Matt Kaeberlein

Summary

Publications

  1. pmc Increased life span due to calorie restriction in respiratory-deficient yeast
    Matt Kaeberlein
    Department of Genome Sciences, University of Washington, Seattle, Washington, United States of America
    PLoS Genet 1:e69. 2005
  2. pmc Yeast life span extension by depletion of 60s ribosomal subunits is mediated by Gcn4
    Kristan K Steffen
    Department of Biochemistry, University of Washington, Seattle, WA 98195, USA
    Cell 133:292-302. 2008
  3. ncbi request reprint AGEID: a database of aging genes and interventions
    Matt Kaeberlein
    Longenity Inc, Medford, MA 02153, USA
    Mech Ageing Dev 123:1115-9. 2002
  4. pmc High osmolarity extends life span in Saccharomyces cerevisiae by a mechanism related to calorie restriction
    Matt Kaeberlein
    Longenity, Inc, Waltham, Massachusetts 02451, USA
    Mol Cell Biol 22:8056-66. 2002
  5. ncbi request reprint Lifespan extension in Caenorhabditis elegans by complete removal of food
    Tammi L Kaeberlein
    Department of Microbiology, University of Washington, Seattle, WA, USA
    Aging Cell 5:487-94. 2006
  6. ncbi request reprint Comment on "HST2 mediates SIR2-independent life-span extension by calorie restriction"
    Matt Kaeberlein
    Department of Pathology, University of Washington, Seattle, WA 98195, USA
    Science 312:1312; author reply 1312. 2006
  7. ncbi request reprint Sirtuin-independent effects of nicotinamide on lifespan extension from calorie restriction in yeast
    Mitsuhiro Tsuchiya
    Department of Biochemistry, University of Washington, Seattle, WA 98195, USA
    Aging Cell 5:505-14. 2006
  8. ncbi request reprint The enigmatic role of Sir2 in aging
    Brian K Kennedy
    Department of Biochemistry, University of Washington, Seattle, Washington 98195, USA
    Cell 123:548-50. 2005
  9. ncbi request reprint Sir2 and calorie restriction in yeast: a skeptical perspective
    Matt Kaeberlein
    Department of Pathology, University of Washington, Seattle, WA 98195, USA
    Ageing Res Rev 6:128-40. 2007
  10. ncbi request reprint Substrate-specific activation of sirtuins by resveratrol
    Matt Kaeberlein
    Department of Genome Sciences, University of Washington, Seattle, Washington 98195, USA
    J Biol Chem 280:17038-45. 2005

Collaborators

  • Leonard P Guarente
  • Brian Kennedy
  • R Wilson Powers
  • STANLEY H FIELDS
  • Thomas E Johnson
  • Su Ju Lin
  • Antonio Bedalov
  • RITA BRICKMAN EFFROS
  • Erica D Smith
  • Mitsuhiro Tsuchiya
  • Emily O Kerr
  • George L Sutphin
  • Daniel Lockshon
  • Kristan K Steffen
  • Di Hu
  • K Linnea Welton
  • Nick Dang
  • Tammi L Kaeberlein
  • Lindsay A Fox
  • Elijah D Johnston
  • Tom Schmidlin
  • Diana N Pak
  • Christopher J Murakami
  • Bie N Tchao
  • Katherine A Steinkraus
  • Jonathan A Oakes
  • James H Thomas
  • Christopher M Armstrong
  • Christina Davis
  • William R Pendergrass
  • Brian A Kudlow
  • Jennifer Sager
  • Daniel Carr
  • Daniel E L Promislow
  • Vivian L MacKay
  • Vivian MacKay
  • Brynn T Lydum
  • Christopher R Burtner
  • Lauren E Surface
  • Shin Ichiro Imai

Detail Information

Publications37

  1. pmc Increased life span due to calorie restriction in respiratory-deficient yeast
    Matt Kaeberlein
    Department of Genome Sciences, University of Washington, Seattle, Washington, United States of America
    PLoS Genet 1:e69. 2005
    ....
  2. pmc Yeast life span extension by depletion of 60s ribosomal subunits is mediated by Gcn4
    Kristan K Steffen
    Department of Biochemistry, University of Washington, Seattle, WA 98195, USA
    Cell 133:292-302. 2008
    ..Genetic epistasis analyses suggest that dietary restriction, reduced 60S subunit abundance, and Gcn4 activation extend yeast life span by similar mechanisms...
  3. ncbi request reprint AGEID: a database of aging genes and interventions
    Matt Kaeberlein
    Longenity Inc, Medford, MA 02153, USA
    Mech Ageing Dev 123:1115-9. 2002
    ..The use of this database by researchers who study aging should facilitate easy comparison of the genes and interventions that affect life span in different organisms...
  4. pmc High osmolarity extends life span in Saccharomyces cerevisiae by a mechanism related to calorie restriction
    Matt Kaeberlein
    Longenity, Inc, Waltham, Massachusetts 02451, USA
    Mol Cell Biol 22:8056-66. 2002
    ..This metabolic shift likely increases NAD levels, thereby activating Sir2p and promoting longevity...
  5. ncbi request reprint Lifespan extension in Caenorhabditis elegans by complete removal of food
    Tammi L Kaeberlein
    Department of Microbiology, University of Washington, Seattle, WA, USA
    Aging Cell 5:487-94. 2006
    ..Removal of bacterial food also increases lifespan when initiated in postreproductive adults, suggesting that dietary restriction started during middle age can result in a substantial longevity benefit that is independent of reproduction...
  6. ncbi request reprint Comment on "HST2 mediates SIR2-independent life-span extension by calorie restriction"
    Matt Kaeberlein
    Department of Pathology, University of Washington, Seattle, WA 98195, USA
    Science 312:1312; author reply 1312. 2006
    ..Contradictory to this, we find that CR greatly increases life span in cells lacking Sir2, Hst1, and Hst2, which suggests that CR is not mediated by Sir2, Hst2, or Hst1...
  7. ncbi request reprint Sirtuin-independent effects of nicotinamide on lifespan extension from calorie restriction in yeast
    Mitsuhiro Tsuchiya
    Department of Biochemistry, University of Washington, Seattle, WA 98195, USA
    Aging Cell 5:505-14. 2006
    ..Thus, we propose that lifespan extension by CR is independent of sirtuins and that nicotinamide has sirtuin-independent effects on lifespan extension by CR...
  8. ncbi request reprint The enigmatic role of Sir2 in aging
    Brian K Kennedy
    Department of Biochemistry, University of Washington, Seattle, Washington 98195, USA
    Cell 123:548-50. 2005
    ..In contrast to measurements of aging for mitotic cells, cell survival in the nonmitotic state is decreased by Sir2 activity under conditions that mimic calorie restriction...
  9. ncbi request reprint Sir2 and calorie restriction in yeast: a skeptical perspective
    Matt Kaeberlein
    Department of Pathology, University of Washington, Seattle, WA 98195, USA
    Ageing Res Rev 6:128-40. 2007
    ..These shortcomings must be considered along with evidence supporting a role for Sir2 in CR in order to fully evaluate the validity of this model...
  10. ncbi request reprint Substrate-specific activation of sirtuins by resveratrol
    Matt Kaeberlein
    Department of Genome Sciences, University of Washington, Seattle, Washington 98195, USA
    J Biol Chem 280:17038-45. 2005
    ..In light of these findings, the mechanism accounting for putative longevity effects of resveratrol should be reexamined...
  11. pmc Recent developments in yeast aging
    Matt Kaeberlein
    Department of Pathology, University of Washington, Seattle, Washington, United States of America
    PLoS Genet 3:e84. 2007
    ..Here we briefly outline aging in yeast and describe recent findings that continue to keep this "simple" eukaryote at the forefront of aging research...
  12. ncbi request reprint Does resveratrol activate yeast Sir2 in vivo?
    Matt Kaeberlein
    Aging Cell 6:415-6. 2007
  13. pmc Sir2-independent life span extension by calorie restriction in yeast
    Matt Kaeberlein
    Department of Genome Sciences, University of Washington, Seattle, Washington, USA
    PLoS Biol 2:E296. 2004
    ..These findings indicate that Sir2 and calorie restriction act in parallel pathways to promote longevity in yeast and, perhaps, higher eukaryotes...
  14. pmc Saccharomyces cerevisiae SSD1-V confers longevity by a Sir2p-independent mechanism
    Matt Kaeberlein
    Department of Genome Sciences, University of Washington, Seattle, Washington 98195, USA
    Genetics 166:1661-72. 2004
    ..We propose that SSD1-V defines a previously undescribed pathway affecting cellular longevity and suggest that future studies on longevity-promoting genes should be carried out in long-lived SSD1-V strains...
  15. ncbi request reprint Calorie restriction extends Saccharomyces cerevisiae lifespan by increasing respiration
    Su Ju Lin
    Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Nature 418:344-8. 2002
    ..We discuss how this metabolic strategy may apply to CR in animals...
  16. pmc Mutations in Saccharomyces cerevisiae gene SIR2 can have differential effects on in vivo silencing phenotypes and in vitro histone deacetylation activity
    Christopher M Armstrong
    Department of Biology, Massachussetts Institute of Technology, Cambridge, MA 02139, USA
    Mol Biol Cell 13:1427-38. 2002
    ..We also show that the histone deacetylase activity of Sir2p is necessary for the proper localiztion of the SIR complex to the telomeres...
  17. ncbi request reprint A method for high-throughput quantitative analysis of yeast chronological life span
    Christopher J Murakami
    Department of Pathology, University of Washington, Box 357470, Seattle, WA 98195 7470, USA
    J Gerontol A Biol Sci Med Sci 63:113-21. 2008
    ..We also report that life-span extension from dietary restriction does not require any of the five yeast sirtuins (Sir2, Hst1, Hst2, Hst3, or Hst4) either alone or in combination...
  18. ncbi request reprint Single-gene deletions that restore mating competence to diploid yeast
    Tom Schmidlin
    Department of Biochemistry, University of Washington, Seattle, WA 98195, USA
    FEMS Yeast Res 8:276-86. 2008
    ..In summary, this study underscores and elaborates upon predicted pathways by which mutations restore mating function to yeast diploids and identifies new mutants warranting further study...
  19. ncbi request reprint Dietary restriction by bacterial deprivation increases life span in wild-derived nematodes
    George L Sutphin
    Department of Pathology, University of Washington, Seattle, WA 98195 7470, USA
    Exp Gerontol 43:130-5. 2008
    ..remanei strains. Thus, we find no evidence that adaptation to laboratory conditions has significantly altered the aging process in C. elegans under either standard or food-restricted conditions...
  20. pmc Dietary restriction suppresses proteotoxicity and enhances longevity by an hsf-1-dependent mechanism in Caenorhabditis elegans
    Katherine A Steinkraus
    Department of Pathology, University of Washington, Seattle, WA 98195, USA
    Aging Cell 7:394-404. 2008
    ..These findings demonstrate that dietary restriction confers a general protective effect against proteotoxicity and promotes longevity by a mechanism involving hsf-1...
  21. pmc Quantitative evidence for conserved longevity pathways between divergent eukaryotic species
    Erica D Smith
    Department of Biochemistry, University of Washington, Seattle, Washington 98195, USA
    Genome Res 18:564-70. 2008
    ..Together, these findings indicate that the genetic component of life span determination is significantly conserved between divergent eukaryotic species, and suggest pathways that are likely to play a similar role in mammalian aging...
  22. pmc Saccharomyces cerevisiae MPT5 and SSD1 function in parallel pathways to promote cell wall integrity
    Matt Kaeberlein
    Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Genetics 160:83-95. 2002
    ..This work also provides evidence that post-transcriptional regulation is likely to be important both for maintaining cell integrity and for promoting longevity...
  23. ncbi request reprint The biological sciences section program at the 60th Annual Meeting of the Gerontological Society of America
    Rita B Effros
    Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1732, USA
    J Gerontol A Biol Sci Med Sci 63:331-7. 2008
    ..Novel animal models, including those showing no evidence of aging, as well as ethical and political implications of embryonic stem cells and alternative medicine are also discussed...
  24. pmc Age- and calorie-independent life span extension from dietary restriction by bacterial deprivation in Caenorhabditis elegans
    Erica D Smith
    Department of Pathology, University of Washington, Seattle, WA 98195, USA
    BMC Dev Biol 8:49. 2008
    ..Dietary restriction (DR) increases life span and delays age-associated disease in many organisms. The mechanism by which DR enhances longevity is not well understood...
  25. doi request reprint The ongoing saga of sirtuins and aging
    Matt Kaeberlein
    Department of Pathology, University of Washington, Seattle, WA 98195 7470, USA
    Cell Metab 8:4-5. 2008
    ..In this issue of Cell Metabolism, Li et al. (2008) provide evidence that SirT1 has properties consistent with both pro- and antiaging functions in mice...
  26. ncbi request reprint Protein translation, 2007
    Matt Kaeberlein
    Department of Pathology, University of Washington, Seattle, WA 98195 7470, USA
    Aging Cell 6:731-4. 2007
    ..This Hot Topic article discusses papers published in the last year related to the importance of translation and its regulation by signaling through the target of rapamycin kinase, in modulating aging and age-associated diseases...
  27. pmc Molecular basis of ageing
    Matt Kaeberlein
    Department of Pathology, University of Washington, Seattle, Washington 98195, USA
    EMBO Rep 8:907-11. 2007
  28. ncbi request reprint Aging-related research in the "-omics" age
    Matt Kaeberlein
    Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA
    Sci Aging Knowledge Environ 2004:pe39. 2004
    ..A meta-analysis of data derived from genome-wide studies of aging in simple eukaryotes will allow the identification of conserved determinants of longevity that can be tested in mammals...
  29. ncbi request reprint Large-scale identification in yeast of conserved ageing genes
    Matt Kaeberlein
    Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA
    Mech Ageing Dev 126:17-21. 2005
    ....
  30. ncbi request reprint Genes determining yeast replicative life span in a long-lived genetic background
    Matt Kaeberlein
    Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA
    Mech Ageing Dev 126:491-504. 2005
    ..These results define a limited number of genes likely to regulate replicative life span in a strain-independent manner, and create a basis for future epistasis analysis to determine genetic pathways of aging...
  31. ncbi request reprint Regulation of yeast replicative life span by TOR and Sch9 in response to nutrients
    Matt Kaeberlein
    Departments of Genome Sciences and Medicine, University of Washington, Seattle, WA 98195, USA
    Science 310:1193-6. 2005
    ..We propose that the TOR and Sch9 kinases define a primary conduit through which excess nutrient intake limits longevity in yeast...
  32. pmc Extension of chronological life span in yeast by decreased TOR pathway signaling
    R Wilson Powers
    Department of Genome Sciences and Medicine, The Howard Hughes Medical Institute, University of Washington, Seattle, Washington 98195, USA
    Genes Dev 20:174-84. 2006
    ..We propose that up-regulation of a highly conserved response to starvation-induced stress is important for life span extension by decreased TOR signaling in yeast and higher eukaryotes...
  33. pmc Genome-wide approaches to understanding human ageing
    Matt Kaeberlein
    Department of Pathology, University of Washington, Seattle, WA 98195, USA
    Hum Genomics 2:422-8. 2006
    ....
  34. ncbi request reprint Medicine: grapes versus gluttony
    Matt Kaeberlein
    Nature 444:280-1. 2006
  35. ncbi request reprint Genome-wide identification of conserved longevity genes in yeast and worms
    Erica D Smith
    Department of Biochemistry, University of Washington, Seattle, WA 98195, USA
    Mech Ageing Dev 128:106-11. 2007
    ..Here we compare and contrast the results from genome-wide aging screens and assess the likelihood that there are "public" aging mechanisms...
  36. pmc The sensitivity of yeast mutants to oleic acid implicates the peroxisome and other processes in membrane function
    Daniel Lockshon
    Department of Biochemistry, University of Washington, Seattle, Washington 98195, USA
    Genetics 175:77-91. 2007
    ..We propose that yeast deficient in peroxisomal and other functions are sensitive to oleate perhaps because of an inability to effectively control the fatty acid composition of membrane phospholipids...
  37. doi request reprint Cell biology: A molecular age barrier
    Matt Kaeberlein
    Nature 454:709-10. 2008