Nasiara Karim

Summary

Publications

  1. doi 3-Hydroxy-2'-methoxy-6-methylflavone: a potent anxiolytic with a unique selectivity profile at GABA(A) receptor subtypes
    Nasiara Karim
    University of Sydney, Sydney NSW, 2006, Australia
    Biochem Pharmacol 82:1971-83. 2011
  2. doi Low nanomolar GABA effects at extrasynaptic α4β1/β3δ GABA(A) receptor subtypes indicate a different binding mode for GABA at these receptors
    Nasiara Karim
    Faculty of Pharmacy, Department of Pharmacology, University of Sydney, Sydney, NSW 2006, Australia
    Biochem Pharmacol 84:549-57. 2012
  3. doi Potency of GABA at human recombinant GABA(A) receptors expressed in Xenopus oocytes: a mini review
    Nasiara Karim
    Faculty of Pharmacy A15, University of Sydney, Sydney, NSW, 2006, Australia
    Amino Acids 44:1139-49. 2013
  4. pmc Covalent trapping of methyllycaconitine at the α4-α4 interface of the α4β2 nicotinic acetylcholine receptor: antagonist binding site and mode of receptor inhibition revealed
    Nathan L Absalom
    From the Faculty of Pharmacy, University of Sydney, Sydney, NSW 2006, Australia
    J Biol Chem 288:26521-32. 2013
  5. pmc 2'-Methoxy-6-methylflavone: a novel anxiolytic and sedative with subtype selective activating and modulating actions at GABA(A) receptors
    Nasiara Karim
    Faculty of Pharmacy A15, University of Sydney, Sydney, NSW, Australia
    Br J Pharmacol 165:880-96. 2012
  6. pmc α4βδ GABA(A) receptors are high-affinity targets for γ-hydroxybutyric acid (GHB)
    Nathan Absalom
    Faculty of Pharmacy A15, University of Sydney, Sydney, New South Wales 2006, Australia
    Proc Natl Acad Sci U S A 109:13404-9. 2012
  7. pmc Flavan-3-ol esters: new agents for exploring modulatory sites on GABA(A) receptors
    Sebastian P Fernandez
    Department of Pharmacology Faculty of Pharmacy, The University of Sydney, Sydney, New South Wales, Australia
    Br J Pharmacol 165:965-77. 2012
  8. doi Modulation of ionotropic GABA receptors by 6-methoxyflavanone and 6-methoxyflavone
    Belinda J Hall
    Department of Pharmacology, The University of Sydney, Sydney, NSW, 2006, Australia
    Neurochem Res 39:1068-78. 2014
  9. ncbi Antidepressant, Anxiolytic and Antinociceptive Activities of Constituents from Rosmarinus Officinalis
    Abeer Abdelhalim
    Faculty of Pharmacy, University of Sydney, Sydney, Australia Faculty of Science, Taibah University, Almadina Almonawara, Saudi Arabia
    J Pharm Pharm Sci 18:448-59. 2015

Collaborators

Detail Information

Publications9

  1. doi 3-Hydroxy-2'-methoxy-6-methylflavone: a potent anxiolytic with a unique selectivity profile at GABA(A) receptor subtypes
    Nasiara Karim
    University of Sydney, Sydney NSW, 2006, Australia
    Biochem Pharmacol 82:1971-83. 2011
    ....
  2. doi Low nanomolar GABA effects at extrasynaptic α4β1/β3δ GABA(A) receptor subtypes indicate a different binding mode for GABA at these receptors
    Nasiara Karim
    Faculty of Pharmacy, Department of Pharmacology, University of Sydney, Sydney, NSW 2006, Australia
    Biochem Pharmacol 84:549-57. 2012
    ..Taken together, GABA may have different binding modes for extrasynaptic δ-containing GABA(A) receptors compared to their synaptic counterparts...
  3. doi Potency of GABA at human recombinant GABA(A) receptors expressed in Xenopus oocytes: a mini review
    Nasiara Karim
    Faculty of Pharmacy A15, University of Sydney, Sydney, NSW, 2006, Australia
    Amino Acids 44:1139-49. 2013
    ..At α4β2δ, GABA had low micromolar activity...
  4. pmc Covalent trapping of methyllycaconitine at the α4-α4 interface of the α4β2 nicotinic acetylcholine receptor: antagonist binding site and mode of receptor inhibition revealed
    Nathan L Absalom
    From the Faculty of Pharmacy, University of Sydney, Sydney, NSW 2006, Australia
    J Biol Chem 288:26521-32. 2013
    ..Consistent with other studies, we propose that the α4-α4 interface is a structural target for potential therapeutics that modulate (α4)3(β2)2 nAChRs. ..
  5. pmc 2'-Methoxy-6-methylflavone: a novel anxiolytic and sedative with subtype selective activating and modulating actions at GABA(A) receptors
    Nasiara Karim
    Faculty of Pharmacy A15, University of Sydney, Sydney, NSW, Australia
    Br J Pharmacol 165:880-96. 2012
    ..Flavonoids are known to have anxiolytic and sedative effects mediated via actions on ionotropic GABA receptors. We sought to investigate this further...
  6. pmc α4βδ GABA(A) receptors are high-affinity targets for γ-hydroxybutyric acid (GHB)
    Nathan Absalom
    Faculty of Pharmacy A15, University of Sydney, Sydney, New South Wales 2006, Australia
    Proc Natl Acad Sci U S A 109:13404-9. 2012
    ..This finding will aid in elucidating the molecular mechanisms behind the proposed function of GHB as a neurotransmitter and its unique therapeutic effects in narcolepsy and alcoholism...
  7. pmc Flavan-3-ol esters: new agents for exploring modulatory sites on GABA(A) receptors
    Sebastian P Fernandez
    Department of Pharmacology Faculty of Pharmacy, The University of Sydney, Sydney, New South Wales, Australia
    Br J Pharmacol 165:965-77. 2012
    ..In this study we further investigated the interactions between these agents...
  8. doi Modulation of ionotropic GABA receptors by 6-methoxyflavanone and 6-methoxyflavone
    Belinda J Hall
    Department of Pharmacology, The University of Sydney, Sydney, NSW, 2006, Australia
    Neurochem Res 39:1068-78. 2014
    ..The relative inactivity of 6-methoxyflavanone at α1β2 GABAA receptors and it's partial agonist action at ρ1W328 M GABA receptors suggest that it exhibits a unique profile not matched by other flavonoids. ..
  9. ncbi Antidepressant, Anxiolytic and Antinociceptive Activities of Constituents from Rosmarinus Officinalis
    Abeer Abdelhalim
    Faculty of Pharmacy, University of Sydney, Sydney, Australia Faculty of Science, Taibah University, Almadina Almonawara, Saudi Arabia
    J Pharm Pharm Sci 18:448-59. 2015
    ..However, few studies have investigated the effects of non-volatile components of rosemary on central nervous system function...