Shoichi Hazama

Summary

Affiliation: Yamaguchi University
Country: Japan

Publications

  1. ncbi request reprint Efficacy of orally administered superfine dispersed lentinan (beta-1,3-glucan) for the treatment of advanced colorectal cancer
    Shoichi Hazama
    Department of Surgery II, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi 755 8505, Japan
    Anticancer Res 29:2611-7. 2009
  2. ncbi request reprint UDP-glucuronosyltransferase (UGT) 1A1*28 polymorphism-directed phase II study of irinotecan with 5'-deoxy-5-fluorouridine (5'-DFUR) for metastatic colorectal cancer
    Shinsuke Kanekiyo
    Department of Digestive Surgery and Surgical Oncology Surgery II, Yamaguchi University Graduate School of Medicine, 1 1 1 Minami kogushi, Ube, Yamaguchi 755 8505, Japan
    Anticancer Res 33:3423-30. 2013
  3. ncbi request reprint Novel Indications for Surgical Resection of Metachronous Lung Metastases From Pancreatic Cancer After Curative Resection
    Masao Nakajima
    Department of Gastroenterological, Breast and Endocrine Surgery, Yamaguchi University Graduate School of Medicine, Yamaguchi, Japan
    J Clin Gastroenterol . 2016
  4. doi request reprint Dendritic cells transfected with heat-shock protein 70 messenger RNA for patients with hepatitis C virus-related hepatocellular carcinoma: a phase 1 dose escalation clinical trial
    Yoshinari Maeda
    Department of Digestive Surgery and Surgical Oncology, Yamaguchi University Graduate School of Medicine, 1 1 1 Minami kogushi, Ube, Yamaguchi, 755 8505, Japan
    Cancer Immunol Immunother 64:1047-56. 2015
  5. ncbi request reprint Preoperative serum methylation signature as prognostic tool after curative hepatectomy in patients with hepatocellular carcinoma
    Shinsuke Kanekiyo
    Department of Digestive Surgery and Surgical Oncology Surgery II, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi, Japan
    Anticancer Res 35:997-1007. 2015
  6. doi request reprint UGT1A1*6, 1A7*3, and 1A9*22 genotypes predict severe neutropenia in FOLFIRI-treated metastatic colorectal cancer in two prospective studies in Japan
    Shoichi Hazama
    Department of Digestive Surgery and Surgical Oncology Surgery II, Yamaguchi University Graduate School of Medicine, Ube, Japan
    Cancer Sci 104:1662-9. 2013
  7. pmc Prediction of the efficacy of immunotherapy by measuring the integrity of cell-free DNA in plasma in colorectal cancer
    Masahiro Kitahara
    Department of Gastroenterological, Breast and Endocrine Surgery, Yamaguchi University Graduate School of Medicine, Ube, Japan
    Cancer Sci . 2016
  8. doi request reprint Cetuximab strongly enhances immune cell infiltration into liver metastatic sites in colorectal cancer
    Yuka Inoue
    Department of Gastroenterological, Breast and Endocrine Surgery, Yamaguchi University Graduate School of Medicine, Ube, Japan
    Cancer Sci . 2017
  9. pmc Perioperative Microbiologic Monitoring of Sputum on Postoperative Day One as a Predictor of Pneumonia After Hepatectomy
    Kazuhiko Sakamoto
    Department of Digestive Surgery and Surgical Oncology, Yamaguchi University Graduate School of Medicine, 1 1 1, Minami Kogushi, Ube, Yamaguchi, 755 8505, Japan
    J Gastrointest Surg 19:1662-7. 2015
  10. ncbi request reprint Predictive biomarkers for the outcome of vaccination of five therapeutic epitope peptides for colorectal cancer
    Shoichi Hazama
    Department of Digestive Surgery and Surgical Oncology, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi, Japan
    Anticancer Res 34:4201-5. 2014

Collaborators

Detail Information

Publications40

  1. ncbi request reprint Efficacy of orally administered superfine dispersed lentinan (beta-1,3-glucan) for the treatment of advanced colorectal cancer
    Shoichi Hazama
    Department of Surgery II, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi 755 8505, Japan
    Anticancer Res 29:2611-7. 2009
    ..To investigate the safety and effectiveness of SDL, a multi center clinical study in patients with advanced colorectal cancer was conducted...
  2. ncbi request reprint UDP-glucuronosyltransferase (UGT) 1A1*28 polymorphism-directed phase II study of irinotecan with 5'-deoxy-5-fluorouridine (5'-DFUR) for metastatic colorectal cancer
    Shinsuke Kanekiyo
    Department of Digestive Surgery and Surgical Oncology Surgery II, Yamaguchi University Graduate School of Medicine, 1 1 1 Minami kogushi, Ube, Yamaguchi 755 8505, Japan
    Anticancer Res 33:3423-30. 2013
    ..We performed a phase II study of irinotecan with 5'-deoxy-5-fluorouridine (5'-DFUR) for metastatic colorectal cancer based on UDP-glucuronosyltransferase (UGT) 1A1 polymorphism...
  3. ncbi request reprint Novel Indications for Surgical Resection of Metachronous Lung Metastases From Pancreatic Cancer After Curative Resection
    Masao Nakajima
    Department of Gastroenterological, Breast and Endocrine Surgery, Yamaguchi University Graduate School of Medicine, Yamaguchi, Japan
    J Clin Gastroenterol . 2016
    ..In addition, it is possible that MLM of <16 mm or primary stage I tumors are novel criteria...
  4. doi request reprint Dendritic cells transfected with heat-shock protein 70 messenger RNA for patients with hepatitis C virus-related hepatocellular carcinoma: a phase 1 dose escalation clinical trial
    Yoshinari Maeda
    Department of Digestive Surgery and Surgical Oncology, Yamaguchi University Graduate School of Medicine, 1 1 1 Minami kogushi, Ube, Yamaguchi, 755 8505, Japan
    Cancer Immunol Immunother 64:1047-56. 2015
    ..This suggested that HSP70 could be a molecular target for treatment of HCC...
  5. ncbi request reprint Preoperative serum methylation signature as prognostic tool after curative hepatectomy in patients with hepatocellular carcinoma
    Shinsuke Kanekiyo
    Department of Digestive Surgery and Surgical Oncology Surgery II, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi, Japan
    Anticancer Res 35:997-1007. 2015
    ....
  6. doi request reprint UGT1A1*6, 1A7*3, and 1A9*22 genotypes predict severe neutropenia in FOLFIRI-treated metastatic colorectal cancer in two prospective studies in Japan
    Shoichi Hazama
    Department of Digestive Surgery and Surgical Oncology Surgery II, Yamaguchi University Graduate School of Medicine, Ube, Japan
    Cancer Sci 104:1662-9. 2013
    ..In this regard, haplotype analyses should substantially impact the prediction of severe hematological toxicities of FOLFIRI. (..
  7. pmc Prediction of the efficacy of immunotherapy by measuring the integrity of cell-free DNA in plasma in colorectal cancer
    Masahiro Kitahara
    Department of Gastroenterological, Breast and Endocrine Surgery, Yamaguchi University Graduate School of Medicine, Ube, Japan
    Cancer Sci . 2016
    ..In conclusion, the integrity of plasma cfDNA may provide important clinical information and may be a useful predictive biomarker of the outcome of immunotherapy in mCRC. This article is protected by copyright. All rights reserved...
  8. doi request reprint Cetuximab strongly enhances immune cell infiltration into liver metastatic sites in colorectal cancer
    Yuka Inoue
    Department of Gastroenterological, Breast and Endocrine Surgery, Yamaguchi University Graduate School of Medicine, Ube, Japan
    Cancer Sci . 2017
    ..As such, the immune-related mechanism of action of cetuximab may enhance the efficacy of combination therapy, such as chemotherapy and immunotherapy using therapeutic peptides. This article is protected by copyright. All rights reserved...
  9. pmc Perioperative Microbiologic Monitoring of Sputum on Postoperative Day One as a Predictor of Pneumonia After Hepatectomy
    Kazuhiko Sakamoto
    Department of Digestive Surgery and Surgical Oncology, Yamaguchi University Graduate School of Medicine, 1 1 1, Minami Kogushi, Ube, Yamaguchi, 755 8505, Japan
    J Gastrointest Surg 19:1662-7. 2015
    ..The purpose of this study was to retrospectively evaluate microbial examination of sputum on postoperative day one (POD1) and to determine risk factors for postoperative pneumonia (POP) after hepatectomy...
  10. ncbi request reprint Predictive biomarkers for the outcome of vaccination of five therapeutic epitope peptides for colorectal cancer
    Shoichi Hazama
    Department of Digestive Surgery and Surgical Oncology, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi, Japan
    Anticancer Res 34:4201-5. 2014
    ..The objective of this analysis was to investigate predictive biomarkers for the prior selection of patients who are likely to have clinical benefit from such therapy...
  11. pmc Adoptive immunotherapy with MUC1-mRNA transfected dendritic cells and cytotoxic lymphocytes plus gemcitabine for unresectable pancreatic cancer
    Yoshitaro Shindo
    Department of Digestive Surgery and Surgical Oncology Department of Surgery II, Yamaguchi University Graduate School of Medicine, 1 1 1 Minami kogushi, Ube, Yamaguchi 755 8505, Japan
    J Transl Med 12:175. 2014
    ..Therefore, in the present study, we performed combination therapy with AIT and GEM for patients with unresectable or recurrent pancreatic cancer...
  12. ncbi request reprint Combination phase II study of weekly paclitaxel and 5'-DFUR for unresectable or recurrent gastric cancer
    Shigefumi Yoshino
    Department of Digestive Surgery and Surgical Oncology, Graduate School of Medicine, Yamaguchi University, Ube, Japan
    Anticancer Res 33:2629-33. 2013
    ..To evaluate the efficacy and safety of their combination, we conducted a combination phase II study of paclitaxel and 5'-DFUR in patients with unresectable or recurrent gastric cancer who had received up to one prior chemotherapy...
  13. pmc Association of tumor necrosis factor-α polymorphism with chemotherapy-induced oral mucositis in patients with esophageal cancer
    Kazuhiko Sakamoto
    Department of Gastroenterological, Breast and Endocrine Surgery, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi 755 8505, Japan
    Mol Clin Oncol 6:125-129. 2017
    ..8; P=0.043). This difference in risk was replicated in the validation cohort. Thus, the TT genotype of TNF-α rs1799964 may be a predictor of chemotherapy-induced OM in patients with esophageal cancer...
  14. pmc A phase I clinical trial of vaccination with KIF20A-derived peptide in combination with gemcitabine for patients with advanced pancreatic cancer
    Nobuaki Suzuki
    Departments of Digestive Surgery and Surgical Oncology Surgery II, Yamaguchi University Graduate School of Medicine, Yamaguchi Department of Immunology, Juntendo University School of Medicine, Tokyo, Japan
    J Immunother 37:36-42. 2014
    ..These results suggest that this combination therapy will be feasible and promising for the treatment of advanced pancreatic cancer...
  15. doi request reprint FcγR and EGFR polymorphisms as predictive markers of cetuximab efficacy in metastatic colorectal cancer
    Yuka Inoue
    Department of Digestive Surgery and Surgical Oncology Surgery II, Yamaguchi University Graduate School of Medicine, 1 1 1 Minami kogushi, Ube, Yamaguchi, 755 8505, Japan
    Mol Diagn Ther 18:541-8. 2014
    ....
  16. pmc Calreticulin is highly expressed in pancreatic cancer stem-like cells
    Satoshi Matsukuma
    Department of Gastroenterological, Breast and Endocrine Surgery, Yamaguchi University Graduate School of Medicine, Ube, Japan
    Cancer Sci 107:1599-1609. 2016
    ..This novel biomarker can be considered as a therapeutic target for cancer immunotherapy...
  17. ncbi request reprint Efficacy and Safety of Biweekly Docetaxel in Combination with Nedaplatin as Second-line Chemotherapy for Unresectable or Recurrent Esophageal Cancer
    Shinsuke Kanekiyo
    Department of Gastroenterological, Breast and Endocrine Surgery, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi, Japan
    Anticancer Res 36:1923-7. 2016
    ..The aim of this study was to retrospectively investigate the efficacy and safety of docetaxel and nedaplatin combination chemotherapy for unresectable or recurrent esophageal cancer in an outpatient setting...
  18. doi request reprint A Phase II Study of XELOX and Cetuximab as First-Line Therapy in Patients With KRAS Wild Type Metastatic Colorectal Cancer (FLEET2 Study)
    Shoichi Hazama
    Department of Gastroenterological, Breast and Endocrine Surgery, Yamaguchi University, Graduate School of Medicine, Ube, Japan
    Clin Colorectal Cancer 15:329-336. 2016
    ....
  19. doi request reprint MicroRNA-6826 and -6875 in plasma are valuable non‑invasive biomarkers that predict the efficacy of vaccine treatment against metastatic colorectal cancer
    Taiki Kijima
    Department of Gastroenterological, Breast and Endocrine Surgery, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi 755 8505, Japan
    Oncol Rep . 2016
    ....
  20. doi request reprint Intraoperative dissemination during gastrectomy for gastric cancer associated with serosal invasion
    Yukio Tokumitsu
    Department of Digestive Surgery and Surgical Oncology, Yamaguchi University, Graduate School of Medicene, 1 1 1 Minamikogushi, Ube, Yamaguchi, 755 8505, Japan
    Surg Today 45:746-51. 2015
    ..Free cancer cells shed from the serosal surface of gastric cancer result in peritoneal dissemination. The aim of this study was to clarify the extent of tumor cell implantation due to surgical manipulation during gastrectomy...
  21. pmc A novel system for predicting the toxicity of irinotecan based on statistical pattern recognition with UGT1A genotypes
    Ryouichi Tsunedomi
    Department of Digestive Surgery and Surgical Oncology, Yamaguchi University Graduate School of Medicine, Yamaguchi 755 8505, Japan
    Int J Oncol 45:1381-90. 2014
    ....
  22. doi request reprint Possible involvement of Wnt11 in colorectal cancer progression
    Mitsuaki Nishioka
    Department of Oncology and Laboratory Medicine, Yamaguchi University Graduate School of Medicine, Ube, Japan
    Mol Carcinog 52:207-17. 2013
    ..0005). The expression levels of Wnt11 mRNA were correlated with those of FZD7 mRNA (P < 0.0001). These data suggest that Wnt11 may play an important role in CRC progression...
  23. ncbi request reprint Improvement of QOL and prognosis by treatment of superfine dispersed lentinan in patients with advanced gastric cancer
    Shigefumi Yoshino
    Department of Surgery II, Yamaguchi University Graduate School of Medicine, Yamaguchi, Japan
    Hepatogastroenterology 57:172-7. 2010
    ..Recently, superfine dispersed lentinan--an oral formulation--has become clinically available. In order to evaluate the efficacy of superfine dispersed lentinan, was conducted multicenter clinical study...
  24. ncbi request reprint Highly sensitive stool DNA testing of Fusobacterium nucleatum as a marker for detection of colorectal tumours in a Japanese population
    Yutaka Suehiro
    Department of Oncology and Laboratory Medicine, Yamaguchi University Graduate School of Medicine, Ube, Japan
    Ann Clin Biochem . 2016
    ..Therefore, we developed a droplet digital polymerase chain reaction (PCR) assay for detecting Fusobacterium nucleatum in stool and investigated its clinical utility in the management of colorectal tumours in a Japanese population...
  25. ncbi request reprint Combination immunotherapy with 4-1BB activation and PD-1 blockade enhances antitumor efficacy in a mouse model of subcutaneous tumor
    Yoshitaro Shindo
    Department of Digestive Surgery and Surgical Oncology, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi, Japan
    Anticancer Res 35:129-36. 2015
    ....
  26. pmc An accurate prognostic staging system for hepatocellular carcinoma patients after curative hepatectomy
    Yukio Tokumitsu
    Department of Digestive Surgery and Surgical Oncology, Yamaguchi University Graduate School of Medicine, Yamaguchi, Japan
    Int J Oncol 46:944-52. 2015
    ..These results suggest that the PS score serves as a simple, accurate predictor for the prognosis of HCC patients after hepatectomy...
  27. pmc A stem cell medium containing neural stimulating factor induces a pancreatic cancer stem-like cell-enriched population
    Yusaku Watanabe
    Department of Digestive Surgery and Surgical Oncology, Yamaguchi University School of Medicine, Ube, Yamaguchi 755 8505, Japan
    Int J Oncol 45:1857-66. 2014
    ..The CSLC population was enriched approximately 100-fold with this method. Our culture method may contribute to the precise analysis of CSCs and thus support the establishment of CSC-targeting therapy. ..
  28. pmc A novel cancer vaccine strategy with combined IL-18 and HSV-TK gene therapy driven by the hTERT promoter in a murine colorectal cancer model
    Kosuke Higashi
    Department of Digestive Surgery and Surgical Oncology, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi 755 8505, Japan
    Int J Oncol 45:1412-20. 2014
    ..These data suggest that the IL-18 and suicide gene therapy can elicit antitumor specific immunity. In conclusion, gene therapy with IL-18 and HSV-TK plasmid vector driven by the hTERT promoter may be useful for cancer vaccination. ..
  29. pmc A phase I study of combination vaccine treatment of five therapeutic epitope-peptides for metastatic colorectal cancer; safety, immunological response, and clinical outcome
    Shoichi Hazama
    Department of Digestive Surgery and Surgical Oncology, Yamaguchi University Graduate School of Medicine, 1 1 1 Minami kogushi, Ube, Yamaguchi, Japan
    J Transl Med 12:63. 2014
    ....
  30. ncbi request reprint Suppressive effects of cyclophosphamide and gemcitabine on regulatory T-cell induction in vitro
    Shin Kan
    Department of Digestive Surgery and Surgical Oncology, Yamaguchi University Graduate School of Medicine, 1 1 1 Minami kogushi, Ube City, Yamaguchi Prefecture, 755 8505, Japan
    Anticancer Res 32:5363-9. 2012
    ..Inhibition of CD4(+)FOXP3(+) regulatory T-cell (Treg) activity may be important for successful cancer immunotherapy. We investigated the suppressive effects of several chemotherapeutic agents on Treg induction in vitro...
  31. pmc Cancer stem-like sphere cells induced from de-differentiated hepatocellular carcinoma-derived cell lines possess the resistance to anti-cancer drugs
    Noriaki Hashimoto
    Department of Digestive Surgery and Surgical Oncology, Yamaguchi University Graduate School of Medicine, 1 1 1 Minami kogushi, Ube, Yamaguchi 755 8505, Japan
    BMC Cancer 14:722. 2014
    ..In this study, we induced cancer stem-like cells from hepatocellular carcinoma (HCC) cell lines using a unique medium, and examined their potential for resistance to anti-cancer drugs...
  32. pmc Relationship between cytokine gene polymorphisms and risk of postoperative pneumonia with esophageal cancer
    Kazuhiko Sakamoto
    Department of Digestive Surgery and Surgical Oncology, Yamaguchi University Graduate School of Medicine, 1 1 1 Minami kogushi, Ube, Yamaguchi, 755 8505, Japan
    J Gastrointest Surg 18:1247-53. 2014
    ..We retrospectively evaluated the relationship between cytokine gene polymorphisms and development of postoperative pneumonia after esophagectomy...
  33. pmc A phase ΙI clinical trial of peptide cocktail therapy for patients with advanced pancreatic cancer: VENUS-PC study
    Nobuaki Suzuki
    Department of Gastroenterological, Breast and Endocrine Surgery, Yamaguchi University Graduate School of Medicine, Ube, Japan
    Cancer Sci . 2016
    ..This article is protected by copyright. All rights reserved...
  34. ncbi request reprint Phase II multicenter study of second-line FOLFIRI plus cetuximab (FLIER) in patients with KRAS wild-type metastatic colorectal cancer: Final analysis of survival and additional analysis of BRAF, PI3CA mutations
    Yasuhiro Miyake
    Minoh City Hospital, Minoh, Japan Kansai Medical University Hirakata Hospital, Hirakata, Japan Yamaguchi University Graduate School of Medicine, Ube, Japan Kagawa University, Kida, Japan Osaka General Medical Center, Osaka, Japan Ibaraki Prefectural Central Hospital, Kasama, Japan Ishikawa Prefectural Central Hospital, Kanazawa, Japan Sakai Municipal Hospital, Sakai, Japan Kitakyushu General Hospital, Kitakyusyu, Japan Nagoya University Graduate School of Medicine, Nagoya, Japan Osaka National Hospital, Osaka, Japan
    J Clin Oncol 30:481. 2012
    ..Since mutations in codons 12 and 13 of the KRAS gene predict lack of response to Cetuximab, mutations of V600E BRAF and PI3CA have been controversial...
  35. pmc A phase ΙI study of five peptides combination with oxaliplatin-based chemotherapy as a first-line therapy for advanced colorectal cancer (FXV study)
    Shoichi Hazama
    Department of Digestive Surgery and Surgical Oncology, Yamaguchi University Graduate School of Medicine, Ube, Japan
    J Transl Med 12:108. 2014
    ..To evaluate clinical benefits of cancer vaccination treatment, we conducted a phase II trial using the same peptides in combination with oxaliplatin-based chemotherapy as a first-line therapy...
  36. ncbi request reprint [A patient with intestinal gastrointestinal stromal tumor refractory to molecular targeted but whose quality of life improved after palliative surgery]
    Chiyo Nakasuga
    Dept of Digestive Surgery and Surgical Oncology, Yamaguchi University Graduate School of Medicine, Japan
    Gan To Kagaku Ryoho 39:1902-4. 2012
    ..After the operation, the general condition of the patient improved, and his ECOG PS was maintained as 1 for at least 4 months. Palliative resection may improve QOL...
  37. ncbi request reprint Impact of chemotherapy for colorectal cancer on regulatory T-cells and tumor immunity
    Kazunari Maeda
    Department of Digestive Surgery and Surgical Oncology, Yamaguchi University Graduate School of Medicine, 1 1 1 Minamikogushi, Ube City, Yamaguchi Prefecture 755 8505, Japan
    Anticancer Res 31:4569-74. 2011
    ..The purpose of the present study was to determine how oxaliplatin plus infusional 5-fluorouracil and leucovorin (FOLFOX) and irinotecan plus infusional 5-fluorouracil and leucovorin (FOLFIRI) affect Tregs and other immune effectors...
  38. doi request reprint Phase I study of irinotecan and doxifluridine for metastatic colorectal cancer focusing on the UGT1A1*28 polymorphism
    Shoichi Hazama
    Department of Digestive Surgery and Surgical Oncology Surgery II, Yamaguchi University Graduate School of Medicine, Yamaguchi, Japan
    Cancer Sci 101:722-7. 2010
    ..The gene polymorphism should be considered when determining the precise recommended doses to be administered in phase I studies...
  39. pmc Combined adjuvants of poly(I:C) plus LAG-3-Ig improve antitumor effects of tumor-specific T cells, preventing their exhaustion
    Yosuke Kano
    Department of Immunology, Yamaguchi University Graduate School of Medicine, Ube, Japan
    Cancer Sci 107:398-406. 2016
    ..Taken together, the results of the current study show that the combined adjuvants of poly(I:C) plus LAG-3-Ig with tumor peptide vaccine induce profound antitumor effects by activating tumor-specific T cells. ..
  40. doi request reprint The importance of evaluation of DNA amplificability in KRAS mutation testing with dideoxy sequencing using formalin-fixed and paraffin-embedded colorectal cancer tissues
    Naoko Okayama
    Division of Laboratory, Yamaguchi University Hospital, Ube, Yamaguchi, Japan
    Jpn J Clin Oncol 41:165-71. 2011
    ..We evaluated DNA amplificability to achieve a 100% success rate in KRAS mutation testing with dideoxy sequencing using formalin-fixed and paraffin-embedded colorectal cancer tissue samples obtained from a recent clinical trial...