Hiroshi Ohrui

Summary

Affiliation: Yokohama College of Pharmacy
Country: Japan

Publications

  1. doi request reprint A proposal of the structure of modified nucleosides expected to be highly anti-viral active and lowly toxic
    Hiroshi Ohrui
    Nucleic Acids Symp Ser (Oxf) . 2008
  2. pmc Development of modified nucleosides that have supremely high anti-HIV activity and low toxicity and prevent the emergence of resistant HIV mutants
    Hiroshi Ohrui
    Yokohama College of Pharmacy, Kanagawa, Japan
    Proc Jpn Acad Ser B Phys Biol Sci 87:53-65. 2011
  3. doi request reprint A proposed structure of modified nucleosides expected to have high antiviral activity and low toxicity
    Hiroshi Ohrui
    Yokohama College of Pharmacy, Totsuka, Yokohama, Japan
    Nucleosides Nucleotides Nucleic Acids 28:772-5. 2009
  4. ncbi request reprint Development of highly potent chiral discrimination methods that solve the problems of diastereomer method
    Hiroshi Ohrui
    Yokohama College of Pharmacy, 601 Matano cho, Totsuka, Yokohama 245 0066, Japan
    Anal Sci 24:31-8. 2008
  5. ncbi request reprint 2'-deoxy-4'-C-ethynyl-2-fluoroadenosine: a nucleoside reverse transcriptase inhibitor with highly potent activity against wide spectrum of HIV-1 strains, favorable toxic profiles, and stability in plasma
    Hiroshi Ohrui
    Yokomama College of Pharmacy, 601 Matano cho, Totsuka, Yokohama, Japan
    Nucleosides Nucleotides Nucleic Acids 26:1543-6. 2007
  6. ncbi request reprint 2'-deoxy-4'-C-ethynyl-2-fluoroadenosine, a nucleoside reverse transcriptase inhibitor, is highly potent against all human immunodeficiency viruses type 1 and has low toxicity
    Hiroshi Ohrui
    Yokohama College of Pharmacy, 601 Matanocho, Tozukaku, Yokohama 245 0066, Japan
    Chem Rec 6:133-43. 2006
  7. ncbi request reprint Structure of an unsaturated fatty acid with unique vicinal dimethyl branches isolated from the Okinawan soft coral of the genus Sinularia
    Kinzo Watanabe
    School of Life Sciences, Tokyo University of Pharmacy and Life Sciences, Hachioji, Tokyo, Japan
    Chem Pharm Bull (Tokyo) 56:861-3. 2008
  8. ncbi request reprint Chiral discrimination of primary amines by HPLC after labeling with a chiral derivatization reagent, trans-2-(2,3-anthracenedicarboximido)-cyclohexanecarbonyl chloride
    Kazuaki Akasaka
    Graduate School of Life Sciences, Tohoku University, Sendai, Japan
    J Sep Sci 29:1390-8. 2006
  9. ncbi request reprint Synthesis of the four stereoisomers of 2,6-dimethyloctane-1,8-dioic acid, a component of the copulation release pheromone of the cowpea weevil, Callosobruchus maculatus
    Tomonori Nakai
    Department of Fermentation Science, Faculty of Applied Biological Science, Tokyo University of Agriculture, Japan
    Biosci Biotechnol Biochem 69:2401-8. 2005
  10. ncbi request reprint Crystalline structure of N-(S)-2-heptyl (1R,2R)-2-(2,3-anthracenedicarboximido)cyclohexanecarboxamide that differs from its preferred conformation in the solvent used for crystallization
    Kazuaki Akasaka
    Graduate School of Life Sciences, Tohoku University, Aobaku, Sendai, Japan
    Biosci Biotechnol Biochem 69:2002-4. 2005

Collaborators

  • Hiroyuki Hayakawa
  • Arata Yajima
  • Kenji Mori
  • Kazuaki Akasaka
  • Satoru Kohgo
  • Kenji Kitano
  • Shinji Sakata
  • Kohei Yamada
  • Hiroaki Mitsuya
  • Masao Matsuoka
  • Daisuke Nameki
  • Eiichi Kodama
  • Kinzo Watanabe
  • Takashi Ohtaki
  • Tomonori Nakai
  • Noriyuki Ashida
  • Haruko Takahashi
  • Ryota Makino
  • Kazuo Iguchi
  • Tomoo Nukada
  • Miki Ohtaki
  • Takeshi Kitahara
  • Goro Yabuta
  • Takayuki Kaihoku
  • Chizuko Kabuto
  • Yuko Iwai
  • Seiya Shichijyukari
  • Hiroshi Meguro

Detail Information

Publications19

  1. doi request reprint A proposal of the structure of modified nucleosides expected to be highly anti-viral active and lowly toxic
    Hiroshi Ohrui
    Nucleic Acids Symp Ser (Oxf) . 2008
    ..The structure of modified nucleosides expected to be highly anti-viral active and lowly toxic is proposed...
  2. pmc Development of modified nucleosides that have supremely high anti-HIV activity and low toxicity and prevent the emergence of resistant HIV mutants
    Hiroshi Ohrui
    Yokohama College of Pharmacy, Kanagawa, Japan
    Proc Jpn Acad Ser B Phys Biol Sci 87:53-65. 2011
    ....
  3. doi request reprint A proposed structure of modified nucleosides expected to have high antiviral activity and low toxicity
    Hiroshi Ohrui
    Yokohama College of Pharmacy, Totsuka, Yokohama, Japan
    Nucleosides Nucleotides Nucleic Acids 28:772-5. 2009
    ..This article describes modified nucleosides with deactivated 3'-OH and modified at two or more positions. These are expected to have high antiviral activity as well as have low toxicity...
  4. ncbi request reprint Development of highly potent chiral discrimination methods that solve the problems of diastereomer method
    Hiroshi Ohrui
    Yokohama College of Pharmacy, 601 Matano cho, Totsuka, Yokohama 245 0066, Japan
    Anal Sci 24:31-8. 2008
    ....
  5. ncbi request reprint 2'-deoxy-4'-C-ethynyl-2-fluoroadenosine: a nucleoside reverse transcriptase inhibitor with highly potent activity against wide spectrum of HIV-1 strains, favorable toxic profiles, and stability in plasma
    Hiroshi Ohrui
    Yokomama College of Pharmacy, 601 Matano cho, Totsuka, Yokohama, Japan
    Nucleosides Nucleotides Nucleic Acids 26:1543-6. 2007
    ..The nucleoside will prevent or delay the emergence of drug-resistant HIV-1 variants and be an ideal therapeutic agent for both HIV-1 and HBV infections...
  6. ncbi request reprint 2'-deoxy-4'-C-ethynyl-2-fluoroadenosine, a nucleoside reverse transcriptase inhibitor, is highly potent against all human immunodeficiency viruses type 1 and has low toxicity
    Hiroshi Ohrui
    Yokohama College of Pharmacy, 601 Matanocho, Tozukaku, Yokohama 245 0066, Japan
    Chem Rec 6:133-43. 2006
    ....
  7. ncbi request reprint Structure of an unsaturated fatty acid with unique vicinal dimethyl branches isolated from the Okinawan soft coral of the genus Sinularia
    Kinzo Watanabe
    School of Life Sciences, Tokyo University of Pharmacy and Life Sciences, Hachioji, Tokyo, Japan
    Chem Pharm Bull (Tokyo) 56:861-3. 2008
    ..The structure of the compound was determined based on the results of spectroscopic analysis and chemical conversion. The absolute configuration was deduced by applying the Ohrui-Akasaka method...
  8. ncbi request reprint Chiral discrimination of primary amines by HPLC after labeling with a chiral derivatization reagent, trans-2-(2,3-anthracenedicarboximido)-cyclohexanecarbonyl chloride
    Kazuaki Akasaka
    Graduate School of Life Sciences, Tohoku University, Sendai, Japan
    J Sep Sci 29:1390-8. 2006
    ....
  9. ncbi request reprint Synthesis of the four stereoisomers of 2,6-dimethyloctane-1,8-dioic acid, a component of the copulation release pheromone of the cowpea weevil, Callosobruchus maculatus
    Tomonori Nakai
    Department of Fermentation Science, Faculty of Applied Biological Science, Tokyo University of Agriculture, Japan
    Biosci Biotechnol Biochem 69:2401-8. 2005
    ..The stereoisomeric purities of the four synthetic isomers of 2 were determined by the HPLC analyses of their bis-2-(2,3-anthracenedicarboximide)-1-cyclohexyl esters...
  10. ncbi request reprint Crystalline structure of N-(S)-2-heptyl (1R,2R)-2-(2,3-anthracenedicarboximido)cyclohexanecarboxamide that differs from its preferred conformation in the solvent used for crystallization
    Kazuaki Akasaka
    Graduate School of Life Sciences, Tohoku University, Aobaku, Sendai, Japan
    Biosci Biotechnol Biochem 69:2002-4. 2005
    ....
  11. ncbi request reprint Potential of 4'-C-substituted nucleosides for the treatment of HIV-1
    Hiroyuki Hayakawa
    Biochemicals Division, Yamasa Corporation, Chiba, Japan
    Antivir Chem Chemother 15:169-87. 2004
    ..These results were recently reported by our collaborators. In this review, we summarize the design, synthesis and demonstrations of the anti-HIV activity of 4'-SNs, and then consider 4'-SNs as potential therapeutic agents for HIV-1...
  12. ncbi request reprint Chiral discrimination of branched-chain fatty acids by reversed-phase HPLC after labeling with a chiral fluorescent conversion reagent
    Kazuaki Akasaka
    Graduate School of Life Sciences, Tohoku University, Sendai, Japan
    Biosci Biotechnol Biochem 68:153-8. 2004
    ..A C30 column made it possible to separate diastereomeric esters up to C29 anteiso acid. It was possible to predict the absolute configuration of each acid by the elution order of the derivatives...
  13. ncbi request reprint Determination of the absolute configurations of the anteiso acid moieties of glycoglycerolipid S365A isolated from Corynebacterium aquaticum
    Kazuaki Akasaka
    Graduate School of Life Sciences, Tohoku University, Aobaku, Sendai, Japan
    Biosci Biotechnol Biochem 66:1719-22. 2002
    ..Both anteiso acids had the S configuration...
  14. ncbi request reprint Development of highly potent D-glucosamine-based chiral fluorescent labeling reagents and a microwave-assisted beta-selective glycosidation of a methyl glycoside reagent
    Hiroshi Ohrui
    Graduate School of Life Sciences, Tohoku University, Sendai
    Biosci Biotechnol Biochem 69:1054-7. 2005
    ..Those reagents showed very high chiral discrimination ability, and they made it possible to separate the eight stereoisomers of 4,8,12,16-tetramethylheptadecanol by HPLC after derivatizations...
  15. ncbi request reprint Synthesis of the four stereoisomers of 7-acetoxy-15-methylnonacosane, a component of the female sex pheromone of the screwworm fly, Cochliomyia hominivorax
    Kenji Mori
    Insect Pheromone and Traps Division, Fuji Flavor Co, Ltd, Midorigaoka 3 5 8, Hamura shi, Tokyo 205 8503, Japan
    Biosci Biotechnol Biochem 68:1768-78. 2004
    ..Three of the stereoisomers of 1 showed equivalent good pheromone activity, while the activity of (7R,15R)-1 was weak...
  16. ncbi request reprint Attempt to reduce cytotoxicity by synthesizing the L-enantiomer of 4'-C-ethynyl-2'-deoxypurine nucleosides as antiviral agents against HIV and HBV
    Kenji Kitano
    Biochemical Division, Yamasa Corporation, Choshi, Japan
    Antivir Chem Chemother 15:161-7. 2004
    ..The compounds' antiviral activity against HIV and HBV was then evaluated. Unfortunately, they demonstrated no activity and no cytotoxicity...
  17. ncbi request reprint Design, efficient synthesis, and anti-HIV activity of 4'-C-cyano- and 4'-C-ethynyl-2'-deoxy purine nucleosides
    Satoru Kohgo
    Biochemicals Division, Yamasa Corporation, Chiba, Japan
    Nucleosides Nucleotides Nucleic Acids 23:671-90. 2004
    ..Unfortunately, 4'-C-cyano derivatives showed lower activity against HIV-1, and two 4'-C-ethynyl derivatives suggested high toxicity in vivo...
  18. ncbi request reprint Synthesis of 4'-C-ethynyl and 4'-C-cyano purine nucleosides from natural nucleosides and their anti-HIV activity
    Satoru Kohgo
    Biochemicals Division, Yamasa Corporation, Choshi, Chiba, Japan
    Nucleosides Nucleotides Nucleic Acids 22:887-9. 2003
    ..These compounds exhibited very potent anti-HIV activity, and remained active against drug resistant HIV strains...