M Aoki

Summary

Affiliation: Yamanouchi Pharmaceutical Co
Country: Japan

Publications

  1. ncbi request reprint A novel phosphodiesterase type 4 inhibitor, YM976 (4-(3-chlorophenyl)-1,7-diethylpyrido[2,3-d]pyrimidin-2(1H)-one), with little emetogenic activity
    M Aoki
    Inflammation Research, Pharmacology Laboratories, Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Co, Ltd, Ibaraki 305 8585, Japan
    J Pharmacol Exp Ther 295:255-60. 2000
  2. ncbi request reprint Effect of a novel anti-inflammatory compound, YM976, on antigen-induced eosinophil infiltration into the lungs in rats, mice, and ferrets
    M Aoki
    Inflammation Research, Pharmacology Laboratories, Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Co, Ltd, Tsukuba shi, Ibaraki, Japan
    J Pharmacol Exp Ther 295:1149-55. 2000
  3. ncbi request reprint Antiasthmatic effect of YM976, a novel PDE4 inhibitor, in guinea pigs
    M Aoki
    Inflammation Research Pharmacology Laboratories, Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Co, Ltd, Tsukuba shi, Ibaraki, Japan
    J Pharmacol Exp Ther 297:165-73. 2001
  4. ncbi request reprint Studies on mechanisms of low emetogenicity of YM976, a novel phosphodiesterase type 4 inhibitor
    M Aoki
    Inflammation Research, Pharmacology Laboratories, Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Co, Ltd, Ibaraki, Japan
    J Pharmacol Exp Ther 298:1142-9. 2001
  5. ncbi request reprint Coumarin and chromen-4-one analogues as tautomerase inhibitors of macrophage migration inhibitory factor: discovery and X-ray crystallography
    M Orita
    Yamanouchi Pharmaceutical Company Ltd, 21 Miyukigaoka, Tsukuba Science City 305 8585, Japan
    J Med Chem 44:540-7. 2001
  6. ncbi request reprint Inhibition of NFkappaB activation using cis-element 'decoy' of NFkappaB binding site reduces neointimal formation in porcine balloon-injured coronary artery model
    K Yamasaki
    Department of Geriatric Medicine, Osaka University Medical School, Suita, Japan
    Gene Ther 10:356-64. 2003
  7. ncbi request reprint Impaired endothelial dysfunction in diabetes mellitus rats was restored by oral administration of prostaglandin I2 analogue
    K Matsumoto
    Department of Geriatric Medicine, Graduate School of Medicine, Osaka University, 2 2 Yamada oka, Suita 565 0871, Japan
    J Endocrinol 175:217-23. 2002
  8. ncbi request reprint Molecular strategy using cis-element 'decoy' of E2F binding site inhibits neointimal formation in porcine balloon-injured coronary artery model
    T Nakamura
    Department of Geriatric Medicine, Osaka University Medical School, Suita, Japan
    Gene Ther 9:488-94. 2002
  9. ncbi request reprint The growth-promoting activity of the Bad protein in chicken embryo fibroblasts requires binding to protein 14-3-3
    D J Maslyar
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, BCC239 La Jolla, California, USA
    Oncogene 20:5087-92. 2001
  10. ncbi request reprint Angiotensin converting enzyme inhibitor restrains inflammation-induced vascular injury in mice
    M Akishita
    Cardiovascular Research, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA
    J Hypertens 19:1083-8. 2001

Collaborators

  • S Kubo
  • L Zhang
  • Tetsuji Okada
  • Hirokazu Suzuki
  • Masakazu Tanaka
  • T Yamada
  • T Ogihara
  • R Morishita
  • Y Kaneda
  • K Yamasaki
  • T Nakamura
  • K Matsumoto
  • T Miyake
  • N Hashiya
  • H Sakonjo
  • T Asai
  • H Nakagami
  • D J Maslyar
  • K Masubuchi
  • M Horiuchi
  • A Manaka
  • M Orita
  • M Akishita
  • H Nakashima
  • K Kataoka
  • K Tanemoto
  • T Kawasaki
  • M Oishi
  • H Makino
  • M Shimizu
  • A Moriguchi
  • J Higaki
  • N Tsuboniwa
  • N Tomita
  • A Tanaka
  • E Mizuguchi
  • H Kurihara
  • Y Toda
  • T Watanabe
  • T Inoue
  • S Yamamoto
  • Y Satoh
  • P K Vogt
  • G Shirakami
  • T Ikeda
  • K Takayama
  • N Katayama
  • Y Yamagiwa
  • S Fujita
  • T Yamazaki
  • K Toba
  • N Shimma
  • I Horii
  • M Sato
  • Y Taniyama
  • Y Yamane
  • M Kohchi
  • H Shirai
  • M Iwai
  • M Takeuchi
  • H Sakashita
  • K Yamamoto
  • M Sakaitani
  • O Kondoh
  • L Wu
  • S Nakaike
  • K Kobayashi
  • N Seki

Detail Information

Publications14

  1. ncbi request reprint A novel phosphodiesterase type 4 inhibitor, YM976 (4-(3-chlorophenyl)-1,7-diethylpyrido[2,3-d]pyrimidin-2(1H)-one), with little emetogenic activity
    M Aoki
    Inflammation Research, Pharmacology Laboratories, Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Co, Ltd, Ibaraki 305 8585, Japan
    J Pharmacol Exp Ther 295:255-60. 2000
    ..In conclusion, YM976 is a novel and orally active PDE4 inhibitor and possesses a good separation of emetogenicity from anti-inflammatory activity...
  2. ncbi request reprint Effect of a novel anti-inflammatory compound, YM976, on antigen-induced eosinophil infiltration into the lungs in rats, mice, and ferrets
    M Aoki
    Inflammation Research, Pharmacology Laboratories, Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Co, Ltd, Tsukuba shi, Ibaraki, Japan
    J Pharmacol Exp Ther 295:1149-55. 2000
    ..In conclusion, YM976 is a promising drug for the treatment of diseases involving eosinophil activity, such as asthma...
  3. ncbi request reprint Antiasthmatic effect of YM976, a novel PDE4 inhibitor, in guinea pigs
    M Aoki
    Inflammation Research Pharmacology Laboratories, Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Co, Ltd, Tsukuba shi, Ibaraki, Japan
    J Pharmacol Exp Ther 297:165-73. 2001
    ..In conclusion, YM976 may have potential therapeutic value in the treatment of asthma through its anti-inflammatory activities...
  4. ncbi request reprint Studies on mechanisms of low emetogenicity of YM976, a novel phosphodiesterase type 4 inhibitor
    M Aoki
    Inflammation Research, Pharmacology Laboratories, Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Co, Ltd, Ibaraki, Japan
    J Pharmacol Exp Ther 298:1142-9. 2001
    ..In conclusion, YM976 shows an apparent dissociation between its anti-inflammatory effects and emetogenicity, perhaps because of the poor brain penetration...
  5. ncbi request reprint Coumarin and chromen-4-one analogues as tautomerase inhibitors of macrophage migration inhibitory factor: discovery and X-ray crystallography
    M Orita
    Yamanouchi Pharmaceutical Company Ltd, 21 Miyukigaoka, Tsukuba Science City 305 8585, Japan
    J Med Chem 44:540-7. 2001
    ..One of these small, drug-like molecules has been cocrystallized with MIF and binds to the active site for tautomerase activity. Molecular modeling also suggests that the other hit compounds can bind in a similar fashion...
  6. ncbi request reprint Inhibition of NFkappaB activation using cis-element 'decoy' of NFkappaB binding site reduces neointimal formation in porcine balloon-injured coronary artery model
    K Yamasaki
    Department of Geriatric Medicine, Osaka University Medical School, Suita, Japan
    Gene Ther 10:356-64. 2003
    ..Here, we report the successful in vivo transfer of NFkappaB decoy ODN using a hydrogel catheter to inhibit vascular lesion formation in balloon-injured porcine coronary artery...
  7. ncbi request reprint Impaired endothelial dysfunction in diabetes mellitus rats was restored by oral administration of prostaglandin I2 analogue
    K Matsumoto
    Department of Geriatric Medicine, Graduate School of Medicine, Osaka University, 2 2 Yamada oka, Suita 565 0871, Japan
    J Endocrinol 175:217-23. 2002
    ..Increased local vascular HGF production by a PGI(2) analogue may prevent endothelial injury, potentially resulting in the improvement of endothelial dysfunction...
  8. ncbi request reprint Molecular strategy using cis-element 'decoy' of E2F binding site inhibits neointimal formation in porcine balloon-injured coronary artery model
    T Nakamura
    Department of Geriatric Medicine, Osaka University Medical School, Suita, Japan
    Gene Ther 9:488-94. 2002
    ..Here, we report the successful in vivo transfer of E2F decoy ODN using a hydrogel catheter to inhibit vascular lesion formation in balloon-injured porcine coronary artery without any apparent side-effects...
  9. ncbi request reprint The growth-promoting activity of the Bad protein in chicken embryo fibroblasts requires binding to protein 14-3-3
    D J Maslyar
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, BCC239 La Jolla, California, USA
    Oncogene 20:5087-92. 2001
    ..These results suggest that phosphorylated Bad promotes cell growth and in oncogenic transformation may contribute to the neoplastic phenotype of the cell...
  10. ncbi request reprint Angiotensin converting enzyme inhibitor restrains inflammation-induced vascular injury in mice
    M Akishita
    Cardiovascular Research, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA
    J Hypertens 19:1083-8. 2001
    ..72+/-0.09). CONCLUSIONS: This study provides evidence that ACE plays a role in cuff-induced neointimal thickening in mice. Nitric oxide may contribute, at least in part, to the inhibitory effects of perindopril...
  11. ncbi request reprint 2-Acylimino-3H-thiazoline derivatives: a novel template for platelet GPIIb/IIIa receptor antagonists
    A Manaka
    Taisho Pharmaceutical Co. Ltd, Medicinal Research Laboratories, Omiya-shi, Saitama, Japan
    Bioorg Med Chem Lett 11:1031-5. 2001
    ..5 +/- 5.8 microM)...
  12. ncbi request reprint Mitogenic and antiapoptotic actions of hepatocyte growth factor through ERK, STAT3, and AKT in endothelial cells
    H Nakagami
    Department of Geriatric Medicine, Division of Gene Therapy Science, Osaka University, Osaka, Japan
    Hypertension 37:581-6. 2001
    ..These findings provide new perspectives in the role of HGF in cardiovascular disease...
  13. ncbi request reprint Synthesis and antifungal activities of novel 1,3-beta-D-glucan synthase inhibitors. Part 1
    K Masubuchi
    Department of Chemistry, Nippon Roche Research Center, Kanagawa, Japan
    Bioorg Med Chem Lett 11:395-8. 2001
    ..D-Ornithine derivative (10) showed improved antifungal activity in the systemic candidiasis model in mice and reduced hepatotoxicity in vitro, as compared with 1...
  14. ncbi request reprint Prevention of abdominal aortic aneurysms by simultaneous inhibition of NFkappaB and ets using chimeric decoy oligonucleotides in a rabbit model
    T Miyake
    Division of Clinical Gene Therapy, Graduate School of Medicine, Osaka University, Suita, Osaka 565 0871, Japan
    Gene Ther 13:695-704. 2006
    ..Further modification of chimeric decoy ODN would be useful to treat AAA as a decoy-based therapy...