Sung Key Jang

Summary

Affiliation: Pohang University of Science and Technology
Country: Korea

Publications

  1. pmc A cellular RNA-binding protein enhances internal ribosomal entry site-dependent translation through an interaction downstream of the hepatitis C virus polyprotein initiation codon
    Jong Heon Kim
    NRL, PBC, Division of Molecular and Life Sciences, Pohang University of Science and Technology, Hyoja Dong San 31, Pohang, Kyungbuk 790 784, South Korea
    Mol Cell Biol 24:7878-90. 2004
  2. ncbi request reprint Internal initiation: IRES elements of picornaviruses and hepatitis c virus
    Sung Key Jang
    NRL, PBC, Department of Life Science, Division of Molecular and Life Sciences, Pohang University of Science and Technology, Pohang 790 784, Republic of Korea
    Virus Res 119:2-15. 2006
  3. pmc Polypyrimidine tract-binding protein enhances the internal ribosomal entry site-dependent translation of p27Kip1 mRNA and modulates transition from G1 to S phase
    Sungchan Cho
    PBC, Division of Molecular and Life Science, Pohang University of Science and Technology, San 31, Hyoja Dong, Pohang, Kyungbuk 790 784, South Korea
    Mol Cell Biol 25:1283-97. 2005
  4. pmc BiP internal ribosomal entry site activity is controlled by heat-induced interaction of NSAP1
    Sungchan Cho
    Department of Life Science, Pohang University of Science and Technology, San 31, Hyoja Dong, Pohang, Kyungbuk 790 784, Republic of Korea
    Mol Cell Biol 27:368-83. 2007
  5. doi request reprint A molecular chaperone glucose-regulated protein 94 blocks apoptosis induced by virus infection
    Song Hee Lee
    PBC, Department of Life Science, Pohang University of Science and Technology, Hyoja Dong, Pohang, Kyungbuk, Korea
    Hepatology 47:854-66. 2008
  6. pmc Rhythmic control of AANAT translation by hnRNP Q in circadian melatonin production
    Tae Don Kim
    Department of Life Science, Division of Molecular and Life Sciences, Systems Bio Dynamics NCRC, Pohang University of Science and Technology, Pohang, Kyung Buk 790 784, Republic of Korea
    Genes Dev 21:797-810. 2007
  7. ncbi request reprint Polypyrimidine tract-binding proteins are cleaved by caspase-3 during apoptosis
    Sung Hoon Back
    National Research Laboratory, Department of Life Science, Division of Molecular and Life Sciences, Pohang University of Science and Technology, San31, Hyoja Dong, Pohang, Kyungbuk 790 784, Korea
    J Biol Chem 277:27200-9. 2002
  8. pmc RNA-binding protein hnRNP D modulates internal ribosome entry site-dependent translation of hepatitis C virus RNA
    Ki Young Paek
    Postech Biotech Center, Department of Life Science, Pohang University of Science and Technology, San 31, Hyoja Dong, Pohang, Kyungbuk 790 784, Republic of Korea
    J Virol 82:12082-93. 2008
  9. pmc Proline-rich transcript in brain protein induces stress granule formation
    Jung Eun Kim
    PBC, Department of Life Science, Pohang University of Science and Technology, San31, Hyoja Dong, Pohang 790 784, Republic of Korea
    Mol Cell Biol 28:803-13. 2008
  10. pmc AUF1 contributes to Cryptochrome1 mRNA degradation and rhythmic translation
    Kyung Ha Lee
    Department of Life Sciences, Pohang University of Science and Technology, San 31 Hyoja Dong, Pohang, Gyeongbuk 790 784, Republic of Korea, School of Interdisciplinary Bioscience and Bioengineering, Pohang University of Science and Technology, San 31 Hyoja Dong, Pohang, Gyeongbuk 790 784, Republic of Korea and Division of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology, San 31 Hyoja Dong, Pohang, Gyeongbuk 790 784, Republic of Korea
    Nucleic Acids Res 42:3590-606. 2014

Collaborators

Detail Information

Publications55

  1. pmc A cellular RNA-binding protein enhances internal ribosomal entry site-dependent translation through an interaction downstream of the hepatitis C virus polyprotein initiation codon
    Jong Heon Kim
    NRL, PBC, Division of Molecular and Life Sciences, Pohang University of Science and Technology, Hyoja Dong San 31, Pohang, Kyungbuk 790 784, South Korea
    Mol Cell Biol 24:7878-90. 2004
    ..These results suggest the existence of a novel mechanism of translational enhancement that acts through the interaction of an RNA-binding protein with a protein coding sequence...
  2. ncbi request reprint Internal initiation: IRES elements of picornaviruses and hepatitis c virus
    Sung Key Jang
    NRL, PBC, Department of Life Science, Division of Molecular and Life Sciences, Pohang University of Science and Technology, Pohang 790 784, Republic of Korea
    Virus Res 119:2-15. 2006
    ....
  3. pmc Polypyrimidine tract-binding protein enhances the internal ribosomal entry site-dependent translation of p27Kip1 mRNA and modulates transition from G1 to S phase
    Sungchan Cho
    PBC, Division of Molecular and Life Science, Pohang University of Science and Technology, San 31, Hyoja Dong, Pohang, Kyungbuk 790 784, South Korea
    Mol Cell Biol 25:1283-97. 2005
    ..Together, these data suggest that PTB modulates cell cycle and differentiation, at least in part, by enhancing the IRES activity of p27(Kip1) mRNA...
  4. pmc BiP internal ribosomal entry site activity is controlled by heat-induced interaction of NSAP1
    Sungchan Cho
    Department of Life Science, Pohang University of Science and Technology, San 31, Hyoja Dong, Pohang, Kyungbuk 790 784, Republic of Korea
    Mol Cell Biol 27:368-83. 2007
    ..Together, these data indicate that NSAP1 modulates IRES-dependent translation of BiP mRNA through an RNA-protein interaction under heat stress conditions...
  5. doi request reprint A molecular chaperone glucose-regulated protein 94 blocks apoptosis induced by virus infection
    Song Hee Lee
    PBC, Department of Life Science, Pohang University of Science and Technology, Hyoja Dong, Pohang, Kyungbuk, Korea
    Hepatology 47:854-66. 2008
    ..Moreover, small interfering RNA (siRNA) knock-down of GRP94 nullified the anti-apoptotic activity of HCV E2...
  6. pmc Rhythmic control of AANAT translation by hnRNP Q in circadian melatonin production
    Tae Don Kim
    Department of Life Science, Division of Molecular and Life Sciences, Systems Bio Dynamics NCRC, Pohang University of Science and Technology, Pohang, Kyung Buk 790 784, Republic of Korea
    Genes Dev 21:797-810. 2007
    ..This translational regulation of AANAT mRNA provides a novel aspect for achieving the circadian rhythmicity of vertebrate melatonin...
  7. ncbi request reprint Polypyrimidine tract-binding proteins are cleaved by caspase-3 during apoptosis
    Sung Hoon Back
    National Research Laboratory, Department of Life Science, Division of Molecular and Life Sciences, Pohang University of Science and Technology, San31, Hyoja Dong, Pohang, Kyungbuk 790 784, Korea
    J Biol Chem 277:27200-9. 2002
    ..This suggests that translation of some IRES-containing mRNAs is regulated by proteolytic cleavage of PTB during apoptosis...
  8. pmc RNA-binding protein hnRNP D modulates internal ribosome entry site-dependent translation of hepatitis C virus RNA
    Ki Young Paek
    Postech Biotech Center, Department of Life Science, Pohang University of Science and Technology, San 31, Hyoja Dong, Pohang, Kyungbuk 790 784, Republic of Korea
    J Virol 82:12082-93. 2008
    ..Moreover, knockdown of hnRNP D with siRNA significantly hampers infection by HCV. A potential role of hnRNP D in HCV proliferation is discussed...
  9. pmc Proline-rich transcript in brain protein induces stress granule formation
    Jung Eun Kim
    PBC, Department of Life Science, Pohang University of Science and Technology, San31, Hyoja Dong, Pohang 790 784, Republic of Korea
    Mol Cell Biol 28:803-13. 2008
    ....
  10. pmc AUF1 contributes to Cryptochrome1 mRNA degradation and rhythmic translation
    Kyung Ha Lee
    Department of Life Sciences, Pohang University of Science and Technology, San 31 Hyoja Dong, Pohang, Gyeongbuk 790 784, Republic of Korea, School of Interdisciplinary Bioscience and Bioengineering, Pohang University of Science and Technology, San 31 Hyoja Dong, Pohang, Gyeongbuk 790 784, Republic of Korea and Division of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology, San 31 Hyoja Dong, Pohang, Gyeongbuk 790 784, Republic of Korea
    Nucleic Acids Res 42:3590-606. 2014
    ....
  11. pmc Heterogeneous nuclear ribonucleoprotein C modulates translation of c-myc mRNA in a cell cycle phase-dependent manner
    Jong Heon Kim
    National Research Laboratory, Department of Life Science, Division of Molecular and Life Sciences, Pohang University of Science and Technology, Pohang, Kyungbuk 790 784, Korea
    Mol Cell Biol 23:708-20. 2003
    ..Taken together, these findings suggest that hnRNP C, via IRES binding, modulates translation of c-myc mRNA in a cell cycle phase-dependent manner...
  12. pmc Discovery of cellular proteins required for the early steps of HCV infection using integrative genomics
    Ji Hoon Park
    Division of Molecular and Life Science, Pohang University of Science and Technology, Pohang, Korea
    PLoS ONE 8:e60333. 2013
    ..The candidate gene list provides a source for identification of new therapeutic targets...
  13. pmc Translation-competent 48S complex formation on HCV IRES requires the RNA-binding protein NSAP1
    Sung Mi Park
    Department of Life Science, Pohang University of Science and Technology, Pohang, Kyungbuk, Republic of Korea
    Nucleic Acids Res 39:7791-802. 2011
    ..NSAP1 seems to accomplish this positioning function by directly binding to both a specific site in the mRNA downstream of the initiation codon and a 40S ribosomal protein (or proteins)...
  14. pmc Cyclic AMP controls mTOR through regulation of the dynamic interaction between Rheb and phosphodiesterase 4D
    Hyun Wook Kim
    Division of Molecular and Life Sciences, Pohang University of Science and Technology, Pohang, Kyungbook 790 784, South Korea
    Mol Cell Biol 30:5406-20. 2010
    ..We also propose a new role for PDE4 as a molecular transducer for cAMP signaling...
  15. doi request reprint Fluorescent peptide indicator displacement assay for monitoring interactions between RNA and RNA binding proteins
    Hyun Seok Jeong
    Department of Chemistry, Pohang University of Science and Technology POSTECH, Pohang, 790 784, Republic of Korea
    Mol Biosyst 9:948-51. 2013
    ..We anticipate that this assay will open up new possibilities for meaningful studies of RNA-RBP interactions...
  16. pmc Rhythmic interaction between Period1 mRNA and hnRNP Q leads to circadian time-dependent translation
    Kyung Ha Lee
    Department of Life Science, Division of Molecular and Life Science, Pohang University of Science and Technology, Pohang, Gyeongbuk, Republic of Korea
    Mol Cell Biol 32:717-28. 2012
    ..Here, we demonstrate 5'-UTR-mediated rhythmic mPer1 translation and provide evidence for posttranscriptional regulation of the circadian rhythmicity of core clock genes...
  17. pmc eIF4GI facilitates the MicroRNA-mediated gene silencing
    Incheol Ryu
    Molecular Virology Laboratory, Postech Biotech Center, Department of Life Science, Pohang University of Science and Technology, Pohang, Korea
    PLoS ONE 8:e55725. 2013
    ..Taken together, these data suggest that eIF4GI participates in the miRNA-mediated post-transcriptional gene silencing by promoting the association of Ago2 with the cap-binding complex...
  18. pmc Translation of polioviral mRNA is inhibited by cleavage of polypyrimidine tract-binding proteins executed by polioviral 3C(pro)
    Sung Hoon Back
    NRL, Department of Life Science, Division of Molecular and Life Sciences, Pohang University of Science and Technology, Pohang, Kyungbuk 790 784, Korea
    J Virol 76:2529-42. 2002
    ..We speculate that the proteolytic cleavage of PTBs may contribute to the molecular switching from translation to replication of polioviral RNA...
  19. pmc eIF2A mediates translation of hepatitis C viral mRNA under stress conditions
    Joon Hyun Kim
    Department of Life Science, Postech Biotech Center, Pohang University of Science and Technology, Pohang, Korea
    EMBO J 30:2454-64. 2011
    ....
  20. pmc Evolutionary history of human disease genes reveals phenotypic connections and comorbidity among genetic diseases
    Solip Park
    School of Interdisciplinary Bioscience and Bioengineering, Biotechnology Research Center, Pohang University of Science and Technology, Pohang, Korea
    Sci Rep 2:757. 2012
    ..We find the evolutionary constraints on disease genes are a new layer of molecular connection in the network-based exploration of human diseases...
  21. doi request reprint The specific infectivity of hepatitis C virus changes through its life cycle
    Sun Ju Keum
    Department of Life Science, Postech Biotech Center, Pohang University of Science and Technology, Pohang, South Korea
    Virology 433:462-70. 2012
    ..The buoyant densities of the infectious virion particles differed with the duration of infection, indicating changes in the compositions of the virion particles...
  22. pmc Anti-inflammatory lipid mediator 15d-PGJ2 inhibits translation through inactivation of eIF4A
    Woo Jae Kim
    Department of Life Science, Pohang University of Science and Technology, Pohang, Republic of Korea
    EMBO J 26:5020-32. 2007
    ..These findings reveal a novel cross-talk between translation and inflammatory response, and offer new approaches to develop anticancer and anti-inflammatory drugs that target translation factors including eIF4A...
  23. pmc Hepatitis C virus infection is blocked by HMGB1 released from virus-infected cells
    Jong Ha Jung
    PBC, Department of Life Science, Pohang University of Science and Technology, San 31, Hyoja Dong, Pohang 790 784, Republic of Korea
    J Virol 85:9359-68. 2011
    ..Further investigations into the roles of HMGB1 in the diseases caused by HCV infection will shed light on and potentially help prevent these serious and prevalent HCV-related diseases...
  24. pmc Identification of cellular proteins enhancing activities of internal ribosomal entry sites by competition with oligodeoxynucleotides
    Kobong Choi
    Department of Life Science, Division of Molecular and Life Sciences, Pohang University of Science and Technology, San 31, Hyoja Dong, Pohang, Kyungbuk 790 784, Korea
    Nucleic Acids Res 32:1308-17. 2004
    ..Using this strategy, we show that poly(rC)-binding proteins 1 and 2 enhance translation through polioviral and rhinoviral IRES elements...
  25. ncbi request reprint PLD2 forms a functional complex with mTOR/raptor to transduce mitogenic signals
    Sang Hoon Ha
    Division of Molecular and Life Sciences, Pohang University of Science and Technology, Pohang, Kyungbook 790 784, Republic of Korea
    Cell Signal 18:2283-91. 2006
    ..Our results demonstrate the importance of localized PA generation for the mitogen-induced activation of mTOR, which is achieved by a specific interaction between PLD2 and mTOR/raptor...
  26. pmc Long-range RNA-RNA interaction between the 5' nontranslated region and the core-coding sequences of hepatitis C virus modulates the IRES-dependent translation
    Yoon Ki Kim
    Department of Life Science, Division of Molecular and Life Sciences, Pohang University of Science and Technology, Pohang, Kyungbuk, Korea
    RNA 9:599-606. 2003
    ..The modulation of protein synthesis by long-range RNA-RNA interaction may play a role in the regulation of viral gene expression...
  27. ncbi request reprint E2 of hepatitis C virus inhibits apoptosis
    Song Hee Lee
    Department of Life Science, Division of Molecular and Life Sciences, Pohang University of Science and Technology, Pohang, Kyungbuk, Korea
    J Immunol 175:8226-35. 2005
    ..Based on these results, we propose that E2 augments persistent HCV infection by blocking host-induced apoptosis of infected cells...
  28. pmc New Mechanism of Hepatic Fibrogenesis: Hepatitis C Virus Infection Induces Transforming Growth Factor β1 Production through Glucose-Regulated Protein 94
    Min Hyeok Jee
    Postech Biotech Center, Department of Life Sciences, Pohang University of Science and Technology, Pohang, Kyungbuk, Republic of Korea
    J Virol 90:3044-55. 2015
    ..Moreover, we showed that HCV E2 protein triggers the production of TGF-β1 by HCV-infected cells through overproduction of glucose-regulated protein 94 (GRP94)...
  29. pmc An RNA-binding protein, hnRNP A1, and a scaffold protein, septin 6, facilitate hepatitis C virus replication
    Chon Saeng Kim
    PBC, Department of Life Science, Pohang University of Science and Technology, San 31, Hyoja Dong, Pohang 790 784, Republic of Korea
    J Virol 81:3852-65. 2007
    ..These results indicate that the host proteins hnRNP A1 and septin 6 play important roles in the replication of HCV through RNA-protein and protein-protein interactions...
  30. ncbi request reprint Continuous heat shock enhances translational initiation directed by internal ribosomal entry site
    Yoon Ki Kim
    NRL, Division of Molecular and Life Sciences, Department of Life Science, Pohang University of Science and Technology, San31, Hyoja Dong, Pohang, Kyungbuk 790 784, Republic of Korea
    Biochem Biophys Res Commun 297:224-31. 2002
    ..Taken together, these results indicate that the mechanism of IRES-dependent translation can be used during heat shock and suggest that this translational mechanism may be critical to the survival and proliferation of cells under stress...
  31. pmc Monitoring the antiviral effect of alpha interferon on individual cells
    Chon Saeng Kim
    PBC, Department of Life Science, Pohang University of Science and Technology, San31, Hyoja Dong, Pohang 790 784, Republic of Korea
    J Virol 81:8814-20. 2007
    ..Responses of individual cells containing HCV to alpha interferon (IFN-alpha) were monitored using GFP-tagged HCV and time-lapse confocal microscopy. Marked variations in the response to IFN-alpha were observed among HCV-containing cells...
  32. doi request reprint Infectivity of hepatitis C virus correlates with the amount of envelope protein E2: development of a new aptamer-based assay system suitable for measuring the infectious titer of HCV
    Ji Hoon Park
    Molecular Virology Laboratory, Postech Biotech Center, Department of Life Science, Pohang University of Science and Technology, San 31, Hyoja Dong, Nam Gu, Pohang, Kyungbuk 790 784, Republic of Korea
    Virology 439:13-22. 2013
    ..We also demonstrated that the activities of anti-HCV drugs can be monitored by HCV ELASA. Therefore, HCV ELASA is a quick-and-easy method to quantify infectious units of HCV stocks and to monitor efficacies of potential anti-HCV drugs...
  33. pmc Rhythmic serotonin N-acetyltransferase mRNA degradation is essential for the maintenance of its circadian oscillation
    Tae Don Kim
    National Research Laboratory, Department of Life Science, Pohang University of Science and Technology, San 31 Hyoja Dong, Pohang, Kyung Buk 790 784, Republic of Korea
    Mol Cell Biol 25:3232-46. 2005
    ....
  34. pmc An mRNA-specific tRNAi carrier eIF2A plays a pivotal role in cell proliferation under stress conditions: stress-resistant translation of c-Src mRNA is mediated by eIF2A
    Oh Sung Kwon
    Molecular Virology Laboratory, Postech Biotech Center, Department of Life Sciences, Pohang University of Science and Technology, Pohang, Korea
    Nucleic Acids Res . 2016
    ..Finally, we showed that the eIF2A-dependent translation of c-Src mRNA plays a pivotal role in cell proliferation under stress conditions...
  35. pmc Cap-dependent translation without base-by-base scanning of an messenger ribonucleic acid
    Ki Young Paek
    PBC, Department of Life Science, Pohang University of Science and Technology, San 31, Hyoja Dong, Nam Gu, Pohang, Kyungbuk 790 784, Republic of Korea
    Nucleic Acids Res 40:7541-51. 2012
    ..These data indicate that a ribosome may skip part(s) of an messenger RNA 5'UTR without thoroughly scanning it...
  36. pmc Generation of a cell culture-adapted hepatitis C virus with longer half life at physiological temperature
    Chon Saeng Kim
    Molecular Virology Laboratory, Postech Biotech Center, Department of Life Science, Pohang University of Science and Technology, Pohang, Kyungbuk, Republic of Korea
    PLoS ONE 6:e22808. 2011
    ..Although these viruses were useful in monitoring viral proliferation and screening of anti-HCV drugs, the infectivity and yield of the viruses were low...
  37. doi request reprint Hepatitis C virus (HCV) genotyping by annealing reverse transcription-PCR products with genotype-specific capture probes
    Jungmin Rho
    Panbionet, Corp, Postech Biotech Center, Pohang 790 784, Republic of Korea
    J Microbiol 46:81-7. 2008
    ..These results collectively indicate that AGSCP assay is a convenient and sensitive method for large-scale genotyping, and it may be a promising tool for the determination of HCV and other genotypes in clinical settings...
  38. pmc Protein localization as a principal feature of the etiology and comorbidity of genetic diseases
    Solip Park
    School of Interdisciplinary Bioscience and Bioengineering, Pohang University of Science and Technology, Pohang, Korea
    Mol Syst Biol 7:494. 2011
    ..Our result establishes a direct correlation between protein subcellular localization and disease association, and helps to understand the mechanism of human disease progression...
  39. doi request reprint The bent conformation of poly(A)-binding protein induced by RNA-binding is required for its translational activation function
    Ka Young Hong
    a Department of Life Sciences, Pohang University of Science and Technology POSTECH, Pohang, Gyeongbuk, 790 784, South Korea
    RNA Biol . 2017
    ..The preferential binding of the eIF4G/eIF4E complex to the bent PABP/poly(A) complex seems to be a mechanism discriminating the mRNA-bound PABPs participating in translation from the idling mRNA-unbound PABPs...
  40. ncbi request reprint Domains I and II in the 5' nontranslated region of the HCV genome are required for RNA replication
    Yoon Ki Kim
    Department of Life Science, Division of Molecular and Life Sciences, Pohang University of Science and Technology, San31, Hyoja Dong, Pohang, Kyungbuk 790 784, Korea
    Biochem Biophys Res Commun 290:105-12. 2002
    ..This indicates that domains I and II are necessary and sufficient for replication of RNA and that almost all of the 5'NTR is required for efficient RNA replication...
  41. pmc Poly(A) RNA and Paip2 act as allosteric regulators of poly(A)-binding protein
    Seung Hwan Lee
    School of Interdisciplinary Bioscience and Bioengineering, Pohang University of Science and Technology POSTECH, Pohang 790 784, Korea, Department of Physics, Pohang University of Science and Technology POSTECH, Pohang 790 784, Korea, Department of Life Sciences, Pohang University of Science and Technology POSTECH, Pohang 790 784, Korea and Division of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology POSTECH, Pohang 790 784, Korea
    Nucleic Acids Res 42:2697-707. 2014
    ..These results suggest that the changes in the configuration of PABP induced by interactions with various effector molecules, such as poly(A) and PABP-interacting protein 2, play pivotal roles in its function. ..
  42. pmc Sequestration of TRAF2 into stress granules interrupts tumor necrosis factor signaling under stress conditions
    Woo Jae Kim
    National Research Laboratory, Postech Biotech Center, Department of Life Science, Division of Molecular and Life Sciences, Pohang University of Science and Technology, Hyoja Dong San 31, Pohang, Kyungbuk 790 784, Korea
    Mol Cell Biol 25:2450-62. 2005
    ..This suggests that stressed cells lower their biological activities by sequestration of translation factors and TRAF2 into SGs through a protein-protein interaction...
  43. doi request reprint Heat shock factor 1 mediates the longevity conferred by inhibition of TOR and insulin/IGF-1 signaling pathways in C. elegans
    Keunhee Seo
    Department of Life Sciences, Pohang University of Science and Technology, Pohang, Kyungbuk, 790 784, Korea
    Aging Cell 12:1073-81. 2013
    ..Our findings suggest that HSF-1 acts as an essential longevity factor that intersects both IIS and TOR signaling pathways. ..
  44. pmc Crif1 is a novel transcriptional coactivator of STAT3
    Min Chul Kwon
    Department of Life Science, Division of Molecular and Life Sciences, Pohang University of Science and Technology, Pohang, South Korea
    EMBO J 27:642-53. 2008
    ..Our results reveal that Crif1 is a novel and essential transcriptional coactivator of STAT3 that modulates its DNA binding ability, and shed light on the regulation of oncogenic STAT3...
  45. pmc Crystal structure of the eIF4A-PDCD4 complex
    Jeong Ho Chang
    National Creative Initiatives for Structural Biology and Department of Life Science, Pohang University of Science and Technology, Hyo ja dong, San31, Pohang, KyungBook, South Korea
    Proc Natl Acad Sci U S A 106:3148-53. 2009
    ..The structure, together with biochemical analyses, reveals insights into the inhibition mechanism of eIF4A by PDCD4 and provides a framework for designing chemicals that target eIF4A...
  46. pmc Cap-dependent translation is mediated by 'RNA looping' rather than 'ribosome scanning'
    Sung Key Jang
    a Department of Life Sciences, Pohang University of Science and Technology, Nam Gu, Pohang si, Gyeongsangbuk do, Republic of Korea
    RNA Biol 13:1-5. 2016
    ....
  47. pmc Agonistic aptamer to the insulin receptor leads to biased signaling and functional selectivity through allosteric modulation
    Na Oh Yunn
    The School of Interdisciplinary Bioscience and Bioengineering, Pohang University of Science and Technology, Pohang 790 784, South Korea
    Nucleic Acids Res 43:7688-701. 2015
    ..Furthermore, our study also suggests that aptamers can be a promising tool for developing artificial biased agonists to targeted receptors. ..
  48. ncbi request reprint Cholesterol-linked fluorescent molecular beacons with enhanced cell permeability
    Young Jun Seo
    National Research Laboratory, Department of Chemistry, Pohang University of Science and Technology, San 31 Hyoja Dong, Pohang 790 784, Korea
    Bioconjug Chem 17:1151-5. 2006
    ..These structurally simple cholesterol-based MB systems, which can be synthesized very efficiently, have good potential for opening up new and exciting opportunities in the field of in vivo biosensors...
  49. doi request reprint Construction of functional interaction networks through consensus localization predictions of the human proteome
    Solip Park
    School of Interdisciplinary Bioscience and Bioengineering, Pohang University of Science and Technology, Pohang 790 784, Korea
    J Proteome Res 8:3367-76. 2009
    ..Thus, the use of consensus localization prediction, such as ConLoc, is a new approach for the identification of novel disease associated genes...
  50. doi request reprint Iron increases translation initiation directed by internal ribosome entry site of hepatitis C virus
    Hana Cho
    School of Life Sciences and Biotechnology, Korea University, Seoul, 136 701, Republic of Korea
    Virus Genes 37:154-60. 2008
    ..As a consequence, the coordinated regulation of gene expression by intracellular iron could provide favorable conditions for HCV proliferation...
  51. pmc Isolation of specific and high-affinity RNA aptamers against NS3 helicase domain of hepatitis C virus
    Byounghoon Hwang
    Department of Molecular Biology, Institute of Nanosensor and Biotechnology, Dankook University, San8 Hannam Dong, Yongsan gu, Seoul 140 714, Korea
    RNA 10:1277-90. 2004
    ..These results suggest that the RNA aptamers selected in vitro could be useful not only as therapeutic and diagnostic agents of HCV infection but also as a powerful tool for the study of HCV helicase mechanism...
  52. ncbi request reprint Replication of a novel subgenomic HCV genotype 1a replicon expressing a puromycin resistance gene in Huh-7 cells
    Chengyu Liang
    Department of Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, NY 11790, USA
    Virology 333:41-53. 2005
    ..The data identify PAC as an efficient selectable marker for studies of HCV replication, which may be useful with different genotypes in different host cell systems...
  53. ncbi request reprint NIP1/XB51/NECAB3 is a potential substrate of Nek2, suggesting specific roles of Nek2 in Golgi
    Jae Cheal Yoo
    School of Biological Sciences, Seoul National University, Seoul, 151 742, Korea
    Exp Cell Res 292:393-402. 2004
    ..These results propose a possible involvement of Nek2 in biological processes of the Golgi body, perhaps in relation to the inheritance of Golgi during mitosis or to cell cycle stage-specific regulation of exocytosis...
  54. ncbi request reprint Synthesis of 2-C-hydroxymethylribofuranosylpurines as potent anti-hepatitis C virus (HCV) agents
    Byul Nae Yoo
    Laboratory of Medicinal Chemistry, College of Pharmacy, Ewha Womans University, Seoul, Republic of Korea
    Bioorg Med Chem Lett 16:4190-4. 2006
    ..Among compounds tested, adenosine derivative 2a exhibited potent anti-HCV activity, indicating that the hydroxyl group of 2'-C-hydroxymethyl substituent led to favorable interaction with HCV polymerase...
  55. ncbi request reprint Hepatitis C virus NS2 protein activates cellular cyclic AMP-dependent pathways
    Kyoung Mi Kim
    School of Life Sciences and Biotechnology, Korea University, Seoul 136 701, Republic of Korea
    Biochem Biophys Res Commun 356:948-54. 2007
    ..These results allude to the HCV NS2 protein having a novel function of regulating cellular gene expression and proliferation through the cAMP-dependent pathway...