Kwang Hyun Baek

Summary

Affiliation: Pochon CHA University
Country: Korea

Publications

  1. ncbi request reprint Essential regions of deubiquitinating enzyme activity and enhancer function for DUB-2A expressed in T-lymphocytes
    Kwang Hyun Baek
    Cell and Gene Therapy Research Institute, Pochon CHA University, CHA General Hospital, Seoul, Republic of Korea
    Arch Biochem Biophys 430:191-7. 2004
  2. ncbi request reprint Molecular genetics of polycystic ovary syndrome: an update
    L Li
    Department of Biomedical Science, CHA University, Bundang CHA General Hospital, Bundang gu, Seongnam si, Gyeonggi do 463 400, Republic of Korea
    Curr Mol Med 15:331-42. 2015
  3. pmc Embryonic demise caused by targeted disruption of a cysteine protease Dub-2
    Kwang Hyun Baek
    Department of Biomedical Science, CHA Stem Cell Institute, CHA University, CHA General Hospital, Gyeonggi Do, Republic of Korea
    PLoS ONE 7:e44223. 2012
  4. ncbi request reprint Molecular cloning and characterization of bovine bgl-1, a novel family member of WD-40 repeat-containing lethal giant larvae tumor suppressor genes
    Kwang Hyun Baek
    College of Medicine, Cell and Gene Therapy Research Institute, Pochon CHA University, CHA General Hospital, Seoul, Korea 135 081
    Int J Oncol 20:739-44. 2002
  5. ncbi request reprint Comparison of gene expression at the feto-maternal interface between normal and recurrent pregnancy loss patients
    Kwang Hyun Baek
    College of Medicine, Pochon CHA University, Infertility Medical Center, CHA General Hospital, Kangnam Gu, Seoul, Korea
    Reprod Fertil Dev 14:235-40. 2002
  6. ncbi request reprint Molecular cloning and complete cDNA sequence of UBH1 in mouse testis
    Kwang Hyun Baek
    College of Medicine, Pochon CHA University, Cell and Gene Therapy Research Institute, CHA General Hospital, Seoul, South Korea
    DNA Seq 13:145-8. 2002
  7. ncbi request reprint Lymphocyte-specific murine deubiquitinating enzymes induced by cytokines
    Kwang Hyun Baek
    Department of Microbiology, College of Medicine, Pochon CHA University, Cell and Gene Therapy Research Institute, CHA General Hospital, Kangnam Gu, Seoul, Korea
    Am J Hematol 71:340-5. 2002
  8. ncbi request reprint Conjugation and deconjugation of ubiquitin regulating the destiny of proteins
    Kwang Hyun Baek
    Department of Microbiology College of Medicine, Pochon CHA University Cell and Gene Therapy Research Institute CHA General Hospital, Seoul 135 081, Korea
    Exp Mol Med 35:1-7. 2003
  9. ncbi request reprint Molecular cloning of rHAUSP encoding a deubiquitinating enzyme in rat testis
    Kwang Hyun Baek
    Graduate School of Life Science and Biotechnology, Pochon CHA University, Korea
    Oncol Rep 15:173-7. 2006
  10. ncbi request reprint DUB-1A, a novel deubiquitinating enzyme subfamily member, is polyubiquitinated and cytokine-inducible in B-lymphocytes
    Kwang Hyun Baek
    Cell and Gene Therapy Research Institute, Graduate School of Life Science and Biotechnology, Pochon CHA University, CHA General Hospital, Seoul, Korea
    J Biol Chem 279:2368-76. 2004

Collaborators

Detail Information

Publications85

  1. ncbi request reprint Essential regions of deubiquitinating enzyme activity and enhancer function for DUB-2A expressed in T-lymphocytes
    Kwang Hyun Baek
    Cell and Gene Therapy Research Institute, Pochon CHA University, CHA General Hospital, Seoul, Republic of Korea
    Arch Biochem Biophys 430:191-7. 2004
    ..Taken all together, these results will be very helpful in designing activators or inhibitors of this enzyme in order to regulate its expression and catalytic activity in T-lymphocytes...
  2. ncbi request reprint Molecular genetics of polycystic ovary syndrome: an update
    L Li
    Department of Biomedical Science, CHA University, Bundang CHA General Hospital, Bundang gu, Seongnam si, Gyeonggi do 463 400, Republic of Korea
    Curr Mol Med 15:331-42. 2015
    ....
  3. pmc Embryonic demise caused by targeted disruption of a cysteine protease Dub-2
    Kwang Hyun Baek
    Department of Biomedical Science, CHA Stem Cell Institute, CHA University, CHA General Hospital, Gyeonggi Do, Republic of Korea
    PLoS ONE 7:e44223. 2012
    ..DUB-2 presumably removes ubiquitin from ubiquitin-conjugated target proteins regulating ubiquitin-mediated proteolysis, but its specific target proteins are unknown yet...
  4. ncbi request reprint Molecular cloning and characterization of bovine bgl-1, a novel family member of WD-40 repeat-containing lethal giant larvae tumor suppressor genes
    Kwang Hyun Baek
    College of Medicine, Cell and Gene Therapy Research Institute, Pochon CHA University, CHA General Hospital, Seoul, Korea 135 081
    Int J Oncol 20:739-44. 2002
    ..The complementation analysis revealed that the bovine bgl-1 partially restored the Na+ tolerance in the absence of yeast lgl homologue, suggesting that bgl-1 is a bovine homologue of the lgl family...
  5. ncbi request reprint Comparison of gene expression at the feto-maternal interface between normal and recurrent pregnancy loss patients
    Kwang Hyun Baek
    College of Medicine, Pochon CHA University, Infertility Medical Center, CHA General Hospital, Kangnam Gu, Seoul, Korea
    Reprod Fertil Dev 14:235-40. 2002
    ..Eight genes classified into groups, including immunosuppression-related, embryo attachment-related and angiogenesis-related, were isolated...
  6. ncbi request reprint Molecular cloning and complete cDNA sequence of UBH1 in mouse testis
    Kwang Hyun Baek
    College of Medicine, Pochon CHA University, Cell and Gene Therapy Research Institute, CHA General Hospital, Seoul, South Korea
    DNA Seq 13:145-8. 2002
    ..Biochemical assay revealed that the mouse UBH1 has deubiquitinating enzyme activity and sequence analysis showed 98.3% amino acid identity with human UBH1...
  7. ncbi request reprint Lymphocyte-specific murine deubiquitinating enzymes induced by cytokines
    Kwang Hyun Baek
    Department of Microbiology, College of Medicine, Pochon CHA University, Cell and Gene Therapy Research Institute, CHA General Hospital, Kangnam Gu, Seoul, Korea
    Am J Hematol 71:340-5. 2002
    ..A number of deubiquitinating enzymes have been isolated even though little is known about their biological functions. This review concentrates on recent findings and new insights into DUB enzyme subfamily members in lymphocytes...
  8. ncbi request reprint Conjugation and deconjugation of ubiquitin regulating the destiny of proteins
    Kwang Hyun Baek
    Department of Microbiology College of Medicine, Pochon CHA University Cell and Gene Therapy Research Institute CHA General Hospital, Seoul 135 081, Korea
    Exp Mol Med 35:1-7. 2003
    ..Isolation of all putative DUBs will help to identify their substrates and to regulate the homeostasis of cellular proteins, especially in proliferative cells...
  9. ncbi request reprint Molecular cloning of rHAUSP encoding a deubiquitinating enzyme in rat testis
    Kwang Hyun Baek
    Graduate School of Life Science and Biotechnology, Pochon CHA University, Korea
    Oncol Rep 15:173-7. 2006
    ..pI value of rHAUSP is 5.31. In vivo and in vitro deubiquitinating enzyme assays demonstrated that rHAUSP has deubiquitinating enzymatic activity. The over-expression of rHAUSP induced cell death of cervical adenocarcinoma cells...
  10. ncbi request reprint DUB-1A, a novel deubiquitinating enzyme subfamily member, is polyubiquitinated and cytokine-inducible in B-lymphocytes
    Kwang Hyun Baek
    Cell and Gene Therapy Research Institute, Graduate School of Life Science and Biotechnology, Pochon CHA University, CHA General Hospital, Seoul, Korea
    J Biol Chem 279:2368-76. 2004
    ..In the absence of JAK2, Dub-1A was expressed at a lower level. This suggests that DUB-1A functions downstream of JAK2 kinase in the interleukin-3 signaling pathway...
  11. ncbi request reprint Recurrent pregnancy loss: the key potential mechanisms
    Kwang Hyun Baek
    Graduate School of Life Science and Biotechnology, Cell and Gene Therapy Research Institute, Pochon CHA University, CHA General Hospital, Seoul 135 081, South Korea
    Trends Mol Med 13:310-7. 2007
    ..Taken together, these findings provide insight into the development of effective therapeutics for RPL...
  12. ncbi request reprint Pro12Ala and His447His polymorphisms of PPAR-gamma are associated with polycystic ovary syndrome
    Bon Hee Gu
    Cell and Gene Therapy Research, Institute, Fertility Medical Centre, CHA University, CHA General Hospital, Seoul, Korea
    Reprod Biomed Online 18:644-50. 2009
    ..This study has shown that both Pro12Ala and His447His polymorphisms of PPAR-gamma are associated with PCOS in a Korean population...
  13. ncbi request reprint Cytokine-regulated protein degradation by the ubiquitination system
    Kwang Hyun Baek
    Cell and Gene Therapy Research Institute, Graduate School of Life Science and Biotechnology, Pochon CHA University, CHA General Hospital, Seoul 135 081, Korea
    Curr Protein Pept Sci 7:171-7. 2006
    ..This review introduces the reader to provide a great understanding of cytokine-inducible DUB enzymes in both mouse and human, and new insights into DUB subfamily members...
  14. ncbi request reprint Aberrant gene expression associated with recurrent pregnancy loss
    Kwang Hyun Baek
    Cell and Gene Therapy Research Institute, Infertility Medical Center, Pochon CHA University, CHA General Hospital, 605 Yeoksam 1 dong, Kangnam Gu, Seoul 135 081, Korea
    Mol Hum Reprod 10:291-7. 2004
    ..In this review, recent study on aberrant expression levels of genes, which are grouped as immunity-related, angiogenesis-related, apoptosis-related and other groups of genes, will be discussed...
  15. ncbi request reprint Structural and functional conservation of the lgl recessive oncogenes (Review)
    Kwang Hyun Baek
    Cell and Gene Therapy Research Institute, College of Medicine, Pochon CHA University, CHA General Hospital, Seoul 135 081, Korea
    Int J Oncol 24:1257-61. 2004
    ..This review introduces the possibility that studies with lethal giant larvae (lgl) tumor suppressor family members can provide a better understanding of their functional roles during tumor development in eukaryotic cells...
  16. ncbi request reprint Expression and functional analyses of mHAUSP regulating apoptosis of cervical adenocarcinoma cells
    Kyong Jai Yoo
    Graduate School of Life Science and Biotechnology, Seoul, Korea
    Int J Oncol 27:97-104. 2005
    ..However, other conserved amino acids were required for deubiquitinating enzyme activity of mHAUSP. Moreover, we observed that the overexpression of mHAUSP induces cell death in HeLa cells...
  17. ncbi request reprint The expression patterns of deubiquitinating enzymes, USP22 and Usp22
    Hey Jin Lee
    Cell and Gene Therapy Research Institute, Graduate School of Life Science and Biotechnology, Pochon CHA University, CHA General Hospital, 605 Yeoksam 1 dong, Kangnam Gu, Seoul 135 081, South Korea
    Gene Expr Patterns 6:277-84. 2006
    ..5. Embryos at E12.5 showed the pronounced expression of Usp22 during the early embryonic development, although its expression was not detectable in the gut, liver and heart...
  18. ncbi request reprint Identification and characterization of murine mHAUSP encoding a deubiquitinating enzyme that regulates the status of p53 ubiquitination
    Soo Kyung Lim
    Cell and Gene Therapy Research Institute, Pochon CHA University, CHA General Hospital, Seoul, Korea
    Int J Oncol 24:357-64. 2004
    ..The overexpression of mHAUSP reduces the amount of ubiquitinated p53, indicating that it functions as a deubiquitinating enzyme for p53...
  19. ncbi request reprint A novel cysteine protease HeLa DUB-1 responsible for cleaving the ubiquitin in human ovarian cancer cells
    Myung Sun Kim
    Graduate School of Life Science and Biotechnology, Pochon CHA University, CHA General Hospital, Seoul 135 081, Korea
    Int J Oncol 25:373-9. 2004
    ..Interestingly, the expression was hardly seen in the brain. Localization study indicates that HeLa DUB-1 proteins are present in both the cytoplasm and nucleus...
  20. ncbi request reprint WD-40 repeat containing rat lethal giant larvae recessive oncogene, but not m-tomosyn, restores the salt sensitivity in Saccharomyces cerevisiae
    Yong Soo Kim
    Cell and Gene Therapy Research Institute, Pochon CHA University, CHA General Hospital, 6 5 Yeoksam 1 Dong, Kangnam Gu, Seoul 135 081, Korea
    Int J Oncol 23:229-33. 2003
    ..Functional analysis showed that the expression of the rgl-1 cDNA, but not m-tomosyn, restored partially salt sensitivity in yeast, indicating that rgl-1 is a homologue of lgl family members...
  21. ncbi request reprint Deubiquitinating enzyme USP36 contains the PEST motif and is polyubiquitinated
    Myung Sun Kim
    Graduate School of Life Science and Biotechnology, Pochon CHA University, CHA General Hospital, Seoul 135 081, Republic of Korea
    Biochem Biophys Res Commun 330:797-804. 2005
    ..Interestingly, structural and immunoprecipitation analyses revealed for the first time that USP36 contains the PEST motif and is polyubiquitinated...
  22. pmc Hyaluronan- and RNA-binding deubiquitinating enzymes of USP17 family members associated with cell viability
    Ju Mi Shin
    Graduate School of Life Science and Biotechnology, Cell and Gene Therapy Research Institute, Pochon CHA University, CHA General Hospital, Seoul 135 081, Korea
    BMC Genomics 7:292. 2006
    ..Deubiquitination, a reversal of ubiquitination, has been recognized as an important regulatory step in the ubiquitin-dependent degradation pathway...
  23. pmc Hyaluronan binding motifs of USP17 and SDS3 exhibit anti-tumor activity
    Suresh Ramakrishna
    Department of Biomedical Science, CHA University, CHA General Hospital, Gyeonggi Do, Republic of Korea
    PLoS ONE 7:e37772. 2012
    ..We wished to investigate whether the HABMs of USP17 were responsible for tumor suppression activity...
  24. ncbi request reprint Functional and expression analyses of mgl-1, a mouse orthologue of lethal giant larvae recessive oncogene
    Yong Soo Kim
    Cell and Gene Therapy Research Institute, Pochon CHA University, CHA General Hospital, Seoul, Korea
    Int J Oncol 23:1515-9. 2003
    ..5 to E18.5 with the strong expression at E10.5. The analysis of spatial expression showed that mgl-1 mRNA is detected in CNS, craniofacial region, eyes, limbs, and the gut...
  25. pmc Stability and function of mammalian lethal giant larvae-1 oncoprotein are regulated by the scaffolding protein RanBPM
    Bharathi Suresh
    Department of Biomedical Science, CHA University, CHA General Hospital, Seoul 135 081, Korea
    J Biol Chem 285:35340-9. 2010
    ..Taken together, our findings reveal that RanBPM plays a novel role in regulating Mgl-1 stability and contributes to its biological function as a tumor suppressor...
  26. ncbi request reprint Single nucleotide polymorphism in exon 17 of the insulin receptor gene is not associated with polycystic ovary syndrome in a Korean population
    Eung Ji Lee
    Graduate School of Life Science and Biotechnology, Cell and Gene Therapy Research Institute, Fertility Medical Center, Pochon CHA University, CHA General Hospital, Kangnam Gu, Seoul 135 081, Korea
    Fertil Steril 86:380-4. 2006
    ..To assess the association between the single nucleotide polymorphism of the insulin receptor (INSR) gene and polycystic ovary syndrome (PCOS) in a Korean population...
  27. ncbi request reprint Complementation of temperature tolerance by rat Rgl-1 recessive oncogene in the absence of Saccharomyces cerevisiae Sop genes
    Yu Kyung Kim
    Graduate School of Life Science and Biotechnology, Pochon CHA University, CHA General Hospital, 605 Yeoksam 1 dong, Kangnam Gu, Seoul 135 081, Korea
    Oncol Rep 12:1105-8. 2004
    ..This indicates that the Rgl-1 cDNA we isolated from the rat brain is highly homologous to Lgl family members and can also substitute the function of Sop proteins for temperature tolerance in Saccharomyces cerevisiae...
  28. ncbi request reprint Genetic variations of follicle stimulating hormone receptor are associated with polycystic ovary syndrome
    Bon Hee Gu
    Department of Biomedical Science, Fertility Center, CHA University, CHA General Hospital, Seoul 135 081, Korea
    Int J Mol Med 26:107-12. 2010
    ..6963, OR=1.08). In haplotype analysis, Ser680Asn and Ala307Thr polymorphisms are not related with PCOS. Consequently, the Ser680Asn polymorphism of FSHR might significantly affect PCOS patients, separately from the Ala307Thr polymorphism...
  29. ncbi request reprint Disruption of protein-protein interaction in the Mgl-1 oncoprotein
    Yong Soo Kim
    Cell and Gene Therapy Research Institute, Graduate School of Life Science and Biotechnology, Pochon CHA University, CHA General Hospital, Seoul 135 081, Korea
    Oncol Rep 16:795-800. 2006
    ..These results indicate that the WD-40 repeat motif is important for cellular viability by regulating temperature-sensitivity and salt tolerance in yeast...
  30. pmc Lys-63-specific deubiquitination of SDS3 by USP17 regulates HDAC activity
    Suresh Ramakrishna
    Department of Biomedical Science, CHA University, CHA General Hospital, Seoul 135 081, Korea
    J Biol Chem 286:10505-14. 2011
    ..These data support the possibility that SDS3, being a substrate of USP17, may play an important role in developing a novel therapeutic means to inhibit specific HDAC activities in cancer...
  31. ncbi request reprint A novel single nucleotide polymorphism of INSR gene for polycystic ovary syndrome
    Eung Ji Lee
    Graduate School of Life Science and Biotechnology, Cell and Gene Therapy Research Institute, Pochon CHA University, CHA General Hospital, Seoul, South Korea
    Fertil Steril 89:1213-20. 2008
    ..To investigate several single nucleotide polymorphisms (SNPs) in the insulin receptor (INSR) gene that have significant associations with pathogenesis of polycystic ovary syndrome (PCOS) in a Korean population...
  32. ncbi request reprint Proteomic analysis of recurrent spontaneous abortion: Identification of an inadequately expressed set of proteins in human follicular fluid
    Yong Soo Kim
    Cell and Gene Therapy Research Institute, Pochon CHA University, CHA General Hospital, Seoul, Korea
    Proteomics 6:3445-54. 2006
    ..Taken all together, it is likely that coagulation factors (fibrinogen gamma and antithrombin) play an important role in maintaining the normal pregnancy...
  33. ncbi request reprint HAUSP, a deubiquitinating enzyme for p53, is polyubiquitinated, polyneddylated, and dimerized
    Hye Jin Lee
    Graduate School of Life Science and Biotechnology, Cell and Gene Therapy Research Institute, Pochon CHA University, CHA General Hospital, 605 Yeoksam 1 dong, Kangnam Gu, Seoul 135 081, Korea
    FEBS Lett 579:4867-72. 2005
    ..Transfection of rHAUSP into RGC-Lac-Z cell line with the integrated p53 response element revealed that rHAUSP contributed to p53 stabilization, and a rHAUSP (C224S) mutant contributed to p53 destabilization in a dose-dependent manner...
  34. doi request reprint Protein stability of mitochondrial superoxide dismutase SOD2 is regulated by USP36
    Myung Sun Kim
    Department of Biomedical Science, CHA General Hospital, CHA University, Seoul, Republic of Korea
    J Cell Biochem 112:498-508. 2011
    ..Finally, USP36 was shown to be a specific deubiquitinating enzyme that reduces the ubiquitination level of SOD2 and was involved in SOD2 protein stability by extending its half-life...
  35. doi request reprint Glutamate-ammonia ligase and reduction of G0 population in PANC-1 cells
    Jong Ho Choi
    College of Medicine, CHA University, CHA General Hospital, Gyeonggi Do 463 840, Republic of Korea
    J Cell Biochem 114:303-13. 2013
    ..In addition, GLUL-overexpressing cells had high activation levels of AKT, ERK1/2, JNK, PCNA, c-FOS, and P70S6K in PANC-1 cells. Taken together, these results suggest that GLUL contributes to pancreatic regeneration...
  36. ncbi request reprint The expression of Usp42 during embryogenesis and spermatogenesis in mouse
    Yu Kyung Kim
    Cell and Gene Therapy Research Institute, Graduate School of Life Science and Biotechnology, Pochon CHA University, CHA General Hospital, Seoul 135 081, Republic of Korea
    Gene Expr Patterns 7:143-8. 2007
    ..Taken all together, it is suggested that Usp42 is one of typical deubiquitinating enzymes, which may play an important role in mouse embryogenesis and spermatogenesis...
  37. doi request reprint K48- and K63-linked polyubiquitination of deubiquitinating enzyme USP44
    Bharathi Suresh
    CHA Stem Cell Institute, College of Medicine, CHA University, CHA General Hospital, Seoul 135081, South Korea
    Cell Biol Int 34:799-808. 2010
    ..Furthermore, we raised a polyclonal antibody against USP44 and checked its endogenous protein expression in different cell lines. A localization study of USP44 showed its predominant expression in the nucleus...
  38. ncbi request reprint 14-3-3 gamma is stimulated by IL-3 and promotes cell proliferation
    Brijesh S Ajjappala
    Graduate School of Life Science and Biotechnology, Cell and Gene Therapy Research Institute, Pochon CHA University, CHA General Hospital, Seoul, Korea
    J Immunol 182:1050-60. 2009
    ..These results indicate that deregulated expression of 14-3-3gamma may contribute to malignant transformation, possibly providing a new target for therapeutic intervention in hematopoietic neoplasms...
  39. ncbi request reprint The rgl-1 is a legitimate homologue of lethal giant larvae recessive oncogene in rat
    Yong Soo Kim
    College of Medicine, Pochon CHA University, CHA General Hospital, Seoul, Korea
    Int J Oncol 20:1219-25. 2002
    ..Taken together, these results indicate that rgl-1, not tomosyn, is the legitimate homologue of lgl gene...
  40. ncbi request reprint Expression of angiogenesis- and apoptosis-related genes in chorionic villi derived from recurrent pregnancy loss patients
    Hee Kyung Choi
    College of Medicine, Pochon CHA University, and Cell and Gene Therapy Research Institute, Seoul, Korea
    Mol Reprod Dev 66:24-31. 2003
    ..Taken all together, it is likely that the lower expression of angiogenesis-related genes and the excessive expression of apoptosis-related genes are associated with RPL...
  41. ncbi request reprint Murine Asb-17 expression during mouse testis development and spermatogenesis
    Kye Seong Kim
    Cell and Gene Therapy Research Institute, Graduate School of Life Science and Biotechnology, Pochon CHA University, CHA General Hospital, Seoul, Korea
    Zygote 12:151-6. 2004
    ..Both northern blot and RT-PCR analyses suggest that mASB-17 may play essential roles in testis development and spermatogenesis...
  42. doi request reprint Apolipoprotein A-IV as a novel gene associated with polycystic ovary syndrome
    Yong Soo Kim
    Department of Biomedical Science, Fertility Center, CHA University, CHA General Hospital, Seoul, Republic of Korea
    Int J Mol Med 31:707-16. 2013
    ..These results facilitate the understanding of the molecular mechanisms of PCOS and provide candidate biomarkers for the development of diagnostic and therapeutic tools...
  43. doi request reprint LCP1 up-regulated by partial pancreatectomy supports cell proliferation and differentiation
    Jong Ho Choi
    College of Medicine, CHA University, Bundang CHA Hospital, 502 Yatap Dong, Bundang gu, Seongnam si, Gyeonggi Do 463 840, Republic of Korea
    Mol Biosyst 7:3104-11. 2011
    ..These data indicate that the LCP1 may play a critical role in the pancreas regeneration...
  44. doi request reprint DUB-1, a fate determinant of dynein heavy chain in B-lymphocytes, is regulated by the ubiquitin-proteasome pathway
    Min Young Lee
    Cell and Gene Therapy Research Institute, Graduate School of Life Science and Biotechnology, Pochon CHA University, CHA General Hospital, Seoul, Republic of Korea
    J Cell Biochem 105:1420-9. 2008
    ..In addition, structural and immunoprecipitation analyses revealed that DUB-1 contains a putative PEST motif and is polyubiquitinated, indicating that DUB-1 is also regulated by the ubiquitin-proteasome pathway...
  45. pmc Ell3 stabilizes p53 following CDDP treatment via its effects on ubiquitin-dependent and -independent proteasomal degradation pathways in breast cancer cells
    Hee Jin Ahn
    Department of Biomedical Science, College of Life Science and CHA Stem Cell Institute, CHA University, Seoul, Korea
    Oncotarget 6:44523-37. 2015
    ..These findings suggest that the ERK1/2 pathway can be targeted in the rational development of therapies to induce chemosensitization of breast cancer cells. ..
  46. ncbi request reprint The WD-40 repeat motif of Lgl tumor suppressor proteins associated with salt tolerance and temperature sensitivity
    Yu Kyung Kim
    Cell and Gene Therapy Research Institute, Graduate School of Life Science and Biotechnology, Pochon CHA University, CHA General Hospital, Seoul 135 081, Republic of Korea
    Biochem Biophys Res Commun 331:922-8. 2005
    ..These results shed light on the important regulation of cytoskeletal complex for cellular polarity within eukaryotic cells...
  47. doi request reprint PEST motif sequence regulating human NANOG for proteasomal degradation
    Suresh Ramakrishna
    Department of Biomedical Science, CHA General Hospital, CHA University, Seoul, Korea
    Stem Cells Dev 20:1511-9. 2011
    ..Deletion of the PEST motif reduced ubiquitination of NANOG, leading to NANOG stabilization. Collectively, these results indicate that the expression level, stability, and activity of NANOG are modulated by post-translational mechanisms...
  48. pmc Ubiquitin specific protease 19 involved in transcriptional repression of retinoic acid receptor by stabilizing CORO2A
    Key Hwan Lim
    Department of Biomedical Science, Bundang CHA Hospital, Bundang gu, Seongnam si, Gyeonggi do 463 400, Republic of Korea
    Oncotarget 7:34759-72. 2016
    ....
  49. doi request reprint The role of deubiquitinating enzymes in apoptosis
    Suresh Ramakrishna
    Department of Biomedical Science, CHA General Hospital, CHA University, 606 16 Yeoksam 1 dong, Gangnam Gu, Seoul, 135 081, Republic of Korea
    Cell Mol Life Sci 68:15-26. 2011
    ..This review discusses the role of a few ubiquitin-specific DUBs that are involved in either promoting or suppressing the process of apoptosis...
  50. doi request reprint Polyclonal and monoclonal antibodies specific for USP17, a proapoptotic deubiquitinating enzyme
    Suresh Ramakrishna
    Department of Biomedical Science, CHA University, CHA General Hospital, Seoul, Korea
    Hybridoma (Larchmt) 29:311-9. 2010
    ..These antibodies of USP17 will be useful as tools to investigate the mechanism of hyaluronan-mediated tumor suppression and also to screen interacting oncogenic substrates by immunoprecipitation assay...
  51. doi request reprint Critical lysine residues of Klf4 required for protein stabilization and degradation
    Key Hwan Lim
    Department of Biomedical Science, CHA Stem Cell Institute, CHA University, Bundang CHA General Hospital, Gyeonggi Do 463 840, Republic of Korea
    Biochem Biophys Res Commun 443:1206-10. 2014
    ..These results suggest that Klf4 undergoes proteasomal degradation and that these lysine residues are critical for Klf4 ubiquitination. ..
  52. doi request reprint Relationship between leptin receptor and polycystic ovary syndrome
    Lan Li
    Department of Biomedical Science, CHA University, Bundang CHA Hospital, 502 Yatap Dong, Bundang gu, Seongnam si, Gyeonggi Do 463 840, Republic of Korea
    Gene 527:71-4. 2013
    ..0001, OR=0.446, 95% confidence interval). Moreover, genotype combination and haplotype analyses indicate that Gln223Arg and Pro1019Pro polymorphisms of LEPR are significantly associated with the risk of PCOS. ..
  53. ncbi request reprint Association study between single nucleotide polymorphisms in the VEGF gene and polycystic ovary syndrome
    Eung Ji Lee
    Graduate School of Life Science and Biotechnology, Cell and Gene Therapy Research Institute, Pochon CHA University, CHA General Hospital, Seoul, Korea
    Fertil Steril 89:1751-9. 2008
    ..To investigate single nucleotide polymorphisms (SNPs) in vascular endothelial growth factor (VEGF) gene that have significant associations with the pathogenesis of polycystic ovary syndrome (PCOS) in a Korean population...
  54. doi request reprint Association between INS-VNTR polymorphism and polycystic ovary syndrome in a Korean population
    Ji Hyun Yun
    Department of Biomedical Science, CHA Stem Cell Institute, CHA University, Bundang CHA Hospital, Gyeonggi Do, Korea
    Gynecol Endocrinol 28:525-8. 2012
    ..Our present data demonstrate that INS-VNTR polymorphism is not related with PCOS in Korean women. Thus, it is suggested that INS-VNTR polymorphism is not a key factor in the etiology and the pathogenesis of PCOS in a Korean population...
  55. doi request reprint ITI-H4, as a biomarker in the serum of recurrent pregnancy loss (RPL) patients
    Myung Sun Kim
    Department of Biomedical Science, CHA University, CHA General Hospital, 606 16 Yeoksam 1 dong, Gangnam Gu, Seoul 135 081, Korea
    Mol Biosyst 7:1430-40. 2011
    ..These findings suggest that ITI-H4 expression may be used as a biomarker, which could facilitate the development of novel diagnostic and therapeutic tools...
  56. doi request reprint Molecular mechanisms and functions of cytokine-inducible deubiquitinating enzymes
    Key Hwan Lim
    Department of Biomedical Science, CHA University, Bundang CHA General Hospital, Gyeonggi Do 463 840, Republic of Korea
    Cytokine Growth Factor Rev 24:427-31. 2013
    ..Finally, we emphasize the importance of small molecules for cytokine-inducible DUBs for developing promising drug therapeutics for immune-related disorders. ..
  57. doi request reprint Association study of +45G15G(T/G) and +276(G/T) polymorphisms in the adiponectin gene in patients with polycystic ovary syndrome
    Lan Li
    Department of Biomedical Science, CHA University, CHA General Hospital, Seoul, Korea
    Int J Mol Med 27:283-7. 2011
    ..0126, OR=0.60, 95% confidence interval). These results indicate that the SNP of +276(G/T) is strongly associated with PCOS. However, the +45(T/G) SNP is not associated with PCOS...
  58. doi request reprint Isolation of genes involved in pancreas regeneration by subtractive hybridization
    Jong Ho Choi
    College of Medicine, CHA University, CHA General Hospital, Seoul 135 081, Korea
    Biol Chem 391:1019-29. 2010
    ..2, PAX4 and PAX6 are up-regulated and somatostatin is down-regulated. Thus, we believe that Glul, Lgmn and Reg3a can serve as novel targets in diabetes mellitus genetic therapy...
  59. doi request reprint Association study between the -866G/A polymorphism in the promoter of uncoupling protein-2 gene and polycystic ovary syndrome
    Jun Hyun Kim
    Department of Biomedical Science, CHA University, CHA General Hospital, Gangnam Gu, Seoul 135 081, Republic of Korea
    Mol Med Rep 4:747-51. 2011
    ..7168, OR=1.07, 95% CI). The present study showed that -866G/A, a UCP2 gene polymorphism, is not associated with the pathogenesis of PCOS...
  60. pmc Human umbilical cord blood mononuclear cells and chorionic plate-derived mesenchymal stem cells promote axon survival in a rat model of optic nerve crush injury
    Sokjoong Chung
    Department of Ophthalmology, CHA Bundang Medical Center, CHA University, Seongnam si, Gyeonggi Do, Republic of Korea
    Int J Mol Med 37:1170-80. 2016
    ....
  61. pmc HAUSP-nucleolin interaction is regulated by p53-Mdm2 complex in response to DNA damage response
    Key Hwan Lim
    Department of Biomedical Science, CHA University, Bundang CHA General Hospital, Gyeonggi do 463 400, Republic of Korea
    Sci Rep 5:12793. 2015
    ..Taken together, this study reveals a new component of the HAUSP-p53-Mdm2 complex that governs dynamic cellular responses to DNA damage. ..
  62. pmc Deubiquitinating enzyme USP37 regulating oncogenic function of 14-3-3γ
    Jin Ock Kim
    Department of Biomedical Science, CHA University, Bundang CHA Hospital, Gyeonggi do 463 400, Republic of Korea
    Oncotarget 6:36551-76. 2015
    ....
  63. doi request reprint 54G/C polymorphism of SREBF-1 gene is associated with polycystic ovary syndrome
    Lan Li
    Department of Biomedical Science, CHA University, Bundang CHA Hospital, Seongnam 463 840, Gyeonggi Do, Republic of Korea
    Eur J Obstet Gynecol Reprod Biol 188:95-9. 2015
    ..Among these, polycystic ovary syndrome (PCOS) is known as a common metabolic-endocrine disorder of women in reproductive ages...
  64. ncbi request reprint Association study for single nucleotide polymorphisms in the CYP17A1 gene and polycystic ovary syndrome
    Jung Mi Park
    Graduate School of Life Science and Biotechnology, Cell and Gene Therapy Research Institute, Pochon CHA University, CHA General Hospital, Seoul, Korea
    Int J Mol Med 22:249-54. 2008
    ..The frequency of seven SNPs had no significant association with PCOS. However, one haplotype (ht3) had a p-value of p=0.001, suggesting that it may be associated with the pathogenesis of PCOS in a Korean population...
  65. ncbi request reprint Deubiquitinating enzymes as therapeutic targets in cancer
    Key Hwan Lim
    Department of Biomedical Science, CHA University, CHA General Hospital, 502 Yatap Dong, Bundang gu, Seongnam si, Gyeonggi Do 463 840, Republic of Korea
    Curr Pharm Des 19:4039-52. 2013
    ..Here, we review structures, substrates, and small inhibitor molecules of DUBs identified up to date, providing a clear rationale for the development of novel small inhibitor molecules of DUBs for cancer...
  66. ncbi request reprint Quantification of mitochondrial DNA using real-time polymerase chain reaction in patients with premature ovarian failure
    Kwang Yul Cha
    Department of Obstetrics and Gynecology, CHA General Hospital, Pochon CHA University, Seoul, Korea
    Fertil Steril 84:1712-8. 2005
    ..To quantify mitochondrial DNA using real-time PCR in women with premature ovarian failure (POF) and a control group...
  67. pmc Generation of dopamine neurons with improved cell survival and phenotype maintenance using a degradation-resistant nurr1 mutant
    A Young Jo
    Department of Biochemistry and Molecular Biology, College of Medicine, Hanyang University, Seoul, Korea
    Stem Cells 27:2238-46. 2009
    ..The sustained Nurr1 expression endowed the Nurr1(Akt)-induced DA neurons with resistance to toxic stimuli, enhanced survival, and sustained DA phenotypes in vitro and in vivo after transplantation...
  68. doi request reprint Diverse roles of the scaffolding protein RanBPM
    Bharathi Suresh
    Department of Biomedical Science, CHA University, CHA General Hospital, Seoul 135 081, Republic of Korea
    Drug Discov Today 17:379-87. 2012
    ..Also, we have categorized the role of RanBPM into four divisions: RanBPM as a modulator/protein stabilizer, regulator of transcription activity, cell cycle and neurological functions...
  69. pmc The promoter -1031(T/C) polymorphism in tumor necrosis factor-alpha associated with polycystic ovary syndrome
    Ji Hyun Yun
    Department of Biomedical Science, CHA University, Bundang CHA General Hospital, Gyeonggi Do, Republic of Korea
    Reprod Biol Endocrinol 9:131. 2011
    ..Here, we performed a comparative study of -1031(T/C) polymorphism of TNF-alpha gene with PCOS in a Korean population...
  70. ncbi request reprint HAUSP as a therapeutic target for hematopoietic tumors (review)
    Kang Woo Cheon
    Graduate School of Life Science and Biotechnology, Cell and Gene Therapy Research Institute, Pochon CHA University, CHA General Hospital, Seoul 135 081, Korea
    Int J Oncol 28:1209-15. 2006
    ....
  71. doi request reprint Protein chip analysis of pluripotency-associated proteins in NIH3T3 fibroblast
    Brijesh S Ajjappala
    Department of Biomedical Sciences, CHA Stem Cell Institute, CHA University, CHA General Hospital, Seoul 135 081, Korea
    Proteomics 9:3968-78. 2009
    ..Our results signify that the combinatorial signaling protein-array using biomolecular approach may possibly provide us with a new tool to understand cellular homeostasis...
  72. ncbi request reprint A single nucleotide polymorphism in exon 7 of sorbin and SH3-domain-containing-1 (SORBS1) in Korean PCOS patients
    Jung Mi Park
    Graduate School of Life Science and Biotechnology, Cell and Gene Therapy Research Institute, Pochon CHA University, CHA General Hospital, Seoul 135 081, Korea
    Mol Med Report 1:93-7. 2008
    ..A statistically significant relationship was found between the SNP in exon 7 of the SORBS1 gene and PCOS in a Korean population group...
  73. ncbi request reprint Enhanced cellular delivery and transfection efficiency of plasmid DNA using positively charged biocompatible colloidal gold nanoparticles
    Sang Myoung Noh
    Graduate School of Life Science and Biotechnology, Pochon CHA University, Seoul, Korea
    Biochim Biophys Acta 1770:747-52. 2007
    ..Collectively, the results of this study suggest that the PGN/DNA complexes may harbor the potential for development into efficient and safe gene delivery vehicles...
  74. doi request reprint Pegylated poly-l-arginine derivatives of chitosan for effective delivery of siRNA
    Sang Myoung Noh
    College of Pharmacy, Seoul National University, Sinlim Dong, Gwanak Gu, Seoul, South Korea
    J Control Release 145:159-64. 2010
    ..These results indicate that pegylated CS-PLR might be useful for in vivo delivery of therapeutic siRNAs...
  75. doi request reprint Polyclonal and monoclonal antibodies specific for ubiquitin-specific protease 20
    Jang Joon Park
    Department of Biomedical Science, CHA University, CHA General Hospital, Seongnam, Republic of Korea
    Monoclon Antib Immunodiagn Immunother 32:193-9. 2013
    ..It is feasible that USP20 antibodies can be useful to investigate USP20-related cellular mechanisms and to find novel substrates of USP20...
  76. ncbi request reprint Differentially up-regulated genes in proliferating porcine neonatal pancreas cells caused by epidermal growth factor
    Sung Yoon Jeon
    Department of Endocrinology and Metabolism, Immunology and Cell Biology Core Laboratory, The Catholic University of Korea, Seoul, Korea
    J Cell Biochem 91:354-64. 2004
    ..We confirmed the up-regulation of these genes by Northern blot and semi-quantitative RT-PCR at various time points. The present findings opened new targets for the research on the mechanisms of pancreatic duct cell proliferation by EGF...
  77. ncbi request reprint Differential expression profiling of genes in a complete hydatidiform mole using cDNA microarray analysis
    Seung Jo Kim
    Comprehensive Gynecologic Cancer Center, CHA General Hospital, Kyonggi Do, South Korea
    Gynecol Oncol 103:654-60. 2006
    ....
  78. ncbi request reprint DUB-3, a cytokine-inducible deubiquitinating enzyme that blocks proliferation
    James F Burrows
    Department of Microbiology and Immunology, Queen s University, Belfast, Northern Ireland
    J Biol Chem 279:13993-4000. 2004
    ..These findings suggest that human DUB-3, like the murine DUB family members, is transiently induced in response to cytokines and can, when constitutively expressed, block growth factor-dependent proliferation...
  79. pmc Pepper EST database: comprehensive in silico tool for analyzing the chili pepper (Capsicum annuum) transcriptome
    Hyun Jin Kim
    Omics Integration Research Center, KRIBB, Yuseong Gu, Daejeon, Korea
    BMC Plant Biol 8:101. 2008
    ..Therefore, a chili pepper EST database was designed and constructed to enable comprehensive analysis of chili pepper gene expression in response to biotic and abiotic stresses...
  80. ncbi request reprint Protein kinase A phosphorylates and regulates dimerization of 14-3-3 epsilon
    Young Mi Gu
    College of Pharmacy, Chonnam National University, Yongbong dong 300, Buk Gu, Gwangju 500757, Republic of Korea
    FEBS Lett 580:305-10. 2006
    ..Therefore, our results suggest that PKA is a new member of protein kinases that can phosphorylate and impair the function of 14-3-3...
  81. ncbi request reprint Long oligonucleotide microarrays in wheat: evaluation of hybridization signal amplification and an oligonucleotide-design computer script
    Daniel Z Skinner
    USDA ARS and Crop and Soil Science Department, Washington State University, 209 Johnson Hall, Pullman, WA 99164, USA
    Funct Integr Genomics 5:70-9. 2005
    ....
  82. ncbi request reprint Trophoblast apoptosis is increased in women with evidence of TH1 immunity
    Jiae Lee
    Laboratory of Reproductive Medicine, Center for Recurrent Miscarriage and Infertility, Creation and Love Women s Hospital, Kwangju Institute of Science and Technology K JIST, 13 21 Gwangchun Dong, Seo Gu, Gwangju 502 210, Korea
    Fertil Steril 83:1047-9. 2005
    ..Apoptosis was significantly increased in trophoblast cells cultured with the supernatant of PBMCs from women with evidence of T(H)1 immunity to trophoblast stimulation...
  83. ncbi request reprint Capsicum annuum CCR4-associated factor CaCAF1 is necessary for plant development and defence response
    Sujon Sarowar
    Plant Genome Research Center, KRIBB, Daejeon, Korea
    Plant J 51:792-802. 2007
    ..vesicatoria. Our results suggest roles for plant CAF1 in normal growth and development, as well as in defence against pathogens...
  84. ncbi request reprint Differential expression of manganese superoxide dismutase sequence variants in near isogenic lines of wheat during cold acclimation
    Kwang Hyun Baek
    Department of Crop and Soil Sciences, 210 Johnson Hall, Washington State University, Pullman, WA 99164 6420, USA
    Plant Cell Rep 25:223-30. 2006
    ..Diploid wheat-related species also carried sequence variants of MnSOD, with differing levels of expression, suggesting diversification of the MnSOD gene family occurred prior to the polyploidization events of hexaploid wheat...
  85. ncbi request reprint Differential mRNA stability to endogenous ribonucleases of the coding region and 3' untranslated regions of wheat (Triticum aestivum L.) manganese superoxide dismutase genes
    Kwang Hyun Baek
    Department of Crop and Soil Sciences, Washington State University, WA 99164 6420, USA
    Plant Cell Rep 25:133-9. 2006
    ..Further investigation revealed the coding region seemed to have specific sites for degradation, indicating a possibility of increasing MnSOD expression by the degradation site alteration...