Wayel Jassem

Summary

Publications

  1. ncbi The role of mitochondria in ischemia/reperfusion injury in organ transplantation
    Wayel Jassem
    Liver Transplant Unit, Institute of Liver Studies, King s College Hospital, Denmark Hill, London, United Kingdom
    Kidney Int 66:514-7. 2004
  2. ncbi Cadaveric versus living-donor livers: differences in inflammatory markers after transplantation
    Wayel Jassem
    Liver Transplant Unit, Institute of Liver Studies, King s College Hospital, Denmark Hill, London, UK
    Transplantation 76:1599-603. 2003
  3. ncbi Leukocyte infiltration and inflammatory antigen expression in cadaveric and living-donor livers before transplant
    Wayel Jassem
    Liver Transplant Unit, Institute of Liver Studies, King s College Hospital, Denmark Hill, London, United Kingdom
    Transplantation 75:2001-7. 2003
  4. ncbi Ischemic preconditioning of cadaver donor livers protects allografts following transplantation
    Wayel Jassem
    Liver Transplant Unit, Institute of Liver Studies, King s College Hospital, Denmark Hill, London, United Kingdom
    Transplantation 81:169-74. 2006
  5. doi Effect of ischemic preconditioning on the genomic response to reperfusion injury in deceased donor liver transplantation
    Wayel Jassem
    Liver Transplant Unit, Institute of Liver Studies, King s College Hospital, London, United Kingdom
    Liver Transpl 15:1750-65. 2009
  6. pmc Single-center experience with liver transplantation from controlled non-heartbeating donors: a viable source of grafts
    Paolo Muiesan
    Department of Liver Transplantation and HPB Surgery, King s College Hospital, London, UK
    Ann Surg 242:732-8. 2005
  7. doi Biliary complications after liver transplantation using grafts from donors after cardiac death: results from a matched control study in a single large volume center
    Michelle L DeOliveira
    King s College Hospital, Division of Liver Transplantation and HPB Surgery Institute for Liver Diseases, London, UK
    Ann Surg 254:716-22; discussion 722-3. 2011
  8. doi Presentation, diagnosis, and management of early hepatic venous outflow complications in whole cadaveric liver transplant
    Shirin Elizabeth Khorsandi
    Institute of Liver Studies, King s College Hospital, London, United Kingdom
    Liver Transpl 21:914-21. 2015
  9. pmc The microRNA Expression Profile in Donation after Cardiac Death (DCD) Livers and Its Ability to Identify Primary Non Function
    Shirin Elizabeth Khorsandi
    Institute of Liver Studies, King s College Hospital, London, United Kingdom
    PLoS ONE 10:e0127073. 2015
  10. pmc The Impact of Ischemia/Reperfusion Injury on Liver Allografts from Deceased after Cardiac Death versus Deceased after Brain Death Donors
    Jin Xu
    Liver Transplant Unit, Institute of Liver Studies, King s College Hospital, London, United Kingdom
    PLoS ONE 11:e0148815. 2016

Collaborators

Detail Information

Publications23

  1. ncbi The role of mitochondria in ischemia/reperfusion injury in organ transplantation
    Wayel Jassem
    Liver Transplant Unit, Institute of Liver Studies, King s College Hospital, Denmark Hill, London, United Kingdom
    Kidney Int 66:514-7. 2004
    ..In this context, mitochondria may be critical organelles, since they undergo major changes that may contribute to the injury occurring during I/R...
  2. ncbi Cadaveric versus living-donor livers: differences in inflammatory markers after transplantation
    Wayel Jassem
    Liver Transplant Unit, Institute of Liver Studies, King s College Hospital, Denmark Hill, London, UK
    Transplantation 76:1599-603. 2003
    ..The aim of this study was to investigate whether organs from living donors experience less damage upon reperfusion than those retrieved from cadaver donors, where cold ischemia times are significantly longer...
  3. ncbi Leukocyte infiltration and inflammatory antigen expression in cadaveric and living-donor livers before transplant
    Wayel Jassem
    Liver Transplant Unit, Institute of Liver Studies, King s College Hospital, Denmark Hill, London, United Kingdom
    Transplantation 75:2001-7. 2003
    ....
  4. ncbi Ischemic preconditioning of cadaver donor livers protects allografts following transplantation
    Wayel Jassem
    Liver Transplant Unit, Institute of Liver Studies, King s College Hospital, Denmark Hill, London, United Kingdom
    Transplantation 81:169-74. 2006
    ..The aim of this clinical study is to investigate whether IP of cadaver livers prior to retrieval confers protection on the allografts...
  5. doi Effect of ischemic preconditioning on the genomic response to reperfusion injury in deceased donor liver transplantation
    Wayel Jassem
    Liver Transplant Unit, Institute of Liver Studies, King s College Hospital, London, United Kingdom
    Liver Transpl 15:1750-65. 2009
    ..IP protection of liver allografts was associated with a reduction in the expression of immune response genes and promotion of those involved in protection and repair...
  6. pmc Single-center experience with liver transplantation from controlled non-heartbeating donors: a viable source of grafts
    Paolo Muiesan
    Department of Liver Transplantation and HPB Surgery, King s College Hospital, London, UK
    Ann Surg 242:732-8. 2005
    ..To increase the number of livers available for transplantation a non-heartbeating donor (NHBD) liver transplant program was started after obtaining hospital ethical committee approval...
  7. doi Biliary complications after liver transplantation using grafts from donors after cardiac death: results from a matched control study in a single large volume center
    Michelle L DeOliveira
    King s College Hospital, Division of Liver Transplantation and HPB Surgery Institute for Liver Diseases, London, UK
    Ann Surg 254:716-22; discussion 722-3. 2011
    ..To assess the incidence and impact of biliary complications in recipients transplanted from donors after cardiac death (DCD) at one single large institution...
  8. doi Presentation, diagnosis, and management of early hepatic venous outflow complications in whole cadaveric liver transplant
    Shirin Elizabeth Khorsandi
    Institute of Liver Studies, King s College Hospital, London, United Kingdom
    Liver Transpl 21:914-21. 2015
    ..11). However, early revisional surgery for HVOO can preserve graft function with retransplantation being reserved for when surgical cavoplasty or radiological stenting is technically not possible...
  9. pmc The microRNA Expression Profile in Donation after Cardiac Death (DCD) Livers and Its Ability to Identify Primary Non Function
    Shirin Elizabeth Khorsandi
    Institute of Liver Studies, King s College Hospital, London, United Kingdom
    PLoS ONE 10:e0127073. 2015
    ..In conclusion, microRNA expression patterns have a low diagnostic potential clinically in discriminating DCD liver quality and outcome. ..
  10. pmc The Impact of Ischemia/Reperfusion Injury on Liver Allografts from Deceased after Cardiac Death versus Deceased after Brain Death Donors
    Jin Xu
    Liver Transplant Unit, Institute of Liver Studies, King s College Hospital, London, United Kingdom
    PLoS ONE 11:e0148815. 2016
    ..Using livers obtained from DCD versus donors after brain death (DBD), we aimed to understand how ischemia/reperfusion (I/R) injury alters expression of pro-inflammatory markers ceramides and influences graft leukocyte infiltration...
  11. doi Does Donation After Cardiac Death Utilization Adversely Affect Hepatocellular Cancer Survival?
    Shirin Elizabeth Khorsandi
    1 Institute of Liver Studies, King s College Hospital, London, United Kingdom
    Transplantation 100:1916-24. 2016
    ..There are concerns that this approach may oncologically disadvantage HCC recipients. The aim of this study was to determine whether DCD transplantation was associated with poorer cancer-related survival in HCC...
  12. pmc Impact of Donation Mode on the Proportion and Function of T Lymphocytes in the Liver
    Emmanuel Xystrakis
    Institute of Liver Studies, Faculty of Life Sciences and Medicine, King s College London at King s College Hospital, London, United Kingdom
    PLoS ONE 10:e0139791. 2015
    ..The mode of liver donation alters various metabolic and inflammatory pathways but the way it affects intrahepatic T-cells is still unclear...
  13. doi The effect of anterograde persufflation on energy charge and hepatocyte function in donation after cardiac death livers unsuitable for transplant
    Shirin Elizabeth Khorsandi
    Institute of Liver Studies, King s College Hospital, London, United Kingdom
    Liver Transpl 20:698-704. 2014
    ..045 to 1.19 ± 0.55 (P < 0.001) and SRB from 2.53 ± 0.12 to 3.2 ± 0.95 (P < 0.001). In conclusion, A-PSF can improve the EC and function of isolated hepatocytes from DCD livers with <30% steatosis...
  14. ncbi Non-heart-beating versus cadaveric and living-donor livers: differences in inflammatory markers before transplantation
    Wayel Jassem
    Liver Transplant Unit, Institute of Liver Studies, King s College Hospital, Denmark Hill, London, United Kingdom
    Transplantation 75:1386-90. 2003
    ..The aim of this study was to assess intragraft cell populations and inflammatory markers in NHBD and to compare the findings with cadaveric and living-related donor (LRD) livers...
  15. pmc The effect of body position on compartmental intra-abdominal pressure following liver transplantation
    Adrian B Cresswell
    Liver Transplant Surgical Service and Liver Intensive Care Unit, Kings College London, Institute of Liver Studies, King s College Hospital, Denmark Hill, SE5 9RS, London, UK
    Ann Intensive Care 2:S12. 2012
    ..The abdominal contents are, however, a heterogeneous mix of solid, liquid and gas, and pressure transmission may not be uniform. The current study examines the upper and lower IAP following liver transplantation...
  16. doi Cholangiocarcinoma complicating recurrent primary sclerosing cholangitis after liver transplantation
    Shirin E Khorsandi
    Liver Institute, King s College Hospital, Denmark Hill, London, UK
    Transpl Int 24:e93-6. 2011
    ..This case report reviews the literature and highlights the need to consider cholangiocarcinoma in transplanted patients with PSC that clinically/biochemically deteriorate...
  17. doi Patients with acute-on-chronic liver failure have increased numbers of regulatory immune cells expressing the receptor tyrosine kinase MERTK
    Christine Bernsmeier
    Institute of Liver Studies, King s College Hospital, King s College London, United Kingdom
    Gastroenterology 148:603-615.e14. 2015
    ..We investigated whether MERTK expression is altered on monocytes from patients with liver failure...
  18. doi Secretory leukocyte protease inhibitor: a pivotal mediator of anti-inflammatory responses in acetaminophen-induced acute liver failure
    Charalambos Gustav Antoniades
    Section of Hepatology, St Mary s Hospital, Imperial College, London, UK Institute of Liver Sciences, King s College London, London, UK
    Hepatology 59:1564-76. 2014
    ..Culture of healthy monocytes with AALF liver homogenates, plasma, or rhSLPI induced monocytes with strikingly similar anti-inflammatory characteristics which were reversed by inhibiting the activity of SLPI...
  19. ncbi Metastatic pulmonary adenocarcinoma 6 years after curative resection for ampullary adenocarcinoma. Metastatic disease from initial primary or metachronous tumour?
    Alexandros Giakoustidis
    Institute of Liver Studies, King s College Hospital, London, United Kingdom
    JOP 12:32-6. 2011
    ..With patients surviving longer after pancreatic resection, the challenges now is the management of the unresolved longer-term issues...
  20. ncbi The role of mitochondria in ischemia/reperfusion injury
    Wayel Jassem
    Liver Transplant Unit, Institute of Liver Studies, King s College Hospital, Denmark Hill, London, SE5 9RS, United Kingdom
    Transplantation 73:493-9. 2002
    ..In this review, we examine the role of mitochondria in ischemia/reperfusion injury and the possible mechanisms that may contribute to organ dysfunction...
  21. pmc Lipidomics comparing DCD and DBD liver allografts uncovers lysophospholipids elevated in recipients undergoing early allograft dysfunction
    Jin Xu
    Faculty of Life Sciences and Medicine, King s College London, London, United Kingdom
    Sci Rep 5:17737. 2015
    ..These findings suggest that LysoPC (16:0) and LysoPC (18:0) might have a role in signalling liver tissue damage due to warm ischemia before transplantation...
  22. pmc Multivariate metabotyping of plasma predicts survival in patients with decompensated cirrhosis
    Mark J W McPhail
    Division of Digestive Health, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, 10th Floor QEQM Wing, St Mary s Hospital Campus, South Wharf Street, London NW1 2NY, United Kingdom Institute of Liver Studies, King s College Hospital, Denmark Hill, London SE19 2RS, United Kingdom
    J Hepatol 64:1058-67. 2016
    ..We investigated whether high-resolution metabolic profiling can determine a metabolic phenotype associated with 90-day survival...
  23. pmc Character and temporal evolution of apoptosis in acetaminophen-induced acute liver failure*
    Lucia A Possamai
    1Department of Hepatology, Imperial College London, London, UK 2Institute of Liver Studies at King s College School of Medicine at King s College Hospital, London, UK 3Institute of Human Health and Performance, University College London, London, UK 4Department of Asthma Allergy and Lung Biology, King s College London, London, UK 5Division of Critical Care Medicine, University of Alberta, Edmonton, Canada
    Crit Care Med 41:2543-50. 2013
    ..To evaluate the role of hepatocellular and extrahepatic apoptosis during the evolution of acetaminophen-induced acute liver failure...