Su Hyun Jo

Summary

Affiliation: Kangwon National University
Country: Korea

Publications

  1. doi request reprint H(1) antihistamine drug promethazine directly blocks hERG K(+) channel
    Su Hyun Jo
    Department of Physiology, Institute of Bioscience and Biotechnology, Kangwon National University College of Medicine, Chuncheon, Republic of Korea
    Pharmacol Res 60:429-37. 2009
  2. doi request reprint Clomipramine block of the hERG K+ channel: accessibility to F656 and Y652
    Su Hyun Jo
    Department of Physiology, Institute of Bioscience and Biotechnology, Kangwon National University College of Medicine, Chuncheon 200 701, Korea
    Eur J Pharmacol 592:19-25. 2008
  3. doi request reprint Protriptyline block of the human ether-à-go-go-related gene (HERG) K+ channel
    Su Hyun Jo
    Department of Physiology, Institute of Bioscience and Biotechnology, Kangwon National University College of Medicine, Chuncheon 200 701, South Korea
    Life Sci 82:331-40. 2008
  4. doi request reprint Block of hERG K+ channel and prolongation of action potential duration by fluphenazine at submicromolar concentration
    Hee Kyung Hong
    Department of Physiology, Institute of Bioscience and Biotechnology, Kangwon National University School of Medicine, Chuncheon 200 701, South Korea
    Eur J Pharmacol 702:165-73. 2013
  5. ncbi request reprint Effect of azelastine on cardiac repolarization of guinea-pig cardiomyocytes, hERG K⁺ channel, and human L-type and T-type Ca²⁺ channel
    Mi Hyeong Park
    Department of Physiology, Institute of Bioscience and Biotechnology, Kangwon National University College of Medicine, Korea
    J Pharmacol Sci 123:67-77. 2013
  6. ncbi request reprint Chemical modification of the human ether-a-go-go-related gene (HERG) K+ current by the amino-group reagent trinitrobenzene sulfonic acid
    Su Hyun Jo
    Department of Physiology, College of Medicine, Cheju National University, Jeju 690 756, Korea
    Arch Pharm Res 29:310-7. 2006
  7. pmc Inhibition of the human ether-a-go-go-related gene (HERG) K+ channels by Lindera erythrocarpa
    Hee Kyung Hong
    Department of Physiology, Institute of Bioscience and Biotechnology, Kangwon National University College of Medicine, Chuncheon, Korea
    J Korean Med Sci 24:1089-98. 2009
  8. doi request reprint The Ca(2+) channel inhibitor efonidipine decreases voltage-dependent K(+) channel activity in rabbit coronary arterial smooth muscle cells
    Mi Hyeong Park
    Institute of Medical Sciences, Department of Physiology, Kangwon National University School of Medicine, Chuncheon 200 701, South Korea
    Vascul Pharmacol 59:90-5. 2013
  9. ncbi request reprint Maprotiline block of the human ether-a-go-go-related gene (HERG) K+ channel
    Su Hyun Jo
    Department of Physiology, Institute of Bioscience and Biotechnology, Kangwon National University College of Medicine, Chuncheon, Korea
    Arch Pharm Res 30:453-60. 2007
  10. doi request reprint Acute alteration of cardiac ECG, action potential, I(Kr) and the human ether-a-go-go-related gene (hERG) K+ channel by PCB 126 and PCB 77
    Mi Hyeong Park
    Department of Physiology, Institute of Bioscience and Biotechnology, Kangwon National University College of Medicine, Chuncheon 200 701, Republic of Korea
    Toxicol Appl Pharmacol 262:60-9. 2012

Collaborators

  • Han Choe
  • Jing Yu
  • Sungkwon Chung
  • Jin Han
  • Kyong Tai Kim
  • Hongliang Li
  • Eun Bo Shim
  • E G Lakatta
  • Mi Hyeong Park
  • Hee Kyung Hong
  • Se Young Choi
  • Byung Hoon Lee
  • Keimin Lee
  • Bok Hee Choi
  • Seung Ho Lee
  • Won Sun Park
  • Youn Kyoung Son
  • So Young Lee
  • Tae Yong Choi
  • Il Whan Choi
  • Daehyun Chu
  • Sung Jun Jung
  • Moon Doo Kim
  • Veronique Leblais
  • Rui Ping Xiao
  • Jong Ho Lee
  • Norihito Sasaki
  • Seulki Choi
  • Hui Yeon Ko
  • Seung Hyun Lee
  • Hyun Nam
  • Yoon Jung Kim
  • Kyungpyo Park
  • La Mee Choi
  • Gehoon Chung
  • Gene Lee
  • Yurim Park
  • Eunice Sung Durrance
  • Ji Eun Kwon
  • Hyoweon Bang
  • Da Hye Hong
  • Dae Joong Kim
  • Dae hyun Chu
  • Woo Jin Kim
  • Sung Hun Na
  • Kwang Hee Won
  • Haena Lee
  • In Duk Jung
  • Yeong Min Park
  • Nari Kim
  • Jeong Im Sin
  • Seong Woo Choi
  • Won Kyo Jung
  • Jin Won Hyun
  • Weon Jong Yoon
  • Young Ho Kim
  • Eun Sook Yoo
  • Woo Dong Nam
  • Sanghyuck Lee
  • Eunhui Oh
  • Seog Bae Oh
  • Min Seok Kim
  • Young Jin Kim
  • Su Yong Eun
  • Young Sang Koh
  • Khalid Chakir
  • Wang Wang
  • Michael T Crow
  • Jae Boum Youm
  • Ming Zheng
  • Yung E Earm
  • Victor Maltsev
  • Chin O Lee
  • Won Kyung Ho
  • Roberto Bolli
  • Andreas Ohler
  • Yiru Guo
  • BRIAN O'ROURKE
  • Masaharu Akao
  • Mitsushige Murata
  • Eduardo Marban

Detail Information

Publications27

  1. doi request reprint H(1) antihistamine drug promethazine directly blocks hERG K(+) channel
    Su Hyun Jo
    Department of Physiology, Institute of Bioscience and Biotechnology, Kangwon National University College of Medicine, Chuncheon, Republic of Korea
    Pharmacol Res 60:429-37. 2009
    ..These results suggest that promethazine is a blocker of the hERG channels, providing a molecular mechanism for the arrhythmogenic side effects during the clinical administration of promethazine...
  2. doi request reprint Clomipramine block of the hERG K+ channel: accessibility to F656 and Y652
    Su Hyun Jo
    Department of Physiology, Institute of Bioscience and Biotechnology, Kangwon National University College of Medicine, Chuncheon 200 701, Korea
    Eur J Pharmacol 592:19-25. 2008
    ..These results suggest that clomipramine is a blocker of the hERG channels, providing a molecular mechanism for the arrhythmogenic side effects during the clinical administration of clomipramine...
  3. doi request reprint Protriptyline block of the human ether-à-go-go-related gene (HERG) K+ channel
    Su Hyun Jo
    Department of Physiology, Institute of Bioscience and Biotechnology, Kangwon National University College of Medicine, Chuncheon 200 701, South Korea
    Life Sci 82:331-40. 2008
    ..Our findings suggest that inhibition of HERG currents may contribute to the arrhythmogenic side effects of protriptyline...
  4. doi request reprint Block of hERG K+ channel and prolongation of action potential duration by fluphenazine at submicromolar concentration
    Hee Kyung Hong
    Department of Physiology, Institute of Bioscience and Biotechnology, Kangwon National University School of Medicine, Chuncheon 200 701, South Korea
    Eur J Pharmacol 702:165-73. 2013
    ..These results suggest that the antipsychotic drug fluphenazine is a potent blocker of hERG channels, providing a molecular mechanism for the drug-induced arrhythmogenic side effects...
  5. ncbi request reprint Effect of azelastine on cardiac repolarization of guinea-pig cardiomyocytes, hERG K⁺ channel, and human L-type and T-type Ca²⁺ channel
    Mi Hyeong Park
    Department of Physiology, Institute of Bioscience and Biotechnology, Kangwon National University College of Medicine, Korea
    J Pharmacol Sci 123:67-77. 2013
    ..These results suggest that azelastine is a potent blocker of hERG channels rather than I(Ca,L) or I(Ca,T), providing molecular mechanisms for the arrhythmogenic side effects during the clinical administration of azelastine...
  6. ncbi request reprint Chemical modification of the human ether-a-go-go-related gene (HERG) K+ current by the amino-group reagent trinitrobenzene sulfonic acid
    Su Hyun Jo
    Department of Physiology, College of Medicine, Cheju National University, Jeju 690 756, Korea
    Arch Pharm Res 29:310-7. 2006
    ..Our data provide evidence for the presence of essential amino-groups that are associated with the normal functioning of the HERG channel and evidence that these groups modify the blocking effect of external H+ on the current...
  7. pmc Inhibition of the human ether-a-go-go-related gene (HERG) K+ channels by Lindera erythrocarpa
    Hee Kyung Hong
    Department of Physiology, Institute of Bioscience and Biotechnology, Kangwon National University College of Medicine, Chuncheon, Korea
    J Korean Med Sci 24:1089-98. 2009
    ..Our findings suggest that Lindera erythrocarpa, a traditional medicine, blocks HERG channel, which could contribute to its anticancer and cardiac arrhythmogenic effect...
  8. doi request reprint The Ca(2+) channel inhibitor efonidipine decreases voltage-dependent K(+) channel activity in rabbit coronary arterial smooth muscle cells
    Mi Hyeong Park
    Institute of Medical Sciences, Department of Physiology, Kangwon National University School of Medicine, Chuncheon 200 701, South Korea
    Vascul Pharmacol 59:90-5. 2013
    ..We conclude that efonidipine dose-dependently inhibits Kv current in a phosphorylation- and Ca(2+) channel-independent manner. ..
  9. ncbi request reprint Maprotiline block of the human ether-a-go-go-related gene (HERG) K+ channel
    Su Hyun Jo
    Department of Physiology, Institute of Bioscience and Biotechnology, Kangwon National University College of Medicine, Chuncheon, Korea
    Arch Pharm Res 30:453-60. 2007
    ..13 microM at +20 mV. Our findings suggest that the arrhythmogenic side effects of maprotiline are caused by a blockade of HERG and possibly by a blockade of delayed rectifier K+ channel...
  10. doi request reprint Acute alteration of cardiac ECG, action potential, I(Kr) and the human ether-a-go-go-related gene (hERG) K+ channel by PCB 126 and PCB 77
    Mi Hyeong Park
    Department of Physiology, Institute of Bioscience and Biotechnology, Kangwon National University College of Medicine, Chuncheon 200 701, Republic of Korea
    Toxicol Appl Pharmacol 262:60-9. 2012
    ....
  11. pmc Effects of the histamine H(1) receptor antagonist hydroxyzine on hERG K(+) channels and cardiac action potential duration
    Byung Hoon Lee
    Department of Physiology, Institute of Bioscience and Biotechnology, Kangwon National University School of Medicine, Chuncheon 200 701, Korea
    Acta Pharmacol Sin 32:1128-37. 2011
    ..To investigate the effects of hydroxyzine on human ether-a-go-go-related gene (hERG) channels to determine the electrolphysiological basis for its proarrhythmic effects...
  12. doi request reprint Block of the human ether-a-go-go-related gene (hERG) K+ channel by the antidepressant desipramine
    Hee Kyung Hong
    Department of Physiology, Institute of Bioscience and Biotechnology, School of Medicine, Kangwon National University, Hyoja Dong, Chuncheon 200 701, Republic of Korea
    Biochem Biophys Res Commun 394:536-41. 2010
    ..These results suggest that desipramine is a blocker of the hERG channels, providing a molecular mechanism for the arrhythmogenic side effects during the clinical administration of desipramine...
  13. doi request reprint Cortisone and hydrocortisone inhibit human Kv1.3 activity in a non-genomic manner
    Jing Yu
    Department of Physiology, Institute of Bioscience and Biotechnology, BK21 Plus Graduate Program, Kangwon National University College of Medicine, Hyoja Dong, Chuncheon, 200 701, Republic of Korea
    Naunyn Schmiedebergs Arch Pharmacol 388:653-61. 2015
    ..These results suggest that cortisone and hydrocortisone inhibit Kv1.3 currents via a non-genomic mechanism, providing a mechanism for the immunosuppressive effects of glucocorticoids. ..
  14. ncbi request reprint A novel hypothesis for the binding mode of HERG channel blockers
    Han Choe
    Department of Physiology, University of Ulsan College of Medicine, 388 1 PoongNap dong Songpa goo, Seoul 138 736, South Korea
    Biochem Biophys Res Commun 344:72-8. 2006
    ....
  15. pmc Non-Dioxin-Like Polychlorinated Biphenyls Inhibit G-Protein Coupled Receptor-Mediated Ca2+ Signaling by Blocking Store-Operated Ca2+ Entry
    Se Young Choi
    Department of Physiology, Dental Research Institute, Seoul National University School of Dentistry, Seoul, Korea
    PLoS ONE 11:e0150921. 2016
    ..These results imply that one of the molecular mechanism by which NDL-PCBs cause neurobehavioral disturbances involves NDL-PCB-mediated inhibition of SOCE, thereby interfering with GPCR-mediated Ca2+ signaling. ..
  16. doi request reprint Human salivary gland cells express bradykinin receptors that modulate the expression of proinflammatory cytokines
    Keimin Lee
    Department of Physiology, Dental Research Institute, Seoul National University School of Dentistry, Seoul, Korea
    Eur J Oral Sci . 2016
    ..These data suggest that bradykinin receptors are involved in Ca2+ signaling in human submandibular gland cells and serve a unique role, which is separate from that of other salivary gland G protein-coupled receptors...
  17. doi request reprint Inhibitory effects of cortisone and hydrocortisone on human Kv1.5 channel currents
    Jing Yu
    Department of Physiology, Institute of Bioscience and Biotechnology, BK21 Plus Graduate Program, Kangwon National University School of Medicine, Chuncheon 200 701, Republic of Korea
    Eur J Pharmacol 746:158-66. 2015
    ..These results show that cortisone and hydrocortisone inhibited Kv1.5 channel currents differently, and that Kv1.5 channels were more sensitive to hydrocortisone than to cortisone. ..
  18. doi request reprint Melatonin inhibits voltage-sensitive Ca(2+) channel-mediated neurotransmitter release
    Tae Yong Choi
    Department of Physiology, Dental Research Institute, Seoul National University School of Dentistry, Seoul 110 749, Republic of Korea
    Brain Res 1557:34-42. 2014
    ..These results show that melatonin inhibits neurotransmitter release through the blocking of voltage-sensitive Ca(2+) channels and suggest a possible mechanism for the antiepileptic effect of melatonin. ..
  19. pmc Effects of somatostatin on the responses of rostrally projecting spinal dorsal horn neurons to noxious stimuli in cats
    Sung Jun Jung
    Department of Physiology, Kangwon National University College of Medicine, Chunchon 200 701, Korea
    Korean J Physiol Pharmacol 12:253-8. 2008
    ..These findings suggest that SOM has a dual effect on the activities of RPSDH neurons; that is, facilitation and inhibition, depending on the modality of pain signaled through them and its action site...
  20. doi request reprint The inhibitory effect of Ca2+-activated K+ channel activator, BMS on L-type Ca2+ channels in rat ventricular myocytes
    Youn Kyoung Son
    Department of Physiology, Kangwon National University School of Medicine, Chuncheon, 200 701, Republic of Korea
    Life Sci 89:331-6. 2011
    ..We investigated the effects of BMS-204352 (BMS), a big-conductance calcium-activated potassium (BK(Ca)) channel activator, on L-type Ca(2+) channels...
  21. pmc Block of HERG k channel by classic histamine h(1) receptor antagonist chlorpheniramine
    Hee Kyung Hong
    Department of Physiology, Institute of Bioscience and Biotechnology, Kangwon National University College of Medicine, Chuncheon 200 701, Korea
    Korean J Physiol Pharmacol 13:215-20. 2009
    ..These results suggest that the H(1) antihistamine, chlorpheniramine is a blocker of the hERG channels, providing a molecular mechanism for the drug-induced arrhythmogenic side effects...
  22. ncbi request reprint Block of HERG human K(+) channel and IKr of guinea pig cardiomyocytes by chlorpromazine
    So Young Lee
    Department of Life Science, Pohang University of Science and Technology, Pohang, Korea
    J Cardiovasc Pharmacol 43:706-14. 2004
    ..Our findings suggest that the arrhythmogenic side effect of chlorpromazine is caused by blockade of HERG and rapid component of delayed rectifier K current rather than by blockade of the slow component...
  23. ncbi request reprint Inhibition of human ether-a-go-go-related gene K+ channel and IKr of guinea pig cardiomyocytes by antipsychotic drug trifluoperazine
    Se Young Choi
    Department of Physiology, Seoul National University College of Dentistry, Yeongun Dong
    J Pharmacol Exp Ther 313:888-95. 2005
    ..Our findings suggest the arrhythmogenic side effect of trifluoperazine is caused by a blockade of HERG and the rapid component of the delayed rectifier K(+) current rather than by the blockade of the slow component...
  24. pmc Blockade of HERG human K+ channels and IKr of guinea-pig cardiomyocytes by the antipsychotic drug clozapine
    So Young Lee
    Department of Life Science, Pohang University of Science and Technology, Korea
    Br J Pharmacol 148:499-509. 2006
    ..Our findings collectively suggest that blockade of HERG currents and I(Kr), but not I(Ks), may contribute to the arrhythmogenic side effects of clozapine...
  25. ncbi request reprint Blockade of HERG human K+ channel and IKr of guinea pig cardiomyocytes by prochlorperazine
    Moon Doo Kim
    Department of Psychiatry, Cheju National University College of Medicine, Jeju, Korea
    Eur J Pharmacol 544:82-90. 2006
    ..Our findings suggest that the arrhythmogenic side effects of prochlorperazine are caused by a blockade of HERG and the rapid component of the delayed rectifier K+ current rather than by a blockade of the slow component...
  26. ncbi request reprint Phosphatidylinositol 3-kinase offsets cAMP-mediated positive inotropic effect via inhibiting Ca2+ influx in cardiomyocytes
    Veronique Leblais
    Laboratory of Cardiovascular Science, Gerontology Research Center, National Institute on Aging, NIH, Baltimore, MD 21224, USA
    Circ Res 95:1183-90. 2004
    ....
  27. pmc MCC-134, a single pharmacophore, opens surface ATP-sensitive potassium channels, blocks mitochondrial ATP-sensitive potassium channels, and suppresses preconditioning
    Norihito Sasaki
    Laboratory of the Institute of Molecular Cardiobiology, Johns Hopkins University, Baltimore, MD 21205, USA
    Circulation 107:1183-8. 2003
    ..A mixed agonist/blocker with differential effects on the two channel types would help to clarify the role of K(ATP) channels in cardioprotection...