Kunio Yui

Summary

Country: Japan

Publications

  1. ncbi request reprint Competitive Interaction Between Plasma Omega-3 Fatty Acids and Arachidonic Acid is Related to Down-Regulation of A Signaling Mediator
    Kunio Yui
    Research Institute of Pervasive Developmental Disorders, Ashiya University, 13 22 Rokurokusocho, Ashiya, 659 8511, Hyogo, Japan
    Med Chem 12:318-27. 2016
  2. ncbi request reprint Oxidative Stress and Nitric Oxide in Autism Spectrum Disorder and Other Neuropsychiatric Disorders
    Kunio Yui
    Research Institute of Pervasive Developmental Disorders, Ashiya University, 13 22 Rokurokusocho, Ashiya, 659 8511, Hyogo, Japan
    CNS Neurol Disord Drug Targets 15:587-96. 2016
  3. doi request reprint Reduced endogenous urinary total antioxidant power and its relation of plasma antioxidant activity of superoxide dismutase in individuals with autism spectrum disorder
    Kunio Yui
    Department of Pediatrics, Dokkyo Medical University, 880 Kitakobayashi, Mibu 321 0293, Tochigi, Japan Department of Drug Evaluation and Informatics, School of Pharmaceutical Science, University of Shizuoka, Shizuoka 422 8526, Japan Electronic address
    Int J Dev Neurosci . 2016
  4. pmc Eicosanoids Derived From Arachidonic Acid and Their Family Prostaglandins and Cyclooxygenase in Psychiatric Disorders
    Kunio Yui
    Research Institute of Pervasive Developmental Disorders, Ashiya University Graduate School of Education Rokurokusocho 13 22, Ashiya 659 8511, Hyogo, Japan
    Curr Neuropharmacol 13:776-85. 2015
  5. doi request reprint Down-regulation of a signaling mediator in association with lowered plasma arachidonic acid levels in individuals with autism spectrum disorders
    Kunio Yui
    Research Institute of Pervasive Developmental Disorders, Ashiya University, 13 22 Rokurokusocho, Ashiya, 659 8511 Hyogo, Japan Electronic address
    Neurosci Lett 610:223-8. 2016
  6. doi request reprint Increased ω-3 polyunsaturated fatty acid/arachidonic acid ratios and upregulation of signaling mediator in individuals with autism spectrum disorders
    Kunio Yui
    Research Institute of Pervasive Developmental Disorders, Ashiya University, 13 22 Rokurokusocho, Ashiya 659 8511, Hyogo, Japan Electronic address
    Life Sci 145:205-12. 2016
  7. ncbi request reprint Mitochondrial Dysfunction and Its Relationship with mTOR Signaling and Oxidative Damage in Autism Spectrum Disorders
    Kunio Yui
    Research Institute of Pervasive Developmental Disorders, Ashiya University Graduate School of Education, Ashiya 659 8511, Japan
    Mini Rev Med Chem 15:373-89. 2015
  8. doi request reprint Effects of large doses of arachidonic acid added to docosahexaenoic acid on social impairment in individuals with autism spectrum disorders: a double-blind, placebo-controlled, randomized trial
    Kunio Yui
    Research Institute of Progressive Developmental Disorders, Ashiya University Graduate School of Education, Ashiya, Japan
    J Clin Psychopharmacol 32:200-6. 2012
  9. ncbi request reprint [Therapeutic effects of larger doses of arachidonic acid added to DHA on social impairment and its relation to alterations of polyunsaturated fatty acids in individuals with autism spectrum disorders]
    Kunio Yui
    Research Institute of Pervasive Developmental Disorders, 13 22 Rokurokuso machi, Ashiya 659 8511, Japan
    Nihon Shinkei Seishin Yakurigaku Zasshi 31:117-24. 2011
  10. ncbi request reprint Psycho-Cognitive Intervention for ASD from Cross-Species Behavioral Analyses of Infants, Chicks and Common Marmosets
    Mamiko Koshiba
    Department of Pediatrics, Faculty of Medicine, Saitama Medical University, 38 Morohongo, Moroyama cho, Iruma gun, 350 0495 Saitama, Japan
    CNS Neurol Disord Drug Targets 15:578-86. 2016

Collaborators

  • Mamiko Koshiba
  • Shun Nakamura
  • Koki Mimura
  • Genta Karino
  • Tetsuya Kunikata
  • Hideo Yamanouchi

Detail Information

Publications11

  1. ncbi request reprint Competitive Interaction Between Plasma Omega-3 Fatty Acids and Arachidonic Acid is Related to Down-Regulation of A Signaling Mediator
    Kunio Yui
    Research Institute of Pervasive Developmental Disorders, Ashiya University, 13 22 Rokurokusocho, Ashiya, 659 8511, Hyogo, Japan
    Med Chem 12:318-27. 2016
    ..These findings suggested that increased plasma DHA/AA ratio may be related to lower plasma levels of ceruloplasmin, which may contribute to the pathophysiology of behavioral symptoms in 30 individuals with ASD. ..
  2. ncbi request reprint Oxidative Stress and Nitric Oxide in Autism Spectrum Disorder and Other Neuropsychiatric Disorders
    Kunio Yui
    Research Institute of Pervasive Developmental Disorders, Ashiya University, 13 22 Rokurokusocho, Ashiya, 659 8511, Hyogo, Japan
    CNS Neurol Disord Drug Targets 15:587-96. 2016
    ..Therefore, the NO system could provide useful drug targets for these diseases. NO and NO donors also show therapeutic potential for Alzheimer's disease and schizophrenia with refractory symptoms and cognitive dysfunction. ..
  3. doi request reprint Reduced endogenous urinary total antioxidant power and its relation of plasma antioxidant activity of superoxide dismutase in individuals with autism spectrum disorder
    Kunio Yui
    Department of Pediatrics, Dokkyo Medical University, 880 Kitakobayashi, Mibu 321 0293, Tochigi, Japan Department of Drug Evaluation and Informatics, School of Pharmaceutical Science, University of Shizuoka, Shizuoka 422 8526, Japan Electronic address
    Int J Dev Neurosci . 2016
    ..The endogenous antioxidant capacity may be deficient without altered urinary HEL and 8-OHdG levels in individuals with ASD. The plasma SOD levels may be related to reduced endogenous antioxidant capacity...
  4. pmc Eicosanoids Derived From Arachidonic Acid and Their Family Prostaglandins and Cyclooxygenase in Psychiatric Disorders
    Kunio Yui
    Research Institute of Pervasive Developmental Disorders, Ashiya University Graduate School of Education Rokurokusocho 13 22, Ashiya 659 8511, Hyogo, Japan
    Curr Neuropharmacol 13:776-85. 2015
    ..COX-2 is typically induced by inflammatory stimuli in the majority of tissues, and the only isoform responsible for propagating the inflammatory response. Thus, COX-2 inhibitors considered as the best target for Alzheimer's disease. ..
  5. doi request reprint Down-regulation of a signaling mediator in association with lowered plasma arachidonic acid levels in individuals with autism spectrum disorders
    Kunio Yui
    Research Institute of Pervasive Developmental Disorders, Ashiya University, 13 22 Rokurokusocho, Ashiya, 659 8511 Hyogo, Japan Electronic address
    Neurosci Lett 610:223-8. 2016
    ..These findings suggest that reduced plasma AA levels may downregulate Cp...
  6. doi request reprint Increased ω-3 polyunsaturated fatty acid/arachidonic acid ratios and upregulation of signaling mediator in individuals with autism spectrum disorders
    Kunio Yui
    Research Institute of Pervasive Developmental Disorders, Ashiya University, 13 22 Rokurokusocho, Ashiya 659 8511, Hyogo, Japan Electronic address
    Life Sci 145:205-12. 2016
    ..The investigation of links between the ratio of omega-3/omega-6 PUFAs and neuronal signaling is a research priority in autism spectrum disorders (ASD)...
  7. ncbi request reprint Mitochondrial Dysfunction and Its Relationship with mTOR Signaling and Oxidative Damage in Autism Spectrum Disorders
    Kunio Yui
    Research Institute of Pervasive Developmental Disorders, Ashiya University Graduate School of Education, Ashiya 659 8511, Japan
    Mini Rev Med Chem 15:373-89. 2015
    ..Finally, a decrease in total antioxidant capacity may account for ASD children who show core social and behavioral impairments without neurological and somatic symptoms. ..
  8. doi request reprint Effects of large doses of arachidonic acid added to docosahexaenoic acid on social impairment in individuals with autism spectrum disorders: a double-blind, placebo-controlled, randomized trial
    Kunio Yui
    Research Institute of Progressive Developmental Disorders, Ashiya University Graduate School of Education, Ashiya, Japan
    J Clin Psychopharmacol 32:200-6. 2012
    ..This preliminary study suggests that supplementation with larger ARA doses added to DHA improves impaired social interaction in individuals with autism spectrum disorder by up-regulating signal transduction...
  9. ncbi request reprint [Therapeutic effects of larger doses of arachidonic acid added to DHA on social impairment and its relation to alterations of polyunsaturated fatty acids in individuals with autism spectrum disorders]
    Kunio Yui
    Research Institute of Pervasive Developmental Disorders, 13 22 Rokurokuso machi, Ashiya 659 8511, Japan
    Nihon Shinkei Seishin Yakurigaku Zasshi 31:117-24. 2011
    ..The present clinical trials suggest that supplementation with larger ARA doses added to DHA improves social impairment in individuals with ASD via ARA-induced upregulation of neuronal functioning...
  10. ncbi request reprint Psycho-Cognitive Intervention for ASD from Cross-Species Behavioral Analyses of Infants, Chicks and Common Marmosets
    Mamiko Koshiba
    Department of Pediatrics, Faculty of Medicine, Saitama Medical University, 38 Morohongo, Moroyama cho, Iruma gun, 350 0495 Saitama, Japan
    CNS Neurol Disord Drug Targets 15:578-86. 2016
    ....
  11. ncbi request reprint [Useful pharmacologic treatment in impaired social interaction in autism spectrum disorders]
    Kunio Yui
    Research Institute of Pervasive Developmental Disorders, Graduate School of Education, Ashiya University
    Seishin Shinkeigaku Zasshi 114:934-40. 2012
    ..Environmental chemicals can affect the development of the brain. Further studies will be required to address the effect of environmental chemicals...