Akira Saito

Summary

Affiliation: University of Tokyo
Country: Japan

Publications

  1. doi request reprint Hippo and TGF-β interplay in the lung field
    Akira Saito
    Department of Respiratory Medicine, Graduate School of Medicine, The University of Tokyo, Hongo, Bunkyo ku, Tokyo, Japan and Division for Health Service Promotion, The University of Tokyo, Hongo, Bunkyo ku, Tokyo, Japan
    Am J Physiol Lung Cell Mol Physiol 309:L756-67. 2015
  2. pmc Differential knockdown of TGF-β ligands in a three-dimensional co-culture tumor- stromal interaction model of lung cancer
    Masafumi Horie
    Department of Respiratory Medicine, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    BMC Cancer 14:580. 2014
  3. ncbi request reprint Potential action of IL-4 and IL-13 as fibrogenic factors on lung fibroblasts in vitro
    Akira Saito
    Department of Respiratory Medicine, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Int Arch Allergy Immunol 132:168-76. 2003
  4. ncbi request reprint A case of pulmonary veno-occlusive disease associated with systemic sclerosis
    Akira Saito
    Department of Respiratory Medicine, Graduate School of Medicine, University of Tokyo, Japan
    Respirology 8:383-5. 2003
  5. pmc An integrated expression profiling reveals target genes of TGF-β and TNF-α possibly mediated by microRNAs in lung cancer cells
    Akira Saito
    Department of Respiratory Medicine, Graduate School of Medicine, The University of Tokyo, Bunkyo ku, Tokyo, Japan
    PLoS ONE 8:e56587. 2013
  6. doi request reprint EMT and EndMT: regulated in similar ways?
    Akira Saito
    Division for Health Service Promotion, University of Tokyo, 7 3 1, Hongo, Bunkyo ku, Tokyo, 113 0033, Japan
    J Biochem 153:493-5. 2013
  7. ncbi request reprint [Tuberculosis complicated with liver cirrhosis]
    Akira Saito
    Department of Respiratory Disease, National Hospital Organization Tokyo National Hospital
    Kekkaku 81:457-65. 2006
  8. doi request reprint A new aspect of metastasis in cutaneous cancer: two cases of presacral squamous cell carcinoma with metastases to internal iliac nodes
    Kohei Oashi
    Department of Plastic and Reconstructive Surgery, Graduate School of Medicine, University of Hokkaido at Sapporo, Sapporo, Japan
    Ann Plast Surg 70:79-81. 2013
  9. doi request reprint Merkel cell carcinoma of the face: an analysis of 16 cases in the Japanese
    Akira Saito
    Department of Plastic and Reconstructive Surgery, Graduate School of Medicine, Hokkaido University, Kita 15, Nishi 7, Kita ku, Sapporo 060 8638, Japan
    J Plast Reconstr Aesthet Surg 62:1272-6. 2009
  10. doi request reprint Sentinel lymph node biopsy using real-time fluorescence navigation with indocyanine green in cutaneous head and neck/lip mucosa melanomas
    Toshihiko Hayashi
    Department of Plastic and Reconstructive Surgery, Graduate School of Medicine, Hokkaido University, Sapporo, Japan
    Head Neck 34:758-61. 2012

Detail Information

Publications34

  1. doi request reprint Hippo and TGF-β interplay in the lung field
    Akira Saito
    Department of Respiratory Medicine, Graduate School of Medicine, The University of Tokyo, Hongo, Bunkyo ku, Tokyo, Japan and Division for Health Service Promotion, The University of Tokyo, Hongo, Bunkyo ku, Tokyo, Japan
    Am J Physiol Lung Cell Mol Physiol 309:L756-67. 2015
    ..In this review, we summarize the current knowledge of the Hippo pathway regarding lung development and diseases, with an emphasis on its interplay with TGF-β signaling. ..
  2. pmc Differential knockdown of TGF-β ligands in a three-dimensional co-culture tumor- stromal interaction model of lung cancer
    Masafumi Horie
    Department of Respiratory Medicine, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    BMC Cancer 14:580. 2014
    ..In addition, differential effects due to knockdown of various TGF-β ligand isoforms have not been examined. Therefore, an experimental model that recapitulates tumor-stromal interaction is required for validation of therapeutic agents...
  3. ncbi request reprint Potential action of IL-4 and IL-13 as fibrogenic factors on lung fibroblasts in vitro
    Akira Saito
    Department of Respiratory Medicine, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Int Arch Allergy Immunol 132:168-76. 2003
    ..We hypothesized that these cytokines would stimulate fibroblast proliferation in association with decreased prostaglandin E(2) (PGE(2))...
  4. ncbi request reprint A case of pulmonary veno-occlusive disease associated with systemic sclerosis
    Akira Saito
    Department of Respiratory Medicine, Graduate School of Medicine, University of Tokyo, Japan
    Respirology 8:383-5. 2003
    ..The patient died 7 months later and at autopsy the lungs showed prominent thickening of the interlobular septa and small branches of pulmonary veins showed intimal thickening...
  5. pmc An integrated expression profiling reveals target genes of TGF-β and TNF-α possibly mediated by microRNAs in lung cancer cells
    Akira Saito
    Department of Respiratory Medicine, Graduate School of Medicine, The University of Tokyo, Bunkyo ku, Tokyo, Japan
    PLoS ONE 8:e56587. 2013
    ..These findings provide a line of evidence that the effects of TGF-β and TNF-α were partially mediated by microRNAs, and shed light on the complexity of molecular events elicited by TGF-β and TNF-α...
  6. doi request reprint EMT and EndMT: regulated in similar ways?
    Akira Saito
    Division for Health Service Promotion, University of Tokyo, 7 3 1, Hongo, Bunkyo ku, Tokyo, 113 0033, Japan
    J Biochem 153:493-5. 2013
    ..These recent works unraveled discrete regulatory networks in mesenchymal transition of epithelial and endothelial cells...
  7. ncbi request reprint [Tuberculosis complicated with liver cirrhosis]
    Akira Saito
    Department of Respiratory Disease, National Hospital Organization Tokyo National Hospital
    Kekkaku 81:457-65. 2006
    ..The aim of this study is to examine the clinical characteristics of tuberculous patients complicated with liver cirrhosis...
  8. doi request reprint A new aspect of metastasis in cutaneous cancer: two cases of presacral squamous cell carcinoma with metastases to internal iliac nodes
    Kohei Oashi
    Department of Plastic and Reconstructive Surgery, Graduate School of Medicine, University of Hokkaido at Sapporo, Sapporo, Japan
    Ann Plast Surg 70:79-81. 2013
    ..These cases provide insights into the potential pathway through which a cutaneous tumor disseminates...
  9. doi request reprint Merkel cell carcinoma of the face: an analysis of 16 cases in the Japanese
    Akira Saito
    Department of Plastic and Reconstructive Surgery, Graduate School of Medicine, Hokkaido University, Kita 15, Nishi 7, Kita ku, Sapporo 060 8638, Japan
    J Plast Reconstr Aesthet Surg 62:1272-6. 2009
    ..There is no agreement regarding a staging system and optimal treatment of Merkel cell carcinoma. Some centres have reported results from larger series of patients, but these do not include Asian or Japanese centres...
  10. doi request reprint Sentinel lymph node biopsy using real-time fluorescence navigation with indocyanine green in cutaneous head and neck/lip mucosa melanomas
    Toshihiko Hayashi
    Department of Plastic and Reconstructive Surgery, Graduate School of Medicine, Hokkaido University, Sapporo, Japan
    Head Neck 34:758-61. 2012
    ..To get around the shine-through phenomenon, this study uses the fluorescence navigation with indocyanine green (ICG) as well as the triple technique...
  11. doi request reprint An integrative analysis of the tumorigenic role of TAZ in human non-small cell lung cancer
    Satoshi Noguchi
    Department of Respiratory Medicine, Graduate School of Medicine, The University of Tokyo, Bunkyo ku, Tokyo, Japan
    Clin Cancer Res 20:4660-72. 2014
    ..TAZ, also known as WWTR1, has recently been suggested as an oncogene in non-small cell lung cancer (NSCLC). We investigated the clinical relevance of TAZ expression and its functional role in NSCLC tumorigenesis...
  12. doi request reprint Characterization of human lung cancer-associated fibroblasts in three-dimensional in vitro co-culture model
    Masafumi Horie
    Department of Respiratory Medicine, Graduate School of Medicine, University of Tokyo, Japan
    Biochem Biophys Res Commun 423:158-63. 2012
    ..These observations provide evidence that lung CAFs have the tumor-promoting capacity distinct from NFs...
  13. doi request reprint Dominant lymph drainage in the facial region: evaluation of lymph nodes of facial melanoma patients
    Toshihiko Hayashi
    Department of Plastic and Reconstructive Surgery, Graduate School of Medicine, Hokkaido University, Kita 15, Nishi 7, Kita ku, Sapporo, 060 8638, Japan
    Int J Clin Oncol 17:330-5. 2012
    ..The purpose of this study was to evaluate the superficial lymph drainage patterns from primary lesions, with the primary focus on cheek/eyelid and lip melanomas...
  14. doi request reprint Reconstruction of periorbital defects following malignant tumour excision: a report of 50 cases
    Akira Saito
    Department of Plastic and Reconstructive Surgery, Graduate School of Medicine, Hokkaido University, Sapporo, Japan
    J Plast Reconstr Aesthet Surg 65:665-70. 2012
    ..Treatment in malignant periorbital tumours requires a radical resection of the tumour, and reconstruction of eyelid defects is difficult task because it should aim at gaining functional and aesthetical improvement...
  15. doi request reprint Laminin-421 produced by lymphatic endothelial cells induces chemotaxis for human melanoma cells
    Noriko Saito
    Department of Plastic and Reconstructive Surgery, Graduate School of Medicine, Hokkaido University, Sapporo, Japan
    Pigment Cell Melanoma Res 22:601-10. 2009
    ..These data suggest that laminin-421 secreted by LEC possibly facilitates lymphatic metastasis through the induction of chemotaxis of melanoma cells...
  16. doi request reprint A genome-wide association study identifies two new susceptibility loci for lung adenocarcinoma in the Japanese population
    Kouya Shiraishi
    Division of Genome Biology, National Cancer Center Research Institute, Tokyo, Japan
    Nat Genet 44:900-3. 2012
    ..4 × 10(-11), OR = 1.20) and 6p21.3 (rs3817963, P(combined) = 2.7 × 10(-10), OR = 1.18). These data provide further evidence supporting a role for genetic susceptibility in the development of lung adenocarcinoma...
  17. doi request reprint Minor-form/microform cleft lip repair: the importance of identification and utilization of Cupid bow peak on the lateral lip
    Akihiko Oyama
    From the Department of Plastic and Reconstructive Surgery, Graduate School of Medicine, Hokkaido University, Sapporo, Hokkaido, Japan
    Ann Plast Surg 72:47-9. 2014
    ..Details of our concept for the correction of minor-form or microform cleft lip are also introduced...
  18. doi request reprint Histamine induces human lung fibroblast-mediated collagen gel contraction via histamine H1 receptor
    Masafumi Horie
    1Department of Respiratory Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Exp Lung Res 40:222-36. 2014
    ..Histamine is a potent mediator of allergic inflammation, substantially involved in asthmatic pathophysiology...
  19. doi request reprint A new uniform protocol of combined corticosteroid injections and ointment application reduces recurrence rates after surgical keloid/hypertrophic scar excision
    Toshihiko Hayashi
    Department of Plastic and Reconstructive Surgery, Graduate School of Medicine, Hokkaido University, Sapporo, Hokkaido, Japan
    Dermatol Surg 38:893-7. 2012
    ..Additionally, few of these studies employed a standardized treatment protocol...
  20. doi request reprint Direction of innervation after interpositional nerve graft between facial and hypoglossal nerves in individuals with or without facial palsy: a rat model for treating incomplete facial palsy
    Ryuji Shichinohe
    Department of Plastic and Reconstructive Surgery, Graduate School of Medicine, University of Hokkaido at Sapporo UHS, Kita 15 Nishi 7, Kita ku, Sapporo, Hokkaido 060 8638, Japan
    J Plast Reconstr Aesthet Surg 65:763-70. 2012
    ..However, its mechanism has not been elucidated. We established a rat model of IPNG to study incomplete facial palsy and confirmed the direction of innervation through the grafted nerve with or without facial nerve injury...
  21. doi request reprint Microsurgical lymphaticovenous implantation targeting dermal lymphatic backflow using indocyanine green fluorescence lymphography in the treatment of postmastectomy lymphedema
    Hiroshi Furukawa
    Department of Plastic and Reconstructive Surgery, Graduate School of Medicine, University of Hokkaido at Sapporo, Sapporo, Japan
    Plast Reconstr Surg 127:1804-11. 2011
    ..The authors have recently introduced ultrasonograpy and indocyanine green fluorescence lymphography into this procedure...
  22. doi request reprint A functional single nucleotide polymorphism in mucin 1, at chromosome 1q22, determines susceptibility to diffuse-type gastric cancer
    Norihisa Saeki
    Genetics Division, National Cancer Center Research Institute, Tokyo, Japan
    Gastroenterology 140:892-902. 2011
    ....
  23. doi request reprint Simvastatin inhibits growth via apoptosis and the induction of cell cycle arrest in human melanoma cells
    Akira Saito
    Department of Plastic and Reconstructive Surgery, Graduate School of Medicine, Hokkaido University, Kita ku, Sapporo, Japan
    Melanoma Res 18:85-94. 2008
    ..We conclude that simvastatin has an antitumor effect on human melanoma cells in vitro via apoptosis and cell cycle arrest. These results suggest that simvastatin may be an effective anticancer drug for malignant melanoma...
  24. pmc YAP and TAZ modulate cell phenotype in a subset of small cell lung cancer
    Masafumi Horie
    Department of Respiratory Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Cancer Sci 107:1755-1766. 2016
    ..Our findings shed light on a subtype of SCLC with YAP and TAZ expression, and delineate molecular networks underlying the heterogeneity of SCLC...
  25. doi request reprint Dominant lymph drainage in the upper extremity and upper trunk region: evaluation of lymph drainage in patients with skin melanomas
    Toshihiko Hayashi
    Department of Plastic and Reconstructive Surgery, Graduate School of Medicine, Hokkaido University, Kita 15, Nishi 7, Kita ku, Sapporo, 060 8638, Japan
    Int J Clin Oncol 19:193-7. 2014
    ..The objective of this study is to evaluate the lymph drainage from the primary focus to the regional lymph nodes in patients with melanomas of the upper extremity and upper trunk region...
  26. doi request reprint An analysis of cheek reconstruction after tumor excision in patients with melanoma
    Toshihiko Hayashi
    From the Department of Plastic and Reconstructive Surgery, Graduate School of Medicine, Hokkaido University, Sapporo, Japan
    J Craniofac Surg 25:e98-101. 2014
    ..This study evaluated factors that influence the selection of reconstructive procedures after excision of a cheek melanoma...
  27. doi request reprint Prostate stem cell antigen, a presumable organ-dependent tumor suppressor gene, is down-regulated in gallbladder carcinogenesis
    Hiroe Ono
    Division of Genetics, National Cancer Center Research Institute, Tokyo, Japan
    Genes Chromosomes Cancer 51:30-41. 2012
    ..These lines of in vivo and in vitro evidence suggest that PSCA is acting as a tumor suppressor in GBC development...
  28. ncbi request reprint Sebaceous carcinoma of the eyelids: a review of 21 cases
    Akira Saito
    Department of Plastic and Reconstructive Surgery, Graduate School of Medicine, Hokkaido University, Kita 15, Nishi 7, Kita ku, Sapporo 060 8638, Japan
    J Plast Reconstr Aesthet Surg 61:1328-31. 2008
    ..In this article, we studied the management and outcomes of sebaceous carcinoma using the T classification...
  29. pmc Transcriptome analysis of periodontitis-associated fibroblasts by CAGE sequencing identified DLX5 and RUNX2 long variant as novel regulators involved in periodontitis
    Masafumi Horie
    Department of Respiratory Medicine, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Sci Rep 6:33666. 2016
    ..Down-regulation of these transcription factors in PAFs could be associated with their property to degrade collagen, which may impact on the process of periodontitis. ..
  30. doi request reprint Novel swine model of transfusion-related acute lung injury
    Hitoshi Okazaki
    Research and Development Department, Central Blood Institute, Blood Service Headquarters, Japanese Red Cross Society, Tokyo, Japan Department of Transfusion Medicine, The University of Tokyo, Tokyo, Japan
    Transfusion 54:3097-107. 2014
    ..Although sheep models of nonimmune TRALI have been developed, large-animal models of antibody-mediated TRALI are not yet available...
  31. pmc Genome-wide association study of pancreatic cancer in Japanese population
    Siew Kee Low
    Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, Department of Medical Genome Sciences, Graduate School of Frontier Scineces, The University of Tokyo, National Cancer Center Hospital, Tokyo, Japan
    PLoS ONE 5:e11824. 2010
    ..3, 12p11.21 and 7q36.2, respectively. These associated SNPs are located within linkage disequilibrium blocks containing genes that have been implicated some roles in the oncogenesis of pancreatic cancer...
  32. ncbi request reprint Evaluation of the sclerotherapeutic efficacy of ethanol, polidocanol, and OK-432 using an in vitro model
    William Mol
    Department of Plastic and Reconstructive Surgery, University of Hokkaido at Sapporo, Graduate School of Medicine, Sapporo, Japan
    Dermatol Surg 33:1452-9. 2007
    ..Owing to variations in the flow, the injected concentrations and the duration of exposure of these sclerosants are altered. Therefore, the clinical effectiveness of sclerotherapy is variable...
  33. pmc Prox1 induces lymphatic endothelial differentiation via integrin alpha9 and other signaling cascades
    Koichi Mishima
    Department of Molecular Pathology, Graduate School of Medicine, University of Tokyo, Tokyo 113 0033, Japan
    Mol Biol Cell 18:1421-9. 2007
    ....
  34. doi request reprint NDesign: software for study design for the detection of rare variants from next-generation sequencing data
    Yuki Sugaya
    Statistical Genetics Analysis Division, StaGen Co, Ltd, Tokyo, Japan
    J Hum Genet 57:676-8. 2012
    ..It has a simple implementation in the JavaScript language, and is expected to enable researchers to design optimal NGS studies...