Hiroshi Yamada

Summary

Affiliation: University of Shizuoka
Country: Japan

Publications

  1. ncbi request reprint Gargling with tea catechin extracts for the prevention of influenza infection in elderly nursing home residents: a prospective clinical study
    Hiroshi Yamada
    Division of Drug Evaluation and Informatics, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan
    J Altern Complement Med 12:669-72. 2006
  2. ncbi request reprint A randomized clinical study of tea catechin inhalation effects on methicillin-resistant Staphylococcus aureus in disabled elderly patients
    Hiroshi Yamada
    Division of Drug Evaluation and Informatics, University of Shizuoka, 52 1 Yada, Suruga ku, Shizuoka 422 8526, Japan
    J Am Med Dir Assoc 7:79-83. 2006
  3. ncbi request reprint An artifact derived from a pseudogene led to the discovery of microRNA binding site polymorphism in the 3'-untranslated region of the human dihydrofolate reductase gene
    Hideki Hayashi
    Department of Clinical Pharmacology and Genetics, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka
    Drug Metab Pharmacokinet 27:263-7. 2012
  4. ncbi request reprint A single nucleotide polymorphism of reduced folate carrier 1 predicts methotrexate efficacy in Japanese patients with rheumatoid arthritis
    Hideki Hayashi
    Department of Clinical Pharmacology and Genetics, School of Pharmaceutical Sciences, University of Shizuoka, and Department of Rheumatology, Shizuoka Kousei Hospital, Shizuoka, Japan
    Drug Metab Pharmacokinet 28:164-8. 2013
  5. doi request reprint Reduced folate carrier 1 gene expression levels are correlated with methotrexate efficacy in Japanese patients with rheumatoid arthritis
    Yui Tazoe
    Department of Clinical Pharmacology and Genetics, School of Pharmaceutical Sciences, University of Shizuoka, Suruga ku, Shizuoka, Japan
    Drug Metab Pharmacokinet 30:227-30. 2015
  6. pmc Effects of green tea consumption on cognitive dysfunction in an elderly population: a randomized placebo-controlled study
    Kazuki Ide
    Department of Drug Evaluation and Informatics, Graduate School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, Suruga ku, Shizuoka, 422 8526, Japan
    Nutr J 15:49. 2016
  7. ncbi request reprint Dihydrofolate reductase gene intronic 19-bp deletion polymorphisms in a Japanese population
    Hideki Hayashi
    Department of Clinical Pharmacology and Genetics, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan
    Drug Metab Pharmacokinet 25:516-8. 2010
  8. pmc Age-related changes in the distributions of depressive symptom items in the general population: a cross-sectional study using the exponential distribution model
    Shinichiro Tomitaka
    Department of Mental Health, Panasonic Health Center, Tokyo, Japan Department of Drug Evaluation and Informatics, Graduate School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan
    Peerj 4:e1547. 2016
  9. pmc Effects of green tea catechins and theanine on preventing influenza infection among healthcare workers: a randomized controlled trial
    Keiji Matsumoto
    Department of Drug Evaluation and Informatics, Graduate School of Pharmaceutical Sciences, University of Shizuoka, Yada, Suruga ku, Shizuoka, Japan
    BMC Complement Altern Med 11:15. 2011
  10. pmc Reporting of adverse events related to dietary supplements to a public health center by medical staff: a survey of clinics and pharmacies
    Kazuki Ide
    Department of Drug Evaluation and Informatics, Graduate School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka
    Ther Clin Risk Manag 12:1403-10. 2016

Collaborators

  • Yuuichi Ukawa
  • Yutaka Ono
  • Hiroshi Watanabe
  • Keiji Matsumoto
  • Shizuo Yamada
  • Yukihiko Hara
  • Takashi Daimon
  • Yoshiyuki Kagawa
  • Toshimasa Toyo'oka
  • Naoko Igarashi
  • Masashi Goto
  • Satomi Onoue
  • Keiko Unno
  • K Umegaki
  • Kiyoshi Harada
  • M Takahata
  • Naoyuki Kurokawa
  • Kazuki Ide
  • Yohei Kawasaki
  • Hideki Hayashi
  • Kunihiko Itoh
  • Yui Tazoe
  • Seiji Tsuboi
  • Kazuyuki Inoue
  • Taiji Matsuyama
  • Kazuhiro Kosuge
  • Shinichiro Tomitaka
  • Daiki Tsuji
  • Kumi Matsushita
  • Mijong Park
  • Masato Horino
  • Maiko Akutagawa
  • Masakazu Fujiwara
  • Daichi Narushima
  • Kunio Yui
  • Toshiaki A Furukawa
  • Mamoru Kitagawa
  • Yuko M Sagesaka
  • Norikata Takuma
  • Junpei Nakase
  • Keita Hirai
  • Yoshinari Yokoyama
  • Mariko Morishita
  • Chihiro Fujimaki
  • Teppei Akiyama
  • Shinya Uchida
  • Masafumi Motohashi
  • Toshinori Nishikimi
  • Hiroshi Miyazaki
  • Shoji Takamatsu
  • Etsuo Miyaoka
  • Nasoyuki Tanuma
  • Shohei Harada
  • Naohiko Masaki
  • Tsuyoshi Chiba
  • Kotaro Yamakado
  • Marika Noguchi
  • Asanao Shimokawa
  • Tadashi Sugiyama
  • Masako Waki
  • Yuma Buno
  • Masayuki Kaji
  • Tsunehiro Yokochi
  • Mizuki Matsumoto
  • Katsuki Mizuno
  • Kazuko Fujimoto
  • Tomone Shioura
  • Nobuko Kawakami
  • Emi Shiosaki
  • Hidefumi Yoshida
  • Mitsuyoshi Nakashima
  • Kang Kim
  • Yuka Hagiwara
  • Yoichi Sameshima
  • Kei Nojiri
  • Kenichiro Todoroki
  • Miho Tomatsuri
  • Kiichiro Toyoizumi
  • Yuto Yamada
  • Nobuhiko Nomura
  • Noriko Wakamiya
  • Miki Ito
  • Teruhisa Arai
  • Motohiro Ohshima
  • Chihiro Fujimaki-Katoh
  • Shinya Kaji
  • Yuko Okada
  • Takahiro Goto
  • Toshiro Kitagawa
  • Toshiko Imai

Detail Information

Publications41

  1. ncbi request reprint Gargling with tea catechin extracts for the prevention of influenza infection in elderly nursing home residents: a prospective clinical study
    Hiroshi Yamada
    Division of Drug Evaluation and Informatics, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan
    J Altern Complement Med 12:669-72. 2006
    ..To evaluate the effects of gargling tea catechin extracts on the prevention of influenza infection in elderly nursing home residents...
  2. ncbi request reprint A randomized clinical study of tea catechin inhalation effects on methicillin-resistant Staphylococcus aureus in disabled elderly patients
    Hiroshi Yamada
    Division of Drug Evaluation and Informatics, University of Shizuoka, 52 1 Yada, Suruga ku, Shizuoka 422 8526, Japan
    J Am Med Dir Assoc 7:79-83. 2006
    ..To evaluate the effects of tea catechin inhalation on methicillin-resistant Staphylococcus aureus (MRSA) in disabled elderly patients...
  3. ncbi request reprint An artifact derived from a pseudogene led to the discovery of microRNA binding site polymorphism in the 3'-untranslated region of the human dihydrofolate reductase gene
    Hideki Hayashi
    Department of Clinical Pharmacology and Genetics, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka
    Drug Metab Pharmacokinet 27:263-7. 2012
    ..This study is a reinvestigation of a newly discovered genetic polymorphism...
  4. ncbi request reprint A single nucleotide polymorphism of reduced folate carrier 1 predicts methotrexate efficacy in Japanese patients with rheumatoid arthritis
    Hideki Hayashi
    Department of Clinical Pharmacology and Genetics, School of Pharmaceutical Sciences, University of Shizuoka, and Department of Rheumatology, Shizuoka Kousei Hospital, Shizuoka, Japan
    Drug Metab Pharmacokinet 28:164-8. 2013
    ..The results of this study suggest that the RFC1 G80A polymorphism may be a useful marker for predicting MTX efficacy in Japanese patients with RA...
  5. doi request reprint Reduced folate carrier 1 gene expression levels are correlated with methotrexate efficacy in Japanese patients with rheumatoid arthritis
    Yui Tazoe
    Department of Clinical Pharmacology and Genetics, School of Pharmaceutical Sciences, University of Shizuoka, Suruga ku, Shizuoka, Japan
    Drug Metab Pharmacokinet 30:227-30. 2015
    ..Increased RFC1 expression may increase MTX uptake by immune cells, such as lymphocytes, and as a result, RA disease activity would be reduced. ..
  6. pmc Effects of green tea consumption on cognitive dysfunction in an elderly population: a randomized placebo-controlled study
    Kazuki Ide
    Department of Drug Evaluation and Informatics, Graduate School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, Suruga ku, Shizuoka, 422 8526, Japan
    Nutr J 15:49. 2016
    ..Green tea is a beverage with potential effects on cognitive dysfunction, as indicated by results of experimental studies. However, its effects in humans, especially at real-world (typical) consumption levels, are unclear...
  7. ncbi request reprint Dihydrofolate reductase gene intronic 19-bp deletion polymorphisms in a Japanese population
    Hideki Hayashi
    Department of Clinical Pharmacology and Genetics, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan
    Drug Metab Pharmacokinet 25:516-8. 2010
    ....
  8. pmc Age-related changes in the distributions of depressive symptom items in the general population: a cross-sectional study using the exponential distribution model
    Shinichiro Tomitaka
    Department of Mental Health, Panasonic Health Center, Tokyo, Japan Department of Drug Evaluation and Informatics, Graduate School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan
    Peerj 4:e1547. 2016
    ..The differences in the scoring method may contribute to the different age-related patterns across the adult lifespan. ..
  9. pmc Effects of green tea catechins and theanine on preventing influenza infection among healthcare workers: a randomized controlled trial
    Keiji Matsumoto
    Department of Drug Evaluation and Informatics, Graduate School of Pharmaceutical Sciences, University of Shizuoka, Yada, Suruga ku, Shizuoka, Japan
    BMC Complement Altern Med 11:15. 2011
    ..This study was conducted to determine whether taking green tea catechins and theanine can clinically prevent influenza infection...
  10. pmc Reporting of adverse events related to dietary supplements to a public health center by medical staff: a survey of clinics and pharmacies
    Kazuki Ide
    Department of Drug Evaluation and Informatics, Graduate School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka
    Ther Clin Risk Manag 12:1403-10. 2016
    ..To date, however, reporting has been limited. The aim of this study was to address this deficiency by exploring the routine reporting practices of the medical staff employed at clinics or pharmacies in Japan...
  11. pmc Green tea consumption affects cognitive dysfunction in the elderly: a pilot study
    Kazuki Ide
    Department of Drug Evaluation and Informatics, Graduate School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, Suruga ku, Shizuoka 422 8526, Japan
    Nutrients 6:4032-42. 2014
    ....
  12. ncbi request reprint Effects of Green Tea Gargling on the Prevention of Influenza Infection: An Analysis Using Bayesian Approaches
    Kazuki Ide
    Department of Drug Evaluation and Informatics, Graduate School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan
    J Altern Complement Med . 2016
    ..The aim of this study is to analyze the data obtained from a randomized trial on the prevention of influenza by gargling with green tea, which gave nonsignificant results based on frequentist approaches, by using Bayesian approaches...
  13. doi request reprint Green tea consumption is inversely associated with the incidence of influenza infection among schoolchildren in a tea plantation area of Japan
    Mijong Park
    Department of Drug Evaluation and Informatics, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan
    J Nutr 141:1862-70. 2011
    ..30-0.94); P = 0.03], respectively. However, there was no significant association with the consumption of >5 cups/d. Our findings thus suggest that the consumption of 1-5 cups/d of green tea may prevent influenza infection in children...
  14. pmc Boundary curves of individual items in the distribution of total depressive symptom scores approximate an exponential pattern in a general population
    Shinichiro Tomitaka
    Department of Mental Health, Panasonic Health Center, Tokyo, Japan Department of Drug Evaluation and Informatics, Graduate School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan
    Peerj 4:e2566. 2016
    ..To verify this hypothesis, we investigated the boundary curves of the distribution of total depressive symptom scores in a general population...
  15. pmc Effect of gargling with tea and ingredients of tea on the prevention of influenza infection: a meta-analysis
    Kazuki Ide
    Department of Drug Evaluation and Informatics, Graduate School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, Suruga ku, Shizuoka, 422 8526, Japan
    BMC Public Health 16:396. 2016
    ..Although several clinical studies have investigated the use of tea or its ingredients to prevent influenza infections, the effect of gargling these substances has remained uncertain...
  16. pmc Regional differences in hepatitis C treatment with peginterferon and ribavirin in Japan: a retrospective cohort study
    Kazuki Ide
    Department of Drug Evaluation and Informatics, Graduate School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan
    Drug Des Devel Ther 10:1217-23. 2016
    ....
  17. pmc Methods for estimating causal relationships of adverse events with dietary supplements
    Kazuki Ide
    Department of Drug Evaluation and Informatics, Graduate School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan
    BMJ Open 5:e009038. 2015
    ..The aim of this study was to develop optimised methods to evaluate the causal relationships between adverse events and dietary supplements, and to test these methods using case reports...
  18. doi request reprint Lymphocyte vitamin C levels as potential biomarker for progression of Parkinson's disease
    Kazuki Ide
    Department of Drug Evaluation and Informatics, Graduate School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan
    Nutrition 31:406-8. 2015
    ..The aim of this study was to investigate the association between lymphocyte and plasma vitamin C levels in various stages of Parkinson's disease (PD)...
  19. pmc Effects of green tea gargling on the prevention of influenza infection in high school students: a randomized controlled study
    Kazuki Ide
    Department of Drug Evaluation and Informatics, Graduate School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan
    PLoS ONE 9:e96373. 2014
    ..As a non-pharmaceutical intervention against infection, gargling is also commonly performed in Asian countries but has not yet been extensively studied...
  20. doi request reprint Simultaneous microdetermination of bosentan, ambrisentan, sildenafil, and tadalafil in plasma using liquid chromatography/tandem mass spectrometry for pediatric patients with pulmonary arterial hypertension
    Yoshinari Yokoyama
    Department of Clinical Pharmacology and Genetics, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan
    J Pharm Biomed Anal 89:227-32. 2014
    ..These results indicate that this method is suitable for assessing the risk/benefit of combination therapy in the pediatric population and useful for therapeutic drug monitoring for PAH treatment. ..
  21. doi request reprint Reduced endogenous urinary total antioxidant power and its relation of plasma antioxidant activity of superoxide dismutase in individuals with autism spectrum disorder
    Kunio Yui
    Department of Pediatrics, Dokkyo Medical University, 880 Kitakobayashi, Mibu 321 0293, Tochigi, Japan Department of Drug Evaluation and Informatics, School of Pharmaceutical Science, University of Shizuoka, Shizuoka 422 8526, Japan Electronic address
    Int J Dev Neurosci . 2016
    ..The endogenous antioxidant capacity may be deficient without altered urinary HEL and 8-OHdG levels in individuals with ASD. The plasma SOD levels may be related to reduced endogenous antioxidant capacity...
  22. pmc A Pharmacovigilance Approach for Post-Marketing in Japan Using the Japanese Adverse Drug Event Report (JADER) Database and Association Analysis
    Masakazu Fujiwara
    Department of Drug Evaluation and Informatics, Graduate School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan
    PLoS ONE 11:e0154425. 2016
    ..g. gender) has not been proposed...
  23. pmc Adverse events associated with incretin-based drugs in Japanese spontaneous reports: a mixed effects logistic regression model
    Daichi Narushima
    Drug Evaluation and Informatics, University of Shizuoka, Shizuoka, Shizuoka, Japan
    Peerj 4:e1753. 2016
    ..Furthermore, we applied this approach to analyze ADEs of incretin-based drugs such as DPP-4 inhibitors and GLP-1 receptor agonists, which are widely used to treat type 2 diabetes...
  24. doi request reprint Possible Gender Difference in Anti-stress Effect of β-Cryptoxanthin
    Keiko Unno
    Department of Neurophysiology, School of Pharmaceutical Sciences, University of Shizuoka
    Yakugaku Zasshi 136:1255-62. 2016
    ..In the β-CRX-group, the increase of post-practice sAA was suppressed in females. These results suggested that β-CRX has an anti-stress effect, at least, in females. ..
  25. doi request reprint A Bayesian equivalency test for two independent binomial proportions
    Yohei Kawasaki
    a Department of Drug Evaluation and Informatics, School of Pharmaceutical Sciences, University of Shizuoka, Suruga ku, Shizuoka, Japan
    J Biopharm Stat 26:781-9. 2016
    ..Moreover, we apply this index to the results of actual clinical trials to demonstrate the utility of the index. ..
  26. doi request reprint Reactive oxygen species assay-based risk assessment of drug-induced phototoxicity: classification criteria and application to drug candidates
    Satomi Onoue
    Department of Pharmacokinetics and Pharmacodynamics and Global Center of Excellence COE Program, School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, Shizuoka 422 8526, Japan
    J Pharm Biomed Anal 47:967-72. 2008
    ..These results verify the usefulness of the ROS assay for understanding the phototoxicity risk of pharmaceutical substances, and the ROS assay can be used for screening purposes in the drug discovery stage...
  27. ncbi request reprint Assessing nonlinearity in compartment models via the relative curvature measure
    Takashi Daimon
    Division of Drug Evaluation and Informatics, Graduate School of Pharmaceutical Sciences, University of Shizuoka, 52 1, Yada, Suruga ku, Shizuoka, 422 8526, Japan
    J Pharmacokinet Pharmacodyn 34:207-27. 2007
    ..The results showed that the relative curvature measure with the variance function was not affected by heteroscedastic blood drug concentration data and could be utilized for the assessment of the nonlinearity in compartment models...
  28. doi request reprint Plasma total homocysteine level and methylenetetrahydrofolate reductase 677C>T genetic polymorphism in Japanese patients with rheumatoid arthritis
    Chihiro Fujimaki
    Department of Clinical Pharmacology and Genetics, School of Pharmaceutical Sciences, University of Shizuoka, Suruga ku, Shizuoka, Japan
    Biomarkers 14:49-54. 2009
    ..Therefore, we conclude that homocysteine might affect the inflammatory status of patients, and the MTHFR 677C>T SNP could be a predictive factor of hyperhomocysteinemia in patients with RA...
  29. ncbi request reprint Effects of Ginkgo biloba extract on pharmacokinetics and pharmacodynamics of tolbutamide and midazolam in healthy volunteers
    Shinya Uchida
    Department of Pharmacokinetics, Center of Excellence Program in the 21st Century, School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, Suruga ku, Shizuoka, 422 8526, Japan
    J Clin Pharmacol 46:1290-8. 2006
    ..Thus, it is suggested that the combination of GBE and drugs should be cautious in terms of the potential interactions, especially in elderly patients or patients treated with drugs exerting relatively narrow therapeutic windows...
  30. ncbi request reprint Employing dmft score as a risk predictor for caries development in the permanent teeth in Japanese primary school girls
    Masafumi Motohashi
    Department of Oral Health Sciences, Nihon University School of Dentistry, Tokyo, Japan
    J Oral Sci 48:233-7. 2006
    ..In both cohorts, the risk ratio for permanent teeth caries was significant for many cut-off levels of dmft. The results indicated that the dmft score is a useful predictor of the permanent teeth caries in Japanese primary school girls...
  31. ncbi request reprint Lymphocyte and plasma vitamin C levels in type 2 diabetic patients with and without diabetes complications
    Hiroshi Yamada
    General Clinical Research Center, Hamamatsu University School of Medicine, Japan
    Diabetes Care 27:2491-2. 2004
  32. ncbi request reprint [In vitro and in vivo antibacterial activities of pazufloxacin mesilate, a new injectable quinolone]
    Nobuhiko Nomura
    Jpn J Antibiot 55:412-39. 2002
    ..6) Intravenous administration of PZFX with high plasma concentration just after administration, showed more excellent therapeutic effect against the rat intraperitoneal infection, than p.o. and s.c. administration...
  33. ncbi request reprint Influence of stability on range of motion after cruciate-retaining TKA
    Kotaro Yamakado
    Department of Orthopaedic Surgery, School of Medicine, Kanazawa University, 13 1, Takara machi, Kanazawa, 920 8641, Japan
    Arch Orthop Trauma Surg 123:1-4. 2003
    ..A loosely balanced total knee arthroplasty (TKA) is reported to produce a good postoperative range of motion (ROM), but too much laxity is thought to be the cause of persistent pain and worsened functionality...
  34. ncbi request reprint Pharmacokinetic and pharmacodynamic interactions between simvastatin and diltiazem in patients with hypercholesterolemia and hypertension
    Hiroshi Watanabe
    Department of Clinical Pharmacology and Therapeutics, Hamamatsu University School of Medicine, 1 20 1 Handayama, Hamamatsu 431 3192, Japan
    Life Sci 76:281-92. 2004
    ....
  35. ncbi request reprint Tea polyphenols in preventing cardiovascular diseases
    Hiroshi Yamada
    Cardiovasc Res 73:439-40. 2007
  36. ncbi request reprint New electronic device for monitoring medication compliance
    Hiroshi Yamada
    Am J Health Syst Pharm 60:1910-1. 2003
  37. ncbi request reprint [The effects of inhaled carbon monoxide on lung injury in rats caused by lipopolysaccharide]
    Hiroshi Miyazaki
    Department of Anesthesia, Chigasaki Municipal Hospital, Chigasaki 253 0042
    Masui 52:363-9. 2003
    ..Carbon monoxide (CO) has long been considered a toxic substance. Recent studies have revealed that CO may play an important role in intercellular signaling. We hypothesized that CO modulates the inflammatory mechanisms...
  38. ncbi request reprint [In vitro interaction of tazobactam/piperacillin combined with aminoglycosides against Pseudomonas aeruginosa, Klebsiella pneumoniae, Escherichia coli AND Staphylococcus aureus]
    Hiroshi Yamada
    Research Laboratories, Toyama Chemical Co, Ltd, 4 1, Shimookui 2 chome, Toyama 930 8508, Japan
    Jpn J Antibiot 55:61-6. 2002
    ..In conclusion, these results suggest that the combination therapies of TAZ/PIPC with aminoglycosides are useful for the clinical treatment of sepsis caused by above four species...
  39. ncbi request reprint [A case of multiple lung metastases and cervical lymph node metastasis of renal cell carcinoma failing to respond to interferon-alpha (IFN-alpha) but markedly responding to interleukin-2 (IL-2)]
    Toshinori Nishikimi
    Department of Urology, Nagoya Daini Red Cross Hospital
    Nihon Hinyokika Gakkai Zasshi 95:54-8. 2004
    ..Therefore, the tumor response to IL-2 was suggested to depend on NK activity and LAK activity...
  40. ncbi request reprint [In order to perform clinical trials efficiently in Japan--important issues in medical institutions raised by the GCP on-site review]
    Teppei Akiyama
    The Office of Conformity Audit, Pharmaceuticals and Medical Devices Agency
    Nihon Kokyuki Gakkai Zasshi 44:541-9. 2006
    ..We hope that our findings at investigational sites will promote the protection of human rights and improve the quality of clinical trials in Japan...
  41. pmc Evaluation of T-3811ME (BMS-284756), a new des-F(6)-quinolone, for treatment of meningitis caused by penicillin-resistant Streptococcus pneumoniae in rabbits
    Masahiro Takahata
    Research Laboratories, Toyama Chemical Co, Ltd, Toyama, Japan
    Antimicrob Agents Chemother 46:1760-5. 2002
    ..T-3811ME (BMS-284756) may be expected to be evaluated for the management of meningitis caused by highly penicillin-resistant pneumococci...