Kwadwo A Koram

Summary

Publications

  1. pmc Therapeutic efficacy of artemether-lumefantrine combination in the treatment of uncomplicated malaria among children under five years of age in three ecological zones in Ghana
    Benjamin Abuaku
    Epidemiology Department, Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, P, O, Box LG581, Legon, Ghana
    Malar J 11:388. 2012
  2. pmc Seeking consent to genetic and genomic research in a rural Ghanaian setting: a qualitative study of the MalariaGEN experience
    Paulina Tindana
    The Ethox Centre, Department of Public Health, University of Oxford, Old Road Campus, Headington, Oxford, OX3 7LF, United Kingdom
    BMC Med Ethics 13:15. 2012
  3. pmc A tuberculin skin test survey among Ghanaian school children
    Kennedy Kwasi Addo
    Bacteriology Department, Noguchi Memorial Institute for Medical Research, Legon, Ghana
    BMC Public Health 10:35. 2010
  4. ncbi request reprint Malaria vaccine development: an endemic country perspective
    Kwadwo A Koram
    Department of Epidemiology, Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, Legon, Ghana
    Hum Vaccin 6:12-6. 2010
  5. ncbi request reprint Antibodies to Plasmodium falciparum antigens and the risk of clinical malaria in endemic populations
    Kwadwo A Koram
    Department of Epidemiology, Noguchi Memorial Institute for Medical Research, University of Ghana, PO Box LG581, Legon, Ghana
    Expert Rev Anti Infect Ther 9:987-91. 2011
  6. pmc Effectiveness of combined intermittent preventive treatment for children and timely home treatment for malaria control
    Collins K Ahorlu
    Noguchi Memorial Institute for Medical Research, University of Ghana, Box LG581, Legon, Ghana
    Malar J 8:292. 2009
  7. pmc Two-year evaluation of Intermittent Preventive Treatment for Children (IPTc) combined with timely home treatment for malaria control in Ghana
    Collins K Ahorlu
    Noguchi Memorial Institute for Medical Research, University of Ghana, Box LG581, Legon, Ghana
    Malar J 10:127. 2011
  8. pmc Surveillance of molecular markers of Plasmodium falciparum resistance to sulphadoxine-pyrimethamine 5 years after the change of malaria treatment policy in Ghana
    Nancy O Duah
    Noguchi Memorial Institute for Medical Research, Legon, Accra, Ghana
    Am J Trop Med Hyg 87:996-1003. 2012
  9. pmc Haplotype analyses of haemoglobin C and haemoglobin S and the dynamics of the evolutionary response to malaria in Kassena-Nankana District of Ghana
    Anita Ghansah
    Noguchi Memorial Institute for Medical Research, University of Ghana, Accra, Ghana
    PLoS ONE 7:e34565. 2012
  10. pmc Antibody levels to multiple malaria vaccine candidate antigens in relation to clinical malaria episodes in children in the Kasena-Nankana district of Northern Ghana
    Daniel Dodoo
    Department of Immunology, Noguchi Memorial Institute for Medical Research, University of Ghana, Accra, Ghana
    Malar J 10:108. 2011

Collaborators

Detail Information

Publications22

  1. pmc Therapeutic efficacy of artemether-lumefantrine combination in the treatment of uncomplicated malaria among children under five years of age in three ecological zones in Ghana
    Benjamin Abuaku
    Epidemiology Department, Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, P, O, Box LG581, Legon, Ghana
    Malar J 11:388. 2012
    ..In this regard, the therapeutic efficacy of AL was monitored from September 2010 to April 2011 in four sentinel sites representing the three main ecological zones of the country...
  2. pmc Seeking consent to genetic and genomic research in a rural Ghanaian setting: a qualitative study of the MalariaGEN experience
    Paulina Tindana
    The Ethox Centre, Department of Public Health, University of Oxford, Old Road Campus, Headington, Oxford, OX3 7LF, United Kingdom
    BMC Med Ethics 13:15. 2012
    ..This study sought to identify issues arising in practice during the enrollment of paediatric cases with severe malaria and matched healthy controls into the MalariaGEN study...
  3. pmc A tuberculin skin test survey among Ghanaian school children
    Kennedy Kwasi Addo
    Bacteriology Department, Noguchi Memorial Institute for Medical Research, Legon, Ghana
    BMC Public Health 10:35. 2010
    ..The primary objective of this study was therefore to determine the prevalence of tuberculin skin sensitivity in Ghanaian school children aged 6-10 years in 8 out of 10 regions of Ghana between 2004 and 2006...
  4. ncbi request reprint Malaria vaccine development: an endemic country perspective
    Kwadwo A Koram
    Department of Epidemiology, Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, Legon, Ghana
    Hum Vaccin 6:12-6. 2010
    ..These and other challenges related to the development and deployment of an effective malaria vaccine especially as they concern endemic countries are discussed...
  5. ncbi request reprint Antibodies to Plasmodium falciparum antigens and the risk of clinical malaria in endemic populations
    Kwadwo A Koram
    Department of Epidemiology, Noguchi Memorial Institute for Medical Research, University of Ghana, PO Box LG581, Legon, Ghana
    Expert Rev Anti Infect Ther 9:987-91. 2011
    ..Their interesting finding of the effect of prior exposure on the protection provided against symptomatic malaria and the importance of the results in the immuno-epidemiological studies are discussed in this article...
  6. pmc Effectiveness of combined intermittent preventive treatment for children and timely home treatment for malaria control
    Collins K Ahorlu
    Noguchi Memorial Institute for Medical Research, University of Ghana, Box LG581, Legon, Ghana
    Malar J 8:292. 2009
    ....
  7. pmc Two-year evaluation of Intermittent Preventive Treatment for Children (IPTc) combined with timely home treatment for malaria control in Ghana
    Collins K Ahorlu
    Noguchi Memorial Institute for Medical Research, University of Ghana, Box LG581, Legon, Ghana
    Malar J 10:127. 2011
    ..This paper reports persistence of reduced parasitaemia two years into the intervention. The baseline and year-one-evaluation findings were published earlier...
  8. pmc Surveillance of molecular markers of Plasmodium falciparum resistance to sulphadoxine-pyrimethamine 5 years after the change of malaria treatment policy in Ghana
    Nancy O Duah
    Noguchi Memorial Institute for Medical Research, Legon, Accra, Ghana
    Am J Trop Med Hyg 87:996-1003. 2012
    ..001, respectively). For dhps double mutant G437 + E540 the prevalence was low (1.12%) caused by the very low prevalence of E540. Our findings show the wide use of SP in Ghana and therefore its use for IPTp needs to be closely monitored...
  9. pmc Haplotype analyses of haemoglobin C and haemoglobin S and the dynamics of the evolutionary response to malaria in Kassena-Nankana District of Ghana
    Anita Ghansah
    Noguchi Memorial Institute for Medical Research, University of Ghana, Accra, Ghana
    PLoS ONE 7:e34565. 2012
    ..Here we use haplotypic signatures of selection to investigate the evolutionary history of the malaria-protective alleles HbS and HbC in the Kassena-Nankana District (KND) of Ghana...
  10. pmc Antibody levels to multiple malaria vaccine candidate antigens in relation to clinical malaria episodes in children in the Kasena-Nankana district of Northern Ghana
    Daniel Dodoo
    Department of Immunology, Noguchi Memorial Institute for Medical Research, University of Ghana, Accra, Ghana
    Malar J 10:108. 2011
    ..The present study was done in under six year old children to identify malaria antigens which induce antibodies that correlate with protection from Plasmodium falciparum malaria...
  11. pmc Measuring naturally acquired ex vivo IFN-γ responses to Plasmodium falciparum cell-traversal protein for ookinetes and sporozoites (CelTOS) in Ghanaian adults
    Dorothy Anum
    Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Ghana
    Malar J 14:20. 2015
    ..The aim of this study was to ascertain whether such CelTOS-specific recall responses are also induced in individuals with natural exposure to Plasmodium falciparum...
  12. pmc Measuring naturally acquired immune responses to candidate malaria vaccine antigens in Ghanaian adults
    Daniel Dodoo
    Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Ghana
    Malar J 10:168. 2011
    ..Assessing T cell responses is especially challenging, given genetic restriction, low responses observed in endemic areas, their variability over time, potential suppression by parasitaemia and the intrinsic variability of the assays...
  13. ncbi request reprint HLA-DRB1*04 allele is associated with severe malaria in northern Ghana
    Awo D Osafo-Addo
    Department of Epidemiology, Noguchi Memorial Institute for Medical Research, Accra, Ghana
    Am J Trop Med Hyg 78:251-5. 2008
    ..4%) and Nankam (4.7%), and the OR for the association between DRB1*04 and severe malaria was similar in both ethnic groups. These findings are consistent with results from Gabon suggesting that DRB1*04 is a risk factor for severe malaria...
  14. ncbi request reprint Socio-cultural determinants of treatment delay for childhood malaria in southern Ghana
    Collins K Ahorlu
    Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Ghana
    Trop Med Int Health 11:1022-31. 2006
    ..Effects on health seeking of illness-related experience and meaning are complex, and explaining their role may strengthen interventions for childhood malaria...
  15. pmc Antimalarial drug use among caregivers in Ghana
    Benjamin K Abuaku
    Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Ghana
    Afr Health Sci 4:171-7. 2004
    ..This study provides information on some of the reasons underlying chloroquine treatment failure in the country...
  16. ncbi request reprint Comparative efficacy of antimalarial drugs including ACTs in the treatment of uncomplicated malaria among children under 5 years in Ghana
    Kwadwo A Koram
    Epidemiology Department, Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Ghana
    Acta Trop 95:194-203. 2005
    ..The findings are in agreement with current recommendations for using artemisinin-based combinations for treating uncomplicated malaria in areas of high CHQ failure such as Ghana...
  17. pmc Anti-sporozoite antibodies as alternative markers for malaria transmission intensity estimation
    Kwadwo A Kusi
    Department of Immunology, Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, Legon, Ghana
    Malar J 13:103. 2014
    ..The aim of this study was to develop transmission estimation models based on the seroprevalence of antibodies to two P. falciparum sporozoite antigens (CSP, CelTOS) and compare with models based on the classical blood stage antigen AMA1...
  18. ncbi request reprint Seasonal profiles of malaria infection, anaemia, and bednet use among age groups and communities in northern Ghana
    Kwadwo A Koram
    Noguchi Memorial Institute for Medical Research, Legon, Accra, Ghana
    Trop Med Int Health 8:793-802. 2003
    ..There was a significantly lower risk of parasitaemia among infants [odds ratio (OR) 6-8] and young children (OR 3-4) living in the central, more urbanized sector of the study area...
  19. pmc Increased pfmdr1 gene copy number and the decline in pfcrt and pfmdr1 resistance alleles in Ghanaian Plasmodium falciparum isolates after the change of anti-malarial drug treatment policy
    Nancy O Duah
    Epidemiology Department, Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, PO Box LG581, Legon, Ghana
    Malar J 12:377. 2013
    ....
  20. ncbi request reprint Clinical case definitions and malaria vaccine efficacy
    William O Rogers
    Noguchi Memorial Institute for Medical Research, University of Ghana, Legon
    J Infect Dis 193:467-73. 2006
    ..We suggest that clinical case definitions of malaria that incorporate a threshold parasitemia are arbitrary and do not yield stable estimates of vaccine trial end points...
  21. ncbi request reprint Mutations in Plasmodium falciparum chloroquine resistance transporter and multidrug resistance genes, and treatment outcomes in Ghanaian children with uncomplicated malaria
    Nancy O Duah
    Noguchi Memorial Institute for Medical Research, University of Ghana, P O Box LG581, Legon, Ghana
    J Trop Pediatr 53:27-31. 2007
    ..872 and a p-value = 0.027. All parasite isolates from samples taken at recrudescence from patients with chloroquine treatment failures were found to have both Pfcrt and Pfmdr mutations...
  22. pmc Community concepts of malaria-related illness with and without convulsions in southern Ghana
    Collins K Ahorlu
    Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Ghana
    Malar J 4:47. 2005
    ..Inasmuch as the presence or absence of convulsions reportedly affects timely help-seeking for malaria, a local comparison of these conditions is needed to inform malaria control...