Keitaro Yokoyama

Summary

Country: Japan

Publications

  1. ncbi request reprint An intron 4 gene polymorphism in endothelial cell nitric oxide synthase might modulate volume-dependent hypertension in patients on hemodialysis
    K Yokoyama
    Internal Medicine II, Jikei University School of Medicine, Tokyo, Japan
    Nephron 85:232-7. 2000
  2. ncbi request reprint Vitamin D receptor gene polymorphism detected by digestion with Apa I influences the parathyroid response to extracellular calcium in Japanese chronic dialysis patients
    K Yokoyama
    Division of Nephrology and Hypertension, Jikei University School of Medicine, Tokyo, Japan
    Nephron 89:315-20. 2001
  3. ncbi request reprint Calcium-sensing receptor gene polymorphism affects the parathyroid response to moderate hypercalcemic suppression in patients with end-stage renal disease
    K Yokoyama
    The Division of Nephrology and Hypertension, Jikei University School of Medicine, Tokyo, Japan
    Clin Nephrol 57:131-5. 2002
  4. ncbi request reprint Plasma pteridine concentrations in patients with chronic renal failure
    Keitaro Yokoyama
    The Division of Nephrology and Hypertension, Jikei University School of Medicine, Tokyo, Japan
    Nephrol Dial Transplant 17:1032-6. 2002
  5. ncbi request reprint The negative Ca(2+) balance is involved in the stimulation of PTH secretion
    Keitaro Yokoyama
    Division of Nephrology and Hypertension, Jikei University School of Medicine, Tokyo, Japan
    Nephron 92:86-90. 2002
  6. doi request reprint Dihydropyridine- and voltage-sensitive Ca2+ entry in human parathyroid cells
    Keitaro Yokoyama
    Department of Nephrology and Hypertension, The Jikei University School of Medicine, 3 25 8 Nishishinbashi, Minato ku, Tokyo 105 8461, Japan
    Exp Physiol 94:847-55. 2009
  7. doi request reprint 33 Years of Peritoneal Dialysis-Associated Peritonitis: A Single-Center Study in Japan
    Masatsugu Nakao
    Division of Nephrology and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan
    Ther Apher Dial 20:60-5. 2016
  8. ncbi request reprint Risk factors and preventive measures for encapsulating peritoneal sclerosis--Jikei experience 2002
    Masaaki Nakayama
    Division of Kidney and Hypertension, Tokyo Jikei University School of Medicine, Tokyo, Japan
    Adv Perit Dial 18:144-8. 2002
  9. ncbi request reprint Risk factors for encapsulating peritoneal sclerosis in patients who have experienced peritoneal dialysis treatment
    Ryo Yamamoto
    Department of Kidney and Hypertension, The Jikei University School of Medicine, 3 25 8 Nishishinbashi, Minato ku, Tokyo 105 8461, Japan
    Clin Exp Nephrol 9:148-52. 2005
  10. ncbi request reprint The influences of method of calcium correction and the timing of blood collection on application of the K/DOQI Clinical Practice Guidelines for Bone Metabolism and Disease in Japan
    Keitaro Yokoyama
    Division of Kidney and Hypertension, Jikei University of Medicine, Tokyo, Japan
    Ther Apher Dial 10:257-61. 2006

Detail Information

Publications127 found, 100 shown here

  1. ncbi request reprint An intron 4 gene polymorphism in endothelial cell nitric oxide synthase might modulate volume-dependent hypertension in patients on hemodialysis
    K Yokoyama
    Internal Medicine II, Jikei University School of Medicine, Tokyo, Japan
    Nephron 85:232-7. 2000
    ....
  2. ncbi request reprint Vitamin D receptor gene polymorphism detected by digestion with Apa I influences the parathyroid response to extracellular calcium in Japanese chronic dialysis patients
    K Yokoyama
    Division of Nephrology and Hypertension, Jikei University School of Medicine, Tokyo, Japan
    Nephron 89:315-20. 2001
    ..In the present study, we have investigated the relationship between the parathyroid responsiveness and VDR gene polymorphism, as detected by the Apa I restriction enzyme, by changing the concentration of Ca2+ in the dialysate...
  3. ncbi request reprint Calcium-sensing receptor gene polymorphism affects the parathyroid response to moderate hypercalcemic suppression in patients with end-stage renal disease
    K Yokoyama
    The Division of Nephrology and Hypertension, Jikei University School of Medicine, Tokyo, Japan
    Clin Nephrol 57:131-5. 2002
    ..A rightward shift of the calcium set-point and an increase of the minimum secretion rate have been found in secondary hyperparathyroidism, indicating abnormal calcium sensing...
  4. ncbi request reprint Plasma pteridine concentrations in patients with chronic renal failure
    Keitaro Yokoyama
    The Division of Nephrology and Hypertension, Jikei University School of Medicine, Tokyo, Japan
    Nephrol Dial Transplant 17:1032-6. 2002
    ..Pteridine metabolism is impaired in the uraemic state. This may affect cardiovascular function and contribute to malnutrition. We wished to clarify further the impact of impaired pteridine metabolism...
  5. ncbi request reprint The negative Ca(2+) balance is involved in the stimulation of PTH secretion
    Keitaro Yokoyama
    Division of Nephrology and Hypertension, Jikei University School of Medicine, Tokyo, Japan
    Nephron 92:86-90. 2002
    ..This suggests that low Ca(2+) dialysate may exaggerate the progression of secondary hyperparathyroidism...
  6. doi request reprint Dihydropyridine- and voltage-sensitive Ca2+ entry in human parathyroid cells
    Keitaro Yokoyama
    Department of Nephrology and Hypertension, The Jikei University School of Medicine, 3 25 8 Nishishinbashi, Minato ku, Tokyo 105 8461, Japan
    Exp Physiol 94:847-55. 2009
    ..This Ca(2+) entry system might provide a compensatory pathway for the negative feedback regulation of parathyroid hormone secretion, especially in hyperplastic conditions in which the Ca(2+)-sensing receptor is poorly expressed...
  7. doi request reprint 33 Years of Peritoneal Dialysis-Associated Peritonitis: A Single-Center Study in Japan
    Masatsugu Nakao
    Division of Nephrology and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan
    Ther Apher Dial 20:60-5. 2016
    ..Furthermore, changes in microorganisms, antimicrobial therapies, patient education and improved PD system devices have presumably affected the reduction in the duration of peritonitis. ..
  8. ncbi request reprint Risk factors and preventive measures for encapsulating peritoneal sclerosis--Jikei experience 2002
    Masaaki Nakayama
    Division of Kidney and Hypertension, Tokyo Jikei University School of Medicine, Tokyo, Japan
    Adv Perit Dial 18:144-8. 2002
    ..Patients who remain high transporters with inflammatory reaction might require pharmacologic intervention, including prednisolone therapy. Further observations are required to validate our approach...
  9. ncbi request reprint Risk factors for encapsulating peritoneal sclerosis in patients who have experienced peritoneal dialysis treatment
    Ryo Yamamoto
    Department of Kidney and Hypertension, The Jikei University School of Medicine, 3 25 8 Nishishinbashi, Minato ku, Tokyo 105 8461, Japan
    Clin Exp Nephrol 9:148-52. 2005
    ..The present study was conducted to clarify the clinical risk factors related to the development of encapsulating peritoneal sclerosis (EPS), which is one of the most serious complications in patients undergoing peritoneal dialysis (PD)...
  10. ncbi request reprint The influences of method of calcium correction and the timing of blood collection on application of the K/DOQI Clinical Practice Guidelines for Bone Metabolism and Disease in Japan
    Keitaro Yokoyama
    Division of Kidney and Hypertension, Jikei University of Medicine, Tokyo, Japan
    Ther Apher Dial 10:257-61. 2006
    ..001). These results suggest that it is necessary to specify the timing of measurement and the method of Ca correction when guidelines for management of ROD are established in the future...
  11. doi request reprint Successful treatment of nephrotic syndrome caused by recurrent IgA nephropathy with chronic active antibody-mediated rejection three years after kidney transplantation
    Tatsuhiro Yaginuma
    Division of Kidney and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan
    Clin Transplant 25:28-33. 2011
    ..0 mg/dL. We possibly could have performed additional treatments such as rituximab and intravenous immunoglobulin for the CAAMR, but therapeutic strategies for CAAMR have not yet been established...
  12. ncbi request reprint Cinacalcet for hemodialyzed patients with or without a high PTH level to control serum calcium and phosphorus: ECO (evaluation of cinacalcet HCl outcome) study
    Keitaro Yokoyama
    Division of Kidney and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan
    Clin Nephrol 78:87-92. 2012
    ..We investigated the influence of cinacalcet on serum Ca and P in hemodialyzed patients with or without a high PTH level, according to K/DOQI guideline, to control serum Ca and P levels...
  13. ncbi request reprint Fifteen cases of encapsulating peritoneal sclerosis related to peritoneal dialysis: a single-center experience in Japan
    Hiroyasu Yamamoto
    Department of Nephrology and Hypertension, Jikei University School of Medicine, Tokyo, Japan
    Adv Perit Dial 18:135-8. 2002
    ..3%. When EPS symptoms are not ameliorated by CS and TPN, surgical treatment should be considered. To prevent EPS, high-risk patients who have more than 72 months on CAPD and who have a high-transport peritoneum should discontinue CAPD...
  14. ncbi request reprint Restoration of peritoneal integrity after withdrawal of peritoneal dialysis: characteristic features of the patients at risk of encapsulating peritoneal sclerosis
    Yasushi Otsuka
    Division of Kidney and Hypertension, Department of Internal Medicine, Jikei University School of Medicine, 3 25 8 Nishishinbashi, Tokyo 105 8461, Japan
    Clin Exp Nephrol 9:315-9. 2005
    ..Accordingly, we aimed to observe changes in peritoneal function after the stoppage of PD, and to clarify the characteristic features of the patients at risk of EPS...
  15. ncbi request reprint Effect of repeated intravenous iron administration in haemodialysis patients on serum 8-hydroxy-2'-deoxyguanosine levels
    Yukio Maruyama
    Division of Kidney and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, 3 19 18 Nishi shinbashi, Minato ku, Tokyo, 105 8471, Japan
    Nephrol Dial Transplant 22:1407-12. 2007
    ..This study aims to clarify the time course of changes in serum 8-hydroxy-2'-deoxyguanosine (8-OHdG), a marker of DNA oxidative injury, during a period of repeated IVIR administration in HD patients...
  16. doi request reprint Successful treatment of recurrent focal segmental glomerulosclerosis combined with calcineurin inhibitor nephrotoxicity four yr after kidney transplantation
    Jun Mitome
    Division of Kidney and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan
    Clin Transplant 24:48-53. 2010
    ..In the case of nephrotic syndrome after kidney transplantation, we should consider not only recurrent FSGS, but also CNI-induced nephrotoxicity to determine the optimal treatment...
  17. doi request reprint Detection of dihydropyridine- and voltage-sensitive intracellular Ca(2+) signals in normal human parathyroid cells
    Rinako Iida
    Department of Nephrology and Hypertension, Jikei University School of Medicine, 3 25 8 Nishishinbashi, Minato ku, Tokyo 105 8461, Japan
    J Physiol Sci 63:235-40. 2013
    ..This system might provide a compensatory pathway for negative feedback regulation of parathyroid hormone secretion under physiological conditions. ..
  18. ncbi request reprint Surgical verification of percutaneous maxacalcitol injection therapy on enlarged parathyroid glands in chronic dialysis patients
    Hiroyasu Yamamoto
    Department of Internal Medicine, Jikei University School of Medicine, Tokyo, Japan
    Nephrol Dial Transplant 18:iii50-2. 2003
    ..Direct vitamin D analogue injection should not be performed as a primary treatment option because the adverse side effects are not overcome by this technique...
  19. ncbi request reprint [Dialysis as bridge therapy for renal transplantation: single center experience, a comparison of hemodialysis and continuous ambulatory peritoneal dialysis]
    Jun Mitome
    Division of Nephrology and Hypertension, Department of Internal Medicine, Jikei University School of Medicine, Tokyo, Japan
    Nihon Jinzo Gakkai Shi 47:813-20. 2005
    ..Therefore, we evaluated the influence of dialytic modality on the rate of kidney transplantation and outcome in our single center...
  20. ncbi request reprint Quantitative assessment of the peritoneal vessel density and vasculopathy in CAPD patients
    Ali M Sherif
    Department of Kidney and Hypertension, The Jikei University School of Medicine, 3 19 18 Nishi shinbashi, Tokyo 105 8471, Japan
    Nephrol Dial Transplant 21:1675-81. 2006
    ..We present a quantitative analysis of peritoneal vascular density as well as vasculopathy grades in relation to PD duration...
  21. doi request reprint Comparison between the pathology of encapsulating sclerosis and simple sclerosis of the peritoneal membrane in chronic peritoneal dialysis
    Ali M Sherif
    Department of Kidney and Hypertension, The Jikei University School of Medicine, Tokyo, Japan
    Ther Apher Dial 12:33-41. 2008
    ..Angiogenesis, vasculopathy, new membrane formation, fibrosis and degenerative changes of the compact zone are not unique characteristics for EPS. Larger size studies are recommended to verify this issue...
  22. doi request reprint Do serum hepcidin-25 levels correlate with oxidative stress in patients with chronic kidney disease not receiving dialysis?
    Yukio Maruyama
    Division of Kidney and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan
    Clin Nephrol 78:281-6. 2012
    ..Oxidative stress (OS) is also associated with iron metabolism. However, the clinical utility of hepcidin, especially its association with OS, in CKD patients not receiving dialysis is still unclear...
  23. doi request reprint A case of BK virus nephropathy and cytomegalovirus infection concurrent with plasma cell-rich acute rejection
    Aki Mafune
    Division of Kidney and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan
    Clin Transplant 26:49-53. 2012
    ..However, in this report, we describe the successful management of BKN and cytomegalovirus infection concurrent with plasma cell-rich acute rejection...
  24. ncbi request reprint Activities of enzymes in the malate-aspartate shuttle in the peripheral leukocytes of dogs and cats
    T Washizu
    Department of Veterinary Science, Nippon Veterinary and Animal Science University, Musashino, Tokyo, Japan
    Vet Res Commun 25:623-9. 2001
    ..High activities of MDH in canine leukocytes were confirmed by RT-PCR analysis on the total RNA extracted from leukocytes. It was concluded that there were significant differences between dogs and cats in the NADH shuttle system...
  25. doi request reprint Clinical and pathological features of donor/recipient body weight mismatch after kidney transplantation
    Takafumi Yamakawa
    Division of Nephrology and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan
    Nephrology (Carlton) 20:36-9. 2015
    ..Previous studies have shown that a donor/recipient body weight mismatch affects long-term graft survival and graft function after kidney transplantation. However, the mechanisms are not fully understood...
  26. ncbi request reprint [Effect of angiotensin II receptor antagonist (losartan) on renal function, serum potassium and blood pressure in patients with advanced renal failure: differences between patients with a serum creatinine (SCr) level higher than 3 mg/dl and those with a l
    Masaaki Nakayama
    Department of Kidney and Hypertension, Jikei University School of Medicine, Tokyo, Japan
    Nihon Jinzo Gakkai Shi 44:530-6. 2002
    ..0 mg/dl and those with a lower level. The results also support the notion that patients with advanced renal dysfunction are not precluded from AIIA administration...
  27. ncbi request reprint IRMA (whole PTH) is a more useful assay for the effect of PTH on bone than the Allegro intact PTH assay in CAPD patients with low bone turnover marker
    Yudo Tanno
    The Division of Kidney and Hypertension, Jikei University School of Medicine, Tokyo, Japan
    Nephrol Dial Transplant 18:iii97-8. 2003
    ..The w-PTH assay may be useful for more precise evaluation of PTH activity in end-stage renal disease patients...
  28. ncbi request reprint [Risk factors for death in patients starting PD for their first renal replacement therapy]
    Nanae Matsuo
    Division of Kidney and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan
    Nihon Jinzo Gakkai Shi 51:38-43. 2009
    ..Hence, a strict follow-up is needed in these patients...
  29. doi request reprint Low-grade endotoxemia contributes to chronic inflammation in hemodialysis patients: examination with a novel lipopolysaccharide detection method
    Hiroyuki Terawaki
    Division of Kidney and Hypertension, and Department of Molecular Cell Biology, Institute of DNA Medicine, Jikei University School of Medicine, Tokyo, Japan
    Ther Apher Dial 14:477-82. 2010
    ..In conclusion, the present study revealed a significant relationship between LPS and CRP using the novel ESP method, and suggested that very low-grade endotoxemia is contributing to systemic inflammation in HD patients...
  30. doi request reprint Risk factors for encapsulating peritoneal sclerosis: analysis of a 36-year experience in a University Hospital
    Masatsugu Nakao
    Division of Nephrology and Hypertension, Department of Internal Medicine, Jikei University School of Medicine, Tokyo, Japan
    Nephrology (Carlton) . 2016
    ..Encapsulating peritoneal sclerosis (EPS) is a rare but serious complication that occurs in peritoneal dialysis (PD) therapy. The present study aimed to identify the risk factors, especially peritonitis and biocompatible PD fluid...
  31. ncbi request reprint Possible prevention of uremic nausea by vitamin D receptor activators in non-dialysis patients with stage 5 chronic kidney disease
    Masato Ikeda
    Division of Nephrology and Hypertension, The Jikei University School of Medicine Katsushika Medical Center, 6 41 2 Katsushika ku, Tokyo, 125 8506, Japan
    Clin Exp Nephrol . 2016
    ..The objective of this study was to explore whether VDRA administration during the predialysis period is associated with a reduced prevalence of uremic nausea just prior to beginning dialysis...
  32. ncbi request reprint Is encapsulating peritoneal sclerosis a threatening issue in continuous ambulatory peritoneal dialysis? The Japanese experience
    Masaaki Nakayama
    Department of Kidney and Hypertension, and Department of Surgery, Tokyo Jikei University School of Medicine, Tokyo, Japan
    Perit Dial Int 23:S132-3. 2003
    ..Additional therapeutic and new preventive measures have to be established for EPS...
  33. doi request reprint Plasma adiponectin: a predictor of coronary heart disease in hemodialysis patients--a Japanese prospective eight-year study
    Fumi Takemoto
    Kidney Center, Toranomon Hospital, Teikyo University School of Medicine, Tokyo, Japan
    Nephron Clin Pract 111:c12-20. 2009
    ..Plasma adiponectin may play a protective role in the pathogenesis of cardiovascular disease in hemodialysis (HD) patients. We examined the effect of plasma adiponectin levels on the prognosis of the HD patients...
  34. doi request reprint Clinical issues regarding cinacalcet hydrochloride in Japan
    Keitaro Yokoyama
    Division of Nephrology and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, 3 25 8 Nishi shinbashi, Minato ku, Tokyo 105 8471, Japan
    Ther Apher Dial 13:S12-4. 2009
    ..Considering that the drug price of cinacalcet is lower in Japan than in the USA and Europe, it is highly likely that cinacalcet will be used to suppress PTH in Japan...
  35. ncbi request reprint Serum soluble α-klotho in hemodialysis patients
    Keitaro Yokoyama
    Division of Kidney and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan
    Clin Nephrol 77:347-51. 2012
    ..The extracellular domain of klotho is cleaved and released into various extracellular fluids, such as blood, urine, and cerebrospinal fluid, as soluble α-klotho (sαKl)...
  36. doi request reprint Morning hypertension determined by self-measurement at home predicts left ventricular hypertrophy in patients undergoing continuous ambulatory peritoneal dialysis
    Hiroyuki Terawaki
    Division of Kidney and Hypertension, The Jikei University School of Medicine, Tokyo, Japan
    Ther Apher Dial 16:260-6. 2012
    ..In conclusion, morning hypertension determined with self-measured BP was positively correlated with LVH, therefore self BP monitoring could be a useful method to predict LVH in CAPD patients...
  37. doi request reprint [Kidney and bone update : the 5-year history and future of CKD-MBD. About the guideline of the Japanese Society for Dialysis Therapy]
    Keitaro Yokoyama
    Division of Nephrology and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, Japan
    Clin Calcium 22:979-86. 2012
    ....
  38. doi request reprint Risk factors for encapsulating peritoneal sclerosis in long-term peritoneal dialysis: a retrospective observational study
    Masatsugu Nakao
    Department of Internal Medicine, Division of Kidney and Hypertension, The Jikei University School of Medicine, Tokyo, Japan
    Ther Apher Dial 18:68-73. 2014
    ..In patients on long-term PD therapy, D/P Cr and the duration of peritonitis are independently associated with EPS. Earlier treatment to promote an early recovery from PD-associated peritonitis could be critical in preventing EPS...
  39. doi request reprint Successful treatment of BK virus nephropathy using therapeutic drug monitoring of mycophenolic acid
    Akimitsu Kobayashi
    Division of Kidney and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan
    Nephrology (Carlton) 19:37-41. 2014
    ..This case report demonstrates the usefulness of MPA AUC0-12 for more accurate adjustment of immunosuppressive therapy and the difficulty of pathological differentiation of BKVN and acute cellular rejection. ..
  40. pmc Increased lymphatic vessels in patients with encapsulating peritoneal sclerosis
    Tatsuhiro Yaginuma
    Division of Kidney and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan
    Perit Dial Int 32:617-27. 2012
    ..In addition, because of technical limitations, morphology studies reported to date have examined only the parietal peritoneum. The morphologies of parietal and visceral lymphatic vessels in patients with EPS both need to be analyzed...
  41. doi request reprint Long-term safety and efficacy of a novel iron-containing phosphate binder, JTT-751, in patients receiving hemodialysis
    Keitaro Yokoyama
    Division of Nephrology and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan Electronic address
    J Ren Nutr 24:261-7. 2014
    ..JTT-751 is a novel phosphate binder containing ferric citrate as the active ingredient. This study investigated long-term safety and efficacy of JTT-751 for hyperphosphatemia in patients receiving hemodialysis...
  42. doi request reprint Acute vascular rejection during antituberculosis therapy in a kidney transplant patient
    Yasuyuki Nakada
    Division of Nephrology and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan
    Nephrology (Carlton) 19:27-30. 2014
    ..7 mg/dL on April 1 2013). The present case report demonstrates the difficulties associated with management of TAC-based regimens in kidney transplant patients undergoing antituberculosis therapy. We also review the relevant literature. ..
  43. ncbi request reprint Changes in activities of enzymes related to malate-aspartate shuttle in leukocytes from dogs given a herb supplement
    T Arai
    Division of Veterinary Biochemistry, Nippon Veterinary and Animal Science University, Tokyo, Japan
    J Vet Med Sci 63:695-7. 2001
    ..It is suggested that Echevaria glauca herb supplementation might activate NADH shuttle systems and mitochondrial energy metabolism in dogs...
  44. ncbi request reprint Recurrence and graft loss after renal transplantation in adults with IgA vasculitis
    Mayuko Kawabe
    Division of Nephrology and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, 3 25 8, Nishi Shimbashi, Minato ku, 105 8461, Tokyo, Japan
    Clin Exp Nephrol . 2016
    ..5-60 %, leading to graft loss in 0-50 % of these patients. However, limited data are available on recurrence and graft loss after renal transplantation...
  45. ncbi request reprint Gene expression of vitamin D hydroxylase and megalin in the remnant kidney of nephrectomized rats
    Fumi Takemoto
    Kidney Center, Toranomon Hospital, Tokyo, Japan
    Kidney Int 64:414-20. 2003
    ....
  46. doi request reprint [Management of hyperphosphatemia ; phosphate-binder]
    Keitaro Yokoyama
    The Jikei University School of Medicine, Department of Internal Medicine, Division of Nephrology and Hypertension
    Clin Calcium 19:205-12. 2009
    ..It may also attenuate coronary and aortic calcification and has a number of other beneficial effects on lipid metabolism and inflammation among others...
  47. doi request reprint Nafamostat mesilate as an anticoagulant during continuous veno-venous hemodialysis: a three-year retrospective cohort study
    Yukio Maruyama
    Division of Kidney and Hypertension, The Jikei University School of Medicine, Tokyo, Japan
    Int J Artif Organs 34:571-6. 2011
    ..The aim of this study was to evaluate the efficacy (filter survival) and safety (bleeding complications) of nafamostat mesilate in CRRT for acute kidney injury (AKI) among critically ill patients...
  48. pmc Interactions between serum vitamin D levels and vitamin D receptor gene FokI polymorphisms for renal function in patients with type 2 diabetes
    Keitaro Yokoyama
    Division of Kidney, Hypertension, Department of Internal Medicine, Jikei University School of Medicine, Tokyo, Japan
    PLoS ONE 7:e51171. 2012
    ....
  49. doi request reprint A randomized trial of JTT-751 versus sevelamer hydrochloride in patients on hemodialysis
    Keitaro Yokoyama
    Division of Kidney and Hypertension, Department of Internal Medicine, Jikei University School of Medicine, Tokyo, Japan
    Nephrol Dial Transplant 29:1053-60. 2014
    ..JTT-751 is a novel phosphate binder containing ferric citrate as the active ingredient...
  50. pmc Ferric citrate hydrate for the treatment of hyperphosphatemia in nondialysis-dependent CKD
    Keitaro Yokoyama
    Division of Kidney and Hypertension, Department of Internal Medicine, Jikei University School of Medicine, Tokyo, Japan, Japanese Red Cross, Fukuoka Hospital, Fukuoka, Japan, Department of Blood Purification, Kidney Center, Tokyo Women s Medical University, Tokyo, Japan, Division of Nephrology, Endocrinology and Metabolism, Tokai University School of Medicine, Isehara, Japan, Department of Nephrology, Hypertension, Diabetology, Endocrinology, and Metabolism, Fukushima Medical University School of Medicine, Fukushima, Japan, Department of Hematology, Nephrology and Rheumatology, Akita University, Akita, Japan, Kitasato University East Hospital Clinical Trial Center, Sagamihara, Japan, Denver Nephrologists, PC, Denver, Colorado
    Clin J Am Soc Nephrol 9:543-52. 2014
    ..Ferric citrate hydrate is a novel iron-based phosphate binder being developed for hyperphosphatemia in patients with CKD...
  51. doi request reprint Monitoring of body water composition by the simultaneous use of bioelectrical impedance analysis and Crit-Line(®) during hemodialysis
    Naoki Sugano
    Division of Kidney and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, 3 25 8 Nishi shinbashi, Minato ku, Tokyo, 105 8461, Japan
    Clin Exp Nephrol 18:944-51. 2014
    ..Crit-Line(®) (CL), on the other hand, assesses intravascular water (IVW) volume. We evaluate continuous changes in body water composition during hemodialysis (HD) with concurrent use of BIA and CL...
  52. doi request reprint Plasma cell-rich rejection accompanied by acute antibody-mediated rejection in a patient with ABO-incompatible kidney transplantation
    Maiko Furuya
    Division of Nephrology and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan
    Nephrology (Carlton) 19:31-4. 2014
    ..We also include a review of the related literature. ..
  53. doi request reprint Assessing the immune state of dogs suffering from pituitary gland dependent hyperadrenocorticism by determining changes in peripheral lymphocyte subsets
    A Mori
    Department of Veterinary Science, Nippon Veterinary and Life Science University, 1 7 1 Kyonancho, Musashino, Tokyo, 180 8602, Japan
    Vet Res Commun 33:757-69. 2009
    ..PDH dogs may be suffering from an immuno-depressed state as evidenced by significant differences in lymphocyte subset populations. Furthermore, treatment of both PDH and concurrent disease might improve lymphocyte subset distribution...
  54. pmc Associations among serum trimethylamine-N-oxide (TMAO) levels, kidney function and infarcted coronary artery number in patients undergoing cardiovascular surgery: a cross-sectional study
    Aki Mafune
    Division of Molecular Epidemiology, Jikei University School of Medicine, Tokyo, Japan
    Clin Exp Nephrol 20:731-739. 2016
    ..We aimed to clarify whether TMAO levels are associated with the number of infarcted coronary arteries as a measure of the severity of atherosclerosis, with adjustment using a priori-defined covariates such as kidney function...
  55. doi request reprint Change in glomerular volume and its clinicopathological impact after kidney transplantation
    Akimitsu Kobayashi
    Division of Nephrology and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan
    Nephrology (Carlton) 20:31-5. 2015
    ..Although the glomerular volume in baseline biopsies predicts late allograft function, the relationship between allograft function and the annual changes in glomerular volume after kidney transplantation are unclear...
  56. pmc The Different Association between Serum Ferritin and Mortality in Hemodialysis and Peritoneal Dialysis Patients Using Japanese Nationwide Dialysis Registry
    Yukio Maruyama
    Division of Nephrology and Hypertension, Jikei University School of Medicine, Tokyo, Japan
    PLoS ONE 10:e0143430. 2015
    ..However, associations between serum ferritin and mortality are unclear and there have been no investigations among patients undergoing peritoneal dialysis (PD)...
  57. pmc Proton Pump Inhibitor Use and Magnesium Concentrations in Hemodialysis Patients: A Cross-Sectional Study
    Akio Nakashima
    Division of Nephrology and Hypertension, Department of Internal Medicine, Jikei University School of Medicine, Tokyo, Japan
    PLoS ONE 10:e0143656. 2015
    ..05; 95% CI: 1.14-3.69; P = 0.017). PPI use is associated with an increased risk of hypomagnesemia in hemodialysis patients. Future prospective studies are needed to explore magnesium replacement in PPI users on hemodialysis. ..
  58. ncbi request reprint Phosphate overload accelerates vascular calcium deposition in end-stage renal disease patients
    Takashi Shigematsu
    Division of Nephrology and Hypertension, Jikei University School of Medicine, Japan
    Nephrol Dial Transplant 18:iii86-9. 2003
    ..These results suggest that the control of phosphate excess is important for prevention of calcium deposition on arteriole walls in ESRD patients...
  59. doi request reprint [Chronic kidney disease (CKD) and bone. Vascular calcification in CKD]
    Keitaro Yokoyama
    Division of Nephrology and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine
    Clin Calcium 19:552-8. 2009
    ..Calcium and phosphate load are an important driver of vascular calcification...
  60. doi request reprint L-type voltage-dependent calcium channel alpha subunit 1C is a novel candidate gene associated with secondary hyperparathyroidism: an application of haplotype-based analysis for multiple linked single nucleotide polymorphisms
    Keitaro Yokoyama
    Division of Kidney and Hypertension, Department of Internal Medicine, Jikei University School of Medicine, Tokyo, Japan keitaro jikei ac jp
    Nephron Clin Pract 115:c237-43. 2010
    ..Since CACNA1C is a relatively large molecule, we examined 84 SNP markers from the CACNA1C region located on chromosome 12 by haplotype case-control association analysis...
  61. doi request reprint Nonenzymatic cross-linking pentosidine increase in bone collagen and are associated with disorders of bone mineralization in dialysis patients
    Jun Mitome
    Division of Kidney and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, Minato ku, Tokyo, Japan
    Calcif Tissue Int 88:521-9. 2011
    ..This study suggests that AGE collagen cross-links strongly associate with disorders of bone metabolism in dialysis patients...
  62. doi request reprint [CKD-MBD (Chronic Kidney Disease-Mineral and Bone Disorder). Paradigm shift in CKD-MBD guideline]
    Keitaro Yokoyama
    Division of Nephrology and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine
    Clin Calcium 20:1012-20. 2010
    ..Then, new therapeutic modalities including cinacalcet and lanthanum carbonate have recently been introduced into the Japanese market, after JSDT guideline was published. Now, the revised version of the guideline has been prepared...
  63. ncbi request reprint [Klotho and phosphate metabolism]
    Keitaro Yokoyama
    Division of Nephrology and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, Japan
    Clin Calcium 22:1531-6. 2012
    ..The Klotho protein not only serves as a coreceptor for FGF23, but also functions as a humoral factor...
  64. pmc Dialysate temperature adjustment as an effective treatment for baroreflex failure syndrome in hemodialysis patient
    Natsumi Tanabe
    Jikei University Hospital, 3 25 8, Nishishimbashi, Minato ku, Tokyo 105 0003, Japan
    BMC Nephrol 15:151. 2014
    ..We experienced a case of hemodialysis patient who had difficulty in controlling blood pressure during dialysis because of his baroreflex failure syndrome and successfully controlled his blood pressure by adjusting dialysate temperature...
  65. doi request reprint JTT-751 for treatment of patients with hyperphosphatemia on peritoneal dialysis
    Keitaro Yokoyama
    Division of Nephrology and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan
    Nephron Clin Pract 128:135-40. 2014
    ..JTT-751 (ferric citrate hydrate) is a novel iron-based phosphate approved in Japan for the treatment of hyperphosphatemia in dialysis and nondialysis patients with chronic kidney disease...
  66. doi request reprint Combined therapy with peritoneal dialysis and hemodialysis: a multicenter retrospective observational cohort study in Japan
    Yukio Maruyama
    Division of Nephrology and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan
    Blood Purif 38:149-53. 2014
    ..Combining peritoneal dialysis (PD) and hemodialysis (HD) has been common treatment option in Japan...
  67. doi request reprint [Basic and clinical aspects of calcimimetics. Calcimimetics and vascular calcification]
    Keitaro Yokoyama
    The Jikei University School of Medicine, Department of Internal Medicine, Division of Nephrology and Hypertension, Japan
    Clin Calcium 18:95-102. 2008
    ..To clarify it, EVOLVE examination is going now...
  68. ncbi request reprint Intraoperative 99mTc-MIBI-guided detection of ectopic glands in secondary hyperparathyroidism
    Hiroshi Takeyama
    Department of Surgery, The Jikei University School of Medicine, Nishi sinbashi, Tokyo, Japan
    Int Surg 94:154-63. 2009
    ..Using intraoperative 99mTc-MIBI-guided surgery in cases of 2-HPT will ensure all ectopic parathyroid glands are detected, making the surgery easier to perform and the outcome more successful...
  69. doi request reprint A higher serum alkaline phosphatase is associated with the incidence of hip fracture and mortality among patients receiving hemodialysis in Japan
    Yukio Maruyama
    Division of Nephrology and Hypertension, The Jikei University School of Medicine, Tokyo, Japan
    Nephrol Dial Transplant 29:1532-8. 2014
    ..However, unlike calcium, phosphate or parathyroid hormone, the relationship between serum ALP and patient outcome receiving hemodialysis (HD) in Japan is unknown...
  70. ncbi request reprint Activities of enzymes related to the malate-aspartate shuttle in the blood cells of thoroughbred horses undergoing training exercise
    T Arai
    Division of Veterinary Biochemistry, Nippon Veterinary and Animal Science University, Musashino, Tokyo, Japan
    Vet Res Commun 25:577-83. 2001
    ..This increase in the MDH activity in their WBC is considered to reflect the increased metabolic activity in the race horses resulting from the training...
  71. ncbi request reprint Cytosolic ratio of malate dehyrogenase/lactate dehydrogenase activity in peripheral leukocytes of race horses with training
    T Arai
    Department of Veterinary Science, Nippon Veterinary and Animal Science University, Kyonancho, Musashino, Tokyo 180 8602, Japan
    Res Vet Sci 72:241-4. 2002
    ..Increase in the M/L ratio was considered to reflect elevation of energy metabolism in animal tissues. The M/L ratio may be a useful parameter to evaluate the difference in metabolic states between race horses and riding horses...
  72. ncbi request reprint The activity ratio of the cytosolic MDH/LDH and the isoenzyme pattern of LDH in the peripheral leukocytes of dogs, cats and rabbits
    T Washizu
    Department of Veterinary Science, Nippon Veterinary and Animal Science University, Musashino, Tokyo, Japan
    Vet Res Commun 26:341-6. 2002
    ..LDH-1 and LDH-2 were dominant in rabbit leukocytes, whereas LDH-5 was dominant in feline leukocytes. It was evident that there were significant differences in energy metabolism between the leukocytes of dogs, rabbits and cats...
  73. ncbi request reprint Comparison of plasma metabolite concentrations and lactate dehydrogenase activity in dogs, cats, horses, cattle and sheep
    T Sako
    Department of Veterinary Science, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan
    Vet Res Commun 31:413-7. 2007
  74. ncbi request reprint Problems in adapting the K/DOQI guidelines for Japanese patients with end stage renal failure
    Keitaro Yokoyama
    The Division of Nephrology and Hypertension, Jikei University School of Medicine, 3 25 8 Nishi shinbashi, Minato ku, Tokyo 105 8471, Japan
    Ther Apher Dial 9:9-10. 2005
    ..In addition, differences in the dose and type of the calcium-containing phosphorus adsorbent and active vitamin D used should also be taken into consideration...
  75. ncbi request reprint [Mechanism, imaging technique and therapy for vascular calcification in patients of chronic kidney disease]
    Hiraku Yoshida
    The Jikei University School of Medicine, Department of Internal Medicine, Division of Nephrology and Hypertension, Japan
    Clin Calcium 17:726-33. 2007
    ..Through greater understanding of both the mechanism and clinical consequence of vascular calcification, future therapeutic strategies may be more effectively designed and applied...
  76. doi request reprint Effect of aliskiren in chronic kidney disease patients with refractory hypertension undergoing hemodialysis: a randomized controlled multicenter study
    Satoru Kuriyama
    Division of Kidney and Hypertension, Department of Internal Medicine, Jikei University School of Medicine, 3 25 8 Nishi shinbashi, Minato ku, Tokyo, 105 8461, Japan
    Clin Exp Nephrol 18:821-30. 2014
    ..The purpose of this study was to evaluate the effect of the DRI, aliskiren, in patients with therapy-resistant hypertension undergoing hemodialysis (HD)...
  77. ncbi request reprint Insertion/deletion polymorphism in the angiotensin-converting enzyme gene affects heart weight
    K Nakahara
    Department of Laboratory Medicine, Tokyo Metropolitan Geriatric Hospital, Tokyo, Japan
    Circulation 101:148-51. 2000
    ..The ACE polymorphism should result in varied Ang II concentrations and hence affect left ventricular mass. We therefore investigated whether ACE genotype is a predictor of heart weight...
  78. ncbi request reprint High iron storage levels are associated with increased DNA oxidative injury in patients on regular hemodialysis
    Kazunobu Yoshimura
    Department of Kidney and Hypertension, Tokyo Jikei University School of Medicine, 3 25 8 Nishishinbashi, Minato ku, Tokyo 105 8461, Japan
    Clin Exp Nephrol 9:158-63. 2005
    ..Here, we report our investigation of the relation between iron storage and DNA oxidative injury in HD patients...
  79. ncbi request reprint Autoantibodies against carbonic anhydrase II are increased in renal tubular acidosis associated with Sjogren syndrome
    Fumi Takemoto
    Kidney Center, Toranomon Hospital, Tokyo, Japan
    Am J Med 118:181-4. 2005
  80. doi request reprint Removal of 2-arachidonylglycerol by direct hemoperfusion therapy with polymyxin B immobilized fibers benefits patients with septic shock
    Yoichi Kase
    Department of Anesthesiology and Intensive Care Medicine, Jikei University School of Medicine, Tokyo, Japan
    Ther Apher Dial 12:374-80. 2008
    ..The removal of 2-AG by PMX-DHP benefits patients with septic shock by stabilizing cardiovascular status and decreasing long-term oxidative stress...
  81. ncbi request reprint Particle size analysis of high density lipoproteins in patients with genetic cholesteryl ester transfer protein deficiency
    T Arai
    Department of Clinical Chemistry, Toranomon Hospital, 2 2 2 Toranomon, Minato ku, Tokyo 105 8470, Japan
    Clin Chim Acta 301:103-17. 2000
    ..01). These results indicate that extra-large HDL may be an index to clarify the relationship between genetic CETP deficiency and atherosclerosis...
  82. doi request reprint Non-targeted analyses of animal plasma: betaine and choline represent the nutritional and metabolic status
    K Katayama
    School of Veterinary Medicine, Faculty of Veterinary Science, Nippon Veterinary and Life Science University, 1 7 1 Kyonan cho, Musashino shi, Tokyo, Japan
    J Anim Physiol Anim Nutr (Berl) 97:119-25. 2013
    ..The metabolite was identified as betaine by LC-MS/MS. This result indicates that betaine and its metabolic precursor, choline, may be useful biomarkers to evaluate the nutritional and metabolic status of animals...
  83. ncbi request reprint Increased serum and urinary neopterin in nephrotic syndrome indicate cell-mediated immune dysfunction
    K Oda
    Department of Internal Medicine, Teikyo University School of Medicine, 11 1, Kaga, 2 chome, Itabashi ku, Tokyo, 173 8605, Japan
    Am J Kidney Dis 34:611-7. 1999
    ..Increased serum NP concentrations and urinary NP/Cr ratios may reflect disordered cell-mediated immunity in the nephrotic syndrome, irrespective of glomerular histology or interstitial cell infiltration...
  84. ncbi request reprint Correlation of telomere lengths in normal and cancers tissue in the large bowel
    K Nakamura
    Department of Clinical Pathology, Tokyo Metropolitan Institute of Gerontology, 32 5, Sakaecho Itabashi ku, 173 0015, Tokyo, Japan
    Cancer Lett 158:179-84. 2000
    ..Straight, essentially parallel, lines were obtained for the two cases, normal tissue values being about 2 kilobase pairs (kbp) higher, with a significant correlation between data at the individual patient level...
  85. doi request reprint Comparison of three commercially available prescription diet regimens on short-term post-prandial serum glucose and insulin concentrations in healthy cats
    A Mori
    Department of Veterinary Science, School of Veterinary Medicine, Nippon Veterinary and Life Science University, 1 7 1 Kyonancho, Musashino, Tokyo, 180 8602, Japan
    Vet Res Commun 33:669-80. 2009
    ..As such, having a better understanding for each dietary component, may lead us to better understand how we can synergize certain dietary components to aid in DM management...
  86. doi request reprint Comparison of insulin signaling gene expression in insulin sensitive tissues between cats and dogs
    A Mori
    Department of Veterinary Science, Nippon Veterinary and Life Science University, 1 7 1 Kyonancho, Musashino, Tokyo, 180 8602, Japan
    Vet Res Commun 33:211-26. 2009
    ..Therefore, a combination of genetic and environmental factors appears to make felines more prone to suffer from insulin resistance and type 2 DM than canines...
  87. doi request reprint Clinical significance of plasma mannose concentrations in healthy and diabetic dogs
    A Mori
    Department of Veterinary Science, Nippon Veterinary and Life Science University, Musashino, Tokyo, 180 8602, Japan
    Vet Res Commun 33:439-51. 2009
    ..Therefore, plasma mannose levels obtained via glucose tolerance testing may be used as a new diagnostic method for evaluating insulin resistance or deficiency in diabetic dogs...
  88. doi request reprint Plasma glucose, mannose, and non-esterified fatty acid concentrations in layer-type chickens
    T Sato
    Faculty of Veterinary Science, School of Veterinary Medicine, Nippon Veterinary and Life Science University, Musashino, Tokyo, Japan
    Br Poult Sci 49:731-5. 2008
    ..3. At the age of 18 and 150 d, plasma glucose concentrations were elevated and plasma mannose and NEFA concentrations were decreased after regular feeding, compared to fasting levels...
  89. ncbi request reprint Changes in activities of enzymes related to energy metabolism in testicular tissues of dogs with seminoma
    T Arai
    Department of Veterinary Science, Nippon Veterinary and Animal Science University, Musashino, Tokyo, Japan
    Vet Res Commun 26:347-52. 2002
    ..These enzymatic activities may be useful indicators with which to evaluate changes in the metabolic conditions in testicular tissues of dogs with seminoma...
  90. ncbi request reprint Early squamous cell carcinoma of the oesophagus: the Japanese viewpoint
    K Takubo
    Research Team for Geriatric Diseases, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan
    Histopathology 51:733-42. 2007
    ..As a result of advances in the development of endoscopes, pathologists are now expected to diagnose very minute lesions, < 1 mm in size, in the oesophagus...
  91. doi request reprint Fulminant type 1 diabetes mellitus observed in insulin receptor substrate 2 deficient mice
    T Arai
    Department of Veterinary Science, School of Veterinary Medicine, Nippon Veterinary and Life Science University, Musashino, Tokyo, 180 8602, Japan
    Clin Exp Med 8:93-9. 2008
    ..IRS2-deficient mice may be a useful animal model for studying the degradation mechanism of pancreatic beta cells in the process of development of fulminant type 1 DM...
  92. doi request reprint Decreased gene expression of insulin signaling genes in insulin sensitive tissues of obese cats
    A Mori
    Department of Veterinary Science, School of Veterinary Medicine, Nippon Veterinary and Life Science University, 1, 7, 1 Kyonancho, Musashino, Tokyo, Japan
    Vet Res Commun 33:315-29. 2009
    ..As such, the monitoring of key insulin signaling genes may have some important diagnostic value to determine the risk level and degree of obesity induced insulin resistance...
  93. doi request reprint Serum glycated albumin: Potential use as an index of glycemic control in diabetic dogs
    T Sako
    Department of Veterinary Nursing, Nippon Veterinary and Life Science University, Musashino, Tokyo, 180 8602, Japan
    Vet Res Commun 33:473-9. 2009
    ..Furthermore, serum GA% can reflect long-term changes (almost 1-3 weeks) in blood glucose concentration and the effect of injected insulin in diabetic dogs...
  94. ncbi request reprint Raised plasma concentrations of parathyroid hormone related peptide in hypercalcemic multiple myeloma
    T Horiuchi
    Section of Endocrinology, Tokyo Metropolitan Geriatric Hospital, Japan
    Horm Metab Res 29:469-71. 1997
    ..Therefore, further studies are necessary to elucidate the pathogenesis of hypercalcemia in multiple myeloma...
  95. ncbi request reprint Changes in activities of enzymes related to energy metabolism in peripheral leukocytes of diabetic dogs with glycemic control by intensive insulin treatment
    T Arai
    Division of Veterinary Biochemistry, Department of Veterinary Science, Nippon Veterinary and Animal Science University, Kyonancho, Musashino, Tokyo 180 8602, Japan
    Res Vet Sci 73:183-6. 2002
    ....
  96. ncbi request reprint Activities of enzymes in the malate-aspartate shuttle and the isoenzyme pattern of lactate dehydrogenase in plasma and peripheral leukocytes of lactating Holstein cows and riding horses
    T Arai
    Divisions of Veterinary Biochemistry, Department of Veterinary Science, Nippon Veterinary and Animal Science University, Kyonancho, Musashino, Tokyo 180 8602, Japan
    Res Vet Sci 75:15-9. 2003
    ..There were significant differences in activities of malate-aspartate shuttle enzymes, ML ratio and LDH isoenzyme patterns in the cytosolic fractions of leukocytes between the lactating cows and the riding horses...
  97. ncbi request reprint Enzyme activities in some types of peripheral leukocytes of thoroughbred race horses before and after the races
    M Hosoya
    Division of Veterinary Biochemistry, Department of Veterinary Science, Nippon Veterinary and Animal Science University, 1 7 1 Kyonancho, Musashino, Tokyo 180 8602, Japan
    Res Vet Sci 77:101-4. 2004
    ..The cytosolic ratio of MDH/LDH activity (ML ratio) in leukocytes decreased significantly after racing, and the ratio may be a useful indicator to evaluate energy metabolism in race horses...
  98. ncbi request reprint Malate dehydrogenase activities are lower in some types of peripheral leucocytes of dogs and cats with type 1 diabetes mellitus
    E Magori
    Division of Veterinary Biochemistry, Department of Veterinary Science, Nippon Veterinary and Animal Science University, 1 7 1 Kyonancho, Musashino, Tokyo 180 8602, Japan
    Res Vet Sci 78:39-44. 2005
    ..The smaller M / L ratio appeared to reflect depression of energy metabolism in the diabetic animals. Intrinsically lower and further decreased MDH activities may be factors that induce insulin resistance observed in diabetic cats...
  99. ncbi request reprint Changes in activities of enzymes related to energy metabolism in peripheral leukocytes of fattening steers
    N Kimura
    Division of Animal Nutrition, Department of Animal Science, Nippon Veterinary and Animal Science University, 1 7 1 Kyonancho, Musashino, Tokyo 180 8602, Japan
    Vet Res Commun 29:19-26. 2005
    ..The cytosolic ratio of MDH/lactate dehydrogenase (LDH) activity in leukocytes increased significantly in the fattening process and was considered to be a useful indicator for evaluating changes in energy metabolism in steers...
  100. ncbi request reprint Changes in peripheral leukocytes enzymes activity and plasma metabolite concentrations in growing Holstein calves
    T Arai
    Department of Veterinary Science, Nippon Veterinary and Animal Science University, 1 7 1 Kyonancho, Musashino, Tokyo 180 8602, Japan
    Res Vet Sci 81:19-23. 2006
    ..Some peripheral leukocyte enzymes such as LDH and HK may be good indicators to evaluate changes in energy metabolism of growing calves...
  101. ncbi request reprint Comparison of activities of enzymes related to energy metabolism in peripheral leukocytes and livers between Holstein dairy cows and ICR mice
    A Tanaka
    Department of Veterinary Science, Nippon Veterinary and Animal Science University, Musashino, Tokyo 180 8602, Japan
    Vet Res Commun 30:29-38. 2006
    ..The LDH isoenzyme patterns were very similar between leukocytes and liver in each animal species. Some enzymes in leukocytes may reflect those enzymes activities in liver and be a useful indicator for energy metabolism in animals...