Ashu Johri

Summary

Publications

  1. pmc Hunting-ton for new proteases: MMPs as the new target?
    Ashu Johri
    Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York, NY 10065, USA
    Neuron 67:171-3. 2010
  2. pmc PGC-1α, mitochondrial dysfunction, and Huntington's disease
    Ashu Johri
    Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York Presbyterian Hospital, New York, NY 10065, USA
    Free Radic Biol Med 62:37-46. 2013
  3. pmc Antioxidants in Huntington's disease
    Ashu Johri
    Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York Presbyterian Hospital, New York, NY 10065, USA
    Biochim Biophys Acta 1822:664-74. 2012
  4. doi request reprint Muscling in on PGC-1α for improved quality of life in ALS
    Ashu Johri
    Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York Presbyterian Hospital, New York, NY 10065, USA
    Cell Metab 15:567-9. 2012
  5. pmc Pharmacologic activation of mitochondrial biogenesis exerts widespread beneficial effects in a transgenic mouse model of Huntington's disease
    Ashu Johri
    Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York Presbyterian Hospital, New York, NY 10065, USA
    Hum Mol Genet 21:1124-37. 2012
  6. pmc Truncated peroxisome proliferator-activated receptor-γ coactivator 1α splice variant is severely altered in Huntington's disease
    Ashu Johri
    Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York, NY 10065, USA asj2002 med cornell edu
    Neurodegener Dis 8:496-503. 2011
  7. pmc Transducer of regulated CREB-binding proteins (TORCs) transcription and function is impaired in Huntington's disease
    Rajnish Kumar Chaturvedi
    Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York Presbyterian Hospital, New York, NY 10065, USA
    Hum Mol Genet 21:3474-88. 2012
  8. pmc Concordant signaling pathways produced by pesticide exposure in mice correspond to pathways identified in human Parkinson's disease
    Seema Gollamudi
    Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York, New York, United States of America
    PLoS ONE 7:e36191. 2012
  9. pmc Enhanced mitochondrial biogenesis ameliorates disease phenotype in a full-length mouse model of Huntington's disease
    Abhishek Chandra
    Feil Family Brain and Mind Research Institute, Weill Cornell Medical College, New York, NY 10065, USA
    Hum Mol Genet 25:2269-2282. 2016
  10. pmc Impairment of PGC-1alpha expression, neuropathology and hepatic steatosis in a transgenic mouse model of Huntington's disease following chronic energy deprivation
    Rajnish K Chaturvedi
    Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York, NY 10065, USA
    Hum Mol Genet 19:3190-205. 2010

Collaborators

  • M Flint Beal
  • Ferdinando Squitieri
  • Anatoly A Starkov
  • M Flint Beal
  • Abhishek Chandra
  • Noel Y Calingasan
  • Seema Gollamudi
  • Rajnish Kumar Chaturvedi
  • Lichuan Yang
  • Thomas Hennessey
  • Rajnish K Chaturvedi
  • Joshua M White
  • Yevgeniya Shurubor
  • Abhijeet Sharma
  • X William Yang
  • Olivier Elemento
  • Swati Agarwal
  • Divya Mishra
  • Shashi Kant Tiwari
  • Yoon Seong Kim

Detail Information

Publications12

  1. pmc Hunting-ton for new proteases: MMPs as the new target?
    Ashu Johri
    Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York, NY 10065, USA
    Neuron 67:171-3. 2010
    ..These findings provide new insights into huntingtin proteolysis and its potential as a therapeutic target...
  2. pmc PGC-1α, mitochondrial dysfunction, and Huntington's disease
    Ashu Johri
    Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York Presbyterian Hospital, New York, NY 10065, USA
    Free Radic Biol Med 62:37-46. 2013
    ..Here we have attempted to discuss in a nutshell, the key findings on the role of PGC-1α in mitochondrial dysfunction in HD and its potential as a therapeutic target to cure HD. ..
  3. pmc Antioxidants in Huntington's disease
    Ashu Johri
    Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York Presbyterian Hospital, New York, NY 10065, USA
    Biochim Biophys Acta 1822:664-74. 2012
    ..This article is part of a Special Issue entitled: Antioxidants and Antioxidant Treatment in Disease...
  4. doi request reprint Muscling in on PGC-1α for improved quality of life in ALS
    Ashu Johri
    Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York Presbyterian Hospital, New York, NY 10065, USA
    Cell Metab 15:567-9. 2012
    ..In this issue, Da Cruz et al. (2012) show improved muscle function, but not survival, with increased PGC-1α activity in muscle in a mouse model of amyotrophic lateral sclerosis...
  5. pmc Pharmacologic activation of mitochondrial biogenesis exerts widespread beneficial effects in a transgenic mouse model of Huntington's disease
    Ashu Johri
    Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York Presbyterian Hospital, New York, NY 10065, USA
    Hum Mol Genet 21:1124-37. 2012
    ..These findings provide strong evidence that treatment with bezafibrate exerts neuroprotective effects which may be beneficial in the treatment of HD...
  6. pmc Truncated peroxisome proliferator-activated receptor-γ coactivator 1α splice variant is severely altered in Huntington's disease
    Ashu Johri
    Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York, NY 10065, USA asj2002 med cornell edu
    Neurodegener Dis 8:496-503. 2011
    ..The N-truncated splice variant of PGC1α (NT-PGC1α) is produced in tissues, but the role of truncated splice variants of PGC1α in HD and in the regulation of mitochondrial gene expression has not been elucidated...
  7. pmc Transducer of regulated CREB-binding proteins (TORCs) transcription and function is impaired in Huntington's disease
    Rajnish Kumar Chaturvedi
    Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York Presbyterian Hospital, New York, NY 10065, USA
    Hum Mol Genet 21:3474-88. 2012
    ..These findings show that impaired expression and function of TORC1, which results in a reduction in PGC-1α, plays an important role in mitochondrial dysfunction in HD...
  8. pmc Concordant signaling pathways produced by pesticide exposure in mice correspond to pathways identified in human Parkinson's disease
    Seema Gollamudi
    Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York, New York, United States of America
    PLoS ONE 7:e36191. 2012
    ..The analysis of these networks and pathways may therefore lead to improved understanding of disease pathogenesis, and potential novel therapeutic targets...
  9. pmc Enhanced mitochondrial biogenesis ameliorates disease phenotype in a full-length mouse model of Huntington's disease
    Abhishek Chandra
    Feil Family Brain and Mind Research Institute, Weill Cornell Medical College, New York, NY 10065, USA
    Hum Mol Genet 25:2269-2282. 2016
    ....
  10. pmc Impairment of PGC-1alpha expression, neuropathology and hepatic steatosis in a transgenic mouse model of Huntington's disease following chronic energy deprivation
    Rajnish K Chaturvedi
    Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York, NY 10065, USA
    Hum Mol Genet 19:3190-205. 2010
    ....
  11. pmc Mitochondrial dysfunction in neurodegenerative diseases
    Ashu Johri
    Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York, NY, USA
    J Pharmacol Exp Ther 342:619-30. 2012
    ..Here, we provide a concise overview of the major findings in recent years highlighting the importance of healthy mitochondria for a healthy neuron...
  12. pmc Prospects for neuroprotective therapies in prodromal Huntington's disease
    Abhishek Chandra
    Brain and Mind Research Institute, Weill Medical College of Cornell University, New York Presbyterian Hospital, New York, New York, USA
    Mov Disord 29:285-93. 2014
    ..We review both the earliest detectable clinical and laboratory manifestations of HD, as well as potential neuroprotective therapies that could be utilized in presymptomatic HD...