Soohyun Kim

Summary

Affiliation: Konkuk University
Country: Korea

Publications

  1. pmc Chungsim-Yeunja-Tang decreases the inflammatory response in peripheral blood mononuclear cells from patients with cerebral infarction through an NF-κB dependent mechanism
    Hyun Ja Jeong
    BioChip Research Center, Hoseo University, Asan, Chungnam, Republic of Korea
    J Neuroinflammation 7:85. 2010
  2. doi request reprint Generation of anti-proteinase 3 monoclonal antibodies and development of immunological methods to detect endogenous proteinase 3
    Suyoung Bae
    Laboratory of Cytokine Immunology, Medical Immunology Center, Konkuk University, Seoul, Korea
    Hybridoma (Larchmt) 29:17-26. 2010
  3. pmc Contradictory functions (activation/termination) of neutrophil proteinase 3 enzyme (PR3) in interleukin-33 biological activity
    Suyoung Bae
    Laboratory of Cytokine Immunology, Department of Biomedical Science and Technology, Konkuk University, 120 Neungdong ro, Gwangjin gu, Seoul 143 701, Korea
    J Biol Chem 287:8205-13. 2012
  4. pmc Effect of recombinant α1-antitrypsin Fc-fused (AAT-Fc)protein on the inhibition of inflammatory cytokine production and streptozotocin-induced diabetes
    Siyoung Lee
    Laboratory of Cytokine Immunology, Department of Biomedical Science and Technology, Konkuk University, Seoul, Korea
    Mol Med 19:65-71. 2013
  5. doi request reprint Amino acid differences in interferon-tau (IFN-τ) of Bos taurus Coreanae and Holstein
    Dongjun Kang
    College of Veterinary Medicine, Konkuk University, 120 Neungdong ro, Gwangjin gu, Seoul 143 701, Republic of Korea
    Cytokine 59:273-9. 2012
  6. pmc Identification of constitutively active interleukin 33 (IL-33) splice variant
    Jaewoo Hong
    Laboratory of Cytokine Immunology, Medical Immunology Center, Konkuk University, Seoul, Korea
    J Biol Chem 286:20078-86. 2011
  7. doi request reprint Characterizing antiviral mechanism of interleukin-32 and a circulating soluble isoform in viral infection
    Suyoung Bae
    Laboratory of Cytokine Immunology, Department of Biomedical Science and Technology, Konkuk University, Seoul 143 701, Republic of Korea
    Cytokine 58:79-86. 2012
  8. pmc Paradoxical effects of constitutive human IL-32{gamma} in transgenic mice during experimental colitis
    Jida Choi
    Laboratory of Cytokine Immunology, Medical Immunology Center, Department of Bioscience and Biotechnology, School of Medicine, Konkuk University, Seoul 143 701, Korea
    Proc Natl Acad Sci U S A 107:21082-6. 2010
  9. doi request reprint The inhibitory function of Fc-ST2 depends on cell type; IL-1RAcP and ST2 are necessary but insufficient for IL-33 activity
    Kwangwon Hong
    Department of Biomedical Science and Technology, Konkuk University, Gwangjin gu, Seoul, Korea
    Immunol Res 56:122-30. 2013
  10. doi request reprint Recombinant Fc-IL-18BPc isoform inhibits IL-18-induced cytokine production
    Kwangwon Hong
    Laboratory of Cytokine Immunology, Department of Biomedical Sciences and Technology, Konkuk University Medical Center, School of Medicine, Konkuk University, Seoul, Korea
    Hybridoma (Larchmt) 31:99-104. 2012

Collaborators

  • Charles A Dinarello
  • Jin Tae Hong
  • Hyunjung Jade Lim
  • Hyeong Cheol Park
  • Xiyuan Bai
  • Suyoung Bae
  • Siyoung Lee
  • Hyunjhung Jhun
  • Jida Choi
  • Areum Kwak
  • Kwangwon Hong
  • Eunsom Kim
  • Seunghyun Jo
  • Soyoon Ryoo
  • Youngmin Lee
  • Erk Her
  • Taebong Kang
  • Dongjun Kang
  • Jongho Lee
  • Tae Bong Kang
  • Stefano Toldo
  • Sojung Kwon
  • Keeho Song
  • Yong Gil Kim
  • Byunghyun Chung
  • Eusom Kim
  • Sangmin Jeong
  • Joongbok Lee
  • Gyujin Rho
  • Seungyoung Park
  • Jun Jaekal
  • Wonhyuk Choi
  • Doyoung Yoon
  • Hyun Ja Jeong
  • Hyunwoo Kim
  • Benjamin W Van Tassell
  • Yong Sung Kim
  • Eleonora Mezzaroma
  • Adolfo G Mauro
  • Dong Ki Choi
  • Carlo Marchetti
  • Antonio Abbate
  • Sulah Youn
  • Jungmin Lee
  • Busun Kim
  • Scott W Rose
  • Do Young Yoon
  • Kwang Jun Oh
  • Sukha Lee
  • Anshul Shyam Sobti
  • Yoojung Lim
  • Tae Sung Kim
  • Soyoung Choi
  • Hyejin Shin
  • You Sook Cho
  • Sungnoh Hong
  • Yong Beom Park
  • Jinsoo Han
  • Eun Young Song
  • Chang Keun Lee
  • Seounghyun Jo
  • Hokee Yum
  • Bin Yoo
  • Woe Yeon Kim
  • Kwangjun Oh
  • Kangchang Kim
  • Dae Jin Yun
  • Hyunjhung Jeon
  • Youngbum Choi
  • Young Yang
  • Tania Azam
  • Min Ho Kim
  • In Young Choi
  • Jeonghwan Kim
  • Hyung Min Kim
  • Phil Dong Moon

Detail Information

Publications26

  1. pmc Chungsim-Yeunja-Tang decreases the inflammatory response in peripheral blood mononuclear cells from patients with cerebral infarction through an NF-κB dependent mechanism
    Hyun Ja Jeong
    BioChip Research Center, Hoseo University, Asan, Chungnam, Republic of Korea
    J Neuroinflammation 7:85. 2010
    ..Chungsim-Yeunja-Tang (CYT) has been used as a medicine for cerebral infarction (CI) patients in Korea. The objective of this study was to determine precisely the effect of CYT on CI patients using peripheral blood mononuclear cells (PBMCs)...
  2. doi request reprint Generation of anti-proteinase 3 monoclonal antibodies and development of immunological methods to detect endogenous proteinase 3
    Suyoung Bae
    Laboratory of Cytokine Immunology, Medical Immunology Center, Konkuk University, Seoul, Korea
    Hybridoma (Larchmt) 29:17-26. 2010
    ..In addition, new MAbs detect endogenous PR3 from normal human plasma and urine with high specificity. The new anti-PR3 MAbs will be an essential tool for investigating the role of PR3 in inflammatory and autoimmune diseases...
  3. pmc Contradictory functions (activation/termination) of neutrophil proteinase 3 enzyme (PR3) in interleukin-33 biological activity
    Suyoung Bae
    Laboratory of Cytokine Immunology, Department of Biomedical Science and Technology, Konkuk University, 120 Neungdong ro, Gwangjin gu, Seoul 143 701, Korea
    J Biol Chem 287:8205-13. 2012
    ..The human IL-33/p1 was highly active, but human IL-33/p2 and p3 proteins were inactive. Our results suggest the dual functions (activation/termination) of PR3 in IL-33 biological activity...
  4. pmc Effect of recombinant α1-antitrypsin Fc-fused (AAT-Fc)protein on the inhibition of inflammatory cytokine production and streptozotocin-induced diabetes
    Siyoung Lee
    Laboratory of Cytokine Immunology, Department of Biomedical Science and Technology, Konkuk University, Seoul, Korea
    Mol Med 19:65-71. 2013
    ..Interestingly, we also found that plasma-derived AAT specifically inhibited the enzymatic activity of elastase but that AAT-Fc had no inhibitory effect on elastase activity...
  5. doi request reprint Amino acid differences in interferon-tau (IFN-τ) of Bos taurus Coreanae and Holstein
    Dongjun Kang
    College of Veterinary Medicine, Konkuk University, 120 Neungdong ro, Gwangjin gu, Seoul 143 701, Republic of Korea
    Cytokine 59:273-9. 2012
    ..The recombinant IFN-τ protein of B. T. Coreanae and Holstein properly induced the expression of antiviral genes including 2',5'-oligoadenylate synthetase (OAS) and Mx GTPase 1 (Mx-1)...
  6. pmc Identification of constitutively active interleukin 33 (IL-33) splice variant
    Jaewoo Hong
    Laboratory of Cytokine Immunology, Medical Immunology Center, Konkuk University, Seoul, Korea
    J Biol Chem 286:20078-86. 2011
    ..Further investigation of the spIL-33 expression pattern may contribute to understanding the involvement of IL-33 in inflammatory disorders...
  7. doi request reprint Characterizing antiviral mechanism of interleukin-32 and a circulating soluble isoform in viral infection
    Suyoung Bae
    Laboratory of Cytokine Immunology, Department of Biomedical Science and Technology, Konkuk University, Seoul 143 701, Republic of Korea
    Cytokine 58:79-86. 2012
    ..The present results suggest that IL-32γ expression and its genetic variation in individual could be an important aspect of viral infections...
  8. pmc Paradoxical effects of constitutive human IL-32{gamma} in transgenic mice during experimental colitis
    Jida Choi
    Laboratory of Cytokine Immunology, Medical Immunology Center, Department of Bioscience and Biotechnology, School of Medicine, Konkuk University, Seoul 143 701, Korea
    Proc Natl Acad Sci U S A 107:21082-6. 2010
    ..Thus IL-32γ emerges as an example of how innate inflammation worsens as well as protects intestinal integrity...
  9. doi request reprint The inhibitory function of Fc-ST2 depends on cell type; IL-1RAcP and ST2 are necessary but insufficient for IL-33 activity
    Kwangwon Hong
    Department of Biomedical Science and Technology, Konkuk University, Gwangjin gu, Seoul, Korea
    Immunol Res 56:122-30. 2013
    ..Our results suggest that an additional receptor component may participate in the biological activity of IL-33...
  10. doi request reprint Recombinant Fc-IL-18BPc isoform inhibits IL-18-induced cytokine production
    Kwangwon Hong
    Laboratory of Cytokine Immunology, Department of Biomedical Sciences and Technology, Konkuk University Medical Center, School of Medicine, Konkuk University, Seoul, Korea
    Hybridoma (Larchmt) 31:99-104. 2012
    ..This is the first time that expressed recombinant human Fc-IL-18BPc has been examined for its biological activity on IL-18-induced IFNγ in human PBMC and IL-6 in A549/IL-18Rβ...
  11. doi request reprint Development of isoform-specific monoclonal antibodies against human IL-18 binding protein
    Siyoung Lee
    Department of Immunology, College of Medicine, Konkuk University, Chungju City, Chungbuk, Korea
    Hybridoma (Larchmt) 29:517-24. 2010
    ..The isoform-specific anti-human IL-18BP MAb may be a useful tool in categorizing a distinct group of patients from various autoimmune diseases related to IL-18BP...
  12. doi request reprint Elevated interleukin-32 expression in granulomatosis with polyangiitis
    Suyoung Bae
    Laboratory of Cytokine Immunology, Konkuk University, 120 Neungdong ro, Gwangjin gu, Seoul 143 701 Korea
    Rheumatology (Oxford) 51:1979-88. 2012
    ....
  13. doi request reprint Cloning and characterization of bovine interleukin-32 beta isoform
    Jun Jaekal
    Laboratory of Cytokine Immunology, Medical Immunology Center, Institute of Biomedical Science and Technology, Konkuk University, 1 Hwayang dong, Gwangjin gu, Seoul 143 701, Republic of Korea
    Vet Immunol Immunopathol 137:166-71. 2010
    ..Stimulation by recombinant bovine IL-32 induced mRNA for TNFalpha and IL-6 in bovine PBMC suggesting conservation of the biological activity and function in cattle...
  14. doi request reprint Development of an interleukin (IL)-33 sandwich ELISA kit specific for mature IL-33
    Eunsom Kim
    a Laboratory of Cytokine Immunology, Department of Biomedical Science and Technology, Konkuk University, Seoul, Korea
    J Immunoassay Immunochem 37:585-96. 2016
    ..This article describes the methods for a newly developed IL-33 ELISA kit that is specific for mature IL-33 and may be used to analyze bioactive mature IL-33 in various immunological diseases. ..
  15. doi request reprint IL-32γ overexpression accelerates streptozotocin (STZ)-induced type 1 diabetes
    Hyunjhung Jhun
    Laboratory of Cytokine Immunology, Department of Biomedical Science and Technology, Konkuk University, Seoul 143 701, Republic of Korea
    Cytokine 69:1-5. 2014
    ..These data indicate that the overexpression of IL-32γ contributes to initial islet β-cells injury and inflammation in pancreas and aggravates STZ-induced type 1 diabetes. ..
  16. doi request reprint Suppressing IL-32 in monocytes impairs the induction of the proinflammatory cytokines TNFalpha and IL-1beta
    Jaewoo Hong
    Laboratory of Cytokine Immunology, Medical Immunology Center, Institute of Biomedical Science and Technology, Konkuk University 1 Hwayang dong, Gwangjin gu, Seoul 143 701, Republic of Korea
    Cytokine 49:171-6. 2010
    ..IL-32 production leads to major proinflammatory cytokine production during the initial immune response...
  17. ncbi request reprint Effect of lipopolysaccharide (LPS) on mouse model of steroid-induced avascular necrosis in the femoral head (ANFH)
    Soyoon Ryoo
    Laboratory of Cytokine Immunology, Department Biomedical Sciences and Technology, Konkuk University, Seoul, 143 701, Republic of Korea
    J Microbiol Biotechnol 24:394-400. 2014
    ..Collectively, the effect of repeated LPS on the pathogenesis of GC-induced ANFH was associated with the TNFα level in the femoral head, but the pathogenesis did not correspond to cytokine levels in immune tissues. ..
  18. doi request reprint Interleukin-32 gamma specific monoclonal antibody and developing IL-32 specific ELISA
    Siyoung Lee
    Department of Immunology, College of Medicine, Konkuk University, Chungju City, Chungbuk, Korea
    Hybridoma (Larchmt) 29:501-9. 2010
    ..These monoclonal antibodies will be helpful in investigating the precise function of IL-32 in immune responses and in autoinflammatory diseases...
  19. doi request reprint Monoclonal antibodies against recombinant AtHOS15
    Siyoung Lee
    Laboratory of Cytokine Immunology, Department of Biomedical Science and Technology, Konkuk University, Gwangjin gu, Seoul, Korea
    Hybridoma (Larchmt) 31:118-24. 2012
    ..In particular, the anti-HOS15 MAbs will be essential tools to investigate the role of HOS15 in the regulation of tolerance to environmental stresses in plants...
  20. doi request reprint Reconstitution of ST2 (IL-1R4) specific for IL-33 activity; no suppression by IL-1Ra though a common chain IL-1R3 (IL-1RAcP) shared with IL-1
    Seunghyun Jo
    Laboratory of Cytokine Immunology, Department of Biomedical Science and Technology, Konkuk University, 120 Neungdong ro, Gwangjin gu, Seoul 143 701, Republic of Korea College of Veterinary Medicine, Konkuk University, 120 Neungdong ro, Gwangjin gu, Seoul 143 701, Republic of Korea
    Cytokine 83:33-40. 2016
    ..This result demonstrates for the first time the reconstitution of ST2 in A549 human lung epithelial cell line and verified its function in IL-33-mediated cytokine production and signal transduction. ..
  21. ncbi request reprint Proteinase 3-processed form of the recombinant IL-32 separate domain
    Sunjong Kim
    Department of Respiratory Medicine, Konkuk University, Korea
    BMB Rep 41:814-9. 2008
    ..Interestingly, the N-terminal IL-32 isoform gamma separate domain evidenced the highest levels of biological activity among the IL-32 separate domains...
  22. doi request reprint Neutrophil proteinase 3 induces diabetes in a mouse model of glucose tolerance
    Suyoung Bae
    Laboratory of Cytokine Immunology, Institute of Biomedical Science and Technology, College of Medicine, Konkuk University, Seoul, Republic of Korea
    Endocr Res 37:35-45. 2012
    ..As such, PR3 can be considered as an inflammatory enzyme directly linking inflammation to type 2 diabetes through downregulation of insulin-like growth factor-1/IGFBP3...
  23. ncbi request reprint Intracellular interleukin (IL)-1 family cytokine processing enzyme
    Areum Kwak
    Laboratory of Cytokine Immunology, Department of Biomedical Science and Technology, Konkuk University, 120 Neungdong ro, Gwangjin gu, Seoul, 05029, Korea
    Arch Pharm Res 39:1556-1564. 2016
    ..In this review, we describe all eleven IL-1 family ligand processing enzymes, mature ligand functions, and mode of receptor conformation...
  24. doi request reprint Recombinant Human Alpha-1 Antitrypsin-Fc Fusion Protein Reduces Mouse Myocardial Inflammatory Injury After Ischemia-Reperfusion Independent of Elastase Inhibition
    Stefano Toldo
    VCU Pauley Heart Center, Virginia Commonwealth University, Richmond, VA VCU Johnson Research Laboratories, Virginia Commonwealth University, Richmond, Va Department of Surgery, Virginia Commonwealth University, Richmond, VA Department of Pharmacotherapy and Outcomes Science, Virginia Commonwealth University, Richmond, VA Department of Biomedical Science and Technology, Konkuk University, Seoul, Korea Department of Medicine, University of Colorado, Denver, CO and Department of Experimental Medicine, Radbound University Medical Center, Nijmegen, The Netherlands
    J Cardiovasc Pharmacol 68:27-32. 2016
    ..The aim of the present study was to assess the properties of a recombinant protein composed of human AAT fused to the human immunoglobulin (Ig) G1 Fc fragment (rhAAT-Fc) in experimental myocardial infarction...
  25. doi request reprint Application of a novel cell-permeable peptide-driven protein delivery in mouse blastocysts
    Sojung Kwon
    Department of Biomedical Science and Technology, Institute of Biomedical Science and Technology, Konkuk University, 120 Neungdong ro, Gwangjin gu, Seoul 143 701, Republic of Korea
    Reproduction 146:145-53. 2013
    ..Collectively, we show that LDP12-driven protein delivery is a fast and convenient method applicable to mouse blastocysts and reproductive cancer cells. ..