Seon Young Nam

Summary

Country: Korea

Publications

  1. pmc Phosphorylation of CLK2 at serine 34 and threonine 127 by AKT controls cell survival after ionizing radiation
    Seon Young Nam
    Radiation Health Research Institute, Korea Hydro and Nuclear Power Co, Ltd, Seoul 132 703, Korea
    J Biol Chem 285:31157-63. 2010
  2. pmc A synergistic interaction between transcription factors nuclear factor-κB and signal transducers and activators of transcription 3 promotes gastric cancer cell migration and invasion
    Jiyeon Yoon
    Department of Anatomy, Seoul National University College of Medicine, Seoul, 110 799, South Korea
    BMC Gastroenterol 13:29. 2013
  3. ncbi Low-dose radiation stimulates the proliferation of normal human lung fibroblasts via a transient activation of Raf and Akt
    Cha Soon Kim
    Radiation Health Research Institute, Korea Hydro and Nuclear Power Co, Ltd, Seoul 132 703, Korea
    Mol Cells 24:424-30. 2007
  4. doi Chronic low-dose radiation inhibits the cells death by cytotoxic high-dose radiation increasing the level of AKT and acinus proteins via NF-κB activation
    Hyung Sun Park
    Radiation Health Research Institute, Korea Hydro and Nuclear Power Co, Ltd, Seoul, Korea
    Int J Radiat Biol 89:371-7. 2013
  5. doi TOPORS modulates H2AX discriminating genotoxic stresses
    Ki Moon Seong
    Division of Radiation Effect Research, Radiation Health Research Institute, Korea Hydro and Nuclear Power Co, Ltd, 132 703, Seoul, Korea
    J Biochem Mol Toxicol 26:429-38. 2012
  6. doi A critical role for AKT activation in protecting cells from ionizing radiation-induced apoptosis and the regulation of acinus gene expression
    Hyung Sun Park
    Radiation Health Research Institute, Korea Hydro and Nuclear Power Co Ltd, Seoul 132 703, Republic of Korea
    Eur J Cell Biol 88:563-75. 2009
  7. ncbi Low-dose radiation induces Drosophila innate immunity through Toll pathway activation
    Ki Moon Seong
    Division of Radiation Effect Research, Radiation Health Research Institute, Korea Hydro and Nuclear Power Co, Ltd, Seoul, Korea 132 703
    J Radiat Res 53:242-9. 2012
  8. doi Ret finger protein 2 enhances ionizing radiation-induced apoptosis via degradation of AKT and MDM2
    Hae Mi Joo
    Radiation Health Research Institute, Korea Hydro and Nuclear Power Co, Ltd, Seoul 132 703, Republic of Korea
    Eur J Cell Biol 90:420-31. 2011
  9. pmc The effects of low-dose ionizing radiation in the activated rat basophilic leukemia (RBL-2H3) mast cells
    Hae Mi Joo
    Radiation Effect Research Team, Radiation Health Research Institute, Korea Hydro and Nuclear Power Co, Ltd, Seoul 132 703, Korea
    J Biol Chem 287:27789-95. 2012
  10. doi Genome-wide analysis of low-dose irradiated male Drosophila melanogaster with extended longevity
    Ki Moon Seong
    Division of Radiation Effect Research, Radiation Health Research Institute, Korea Hydro and Nuclear Power Co, Ltd, Dobong gu, Seoul, Korea
    Biogerontology 12:93-107. 2011

Collaborators

  • Kyung Jin Min
  • Jie Young Song
  • Woong Yang Park
  • Kyung Mi Lee
  • Ju Han Kim
  • Cha Soon Kim
  • Kwang Hee Yang
  • Young Woo Jin
  • Ki Moon Seong
  • Hae Mi Joo
  • Hyung Sun Park
  • Sungkwan An
  • Hee Sun Kim
  • Meeseon Jeong
  • Chong Soon Kim
  • Byung Sub Lee
  • In Kyung Lee
  • Jiyeon Yoon
  • Young Khi Lim
  • Suk Chul Shin
  • Su Jae Lee
  • Su Jin Kang
  • Ga Eun You
  • Sang Yeun Han
  • Dong Hoon Shin
  • Mee Soo Chang
  • Woo Ho Kim
  • Hye Seung Lee
  • Sung Jin Cho
  • Min A Kim
  • In Chan Hwang
  • Jinju Park
  • Byung Lan Lee
  • Young San Ko
  • Joong Jean Park
  • Sun Won Seo
  • Kwanghee Kim
  • Yu Mi Kang
  • Ha Yeon Jeon
  • Seon Ah Lim
  • Jae Boon Jeong
  • Sung Kwan Ahn
  • Yunha Yun
  • Young Ji Na
  • Seung Up Kim
  • Young Ju Lee
  • Meeseon Jung
  • Keun Young Yoo
  • Heesun Kim
  • Woo Kyung Kim
  • Jung Eun Lee

Detail Information

Publications16

  1. pmc Phosphorylation of CLK2 at serine 34 and threonine 127 by AKT controls cell survival after ionizing radiation
    Seon Young Nam
    Radiation Health Research Institute, Korea Hydro and Nuclear Power Co, Ltd, Seoul 132 703, Korea
    J Biol Chem 285:31157-63. 2010
    ..Our results suggest that AKT activation controls cell survival to ionizing radiation by phosphorylating CLK2, revealing an important regulatory mechanism required for promoting cell survival...
  2. pmc A synergistic interaction between transcription factors nuclear factor-κB and signal transducers and activators of transcription 3 promotes gastric cancer cell migration and invasion
    Jiyeon Yoon
    Department of Anatomy, Seoul National University College of Medicine, Seoul, 110 799, South Korea
    BMC Gastroenterol 13:29. 2013
    ..We investigated the role of the interaction between NF-κB and signal transducers and activators of transcription 3 (STAT3) in controlling metastatic potential of gastric cancer cells...
  3. ncbi Low-dose radiation stimulates the proliferation of normal human lung fibroblasts via a transient activation of Raf and Akt
    Cha Soon Kim
    Radiation Health Research Institute, Korea Hydro and Nuclear Power Co, Ltd, Seoul 132 703, Korea
    Mol Cells 24:424-30. 2007
    ..These results suggest that 0.05 Gy of ionizing radiation stimulates cell proliferation through the transient activation of Raf and Akt in CCD-18 Lu cells...
  4. doi Chronic low-dose radiation inhibits the cells death by cytotoxic high-dose radiation increasing the level of AKT and acinus proteins via NF-κB activation
    Hyung Sun Park
    Radiation Health Research Institute, Korea Hydro and Nuclear Power Co, Ltd, Seoul, Korea
    Int J Radiat Biol 89:371-7. 2013
    ..This study explored the effects of low-dose and low-dose-rate irradiation in human lung fibroblast CCD-18Lu cells and examined the role of AKT (protein kinase B, PKB) in cellular responses...
  5. doi TOPORS modulates H2AX discriminating genotoxic stresses
    Ki Moon Seong
    Division of Radiation Effect Research, Radiation Health Research Institute, Korea Hydro and Nuclear Power Co, Ltd, 132 703, Seoul, Korea
    J Biochem Mol Toxicol 26:429-38. 2012
    ..Therefore, these biochemical data suggest that TOPORS plays a key role in the turnover of H2AX protein, discriminating the type of DNA damaging stress...
  6. doi A critical role for AKT activation in protecting cells from ionizing radiation-induced apoptosis and the regulation of acinus gene expression
    Hyung Sun Park
    Radiation Health Research Institute, Korea Hydro and Nuclear Power Co Ltd, Seoul 132 703, Republic of Korea
    Eur J Cell Biol 88:563-75. 2009
    ..The AKT/NF-kappaB/acinus pathway functions as one of the important regulatory mechanisms required for modulating ionizing radiation sensitivity...
  7. ncbi Low-dose radiation induces Drosophila innate immunity through Toll pathway activation
    Ki Moon Seong
    Division of Radiation Effect Research, Radiation Health Research Institute, Korea Hydro and Nuclear Power Co, Ltd, Seoul, Korea 132 703
    J Radiat Res 53:242-9. 2012
    ..These results indicate that innate immunity is activated after low-dose irradiation through Toll signaling pathway in Drosophila...
  8. doi Ret finger protein 2 enhances ionizing radiation-induced apoptosis via degradation of AKT and MDM2
    Hae Mi Joo
    Radiation Health Research Institute, Korea Hydro and Nuclear Power Co, Ltd, Seoul 132 703, Republic of Korea
    Eur J Cell Biol 90:420-31. 2011
    ..Thus, these data suggest that irradiation causes RFP2 overexpression, which enhances ionizing radiation-induced apoptosis by increasing p53 stability and decreasing AKT kinase activity through MDM2 and AKT degradation...
  9. pmc The effects of low-dose ionizing radiation in the activated rat basophilic leukemia (RBL-2H3) mast cells
    Hae Mi Joo
    Radiation Effect Research Team, Radiation Health Research Institute, Korea Hydro and Nuclear Power Co, Ltd, Seoul 132 703, Korea
    J Biol Chem 287:27789-95. 2012
    ..01 Gy). These results were due to the suppression of FcεRI expression by the low-dose ionizing radiation. Therefore, low-dose ionizing radiation (0.01 Gy) may function as a novel inhibitor of mast cell activation...
  10. doi Genome-wide analysis of low-dose irradiated male Drosophila melanogaster with extended longevity
    Ki Moon Seong
    Division of Radiation Effect Research, Radiation Health Research Institute, Korea Hydro and Nuclear Power Co, Ltd, Dobong gu, Seoul, Korea
    Biogerontology 12:93-107. 2011
    ..In addition, this study also suggests a mechanism by which low-dose radiation extends longevity...
  11. doi Differential expression of immune-associated cancer regulatory genes in low- versus high-dose-rate irradiated AKR/J mice
    Suk Chul Shin
    Radiation Health Research Institute, Korea Hydro and Nuclear Power Co, Ltd, Ssangmun dong, Dobong gu, Seoul, Republic of Korea
    Genomics 97:358-63. 2011
    ..Therefore, our data delineate common and distinct immune-associated pathways downstream of low- versus high-dose-rate irradiation in the process of cancer progression in AKR/J mice...
  12. pmc Chronic low-dose γ-irradiation of Drosophila melanogaster larvae induces gene expression changes and enhances locomotive behavior
    Cha Soon Kim
    Low dose Radiation Research Team, Radiation Health Institute, Korea Hydro and Nuclear Power Co Ltd, Seoul 132 703, Korea
    J Radiat Res 56:475-84. 2015
    ..These data suggest that LDR stimulates locomotion-related genes, and these genes can be used as potential markers for LDR. ..
  13. pmc The Inhibitory Effects of Low-Dose Ionizing Radiation in IgE-Mediated Allergic Responses
    Hae Mi Joo
    Low dose Radiation Research Team, Radiation Health Institute, Korea Hydro and Nuclear Power Co, Ltd, Seoul, Korea
    PLoS ONE 10:e0136394. 2015
    ..These results indicate that ionizing radiation inhibits both mast cell-mediated immediate- and delayed-type allergic reactions in vivo and in vitro. ..
  14. doi Role of AKT and ERK pathways in controlling sensitivity to ionizing radiation and adaptive response induced by low-dose radiation in human immune cells
    Hyung Sun Park
    Low dose Radiation Research Team, Radiation Health Institute, Korea Hydro and Nuclear Power Co, Ltd, Seoul 01450, Republic of Korea
    Eur J Cell Biol 94:653-60. 2015
    ....
  15. ncbi Comprehensive analysis of time- and dose-dependent patterns of gene expression in a human mesenchymal stem cell line exposed to low-dose ionizing radiation
    Young Woo Jin
    Division of Radiation Effect Research, Radiation Health Research Institute of KHNP, Seoul 132 703, Korea
    Oncol Rep 19:135-44. 2008
    ..We further characterized the gene expression patterns that could be implicated in the molecular mechanism of the cellular responses to low and very low-dose irradiation...
  16. ncbi Low-dose of ionizing radiation enhances cell proliferation via transient ERK1/2 and p38 activation in normal human lung fibroblasts
    Cha Soon Kim
    Radiation Health Research Institute, Korea Hydro and Nuclear Power Co, Ltd, Seoul, Republic of Korea
    J Radiat Res 48:407-15. 2007
    ..05 Gy of ionizing radiation. These results suggest that 0.05 Gy of ionizing radiation enhances cell proliferation through the activation of ERK1/2 and p38 in normal human lung fibroblasts...