- Primary support cultures of hippocampal and substantia nigra neurons
Oncology Research Unit, The Children s Hospital at Westmead, Sydney, Westmead, New South Wales 2145, Australia
Nat Protoc 4:78-85. 2009
..This method has been adopted for neurons from the substantia nigra (E16.5), with support from a ring of striatal neurons...
- Cytoplasmic accumulation and aggregation of TDP-43 upon proteasome inhibition in cultured neurons
Janet van Eersel
Laboratory for Translational Neurodegeneration, Brain and Mind Research Institute, University of Sydney, Sydney, Australia
PLoS ONE 6:e22850. 2011
..Taken together, our data suggests a role for the proteasome in subcellular localization of TDP-43, and possibly in disease...
- Phosphorylation of soluble tau differs in Pick's disease and Alzheimer's disease brains
Janet van Eersel
Discipline of Pathology, The University of Sydney, Sydney, NSW, 2006, Australia
J Neural Transm (Vienna) 116:1243-51. 2009
..Such differences in solubility and phosphorylation may contribute, at least in part, to the formation of distinct tau deposits, but may also have implications for the clinical differences between AD and PiD...
- Experimental diabetes mellitus exacerbates tau pathology in a transgenic mouse model of Alzheimer's disease
Yazi D Ke
Alzheimer s and Parkinson s Disease Laboratory, Brain and Mind Research Institute, University of Sydney, Sydney, Australia
PLoS ONE 4:e7917. 2009
..Hence, DM can accelerate onset and increase severity of disease in individuals with a predisposition to developing tau pathology...
- ERK inhibition with PD184161 mitigates brain damage in a mouse model of stroke
Dementia Research Unit DRU, School of Medical Sciences, The University of New South Wales, Sydney, NSW, 2052, Australia
J Neural Transm (Vienna) 121:543-7. 2014
..This further supports ERK inhibition as a potential treatment for stroke. ..
- Neuronal microRNA deregulation in response to Alzheimer's disease amyloid-beta
Alzheimer s and Parkinson s Disease Laboratory, Brain and Mind Research Institute, University of Sydney, Sydney, New South Wales, Australia
PLoS ONE 5:e11070. 2010
..Taken together, our findings suggest that neuronal miRNA deregulation in response to an insult by Abeta may be an important factor contributing to the cascade of events leading to AD...
- Aβ-dependent reduction of NCAM2-mediated synaptic adhesion contributes to synapse loss in Alzheimer's disease
School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, New South Wales 2052, Australia
Nat Commun 6:8836. 2015
..Our data indicate that Aβ-dependent disruption of NCAM2 functions in AD hippocampus contributes to synapse loss. ..
- Short-term suppression of A315T mutant human TDP-43 expression improves functional deficits in a novel inducible transgenic mouse model of FTLD-TDP and ALS
Yazi D Ke
Dementia Research Unit, Department of Anatomy, Faculty of Medicine, School of Medical Sciences, UNSW Australia, Sydney, NSW, 2052, Australia
Acta Neuropathol 130:661-78. 2015
..Furthermore, it illustrates the compensatory capacity of compromised neurons once transgenic TDP-43 is removed, with implications for future treatments...
- Phosphorylated Tau interacts with c-Jun N-terminal kinase-interacting protein 1 (JIP1) in Alzheimer disease
Lars M Ittner
Alzheimer s and Parkinson s Disease Laboratory, Brain and Mind Research Institute, University of Sydney, Sydney, Camperdown, New South Wales 2050, Australia
J Biol Chem 284:20909-16. 2009
..Because JIP1 is involved in regulating cargo binding to kinesin motors, our findings may, at least in part, explain how hyperphosphorylated Tau mediates impaired axonal transport in AD and frontotemporal dementia...