Young Sam Keum

Summary

Affiliation: Dongguk University
Country: Korea

Publications

  1. doi request reprint Molecular and chemical regulation of the Keap1-Nrf2 signaling pathway
    Young Sam Keum
    College of Pharmacy, Dongguk University, 813 4 Siksa dong, Goyang, Gyeonggi do 410 820, Korea
    Molecules 19:10074-89. 2014
  2. doi request reprint Regulation of the Keap1/Nrf2 system by chemopreventive sulforaphane: implications of posttranslational modifications
    Young Sam Keum
    Department of Biochemistry, College of Pharmacy, Dongguk University, 813 Siksa dong, Goyang, Kyunggi Do, 410 773, Republic of Korea
    Ann N Y Acad Sci 1229:184-9. 2011
  3. doi request reprint Discovery of α-mangostin as a novel competitive inhibitor against mutant isocitrate dehydrogenase-1
    Hyo Joon Kim
    College of Pharmacy, Dongguk University, Goyang, Gyeonggi do 410 820, Republic of Korea
    Bioorg Med Chem Lett 25:5625-31. 2015
  4. doi request reprint Sulforaphane suppresses LPS-induced or TPA-induced downregulation of PDCD4 in RAW 264.7 cells
    Jong Ho Cho
    College of Pharmacy, Dongguk University, 814 9 Siksa dong, Goyang, Gyeonggi Do, 410 820, Korea
    Phytother Res 28:1606-11. 2014
  5. doi request reprint Sulforaphane inhibition of TPA-mediated PDCD4 downregulation contributes to suppression of c-Jun and induction of p21-dependent Nrf2 expression
    Jong Ho Cho
    College of Pharmacy, Dongguk University, Goyang, Gyeonggi Do, 410 773, Republic of Korea
    Eur J Pharmacol 741:247-53. 2014
  6. doi request reprint Identification of 4'-O-β-D-glucosyl-5-O-methylvisamminol as a novel epigenetic suppressor of histone H3 phosphorylation at Ser10 and its interaction with 14-3-3ε
    Jong Su Kang
    College of Pharmacy, Dongguk University, Goyang, Gyeonggi do 410 773, Republic of Korea
    Bioorg Med Chem Lett 24:4763-7. 2014
  7. pmc Mechanisms of Nrf2/Keap1-dependent phase II cytoprotective and detoxifying gene expression and potential cellular targets of chemopreventive isothiocyanates
    Biswa Nath Das
    College of Pharmacy, Dongguk University, Goyang, Gyeonggi do 410 820, Republic of Korea
    Oxid Med Cell Longev 2013:839409. 2013
  8. pmc Isocitrate dehydrogenase mutations: new opportunities for translational research
    Young Sam Keum
    College of Pharmacy, Dongguk University, Goyang 410 820, Korea
    BMB Rep 48:266-70. 2015

Collaborators

  • Jong Ho Cho
  • Young Woo Kim
  • Bu Young Choi
  • Hyo Joon Kim
  • Kyeong Lee
  • Jong Su Kang
  • Biswa Nath Das
  • Xiang Fei
  • Seok Cheol Cho
  • Hee Chul Ahn
  • Seung Yong Seo
  • Young Won Chin

Detail Information

Publications10

  1. doi request reprint Molecular and chemical regulation of the Keap1-Nrf2 signaling pathway
    Young Sam Keum
    College of Pharmacy, Dongguk University, 813 4 Siksa dong, Goyang, Gyeonggi do 410 820, Korea
    Molecules 19:10074-89. 2014
    ..Finally, we illustrate the current status in the development of Nrf2 chemical activators and inhibitors for the use of potential chemopreventive agents and chemotherapeutic adjuvants, respectively. ..
  2. doi request reprint Regulation of the Keap1/Nrf2 system by chemopreventive sulforaphane: implications of posttranslational modifications
    Young Sam Keum
    Department of Biochemistry, College of Pharmacy, Dongguk University, 813 Siksa dong, Goyang, Kyunggi Do, 410 773, Republic of Korea
    Ann N Y Acad Sci 1229:184-9. 2011
    ....
  3. doi request reprint Discovery of α-mangostin as a novel competitive inhibitor against mutant isocitrate dehydrogenase-1
    Hyo Joon Kim
    College of Pharmacy, Dongguk University, Goyang, Gyeonggi do 410 820, Republic of Korea
    Bioorg Med Chem Lett 25:5625-31. 2015
    ..Collectively, we provide evidence that α-mangostin selectively inhibits IDH1-R132H. ..
  4. doi request reprint Sulforaphane suppresses LPS-induced or TPA-induced downregulation of PDCD4 in RAW 264.7 cells
    Jong Ho Cho
    College of Pharmacy, Dongguk University, 814 9 Siksa dong, Goyang, Gyeonggi Do, 410 820, Korea
    Phytother Res 28:1606-11. 2014
    ..7 cells. We propose that sulforaphane suppression of PDCD4 downregulation serves as a novel molecular mechanism to control proliferation in response to pro-inflammatory signals...
  5. doi request reprint Sulforaphane inhibition of TPA-mediated PDCD4 downregulation contributes to suppression of c-Jun and induction of p21-dependent Nrf2 expression
    Jong Ho Cho
    College of Pharmacy, Dongguk University, Goyang, Gyeonggi Do, 410 773, Republic of Korea
    Eur J Pharmacol 741:247-53. 2014
    ..Collectively, our study illustrates that attenuating the rate of PDCD4 proteolysis and Pdcd4 mRNA degradation serves as a novel anti-inflammatory and cytoprotective mechanism of sulforaphane. ..
  6. doi request reprint Identification of 4'-O-β-D-glucosyl-5-O-methylvisamminol as a novel epigenetic suppressor of histone H3 phosphorylation at Ser10 and its interaction with 14-3-3ε
    Jong Su Kang
    College of Pharmacy, Dongguk University, Goyang, Gyeonggi do 410 773, Republic of Korea
    Bioorg Med Chem Lett 24:4763-7. 2014
    ....
  7. pmc Mechanisms of Nrf2/Keap1-dependent phase II cytoprotective and detoxifying gene expression and potential cellular targets of chemopreventive isothiocyanates
    Biswa Nath Das
    College of Pharmacy, Dongguk University, Goyang, Gyeonggi do 410 820, Republic of Korea
    Oxid Med Cell Longev 2013:839409. 2013
    ..Finally, we discuss the posttranslational modifications of Keap1 and nucleocytoplasmic trafficking of Nrf2 in response to electrophiles and oxidants...
  8. pmc Isocitrate dehydrogenase mutations: new opportunities for translational research
    Young Sam Keum
    College of Pharmacy, Dongguk University, Goyang 410 820, Korea
    BMB Rep 48:266-70. 2015
    ..The present review article briefly discusses the important findings that highlight the molecular mechanisms of IDH1/2 mutations in cancer and provides a current status for development of selective mutant IDH1/2 chemical inhibitors...