Soon B Hwang

Summary

Affiliation: Hallym University
Country: Korea

Publications

  1. pmc Nonstructural 5A protein of hepatitis C virus interacts with pyruvate carboxylase and modulates viral propagation
    Seung Ae Yim
    National Research Laboratory of Hepatitis C Virus, Ilsong Institute of Life Science, Hallym University, Anyang, Korea
    PLoS ONE 8:e68170. 2013
  2. pmc Saponin inhibits hepatitis C virus propagation by up-regulating suppressor of cytokine signaling 2
    Jihye Lee
    National Research Laboratory of Hepatitis C Virus, Ilsong Institute of Life Science, Hallym University, Anyang, Korea
    PLoS ONE 7:e39366. 2012
  3. ncbi request reprint Nonstructural 5A protein activates beta-catenin signaling cascades: implication of hepatitis C virus-induced liver pathogenesis
    Chul Yong Park
    National Research Laboratory of Hepatitis C Virus and Ilsong Institute of Life Science, Hallym University, Dongan Gu, Anyang, Republic of Korea
    J Hepatol 51:853-64. 2009
  4. pmc Hepatitis C virus nonstructural 5B protein regulates tumor necrosis factor alpha signaling through effects on cellular IkappaB kinase
    Soo Ho Choi
    Ilsong Institute of Life Science, Hallym University, 1 Ockcheon dong, Chuncheon 200 702, South Korea
    Mol Cell Biol 26:3048-59. 2006
  5. doi request reprint Hepatitis delta virus large antigen sensitizes to TNF-alpha-induced NF-kappaB signaling
    Chul Yong Park
    Ilsong Institute of Life Science, Hallym University, Anyang 431 060, Korea
    Mol Cells 28:49-55. 2009
  6. pmc Modulation of mitogen-activated protein kinase-activated protein kinase 3 by hepatitis C virus core protein
    Huong T T Ngo
    National Research Laboratory of Hepatitis C Virus and Ilsong Institute of Life Science, Hallym University, Anyang, South Korea
    J Virol 87:5718-31. 2013
  7. doi request reprint Modulation of interferon signaling by hepatitis C virus non-structural 5A protein: implication of genotypic difference in interferon treatment
    Sang Min Kang
    National Research Laboratory of Hepatitis C Virus, Ilsong Institute of Life Science, Hallym University, Dongan Gu, Anyang, Republic of Korea
    FEBS Lett 584:4069-76. 2010
  8. ncbi request reprint Large hepatitis delta antigen modulates transforming growth factor-beta signaling cascades: implication of hepatitis delta virus-induced liver fibrosis
    Soo Ho Choi
    Ilsong Institute of Life Science, Hallym University, 1605 4 Gwanyang dong, Dongan Gu, Anyang 431 060, Korea
    Gastroenterology 132:343-57. 2007
  9. doi request reprint Hepatitis C virus non-structural 5B protein interacts with cyclin A2 and regulates viral propagation
    Long V Pham
    National Research Laboratory of Hepatitis C Virus, Ilsong Institute of Life Science, Hallym University, Anyang 431 060, Republic of Korea
    J Hepatol 57:960-6. 2012
  10. doi request reprint c-Fos regulates hepatitis C virus propagation
    Sang Min Kang
    National Research Laboratory of Hepatitis C Virus, Ilsong Institute of Life Science, Hallym University, Anyang, Republic of Korea
    FEBS Lett 585:3236-44. 2011

Collaborators

  • Takaji Wakita
  • Michael M C Lai
  • Sook Hyang Jeong
  • Hoguen Kim
  • Soo Young Lee
  • Kang Yell Choi
  • Yun Sook Lim
  • Sang Min Kang
  • Soo Ho Choi
  • Chul Yong Park
  • Huong T T Ngo
  • Huong T L Tran
  • Seung Ae Yim
  • Long V Pham
  • Kyu Jin Park
  • Byung Yoon Ahn
  • Jong Wook Kim
  • Jihye Lee
  • Seri Lim
  • Seung Jae Won
  • Guhung Jung
  • Dong Hwa Choi
  • Jung Min Park
  • Saehong Min
  • Kidong Son
  • Eun Mee Park
  • Han Sol Lee
  • Ye Jin Shin
  • Soo Je Park
  • Gun Hee Lee
  • Hyun Jeong Jun
  • Ju Il Kang
  • Jae Hun Cheong
  • Sang Heun Oh
  • Hyun Jung Jun
  • So Yeon Kim
  • Se Won Yie

Detail Information

Publications18

  1. pmc Nonstructural 5A protein of hepatitis C virus interacts with pyruvate carboxylase and modulates viral propagation
    Seung Ae Yim
    National Research Laboratory of Hepatitis C Virus, Ilsong Institute of Life Science, Hallym University, Anyang, Korea
    PLoS ONE 8:e68170. 2013
    ..Silencing of PC promoted fatty acid synthase (FAS) expression level. These data suggest HCV may modulate PC via NS5A protein for its own propagation. ..
  2. pmc Saponin inhibits hepatitis C virus propagation by up-regulating suppressor of cytokine signaling 2
    Jihye Lee
    National Research Laboratory of Hepatitis C Virus, Ilsong Institute of Life Science, Hallym University, Anyang, Korea
    PLoS ONE 7:e39366. 2012
    ..These data imply that saponin inhibits HCV replication via SOCS2 signaling pathway. These findings suggest that saponin may be a potent therapeutic agent for HCV patients...
  3. ncbi request reprint Nonstructural 5A protein activates beta-catenin signaling cascades: implication of hepatitis C virus-induced liver pathogenesis
    Chul Yong Park
    National Research Laboratory of Hepatitis C Virus and Ilsong Institute of Life Science, Hallym University, Dongan Gu, Anyang, Republic of Korea
    J Hepatol 51:853-64. 2009
    ..Wnt/beta-catenin signaling has also been involved in tumorigenesis. To elucidate the molecular mechanism of HCV pathogenesis, we examined the potential effects of HCV NS5A protein on Wnt/beta-catenin signal transduction cascades...
  4. pmc Hepatitis C virus nonstructural 5B protein regulates tumor necrosis factor alpha signaling through effects on cellular IkappaB kinase
    Soo Ho Choi
    Ilsong Institute of Life Science, Hallym University, 1 Ockcheon dong, Chuncheon 200 702, South Korea
    Mol Cell Biol 26:3048-59. 2006
    ..These data suggest that NS5B protein modulates TNF-alpha signaling pathways and may contribute to HCV pathogenesis...
  5. doi request reprint Hepatitis delta virus large antigen sensitizes to TNF-alpha-induced NF-kappaB signaling
    Chul Yong Park
    Ilsong Institute of Life Science, Hallym University, Anyang 431 060, Korea
    Mol Cells 28:49-55. 2009
    ..Finally, we demonstrated that LHDAg augmented the COX-2 expression level in Huh7 cells. These data suggest that LHDAg modulates NF-kappaB signaling pathway and may contribute to HDV pathogenesis...
  6. pmc Modulation of mitogen-activated protein kinase-activated protein kinase 3 by hepatitis C virus core protein
    Huong T T Ngo
    National Research Laboratory of Hepatitis C Virus and Ilsong Institute of Life Science, Hallym University, Anyang, South Korea
    J Virol 87:5718-31. 2013
    ..We showed that MAPKAPK3 increased HCV IRES-mediated translation and MAPKAPK3-dependent HCV IRES activity was further increased by core protein. These data suggest that HCV core may modulate MAPKAPK3 to facilitate its own propagation...
  7. doi request reprint Modulation of interferon signaling by hepatitis C virus non-structural 5A protein: implication of genotypic difference in interferon treatment
    Sang Min Kang
    National Research Laboratory of Hepatitis C Virus, Ilsong Institute of Life Science, Hallym University, Dongan Gu, Anyang, Republic of Korea
    FEBS Lett 584:4069-76. 2010
    ..These data imply that some other host factor may be involved in genotypic differences of IFN antagonism in HCV patients...
  8. ncbi request reprint Large hepatitis delta antigen modulates transforming growth factor-beta signaling cascades: implication of hepatitis delta virus-induced liver fibrosis
    Soo Ho Choi
    Ilsong Institute of Life Science, Hallym University, 1605 4 Gwanyang dong, Dongan Gu, Anyang 431 060, Korea
    Gastroenterology 132:343-57. 2007
    ....
  9. doi request reprint Hepatitis C virus non-structural 5B protein interacts with cyclin A2 and regulates viral propagation
    Long V Pham
    National Research Laboratory of Hepatitis C Virus, Ilsong Institute of Life Science, Hallym University, Anyang 431 060, Republic of Korea
    J Hepatol 57:960-6. 2012
    ..In the current study, we have selected and characterized the gene encoding Cyclin A2 (CycA2). Deregulation of CycA2 has been implicated in many types of cancers, including hepatocellular carcinoma...
  10. doi request reprint c-Fos regulates hepatitis C virus propagation
    Sang Min Kang
    National Research Laboratory of Hepatitis C Virus, Ilsong Institute of Life Science, Hallym University, Anyang, Republic of Korea
    FEBS Lett 585:3236-44. 2011
    ..These data suggest that c-Fos acts as a positive regulator of HCV propagation and may contribute to HCV-associated pathogenesis...
  11. pmc Peptidyl-prolyl isomerase Pin1 is a cellular factor required for hepatitis C virus propagation
    Yun Sook Lim
    National Research Laboratory of Hepatitis C Virus, Ilsong Institute of Life Science, Hallym University, 1605 4 Gwanyang dong, Dongan Gu, Anyang 431 060, South Korea
    J Virol 85:8777-88. 2011
    ..These data indicate that Pin1 modulates HCV propagation and may contribute to HCV-induced liver pathogenesis...
  12. ncbi request reprint C-terminal domain of hepatitis C virus core protein is essential for secretion
    Soo Ho Choi
    Ilsong Institute of Life Science, Hallym University, 1 Ockcheon dong, Chuncheon 200 702, South Korea
    World J Gastroenterol 11:3887-92. 2005
    ..We have previously demonstrated that hepatitis C virus (HCV) core protein is efficiently released into the culture medium in insect cells. The objective of this study is to characterize the HCV core secretion in insect cells...
  13. doi request reprint Characterization of monoclonal antibodies against the nonstructural 5A protein of hepatitis C virus
    Sang Min Kang
    National Research Laboratory of Hepatitis C Virus, Ilsong Institute of Life Science, Hallym University, 1605 4 Gwanyang dong, Dongan Gu, Anyang 431 060, Korea
    Arch Virol 154:843-51. 2009
    ....
  14. pmc Hepatitis C virus NS5A protein interacts with phosphatidylinositol 4-kinase type IIIalpha and regulates viral propagation
    Yun Sook Lim
    National Research Laboratory of Hepatitis C Virus, Ilsong Institute of Life Science, Hallym University, Anyang, Korea
    J Biol Chem 286:11290-8. 2011
    ..NS5A may recruit PI4KIIIα to the HCV RNA replication complex. These data suggest that PI4KIIIα is an essential host factor that supports HCV proliferation and therefore PI4KIIIα may be a legitimate target for anti-HCV therapy...
  15. pmc Hepatitis C virus nonstructural 4B protein modulates sterol regulatory element-binding protein signaling via the AKT pathway
    Chul Yong Park
    National Research Laboratory of Hepatitis C Virus and Ilsong Institute of Life Science, Hallym University, Anyang 431 060, Korea
    J Biol Chem 284:9237-46. 2009
    ..These results strongly suggest that NS4B may play an important role in HCV-associated liver pathogenesis by modulating the SREBP signaling pathway...
  16. doi request reprint Establishment of interferon alpha-resistant hepatitis C virus using cell culture system
    Huong T L Tran
    National Research Laboratory of Hepatitis C Virus, Ilsong Institute of Life Science, Hallym University, Anyang, Republic of Korea
    FEBS Lett 585:409-13. 2011
    ..These data suggest that four amino acid substitutions in NS5A are involved in IFNα resistance and thus this newly established HCV may be a useful tool for elucidating the molecular mechanisms of IFNα resistance in HCV patients...
  17. ncbi request reprint Modulation of the transforming growth factor-beta signal transduction pathway by hepatitis C virus nonstructural 5A protein
    Soo Ho Choi
    Ilsong Institute of Life Science, Hallym University, 1 Ockcheon dong, Chuncheon 200 702, Korea
    J Biol Chem 281:7468-78. 2006
    ..These results indicate that HCV NS5A modulates TGF-beta signaling through interaction with TbetaR-I and that NS5A may be an important risk factor in HCV-associated liver pathogenesis...
  18. ncbi request reprint 1Hepatitis C virus NS5A protein modulates c-Jun N-terminal kinase through interaction with tumor necrosis factor receptor-associated factor 2
    Kyu Jin Park
    Ilsong Institute of Life Science, Hallym University, Chuncheon 200 702, Korea
    J Biol Chem 278:30711-8. 2003
    ..These results indicate that HCV NS5A protein modulates TNF signaling of the host cells and may play a role in HCV pathogenesis...