H Kim

Summary

Affiliation: Kangwon National University
Country: Korea

Publications

  1. ncbi request reprint Selenium deficiency potentiates methamphetamine-induced nigral neuronal loss; comparison with MPTP model
    H Kim
    Section of Pharmacology and Toxicology, Department of Pharmacy, College of Pharmacy, Kangwon National University, Korea Institute of Drug Abuse, Chunchon, South Korea
    Brain Res 862:247-52. 2000
  2. ncbi request reprint Protection of methamphetamine nigrostriatal toxicity by dietary selenium
    H C Kim
    Department of Pharmacy, College of Pharmacy, Kangwon National University, Korea Institute of Drug Abuse, Chunchon, South Korea
    Brain Res 851:76-86. 1999
  3. ncbi request reprint Prolonged exposure to cigarette smoke blocks the neurotoxicity induced by kainic acid in rats
    H C Kim
    Department of Pharmacy, College of Pharmacy, Kangwon National University, Korea Institute of Drug Abuse, Chunchon
    Life Sci 66:317-26. 2000
  4. ncbi request reprint An immunocytochemical study of mitochondrial manganese-superoxide dismutase in the rat hippocampus after kainate administration
    H C Kim
    Section of Pharmacology and Toxicology, Department of Pharmacy, Kangwon National University, Korea Institute of Drug Abuse, Chunchon, South Korea
    Neurosci Lett 281:65-8. 2000
  5. ncbi request reprint Dextromethorphan affects cocaine-mediated behavioral pattern in parallel with a long-lasting Fos-related antigen-immunoreactivity
    H C Kim
    Department of Pharmacy, College of Pharmacy, Korea Institute of Drug Abuse, Kangwon National University, Chunchon, South Korea
    Life Sci 69:615-24. 2001
  6. ncbi request reprint Oxidative damage causes formation of lipofuscin-like substances in the hippocampus of the senescence-accelerated mouse after kainate treatment
    Hyoung Chun Kim
    Neurotoxicology Program, Department of Pharmacy, College of Pharmacy, Kangwon National University, 200 701, Chunchon, South Korea
    Behav Brain Res 131:211-20. 2002
  7. ncbi request reprint New morphinan derivatives with negligible psychotropic effects attenuate convulsions induced by maximal electroshock in mice
    Hyoung Chun Kim
    Neurotoxicology Program, College of Pharmacy, Korea Institute of Drug Abuse, Kangwon National University, Chunchon 200 701, South Korea
    Life Sci 72:1883-95. 2003
  8. ncbi request reprint Kainate treatment alters TGF-beta3 gene expression in the rat hippocampus
    Hyoung Chun Kim
    Neurotoxicology Program, College of Pharmacy, Korea Institute of Drug Abuse, Kangwon National University, Chunchon 200 701, South Korea
    Brain Res Mol Brain Res 108:60-70. 2002
  9. ncbi request reprint Effects of dextromethorphan on the seizures induced by kainate and the calcium channel agonist BAY k-8644: comparison with the effects of dextrorphan
    H C Kim
    Neurotoxicology Program, Department of Pharmacy, College of Pharmacy, Korea Institute of Drug Abuse, Kangwon National University, Chunchon 200 701, South Korea
    Behav Brain Res 120:169-75. 2001
  10. ncbi request reprint Metabolism to dextrorphan is not essential for dextromethorphan's anticonvulsant activity against kainate in mice
    Hyoung Chun Kim
    Neurotoxicology Program, Department of Pharmacy, College of Pharmacy, Korea Institute of Drug Abuse, Kangwon National University, Chunchon 200 701, South Korea
    Life Sci 72:769-83. 2003

Collaborators

Detail Information

Publications72

  1. ncbi request reprint Selenium deficiency potentiates methamphetamine-induced nigral neuronal loss; comparison with MPTP model
    H Kim
    Section of Pharmacology and Toxicology, Department of Pharmacy, College of Pharmacy, Kangwon National University, Korea Institute of Drug Abuse, Chunchon, South Korea
    Brain Res 862:247-52. 2000
    ..However, different mechanisms in the thermoregulation mediated by MA or MPTP remain to be further determined...
  2. ncbi request reprint Protection of methamphetamine nigrostriatal toxicity by dietary selenium
    H C Kim
    Department of Pharmacy, College of Pharmacy, Kangwon National University, Korea Institute of Drug Abuse, Chunchon, South Korea
    Brain Res 851:76-86. 1999
    ..Even though Cu,Zn-SOD activity was significantly elevated by MA treatment, the role of this enzyme in MA-mediated neurotoxicity is not yet clear...
  3. ncbi request reprint Prolonged exposure to cigarette smoke blocks the neurotoxicity induced by kainic acid in rats
    H C Kim
    Department of Pharmacy, College of Pharmacy, Kangwon National University, Korea Institute of Drug Abuse, Chunchon
    Life Sci 66:317-26. 2000
    ..p.) blocked the neuroprotective effects mediated by CS in a dose-dependent manner. These results indicate that CS exposure provides neuroprotection against the KA insult via nicotinic receptor activation...
  4. ncbi request reprint An immunocytochemical study of mitochondrial manganese-superoxide dismutase in the rat hippocampus after kainate administration
    H C Kim
    Section of Pharmacology and Toxicology, Department of Pharmacy, Kangwon National University, Korea Institute of Drug Abuse, Chunchon, South Korea
    Neurosci Lett 281:65-8. 2000
    ..This suggests that astroglial cells mobilized to synthesize of SOD-2 protein in a response to KA toxicity designed to reduce the oxidative damage...
  5. ncbi request reprint Dextromethorphan affects cocaine-mediated behavioral pattern in parallel with a long-lasting Fos-related antigen-immunoreactivity
    H C Kim
    Department of Pharmacy, College of Pharmacy, Korea Institute of Drug Abuse, Kangwon National University, Chunchon, South Korea
    Life Sci 69:615-24. 2001
    ..However, the role of FRA-IR regulated by DM or/and cocaine remains to be further determined...
  6. ncbi request reprint Oxidative damage causes formation of lipofuscin-like substances in the hippocampus of the senescence-accelerated mouse after kainate treatment
    Hyoung Chun Kim
    Neurotoxicology Program, Department of Pharmacy, College of Pharmacy, Kangwon National University, 200 701, Chunchon, South Korea
    Behav Brain Res 131:211-20. 2002
    ..Therefore, our data suggests that mice in the senescence model are more susceptible to KA-induced seizures/oxidative damage, and that oxidative damage could be one of the casual factors in the accumulation of lipofuscin...
  7. ncbi request reprint New morphinan derivatives with negligible psychotropic effects attenuate convulsions induced by maximal electroshock in mice
    Hyoung Chun Kim
    Neurotoxicology Program, College of Pharmacy, Korea Institute of Drug Abuse, Kangwon National University, Chunchon 200 701, South Korea
    Life Sci 72:1883-95. 2003
    ..Our results suggest that the new morphinan analogs are promising anticonvulsants that are devoid of PCP-like behavioral side effects, and their anticonvulsant actions may be, in part, mediated via sigma(1) receptors...
  8. ncbi request reprint Kainate treatment alters TGF-beta3 gene expression in the rat hippocampus
    Hyoung Chun Kim
    Neurotoxicology Program, College of Pharmacy, Korea Institute of Drug Abuse, Kangwon National University, Chunchon 200 701, South Korea
    Brain Res Mol Brain Res 108:60-70. 2002
    ..c.v.) significantly attenuated KA-induced seizures and neuronal damages in a dose-related manner. Therefore, our results suggest that TGF-beta3 plays an important role in protective mechanisms against KA-induced neurodegeneration...
  9. ncbi request reprint Effects of dextromethorphan on the seizures induced by kainate and the calcium channel agonist BAY k-8644: comparison with the effects of dextrorphan
    H C Kim
    Neurotoxicology Program, Department of Pharmacy, College of Pharmacy, Korea Institute of Drug Abuse, Kangwon National University, Chunchon 200 701, South Korea
    Behav Brain Res 120:169-75. 2001
    ..They also suggest that DM is a more potent anticonvulsant than DX in the KA and BAY k-8644 seizure models...
  10. ncbi request reprint Metabolism to dextrorphan is not essential for dextromethorphan's anticonvulsant activity against kainate in mice
    Hyoung Chun Kim
    Neurotoxicology Program, Department of Pharmacy, College of Pharmacy, Korea Institute of Drug Abuse, Kangwon National University, Chunchon 200 701, South Korea
    Life Sci 72:769-83. 2003
    ..Combined, our results suggest that metabolism of DM to DX is not essential for DM to exert its effect. They also suggest that DM provides neuroprotection from kainic acid via sigma-1 receptor modulation...
  11. ncbi request reprint Anticonvulsant effects of new morphinan derivatives
    H C Kim
    Neurotoxicology Program, Department of Pharmacy, College of Pharmacy, Korea Institute of Drug Abuse, Kangwon National University, 200 701, Chunchon, South Korea
    Bioorg Med Chem Lett 11:1651-4. 2001
    ..We examined the effects of these compounds on kainic acid (KA)-induced seizures, and on locomotor patterns in rats. We found that compounds 5, 6, and 8 exhibit novel anticonvulsant effects, with negligible psychotropic effects...
  12. ncbi request reprint Changes of hippocampal Cu/Zn-superoxide dismutase after kainate treatment in the rat
    H Kim
    Section of Pharmacology, Department of Pharmacy, College of Pharmacy, Kangwon National University, Chunchon, South Korea
    Brain Res 853:215-26. 2000
    ..Therefore, these alterations might reflect the regulatory role of SOD-1 against oxygen-derived free radical-induced neuronal degeneration after systemic KA administration...
  13. ncbi request reprint Phenidone prevents kainate-induced neurotoxicity via antioxidant mechanisms
    H C Kim
    Neurotoxicology Program, Department of Pharmacy, College of Pharmacy, Kangwon National University, Korea Institute of Drug Abuse, 200 701, Chunchon, South Korea
    Brain Res 874:15-23. 2000
    ..However, a novel anticonvulsant/neuroprotective effect mediated by phenidone remains to be further characterized...
  14. ncbi request reprint Carbetapentane attenuates kainate-induced seizures via sigma-1 receptor modulation
    H C Kim
    Department of Pharmacy, College of Pharmacy, Korea Institute of Drug Abuse, Kangwon National University, Chunchon
    Life Sci 69:915-22. 2001
    ..p.) blocked, in a dose-related manner, the neuroprotection afforded by CB. These results suggest that CB provides neuroprotection against KA insult via sigma-1 receptor modulation...
  15. ncbi request reprint Effect of Rehmannia glutinosa on immediate type allergic reaction
    H Kim
    Department of Oriental Pharmacy, College of Pharmacy, Wonkwang University, Iksan, Chonbuk, South Korea
    Int J Immunopharmacol 20:231-40. 1998
    ..Moreover, RGAE had significant inhibitory effect on anti-DNP IgE-induced tumor necrosis factor-alpha production of RPMC. These results indicate that RGAE may be beneficial in the regulation of immediate type allergic reaction...
  16. ncbi request reprint Characterization and regulation of Schizosaccharomyces pombe gene encoding thioredoxin
    Y Cho
    Division of Life Sciences, College of Natural Sciences, Kangwon National University, Chuncheon 200 701, South Korea
    Biochim Biophys Acta 1518:194-9. 2001
    ..Synthesis of beta-galactosidase from the fusion plasmid was found to be enhanced by hydrogen peroxide, menadione and aluminum chloride. It indicates that the expression of the cloned TRX gene is induced by oxidative stress...
  17. ncbi request reprint Inhibition of immediate type allergic reactions by the aqueous extract of Kum-Hwang-San
    H Kim
    College of Pharmacy, Wonkwang University, Iksan, Chonbuk, South Korea
    Int J Immunopharmacol 20:285-94. 1998
    ..These results indicate that KHS inhibits immediate type allergic reactions by inhibition of histamine release and TNF-alpha secretion from mast cells in vivo and in vitro...
  18. ncbi request reprint Immunostimulation of rat primary astrocytes decreases intracellular ATP level
    C Y Shin
    Department of Pharmacology, College of Pharmacy, Seoul National University, San 56-1, Shillim-dong, Kwanak-Gu, 151-742, Seoul, South Korea
    Brain Res 902:198-204. 2001
    ....
  19. pmc Enhanced hippocampal CA1 LTP but normal spatial learning in inositol 1,4,5-trisphosphate 3-kinase(A)-deficient mice
    K Jun
    National Creative Research Initiatives Center for Calcium and Learning and Department of Life Science, Pohang University of Science and Technology, Korea
    Learn Mem 5:317-30. 1998
    ....
  20. ncbi request reprint Cerebral activation and distribution of inducible hsp110 and hsp70 mRNAs following focal ischemia in rat
    H Kim
    Department of Anatomy, College of Medicine, Korea University, 136-705, Seoul, South Korea
    Toxicology 167:135-44. 2001
    ..Further study is required to characterize the genetic and biochemical nature of rat inducible hsp110 identified in the current study...
  21. ncbi request reprint Cytoprotective effect of Scutellaria baicalensis in CA1 hippocampal neurons of rats after global cerebral ischemia
    Y O Kim
    Department of Herbal Pharmacology, Graduate School of East-West Medical Science, Kyunghee University, 1 Hoegi-Dong, Tongdaemun-ku, Seoul 130-701, Republic of Korea
    J Ethnopharmacol 77:183-8. 2001
    ..Methanol extract of S. baicalensis inhibited microglial tumor necrosis factor-alpha (TNF-alpha) and nitric oxide production, and protected PC12 cells from hydrogen peroxide-induced toxicity in vitro...
  22. ncbi request reprint Stimulation of ERK2 by taurine with enhanced alkaline phosphatase activity and collagen synthesis in osteoblast-like UMR-106 cells
    S Park
    Department of Pharmacology, School of Dentistry, Kyung-Hee University, 130-701, Seoul, Korea
    Biochem Pharmacol 62:1107-11. 2001
    ..A mitogen-activated protein kinase kinase (MEK) inhibitor blocked the taurine-stimulated alkaline phosphatase activity and collagen synthesis. These results suggest that taurine could regulate osteoblast metabolism via ERK2 activation...
  23. pmc Srg3, a mouse homolog of yeast SWI3, is essential for early embryogenesis and involved in brain development
    J K Kim
    School of Biological Sciences and Institute of Molecular Biology and Genetics, Seoul National University, Kwanak gu, Shinlim Dong, Seoul 151 742, Republic of Korea
    Mol Cell Biol 21:7787-95. 2001
    ..Our findings demonstrate that Srg3 is essential for early embryogenesis and plays an important role in the brain development of mice...
  24. ncbi request reprint Molecular cloning and expression of turkey inhibin-alpha and -betaA subunits
    J Ahn
    Department of Animal Science, University of Minnesota, St. Paul 55108, USA
    Poult Sci 80:1690-4. 2001
    ....
  25. ncbi request reprint Induction of caspase-11 by inflammatory stimuli in rat astrocytes: lipopolysaccharide induction through p38 mitogen-activated protein kinase pathway
    J Hur
    Graduate School of East West Medical Science and Research Institute for Basic Sciences, Kyunghee University, Seoul, South Korea
    FEBS Lett 507:157-62. 2001
    ..Inflammatory induction of caspase-11 in astrocytes may play an important role in both inflammatory responses involving these cells and auto-regulatory apoptosis of activated astrocytes in inflammatory sites...
  26. ncbi request reprint Electroconvulsive shock reduces inositol trisphosphate receptor1 mRNA in rat brain
    H Kim
    Department of Psychiatry, College of Medicine, and Institute for Neuroscience, Seoul National University, Korea
    Mol Cells 12:173-7. 2001
    ..This finding, along with our previous report on the InsP3 3-kinase(A), suggests that ECS regulates the phosphoinositide mediated signaling, which might be related to the therapeutic mechanism of ECS...
  27. ncbi request reprint Methimazole as an antioxidant and immunomodulator in thyroid cells: mechanisms involving interferon-gamma signaling and H(2)O(2) scavenging
    H Kim
    Korea Research Institute of Bioscience and Biotechnology, Yusong, Taejon, Korea
    Mol Pharmacol 60:972-80. 2001
    ..These results may in part explain the antioxidant and immunomodulatory effects of MMI in thyroid cells of Graves' disease patients...
  28. ncbi request reprint Effects of active immunization with inhibin alpha subunit on reproductive characteristics of turkey hens
    J Ahn
    Department of Animal Science, University of Minnesota, St. Paul, Minnesota 55108, USA
    Biol Reprod 65:1594-600. 2001
    ..The data confirm previous reports that VIP immunoneutralization increases egg production in turkey hens and shows for the first time that it also increases FSH beta subunit and LH beta subunit gene expression...
  29. ncbi request reprint The effect of a disrupted yhjQ gene on cellular morphology and cell growth in Escherichia coli
    M K Kim
    Division of Applied Life Science, Gyeongsang National University, Chinju 660 701, Korea
    Appl Microbiol Biotechnol 60:134-8. 2002
    ..These results suggest that the product of yhjQ may affect normal doubling and cellular morphology...
  30. ncbi request reprint Genetic diversity at the major histocompatibility complex (B) and microsatellite loci in three commercial broiler pure lines
    M G Emara
    Department of Animal and Food Sciences, University of Delaware, Newark, 19717, USA
    Poult Sci 81:1609-17. 2002
    ..Analysis of MHC and non-MHC loci suggests that there is still sufficient genetic diversity in the broiler lines to continue the progress toward improved broiler chicken production...
  31. ncbi request reprint Nuclear loss of DNA repair Ku proteins and c-myc expression in apoptosis of cerulein-stimulated pancreatic acinar cells
    J H Yu
    Department of Pharmacology, Brain Korea 21 Project for Medical Science, College of Medicine, Yonsei University, Seoul, 120 752, Korea
    Inflammopharmacology 15:282-7. 2007
    ..Conclusively, nuclear loss of Ku70 and Ku80 may cause the loss of defense against DNA damage and apoptosis in pancreatic acinar cells stimulated with cerulein...
  32. ncbi request reprint DNA repair Ku proteins in gastric cancer cells and pancreatic acinar cells
    H Kim
    Department of Food and Nutrition, Brain Korea 21 Project, College of Human Ecology and Biomolecule Secretion Research Center, Institute of Gastroenterology, College of Medicine, Yonsei University, Seoul, Korea
    Amino Acids 34:195-202. 2008
    ..In addition, nuclear loss of Ku may underlie the mechanism of apoptosis in pancreatic acinar cells after oxidative stress...
  33. pmc Genetic predictors for acute experimental cold and heat pain sensitivity in humans
    H Kim
    J Med Genet 43:e40. 2006
    ..The genetic contribution to pain sensitivity underlies a complex composite of parallel pain pathways, multiple mechanisms, and diverse inter-individual pain experiences and expectations...
  34. ncbi request reprint Neural correlates of rapid spectrotemporal processing in musicians and nonmusicians
    N Gaab
    Department of Psychology, Stanford University, California, USA
    Ann N Y Acad Sci 1060:82-8. 2005
    ..This finding may have important implications for improving language/reading skills, especially in children struggling with dyslexia...
  35. pmc Characterization of the Bacillus subtilis spore morphogenetic coat protein CotO
    D C McPherson
    Department of Microbiology and Immunology, Loyola University Medical Center, 2160 S 1st Ave, Maywood, IL 60153, USA
    J Bacteriol 187:8278-90. 2005
    ..We further speculate that an important role of these proteins is ensuring that polymerization of the outer coat layers occurs in such a manner that contiguous shells, and not unproductive aggregates, are formed...
  36. ncbi request reprint Regulation of osteoclast differentiation by the redox-dependent modulation of nuclear import of transcription factors
    Y J Huh
    Department of Oral Biochemistry and Craniomaxillofacial Reconstructive Science, Dental Research Institute, Seoul National University College of Dentistry, Seoul 110 749, Korea
    Cell Death Differ 13:1138-46. 2006
    ..These findings indicate that redox status decreases during osteoclast differentiation and that this modification directly regulates RANKL-induced osteoclastogenesis...
  37. ncbi request reprint Overexpression of LIM kinase 1 renders resistance to apoptosis in PC12 cells by inhibition of caspase activation
    E Yang
    Department of Microbiology, Brain Korea 21 Project for Medical Science, and Institute for Immunology and Immunological Disease, Yonsei University College of Medicine, Seoul, South Korea
    Cell Mol Neurobiol 24:181-92. 2004
    ..These results suggest that the LIMK1 might allow resistance to apoptosis in PC12 cells by inhibiting JNK activation...
  38. ncbi request reprint rhBMP-2 injected in a calcium phosphate paste (alpha-BSM) accelerates healing in the rabbit ulnar osteotomy model
    R H Li
    Wyeth Research, 200 Cambridge Park Drive, Cambridge, MA 02140, USA
    J Orthop Res 21:997-1004. 2003
    ..These data indicate rhBMP-2 delivered in alpha-BSM accelerated healing in a rabbit ulna osteotomy model compared to BSM and SXCT groups...
  39. ncbi request reprint Genetic markers and their application in poultry breeding
    M G Emara
    Department of Animal and Food Sciences, University of Delaware, Newark, Delaware 19717, USA
    Poult Sci 82:952-7. 2003
    ..Application of SNP to identify disease resistance genes in chickens is of special interest to our laboratory, especially in regards to Marek's disease and coccidiosis...
  40. ncbi request reprint Transgenic mice expressing the betaAPP695SWE mutation: effects on exploratory activity, anxiety, and motor coordination
    R Lalonde
    Faculte de Medecine et de Pharmacie, Universite de Rouen, 22 Boulevard Gambetta, INSERM EMI 9906, IFRMP 23, B√Ętiment de Recherche, Salle 1D18, 76183 Rouen Cedex, France
    Brain Res 977:38-45. 2003
    ..These measures may be added to cognitive dysfunctions as testing ground for Abeta vaccination and other attempts at experimental therapies...
  41. ncbi request reprint Blockade of p38 mitogen-activated protein kinase pathway inhibits interleukin-6 release and expression in primary neonatal cardiomyocytes
    H Chae
    Department of Dental Pharmacology, Wonkwang Dental Research Institute, School of Dentistry, Wonkwang University, Iksan Chonbuk, 570-749, South Korea
    Res Commun Mol Pathol Pharmacol 110:209-28. 2001
    ..This study strongly suggests that these pathways about TNF-alpha/IFN-gamma or LPS/IFN-gamma-activated IL-6 release can be primarily dissociated in primary neonatal cardiomyocytes...
  42. ncbi request reprint Two cases of citrullinaemia presenting with stroke
    J H Choi
    Department of Pediatrics, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea
    J Inherit Metab Dis 29:182-3. 2006
    ..We report two infant cases of citrullinaemia that both initially presented with a stroke and suggest that urea cycle disorders should be included in the differential diagnosis of unexplained stroke during infancy and childhood...
  43. pmc Involvement of the BLT2 receptor in the itch-associated scratching induced by 12-(S)-lipoxygenase products in ICR mice
    H J Kim
    Laboratory of Skin Research AmorePacific Corporation R and D Center, Gyeonggi Do, Korea
    Br J Pharmacol 154:1073-8. 2008
    ....
  44. ncbi request reprint Through induction of juxtaposition and tyrosine kinase activity of Jak1, X-gene product of hepatitis B virus stimulates Ras and the transcriptional activation through AP-1, NF-kappaB, and SRE enhancers
    H Kim
    Division of Molecular Life Science and Center for Cell Signaling Research, Ewha Woman s University, 11 1 Daehyundong, Seoul, Seodaemoongu, 120 750, Korea
    Biochem Biophys Res Commun 286:886-94. 2001
    ..These findings show that previously reported functions of HBx, such as activation of multiple signaling pathways and transcriptional activation are attributable to HBx-mediated Jak1 activation...
  45. ncbi request reprint Necrotic cell death by hydrogen peroxide in immortal DF-1 chicken embryo fibroblast cells expressing deregulated MnSOD and catalase
    H Kim
    Department of Animal Science, University of Minnesota, St. Paul, 55108, USA
    Biochim Biophys Acta 1540:137-46. 2001
    ..Taken together, our observation suggests that the balanced antioxidant function might be important for cell proliferation in response to toxic oxidative damage by hydrogen peroxide...
  46. ncbi request reprint Interstitial fibrosis in mice with overload proteinuria: deficiency of TIMP-1 is not protective
    A A Eddy
    the Children s Hospital and Regional Medical Center, University of Washington, Seattle 98105, USA
    Kidney Int 58:618-28. 2000
    ....
  47. pmc Tissue-specificity, functional characterization and subcellular localization of a rat ubiquitin-specific processing protease, UBP109, whose mRNA expression is developmentally regulated
    K C Park
    Division of Biological Sciences and Research Center for Cell Differentiation, College of Natural Sciences, Seoul National University, Seoul 151 742, Korea
    Biochem J 349:443-53. 2000
    ....
  48. pmc Rat brain expresses an alternatively spliced form of the dihydropyridine-sensitive L-type calcium channel alpha 2 subunit
    H L Kim
    Laboratory of Molecular Biology, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892
    Proc Natl Acad Sci U S A 89:3251-5. 1992
    ....
  49. ncbi request reprint A role for hepatocyte growth factor during early postimplantation growth of the placental lineage in mice
    Y Patel
    Department of Obstetrics and Gynecology, Northwestern University Medical School, Chicago, Illinois 60611, USA
    Biol Reprod 62:904-12. 2000
    ..These data suggest that HGF stimulates the cell division, but not the differentiation, of trophoblast cells during implantation...
  50. ncbi request reprint Sequence of a cDNA encoding mouse F1F0-ATP synthase g subunit
    D Jeon
    Department of Genetic Engineering, College of Agriculture, Chonnam National University, Kwangju, Korea
    Biosci Biotechnol Biochem 63:767-8. 1999
    ..Comparison of the deduced amino acid sequences of mouse ATP synthase g subunit with those of bovine species showed 86% identity. The high levels of ATP synthase g subunit mRNA were detected in heart and uterine tissues...
  51. ncbi request reprint Morphologic investigation of rolling mouse Nagoya (tg(rol)/tg(rol)) cerebellar Purkinje cells: an ataxic mutant, revisited
    I J Rhyu
    Institute of Human Genetics and Department of Anatomy, Korea University College of Medicine, Seoul, South Korea
    Neurosci Lett 266:49-52. 1999
    ..The correlation between the presence of altered Purkinje cell synapses and ataxia in rolling mice warrants further investigation...
  52. ncbi request reprint Increased susceptibility in Hp knockout mice during acute hemolysis
    S K Lim
    Cardiovascular Research Institute, National University Medical Institutes, The National University of Singapore
    Blood 92:1870-7. 1998
    ..This study suggested that a physiologically important role of hemoglobin-haptoglobin complex formation is the amelioration of tissue damages by hemoglobin-driven lipid peroxidation...
  53. ncbi request reprint Up-regulation of uncoupling protein 3 (UCP3) mRNA by exercise training and down-regulation of UCP3 by denervation in skeletal muscles
    N Tsuboyama-Kasaoka
    Division of Clinical Nutrition, National Institute of Health and Nutrition, 1 23 1 Toyama, Tokyo, Shinjuku ku, 162 8636, Japan
    Biochem Biophys Res Commun 247:498-503. 1998
    ..These data indicate that UCP3 may have a role for fine adjustments of energy expenditure and that up-regulation of UCP3 mRNA may be a defense mechanism against extra energy supply to consume extra energy in skeletal muscles...
  54. ncbi request reprint Molecular cloning of a peptidase against N-acetylaspartylglutamate from a rat hippocampal cDNA library
    T Bzdega
    Department of Biology, Georgetown University, Washington, D C 20057 1229, U S A
    J Neurochem 69:2270-7. 1997
    ..Spinal cord yielded an amplification product only with primers for the 5' end of the hippocampal cDNA...
  55. pmc Differential functional significance of AP-1 binding sites in the promoter of the gene encoding mouse tissue inhibitor of metalloproteinases-3
    H Kim
    Gene Regulation Section, Laboratory of Biochemical Physiology, National Cancer Institute, Frederick Cancer Research and Development Center, Frederick, MD 21702, USA
    Biochem J 324:547-53. 1997
    ..In summary, we report here that both AP-1 and non-AP-1 elements contribute to activity, with the non-consensus AP-1 site at -720 showing the greatest functional significance among the AP-1 sites...
  56. ncbi request reprint Detection of mutations in the insulin receptor gene in patients with insulin resistance by analysis of single-stranded conformational polymorphisms
    H Kim
    Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Japan
    Diabetologia 35:261-6. 1992
    ....
  57. ncbi request reprint Isolation and cloning of a voltage-dependent anion channel-like Mr 36,000 polypeptide from mammalian brain
    M H Bureau
    Department of Pharmacology, School of Medicine, University of California, Los Angeles 90024
    J Biol Chem 267:8679-84. 1992
    ..Further studies are needed to determine whether such an association occurs in vivo...
  58. ncbi request reprint Genomic analysis and functional expression of canine dopamine D2 receptor
    H Myeong
    National Creative Research Initiative Center for Behavioral Genetics, Department of Biological Sciences, Korea Advanced Institute of Science and Technology, 305 701, Taejon, South Korea
    Gene 257:99-107. 2000
    ..When the canine DRD2L and DRD2S were heterologously expressed in Xenopus oocytes, both forms activated GIRK1 potassium channels through coupling with G(i) protein. This activation was dose-dependent, demonstrating its ligand specificity...
  59. ncbi request reprint Effect of ginsenosides on voltage-dependent Ca(2+) channel subtypes in bovine chromaffin cells
    S Choi
    National Research Laboratory for the Study of Ginseng Signal Transduction and Department of Physiology, College of Veterinary Medicine Chonnam National University, 500-757, Kwangju, South Korea
    J Ethnopharmacol 74:75-81. 2001
    ..Thus, the selective regulation of voltage-dependent Ca(2+) subtypes by ginsenosides in bovine chromaffin cell could be the cellular basis of antistress effects induced by ginseng...
  60. ncbi request reprint Phenytoin-induced lingual tonsil hyperplasia causing laryngeal obstruction
    W M Ralph
    Department of Otolaryngology-Head and Neck Surgery, Albert Einstein College of Medicine, Bronx, New York, USA
    Ann Otol Rhinol Laryngol 110:790-3. 2001
    ..The findings of histopathologic evaluation were consistent with lymphoid hyperplasia without evidence of malignancy. We also report our operative management and follow-up of this rare condition...
  61. ncbi request reprint The plant flavonoid wogonin suppresses death of activated C6 rat glial cells by inhibiting nitric oxide production
    H Kim
    Department of Herbal Pharmacology, Graduate School of East-West Medical Science, Kyung Hee University, Hoegi-Dong, Tongdaemun-ku, 130-701, Seoul, South Korea
    Neurosci Lett 309:67-71. 2001
    ....
  62. ncbi request reprint Effect of astaxanthin on the hepatotoxicity, lipid peroxidation and antioxidative enzymes in the liver of CCl4-treated rats
    J O Kang
    Department of Food and Nutrition, College of Human Ecology, Seoul National University, Korea
    Methods Find Exp Clin Pharmacol 23:79-84. 2001
    ..These results suggest that astaxanthin protects liver damage induced by CCl4 by inhibiting lipid peroxidation and stimulating the cellular antioxidant system...
  63. ncbi request reprint TIMP-1 deficiency does not attenuate interstitial fibrosis in obstructive nephropathy
    H Kim
    the Children s Hospital and Regional Medical Center, University of Washington, 4800 Sand Point Way NE, Seattle, WA 98105, USA
    J Am Soc Nephrol 12:736-48. 2001
    ....
  64. ncbi request reprint TUCAN, an antiapoptotic caspase-associated recruitment domain family protein overexpressed in cancer
    N Pathan
    Burnham Institute, La Jolla, California 92037, USA
    J Biol Chem 276:32220-9. 2001
    ..Thus, TUCAN represents a new member of the CARD family that selectively suppresses apoptosis induced via the mitochondrial pathway for caspase activation...
  65. ncbi request reprint Dual role of inflammatory stimuli in activation-induced cell death of mouse microglial cells. Initiation of two separate apoptotic pathways via induction of interferon regulatory factor-1 and caspase-11
    J Lee
    Graduate School of East-West Medical Science, Kyunghee University, Seoul 130-701, Korea
    J Biol Chem 276:32956-65. 2001
    ..These results indicated that LPS/IFNgamma not only induced the production of cytotoxic NO through IRF-1 but also initiated the NO-independent apoptotic pathway through the induction of caspase-11 expression...
  66. ncbi request reprint Pyrrolidine dithiocarbamate inhibits serum-induced NF-kappaB activation and induces apoptosis in ROS 17/2.8 osteoblasts
    H Chae
    Department of Dental Pharmacology, School of Dentistry, Wonkwang University, Iksan, Chonbuk, South Korea
    Int Immunopharmacol 1:255-63. 2001
    ..Thus, overall, these results show that PDTC induces apoptosis and suggest that JNK/SAPK and subsequent AP-1 activation may be involved in the apoptotic pathway in ROS 17/2.8 osteoblasts...
  67. ncbi request reprint Gene profile of replicative senescence is different from progeria or elderly donor
    W Y Park
    Department of Biochemistry and Molecular Biology, Seoul National University, Seoul, Korea
    Biochem Biophys Res Commun 282:934-9. 2001
    ..Differential expression pattern of several genes were confirmed by RT-PCR. We suggest that the replicative senescence model might behave differently to other types of aging models due to the distinct gene expression...
  68. ncbi request reprint Gonad-specific expression of two novel chicken complementary DNA isoforms
    H Kim
    Department of Animal Science, University of Minnesota, St Paul, Minnesota 55108, USA
    Biol Reprod 64:1473-80. 2001
    ..These results suggest that the C47L and C47S isoforms might play an important role in the regulation and maintenance of ovarian and testicular functions, respectively, in the chicken...
  69. ncbi request reprint Cytokine-augmented culture of haematopoietic progenitor cells in a novel three-dimensional cell growth matrix
    N Banu
    Cytomatrix, Cell Growth Systems, Woburn, MA 01801, USA
    Cytokine 13:349-58. 2001
    ..These findings demonstrate that a three-dimensional matrix promotes the survival of primitive HPCs in culture and may modulate the in vitro effects of cytokines...
  70. ncbi request reprint Neuroprotective effects of estrogen against beta-amyloid toxicity are mediated by estrogen receptors in cultured neuronal cells
    H Kim
    Brain Disease Research Center, Ajou University School of Medicine, 442-721, Suwon, South Korea
    Neurosci Lett 302:58-62. 2001
    ..Hoechst staining revealed that estrogen protected ERalpha-expressing cells by blocking Abeta-induced apoptosis. These results indicate that estrogen blocks Abeta-induced cell death via ERalpha-dependent pathways...
  71. ncbi request reprint Effects of nicotine on APP secretion and Abeta- or CT(105)-induced toxicity
    J Seo
    Department of Pharmacology, College of Medicine, National Creative Research Initiative Centre for Alzheimer's Proteins and Neuroscience Research Institute, Medical Research Centre, Seoul National University, Seoul, South Korea
    Biol Psychiatry 49:240-7. 2001
    ....
  72. ncbi request reprint The gene for the dihydropyridine-sensitive calcium channel alpha 2 subunit (CCHL2A) maps to the proximal region of mouse chromosome 5
    H Chin
    Laboratory of Molecular Biology, NINDS, National Institute of Health, Bethesda, Maryland 20892
    Genomics 13:1325-7. 1992
    ..This gene, termed Cchl2a, was mapped near the centromeric end of the Chromosome 5 linkage group with gene order: centromere-Pgy-1-Cchl2a-Il-6-Pgm-1...