Samuel Kariuki

Summary

Affiliation: Kenya Medical Research Institute
Country: Kenya

Publications

  1. ncbi request reprint Lack of clonal relationship between non-typhi Salmonella strain types from humans and those isolated from animals living in close contact
    Samuel Kariuki
    Centre for Microbiology Research, Kenya Medical Research Institute, P O Box 43640, Nairobi, Kenya
    FEMS Immunol Med Microbiol 33:165-71. 2002
  2. pmc Characterization of multidrug-resistant typhoid outbreaks in Kenya
    Samuel Kariuki
    Centre for Microbiology Research, Kenya Medical Research Institute, Nairobi, Kenya
    J Clin Microbiol 42:1477-82. 2004
  3. pmc Genomic and phenotypic variation in epidemic-spanning Salmonella enterica serovar Enteritidis isolates
    Laura Betancor
    Departamento de Desarrollo Biotecnológico, Instituto de Higiene, Universidad de la Republica, Montevideo, Uruguay
    BMC Microbiol 9:237. 2009
  4. pmc Molecular characterisation of Vibrio cholerae O1 strains carrying an SXT/R391-like element from cholera outbreaks in Kenya: 1994-2007
    John N Kiiru
    Centre for Microbiology Research, Kenya Medical Research Institute, PO Box 43640, Nairobi, Kenya
    BMC Microbiol 9:275. 2009
  5. ncbi request reprint Typhoid fever in sub-Saharan Africa: challenges of diagnosis and management of infections
    Samuel Kariuki
    Centre for Microbiology Research, Kenya Medical Research Institute, Nairobi, Kenya
    J Infect Dev Ctries 2:443-7. 2008
  6. ncbi request reprint Escherichia coli from community-acquired urinary tract infections resistant to fluoroquinolones and extended-spectrum beta-lactams
    Samuel Kariuki
    Centre for Microbiology Research, Kenya Medical Research Institute, Nairobi, Kenya
    J Infect Dev Ctries 1:257-62. 2007
  7. pmc Typhoid in Kenya is associated with a dominant multidrug-resistant Salmonella enterica serovar Typhi haplotype that is also widespread in Southeast Asia
    Samuel Kariuki
    Centre for Microbiology Research, Kenya Medical Research Institute, P O Box 43640 00100, Nairobi, Kenya
    J Clin Microbiol 48:2171-6. 2010
  8. pmc Characterisation of community acquired non-typhoidal Salmonella from bacteraemia and diarrhoeal infections in children admitted to hospital in Nairobi, Kenya
    Samuel Kariuki
    Centre for Microbiology Research, Kenya Medical Research Institute, Nairobi, Kenya
    BMC Microbiol 6:101. 2006
  9. ncbi request reprint Decreasing prevalence of antimicrobial resistance in non-typhoidal Salmonella isolated from children with bacteraemia in a rural district hospital, Kenya
    Samuel Kariuki
    Centre for Microbiology Research, Kenyatta National Hospital, P O Box 20723, Nairobi, Kenya
    Int J Antimicrob Agents 28:166-71. 2006
  10. ncbi request reprint Invasive multidrug-resistant non-typhoidal Salmonella infections in Africa: zoonotic or anthroponotic transmission?
    Samuel Kariuki
    Centre for Microbiology Research, Kenya Medical Research Institute, PO Box 43640, Nairobi, Kenya
    J Med Microbiol 55:585-91. 2006

Collaborators

Detail Information

Publications26

  1. ncbi request reprint Lack of clonal relationship between non-typhi Salmonella strain types from humans and those isolated from animals living in close contact
    Samuel Kariuki
    Centre for Microbiology Research, Kenya Medical Research Institute, P O Box 43640, Nairobi, Kenya
    FEMS Immunol Med Microbiol 33:165-71. 2002
    ..Braenderup and S. Agona from cows and pigs were clustered together in one group. There was no significant relatedness between NTS isolates from humans and those from animals, food or the environment in close contact to humans...
  2. pmc Characterization of multidrug-resistant typhoid outbreaks in Kenya
    Samuel Kariuki
    Centre for Microbiology Research, Kenya Medical Research Institute, Nairobi, Kenya
    J Clin Microbiol 42:1477-82. 2004
    ..As the prevalence of multidrug-resistant serovar Typhi increases, newer, more expensive, and less readily available antimicrobial agents will be required for the treatment of typhoid in Kenya...
  3. pmc Genomic and phenotypic variation in epidemic-spanning Salmonella enterica serovar Enteritidis isolates
    Laura Betancor
    Departamento de Desarrollo Biotecnológico, Instituto de Higiene, Universidad de la Republica, Montevideo, Uruguay
    BMC Microbiol 9:237. 2009
    ..In this study we investigate genome divergence and pathogenic potential in S. Enteritidis isolated before, during and after an epidemic in Uruguay...
  4. pmc Molecular characterisation of Vibrio cholerae O1 strains carrying an SXT/R391-like element from cholera outbreaks in Kenya: 1994-2007
    John N Kiiru
    Centre for Microbiology Research, Kenya Medical Research Institute, PO Box 43640, Nairobi, Kenya
    BMC Microbiol 9:275. 2009
    ....
  5. ncbi request reprint Typhoid fever in sub-Saharan Africa: challenges of diagnosis and management of infections
    Samuel Kariuki
    Centre for Microbiology Research, Kenya Medical Research Institute, Nairobi, Kenya
    J Infect Dev Ctries 2:443-7. 2008
    ....
  6. ncbi request reprint Escherichia coli from community-acquired urinary tract infections resistant to fluoroquinolones and extended-spectrum beta-lactams
    Samuel Kariuki
    Centre for Microbiology Research, Kenya Medical Research Institute, Nairobi, Kenya
    J Infect Dev Ctries 1:257-62. 2007
    ..coli isolated from patients with urinary tract infections (UTIs)...
  7. pmc Typhoid in Kenya is associated with a dominant multidrug-resistant Salmonella enterica serovar Typhi haplotype that is also widespread in Southeast Asia
    Samuel Kariuki
    Centre for Microbiology Research, Kenya Medical Research Institute, P O Box 43640 00100, Nairobi, Kenya
    J Clin Microbiol 48:2171-6. 2010
    ..Given the emergence of this aggressive MDR haplotype, careful selection and monitoring of antibiotic usage will be required in Kenya, and potentially other regions of sub-Saharan Africa...
  8. pmc Characterisation of community acquired non-typhoidal Salmonella from bacteraemia and diarrhoeal infections in children admitted to hospital in Nairobi, Kenya
    Samuel Kariuki
    Centre for Microbiology Research, Kenya Medical Research Institute, Nairobi, Kenya
    BMC Microbiol 6:101. 2006
    ..The emergence of multidrug resistance is a major challenge in treatment of life threatening invasive NTS infections in these settings...
  9. ncbi request reprint Decreasing prevalence of antimicrobial resistance in non-typhoidal Salmonella isolated from children with bacteraemia in a rural district hospital, Kenya
    Samuel Kariuki
    Centre for Microbiology Research, Kenyatta National Hospital, P O Box 20723, Nairobi, Kenya
    Int J Antimicrob Agents 28:166-71. 2006
    ..01). All NTS remained fully susceptible to cefotaxime and ciprofloxacin. Our findings show that commonly available drugs may still be useful for treatment of invasive NTS infections in this rural population...
  10. ncbi request reprint Invasive multidrug-resistant non-typhoidal Salmonella infections in Africa: zoonotic or anthroponotic transmission?
    Samuel Kariuki
    Centre for Microbiology Research, Kenya Medical Research Institute, PO Box 43640, Nairobi, Kenya
    J Med Microbiol 55:585-91. 2006
    ..9% of human contacts from 27 out of 127 homes sampled. This population of carriers may represent an important reservoir of NTS that would play a significant role in the epidemiology of community-acquired NTS bacteraemia in children...
  11. ncbi request reprint Increasing prevalence of multidrug-resistant non-typhoidal salmonellae, Kenya, 1994-2003
    Samuel Kariuki
    Centre for Microbiology Research, Kenya Medical Research Institute, PO Box 43640, Nairobi, Kenya
    Int J Antimicrob Agents 25:38-43. 2005
    ..Although the genotypes of NTS remained fairly stable over the last decade, the large increase in MICs of all commonly used drugs and increased MICs of ciprofloxacin, poses a major challenge for treatment of invasive NTS infection...
  12. pmc Analysis for prevalence and physical linkages amongst integrons, ISEcp1, ISCR1, Tn21 and Tn7 encountered in Escherichia coli strains from hospitalized and non-hospitalized patients in Kenya during a 19-year period (1992-2011)
    John Kiiru
    Centre for Microbiology Research, Kenya Medical Research Institute, PO Box 19464 00202, Nairobi, Kenya
    BMC Microbiol 13:109. 2013
    ..We determined the prevalence and evidence for physical linkage amongst integrons, insertion sequences, Tn21 and Tn7 transposons in a collection of 1327 E. coli obtained over a 19-year period from patients in Kenya...
  13. ncbi request reprint Typhoid is over-reported in Embu and Nairobi, Kenya
    Samuel Kariuki
    Kenya Medical Research Institute, Centre for Microbiology Research P O Box 43640, Nairobi
    Afr J Health Sci 11:103-10. 2004
    ..Newer improved methods that are more specific and sensitive than the Widal test need to be evaluated in improving laboratory diagnosis of typhoid...
  14. pmc Analysis of β-lactamase phenotypes and carriage of selected β-lactamase genes among Escherichia coli strains obtained from Kenyan patients during an 18-year period
    John Kiiru
    Centre for Microbiology Research, Kenya Medical Research Institute, Nairobi, Kenya
    BMC Microbiol 12:155. 2012
    ..We screened for major β-lactamase phenotypes and diversity of bla genes among 912 E. coli strains isolated from clinical samples obtained between 1992 and 2010 from hospitalized and non-hospitalized patients...
  15. ncbi request reprint Genotypes and cephalosporin susceptibility in extended-spectrum beta-lactamase producing enterobacteriaceae in the community
    Daniel Maina
    Department of Pathology, Aga Khan University Hospital, Nairobi, Kenya
    J Infect Dev Ctries 6:470-7. 2012
    ..In the present study ESBLs genotypes were correlated with susceptibility to cephalosporins among ESBL-producing Escherichia coli and Klebsiella pneumoniae isolates acquired in the community...
  16. ncbi request reprint Helicobacter pylori: prevalence and antibiotic susceptibility among Kenyans
    Andrew Nyerere Kimang'a
    Medical Microbiology Subdepartment, Jomo Kenyatta University of Agriculture and Technology, Nairobi, Kenya
    S Afr Med J 100:53-7. 2010
    ..Helicobacter pylori infection in Kenya is staggeringly high. Evidence links infection of the gastric mucosa by H. pylori with subsequent development of gastric pathologies...
  17. pmc A study on the geophylogeny of clinical and environmental Vibrio cholerae in Kenya
    John Kiiru
    Centre for Microbiology Research, Kenya Medical Research Institute, Nairobi, Kenya
    PLoS ONE 8:e74829. 2013
    ..cholerae isolated elsewhere in the world and similarly harbour antibiotic resistance-associated STX elements. Further, the Kenyan O1 El Tor isolates fall into two distinct clades that may have entered Kenya independently. ..
  18. doi request reprint Molecular characterization of virulence factors in diarrhoeagenic Escherichia coli isolates from children in Nairobi, Kenya
    Celestine Khalechi Makobe
    Jomo Kenyatta University of Agriculture and Technology, Nairobi, Kenya
    J Infect Dev Ctries 6:598-604. 2012
    ..New evidence suggests that major differences in virulence among groups of DEC pathotypes may be related to the presence of specific pathogenicity islands (PAIs)...
  19. pmc Ceftriaxone-resistant Salmonella enterica serotype typhimurium sequence type 313 from Kenyan patients is associated with the blaCTX-M-15 gene on a novel IncHI2 plasmid
    Samuel Kariuki
    Centre for Microbiology Research, Kenya Medical Research Institute, Nairobi, Kenya The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, United Kingdom
    Antimicrob Agents Chemother 59:3133-9. 2015
    ..Typhimurium ST313, the major clone of an ongoing invasive NTS epidemic in the region. This emerging ceftriaxone-resistant clone may pose a major challenge in the management of invasive NTS in sub-Saharan Africa...
  20. ncbi request reprint Rapid spread of Vibrio cholerae O1 throughout Kenya, 2005
    Isaac Mugoya
    Field Epidemiology and Laboratory Training Program Kenya, CDC, Nairobi, Kenya
    Am J Trop Med Hyg 78:527-33. 2008
    ..Prevention measures remain implementation of point-of-use safe water systems and case finding and referral...
  21. pmc Molecular characterization of Staphylococcus aureus isolates from various healthcare institutions in Nairobi, Kenya: a cross sectional study
    Geoffrey Omuse
    Department of Pathology, Aga Khan University Hospital Nairobi, P O Box 30270 00100, Nairobi, Kenya
    Ann Clin Microbiol Antimicrob 15:51. 2016
    ..In order to better understand the epidemiology of MRSA in a setting, it is important to define its population structure using molecular tools as different clones have been found to predominate in certain geographical locations...
  22. ncbi request reprint Resistance patterns of Mycobacterium tuberculosis isolates from pulmonary tuberculosis patients in Nairobi
    Perpetual Wangui Ndung'u
    Institute of Tropical Medicine and Infectious Diseases ITROMID, Jomo Kenyatta University of Agriculture and Technology JKUAT, Nairobi, Kenya
    J Infect Dev Ctries 6:33-9. 2012
    ..This study aimed to determine resistance patterns of Mycobacterium tuberculosis isolated from pulmonary samples...
  23. pmc Enteric pathogens and factors associated with acute bloody diarrhoea, Kenya
    Charles Njuguna
    Jomo Kenyatta University of Agriculture and Technology, Nairobi, Kenya
    BMC Infect Dis 16:477. 2016
    ..In Kenya, bloody diarrhoea is reported weekly as part of priority diseases under Integrated Disease Surveillance and Response System (IDSR) in the Ministry of Health...
  24. pmc Epidemiology and Genomics of Invasive Nontyphoidal Salmonella Infections in Kenya
    Samuel Kariuki
    Centre for Microbiology Research, Kenya Medical Research Institute, Nairobi
    Clin Infect Dis 61:S317-24. 2015
    ..The incidence of iNTS disease in children ranges from 166 to 568 cases per 100,000 persons per year...
  25. pmc Relationship between antibody susceptibility and lipopolysaccharide O-antigen characteristics of invasive and gastrointestinal nontyphoidal Salmonellae isolates from Kenya
    Robert S Onsare
    Centre for Microbiology Research CMR, Kenya Medical Research Institute KEMRI, Nairobi, Kenya Jomo Kenyatta University of Agriculture and Technology JKUAT, Nairobi, Kenya
    PLoS Negl Trop Dis 9:e0003573. 2015
    ..We hypothesised that isolates with more O-antigen have increased resistance to antibody-mediated killing and are more likely to be invasive than gastrointestinal...
  26. pmc A cross-sectional study on the microbiological quality and safety of raw chicken meats sold in Nairobi, Kenya
    Joyce Arua Odwar
    Centre for Microbiology Research, Kenya Medical Research Institute, P, O Box 43640 00100, Nairobi, Kenya
    BMC Res Notes 7:627. 2014
    ..coli/coliform contamination levels as well as the antimicrobial resistance patterns and pathogenicity of E. coli isolated...