Pil Seok Chae

Summary

Affiliation: Hanyang University
Country: Korea

Publications

  1. ncbi request reprint Tandem neopentyl glycol maltosides (TNMs) for membrane protein stabilisation
    Hyoung Eun Bae
    Department of Bionanotechnology, Hanyang University, Ansan, 15588, Korea
    Chem Commun (Camb) 52:12104-12107. 2016
  2. pmc Maltose neopentyl glycol-3 (MNG-3) analogues for membrane protein study
    Kyung Ho Cho
    Department of Bionanotechnology, Hanyang University, Ansan, 426 791, Korea
    Analyst 140:3157-63. 2015
  3. doi request reprint New ganglio-tripod amphiphiles (TPAs) for membrane protein solubilization and stabilization: implications for detergent structure-property relationships
    Pil Seok Chae
    Department of Bionanotechnology, Hanyang University, Ansan, 426 791, Korea
    Org Biomol Chem 12:8480-7. 2014
  4. doi request reprint Adamantane-based amphiphiles (ADAs) for membrane protein study: importance of a detergent hydrophobic group in membrane protein solubilisation
    Pil Seok Chae
    Department of Bionanotechnology, Hanyang University, Ansan, 426 791, Korea
    Chem Commun (Camb) 50:12300-3. 2014
  5. pmc Novel tripod amphiphiles for membrane protein analysis
    Pil Seok Chae
    Department of Bionano Engineering, Hanyang University Ansan, 426 791 Korea, Fax 81 31 436 8146
    Chemistry 19:15645-51. 2013
  6. pmc Hydrophobic variations of N-oxide amphiphiles for membrane protein manipulation: importance of non-hydrocarbon groups in the hydrophobic portion
    Pil Seok Chae
    Department of Bionano Engineering, Hanyang University Ansan, 426 791 Korea, Fax 81 31 436 8146
    Chem Asian J 9:110-6. 2014
  7. pmc Hydrophobic variants of ganglio-tripod amphiphiles for membrane protein manipulation
    Pil Seok Chae
    Department of Bionano Engineering, Hanyang University, Ansan 426 791, Republic of Korea Electronic address
    Biochim Biophys Acta 1838:278-86. 2014
  8. pmc Glucose-neopentyl glycol (GNG) amphiphiles for membrane protein study
    Pil Seok Chae
    Department of Bionano Engineering, Hanyang University, Ansan, 426 791, Korea
    Chem Commun (Camb) 49:2287-9. 2013
  9. pmc Carbohydrate-containing Triton X-100 analogues for membrane protein solubilization and stabilization
    Pil Seok Chae
    Department of Bionano Engineering, Hanyang University, Ansan, 426 791, Korea
    Mol Biosyst 9:626-9. 2013
  10. pmc A new class of amphiphiles bearing rigid hydrophobic groups for solubilization and stabilization of membrane proteins
    Pil Seok Chae
    Department of Bionano Engineering, Hanyang University, Ansan, 426 791 Korea
    Chemistry 18:9485-90. 2012

Collaborators

  • Bernadette Byrne
  • Lan Guan
  • Hazrat Hussain
  • Kyung Ho Cho
  • Claus J Loland
  • Jonas S Mortensen
  • Yang Du
  • Brian K Kobilka
  • Hyoung Eun Bae
  • Parameswaran Hariharan
  • Muhammad Ehsan
  • Aiman Sadaf
  • Elena Tikhonova
  • Kamil Gotfryd
  • Jin Woong Kim
  • Orquídea Ribeiro
  • Nicola J Scull
  • Aram Byun
  • Juyeon Go
  • Eun Seon Jeong
  • Georgios Skiniotis
  • Jeffrey Tarrasch
  • Orquidea de Castro Ribeiro
  • Anne K Nielsen
  • Stefano Capaldi
  • Kelsey Markham
  • Sang Woo Han
  • Ho Jin Lee
  • Hyeong Seok Shin
  • Jennifer Thomas
  • Jongwon Shim
  • Bohyun Kim
  • Mohd Husri
  • Anowarul Amin
  • Han Am Son
  • Kyoung Ho Park
  • Min Kyung Kim
  • Sechan Kay
  • Samuel H Gellman
  • Manabendra Das

Detail Information

Publications22

  1. ncbi request reprint Tandem neopentyl glycol maltosides (TNMs) for membrane protein stabilisation
    Hyoung Eun Bae
    Department of Bionanotechnology, Hanyang University, Ansan, 15588, Korea
    Chem Commun (Camb) 52:12104-12107. 2016
    ..The best detergent varied depending on the target, but TNM-C12L and TNM-C11S were notable for their ability to confer increased membrane protein stability compared to DDM. These agents have potential for use in membrane protein research...
  2. pmc Maltose neopentyl glycol-3 (MNG-3) analogues for membrane protein study
    Kyung Ho Cho
    Department of Bionanotechnology, Hanyang University, Ansan, 426 791, Korea
    Analyst 140:3157-63. 2015
    ..This set of MNGs represents viable alternatives to currently available detergents for handling MPs, and can be also used as tools to estimate MP sensitivity to denaturation and aggregation...
  3. doi request reprint New ganglio-tripod amphiphiles (TPAs) for membrane protein solubilization and stabilization: implications for detergent structure-property relationships
    Pil Seok Chae
    Department of Bionanotechnology, Hanyang University, Ansan, 426 791, Korea
    Org Biomol Chem 12:8480-7. 2014
    ..The current study combined with previous TPA studies enabled us to elaborate on a few detergent structure-property relationships that could provide useful guidelines for novel amphiphile design. ..
  4. doi request reprint Adamantane-based amphiphiles (ADAs) for membrane protein study: importance of a detergent hydrophobic group in membrane protein solubilisation
    Pil Seok Chae
    Department of Bionanotechnology, Hanyang University, Ansan, 426 791, Korea
    Chem Commun (Camb) 50:12300-3. 2014
    ..These agents were superior to conventional detergents, especially in terms of the membrane protein solubilisation efficiency, implying a new detergent structure-property relationship. ..
  5. pmc Novel tripod amphiphiles for membrane protein analysis
    Pil Seok Chae
    Department of Bionano Engineering, Hanyang University Ansan, 426 791 Korea, Fax 81 31 436 8146
    Chemistry 19:15645-51. 2013
    ....
  6. pmc Hydrophobic variations of N-oxide amphiphiles for membrane protein manipulation: importance of non-hydrocarbon groups in the hydrophobic portion
    Pil Seok Chae
    Department of Bionano Engineering, Hanyang University Ansan, 426 791 Korea, Fax 81 31 436 8146
    Chem Asian J 9:110-6. 2014
    ....
  7. pmc Hydrophobic variants of ganglio-tripod amphiphiles for membrane protein manipulation
    Pil Seok Chae
    Department of Bionano Engineering, Hanyang University, Ansan 426 791, Republic of Korea Electronic address
    Biochim Biophys Acta 1838:278-86. 2014
    ..Their efficacy rivals benchmark detergents heavily used today, such as n-dodecyl-β-d-maltoside. ..
  8. pmc Glucose-neopentyl glycol (GNG) amphiphiles for membrane protein study
    Pil Seok Chae
    Department of Bionano Engineering, Hanyang University, Ansan, 426 791, Korea
    Chem Commun (Camb) 49:2287-9. 2013
    ..These amphiphiles display promising behavior for membrane proteins, as demonstrated recently by the high resolution structure of a sodium-pumping pyrophosphatase reported by Kellosalo et al. (Science, 2012, 337, 473)...
  9. pmc Carbohydrate-containing Triton X-100 analogues for membrane protein solubilization and stabilization
    Pil Seok Chae
    Department of Bionano Engineering, Hanyang University, Ansan, 426 791, Korea
    Mol Biosyst 9:626-9. 2013
    ..This study introduces a class of easy-to-synthesize amphiphiles, which are designated CGT (Chae's Glyco-Triton) detergents. Some of the agents are well suited for membrane protein solubilization and stabilization...
  10. pmc A new class of amphiphiles bearing rigid hydrophobic groups for solubilization and stabilization of membrane proteins
    Pil Seok Chae
    Department of Bionano Engineering, Hanyang University, Ansan, 426 791 Korea
    Chemistry 18:9485-90. 2012
    ..The results show that the new amphiphile, "glyco-diosgenin" (GDN; see figure), confers enhanced stability to a variety of membrane proteins in solution relative to popular conventional detergents, such as dodecylmaltoside (DDM)...
  11. pmc Highly Branched Pentasaccharide-Bearing Amphiphiles for Membrane Protein Studies
    Muhammad Ehsan
    Department of Bionanotechnology, Hanyang University, Ansan, 426 791, Korea
    J Am Chem Soc 138:3789-96. 2016
    ....
  12. doi request reprint Accessible Mannitol-Based Amphiphiles (MNAs) for Membrane Protein Solubilisation and Stabilisation
    Hazrat Hussain
    Department of Bionanotechnology, Hanyang University, Ansan, 426 791, Korea
    Chemistry 22:7068-73. 2016
    ..The ease of preparation together with the enhanced membrane protein stabilisation efficacy demonstrates the value of these agents for future membrane protein research. ..
  13. pmc A Class of Rigid Linker-bearing Glucosides for Membrane Protein Structural Study
    Aiman Sadaf
    Department of Bionanotechnology, Hanyang University, Ansan, 426 791 Korea
    Chem Sci 7:1933-1939. 2016
    ..Because of straightforward synthesis of the novel agents and their favourable effects on a range of membrane proteins, these agents should be of wide applicability to membrane protein science...
  14. doi request reprint Mesitylene-Cored Glucoside Amphiphiles (MGAs) for Membrane Protein Studies: Importance of Alkyl Chain Density in Detergent Efficacy
    Kyung Ho Cho
    Department of Bionanotechnology, Hanyang University, Ansan, 15588, Korea
    Chemistry 22:18833-18839. 2016
    ..Thus, this study not only describes new glucoside agents with potential for membrane protein research, but also introduces a new detergent design principle for future development...
  15. doi request reprint Isomeric Detergent Comparison for Membrane Protein Stability: Importance of Inter-Alkyl-Chain Distance and Alkyl Chain Length
    Kyung Ho Cho
    Department of Bionanotechnology, Hanyang University, 55 Hanyangdaehak ro, Sangnok gu, Ansan, 15588, Korea
    Chembiochem 17:2334-2339. 2016
    ..In addition, differences in inter-alkyl-chain distance between the isomers influence the ability of the detergents to stabilise membrane proteins...
  16. pmc Novel Xylene-Linked Maltoside Amphiphiles (XMAs) for Membrane Protein Stabilisation
    Kyung Ho Cho
    Department of Bionanotechnology, Hanyang University, Ansan, 426 791 Republic of Korea
    Chemistry 21:10008-13. 2015
    ....
  17. doi request reprint Deoxycholate-Based Glycosides (DCGs) for Membrane Protein Stabilisation
    Hyoung Eun Bae
    Department of Bionanotechnology, Hanyang University, Hanyangdaehak ro, Ansan, 426 791 Korea
    Chembiochem 16:1454-9. 2015
    ..Given their excellent properties, these agents should have significant potential for membrane protein studies. ..
  18. doi request reprint Hemifluorinated maltose-neopentyl glycol (HF-MNG) amphiphiles for membrane protein stabilisation
    Kyung Ho Cho
    Department of Bionano Engineering, Hanyang University, 55 Hanyangdaehak ro, Sangnok gu, Ansan, 426 791, Korea
    Chembiochem 14:452-5. 2013
    ..Such amphiphiles are attractive as tools for membrane science because of their ease of preparation and structure variation...
  19. doi request reprint Improved glucose-neopentyl glycol (GNG) amphiphiles for membrane protein solubilization and stabilization
    Kyung Ho Cho
    Department of Bionanotechnology, Hanyang University, Ansan, 426 791 Korea, Fax 81 31 436 8146
    Chem Asian J 9:632-8. 2014
    ..Furthermore, a detergent structure-property relationship that could serve as a useful guideline for the design of novel amphiphiles is discussed. ..
  20. doi request reprint Amphipathic agents for membrane protein study
    Aiman Sadaf
    Department of Bionanotechnology, Hanyang University, Ansan, South Korea
    Methods Enzymol 557:57-94. 2015
    ....
  21. doi request reprint One-pot microfluidic fabrication of graphene oxide-patched hollow hydrogel microcapsules with remarkable shell impermeability
    Aram Byun
    Department of BioNano Technology, Hanyang University, Ansan 426 791, Republic of Korea
    Chem Commun (Camb) 51:12756-9. 2015
    ..We demonstrate that patching a small amount of graphene oxide at the interfaces remarkably prevents the leakage of small molecules through the shell. ..
  22. doi request reprint Fabrication of monodisperse liposomes-in-microgel hybrid microparticles in capillary-based microfluidic devices
    Eun Seon Jeong
    Department of BioNano Technology, Hanyang University, Ansan, Gyeonggi do 426 791, Republic of Korea
    Colloids Surf B Biointerfaces 123:339-44. 2014
    ....