Tomoaki Tomiya

Summary

Affiliation: University of Tokyo
Country: Japan

Publications

  1. pmc The mitogenic activity of hepatocyte growth factor on rat hepatocytes is dependent upon endogenous transforming growth factor-alpha
    T Tomiya
    First Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    Am J Pathol 157:1693-701. 2000
  2. ncbi request reprint Significance of branched chain amino acids as possible stimulators of hepatocyte growth factor
    Tomoaki Tomiya
    Department of Gastroenterology, University of Tokyo, Tokyo, Japan
    Biochem Biophys Res Commun 313:411-6. 2004
  3. ncbi request reprint Treatment with leucine stimulates the production of hepatocyte growth factor in vivo
    Tomoaki Tomiya
    Department of Gastroenterology, University of Tokyo, Tokyo, Japan
    Biochem Biophys Res Commun 322:772-7. 2004
  4. ncbi request reprint Leucine stimulates HGF production by hepatic stellate cells through mTOR pathway
    Tomoaki Tomiya
    Department of Gastroenterology, University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo 113 8655, Japan
    Biochem Biophys Res Commun 358:176-80. 2007
  5. ncbi request reprint Leucine stimulates the secretion of hepatocyte growth factor by hepatic stellate cells
    Tomoaki Tomiya
    Department of Gastroenterology, University of Tokyo, Tokyo, Japan
    Biochem Biophys Res Commun 297:1108-11. 2002
  6. ncbi request reprint Involvement of Rho/Rho kinase pathway in regulation of apoptosis in rat hepatic stellate cells
    Hitoshi Ikeda
    Dept of Gastroenterology, Univ of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Am J Physiol Gastrointest Liver Physiol 285:G880-6. 2003
  7. ncbi request reprint Sphingosine 1-phosphate enhances portal pressure in isolated perfused liver via S1P2 with Rho activation
    Hitoshi Ikeda
    Department of Gastroenterology, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Biochem Biophys Res Commun 320:754-9. 2004
  8. ncbi request reprint Stimulation by glutamine and proline of HGF production in hepatic stellate cells
    Takako Nishikawa
    Department of Gastroenterology, Faculty of Medicine, University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo 113 8655, Japan
    Biochem Biophys Res Commun 363:978-82. 2007
  9. ncbi request reprint Ischemic preconditioning in liver pathophysiology
    Masahiro Arai
    Department of Gastroenterology, Toshiba General Hospital, Shinagawa ku, Tokyo, Japan
    J Gastroenterol Hepatol 22:S65-7. 2007
  10. pmc Sphingosine 1-phosphate regulates regeneration and fibrosis after liver injury via sphingosine 1-phosphate receptor 2
    Hitoshi Ikeda
    Department of Clinical Laboratory Medicine, Graduate School of Medicine, The University of Tokyo, Bunkyo ku, Tokyo, Japan
    J Lipid Res 50:556-64. 2009

Collaborators

Detail Information

Publications36

  1. pmc The mitogenic activity of hepatocyte growth factor on rat hepatocytes is dependent upon endogenous transforming growth factor-alpha
    T Tomiya
    First Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    Am J Pathol 157:1693-701. 2000
    ..Our results suggest that HGF stimulates TGF-alpha production in rat hepatocytes, and that the mitogenic activity of HGF depends on endogenous TGF-alpha activity...
  2. ncbi request reprint Significance of branched chain amino acids as possible stimulators of hepatocyte growth factor
    Tomoaki Tomiya
    Department of Gastroenterology, University of Tokyo, Tokyo, Japan
    Biochem Biophys Res Commun 313:411-6. 2004
    ..A potential application of HGF for several types of diseases has been postulated. Here, we describe the potential of BCAAs as a therapeutic agent that acts through the induction of HGF production in the liver...
  3. ncbi request reprint Treatment with leucine stimulates the production of hepatocyte growth factor in vivo
    Tomoaki Tomiya
    Department of Gastroenterology, University of Tokyo, Tokyo, Japan
    Biochem Biophys Res Commun 322:772-7. 2004
    ..Taken together with our previous report showing that leucine stimulates HGF production by hepatic stellate cells in culture, leucine, among BCAAs, may induce an increase in HGF production by the liver in vivo...
  4. ncbi request reprint Leucine stimulates HGF production by hepatic stellate cells through mTOR pathway
    Tomoaki Tomiya
    Department of Gastroenterology, University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo 113 8655, Japan
    Biochem Biophys Res Commun 358:176-80. 2007
    ..An mTOR-dependent signaling pathway mediates the stimulatory effect of leucine on the production of HGF by hepatic stellate cells...
  5. ncbi request reprint Leucine stimulates the secretion of hepatocyte growth factor by hepatic stellate cells
    Tomoaki Tomiya
    Department of Gastroenterology, University of Tokyo, Tokyo, Japan
    Biochem Biophys Res Commun 297:1108-11. 2002
    ..These results demonstrate that, among BCAAs, leucine stimulates the secretion of HGF by cultured hepatic stellate cells...
  6. ncbi request reprint Involvement of Rho/Rho kinase pathway in regulation of apoptosis in rat hepatic stellate cells
    Hitoshi Ikeda
    Dept of Gastroenterology, Univ of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Am J Physiol Gastrointest Liver Physiol 285:G880-6. 2003
    ..Inhibition of the Rho/Rho kinase pathway did not affect p53, Bcl-2, or Bax levels in HSCs. Thus we concluded that the Rho/Rho kinase pathway may play a role in the regulation of HSC survival...
  7. ncbi request reprint Sphingosine 1-phosphate enhances portal pressure in isolated perfused liver via S1P2 with Rho activation
    Hitoshi Ikeda
    Department of Gastroenterology, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Biochem Biophys Res Commun 320:754-9. 2004
    ..2 microM, S1P might readily regulate portal vascular tone in physiological and pathological status. The antagonist for S1P2 merits consideration for treatment of portal hypertension...
  8. ncbi request reprint Stimulation by glutamine and proline of HGF production in hepatic stellate cells
    Takako Nishikawa
    Department of Gastroenterology, Faculty of Medicine, University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo 113 8655, Japan
    Biochem Biophys Res Commun 363:978-82. 2007
    ..Glutamine and proline may have the potential to stimulate HGF production but the mechanism underlying this stimulation seems not to be through the mTOR-dependent signaling pathway...
  9. ncbi request reprint Ischemic preconditioning in liver pathophysiology
    Masahiro Arai
    Department of Gastroenterology, Toshiba General Hospital, Shinagawa ku, Tokyo, Japan
    J Gastroenterol Hepatol 22:S65-7. 2007
    ....
  10. pmc Sphingosine 1-phosphate regulates regeneration and fibrosis after liver injury via sphingosine 1-phosphate receptor 2
    Hitoshi Ikeda
    Department of Clinical Laboratory Medicine, Graduate School of Medicine, The University of Tokyo, Bunkyo ku, Tokyo, Japan
    J Lipid Res 50:556-64. 2009
    ..Thus, S1P plays a significant role in regeneration and fibrosis after liver injury via S1P(2)...
  11. doi request reprint Autotaxin as a novel serum marker of liver fibrosis
    Hayato Nakagawa
    Department of Clinical Laboratory Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Clin Chim Acta 412:1201-6. 2011
    ..Serum ATX enzymatic activity reportedly increases in parallel with liver fibrosis and exhibits a gender difference...
  12. doi request reprint Plasma concentration of bioactive lipid mediator sphingosine 1-phosphate is reduced in patients with chronic hepatitis C
    Hitoshi Ikeda
    Department of Clinical Laboratory Medicine, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Clin Chim Acta 411:765-70. 2010
    ..Because our previous evidence suggests that S1P is involved in liver pathophysiology, we examined plasma S1P concentration in chronic hepatitis C patients...
  13. pmc Induction of ischemic tolerance in rat liver via reduced nicotinamide adenine dinucleotide phosphate oxidase in Kupffer cells
    Kazuaki Tejima
    Department of Gastroenterology, University of Tokyo, and Toshiba General Hospital, 6 3 22 Higashiooi, Shinagawa ku, Tokyo 140 8522, Japan
    World J Gastroenterol 13:5071-8. 2007
    ..To elucidate the mechanisms of hepatocyte preconditioning by H2O2 to better understand the pathophysiology of ischemic preconditioning...
  14. ncbi request reprint p53 May positively regulate hepatocyte proliferation in rats
    Yukiko Inoue
    Department of Gastroenterology, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    Hepatology 36:336-44. 2002
    ..Considering previous findings indicating the importance of endogenous TGF-alpha for the proliferation of hepatocytes stimulated by HGF, TGF-alpha might play a role in HGF-p53 mediated hepatocyte proliferation...
  15. ncbi request reprint Plasma lysophosphatidic acid level and serum autotaxin activity are increased in liver injury in rats in relation to its severity
    Naoko Watanabe
    Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Tokyo 113 8655, Japan
    Life Sci 81:1009-15. 2007
    ..Whether increased ATX and LPA in the blood in liver injury is simply a result or also a cause of the injury should be further clarified...
  16. pmc Induction of p53-dependent p21 limits proliferative activity of rat hepatocytes in the presence of hepatocyte growth factor
    Yukiko Inoue
    Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    PLoS ONE 8:e78346. 2013
    ..p53, a transcription factor, suppresses the cell proliferation by expressing p21(WAF1/CIP1) in various tissues...
  17. ncbi request reprint Effect of rapamycin on hepatocyte function and proliferation induced by growth factors
    Tomoaki Tomiya
    Department of Gastroenterology, Fuculty of Medicine, University of Tokyo, Tokyo, Japan
    Chemotherapy 53:59-69. 2007
    ..The effect of rapamycin on proliferation and cellular function was studied in hepatocytes stimulated by hepatocyte growth factor (HGF) or transforming growth factor-alpha (TGFalpha)...
  18. ncbi request reprint The herbal medicine inchin-ko-to (TJ-135) induces apoptosis in cultured rat hepatic stellate cells
    Hitoshi Ikeda
    Department of Gastroenterology, University of Tokyo, Bunkyo ku, Japan
    Life Sci 78:2226-33. 2006
    ..Thus, the induction of HSC apoptosis could be the mechanism how TJ-135 works on the resolution of hepatic fibrosis. Our current data may shed light on the novel effect of the herbal remedy...
  19. ncbi request reprint Functional diversity between Rho-kinase- and MLCK-mediated cytoskeletal actions in a myofibroblast-like hepatic stellate cell line
    Mikio Yanase
    Department of Gastroenterology, Faculty of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, 113 0033, Tokyo, Japan
    Biochem Biophys Res Commun 305:223-8. 2003
    ..These findings suggest that the actomyosin-based cytoskeletal actions can be functionally diverse depending on the Rho-kinase-mediated pathway and the MLCK-mediated pathway...
  20. ncbi request reprint Rho-kinase inhibitor prevents hepatocyte damage in acute liver injury induced by carbon tetrachloride in rats
    Hitoshi Ikeda
    Dept of Laboratory Medicine, The Univ of Tokyo, 7 3 1 Hongo, Tokyo 113 8655, Japan
    Am J Physiol Gastrointest Liver Physiol 293:G911-7. 2007
    ....
  21. doi request reprint Antagonism of sphingosine 1-phosphate receptor 2 causes a selective reduction of portal vein pressure in bile duct-ligated rodents
    Yuko Kageyama
    Department of Clinical Laboratory Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Hepatology 56:1427-38. 2012
    ..Furthermore, the increase of Rho kinase activity in bile duct-ligated livers was observed as early as 7 days after the operation in wildtype mice, but was less in S1P 2-/- mice...
  22. ncbi request reprint Antiproliferative property of sphingosine 1-phosphate in rat hepatocytes involves activation of Rho via Edg-5
    Hitoshi Ikeda
    Department of Gastroenterology, University of Tokyo, Japan
    Gastroenterology 124:459-69. 2003
    ..Because the major part of injected S1P was distributed into the liver in mice, we wondered whether the liver would be one of its targets. The effects of S1P on hepatocytes, the major constituent cells in the liver, were examined...
  23. ncbi request reprint Ischemic preconditioning protects hepatocytes via reactive oxygen species derived from Kupffer cells in rats
    Kazuaki Tejima
    Department of Gastroenterology, University of Tokyo, Tokyo, Japan
    Gastroenterology 127:1488-96. 2004
    ..We aimed to determine whether ischemic preconditioning directly protects hepatocytes and to elucidate its mechanisms...
  24. ncbi request reprint Expression of α-taxilin in hepatocellular carcinoma correlates with growth activity and malignant potential of the tumor
    Natsuko Ohtomo
    Department of Gastroenterology, University of Tokyo, Bunkyo ku, Tokyo, Japan
    Int J Oncol 37:1417-23. 2010
    ..taxilin may be involved in cell proliferation of HCC, and its expression can be a marker of malignant potential of HCC...
  25. ncbi request reprint Expression of transforming growth factor-alpha and -beta in hepatic lobes after hemihepatic portal vein embolization
    Koji Kusaka
    Hepato Biliary Pancreatic Surgery Division, Department of Surgery, Graduate School of Medicine, University of Tokyo, 7 3 1, Hongo, Tokyo 113 8655, Japan
    Dig Dis Sci 51:1404-12. 2006
    ....
  26. doi request reprint Prediction of hepatocellular carcinoma development by plasma ADAMTS13 in chronic hepatitis B and C
    Hitoshi Ikeda
    Department of Clinical Laboratory Medicine, Graduate School of Medicine, The University of Tokyo, Hongo, Bunkyo ku, Tokyo, Japan
    Cancer Epidemiol Biomarkers Prev 20:2204-11. 2011
    ....
  27. doi request reprint Increased production of ADAMTS13 in hepatic stellate cells contributes to enhanced plasma ADAMTS13 activity in rat models of cholestasis and steatohepatitis
    Naoko Watanabe
    Department of Clinical Laboratory Medicine, The University of Tokyo, Tokyo 113 8655, Japan
    Thromb Haemost 102:389-96. 2009
    ....
  28. doi request reprint High ubiquitous mitochondrial creatine kinase expression in hepatocellular carcinoma denotes a poor prognosis with highly malignant potential
    Baasanjav Uranbileg
    Department of Clinical Laboratory Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Int J Cancer 134:2189-98. 2014
    ....
  29. ncbi request reprint Stabilization of RNA strands in protein synthesis by type I procollagen C-proteinase enhancer protein, a potential RNA-binding protein, in hepatic stellate cells
    Atsushi Matsui
    Department of Gastroentelorogy, University of Tokyo, Tokyo, Japan
    Biochem Biophys Res Commun 290:898-902. 2002
    ..PCPE may be involved in stabilization of RNA strands in noncollagenous protein synthesis as well as collagen synthesis...
  30. ncbi request reprint Both plasma lysophosphatidic acid and serum autotaxin levels are increased in chronic hepatitis C
    Naoko Watanabe
    Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    J Clin Gastroenterol 41:616-23. 2007
    ..Autotaxin (ATX), originally purified as an autocrine motility factor for melanoma cells, was revealed to be a key enzyme in LPA synthesis. We determined LPA and ATX levels in the blood of patients with liver disease...
  31. ncbi request reprint Hepatic stellate cell damage may lead to decreased plasma ADAMTS13 activity in rats
    Yukio Kume
    Department of Laboratory Medicine, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    FEBS Lett 581:1631-4. 2007
    ..Furthermore, plasma ADAMTS13 activity was also reduced in 70% hepatectomized rats, where HSC loss occurs. These results suggest that HSC may be involved in the regulation of plasma ADAMTS13 activity...
  32. doi request reprint Expression of α-taxilin in the murine gastrointestinal tract: potential implication in cell proliferation
    Yukimi Horii
    Department of Molecular and Cell Biology, Graduate School of Medicine, Dokkyo Medical University, 880 Kitakobayashi, Mibu cho, Tochigi, 321 0293, Japan
    Histochem Cell Biol 141:165-80. 2014
    ..These results suggest that expression of α-taxilin is regulated in parallel with cell proliferation in the murine gastrointestinal tract. ..
  33. ncbi request reprint Factors affecting liver regeneration after right portal vein embolization
    Koji Kusaka
    Department of Surgery, Hepato Biliary Pancreatic Surgery Division, Graduate School of Medicine, University of Tokyo, Japan
    Hepatogastroenterology 51:532-5. 2004
    ..The factors influencing the effect of portal vein embolization performed prior to hepatectomies are not clearly understood...
  34. ncbi request reprint Interaction of α-taxilin localized on intracellular components with the microtubule cytoskeleton
    Yukimi Horii
    Department of Molecular and Cell Biology, Graduate School of Medicine, Dokkyo Medical University, Tochigi, Japan
    Cell Struct Funct 37:111-26. 2012
    ....
  35. ncbi request reprint Impaired liver regeneration in acute liver failure: the significance of cross-communication of growth associated factors in liver regeneration
    Tomoaki Tomiya
    Department of Gastroenterology, University of Tokyo, Tokyo, Japan
    Hepatol Res 38:S29-33. 2008
    ....
  36. ncbi request reprint Adenovirus-mediated overexpression of follistatin enlarges intact liver of adult rats
    Kazuaki Takabe
    The Clayton Foundation Laboratories for Peptide Biology, The Salk Institute, La Jolla, CA 92037, USA
    Hepatology 38:1107-15. 2003
    ..In conclusion, our results suggest that activin plays a critical role in maintaining optimal liver size and implicates the endogenous activin system as a therapeutic target in the treatment of liver disease...