Faith H A Osier

Summary

Affiliation: Kenya Medical Research Institute
Country: Kenya

Publications

  1. pmc What you see is not what you get: implications of the brevity of antibody responses to malaria antigens and transmission heterogeneity in longitudinal studies of malaria immunity
    Samson M Kinyanjui
    Kenyan Medical Research Institute KEMRI, Centre for Geographic Medicine Research Coast, PO Box 230, Kilifi 80108, Kenya
    Malar J 8:242. 2009
  2. pmc Allele-specific antibodies to Plasmodium falciparum merozoite surface protein-2 and protection against clinical malaria
    F H A Osier
    KEMRI Centre for Geographic Medicine Research, Coast, Kilifi, Kenya
    Parasite Immunol 32:193-201. 2010
  3. pmc Naturally acquired antibodies to polymorphic and conserved epitopes of Plasmodium falciparum merozoite surface protein 3
    F H A Osier
    London School of Hygiene and Tropical Medicine, Keppel Street, London, UK
    Parasite Immunol 29:387-94. 2007
  4. pmc Breadth and magnitude of antibody responses to multiple Plasmodium falciparum merozoite antigens are associated with protection from clinical malaria
    Faith H A Osier
    KEMRI Centre for Geographic Medicine Research, Coast, P O Box 230 80108, Kilifi, Kenya
    Infect Immun 76:2240-8. 2008
  5. pmc Allelic diversity and naturally acquired allele-specific antibody responses to Plasmodium falciparum apical membrane antigen 1 in Kenya
    Faith H A Osier
    KEMRI Centre for Geographic Medicine Research, Coast, Kilifi, Kenya
    Infect Immun 78:4625-33. 2010
  6. pmc A threshold concentration of anti-merozoite antibodies is required for protection from clinical episodes of malaria
    Linda M Murungi
    KEMRI Centre for Geographic Medicine Research, Coast, P O Box 230 80108, Kilifi, Kenya
    Vaccine 31:3936-42. 2013
  7. pmc Analysis of antibodies to newly described Plasmodium falciparum merozoite antigens supports MSPDBL2 as a predicted target of naturally acquired immunity
    Kevin K A Tetteh
    Department of Pathogen Molecular Biology, London School of Hygiene and Tropical Medicine, London, United Kingdom
    Infect Immun 81:3835-42. 2013
  8. pmc Cord blood IgG and the risk of severe Plasmodium falciparum malaria in the first year of life
    Linda M Murungi
    Kenya Medical Research Institute, Centre for Geographic Medicine Research, Coast, P O Box 230 80108, Kilifi, Kenya Electronic address
    Int J Parasitol . 2016
  9. pmc Targets and Mechanisms Associated with Protection from Severe Plasmodium falciparum Malaria in Kenyan Children
    Linda M Murungi
    KEMRI Wellcome Trust Research Programme, Centre for Geographical Medicine Research Coast, Kilifi, Kenya
    Infect Immun 84:950-63. 2016
  10. pmc Stable and unstable malaria hotspots in longitudinal cohort studies in Kenya
    Philip Bejon
    Kilifi KEMRI Wellcome Trust Collaborative Research Programme, Centre for Geographic Medicine Research Coast, Kilifi, Kenya
    PLoS Med 7:e1000304. 2010

Detail Information

Publications13

  1. pmc What you see is not what you get: implications of the brevity of antibody responses to malaria antigens and transmission heterogeneity in longitudinal studies of malaria immunity
    Samson M Kinyanjui
    Kenyan Medical Research Institute KEMRI, Centre for Geographic Medicine Research Coast, PO Box 230, Kilifi 80108, Kenya
    Malar J 8:242. 2009
    ..This approach has identified a number of important responses against malaria, but their protective efficacies vary considerably between studies...
  2. pmc Allele-specific antibodies to Plasmodium falciparum merozoite surface protein-2 and protection against clinical malaria
    F H A Osier
    KEMRI Centre for Geographic Medicine Research, Coast, Kilifi, Kenya
    Parasite Immunol 32:193-201. 2010
    ..Thus, even for this well-studied antigen, the importance of an allele-specific component of naturally acquired protective immunity to malaria remains to be confirmed...
  3. pmc Naturally acquired antibodies to polymorphic and conserved epitopes of Plasmodium falciparum merozoite surface protein 3
    F H A Osier
    London School of Hygiene and Tropical Medicine, Keppel Street, London, UK
    Parasite Immunol 29:387-94. 2007
    ..41 with 95% confidence interval 0.20-0.81, P = 0.011). The potential importance of allele-specific immunity to MSP3 should be considered in addition to immunity to conserved epitopes, in the development of an MSP3 malaria vaccine...
  4. pmc Breadth and magnitude of antibody responses to multiple Plasmodium falciparum merozoite antigens are associated with protection from clinical malaria
    Faith H A Osier
    KEMRI Centre for Geographic Medicine Research, Coast, P O Box 230 80108, Kilifi, Kenya
    Infect Immun 76:2240-8. 2008
    ....
  5. pmc Allelic diversity and naturally acquired allele-specific antibody responses to Plasmodium falciparum apical membrane antigen 1 in Kenya
    Faith H A Osier
    KEMRI Centre for Geographic Medicine Research, Coast, Kilifi, Kenya
    Infect Immun 78:4625-33. 2010
    ..Antibodies to both conserved and allele-specific epitopes in AMA1 may contribute to clinical protection...
  6. pmc A threshold concentration of anti-merozoite antibodies is required for protection from clinical episodes of malaria
    Linda M Murungi
    KEMRI Centre for Geographic Medicine Research, Coast, P O Box 230 80108, Kilifi, Kenya
    Vaccine 31:3936-42. 2013
    ..Our results have implications for the analysis and interpretation of similar data from immuno-epidemiological studies...
  7. pmc Analysis of antibodies to newly described Plasmodium falciparum merozoite antigens supports MSPDBL2 as a predicted target of naturally acquired immunity
    Kevin K A Tetteh
    Department of Pathogen Molecular Biology, London School of Hygiene and Tropical Medicine, London, United Kingdom
    Infect Immun 81:3835-42. 2013
    ..53, and 95% CI, 0.32 to 0.89), whereas the other antigens showed no protective associations after adjustment. These findings support the prediction that antibodies to the polymorphic region of MSPDBL2 contribute to protective immunity. ..
  8. pmc Cord blood IgG and the risk of severe Plasmodium falciparum malaria in the first year of life
    Linda M Murungi
    Kenya Medical Research Institute, Centre for Geographic Medicine Research, Coast, P O Box 230 80108, Kilifi, Kenya Electronic address
    Int J Parasitol . 2016
    ..74, P=0.007). Identification of the targets of antibodies mediating antibody-dependent respiratory burst activity could contribute to the development of malaria vaccines that protect against severe episodes of malaria in early infancy...
  9. pmc Targets and Mechanisms Associated with Protection from Severe Plasmodium falciparum Malaria in Kenyan Children
    Linda M Murungi
    KEMRI Wellcome Trust Research Programme, Centre for Geographical Medicine Research Coast, Kilifi, Kenya
    Infect Immun 84:950-63. 2016
    ..07). Our data provide epidemiological evidence that multiple antibody-dependent mechanisms contribute to protective immunity via distinct targets whose identification could accelerate the development of vaccines to protect against SM...
  10. pmc Stable and unstable malaria hotspots in longitudinal cohort studies in Kenya
    Philip Bejon
    Kilifi KEMRI Wellcome Trust Collaborative Research Programme, Centre for Geographic Medicine Research Coast, Kilifi, Kenya
    PLoS Med 7:e1000304. 2010
    ..This heterogeneity reduces the efficacy of control strategies, but also implies that focusing control strategies on "hotspots" of transmission could be highly effective...
  11. pmc Prognostic indicators of early and late death in children admitted to district hospital in Kenya: cohort study
    J A Berkley
    KEMRI Centre for Geographic Medicine Research Coast, PO Box 230, Kilifi, Kenya
    BMJ 326:361. 2003
    ..To identify clinical indicators of immediate, early, and late mortality in children at admission to a sub-Saharan district hospital and to develop prognostic scores...
  12. pmc Abnormal blood glucose concentrations on admission to a rural Kenyan district hospital: prevalence and outcome
    F H A Osier
    Kenya Medical Research Institute KEMRI, Centre for Geographic Medicine Research, Coast, Kilifi District Hospital, PO Box 230, Kilifi, Kenya
    Arch Dis Child 88:621-5. 2003
    ..To determine the prevalence, clinical characteristics, and outcome of hypoglycaemia on admission in children at a rural Kenyan district hospital...
  13. pmc Haemoglobin C and S role in acquired immunity against Plasmodium falciparum malaria
    Federica Verra
    Dipartimento di Scienze di Sanità Pubblica, Sezione di Parassitologia, University of Rome La Sapienza, Rome, Italy
    PLoS ONE 2:e978. 2007
    ..The enhanced immune reactivity in both HbC and HbS carriers supports the hypothesis that the protection against malaria of these adaptive genotypes might be at least partially mediated by acquired immunity against malaria...