Masayuki Takeda

Summary

Affiliation: University of Yamanashi
Country: Japan

Publications

  1. ncbi request reprint The forefront for novel therapeutic agents based on the pathophysiology of lower urinary tract dysfunction: pathophysiology of voiding dysfunction and pharmacological therapy
    Masayuki Takeda
    Department of Urology, University of Yamanashi, Interdisciplinary Graduate School of Medicine and Engineering, Shimokato, Chuo City, Yamanashi 409 3898, Japan
    J Pharmacol Sci 112:121-7. 2010
  2. pmc Renal cell carcinoma treated with stereotactic radiotherapy with histological change confirmed on autopsy: a case report
    Hiroshi Onishi
    Department of Radiation Oncology, University of Yamanashi, 1110 Shimokato, 409 3898 Chuo city, Yamanashi, Japan
    BMC Res Notes 7:270. 2014
  3. doi request reprint Clinical efficacy and safety of imidafenacin as add-on treatment for persistent overactive bladder symptoms despite α-blocker treatment in patients with BPH: the ADDITION study
    Masayuki Takeda
    Department of Urology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Shimokato Chuo city, Yamanashi, Japan Electronic address
    Urology 82:887-93. 2013
  4. doi request reprint Predictive factors for the effect of the α1-D/A adrenoceptor antagonist naftopidil on subjective and objective criteria in patients with neurogenic lower urinary tract dysfunction
    Masayuki Takeda
    Department of Urology, Interdisciplinary Graduate School of Medicine, University of Yamanashi, Yamanashi, Japan
    BJU Int 108:100-7. 2011
  5. pmc Reciprocal regulation between proinflammatory cytokine-induced inducible NO synthase (iNOS) and connexin43 in bladder smooth muscle cells
    Kai Li
    Department of Molecular Signaling, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Chuo, Yamanashi 409 3898, Japan
    J Biol Chem 286:41552-62. 2011
  6. doi request reprint Functional roles of TRPV1 channels in lower urinary tract irritated by acetic acid: in vivo evaluations of the sex difference in decerebrate unanesthetized mice
    Mitsuharu Yoshiyama
    Department of Urology, University of Yamanashi Interdisciplinary Graduate School of Medicine and Engineering, Chuo, Yamanashi, Japan
    Am J Physiol Renal Physiol 298:F1351-9. 2010
  7. pmc Connexin43 hemichannel-mediated regulation of connexin43
    Kai Li
    Department of Molecular Signaling, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Chuo, Yamanashi, Japan
    PLoS ONE 8:e58057. 2013
  8. ncbi request reprint Continuous, noninvasive monitoring of local microscopic inflammation using a genetically engineered cell-based biosensor
    Yiman Meng
    Department of Molecular Signaling, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Yamanashi, Japan and Organ Transplantation Unit, 1st Affiliated Hospital, China Medical University, Shenyang, China
    Lab Invest 85:1429-39. 2005
  9. ncbi request reprint Synergistic effects of PDGF-BB and cAMP-elevating agents on expression of connexin43 in mesangial cells
    Jian Yao
    Dept of Molecular Signaling, Interdisciplinary Graduate School of Medicine and Engineering, Univ of Yamanashi, Tamaho, Yamanashi 409 3898, Japan
    Am J Physiol Renal Physiol 290:F1083-93. 2006
  10. pmc Profiling of functional phosphodiesterase in mesangial cells using a CRE-SEAP-based reporting system
    Ying Zhu
    Department of Molecular Signaling, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Chuo, Yamanashi 409 3898, Japan
    Br J Pharmacol 148:833-44. 2006

Collaborators

Detail Information

Publications80

  1. ncbi request reprint The forefront for novel therapeutic agents based on the pathophysiology of lower urinary tract dysfunction: pathophysiology of voiding dysfunction and pharmacological therapy
    Masayuki Takeda
    Department of Urology, University of Yamanashi, Interdisciplinary Graduate School of Medicine and Engineering, Shimokato, Chuo City, Yamanashi 409 3898, Japan
    J Pharmacol Sci 112:121-7. 2010
    ..The former includes agonists for muscarinic receptors and cholinesterase inhibitor; and the latter includes alpha(1)-adrenoceptor antagonists, NO donors, benzodiazepines, baclofen, dantrolene, and boturinum toxin...
  2. pmc Renal cell carcinoma treated with stereotactic radiotherapy with histological change confirmed on autopsy: a case report
    Hiroshi Onishi
    Department of Radiation Oncology, University of Yamanashi, 1110 Shimokato, 409 3898 Chuo city, Yamanashi, Japan
    BMC Res Notes 7:270. 2014
    ..This is the first report we are aware of documenting late histological effects of stereotactic body radiation therapy on renal cell carcinoma and surrounding normal tissue...
  3. doi request reprint Clinical efficacy and safety of imidafenacin as add-on treatment for persistent overactive bladder symptoms despite α-blocker treatment in patients with BPH: the ADDITION study
    Masayuki Takeda
    Department of Urology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Shimokato Chuo city, Yamanashi, Japan Electronic address
    Urology 82:887-93. 2013
    ..To evaluate the effects of add-on treatment with an anticholinergic (imidafenacin) on persistent overactive bladder (OAB) symptoms despite α-blocker (tamsulosin) treatment in patients with benign prostatic hyperplasia (BPH)...
  4. doi request reprint Predictive factors for the effect of the α1-D/A adrenoceptor antagonist naftopidil on subjective and objective criteria in patients with neurogenic lower urinary tract dysfunction
    Masayuki Takeda
    Department of Urology, Interdisciplinary Graduate School of Medicine, University of Yamanashi, Yamanashi, Japan
    BJU Int 108:100-7. 2011
    ....
  5. pmc Reciprocal regulation between proinflammatory cytokine-induced inducible NO synthase (iNOS) and connexin43 in bladder smooth muscle cells
    Kai Li
    Department of Molecular Signaling, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Chuo, Yamanashi 409 3898, Japan
    J Biol Chem 286:41552-62. 2011
    ..Our findings may provide an important molecular mechanism for the symptoms of bladder infection. In addition, it may further our understanding of the roles of GJs in inflammatory diseases...
  6. doi request reprint Functional roles of TRPV1 channels in lower urinary tract irritated by acetic acid: in vivo evaluations of the sex difference in decerebrate unanesthetized mice
    Mitsuharu Yoshiyama
    Department of Urology, University of Yamanashi Interdisciplinary Graduate School of Medicine and Engineering, Chuo, Yamanashi, Japan
    Am J Physiol Renal Physiol 298:F1351-9. 2010
    ....
  7. pmc Connexin43 hemichannel-mediated regulation of connexin43
    Kai Li
    Department of Molecular Signaling, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Chuo, Yamanashi, Japan
    PLoS ONE 8:e58057. 2013
    ..We, therefore, speculated an existence of the GJ channel-mediated self-regulation of GJs. Using a cell culture model in which nonjunctional connexin43 (Cx43) hemichannels were activated by cadmium (Cd(2+)), we tested this hypothesis...
  8. ncbi request reprint Continuous, noninvasive monitoring of local microscopic inflammation using a genetically engineered cell-based biosensor
    Yiman Meng
    Department of Molecular Signaling, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Yamanashi, Japan and Organ Transplantation Unit, 1st Affiliated Hospital, China Medical University, Shenyang, China
    Lab Invest 85:1429-39. 2005
    ..These results suggested that, without invasive procedures like tissue biopsies, continuous monitoring of microscopic inflammation is feasible in vivo via locally created, cell-based biosensors...
  9. ncbi request reprint Synergistic effects of PDGF-BB and cAMP-elevating agents on expression of connexin43 in mesangial cells
    Jian Yao
    Dept of Molecular Signaling, Interdisciplinary Graduate School of Medicine and Engineering, Univ of Yamanashi, Tamaho, Yamanashi 409 3898, Japan
    Am J Physiol Renal Physiol 290:F1083-93. 2006
    ..Regulation of GJIC could be an important mechanism via which PDGF modulates MC phenotypes...
  10. pmc Profiling of functional phosphodiesterase in mesangial cells using a CRE-SEAP-based reporting system
    Ying Zhu
    Department of Molecular Signaling, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Chuo, Yamanashi 409 3898, Japan
    Br J Pharmacol 148:833-44. 2006
    ..6. The present data elucidated that PDE3 and PDE4 play critical roles in the regulation of mesangial cell function. PDE3 and PDE4 were identified as the novel, antiapoptotic machinery that supports survival of mesangial cells...
  11. doi request reprint Suppression of NF-kappaB by cyclosporin a and tacrolimus (FK506) via induction of the C/EBP family: implication for unfolded protein response
    Shuqi Du
    Department of Molecular Signaling, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Yamanashi, Japan
    J Immunol 182:7201-11. 2009
    ..These results suggested that CsA and FK506 confer insensitiveness to TNF-alpha on resident cells through UPR-dependent induction of the C/EBP family members...
  12. doi request reprint Differential impact of lower urinary tract symptoms on generic and disease-specific quality of life in men and women
    Isao Araki
    Department of Urology, Faculty of Medicine, University of Yamanashi, Chuo, Japan
    Urol Int 81:60-5. 2008
    ..We investigated how generic and disease-specific measures differ in estimating the quality of life (QoL) impact of lower urinary tract symptoms (LUTS)...
  13. doi request reprint Functional roles of TRPV1 and TRPV4 in control of lower urinary tract activity: dual analysis of behavior and reflex during the micturition cycle
    Mitsuharu Yoshiyama
    Department of Urology, University of Yamanashi Graduate School of Medical Sciences, Chuo, Yamanashi, Japan
    Am J Physiol Renal Physiol 308:F1128-34. 2015
    ....
  14. doi request reprint Differential expression profile of cold (TRPA1) and cool (TRPM8) receptors in human urogenital organs
    Shuqi Du
    Department of Urology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Chuo, Yamanashi, Japan
    Urology 72:450-5. 2008
    ..In addition to TRPM8, a cool receptor, TRPA1 is recently recognized as a cold receptor. TRPA1 is also a candidate for mechanosensor and/or nociceptor...
  15. doi request reprint Nonsteroidal anti-inflammatory drug flufenamic acid is a potent activator of AMP-activated protein kinase
    Yuan Chi
    Departments of Molecular Signaling, University of Yamanashi, Yamanashi, Japan
    J Pharmacol Exp Ther 339:257-66. 2011
    ..Taken together, we conclude that FFA induces AMPK activation through the Ca(2+)-CaMKKβ pathway. Activation of AMPK is a presently unrecognized important mechanism underlying the pharmacological effects of FFA...
  16. doi request reprint The Clock mutant mouse is a novel experimental model for nocturia and nocturnal polyuria
    Tatsuya Ihara
    Department of Urology, Interdisciplinary Graduate School of Medicine, University of Yamanashi, Chuo, Yamanashi, Japan
    Neurourol Urodyn . 2016
    ..In the present study, we investigated the voiding behavior of Clock mutant (ClockΔ19/Δ19 ) mice in order to determine the effects of clock genes on NOC/NP...
  17. ncbi request reprint Overexpression of epithelial sodium channels in epithelium of human urinary bladder with outlet obstruction
    Isao Araki
    Department of Urology, University of Yamanashi, Interdisciplinary Graduate School of Medicine and Engineering, Tamaho, Yamanashi, Japan
    Urology 64:1255-60. 2004
    ..The increase of afferent activity is one of the possible mechanisms for this detrusor instability. The ENaC expressed in mammals has been implicated in various mechanosensory functions...
  18. doi request reprint Involvement of hypoxia-triggered endoplasmic reticulum stress in outlet obstruction-induced apoptosis in the urinary bladder
    Norifumi Sawada
    Department of Molecular Signaling, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Chuo, Yamanashi, Japan
    Lab Invest 88:553-63. 2008
    ..These results suggested that outlet obstruction caused ER stress via hypoxic stress in the bladder and that hypoxia-triggered ER stress may be involved in the induction of apoptosis in BOO...
  19. doi request reprint Solifenacin as add-on therapy for overactive bladder symptoms in men treated for lower urinary tract symptoms--ASSIST, randomized controlled study
    Osamu Yamaguchi
    Department of Urology, Fukushima Medical University School of Medicine, Fukushima, Japan
    Urology 78:126-33. 2011
    ..To assess the efficacy and safety of solifenacin add-on therapy to tamsulosin in lower urinary tract symptoms (LUTS) men with residual overactive bladder (OAB) symptoms despite tamsulosin monotherapy...
  20. doi request reprint Decreased expression of the epithelial Ca2+ channel TRPV5 and TRPV6 in human renal cell carcinoma associated with vitamin D receptor
    Yongyang Wu
    Department of Urology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Yamanashi, Japan
    J Urol 186:2419-25. 2011
    ....
  21. doi request reprint Sensor Mechanism and Afferent Signal Transduction of the Urinary Bladder: Special Focus on transient receptor potential Ion Channels
    Masayuki Takeda
    Department of Urology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Yamanashi, JapanDepartment of Urology, The First Affiliated Hospital, China Medical University, Shenyang, ChinaDepartment of Urology, Shiga University of Medical Science, Shiga, Japan
    Low Urin Tract Symptoms 2:51-60. 2010
    ....
  22. ncbi request reprint Symptom assessment tool for overactive bladder syndrome--overactive bladder symptom score
    Yukio Homma
    Department of Urology, Japan Red Cross Medical Center, Tokyo, Japan
    Urology 68:318-23. 2006
    ..Overactive bladder (OAB) is a common symptom syndrome with urgency, urinary frequency, and urgency incontinence. To collectively express OAB symptoms, we developed the overactive bladder symptom score (OABSS)...
  23. ncbi request reprint Modified endoscopic live donor nephrectomy: retroperitoneoscopy followed by hand-assistance
    Yasuhisa Furuya
    Department of Urology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Yamanashi 409 3898, Japan
    Int J Urol 12:603-6. 2005
    ....
  24. doi request reprint Sex differences in the expression profile of acid-sensing ion channels in the mouse urinary bladder: a possible involvement in irritative bladder symptoms
    Hideki Kobayashi
    Department of Urology, University of Yamanashi Interdisciplinary Graduate School of Medicine and Engineering, Chuo, Japan
    BJU Int 104:1746-51. 2009
    ..e. ASIC and transient receptor potential channel V1, TRPV1; both key receptors for extracellular protons that might underlie the acid-evoked pain perception) and other nociceptive ion channels in the mouse bladder...
  25. ncbi request reprint Amiloride-sensitive ion channels in urinary bladder epithelium involved in mechanosensory transduction by modulating stretch-evoked adenosine triphosphate release
    Shuqi Du
    Department of Urology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Chuo, Yamanashi, Japan
    Urology 69:590-5. 2007
    ..To examine the possibility that mechanosensitive ion channels, including epithelial Na+ channels (ENaC), are implicated in mechanosensory transduction of the rat urinary bladder...
  26. ncbi request reprint Decreased expression of G protein-coupled receptor kinases in the detrusor smooth muscle of human urinary bladder with outlet obstruction
    Yasuhisa Furuya
    Department of Urology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Yamanashi, Japan
    Int J Urol 13:1226-32. 2006
    ..Furthermore, we confirm the presence and the localization of GRK proteins in the detrusor smooth muscle of the obstructed bladder in comparison with the control bladder...
  27. doi request reprint Assessment of overactive bladder symptoms: comparison of 3-day bladder diary and the overactive bladder symptoms score
    Yukio Homma
    Department of Urology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Urology 77:60-4. 2011
    ..To compare the Overactive Bladder Symptom Score (OABSS) and a bladder diary as a tool for assessing symptoms of overactive bladder (OAB)...
  28. ncbi request reprint Real-time monitoring of mesangial cell-macrophage cross-talk using SEAP in vitro and ex vivo
    Yiman Meng
    Department of Molecular Signaling, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Tamaho, Yamanashi, Japan
    Kidney Int 68:886-93. 2005
    ..We established a novel system for continuous, real-time monitoring of cross-talk between macrophages and mesangial cells in vitro and ex vivo...
  29. pmc A novel TXNIP-based mechanism for Cx43-mediated regulation of oxidative drug injury
    Kun Gao
    Department of Molecular Signaling, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Chuo, Yamanashi, Japan
    J Cell Mol Med 19:2469-80. 2015
    ..Targeting Cx43/TXNIP/Akt signalling cascade might be a promising approach to modulate cell response to drugs...
  30. pmc Functional role for Piezo1 in stretch-evoked Ca²⁺ influx and ATP release in urothelial cell cultures
    Tatsuya Miyamoto
    From the Department of Urology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, 1110 Shimokato, Chuo, Yamanashi 409 3898
    J Biol Chem 289:16565-75. 2014
    ..These results suggest that Piezo1 senses extension of the bladder urothelium, leading to production of an ATP signal. Thus, inhibition of Piezo1 might provide a promising means of treating bladder dysfunction. ..
  31. doi request reprint 5'-AMP-activated protein kinase attenuates adriamycin-induced oxidative podocyte injury through thioredoxin-mediated suppression of the apoptosis signal-regulating kinase 1-P38 signaling pathway
    Kun Gao
    Departments of Molecular Signaling K G, Y C, J Y and Urology M T, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Yamanashi, Japan and Department of Nephrology, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, People s Republic of China K G, W S
    Mol Pharmacol 85:460-71. 2014
    ..Our findings thus provide novel mechanistic insights into the antioxidative actions of AMPK. AMPK could be developed as a novel therapeutic target for treatment of oxidative cell injury. ..
  32. doi request reprint β-Catenin signaling contributes to platelet derived growth factor elicited bladder smooth muscle cell contraction through up-regulation of Cx43 expression
    Kai Li
    Department of Molecular Signaling, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Chuo, Yamanashi, Japan
    J Urol 188:307-15. 2012
    ..We examined whether and how platelet derived growth factor regulates connexin43 in bladder smooth muscle cells...
  33. ncbi request reprint Multifocal metastases of recurrent renal cell carcinoma successfully treated with a combination of low dose interleukin-2, alpha-interferon and radiotherapy
    Norifumi Sawada
    Yamanashi University School of Medicine, Departments of Urology, Tamaho, Yamanashi, Japan
    Int J Urol 12:994-5. 2005
    ..Six months after the 16 weeks of immunotherapy, computed tomography and bone scintigraphy revealed that the metastases of the lung, liver and bone substantially disappeared and this complete response is still kept after 16 months...
  34. ncbi request reprint Diagnosis and treatment of voiding symptoms
    Masayuki Takeda
    Department of Urology, University of Yamanashi, Faculty of Medicine, Yamanashi, Japan
    Urology 62:11-9. 2003
    ..If no urodynamic abnormalities of either the detrusor or the outlet can be detected despite significant LUTS, factors unrelated to the lower urinary tract may be responsible for the voiding symptoms...
  35. ncbi request reprint Lower urinary tract symptoms in men and women without underlying disease causing micturition disorder: a cross-sectional study assessing the natural history of bladder function
    Isao Araki
    Department of Urology, University of Yamanashi Faculty of Medicine, Yamanashi, 1110 Shimokato, Tamaho, Yamanashi 409 3898, Japan
    J Urol 170:1901-4. 2003
    ..We examined the influence of aging on bladder function in men and women...
  36. pmc The TRPV4 cation channel mediates stretch-evoked Ca2+ influx and ATP release in primary urothelial cell cultures
    Tsutomu Mochizuki
    Department of Urology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Yamanashi 409 3898, Japan
    J Biol Chem 284:21257-64. 2009
    ..These results suggest that TRPV4 senses distension of the bladder urothelium, which is converted to an ATP signal in the micturition reflex pathway during urine storage...
  37. ncbi request reprint Prevalence and impact on generic quality of life of urinary incontinence in Japanese working women: assessment by ICI questionnaire and SF-36 Health Survey
    Isao Araki
    Department of Urology, University of Yamanashi Faculty of Medicine, Yamanashi, Japan
    Urology 66:88-93. 2005
    ..To examine the prevalence of urinary incontinence (UI) and the relationship between UI and generic quality of life (QOL) in working women...
  38. ncbi request reprint Rapid, transient induction of ER stress in the liver and kidney after acute exposure to heavy metal: evidence from transgenic sensor mice
    Nobuhiko Hiramatsu
    Department of Molecular Signaling, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Chuo, Yamanashi 409 3898, Japan
    FEBS Lett 581:2055-9. 2007
    ..It was inversely correlated with the induction of endogenous ER stress markers in the liver and kidney. Our result provides first evidence for the acute, reversible induction of ER stress in vivo after exposure to heavy metal...
  39. doi request reprint Sex-related differences in activity of lower urinary tract in response to intravesical acid irritation in decerebrate unanesthetized mice
    Mitsuharu Yoshiyama
    Department of Urology, University of Yamanashi Interdisciplinary Graduate School of Medicine and Engineering, Chuo, Yamanashi, Japan
    Am J Physiol Regul Integr Comp Physiol 295:R954-60. 2008
    ..Identification of mechanisms underlying sex-specific characteristics might be helpful for elucidating pathogenesis of painful bladder syndrome...
  40. doi request reprint Roles of mechanosensitive ion channels in bladder sensory transduction and overactive bladder
    Isao Araki
    Department of Urology, University of Yamanashi Interdisciplinary Graduate School of Medicine and Engineering, Chuo, Japan
    Int J Urol 15:681-7. 2008
    ..Pharmacological interventions targeting mechanosensitive ion channels may provide a new strategy for the treatment of bladder dysfunction...
  41. pmc Connexin43 hemichannels contributes to the disassembly of cell junctions through modulation of intracellular oxidative status
    Yuan Chi
    Department of Molecular Signaling, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Chuo, Yamanashi, Japan
    Redox Biol 9:198-209. 2016
    ..Taken together, our study indicates that Cx43 hemichannels promote the disassembly of cell junctions through regulation of intracellular oxidative status...
  42. doi request reprint Upregulation of connexin43 contributes to PX-12-induced oxidative cell death
    Gang Li
    Department of Molecular Signaling, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Chuo, Yamanashi, 409 3898, Japan
    Tumour Biol 37:7535-46. 2016
    ..Our results thus indicate that Cx43 is a determinant in the regulation of cell susceptibility to PX-12 and that the upregulation of Cx43 may be an additional mechanism by which PX-12 exerts its anti-tumor actions. ..
  43. pmc Postrenal Failure due to Urinary Stones Associated with Acute Viral Gastroenteritis: Three Case Reports
    Satoru Kira
    Department of Urology, University of Yamanashi Graduate School of Medical Science, 1110 Shimokato Chuo, Yamanashi, Japan
    Case Rep Urol 2016:1375923. 2016
    ..Immediate nephrostomy for the release of upper urinary tract obstruction combined with urinary alkalization as a chemical dissolution therapy should be considered in such cases...
  44. pmc AMPK Suppresses Connexin43 Expression in the Bladder and Ameliorates Voiding Dysfunction in Cyclophosphamide-induced Mouse Cystitis
    Xiling Zhang
    Department of Molecular Signaling, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Yamanashi, Japan
    Sci Rep 6:19708. 2016
    ..We propose that strategies that target AMPK can be developed as novel therapeutic approaches for treating bladder dysfunction. ..
  45. pmc Eviprostat activates cAMP signaling pathway and suppresses bladder smooth muscle cell proliferation
    Kai Li
    Department of Molecular Signaling, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Chuo, Yamanashi 409 3898, Japan
    Int J Mol Sci 14:12107-22. 2013
    ..Collectively, activation of the cAMP signaling pathway could be an important mechanism by which Eviprostat exerts its therapeutic effects for LUTS...
  46. doi request reprint Bladder outlet obstruction induced expression of prostaglandin E2 receptor subtype EP4 in the rat bladder: a possible counteractive mechanism against detrusor overactivity
    Masanori Beppu
    Department of Urology, University of Yamanashi and Interdisciplinary Graduate School of Medicine and Engineering, Yamanashi, Japan
    J Urol 186:2463-9. 2011
    ..We examined how the expression of each EP receptor subtype changed in association with bladder outlet obstruction and focused on the functional role of EP4 receptor subtype in the bladder with outlet obstruction...
  47. ncbi request reprint "Urgency tip": a portable patient-activated device for objective measurement of urinary urgency
    Hideki Kobayashi
    Department of Urology, University of Yamanashi Faculty of Medicine, Chuo, Japan
    Urology 69:570-1. 2007
    ..We have developed a portable patient-activated device to record bladder sensations. This electronic device is pocket-size and light, with five grading buttons and another button for cancellation...
  48. ncbi request reprint Defining overactive bladder as hypersensitivity
    Osamu Yamaguchi
    Department of Urology, Fukushima Medical University, Fukushima, Japan
    Neurourol Urodyn 26:904-7. 2007
    ..This hypersensitivity was observed in our patients regardless of urgency episodes. We therefore hypothesized that OAB may be more accurately defined as a hypersensitivity disorder rather than a syndrome characterized by urgency...
  49. ncbi request reprint Transient receptor potential channel A1 involved in sensory transduction of rat urinary bladder through C-fiber pathway
    Shuqi Du
    Department of Urology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Chuo, Yamanashi, Japan
    Urology 70:826-31. 2007
    ..To investigate the expression and function of the transient receptor potential (TRP) channel A1 in the afferent pathway of rat urinary bladder. The TRPA1 is a candidate for both mechanosensory transduction and nociception...
  50. ncbi request reprint DRESSA: biosensing of dioxin and dioxin-like chemicals using secreted alkaline phosphatase
    Ayumi Kasai
    Department of Biochemistry, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Tamaho, Yamanashi 409 3898, Japan
    Anal Biochem 335:73-80. 2004
    ....
  51. doi request reprint Nocturnal polyuria and hypertension in patients with lifestyle-related diseases and overactive bladder
    Osamu Yokoyama
    Department of Urology, Faculty of Medical Science, University of Fukui, Fukui, Japan Electronic address
    J Urol . 2016
    ..The objective of this multicenter, cross-sectional study was to investigate the relationship of nocturnal polyuria in patients with common lifestyle-related diseases and overactive bladder (OAB), with special attention to hypertension...
  52. pmc Hemorrhagic Renal Angiomyolipoma in Pregnancy Effectively Managed by Immediate Cesarean Section and Elective Transcatheter Arterial Embolization: A Case Report
    Satoru Kira
    Department of Urology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Chuo, Japan
    J Endourol Case Rep 2:65-7. 2016
    ..We present a case of hemorrhagic angiomyolipoma in pregnancy that is effectively managed by immediate cesarean section and elective transcatheter arterial embolization. ..
  53. pmc Laparoscopic Unilateral Total and Contralateral Subtotal Adrenalectomy for Bilateral Adrenocorticotropic Hormone-Secreting Pheochromocytoma: Report of a Rare Case
    Masanari Fukasawa
    Department of Urology, Interdisciplinary Graduate School of Medicine, University of Yamanashi, Yamanashi, Japan
    J Endourol Case Rep 2:232-234. 2016
    ....
  54. doi request reprint Detrusor pressures in urodynamic studies during voiding in women
    Satoru Kira
    Department of Urology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Shimokato 1110, Chuo, Yamanashi, 409 3898, Japan
    Int Urogynecol J . 2016
    ..To investigate detrusor pressure during voiding in women using urodynamic studies (UDS)...
  55. pmc Emerging Families of Ion Channels Involved in Urinary Bladder Nociception
    Isao Araki
    Department of Urology, University of Yamanashi Interdisciplinary Graduate School of Medicine and Engineering, Chuo, Yamanashi 409 3898, Japan
    Pharmaceuticals (Basel) 3:2248-2267. 2010
    ..Pharmacological interventions targeting these ion channels may provide a new strategy for the treatment of pathological bladder sensation and pain...
  56. doi request reprint Suramin inhibits antibody binding to cell surface antigens and disrupts complement-mediated mesangial cell lysis
    Honglan Piao
    Department of Molecular Signaling, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Chuo, Yamanashi, Japan Department of Rehabilitation, The First Affiliated Hospital, Harbin Medical University, Harbin, China
    J Pharmacol Sci . 2016
    ..Our study thus provides novel mechanistic insights into the actions of suramin and suggests that suramin might be used to treat certain immune diseases...
  57. doi request reprint Purinergic control of AMPK activation by ATP released through connexin 43 hemichannels - pivotal roles in hemichannel-mediated cell injury
    Yuan Chi
    Department of Molecular Signaling, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Chuo, Yamanashi 409 3898, Japan
    J Cell Sci 127:1487-99. 2014
    ..Furthermore, we define AMPK as a pivotal molecule that underlies the regulatory effects of hemichannels on cell survival. ..
  58. pmc Effects of urethane on reflex activity of lower urinary tract in decerebrate unanesthetized rats
    Mitsuharu Yoshiyama
    Department of Urology, University of Yamanashi Interdisciplinary Graduate School of Medicine and Engineering, Chuo, Yamanashi, Japan
    Am J Physiol Renal Physiol 304:F390-6. 2013
    ..Because effects of urethane persisted after removal of the forebrain, they must be mediated by actions on the brain stem, spinal cord, or peripheral nervous system...
  59. ncbi request reprint [Laparoscopic adrenalectomy for isolated metastasis of adrenal glands]
    Hidenori Zakoji
    Department of Urology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Yamanashi, Japan
    Nihon Hinyokika Gakkai Zasshi 103:535-9. 2012
    ..The treatment of adrenal metastases using laparoscopic surgery still remains a matter of considerable controversy. The aim of this study is to present our experience of laparoscopic adrenalectomy for isolated adrenal metastasis...
  60. ncbi request reprint Nitric oxide-mediated regulation of connexin43 expression and gap junctional intercellular communication in mesangial cells
    Jian Yao
    Department of Molecular Signaling, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Tamaho, Yamanashi 409 3898, Japan
    J Am Soc Nephrol 16:58-67. 2005
    ..Taken together, the results suggest that NO is involved in the control of GJIC and Cx43 expression. This effect of NO is due to activation of protein kinase A via cGMP-dependent inhibition of PDE3 activity...
  61. ncbi request reprint Real-time quantitative analysis for human telomerase reverse transcriptase mRNA and human telomerase RNA component mRNA expressions as markers for clinicopathologic parameters in urinary bladder cancer
    Yoshio Takihana
    Department of Urology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Yamanashi, Japan
    Int J Urol 13:401-8. 2006
    ..We evaluated the relationship between mRNA quantification of both hTERT and hTR and clinicopathologic parameters in bladder cancer...
  62. ncbi request reprint Retroperitoneoscopic nephron-sparing surgery of renal tumor using a microwave tissue coagulator without renal ischemia: comparison with open procedure
    Yasuhisa Furuya
    Department of Urology, Yamanashi Medical University, Yamanashi, Japan
    J Endourol 17:53-8. 2003
    ..We compared the results of retroperitoneoscopic nephron-sparing surgery for small renal tumors using a microwave tissue coagulator without renal pedicle clamping with those of a retroperitoneal open procedure...
  63. doi request reprint Incontinence and detrusor dysfunction associated with pelvic organ prolapse: clinical value of preoperative urodynamic evaluation
    Isao Araki
    Department of Urology, University of Yamanashi Faculty of Medicine, Chuo, Yamanashi, Japan
    Int Urogynecol J Pelvic Floor Dysfunct 20:1301-6. 2009
    ..We examined how preoperative urodynamic findings are related to the urinary problems following surgical repair of pelvic organ prolapse (POP)...
  64. doi request reprint Melatonin Improves Erectile Function in Rats With Chronic Lower Body Ischemia
    Norifumi Sawada
    Wake Forest Institute for Regenerative Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA Department of Urology, Interdisciplinary Graduate School of Medicine, University of Yamanashi, Chuo City, Yamanashi, Japan Electronic address
    J Sex Med 13:179-86. 2016
    ..Using an established rat model we wanted to characterize the changes caused by atherosclerosis-induced chronic ischemia on penile structures and erectile function...
  65. doi request reprint Ejaculation disorder is associated with increased efficacy of silodosin for benign prostatic hyperplasia
    Yukio Homma
    Department of Urology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Urology 76:1446-50. 2010
    ..To provide clinical evidence that ejaculation disorder caused by selective alpha(1A)-blockers may be associated with larger symptomatic improvements in patients with benign prostatic hyperplasia...
  66. ncbi request reprint [Two cases of infants with acute renal failure due to bilateral obstructive ureteral stones associated with rotavirus gastroenteritis]
    Hidenori Zakoji
    Department of Urology, Faculty of Medicine, University of Yamanashi
    Nihon Hinyokika Gakkai Zasshi 101:29-33. 2010
    ..It has been known that the cause of acute renal failure is renal azotemia resulting from sustained hypovolemia, but post-renal causes due to ammonium acid urate stones should be taken into consideration...
  67. doi request reprint Randomized Controlled Trial to Treat Benign Prostatic Hyperplasia with Overactive Bladder Using an Alpha-blocker Combined with Anticholinergics
    Osamu Nishizawa
    Department of Urology, Shinshu University School of Medicine, Matsumoto, JapanDepartment of Urology, Fukushima Medical University School of Medicine, Fukushima, JapanDepartment of Urology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Koufu, JapanDepartment of Urology, University of Fukui, Fukui, Japan
    Low Urin Tract Symptoms 3:29-35. 2011
    ..TAABO was a randomized, controlled trial to evaluate the efficacy and safety of combination therapy of tamsulosin (TAM) with propiverine (PROP) in men with both benign prostatic hyperplasia and overactive bladder...
  68. doi request reprint Efficacy, Safety and Tolerability of Fesoterodine in Asian Patients with Overactive Bladder
    Osamu Yamaguchi
    Department of Urology, Fukushima Medical University School of Medicine, Fukushima, JapanDepartment of Urology, Shinshu University School of Medicine, Nagano, JapanDepartment of Urology, Yamanashi University, Yamanashi, JapanDepartment of Medical Informatics, Japan Labor Health and Welfare Organization, Kumamoto Rosai Hospital, Kumamoto, JapanDepartment of Urology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, KoreaDepartment of Urology, College of Medicine, Korea University, Seoul, KoreaDepartment of Surgery, Taipei Veterans General Hospital and National Yang Ming University, Taipei, TaiwanDepartment of Obstetrics and Gynecology, National Taiwan University Hospital, Taipei, TaiwanDepartment of Surgery, Kwong Wah Hospital, Hong Kong, ChinaPfizer Japan Inc, Tokyo, Japan
    Low Urin Tract Symptoms 3:43-50. 2011
    ..To assess the efficacy, safety, and tolerability of fesoterodine 4 and 8 mg once daily (QD) compared with placebo in Asian subjects with overactive bladder (OAB) after 12 weeks of treatment...
  69. doi request reprint Early Efficacy of an α1 Adrenoceptor Antagonist, Naftopidil, against Lower Urinary Tract Symptoms Suggestive of Benign Prostatic Hyperplasia
    Osamu Ishizuka
    Department of Urology, Shinshu University School of Medicine, Matsumoto, JapanDepartment of Urology, Interdisciplinary Graduate School of Medicine, University of Yamanashi, Chuo, JapanDepartment of Urology, Institute of Health Biosciences, University of Tokushima Graduate School, Tokushima, Japan
    Low Urin Tract Symptoms 3:79-85. 2011
    ..The present study investigated the early efficacy of naftopidil against lower urinary tract symptoms (LUTS) suggestive of benign prostatic hyperplasia (BPH)...
  70. doi request reprint Tadalafil for the Treatment of Lower Urinary Tract Symptoms in Japanese Men with Benign Prostatic Hyperplasia: Results from a 12-week Placebo-controlled Dose-finding Study with a 42-week Open-label Extension
    Masayuki Takeda
    Department of Urology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Chuo, JapanDepartment of Urology, Shinshu University School of Medicine, Matsumoto, JapanLilly Research Laboratories Japan, Eli Lilly Japan K K, Kobe, JapanLilly Research Laboratories, Eli Lilly and Co, Indianapolis, USA
    Low Urin Tract Symptoms 4:110-9. 2012
    ..To examine the efficacy, safety, and dose response of tadalafil once daily in Japanese men with lower urinary tract symptoms suggestive of benign prostatic hyperplasia (BPH-LUTS)...
  71. pmc Suppression of cell membrane permeability by suramin: involvement of its inhibitory actions on connexin 43 hemichannels
    Yuan Chi
    Department of Molecular Signaling, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Chuo, Yamanashi, Japan
    Br J Pharmacol 171:3448-62. 2014
    ....
  72. ncbi request reprint The methylentetrahydrofolate reductase C677T point mutation is a risk factor for vascular access thrombosis in hemodialysis patients
    Mizuya Fukasawa
    Department of Urology and Faculty of Medicine, University of Yamanashi, Japan
    Am J Kidney Dis 41:637-42. 2003
    ..The methylentetrahydrofolate reductase (MTHFR) C677T polymorphism has been reported to be closely related to plasma Hcy level...
  73. ncbi request reprint AP-1-independent sensitization to oxidative stress-induced apoptosis by proteasome inhibitors
    Nobuhiko Hiramatsu
    Department of Biochemistry, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Tamaho, Yamanashi 409 3898, Japan
    Biochem Biophys Res Commun 316:545-52. 2004
    ..Interestingly, pretreatment with MG132 did not enhance activation of AP-1 by H(2)O(2). These data suggested a novel, AP-1-independent promotion of apoptosis by proteasome inhibitors...
  74. ncbi request reprint Relationship of bladder dysfunction to lesion site in multiple sclerosis
    Isao Araki
    Department of Urology, Utano National Hospital, Kyoto, Japan
    J Urol 169:1384-7. 2003
    ..We investigated the relationship of voiding dysfunction type and the lesion site in patients with multiple sclerosis...
  75. ncbi request reprint A novel salvage technique that does not require catheter removal for exit-site infection
    Mizuya Fukasawa
    Department of Urology, Yamanashi Medical University, Tamaho, Japan
    Perit Dial Int 22:618-21. 2002
  76. ncbi request reprint Inhibition of c-Jun N-terminal kinase ameliorates apoptosis induced by hydrogen peroxide in the kidney tubule epithelial cells (NRK-52E)
    Liming Wang
    Department of Urology, Yamanashi Medical University, Tamaho, Yamanashi, Japan
    Nephron 91:142-7. 2002
    ..The present study was designed to investigate JNK activation and the effects of the JNK pathway inhibition during H2O2-induced apoptosis in kidney epithelial tubule cells (NRK-52E)...
  77. doi request reprint Tadalafil 5 mg once-daily therapy for men with lower urinary tract symptoms suggestive of benign prostatic hyperplasia: results from a randomized, double-blind, placebo-controlled trial carried out in Japan and Korea
    Masayuki Takeda
    Department of Urology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Yamanashi, Japan
    Int J Urol 21:670-5. 2014
    ..To gain further evidence on the efficacy, safety and tolerability of tadalafil 5 mg once-daily in Asian men with lower urinary tract symptoms suggestive of benign prostatic hyperplasia...
  78. ncbi request reprint Intraperitoneal rupture of giant hydronephrosis due to ureteral cancer accompanied by renal cell carcinoma
    Mizuya Fukasawa
    Department of Urology, Shimoina Red Cross Hospital, Shimoina, Japan
    J Urol 167:1393-4. 2002
  79. doi request reprint Endovascular treatment of ureteroarterial fistulas with stent-grafts
    Takuji Araki
    Department of Radiology, Faculty of Medicine, University of Yamanashi, 1110 Shimokato, Chuo 409 3898, Japan
    Radiat Med 26:372-5. 2008
    ..The hematuria did not recur up to the last follow-up visits of 3 and 19 months, respectively...
  80. ncbi request reprint [Molecular biological researches of the lower urinary tract function]
    Masayuki Takeda
    Department of Urology, University of Yamanashi Faculty of Medicine, Yamanashi 409 3898, Japan
    Nihon Yakurigaku Zasshi 121:325-30. 2003
    ..In the near future, agonist for the adrenergic beta3 receptor and selective antagonists for VR1, VRL1, or P2X3 will possibly become drugs for pollakisuria and urge urinary incontinence...