outcome of angiogenic treatment with endothelial colony forming cells
    Bae Jun Oh
    Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea
    Biochem Biophys Res Commun 398:627-33. 2010
    ....
  72. doi request reprint Macrophages from nonobese diabetic mouse have a selective defect in IFN-γ but not IFN-α/β receptor pathway
    Myung Shik Lee
    Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
    J Clin Immunol 32:753-61. 2012
    ..We aimed to uncover a mechanism underlying this phenomenon...
  73. pmc Education as prescription for patients with type 2 diabetes mellitus: compliance and efficacy in clinical practice
    Mi Yeon Kim
    Division of Endocrinology and Metabolism, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
    Diabetes Metab J 36:452-9. 2012
    ..However, the status of diabetes education programs in real Korean clinical practice has not yet been evaluated in terms of patient compliance with the education prescription...
  74. pmc Comparisons between macroadenomas and microadenomas in Cushing's disease: characteristics of hormone secretion and clinical outcomes
    You Cheol Hwang
    Division of Endocrinology and Metabolism, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
    J Korean Med Sci 24:46-51. 2009
    ..73.3% [11/15] for microadenoma patients, p=0.53). Thus, tumor size is not a major determinant of hormone secretion or clinical outcomes in patients with Cushing's disease...
  75. ncbi request reprint Recent progress in research on beta-cell apoptosis by cytokines
    Kyoung Ah Kim
    Department of Medicine, Dongguk University International Hospital, Dongguk University School of Medicine, Goyang, Korea
    Front Biosci (Landmark Ed) 14:657-64. 2009
    ....
  76. pmc Imatinib mesylate reduces endoplasmic reticulum stress and induces remission of diabetes in db/db mice
    Myoung Sook Han
    Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
    Diabetes 58:329-36. 2009
    ..We studied the effect of imatinib on diabetes in db/db mice and investigated possible mechanism's underlying improved glycemic control by imatinib...
  77. pmc Overexpression of USF increases TGF-beta1 protein levels, but G1 phase arrest was not induced in FRTL-5 cells
    Keun Sook Kim
    Department of Medicine, Samsung Medical Center, Jungkyunkwan University School of Medicine, Seoul, Korea
    J Korean Med Sci 23:870-6. 2008
    ..Overexpression of USF in FRTL-5 cells increased the expression of TGF-beta10 through specific binding to TGF-beta1 promoter. However, the USF-induced expression of TGF-beta1 did not cause G1 arrest...
  78. pmc Role of autophagy in diabetes and endoplasmic reticulum stress of pancreatic β-cells
    WenYing Quan
    Department of Medicine and Samsung Advanced Institute for Health Sciences and Technology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 153 710, Korea
    Exp Mol Med 44:81-8. 2012
    ..Thus, autophagy deficiency in β-cells could be a precipitating factor in the progression from obesity to diabetes due to inappropriate response to obesity-induced ER stress...
  79. doi request reprint Phosphodiesterase inhibitors control A172 human glioblastoma cell death through cAMP-mediated activation of protein kinase A and Epac1/Rap1 pathways
    Eun Yi Moon
    Department of Bioscience and Biotechnology, Sejong University, Seoul, Republic of Korea
    Life Sci 90:373-80. 2012
    ....
  80. ncbi request reprint STAT1 as a key modulator of cell death
    Hun Sik Kim
    Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea
    Cell Signal 19:454-65. 2007
    ....
  81. doi request reprint Metabolic syndrome as a predictor of cardiovascular diseases and type 2 diabetes in Koreans
    You Cheol Hwang
    Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea
    Int J Cardiol 134:313-21. 2009
    ..The purpose of this study was to investigate whether the presence of the NCEP-ATP III defined metabolic syndrome (MS) is associated with the future development of cardiovascular disease (CVD) and diabetes in Koreans...
  82. ncbi request reprint Role of innate immunity in triggering and tuning of autoimmune diabetes
    Hun Sik Kim
    Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
    Curr Mol Med 9:30-44. 2009
    ....
  83. doi request reprint Lipid raft proteome reveals that oxidative phosphorylation system is associated with the plasma membrane
    Bong Woo Kim
    College of Life Sciences and Biotechnology, Korea University, 1, 5 Ka, Anam Dong, Sungbuk Ku, Seoul, Korea
    Expert Rev Proteomics 7:849-66. 2010
    ..We discuss the findings of OXPHOS complexes in lipid rafts, the role of the surface ATP synthase complex as a receptor for various ligands and extracellular superoxide generation by plasma membrane oxidative phosphorylation complexes...
  84. ncbi request reprint Effective glycemic control achieved by transplanting non-viral cationic liposome-mediated VEGF-transfected islets in streptozotocin-induced diabetic mice
    Hee Young Chae
    Samsung Biomedical Research Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 100 380, Korea
    Exp Mol Med 37:513-23. 2005
    ..However, hyperglycemia was completely abrogated in the IT-pJDK-VEGF transduced group (8/8), and viable islets and increased VEGF-transfected grafts vascularization were observed in renal capsules...
  85. ncbi request reprint Metastasis-associated protein 1 inhibits p53-induced apoptosis
    Hyo Eun Moon
    Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Irwon dong, Kangnam Ku, Seoul 135 710, Korea
    Oncol Rep 18:1311-4. 2007
    ..These results indicate that MTA1 inhibits p53-induced apoptosis by deacetylation of p53, which might be related to the increased metastatic potential of cancer cells with high MTA1 expression...
  86. ncbi request reprint Macroautophagy in homeostasis of pancreatic beta-cell
    Hye Seung Jung
    Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Kangnam Ku, Seoul, Korea
    Autophagy 5:241-3. 2009
    ..Here we discuss the significance of autophagy in pancreatic beta-cells with its potential relevance to the development of diabetes...
  87. ncbi request reprint RET oligonucleotide microarray for the detection of RET mutations in multiple endocrine neoplasia type 2 syndromes
    Il Jin Kim
    Familial Cancer Clinic, National Cancer Center, 809 Madu dong, Ilsan gu, Goyang, Gyeonggi 411 764, Korea
    Clin Cancer Res 8:457-63. 2002
    ..Taken together, the RET oligonucleotide microarray can function as a fast and reliable genetic diagnostic device, which simplifies the process of detecting RET mutations...
  88. pmc Platelet-activating factor-mediated NF-kappaB dependency of a late anaphylactic reaction
    Il Whan Choi
    Department of Immunology, University National Medical School, Chonju, Chonbuk, 561 182, South Korea
    J Exp Med 198:145-51. 2003
    ..Together, this work reveals the first mechanistic basis for biphasic anaphylactic reactions and provides possible therapeutic strategies for human anaphylaxis...
  89. pmc Saturated fatty acids inhibit induction of insulin gene transcription by JNK-mediated phosphorylation of insulin-receptor substrates
    Giovanni Solinas
    Laboratory of Gene Regulation and Signal Transduction, School of Medicine, University of California at San Diego, 9500 Gilman Drive, MC 0723, La Jolla, CA 92093 0723, USA
    Proc Natl Acad Sci U S A 103:16454-9. 2006
    ..This mechanism may account for the induction of central insulin resistance by free fatty acids...
  90. pmc Fasting plasma glucose cutoff value for the prediction of future diabetes development: a study of middle-aged Koreans in a health promotion center
    Dong Jun Kim
    Department of Internal Medicine, Ilsan Paik Hospital, Inje University College of Medicine, Goyang, Korea
    J Korean Med Sci 20:562-5. 2005
    ..Our data shows that the risk of future diabetes development started to increase below an FPG of 6.1 mM/L and suggests the importance of efforts to modify diabetes development risk factors at lower impaired fasting glucose levels...
  91. ncbi request reprint Role of antiproliferative B cell translocation gene-1 as an apoptotic sensitizer in activation-induced cell death of brain microglia
    Heasuk Lee
    Department of Anatomy and Neurobiology and Research Institute of Natural Science, Gyeongsang National University College of Medicine, Institute of Health Sciences, Jinju, Korea
    J Immunol 171:5802-11. 2003
    ..Our results point out an important link between the proliferative state of microglia and their sensitivity to apoptogenic agents...
  92. ncbi request reprint Thyrotropin-mediated repression of class II trans-activator expression in thyroid cells: involvement of STAT3 and suppressor of cytokine signaling
    Ho Kim
    Laboratory of Endocrine Cell Biology, Department of Internal Medicine, Chungnam National University School of Medicine, Daejon, Korea
    J Immunol 171:616-27. 2003
    ..This report suggests that TSH is also engaged in immunomodulation through signal cross-talk with the cytokines in thyroid cells...
  93. ncbi request reprint Sequential induction of heme oxygenase-1 and manganese superoxide dismutase protects cultured astrocytes against nitric oxide
    Eunyung Son
    Department of Pharmacology, Kyungpook National University School of Medicine, 101 Dong In, Joong Gu, Daegu, 700 422 Korea
    Biochem Pharmacol 70:590-7. 2005
    ....
  94. ncbi request reprint Synergy of glucose and growth hormone signalling in islet cells through ICA512 and STAT5
    Hassan Mziaut
    Experimental Diabetology, School of Medicine, Dresden University of Technology, Dresden 01307, Germany
    Nat Cell Biol 8:435-45. 2006
    ....