Janet K Kern

Summary

Publications

  1. ncbi request reprint Evidence of parallels between mercury intoxication and the brain pathology in autism
    Janet K Kern
    Institute of Chronic Illnesses, Inc, Silver Spring, MD, USA
    Acta Neurobiol Exp (Wars) 72:113-53. 2012
  2. ncbi request reprint Prospective trial of equine-assisted activities in autism spectrum disorder
    Janet K Kern
    Research Department, Autism Treatment Center, Dallas, Texas, USA
    Altern Ther Health Med 17:14-20. 2011
  3. doi request reprint Toxicity biomarkers in autism spectrum disorder: a blinded study of urinary porphyrins
    Janet K Kern
    Research Department, Genetics Consultants of Dallas ASD Centers, LLC, 408 N Allen Dr, Allen, TX 75013, USA
    Pediatr Int 53:147-53. 2011
  4. doi request reprint The relationship between mercury and autism: A comprehensive review and discussion
    Janet K Kern
    Institute of Chronic Illnesses, Inc, 14 Redgate Court, Silver Spring, MD, 20905 USA Council for Nutritional and Environmental Medicine, Mo i Rana, Norway CoMeD, Inc, 14 Redgate Court, Silver Spring, MD, 20905 USA Electronic address
    J Trace Elem Med Biol 37:8-24. 2016
  5. ncbi request reprint Systematic Assessment of Research on Autism Spectrum Disorder and Mercury Reveals Conflicts of Interest and the Need for Transparency in Autism Research
    Janet K Kern
    Institute of Chronic Illnesses, Inc, 14 Redgate Court, Silver Spring, MD, 20905, USA
    Sci Eng Ethics . 2015
  6. doi request reprint Are ASD and ADHD a Continuum? A Comparison of Pathophysiological Similarities Between the Disorders
    Janet K Kern
    Institute of Chronic Illnesses, Inc, Silver Spring, MD, USA University of Texas Southwestern Medical Center at Dallas, TX, USA
    J Atten Disord 19:805-27. 2015
  7. pmc New science challenges old notion that mercury dental amalgam is safe
    Kristin G Homme
    International Academy of Oral Medicine and Toxicology, ChampionsGate, FL, 33896, USA
    Biometals 27:19-24. 2014
  8. pmc Evidence of neurodegeneration in autism spectrum disorder
    Janet K Kern
    Institute of Chronic Illnesses, Incorporation, Silver Spring, MD, USA
    Transl Neurodegener 2:17. 2013
  9. doi request reprint Handgrip strength in autism spectrum disorder compared with controls
    Janet K Kern
    Institute of Chronic Illnesses, Inc, Silver Spring, Maryland, USA
    J Strength Cond Res 27:2277-81. 2013
  10. pmc Thimerosal exposure and the role of sulfation chemistry and thiol availability in autism
    Janet K Kern
    Institute of Chronic Illnesses, Inc, Silver Spring, MD 20905, USA
    Int J Environ Res Public Health 10:3771-800. 2013

Collaborators

Detail Information

Publications47

  1. ncbi request reprint Evidence of parallels between mercury intoxication and the brain pathology in autism
    Janet K Kern
    Institute of Chronic Illnesses, Inc, Silver Spring, MD, USA
    Acta Neurobiol Exp (Wars) 72:113-53. 2012
    ....
  2. ncbi request reprint Prospective trial of equine-assisted activities in autism spectrum disorder
    Janet K Kern
    Research Department, Autism Treatment Center, Dallas, Texas, USA
    Altern Ther Health Med 17:14-20. 2011
    ..Anecdotal reports and some studies suggest that equine-assisted activities may be beneficial in autism spectrum disorders (ASD)...
  3. doi request reprint Toxicity biomarkers in autism spectrum disorder: a blinded study of urinary porphyrins
    Janet K Kern
    Research Department, Genetics Consultants of Dallas ASD Centers, LLC, 408 N Allen Dr, Allen, TX 75013, USA
    Pediatr Int 53:147-53. 2011
    ..However, these initial studies were criticized because the controls were not age- and gender-matched to the children diagnosed with an ASD...
  4. doi request reprint The relationship between mercury and autism: A comprehensive review and discussion
    Janet K Kern
    Institute of Chronic Illnesses, Inc, 14 Redgate Court, Silver Spring, MD, 20905 USA Council for Nutritional and Environmental Medicine, Mo i Rana, Norway CoMeD, Inc, 14 Redgate Court, Silver Spring, MD, 20905 USA Electronic address
    J Trace Elem Med Biol 37:8-24. 2016
    ..Of these studies, the vast majority (74%) suggest that mercury is a risk factor for ASD, revealing both direct and indirect effects. The preponderance of the evidence indicates that mercury exposure is causal and/or contributory in ASD. ..
  5. ncbi request reprint Systematic Assessment of Research on Autism Spectrum Disorder and Mercury Reveals Conflicts of Interest and the Need for Transparency in Autism Research
    Janet K Kern
    Institute of Chronic Illnesses, Inc, 14 Redgate Court, Silver Spring, MD, 20905, USA
    Sci Eng Ethics . 2015
    ..However, among studies without public health and/or industry affiliation, only 19 % find no relationship between Hg and ASD. The discrepancy in these results suggests a bias indicative of a conflict of interest...
  6. doi request reprint Are ASD and ADHD a Continuum? A Comparison of Pathophysiological Similarities Between the Disorders
    Janet K Kern
    Institute of Chronic Illnesses, Inc, Silver Spring, MD, USA University of Texas Southwestern Medical Center at Dallas, TX, USA
    J Atten Disord 19:805-27. 2015
    ..The objective of this study was to review and compare the similarities between autism spectrum disorder (ASD) and ADHD with regard to symptomatology, neurological deficits, metabolic and endocrine-related conditions, and brain pathology...
  7. pmc New science challenges old notion that mercury dental amalgam is safe
    Kristin G Homme
    International Academy of Oral Medicine and Toxicology, ChampionsGate, FL, 33896, USA
    Biometals 27:19-24. 2014
    ..Throughout the world, efforts are underway to phase down or eliminate the use of mercury dental amalgam. ..
  8. pmc Evidence of neurodegeneration in autism spectrum disorder
    Janet K Kern
    Institute of Chronic Illnesses, Incorporation, Silver Spring, MD, USA
    Transl Neurodegener 2:17. 2013
    ....
  9. doi request reprint Handgrip strength in autism spectrum disorder compared with controls
    Janet K Kern
    Institute of Chronic Illnesses, Inc, Silver Spring, Maryland, USA
    J Strength Cond Res 27:2277-81. 2013
    ..The present study provides support for the use of handgrip strength as a tool for the assessment of targeted treatment in ASD...
  10. pmc Thimerosal exposure and the role of sulfation chemistry and thiol availability in autism
    Janet K Kern
    Institute of Chronic Illnesses, Inc, Silver Spring, MD 20905, USA
    Int J Environ Res Public Health 10:3771-800. 2013
    ....
  11. doi request reprint A biomarker of mercury body-burden correlated with diagnostic domain specific clinical symptoms of autism spectrum disorder
    Janet K Kern
    Autism Treatment Center, Dallas, TX, USA
    Biometals 23:1043-51. 2010
    ..The results show an association between the apparent level of mercury toxicity as measured by recognized urinary porphyrin biomarkers of mercury toxicity and the magnitude of the specific hallmark features of autism as assessed by ATEC...
  12. ncbi request reprint Sensory correlations in autism
    Janet K Kern
    University of Texas, Southwestern Medical Center, Dallas, TX 75390, USA
    Autism 11:123-34. 2007
    ....
  13. doi request reprint A prospective study of transsulfuration biomarkers in autistic disorders
    David A Geier
    Institute of Chronic Illnesses, Inc, Silver Spring, MD, USA
    Neurochem Res 34:386-93. 2009
    ..Patients diagnosed with ASDs should be routinely tested to evaluate transsulfuration metabolites, and potential treatment protocols should be evaluated to potentially correct the transsulfuration abnormalities observed...
  14. doi request reprint Biomarkers of environmental toxicity and susceptibility in autism
    David A Geier
    Institute of Chronic Illnesses, Inc, Silver Spring, Maryland, USA
    J Neurol Sci 280:101-8. 2009
    ..The transsulfuration abnormalities observed among study participants indicate that mercury intoxication was associated with increased oxidative stress and decreased detoxification capacity...
  15. ncbi request reprint Sulfhydryl-reactive metals in autism
    Janet K Kern
    Department of Psychiatry, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9119, USA
    J Toxicol Environ Health A 70:715-21. 2007
    ..The evidence from our study supports the notion that children with autism may have trouble excreting these metals, resulting in a higher body burden that may contribute to symptoms of autism...
  16. ncbi request reprint Thimerosal as discrimination: vaccine disparity in the UN Minamata Convention on mercury
    Lisa K Sykes
    CoMeD, Inc, Silver Spring, MD United States
    Indian J Med Ethics 11:206-18. 2014
    ..This disparity must now be evaluated urgently as a potential form of institutionalised discrimination. ..
  17. pmc Hair toxic metal concentrations and autism spectrum disorder severity in young children
    David A Geier
    Institute of Chronic Illnesses, Silver Spring, MD 20905, USA
    Int J Environ Res Public Health 9:4486-97. 2012
    ....
  18. doi request reprint A prospective blinded evaluation of urinary porphyrins verses the clinical severity of autism spectrum disorders
    David A Geier
    Institute of Chronic Illnesses, Inc, Silver Spring, Maryland, USA
    J Toxicol Environ Health A 72:1585-91. 2009
    ..Since urinary porphyrin testing is clinically available, relatively inexpensive, and noninvasive, it may be used to help suggest whether heavy metal toxicity is associated with ASD...
  19. pmc A clinical trial of glutathione supplementation in autism spectrum disorders
    Janet K Kern
    Genetic Consultants of Dallas, Allen, TX, USA
    Med Sci Monit 17:CR677-82. 2011
    ..The purpose of this study was to examine the use of two commonly used glutathione supplements in subjects diagnosed with an ASD to determine their efficacy in increasing blood glutathione levels in subjects diagnosed with an ASD...
  20. ncbi request reprint Evidence supporting a link between dental amalgams and chronic illness, fatigue, depression, anxiety, and suicide
    Janet K Kern
    Institute of Chronic Illnesses, Inc, Silver Spring, MD, USA
    Neuro Endocrinol Lett 35:537-52. 2014
    ..Thus, consideration of Hg toxicity may be central to the effective clinical investigation of many chronic illnesses, particularly those involving fatigue and depression...
  21. ncbi request reprint The biological basis of autism spectrum disorders: Understanding causation and treatment by clinical geneticists
    David A Geier
    The Institute of Chronic Illnesses, Inc, Silver Spring, Maryland, USA
    Acta Neurobiol Exp (Wars) 70:209-26. 2010
    ..Finally, the clinical geneticist has a wealth of biomarkers to evaluate and treat patients diagnosed with an ASD...
  22. doi request reprint A significant relationship between mercury exposure from dental amalgams and urinary porphyrins: a further assessment of the Casa Pia children's dental amalgam trial
    David A Geier
    Institute of Chronic Illnesses, Inc, Silver Spring, MD, USA
    Biometals 24:215-24. 2011
    ....
  23. pmc Barriers to implementation of a computerized decision support system for depression: an observational report on lessons learned in "real world" clinical settings
    Madhukar H Trivedi
    Mood Disorders Research Program and Clinic, Department of Psychiatry, University of Texas Southwestern Medical Center at Dallas, TX, USA
    BMC Med Inform Decis Mak 9:6. 2009
    ....
  24. doi request reprint A longitudinal cohort study of the relationship between Thimerosal-containing hepatitis B vaccination and specific delays in development in the United States: Assessment of attributable risk and lifetime care costs
    David A Geier
    Institute of Chronic Illnesses, Inc, Silver Spring, MD, USA
    J Epidemiol Glob Health 6:105-18. 2016
    ..5μg organic Hg from T-HBVs administered within the first 6months of life. The resulting lifetime costs to the United States may exceed $1 trillion. ..
  25. pmc A dose-response relationship between organic mercury exposure from thimerosal-containing vaccines and neurodevelopmental disorders
    David A Geier
    Institute of Chronic Illnesses, Inc, 14 Redgate Ct, Silver Spring, MD 20905, USA
    Int J Environ Res Public Health 11:9156-70. 2014
    ....
  26. pmc A two-phase study evaluating the relationship between Thimerosal-containing vaccine administration and the risk for an autism spectrum disorder diagnosis in the United States
    David A Geier
    The Institute of Chronic Illnesses Inc, 14 Redgate Ct, Silver Spring, MD, USA
    Transl Neurodegener 2:25. 2013
    ..55% Hg by weight) in childhood vaccines by conducting a two-phased (hypothesis generating/hypothesis testing) study with documented exposure to varying levels of Thimerosal from vaccinations...
  27. doi request reprint Shared Brain Connectivity Issues, Symptoms, and Comorbidities in Autism Spectrum Disorder, Attention Deficit/Hyperactivity Disorder, and Tourette Syndrome
    Janet K Kern
    1 Institute of Chronic Illnesses, Inc, Silver Spring, Maryland
    Brain Connect 5:321-35. 2015
    ..In addition, this review examines the role and issue of axonal injury and regeneration in order to better understand the neuropathophysiological interplay between short- and long-range axons in connectivity issues. ..
  28. doi request reprint Thimerosal: clinical, epidemiologic and biochemical studies
    David A Geier
    Institute of Chronic Illnesses, Inc, 14 Redgate Ct, Silver Spring, MD 20905, USA Electronic address
    Clin Chim Acta 444:212-20. 2015
    ..Concerns have been voiced about its use because it is toxic to human cells. Although it is banned in several countries, it continues to be added to some vaccines in the United States and many vaccines in the developing world...
  29. ncbi request reprint An evaluation of the role and treatment of elevated male hormones in autism spectrum disorders
    David A Geier
    The Institute of Chronic Illnesses, Inc, Silver Spring, MD, USA
    Acta Neurobiol Exp (Wars) 72:1-17. 2012
    ....
  30. pmc A prospective double-blind, randomized clinical trial of levocarnitine to treat autism spectrum disorders
    David A Geier
    The Institute of Chronic Illnesses, Inc, Silver Spring, MD, USA
    Med Sci Monit 17:PI15-23. 2011
    ..L-carnitine was proposed as a potential treatment for patients diagnosed with an autism spectrum disorder to improve mitochondrial dysfunction, but no prior randomized controlled trials have been conducted...
  31. ncbi request reprint Blood mercury levels in autism spectrum disorder: Is there a threshold level?
    David A Geier
    Institute of Chronic Illnesses, Inc, Silver Spring, MD, USA
    Acta Neurobiol Exp (Wars) 70:177-86. 2010
    ..4). The weight of scientific evidence supports Hg as a causal factor in subjects diagnosed with an ASD...
  32. pmc Thimerosal-Preserved Hepatitis B Vaccine and Hyperkinetic Syndrome of Childhood
    David A Geier
    Institute of Chronic Illnesses, Inc, Silver Spring, MD 20905, USA
    Brain Sci 6:. 2016
    ..43; 95% CI = 1.28-1.59); and within the first six months (odds ratio = 4.51; 95% CI = 3.04-6.71) than controls. (4) CONCLUSION: The results indicate that increasing organic-Hg exposure from TCVs heightens the risk of a HKSoC diagnosis. ..
  33. pmc Thimerosal-containing Hepatitis B Vaccine Exposure is Highly Associated with Childhood Obesity: A Case-control Study Using the Vaccine Safety Datalink
    David A Geier
    Department of Research, Institute of Chronic Illnesses Inc, MD, USA Department of Research, CoMeD, Inc, Silver Spring, MD, USA
    N Am J Med Sci 8:297-306. 2016
    ..Obesity among children and adolescents in the United States has tripled since 1980, and has become a major public health concern...
  34. pmc A case-control study evaluating the relationship between thimerosal-containing haemophilus influenzae type b vaccine administration and the risk for a pervasive developmental disorder diagnosis in the United States
    David A Geier
    The Institute of Chronic Illnesses, Inc, 14 Redgate Ct, Silver Spring, MD, 20905, USA
    Biol Trace Elem Res 163:28-38. 2015
    ....
  35. ncbi request reprint Evidence of toxicity, oxidative stress, and neuronal insult in autism
    Janet K Kern
    Department of Psychiatry, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9119, USA
    J Toxicol Environ Health B Crit Rev 9:485-99. 2006
    ..Finally, the article discusses what may be happening over the course of development and the multiple factors that may interplay and make these children more vulnerable to toxicity, oxidative stress, and neuronal insult...
  36. ncbi request reprint A prospective study of prenatal mercury exposure from maternal dental amalgams and autism severity
    David A Geier
    Institute of Chronic Illnesses, Inc, Silver Spring, Maryland, USA
    Acta Neurobiol Exp (Wars) 69:189-97. 2009
    ..Dental amalgam policies should consider Hg exposure in women before and during the child-bearing age and the possibility of subsequent fetal exposure and adverse outcomes...
  37. doi request reprint Thimerosal exposure and disturbance of emotions specific to childhood and adolescence: A case-control study in the Vaccine Safety Datalink (VSD) database
    David A Geier
    a The Institute of Chronic Illnesses, Inc, Silver Spring, MD, USA
    Brain Inj . 2017
    ..Thimerosal is an organic-mercury (Hg)-containing compound used in some vaccines...
  38. pmc Examining genotypic variation in autism spectrum disorder and its relationship to parental age and phenotype
    David A Geier
    Research Department, The Institute of Chronic Illnesses, Inc Research Department, CoMeD, Inc, Silver Spring, MD
    Appl Clin Genet 9:121-9. 2016
    ..Research suggests that parental age is a risk factor for an ASD diagnosis. This study examined genotypic variation in ASD and its relationship to parental age and phenotype...
  39. pmc Prospective, blinded exploratory evaluation of the PlayWisely program in children with autism spectrum disorder
    Janet K Kern
    Autism Treatment Center, Research Department, Dallas, Texas 75243, USA
    Yale J Biol Med 86:157-67. 2013
    ..Future studies are needed to see if this intervention can mitigate autism symptoms in very young children with ASD...
  40. ncbi request reprint A Two-Phase Case-Control Study of Autism Risk Among Children Born From the Late 1990s Through the Early 2000s in the United States
    David A Geier
    Department of Research, Institute of Chronic Illnesses, Inc, Silver Spring, MD, USA
    Med Sci Monit 22:5196-5202. 2016
    ..Vaccine programs have significantly reduced the morbidity and mortality associated with infectious disease, but Thimerosal should be removed from all vaccines...
  41. pmc Evidence of microglial activation in autism and its possible role in brain underconnectivity
    Juan I Rodriguez
    Stop Calling It Autism, Fort Worth, TX, USA
    Neuron Glia Biol 7:205-13. 2011
    ..Future studies that examine treatments that may reduce microglial activation and neuroinflammation, and ultimately help to mitigate symptoms in ASD, are warranted...
  42. pmc A prospective Cross-sectional Cohort Assessment of Health, Physical, and Behavioral Problems in Autism Spectrum Disorders
    David A Geier
    Institute of Chronic Illnesses, Inc, Silver Spring, MD, USA CoMeD, Inc, Silver Spring, MD, USA
    Maedica (Buchar) 7:193-200. 2012
    ..The present findings also suggest the ATEC provides an economical means for healthcare providers to identify health, physical, and behavioral problems in subjects diagnosed with an ASD...
  43. ncbi request reprint The pattern of sensory processing abnormalities in autism
    Janet K Kern
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9119, USA
    Autism 10:480-94. 2006
    ..These results suggest that sensory abnormalities in autism are global in nature (involving several modalities) but have the potential to improve with age...
  44. pmc Assessing physicians' use of treatment algorithms: Project IMPACTS study design and rationale
    Madhukar H Trivedi
    Department of Psychiatry, The University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9119, USA
    Contemp Clin Trials 28:192-212. 2007
    ..These new procedures and data points will also allow a more refined assessment of algorithm-driven treatment in the future...