Shigeru Yatoh

Summary

Country: Japan

Publications

  1. ncbi request reprint Insulin sensitizers and atherosclerosis
    Shigeru Yatoh
    Division of Endocrinology and Metabolism, Department of Internal Medicine, Institute of Clinical Medicine, University of Tsukuba, Ibaraki, Japan
    J Atheroscler Thromb 9:276-9. 2002
  2. ncbi request reprint Antioxidants and an inhibitor of advanced glycation ameliorate death of retinal microvascular cells in diabetic retinopathy
    Shigeru Yatoh
    Division of Endocrinology and Metabolism, Department of Internal Medicine, Institute of Clinical Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan
    Diabetes Metab Res Rev 22:38-45. 2006
  3. doi request reprint Elovl6 promotes nonalcoholic steatohepatitis
    Takashi Matsuzaka
    Department of Endocrinology and Metabolism, University of Tsukuba, Tsukuba, Japan
    Hepatology 56:2199-208. 2012
  4. doi request reprint TFE3 controls lipid metabolism in adipose tissue of male mice by suppressing lipolysis and thermogenesis
    Yuri Fujimoto
    PhD, or Hitoshi Shimano, MD, PhD, Department of Internal Medicine Metabolism and Endocrinology, Faculty of Medicine, University of Tsukuba, 1 1 1, Tennodai, Tsukuba, Japan 305 8575 or
    Endocrinology 154:3577-88. 2013
  5. pmc Protein kinase Cbeta mediates hepatic induction of sterol-regulatory element binding protein-1c by insulin
    Takashi Yamamoto
    Department of Internal Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan
    J Lipid Res 51:1859-70. 2010
  6. doi request reprint Macrophage Elovl6 deficiency ameliorates foam cell formation and reduces atherosclerosis in low-density lipoprotein receptor-deficient mice
    Ryo Saito
    Department of Internal Medicine Endocrinology and Metabolism, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan
    Arterioscler Thromb Vasc Biol 31:1973-9. 2011
  7. doi request reprint TFE3 regulates muscle metabolic gene expression, increases glycogen stores, and enhances insulin sensitivity in mice
    Hitoshi Iwasaki
    Department of Internal Medicine, Faculty of Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Japan
    Am J Physiol Endocrinol Metab 302:E896-902. 2012
  8. doi request reprint Cholesterol accumulation and diabetes in pancreatic beta-cell-specific SREBP-2 transgenic mice: a new model for lipotoxicity
    Mayumi Ishikawa
    Department of Internal Medicine Endocrinology and Metabolism, Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1 1 1 Tennodai, Tsukuba City, Ibaraki, Japan, 305 8575
    J Lipid Res 49:2524-34. 2008
  9. doi request reprint TFE3 inhibits myoblast differentiation in C2C12 cells via down-regulating gene expression of myogenin
    Ayano Naka
    Doctoral Program of Sports Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1 1 1 Tennodai, Tsukuba, Ibaraki 305 8577, Japan
    Biochem Biophys Res Commun 430:664-9. 2013
  10. pmc Inhibition of ubiquitin ligase F-box and WD repeat domain-containing 7α (Fbw7α) causes hepatosteatosis through Krüppel-like factor 5 (KLF5)/peroxisome proliferator-activated receptor γ2 (PPARγ2) pathway but not SREBP-1c protein in mice
    Shin Kumadaki
    Department of Internal Medicine Endocrinology and Metabolism, Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1 1 1 Tennodai, Tsukuba, Ibaraki 305 8575, Japan
    J Biol Chem 286:40835-46. 2011

Collaborators

Detail Information

Publications34

  1. ncbi request reprint Insulin sensitizers and atherosclerosis
    Shigeru Yatoh
    Division of Endocrinology and Metabolism, Department of Internal Medicine, Institute of Clinical Medicine, University of Tsukuba, Ibaraki, Japan
    J Atheroscler Thromb 9:276-9. 2002
    ....
  2. ncbi request reprint Antioxidants and an inhibitor of advanced glycation ameliorate death of retinal microvascular cells in diabetic retinopathy
    Shigeru Yatoh
    Division of Endocrinology and Metabolism, Department of Internal Medicine, Institute of Clinical Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan
    Diabetes Metab Res Rev 22:38-45. 2006
    ..Therefore, we investigated apoptosis of RMCs in Goto-Kakizaki (GK) rats, a type 2 diabetic model, and involvement with antioxidants (a combination of vitamins C and E) or a novel inhibitor of advanced glycation, OPB-9195...
  3. doi request reprint Elovl6 promotes nonalcoholic steatohepatitis
    Takashi Matsuzaka
    Department of Endocrinology and Metabolism, University of Tsukuba, Tsukuba, Japan
    Hepatology 56:2199-208. 2012
    ....
  4. doi request reprint TFE3 controls lipid metabolism in adipose tissue of male mice by suppressing lipolysis and thermogenesis
    Yuri Fujimoto
    PhD, or Hitoshi Shimano, MD, PhD, Department of Internal Medicine Metabolism and Endocrinology, Faculty of Medicine, University of Tsukuba, 1 1 1, Tennodai, Tsukuba, Japan 305 8575 or
    Endocrinology 154:3577-88. 2013
    ..Our data provide new evidence that TFE3 regulates lipid metabolism by controlling the gene expression related to lipolysis and thermogenesis in adipose tissue. ..
  5. pmc Protein kinase Cbeta mediates hepatic induction of sterol-regulatory element binding protein-1c by insulin
    Takashi Yamamoto
    Department of Internal Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan
    J Lipid Res 51:1859-70. 2010
    ..This new understanding of PKCbeta involvement in nutritional regulation of SREBP-1c activation provides a new aspect of PKCbeta inhibition as a potential therapeutic target for diabetic complications...
  6. doi request reprint Macrophage Elovl6 deficiency ameliorates foam cell formation and reduces atherosclerosis in low-density lipoprotein receptor-deficient mice
    Ryo Saito
    Department of Internal Medicine Endocrinology and Metabolism, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan
    Arterioscler Thromb Vasc Biol 31:1973-9. 2011
    ..In this study, we investigated the roles of Elovl6 in foam cell formation in macrophages and atherosclerosis in mice...
  7. doi request reprint TFE3 regulates muscle metabolic gene expression, increases glycogen stores, and enhances insulin sensitivity in mice
    Hitoshi Iwasaki
    Department of Internal Medicine, Faculty of Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Japan
    Am J Physiol Endocrinol Metab 302:E896-902. 2012
    ..The potential role of TFE3 in regulating metabolic genes and glucose metabolism within skeletal muscle suggests that it may be used for treating metabolic diseases as well as increasing endurance in sport...
  8. doi request reprint Cholesterol accumulation and diabetes in pancreatic beta-cell-specific SREBP-2 transgenic mice: a new model for lipotoxicity
    Mayumi Ishikawa
    Department of Internal Medicine Endocrinology and Metabolism, Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1 1 1 Tennodai, Tsukuba City, Ibaraki, Japan, 305 8575
    J Lipid Res 49:2524-34. 2008
    ....
  9. doi request reprint TFE3 inhibits myoblast differentiation in C2C12 cells via down-regulating gene expression of myogenin
    Ayano Naka
    Doctoral Program of Sports Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1 1 1 Tennodai, Tsukuba, Ibaraki 305 8577, Japan
    Biochem Biophys Res Commun 430:664-9. 2013
    ..These findings indicated that TFE3 has a regulatory role in myoblast differentiation, and that transcriptional suppression of myogenin expression may be part of the mechanism of action...
  10. pmc Inhibition of ubiquitin ligase F-box and WD repeat domain-containing 7α (Fbw7α) causes hepatosteatosis through Krüppel-like factor 5 (KLF5)/peroxisome proliferator-activated receptor γ2 (PPARγ2) pathway but not SREBP-1c protein in mice
    Shin Kumadaki
    Department of Internal Medicine Endocrinology and Metabolism, Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1 1 1 Tennodai, Tsukuba, Ibaraki 305 8575, Japan
    J Biol Chem 286:40835-46. 2011
    ..Hepatic Fbw7α contributes to normal fatty acid and triglyceride metabolism, functions that represent novel aspects of this cell growth regulator...
  11. doi request reprint Nuclear SREBP-1a causes loss of pancreatic beta-cells and impaired insulin secretion
    Yuko Iwasaki
    Department of Internal Medicine Endocrinology and Metabolism, Graduate School of Comprehensive Human Sciences, 1 1 1 Tennodai, Tsukuba, Ibaraki 305 8575, Japan
    Biochem Biophys Res Commun 378:545-50. 2009
    ..The transgenic mice on a high fat/high sucrose diet still exhibited impaired insulin secretion and continuous beta-cell growth defect. Therefore, nuclear SREBP-1a, even at a low level, strongly disrupts beta-cell mass and function...
  12. pmc Circulating malondialdehyde-modified LDL-related variables and coronary artery stenosis in asymptomatic patients with type 2 diabetes
    Kazuya Fujihara
    Division of Endocrinology and Metabolism, Department of Internal Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki 305 8575, Japan
    J Diabetes Res 2015:507245. 2015
    ..To elucidate the levels of malondialdehyde-modified LDL (MDA-LDL)-related variables for predicting coronary artery stenosis (CAS) by coronary CT angiography (CCTA) in asymptomatic patients with type 2 diabetes (T2DM)...
  13. pmc Palmitate impairs and eicosapentaenoate restores insulin secretion through regulation of SREBP-1c in pancreatic islets
    Toyonori Kato
    Department of Internal Medicine Endocrinology and Metabolism, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Japan
    Diabetes 57:2382-92. 2008
    ..Chronic exposure to fatty acids causes beta-cell failure, often referred to as lipotoxicity. We investigated its mechanisms, focusing on contribution of SREBP-1c, a key transcription factor for lipogenesis...
  14. pmc Different Effects of Eicosapentaenoic and Docosahexaenoic Acids on Atherogenic High-Fat Diet-Induced Non-Alcoholic Fatty Liver Disease in Mice
    Noriko Suzuki-Kemuriyama
    Department of Internal Medicine Endocrinology and Metabolism, Faculty of Medicine, University of Tsukuba, 1 1 1 Tennodai, Tsukuba, Ibaraki 305 8575, Japan
    PLoS ONE 11:e0157580. 2016
    ..Both EPA and DHA could be effective for treatment of NAFLD and NASH. Meanwhile, the two major n-3 polyunsaturated fatty acids might differ in a relative contribution to pathological intermediate steps towards liver fibrosis. ..
  15. doi request reprint The selective PPARα modulator K-877 efficiently activates the PPARα pathway and improves lipid metabolism in mice
    Kenta Takei
    Department of Internal Medicine Endocrinology and Metabolism, Faculty of Medicine, University of Tsukuba, 1 1 1 Tennodai, Tsukuba, Ibaraki, Japan, 305 8575
    J Diabetes Investig . 2017
    ..The aim of the present study was to assess the effects of K-877 on lipid metabolism in vitro and in vivo compared with those of classical PPARα agonists...
  16. pmc Intestinal CREBH overexpression prevents high-cholesterol diet-induced hypercholesterolemia by reducing Npc1l1 expression
    Takuya Kikuchi
    Department of Internal Medicine Endocrinology and Metabolism, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki 305 8575, Japan
    Mol Metab 5:1092-1102. 2016
    ..Hepatic CREBH contributes to glucose and triglyceride metabolism by regulating fibroblast growth factor 21 (Fgf21) expression. However, the intestinal CREBH function remains unknown...
  17. ncbi request reprint Comparison of the Framingham risk score, UK Prospective Diabetes Study (UKPDS) Risk Engine, Japanese Atherosclerosis Longitudinal Study-Existing Cohorts Combine (JALS-ECC) and maximum carotid intima-media thickness for predicting coronary artery stenosis
    Kazuya Fujihara
    Division of Endocrinology and Metabolism, Department of Internal Medicine, Faculty of Medicine, University of Tsukuba
    J Atheroscler Thromb 21:799-815. 2014
    ....
  18. doi request reprint Dicer has a crucial role in the early stage of adipocyte differentiation, but not in lipid synthesis, in 3T3-L1 cells
    Yuri Fujimoto
    Department of Internal Medicine Metabolism and Endocrinology, Faculty of Medicine, University of Tsukuba, 1 1 1 Tennodai, Tsukuba, Ibaraki 305 8575, Japan
    Biochem Biophys Res Commun 420:931-6. 2012
    ..Thus, Dicer controls proadipogenic genes such as C/EBPα and PPARγ in the early, but not in the late, stage of adipogenesis via regulation of miRNA synthesis...
  19. doi request reprint Sterol regulatory element-binding protein-1 determines plasma remnant lipoproteins and accelerates atherosclerosis in low-density lipoprotein receptor-deficient mice
    Tadayoshi Karasawa
    Department of Internal Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Ibaraki, Japan
    Arterioscler Thromb Vasc Biol 31:1788-95. 2011
    ..The goal of this study was to evaluate the roles of SREBP-1 in dyslipidemia and atherosclerosis...
  20. doi request reprint Mouse Elovl-6 promoter is an SREBP target
    Shin Kumadaki
    Department of Internal Medicine Endocrinology and Metabolism, Graduate School of Comprehensive Human Sciences, University of Tsukuda, 1 1 1 Tennodai, Tsukuba, Ibaraki 305 8575, Japan
    Biochem Biophys Res Commun 368:261-6. 2008
    ..EMSA indicated that SRE-1 had higher affinity than SRE-2 for SREBP. ChIP assays confirmed in vivo binding of hepatic nuclear SREBP-1c protein. These data demonstrated that Elovl-6 is regulated directly and primarily by SREBP-1c...
  21. pmc CREB3L3 controls fatty acid oxidation and ketogenesis in synergy with PPARα
    Yoshimi Nakagawa
    Department of Internal Medicine Endocrinology and Metabolism, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki 305 8575, Japan
    Sci Rep 6:39182. 2016
    ..Furthermore, as KD-fed Creb3l3-/- mice exhibited severe fatty liver, activating inflammation, CREB3L3 could be a therapeutic target for NAFLD...
  22. doi request reprint Skeletal muscle-specific HMG-CoA reductase knockout mice exhibit rhabdomyolysis: A model for statin-induced myopathy
    Yoshinori Osaki
    Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki 305 8575, Japan Department of Internal Medicine Endocrinology and Metabolism, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki 305 8575, Japan
    Biochem Biophys Res Commun 466:536-40. 2015
    ....
  23. doi request reprint The up-regulation of microRNA-335 is associated with lipid metabolism in liver and white adipose tissue of genetically obese mice
    Noriko Nakanishi
    Department of Internal Medicine Endocrinology and Metabolism, Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1 1 1 Tennodai, Tsukuba, Ibaraki 305 8575, Japan
    Biochem Biophys Res Commun 385:492-6. 2009
    ..These findings provide the first evidence that the up-regulated expressions of miR-335 in liver and WAT of obese mice might contribute to the pathophysiology of obesity...
  24. doi request reprint The liver-enriched transcription factor CREBH is nutritionally regulated and activated by fatty acids and PPARalpha
    Hirosuke Danno
    Department of Internal Medicine Endocrinology and Metabolism, Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1 1 1 Tennodai, Tsukuba Ibaraki 305 8575, Japan
    Biochem Biophys Res Commun 391:1222-7. 2010
    ..Activation of CREBH at fasting through fatty acids and PPARalpha suggest that CREBH is involved in nutritional regulation...
  25. pmc Absence of Elovl6 attenuates steatohepatitis but promotes gallstone formation in a lithogenic diet-fed Ldlr(-/-) mouse model
    Motoko Kuba
    Department of Internal Medicine Endocrinology and Metabolism, Faculty of Medicine, University of Tsukuba, 1 1 1 Tennodai, Tsukuba, Ibaraki 305 8575, Japan
    Sci Rep 5:17604. 2015
    ....
  26. doi request reprint Ablation of Elovl6 protects pancreatic islets from high-fat diet-induced impairment of insulin secretion
    Nie Tang
    Department of Internal Medicine Endocrinology and Metabolism, Faculty of Medicine, University of Tsukuba, 1 1 1 Tennodai, Tsukuba, Ibaraki 305 8575, Japan
    Biochem Biophys Res Commun 450:318-23. 2014
    ..Our findings suggest that Elovl6 could be involved in insulin secretory capacity per β-cell and diabetes. ..
  27. ncbi request reprint Insulin inhibits apoptosis of macrophage cell line, THP-1 cells, via phosphatidylinositol-3-kinase-dependent pathway
    Kaoruko Tada Iida
    Division of Endocrinology and Metabolism, Department of Internal Medicine, Institute of Clinical Medicine, University of Tsukuba, Ibaraki, Japan
    Arterioscler Thromb Vasc Biol 22:380-6. 2002
    ..These mechanisms could be involved in the possible role of insulin in the development of atherosclerosis...
  28. pmc Hyperlipidemia and hepatitis in liver-specific CREB3L3 knockout mice generated using a one-step CRISPR/Cas9 system
    Yoshimi Nakagawa
    Department of Internal Medicine Endocrinology and Metabolism, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki 305 8575, Japan
    Sci Rep 6:27857. 2016
    ..These results provide new evidence regarding the hepatic CREB3L3 role in plasma triglyceride metabolism and hepatic and intestinal CREB3L3 contributions to cholesterol metabolism. ..
  29. ncbi request reprint Carotid artery plaque and LDL-to-HDL cholesterol ratio predict atherosclerotic status in coronary arteries in asymptomatic patients with type 2 diabetes mellitus
    Kazuya Fujihara
    Division of Endocrinology and Metabolism, Department of Internal Medicine, Faculty of Medicine, University of Tsukuba, Japan
    J Atheroscler Thromb 20:452-64. 2013
    ..To investigate the clinical predictors of coronary atherosclerosis and to assess the utility of maximum-IMT for predicting coronary atherosclerosis in asymptomatic type 2 diabetic patients...
  30. doi request reprint Identification of human ELOVL5 enhancer regions controlled by SREBP
    Akito Shikama
    Nutrigenomics Research Group, Faculty of Medicine, University of Tsukuba, Japan
    Biochem Biophys Res Commun 465:857-63. 2015
    ..Through these findings, we clarified the molecular mechanism how SREBP activates ELOVL5, an important regulator of de novo lipogenesis...
  31. ncbi request reprint Involvement of glomerular SREBP-1c in diabetic nephropathy
    Naomi Ishigaki
    Department of Internal Medicine Endocrinology and Metabolism, Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1 1 1 Tennodai, Tsukuba, Ibaraki 305 8575, Japan
    Biochem Biophys Res Commun 364:502-8. 2007
    ..These data suggest that activation of glomerular SREBP-1c could contribute to emergence and/or progression of diabetic nephropathy...
  32. ncbi request reprint Cross-talk between peroxisome proliferator-activated receptor (PPAR) alpha and liver X receptor (LXR) in nutritional regulation of fatty acid metabolism. II. LXRs suppress lipid degradation gene promoters through inhibition of PPAR signaling
    Tomohiro Ide
    Department of Internal Medicine, Institute of Clinical Medicine, University of Tsukuba, Ibaraki 305 8575, Japan
    Mol Endocrinol 17:1255-67. 2003
    ....
  33. ncbi request reprint Cross-talk between peroxisome proliferator-activated receptor (PPAR) alpha and liver X receptor (LXR) in nutritional regulation of fatty acid metabolism. I. PPARs suppress sterol regulatory element binding protein-1c promoter through inhibition of LXR sig
    Tomohiro Yoshikawa
    Department of Metabolic Diseases, Graduate School of Agricultural and Life Sciences, University of Tokyo, Bunkyo ku, Japan
    Mol Endocrinol 17:1240-54. 2003
    ..These data suggest that PPARalpha activation can suppress LXR-SREBP-1c pathway through reduction of LXR/RXR formation, proposing a novel transcription factor cross-talk between LXR and PPARalpha in hepatic lipid homeostasis...
  34. ncbi request reprint NeuroD and reaggregation induce beta-cell specific gene expression in cultured hepatocytes
    Shigeru Yatoh
    Section on Islet Transplantation and Cell Biology, Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215, USA
    Diabetes Metab Res Rev 23:239-49. 2007
    ..Our goal was to convert adult mouse hepatocytes to pancreatic beta-cells...