Junsang Doh

Summary

Affiliation: Pohang University of Science and Technology
Country: Korea

Publications

  1. doi request reprint Immunological synapses within context: patterns of cell-cell communication and their application in T-T interactions
    Junsang Doh
    School of Interdisciplinary Bioscience and Bioengineering and Department of Mechanical Engineering, Pohang University of Science and Technology, Hyoja Dong, Nam Gu, Pohang, Gyeongbuk, Korea
    Curr Top Microbiol Immunol 340:25-50. 2010
  2. doi request reprint T cells sense biophysical cues using lamellipodia and filopodia to optimize intraluminal path finding
    Kwang Hoon Song
    Department of Mechanical Engineering, Pohang University of Science and Technology POSTECH, San 31, Hyoja Dong, Nam Gu, Pohang, Gyeongbuk 790 784, Korea
    Integr Biol (Camb) 6:450-9. 2014
  3. doi request reprint Cell-laden microwells for the study of multicellularity in lymphocyte fate decisions
    Junsang Doh
    School of Interdisciplinary Bioscience and Bioengineering, Pohang University of Science and Technology, Pohang, Gyeongbuk, Republic of Korea
    Biomaterials 31:3422-8. 2010
  4. doi request reprint Nanotopography-guided migration of T cells
    Keon Woo Kwon
    Department of Mechanical Engineering, Pohang University of Science and Technology, Hyoja Dong, Nam Gu, Pohang, Gyeongbuk 790 784, Korea
    J Immunol 189:2266-73. 2012
  5. doi request reprint PDMS bonding to a bio-friendly photoresist via self-polymerized poly(dopamine) adhesive for complex protein micropatterning inside microfluidic channels
    Miju Kim
    School of Interdisciplinary Bioscience and Bioengineering I Bio, Pohang University of Science and Technology, Pohang, Gyeongbuk 790 784, Republic of Korea
    Colloids Surf B Biointerfaces 112:134-8. 2013
  6. pmc Migration of T cells on surfaces containing complex nanotopography
    Keon Woo Kwon
    Department of Mechanical Engineering, Pohang University of Science and Technology POSTECH, Pohang, Republic of Korea
    PLoS ONE 8:e73960. 2013
  7. doi request reprint High-throughput quantitative imaging of cell spreading dynamics by multi-step microscopy projection photolithography based on a cell-friendly photoresist
    Jong Cheol Choi
    Department of Mechanical Engineering, POSTECH, San31, Hyoja Dong, Nam Gu, Pohang, 790 784, Gyeongbuk, Korea
    Lab Chip 12:4964-7. 2012
  8. doi request reprint Dynamic Micropatterning of Cells on Nanostructured Surfaces Using a Cell-friendly Photoresist
    SoonHo Kweon
    School of Interdisciplinary Bioscience and Bioengineering I Bio and Department of Mechanical Engineering, Pohang University of Science and Technology, San31, Hyoja Dong, Nam Gu, Pohang, Gyeongbuk 790 784, South Korea
    ACS Appl Mater Interfaces 8:4266-74. 2016
  9. pmc Roles of endothelial A-type lamins in migration of T cells on and under endothelial layers
    Kwang Hoon Song
    Department of Mechanical Engineering, Pohang University of Science and Technology POSTECH San 31, Hyoja Dong, Nam Gu, Pohang, Gyeongbuk, 790 784, Korea
    Sci Rep 6:23412. 2016
  10. doi request reprint Dynamics of T cells on endothelial layers aligned by nanostructured surfaces
    Kwang Hoon Song
    Department of Mechanical Engineering, Pohang University of Science and Technology POSTECH, San 31, Hyoja Dong, Nam Gu, Pohang, Gyeongbuk 790 784, South Korea
    Biomaterials 33:2007-15. 2012

Collaborators

  • Matthew F Krummel
  • Kyung Mi Lee
  • Min Su Kim
  • Dong Woo Cho
  • Sukhyun Song
  • Kwang Hoon Song
  • Jong Cheol Choi
  • Keon Woo Kwon
  • Hong Ryul Jung
  • Hyoungjun Park
  • Kyoung Duck Seo
  • Dong Sung Kim
  • Kahp Yang Suh
  • Jaehyun Lee
  • SoonHo Kweon
  • Hyeokjun Byeon
  • Ju Young Park
  • Seong Jeong Park
  • Jiwoo Kang
  • Hye Mi Kim
  • Andrew Choi
  • Sang Joon Lee
  • Jeehun Park
  • Sung Jea Park
  • Jaehwang Jung
  • John T Chang
  • Yunji Park
  • Young Chul Sung
  • Yongkeun Park
  • Hong Namkoong
  • Bo Gie Yang
  • Sung Won Kim
  • Jung Seob Lee
  • Jin Hyung Shim
  • Wonhwa Cho
  • Moon Jeong Park
  • Hyungmin Ahn

Detail Information

Publications23

  1. doi request reprint Immunological synapses within context: patterns of cell-cell communication and their application in T-T interactions
    Junsang Doh
    School of Interdisciplinary Bioscience and Bioengineering and Department of Mechanical Engineering, Pohang University of Science and Technology, Hyoja Dong, Nam Gu, Pohang, Gyeongbuk, Korea
    Curr Top Microbiol Immunol 340:25-50. 2010
    ..We postulate that the patterns are fine-tuned to provide quorum-like decisions by collections of activating and activated cells that interact over time and space...
  2. doi request reprint T cells sense biophysical cues using lamellipodia and filopodia to optimize intraluminal path finding
    Kwang Hoon Song
    Department of Mechanical Engineering, Pohang University of Science and Technology POSTECH, San 31, Hyoja Dong, Nam Gu, Pohang, Gyeongbuk 790 784, Korea
    Integr Biol (Camb) 6:450-9. 2014
    ..Lamellipodia or filopodia-inhibited T cells crawled significantly longer distances for extravasation than did normal T cells, indicating that sensing biophysical cues are critical for optimizing routes for extravasation. ..
  3. doi request reprint Cell-laden microwells for the study of multicellularity in lymphocyte fate decisions
    Junsang Doh
    School of Interdisciplinary Bioscience and Bioengineering, Pohang University of Science and Technology, Pohang, Gyeongbuk, Republic of Korea
    Biomaterials 31:3422-8. 2010
    ..Different types of fate decisions for activating T cells can be shown to variously obey 'binary' or 'density' outcomes, correlated with cell-cell contact, using this new platform...
  4. doi request reprint Nanotopography-guided migration of T cells
    Keon Woo Kwon
    Department of Mechanical Engineering, Pohang University of Science and Technology, Hyoja Dong, Nam Gu, Pohang, Gyeongbuk 790 784, Korea
    J Immunol 189:2266-73. 2012
    ....
  5. doi request reprint PDMS bonding to a bio-friendly photoresist via self-polymerized poly(dopamine) adhesive for complex protein micropatterning inside microfluidic channels
    Miju Kim
    School of Interdisciplinary Bioscience and Bioengineering I Bio, Pohang University of Science and Technology, Pohang, Gyeongbuk 790 784, Republic of Korea
    Colloids Surf B Biointerfaces 112:134-8. 2013
    ..The technique developed in this study will be useful for the fabrication of complex biochips for multiplex bioassays and fundamental cell biological studies. ..
  6. pmc Migration of T cells on surfaces containing complex nanotopography
    Keon Woo Kwon
    Department of Mechanical Engineering, Pohang University of Science and Technology POSTECH, Pohang, Republic of Korea
    PLoS ONE 8:e73960. 2013
    ..This result suggests that thin, wide lamellipodia at the leading edges of T cells play critical roles in motility of T cells in complex topographical microenvironments. ..
  7. doi request reprint High-throughput quantitative imaging of cell spreading dynamics by multi-step microscopy projection photolithography based on a cell-friendly photoresist
    Jong Cheol Choi
    Department of Mechanical Engineering, POSTECH, San31, Hyoja Dong, Nam Gu, Pohang, 790 784, Gyeongbuk, Korea
    Lab Chip 12:4964-7. 2012
    ..By releasing a large number of rounded cells in single cell arrays and monitoring their spreading dynamics by interference reflection microscopy, a large number of cell spreading data can be acquired by a single experiment...
  8. doi request reprint Dynamic Micropatterning of Cells on Nanostructured Surfaces Using a Cell-friendly Photoresist
    SoonHo Kweon
    School of Interdisciplinary Bioscience and Bioengineering I Bio and Department of Mechanical Engineering, Pohang University of Science and Technology, San31, Hyoja Dong, Nam Gu, Pohang, Gyeongbuk 790 784, South Korea
    ACS Appl Mater Interfaces 8:4266-74. 2016
    ..This method will allow many exciting opportunities in the fundamental study of cellular dynamics. ..
  9. pmc Roles of endothelial A-type lamins in migration of T cells on and under endothelial layers
    Kwang Hoon Song
    Department of Mechanical Engineering, Pohang University of Science and Technology POSTECH San 31, Hyoja Dong, Nam Gu, Pohang, Gyeongbuk, 790 784, Korea
    Sci Rep 6:23412. 2016
    ..This result suggests that EC nuclear stiffness promotes fast and directionally persistent subendothelial migration of T cells by allowing minimum interaction between T cells and EC nuclei. ..
  10. doi request reprint Dynamics of T cells on endothelial layers aligned by nanostructured surfaces
    Kwang Hoon Song
    Department of Mechanical Engineering, Pohang University of Science and Technology POSTECH, San 31, Hyoja Dong, Nam Gu, Pohang, Gyeongbuk 790 784, South Korea
    Biomaterials 33:2007-15. 2012
    ..This result will suggest a new strategy for the design of synthetic small diameter vascular grafts and extend our current knowledge of leukocyte dynamics on an inflamed endothelium...
  11. doi request reprint Photopatterning with a printed transparency mask and a protein-friendly photoresist
    Jiwoo Kang
    School of Interdisciplinary Bioscience and Bioengineering I Bio, Pohang University of Science and Technology, Pohang, Gyeongbuk, South Korea
    Methods Cell Biol 119:55-72. 2014
    ..In addition, we describe the protocols used in the micropatterning of multiple lymphocytes and the dynamic micropatterning of adherent cells...
  12. pmc Synthesis of Poly(N-isopropylacrylamide) Janus Microhydrogels for Anisotropic Thermo-responsiveness and Organophilic/Hydrophilic Loading Capability
    Kyoung Duck Seo
    Department of Mechanical Engineering, Pohang University of Science and Technology POSTECH
    J Vis Exp . 2016
    ..We believe that the proposed method introduces a novel hydrogel platform with the potential for advanced synthesis of multi-functional Janus microhydrogels. ..
  13. pmc Multi-cellular natural killer (NK) cell clusters enhance NK cell activation through localizing IL-2 within the cluster
    Miju Kim
    School of Interdisciplinary Bioscience and Bioengineering I Bio, Pohang University of Science and Technology, Pohang, Gyeongbuk 790 784, Korea
    Sci Rep 7:40623. 2017
    ..These data highlights the existence of IL-2 trans-presentation between NK cells in the local microenvironment where the availability of IL-2 is limited...
  14. doi request reprint A comparative study on collagen type I and hyaluronic acid dependent cell behavior for osteochondral tissue bioprinting
    Ju Young Park
    Division of Integrative Biosciences and Biotechnology, POSTECH, Pohang, Korea
    Biofabrication 6:035004. 2014
    ..These results suggest that with proper choice of hydrogel materials, bioprinting-based approaches can be successfully applied for osteochondral tissue regeneration...
  15. doi request reprint Sinusoidal wavy surfaces for curvature-guided migration of T lymphocytes
    Kwang Hoon Song
    Department of Mechanical Engineering, Pohang University of Science and Technology POSTECH, San31, Hyoja Dong, Nam Gu, Pohang, Gyeongbuk, 790 784, Republic of Korea
    Biomaterials 51:151-60. 2015
    ....
  16. pmc Geometrically controlled asymmetric division of CD4+ T cells studied by immunological synapse arrays
    Hong Ryul Jung
    School of Interdisciplinary Bioscience and Bioengineering I Bio, Pohang University of Science and Technology POSTECH, Pohang, Korea
    PLoS ONE 9:e91926. 2014
    ....
  17. doi request reprint Microfabricated platforms to modulate and monitor T cell synapse assembly
    Hong Ryul Jung
    School of Interdisciplinary Bioscience and Bioengineering I Bio, Pohang University of Science and Technology POSTECH, Pohang, Gyeongbuk, South Korea
    Wiley Interdiscip Rev Nanomed Nanobiotechnol 5:67-74. 2013
    ..Secondly, micropatterned supported bilayers that can modulate the dynamics of T cell receptor (TCR) microclusters are introduced. Lastly, T-APC pair arrays that allow for improved fluorescence live cell imaging are discussed...
  18. doi request reprint Dynamic modulation of small-sized multicellular clusters using a cell-friendly photoresist
    Jong Cheol Choi
    Department of Mechanical Engineering, School of Interdisciplinary Bioscience and Bioengineering I Bio, Pohang University of Science and Technology, San31, Hyoja Dong, Nam Gu, Pohang, Gyeongbuk, 790 784, Korea
    ACS Appl Mater Interfaces 5:12757-63. 2013
    ..The method developed in the study will be useful for the study of collective migration and multicellular dynamics. ..
  19. pmc Hybrid bright-field and hologram imaging of cell dynamics
    Hyeokjun Byeon
    Center for Biofluid and Biomimic Research, Department of Mechanical Engineering, Pohang University of Science and Technology POSTECH, Pohang, 790 784, South Korea
    Sci Rep 6:33750. 2016
    ..The developed system was successfully applied to capture distinct T-cell adhesion dynamics on inflamed endothelial layers, including capture, rolling, crawling, transendothelial migration, and subendothelial migration. ..
  20. doi request reprint Simple and Sensitive Point-of-Care Bioassay System Based on Hierarchically Structured Enzyme-Mimetic Nanoparticles
    Miju Kim
    Department of Mechanical Engineering, Pohang University of Science and Technology POSTECH, Pohang, Gyeongbuk, 790 784, Republic of Korea
    Adv Healthc Mater 4:1311-6. 2015
    ..Using this new device, quantitative analysis of liquid sample is performed within 15 min with an order of magnitude enhancement of sensitivity compared with conventional Au nanoparticle-based devices. ..
  21. doi request reprint One-step microfluidic synthesis of Janus microhydrogels with anisotropic thermo-responsive behavior and organophilic/hydrophilic loading capability
    Kyoung Duck Seo
    Department of Mechanical Engineering, Pohang University of Science and Technology POSTECH, 77 Cheongam ro, Nam Gu, Pohang, Gyungbuk 790 784, South Korea
    Langmuir 29:15137-41. 2013
    ..The resulting Janus microhydrogels exhibited tunable anisotropic thermo-responsive behavior and organophilic/hydrophilic loading capability. ..
  22. doi request reprint Negative role of inducible PD-1 on survival of activated dendritic cells
    Seong Jeong Park
    1 Pohang University of Science and Technology POSTECH, San 31 Hyoja Dong, Namgu, Pohang, Korea
    J Leukoc Biol 95:621-9. 2014
    ..Taken together, our findings further extend the function of PD-1, which plays an important role in apoptosis of activated DCs and provides important implications for PD-1-mediated immune regulation. ..
  23. doi request reprint Addressable micropatterning of multiple proteins and cells by microscope projection photolithography based on a protein friendly photoresist
    Miju Kim
    School of Interdisciplinary Bioscience and Bioengineering, Pohang University of Science and Technology, San31, Hyoja Dong, Nam Gu, Pohang, Gyeongbuk, 790 784, Korea
    Langmuir 26:12112-8. 2010
    ..This technique will in general be useful for protein chip fabrication and high-throughput cell-cell communication study...