Myung Ae Bae

Summary

Affiliation: Korea Research Institute of Chemical Technology
Country: Korea

Publications

  1. pmc Prominent bone loss mediated by RANKL and IL-17 produced by CD4+ T cells in TallyHo/JngJ mice
    Hee Yeon Won
    Division of Life and Pharmaceutical Sciences, College of Pharmacy, Center for Cell Signaling and Drug Discovery Research, Ewha Womans University, Seoul, Korea
    PLoS ONE 6:e18168. 2011
  2. pmc Selective inhibition of activated stellate cells and protection from carbon tetrachloride-induced liver injury in rats by a new PPARgamma agonist KR62776
    Myung Ae Bae
    Drug Discovery Platform Technology Team, Medicinal Science Division, Korea Research Institute of Chemical Technology, Daejon, 305 600, Korea
    Arch Pharm Res 33:433-42. 2010
  3. doi request reprint Determination of PF-04620110, a novel inhibitor of diacylglycerol acyltransferase-1, in rat plasma using liquid chromatography-tandem mass spectrometry and its application in pharmacokinetic studies
    Kyeong Ryoon Lee
    Drug Discovery Platform Technology Team, Korea Research Institute of Chemical Technology, Daejon, 305 343, Republic of Korea
    Biomed Chromatogr 27:846-52. 2013
  4. doi request reprint Determination of 2-aryl-7(3',4'-dialkoxyphenyl)-pyrazolo [1,5-alpha] pyrimidine, a novel phosphodiesterase-4 inhibitor, in rat plasma by liquid chromatography-tandem mass spectrometry
    Kyeong Ryoon Lee
    Drug Discovery Platform Technology Team, Korea Research Institute of Chemical Technology, Daejeon 305 600, Republic of Korea
    J Chromatogr Sci 51:517-23. 2013
  5. doi request reprint Dose-independent pharmacokinetics of a new peroxisome proliferator-activated receptor-γ agonist, KR-62980, in Sprague-Dawley rats and ICR mice
    Jong Shik Park
    Drug Discovery Platform Technology Team, Korea Research Institute of Chemical Technology, Daejeon, 305 343, Korea
    Arch Pharm Res 34:2051-8. 2011
  6. doi request reprint Determination of a novel TAZ modulator, 2-butyl-5-methyl-6-(pyridine-3-yl)-3-[2'-(1H-tetrazole-5-yl)-biphenyl-4-ylmethyl]-3H imidazo[4,5-b]pyridine] (TM-25659) in rat plasma by liquid chromatography-tandem mass spectrometry
    Sung Heum Choi
    Drug Discovery Platform Technology Team, Medicinal Science Division, Korea Research Institute of Chemical Technology, Daejon 305 600, South Korea
    J Pharm Biomed Anal 63:47-52. 2012
  7. ncbi request reprint Pharmacokinetics and pharmacodynamics of KR-66223, a novel DPP-4 inhibitor
    Jin Sook Song
    Drug Discovery Platform Technology Team, Division of Bio organic Science, Korea Research Institute of Chemical Technology, Daejeon
    Drug Metab Pharmacokinet 27:216-22. 2012
  8. doi request reprint Synthesis of LipidGreen2 and its application in lipid and fatty liver imaging
    Hang Suk Chun
    Bioorganic Science Division, Korea Research Institute of Chemical Technology, Jang dong 100, Yuseong, Daejeon, 305 600, South Korea
    Mol Biosyst 9:630-3. 2013
  9. doi request reprint Pharmacokinetic characterization of the novel TAZ modulator TM-25659 using a multicompartment kinetic model in rats and a possibility of its drug-drug interactions in humans
    Kyeong Ryoon Lee
    Drug Discovery Platform Technology Team, Medicinal Science Division, Korea Research Institute of Chemical Technology, Daejeon, South Korea
    Xenobiotica 43:193-200. 2013
  10. doi request reprint Discovery of β-aminoacyl containing thiazolidine derivatives as potent and selective dipeptidyl peptidase IV inhibitors
    Woul Seong Park
    Drug Discovery Division, Korea Research Institute of Chemical Technology, Yuseong Gu, Daejeon, Republic of Korea
    Bioorg Med Chem Lett 21:1366-70. 2011

Collaborators

  • Jin Hee Ahn
  • Jeong Ho Hong
  • Hyae Gyeong Cheon
  • Eun Sook Hwang
  • Nam Sook Kang
  • Ji Young Park
  • Young Tae Chang
  • Chi Hyun Kim
  • Eun Jeong Choi
  • Bok Sil Hong
  • Sung Hoon Ahn
  • Jin Sook Song
  • Kyeong Ryoon Lee
  • Min Sun Kim
  • Hang Suk Chun
  • Sung Heum Choi
  • Min Koo Choi
  • Byung Hoi Lee
  • Jae Hong Lee
  • Myoung Joo Park
  • Yoon Jee Chae
  • Im Sook Song
  • Sang Dal Rhee
  • Hee Yeon Won
  • Zhi Zheng
  • Dae Seop Shin
  • Hyewon Seo
  • Nak Jeong Kim
  • Jong Hyun Jeon
  • Ju Hoon So
  • Dong Ju Jeon
  • Seung Kyu Kang
  • Ki Young Kim
  • Kihyun Lee
  • Sung Eun Yoo
  • Hana Jeong
  • Se Hoan Kim
  • Kwang Il Kwon
  • Woul Seong Park
  • Kwang Rok Kim
  • Gil Nam Lee
  • Sun Hye Shin
  • Dae Seok Yoo
  • Jaechun Woo
  • Sun Sil Choi
  • Mihwa Kwon
  • Sunjoo Ahn
  • Nak Jung Kim
  • Jae Ho Ryu
  • Woon Ki Cho
  • So Hee Im
  • Eun Young Kwak
  • Haushabhau S Pagire
  • Hee Chung Chung
  • Hwang Eui Cho
  • Sung Hum Choi
  • Jae Chun Woo
  • Dong Cheul Moon
  • Hyun Jin Kwon
  • Sung Hack Lee
  • Eun Hye Lee
  • Dong Hyun Song
  • Duck Chan Ha
  • Stephen Edward Schneider
  • Yeong Lim Choi
  • Hyeongjin Roh
  • Youmi Rhee
  • Mi Sik Shin
  • Peter Silinski
  • Joo Yeon Lee
  • Sung Wook Kwon
  • So Young Chu
  • Zong Sik Park
  • Jin Ah Lee
  • Jeong Won Seo
  • Mi Ae Jun
  • Qing Ri Jin
  • Su Min Jang
  • Eun Jung Jang
  • Sung Soo Kim
  • Hyeong Jin Rho
  • Banda Narsaiah
  • Hee Yun Kim
  • Jung Woo Chae
  • Yu Ri Lee
  • Jie Oh Lee

Detail Information

Publications24

  1. pmc Prominent bone loss mediated by RANKL and IL-17 produced by CD4+ T cells in TallyHo/JngJ mice
    Hee Yeon Won
    Division of Life and Pharmaceutical Sciences, College of Pharmacy, Center for Cell Signaling and Drug Discovery Research, Ewha Womans University, Seoul, Korea
    PLoS ONE 6:e18168. 2011
    ..Accordingly, we propose that TH mice could constitute a beneficial model for osteoporosis...
  2. pmc Selective inhibition of activated stellate cells and protection from carbon tetrachloride-induced liver injury in rats by a new PPARgamma agonist KR62776
    Myung Ae Bae
    Drug Discovery Platform Technology Team, Medicinal Science Division, Korea Research Institute of Chemical Technology, Daejon, 305 600, Korea
    Arch Pharm Res 33:433-42. 2010
    ..Overall, these results suggest that KR62776 may have potential in the chemoprevention of liver fibrosis/cirrhosis...
  3. doi request reprint Determination of PF-04620110, a novel inhibitor of diacylglycerol acyltransferase-1, in rat plasma using liquid chromatography-tandem mass spectrometry and its application in pharmacokinetic studies
    Kyeong Ryoon Lee
    Drug Discovery Platform Technology Team, Korea Research Institute of Chemical Technology, Daejon, 305 343, Republic of Korea
    Biomed Chromatogr 27:846-52. 2013
    ..PF-04620110 concentrations in the rat plasma samples could be measured up to 24 h after intravenous or oral administration of PF-04620110, suggesting that the assay is useful for pharmacokinetic studies in rats...
  4. doi request reprint Determination of 2-aryl-7(3',4'-dialkoxyphenyl)-pyrazolo [1,5-alpha] pyrimidine, a novel phosphodiesterase-4 inhibitor, in rat plasma by liquid chromatography-tandem mass spectrometry
    Kyeong Ryoon Lee
    Drug Discovery Platform Technology Team, Korea Research Institute of Chemical Technology, Daejeon 305 600, Republic of Korea
    J Chromatogr Sci 51:517-23. 2013
    ..PDE-310 concentrations were readily measured in rat plasma samples up to 8 h after an intravenous administration of PDE-310, suggesting that the assay is practically useful...
  5. doi request reprint Dose-independent pharmacokinetics of a new peroxisome proliferator-activated receptor-γ agonist, KR-62980, in Sprague-Dawley rats and ICR mice
    Jong Shik Park
    Drug Discovery Platform Technology Team, Korea Research Institute of Chemical Technology, Daejeon, 305 343, Korea
    Arch Pharm Res 34:2051-8. 2011
    ..These data suggest that KR-62980 is not significantly dose dependent in rats or mice, although it may disappear rapidly from the systemic circulation via metabolism in the liver...
  6. doi request reprint Determination of a novel TAZ modulator, 2-butyl-5-methyl-6-(pyridine-3-yl)-3-[2'-(1H-tetrazole-5-yl)-biphenyl-4-ylmethyl]-3H imidazo[4,5-b]pyridine] (TM-25659) in rat plasma by liquid chromatography-tandem mass spectrometry
    Sung Heum Choi
    Drug Discovery Platform Technology Team, Medicinal Science Division, Korea Research Institute of Chemical Technology, Daejon 305 600, South Korea
    J Pharm Biomed Anal 63:47-52. 2012
    ..The intra- and inter-batch precisions were 3.17-15.95% and the relative error was 0.38-10.82%. The developed assay was successfully applied to a pharmacokinetic study of TM-25659 administered intravenously (10 mg/kg) to rats...
  7. ncbi request reprint Pharmacokinetics and pharmacodynamics of KR-66223, a novel DPP-4 inhibitor
    Jin Sook Song
    Drug Discovery Platform Technology Team, Division of Bio organic Science, Korea Research Institute of Chemical Technology, Daejeon
    Drug Metab Pharmacokinet 27:216-22. 2012
    ..31 L/h/kg, 0.1 L/kg, 2.4 L/kg, and 3 ng/mL, respectively. These results can serve as a valuable foundation for future clinical trials...
  8. doi request reprint Synthesis of LipidGreen2 and its application in lipid and fatty liver imaging
    Hang Suk Chun
    Bioorganic Science Division, Korea Research Institute of Chemical Technology, Jang dong 100, Yuseong, Daejeon, 305 600, South Korea
    Mol Biosyst 9:630-3. 2013
    ..We also demonstrate the application of LipidGreen2 for detecting fatty liver...
  9. doi request reprint Pharmacokinetic characterization of the novel TAZ modulator TM-25659 using a multicompartment kinetic model in rats and a possibility of its drug-drug interactions in humans
    Kyeong Ryoon Lee
    Drug Discovery Platform Technology Team, Medicinal Science Division, Korea Research Institute of Chemical Technology, Daejeon, South Korea
    Xenobiotica 43:193-200. 2013
    ..In conclusion, the pharmacokinetics of TM-25659 was characterized for intravenous and oral administration at doses of 0.5-5 and 2-10 mg/kg, respectively. TM-25659 was eliminated primarily by hepatic metabolism and urinary excretion...
  10. doi request reprint Discovery of β-aminoacyl containing thiazolidine derivatives as potent and selective dipeptidyl peptidase IV inhibitors
    Woul Seong Park
    Drug Discovery Division, Korea Research Institute of Chemical Technology, Yuseong Gu, Daejeon, Republic of Korea
    Bioorg Med Chem Lett 21:1366-70. 2011
    ..Compound 2db, an ester prodrug of 2da, showed good in vivo DPP-IV inhibition after oral administration in rat and dog models...
  11. doi request reprint Determination of 2-(3-benzoyl)-4-hydroxy-1,1-dioxo-2H-1,2-benzothiazine-2-yl-1-phenylethanone by liquid chromatography-tandem mass spectrometry
    Zhi Zheng
    1Drug Discovery Platform Technology Research Group, Korea Research Institute of Chemical Technology KRICT, Yuseong Gu, Daejeon, 305 600, Korea
    J Chromatogr Sci 52:406-12. 2014
    ..The concentration of KR-66344 was readily measurable in rat plasma up to 24 h post-dose after an oral administration, suggesting that current assay is applicable to pharmacokinetic studies for KR-66344. ..
  12. pmc Spontaneous and aging-dependent development of arthritis in NADPH oxidase 2 deficiency through altered differentiation of CD11b+ and Th/Treg cells
    Kihyun Lee
    Division of Life and Pharmaceutical Sciences, College of Pharmacy, and Center for Cell Signaling and Drug Discovery Research, Ewha Womans University, Seoul 120 750, Korea
    Proc Natl Acad Sci U S A 108:9548-53. 2011
    ....
  13. ncbi request reprint Preclinical pharmacokinetics of PDE-310, a novel PDE4 inhibitor
    Jin Sook Song
    Drug Discovery Platform Technology Team, Division of Bio organic Science, Korea Research Institute of Chemical Technology, Republic of Korea
    Drug Metab Pharmacokinet 26:192-200. 2011
    ..PDE-310 exhibited high oral bioavailability (>70%) and was distributed well to various tissues except brain and testis...
  14. doi request reprint Predicted drug-induced bradycardia related cardio toxicity using a zebrafish in vivo model is highly correlated with results from in vitro tests
    Myoung Joo Park
    Bioorganic Science Division, Korea Research Institute of Chemical Technology, Jang dong 100, Yuseong, Daejeon, 305 600, South Korea
    Toxicol Lett 216:9-15. 2013
    ..The observed and predicted HBR% for the compounds in zebrafish were well-correlated (R(2)=0.948). Therefore, the proposed models were useful for prediction of drug-induced bradycardia related cardio toxicity...
  15. doi request reprint LC-MS-based method for the qualitative and quantitative analysis of the novel PPARγ agonist KR-62980
    Min Sun Kim
    Drug Discovery Platform Technology Team, Medicinal Science Division, Korea Research Institute of Chemical Technology, Daejon, South Korea
    Methods Mol Biol 952:313-23. 2013
    ..The coefficients of variation of intra- and inter-assay were 1.2-10.6% and the relative error was 0.8-13.2%. The method was validated and successfully applied to the pharmacokinetic study of KR-62980 in rat...
  16. doi request reprint Pharmacokinetic characterization of decursinol derived from Angelica gigas Nakai in rats
    Jin Sook Song
    Drug Discovery Platform Technology Team, Division of Bio organic Science, Korea Research Institute of Chemical Technology, Daejeon, Republic of Korea
    Xenobiotica 41:895-902. 2011
    ..4-0.9 h) over the dose range studied. In addition, dose-dependent absorption and elimination were observed at 20 mg/kg...
  17. doi request reprint Transport characteristics and transporter-based drug-drug interactions of TM-25659, a novel TAZ modulator
    Min Koo Choi
    College of Pharmacy, Dankook University, Cheonan, Korea
    Biopharm Drug Dispos 35:183-94. 2014
    ....
  18. doi request reprint KR-62980 suppresses lipid metabolism through inhibition of cytosolic NADP isocitrate dehydrogenase in zebrafish
    Hang Suk Chun
    Drug Discovery Platform Technology Team, Korea Research Institute of Chemical Technology, Daejeon, Republic of Korea
    Zebrafish 11:122-8. 2014
    ..Further, KR-62980 substantially suppressed cICDH in adipocytes and zebrafish. These results suggest that cICDH may be one of the targets of KR-62980 responsible for weight gain and adipogenesis...
  19. pmc Hesperedin promotes MyoD-induced myogenic differentiation in vitro and in vivo
    Hana Jeong
    College of Pharmacy, Division of Life and Pharmaceutical Sciences, Center for Cell Signaling and Drug Discovery Research, Ewha Womans University, Seoul, Korea
    Br J Pharmacol 163:598-608. 2011
    ..Murine bone marrow mesenchymal stem cells undergo myogenic differentiation as well as osteogenic differentiation. We therefore explored whether hesperedin modulates muscle cell differentiation...
  20. doi request reprint Determination of a peroxisome proliferator-activated receptor γ agonist, 1-(trans-methylimino-N-oxy)-6-(2-morpholinoethoxy-3-phenyl-1H-indene-2-carboxylic acid ethyl ester (KR-62980) in rat plasma by liquid chromatography-tandem mass spectrometry
    Min Sun Kim
    Drug Discovery Platform Technology Team, Medicinal Science Division, Korea Research Institute of Chemical Technology, Daejon 305 600, Republic of Korea
    J Pharm Biomed Anal 54:121-6. 2011
    ..99 and the lower limit of quantification was 0.01 μg/ml. The mean of intra- and inter-assay precisions was 2.1 and 9.3%. The method was validated and successfully applied to the pharmacokinetic study of KR-62980 in rat...
  21. doi request reprint Synthesis of a new fluorescent small molecule probe and its use for in vivo lipid imaging
    Jae Hong Lee
    Bioorganic Division, Korea Research Institute of Chemical Technology, Daejeon, 305 600, Korea
    Chem Commun (Camb) 47:7500-2. 2011
    ..The utility of LipidGreen as a drug screening platform for fat regulation was also demonstrated in live zebrafish...
  22. ncbi request reprint Identification of cyclicsulfonamide derivatives with an acetamide group as 11β-hydroxysteroid dehydrogenase 1 inhibitors
    Se Hoan Kim
    Department of Chemistry, Korea University, Seoul, Korea
    Chem Pharm Bull (Tokyo) 59:46-52. 2011
    ..Also, a docking study explained the activity difference between human and mouse 11β-HSD1...
  23. doi request reprint Inhibitory effects of ketoconazole and rifampin on OAT1 and OATP1B1 transport activities: considerations on drug-drug interactions
    Min Koo Choi
    Department of Pharmaceutics, College of Pharmacy, Dankook University, Cheonan, Korea
    Biopharm Drug Dispos 32:175-84. 2011
    ....
  24. doi request reprint Discovery of cannabinoid-1 receptor antagonists by virtual screening
    Gil Nam Lee
    Korea Research Institute of Chemical Technology, Yuseong Gu, Daejeon, Republic of Korea
    Bioorg Med Chem Lett 20:5130-2. 2010
    ..The most active compound, including thiazole-4-one moiety, showed an activity value of 125 nM IC(50), with a good PK profile...