Seishi Ogawa

Summary

Affiliation: University of Tokyo
Country: Japan

Publications

  1. pmc Alterations of the genes involved in the PI3K and estrogen-receptor pathways influence outcome in human epidermal growth factor receptor 2-positive and hormone receptor-positive breast cancer patients treated with trastuzumab-containing neoadjuvant chemot
    Mamoru Takada
    Department of Cancer Diagnosis, Research Institute for Clinical Oncology, Saitama Cancer Center, 818 Komuro, Ina, Saitama, 362 0806, Japan
    BMC Cancer 13:241. 2013
  2. pmc Allelotypes of lung adenocarcinomas featuring ALK fusion demonstrate fewer onco- and suppressor gene changes
    Hironori Ninomiya
    Division of Pathology, The Cancer Institute, Ariake 3 8 31, Koutou ku, Tokyo 135 8550, Japan
    BMC Cancer 13:8. 2013
  3. doi request reprint Deep sequencing in cancer research
    Kenichi Yoshida
    Cancer Genomics Project, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Jpn J Clin Oncol 43:110-5. 2013
  4. doi request reprint Splicing factor mutations in myelodysplasia
    Seishi Ogawa
    Cancer Genomics Project, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Int J Hematol 96:438-42. 2012
  5. ncbi request reprint Gain-of-function c-CBL mutations associated with uniparental disomy of 11q in myeloid neoplasms
    Seishi Ogawa
    Cancer Genomics Project, University of Tokyo, Bunkyo ku, Tokyo, Japan
    Cell Cycle 9:1051-6. 2010
  6. doi request reprint Oncogenic mutations of ALK in neuroblastoma
    Seishi Ogawa
    Cancer Genomics Project, The University of Tokyo, Tokyo, Japan
    Cancer Sci 102:302-8. 2011
  7. doi request reprint Deregulated intracellular signaling by mutated c-CBL in myeloid neoplasms
    Seishi Ogawa
    Cancer Genomics Project, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, Japan
    Clin Cancer Res 16:3825-31. 2010
  8. doi request reprint Evi-1 is a critical regulator for hematopoietic stem cells and transformed leukemic cells
    Susumu Goyama
    Department of Hematology and Oncology, Graduate School of Medicine, University of Tokyo, The University of Tokyo Hospital, Tokyo 113 8655, Japan
    Cell Stem Cell 3:207-20. 2008
  9. doi request reprint Gain of GRHL2 is associated with early recurrence of hepatocellular carcinoma
    Yasuo Tanaka
    Department of Gastroenterology, Graduate School of Medicine, University of Tokyo, Bunkyo ku, Tokyo 113 8655, Japan
    J Hepatol 49:746-57. 2008
  10. pmc Highly sensitive method for genomewide detection of allelic composition in nonpaired, primary tumor specimens by use of affymetrix single-nucleotide-polymorphism genotyping microarrays
    Go Yamamoto
    Departments of Hematology and Oncology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Am J Hum Genet 81:114-26. 2007

Detail Information

Publications88

  1. pmc Alterations of the genes involved in the PI3K and estrogen-receptor pathways influence outcome in human epidermal growth factor receptor 2-positive and hormone receptor-positive breast cancer patients treated with trastuzumab-containing neoadjuvant chemot
    Mamoru Takada
    Department of Cancer Diagnosis, Research Institute for Clinical Oncology, Saitama Cancer Center, 818 Komuro, Ina, Saitama, 362 0806, Japan
    BMC Cancer 13:241. 2013
    ..The mechanisms of recurrence and biomarkers that indicate the response to the chemotherapy and outcome are not fully investigated...
  2. pmc Allelotypes of lung adenocarcinomas featuring ALK fusion demonstrate fewer onco- and suppressor gene changes
    Hironori Ninomiya
    Division of Pathology, The Cancer Institute, Ariake 3 8 31, Koutou ku, Tokyo 135 8550, Japan
    BMC Cancer 13:8. 2013
    ..EML4-ALK fusion confers a characteristic histology and is detected more frequently in never or light smokers and younger patients...
  3. doi request reprint Deep sequencing in cancer research
    Kenichi Yoshida
    Cancer Genomics Project, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Jpn J Clin Oncol 43:110-5. 2013
    ..In this review, we briefly overview the recent advances in cancer research obtained through the massive effort of sequencing cancer genomes...
  4. doi request reprint Splicing factor mutations in myelodysplasia
    Seishi Ogawa
    Cancer Genomics Project, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Int J Hematol 96:438-42. 2012
    ..Largely specific to myelodysplastic phenotypes, these splicing factor mutations provide a potential clue to better understanding of the pathogenesis of MDS...
  5. ncbi request reprint Gain-of-function c-CBL mutations associated with uniparental disomy of 11q in myeloid neoplasms
    Seishi Ogawa
    Cancer Genomics Project, University of Tokyo, Bunkyo ku, Tokyo, Japan
    Cell Cycle 9:1051-6. 2010
    ..In this review, we summarize our current knowledge about c-CBL mutations and discuss the molecular mechanisms of their gain-of-function...
  6. doi request reprint Oncogenic mutations of ALK in neuroblastoma
    Seishi Ogawa
    Cancer Genomics Project, The University of Tokyo, Tokyo, Japan
    Cancer Sci 102:302-8. 2011
    ....
  7. doi request reprint Deregulated intracellular signaling by mutated c-CBL in myeloid neoplasms
    Seishi Ogawa
    Cancer Genomics Project, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, Japan
    Clin Cancer Res 16:3825-31. 2010
    ..The inhibition of mutant CBL protein or signaling pathways that it activates would have a role in therapeutics of myeloid neoplasms with CBL mutations...
  8. doi request reprint Evi-1 is a critical regulator for hematopoietic stem cells and transformed leukemic cells
    Susumu Goyama
    Department of Hematology and Oncology, Graduate School of Medicine, University of Tokyo, The University of Tokyo Hospital, Tokyo 113 8655, Japan
    Cell Stem Cell 3:207-20. 2008
    ..Thus, Evi-1 is a common and critical regulator essential for proliferation of embryonic/adult HSCs and transformed leukemic cells...
  9. doi request reprint Gain of GRHL2 is associated with early recurrence of hepatocellular carcinoma
    Yasuo Tanaka
    Department of Gastroenterology, Graduate School of Medicine, University of Tokyo, Bunkyo ku, Tokyo 113 8655, Japan
    J Hepatol 49:746-57. 2008
    ..The aim of this study is to identify genomic changes that might be implicated in hepatocellular carcinoma (HCC) progression, and evaluate the associations with clinico-pathological features...
  10. pmc Highly sensitive method for genomewide detection of allelic composition in nonpaired, primary tumor specimens by use of affymetrix single-nucleotide-polymorphism genotyping microarrays
    Go Yamamoto
    Departments of Hematology and Oncology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Am J Hum Genet 81:114-26. 2007
    ..In conclusion, AsCNAR should substantially improve our ability to dissect the complexity of cancer genomes and should contribute to our understanding of the genetic basis of human cancers...
  11. ncbi request reprint Identification of a SRC-like tyrosine kinase gene, FRK, fused with ETV6 in a patient with acute myelogenous leukemia carrying a t(6;12)(q21;p13) translocation
    Noriko Hosoya
    Department of Hematology and Oncology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Genes Chromosomes Cancer 42:269-79. 2005
    ....
  12. ncbi request reprint Functional domains of Runx1 are differentially required for CD4 repression, TCRbeta expression, and CD4/8 double-negative to CD4/8 double-positive transition in thymocyte development
    Masahito Kawazu
    Department of Hematology and Oncology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    J Immunol 174:3526-33. 2005
    ..These results suggest that the activation domain is essential for Runx1 to establish thymocyte development and that Runx1 has both TLE-dependent and TLE-independent functions in thymocyte development...
  13. doi request reprint The landscape of somatic mutations in Down syndrome-related myeloid disorders
    Kenichi Yoshida
    1 Cancer Genomics Project, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan 2 Department of Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University, Kyoto, Japan 3
    Nat Genet 45:1293-9. 2013
    ....
  14. ncbi request reprint Pharmacokinetics of alemtuzumab after haploidentical HLA-mismatched hematopoietic stem cell transplantation using in vivo alemtuzumab with or without CD52-positive malignancies
    Kumi Oshima
    Department of Hematology, Cell Therapy and Transplantation Medicine, University of Tokyo Graduate School of Medicine and Hospital, Tokyo, Japan
    Am J Hematol 81:875-9. 2006
    ....
  15. doi request reprint Oncogenic mutations of ALK kinase in neuroblastoma
    Yuyan Chen
    Department of Pediatrics, Graduate School of Medicine, The University of Tokyo, Tokyo 113 8655, Japan
    Nature 455:971-4. 2008
    ..We anticipate that our findings will provide new insights into the pathogenesis of advanced neuroblastoma and that ALK-specific kinase inhibitors might improve its clinical outcome...
  16. pmc High-risk HLA alleles for severe acute graft-versus-host disease and mortality in unrelated donor bone marrow transplantation
    Satoko Morishima
    Department of Hematology, Fujita Health University School of Medicine, Toyoake, Aichi, Tokyo, Japan
    Haematologica 101:491-8. 2016
    ....
  17. doi request reprint Both Notch1 and Notch2 contribute to the regulation of melanocyte homeostasis
    Keiki Kumano
    Department of Cell Therapy and Transplantation Medicine, University of Tokyo Hospital, Tokyo, Japan
    Pigment Cell Melanoma Res 21:70-8. 2008
    ..Furthermore, Notch1 and Notch2 cooperates with c-kit signaling during embryogenesis, and they cooperate with each other to regulate melanocyte homeostasis after birth...
  18. ncbi request reprint Oligomerization of Evi-1 regulated by the PR domain contributes to recruitment of corepressor CtBP
    Eriko Nitta
    Department of Hematology and Oncology, Graduate School of Medicine, University of Tokyo, Tokyo 113 8655, Japan
    Oncogene 24:6165-73. 2005
    ..These results suggest that oligomerization may contribute to the oncogenic potential of Evi-1-containing proteins...
  19. ncbi request reprint The transcriptionally active form of AML1 is required for hematopoietic rescue of the AML1-deficient embryonic para-aortic splanchnopleural (P-Sp) region
    Susumu Goyama
    Department of Hematology and Oncology, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Blood 104:3558-64. 2004
    ..Thus, this experimental system will become a valuable tool to analyze the physiologic function and domain contribution of Runx proteins in hematopoiesis...
  20. ncbi request reprint Expression profiling of immature thymocytes revealed a novel homeobox gene that regulates double-negative thymocyte development
    Masahito Kawazu
    Department of Hematology and Oncology, University of Tokyo, Japan
    J Immunol 179:5335-45. 2007
    ....
  21. doi request reprint Prognostic significance of genetic alterations detected by high-density single nucleotide polymorphism array in gastric cancer
    Motohisa Tada
    Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Cancer Sci 101:1261-9. 2010
    ..Using high-density SNP arrays, we identified several novel and minute genomic alterations. LOH of four genes could be useful for prediction of lymph node metastasis and prognosis in early stage gastric cancers...
  22. doi request reprint Crk-associated substrate lymphocyte type regulates myeloid cell motility and suppresses the progression of leukemia induced by p210Bcr/Abl
    Sachiko Seo
    Department of Hematology and Oncology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Cancer Sci 102:2109-17. 2011
    ..Thus, Cas-L seems to regulate the progression of CML in a negative way, presumably by attenuating extramedullary hyperplasia...
  23. doi request reprint Gain-of-function of mutated C-CBL tumour suppressor in myeloid neoplasms
    Masashi Sanada
    Cancer Genomics Project, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Nature 460:904-8. 2009
    ..Our findings provide a new insight into a role of gain-of-function mutations of a tumour suppressor associated with aUPD in the pathogenesis of some myeloid cancer subsets...
  24. doi request reprint Biallelic DICER1 mutations in sporadic pleuropulmonary blastoma
    Masafumi Seki
    Authors Affiliations Department of Pediatrics Cancer Genomics Project, Graduate School of Medicine Laboratory of DNA Information Analysis and Sequence Data Analysis, Human Genome Center, Institute of Medical Science Department of Cell Therapy and Transplantation Medicine, The University of Tokyo, Tokyo Department of Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University, Kyoto Division of Pediatric Hematology and Oncology, Ibaraki Children s Hospital, Mito, Ibaraki Department of Hematology Oncology, Saitama Children s Medical Center, Saitama, Saitama Department of Pediatrics, School of Medicine, Fukuoka University, Fukuoka Gunma Children s Medical Center, Shibukawa, Gunma Department of Hematology and Oncology, Hyogo Prefectural Kobe Children s Hospital, Kobe, Hyogo and National Center for Child Health and Development, Tokyo, Japan
    Cancer Res 74:2742-9. 2014
    ..Our results highlight the role of RNase IIIb domain mutations in DICER1 along with TP53 inactivation in PPB pathogenesis...
  25. doi request reprint Derivation of functional mature neutrophils from human embryonic stem cells
    Yasuhisa Yokoyama
    Department of Cell Therapy and Transplantation Medicine, University of Tokyo Hospital, Tokyo, Japan
    Blood 113:6584-92. 2009
    ..Thus, this is the first description of a detailed functional analysis of mature hESC-derived neutrophils...
  26. ncbi request reprint AML1/Runx1 rescues Notch1-null mutation-induced deficiency of para-aortic splanchnopleural hematopoiesis
    Masahiro Nakagawa
    Department of Hematology and Oncology, Graduate School of Medicine, University of Tokyo, Japan
    Blood 108:3329-34. 2006
    ..Our findings also suggest that Notch signaling may modulate both expression and transcriptional activity of Runx1...
  27. ncbi request reprint AML1/Runx1 negatively regulates quiescent hematopoietic stem cells in adult hematopoiesis
    Motoshi Ichikawa
    Department of Hematology and Oncology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    J Immunol 180:4402-8. 2008
    ..We also found an increase in HSC number within the AML1-deficient bone marrow using limiting dilution bone marrow transplantation assays. These results indicate that the number of quiescent HSCs is negatively regulated by AML1...
  28. doi request reprint Notch activation induces the generation of functional NK cells from human cord blood CD34-positive cells devoid of IL-15
    Kyoko Haraguchi
    Department of Cell Therapy and Transplantation Medicine, University of Tokyo Hospital, Tokyo, Japan
    J Immunol 182:6168-78. 2009
    ..Together, these results suggest that Notch signaling is important for the physiologic development of NK cells at differentiation stages beyond those previously postulated...
  29. ncbi request reprint CD1d expression level in tumor cells is an important determinant for anti-tumor immunity by natural killer T cells
    Kyoko Haraguchi
    Department of Hematology Oncology, University of Tokyo Graduate School of Medicine and Hospital, Hongo, Tokyo, Japan
    Leuk Lymphoma 47:2218-23. 2006
    ..These observations possibly suggest that direct cytotoxicity of tumor cells by iNKT cells is common to both humans and mice, and that the high expression level of CD1d may be a predictor whether the tumor is a good target of iNKT cells...
  30. ncbi request reprint Hematopoietic stem cells expanded by fibroblast growth factor-1 are excellent targets for retrovirus-mediated gene delivery
    Aleksandra Crcareva
    Department of Hematology Oncology, University of Tokyo, Japan
    Exp Hematol 33:1459-69. 2005
    ..The objective of this study is to examine whether the use of fibroblast growth factor-1 (FGF-1)-expanded bone marrow cells provide an improved source for retroviral gene delivery to HSCs...
  31. doi request reprint Whole-genome profiling of chromosomal aberrations in hepatoblastoma using high-density single-nucleotide polymorphism genotyping microarrays
    Makoto Suzuki
    Department of General Surgical Science, Graduate School of Medicine, Gunma University Graduate School, 3 39 15 Showa, Maebashi, Gunma, Japan
    Cancer Sci 99:564-70. 2008
    ..The expression patterns of IGF2 and H19 were opposite between genes with and without the UPD. This difference in the expression patterns might influence the clinical features of HBL...
  32. pmc Genome-wide approach to identify second gene targets for malignant rhabdoid tumors using high-density oligonucleotide microarrays
    Junko Takita
    Department of Pediatrics, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Cancer Sci 105:258-64. 2014
    ..These results demonstrated that CNTNAP2 is one of the additional gene targets, other than SMARCB1, in MRT. ..
  33. ncbi request reprint Crk-associated substrate lymphocyte type is required for lymphocyte trafficking and marginal zone B cell maintenance
    Sachiko Seo
    Department of Hematology and Oncology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    J Immunol 175:3492-501. 2005
    ..Thus, Cas-L affects homeostasis of MZB cells and peripheral lymphoid organs, which is considered to be relevant to impaired lymphocyte migration and adhesion...
  34. ncbi request reprint AML-1 is required for megakaryocytic maturation and lymphocytic differentiation, but not for maintenance of hematopoietic stem cells in adult hematopoiesis
    Motoshi Ichikawa
    Department of Hematology and Oncology, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, 113 8655, Japan
    Nat Med 10:299-304. 2004
    ..AML-1 is thus required for maturation of megakaryocytes and differentiation of T and B cells, but not for maintenance of hematopoietic stem cells (HSCs) in adult hematopoiesis...
  35. ncbi request reprint Notch1 oncoprotein antagonizes TGF-beta/Smad-mediated cell growth suppression via sequestration of coactivator p300
    Shigeo Masuda
    Department of Hematology, Graduate School of Medicine, University of Tokyo, Bunkyo ku, Tokyo 113 8655, Japan
    Cancer Sci 96:274-82. 2005
    ..Taken together, we propose that Notch oncoproteins promote cell growth and cancer development partly by suppressing the growth inhibitory effects of TGF-beta through sequestrating p300 from Smad3...
  36. doi request reprint Characterization of genetic lesions in rhabdomyosarcoma using a high-density single nucleotide polymorphism array
    Riki Nishimura
    Department of Pediatrics, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Cancer Sci 104:856-64. 2013
    ..These findings enhance our understanding of the genetic mechanisms underlying RMS pathogenesis and support further studies for therapeutic development of RMS. ..
  37. ncbi request reprint Highly efficient ex vivo expansion of human hematopoietic stem cells using Delta1-Fc chimeric protein
    Takahiro Suzuki
    Department of Regeneration Medicine for Hematopoiesis, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Stem Cells 24:2456-65. 2006
    ..Interestingly, the CD133-sorted cells contained approximately 4.5 times more SRCs than the CD34-sorted cells. The present study provides a promising method to expand HSCs and encourages future trials on clinical transplantation...
  38. pmc An empirical Bayesian framework for somatic mutation detection from cancer genome sequencing data
    Yuichi Shiraishi
    Laboratory of DNA Information Analysis, Human Genome Center, Institute of Medical Science, The University of Tokyo, 4 6 1, Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Nucleic Acids Res 41:e89. 2013
    ....
  39. ncbi request reprint Gain-of-function mutations and copy number increases of Notch2 in diffuse large B-cell lymphoma
    Suk young Lee
    Department of Cell Therapy and Transplantation Medicine, University of Tokyo Hospital, Tokyo 113 8655, Japan
    Cancer Sci 100:920-6. 2009
    ..These findings implicate Notch2 gain-of-function mutations in the pathogenesis of a subset of B-cell lymphomas, and suggest broader roles for Notch gene mutations in human cancers...
  40. pmc Coordinated regulation of transcription factors through Notch2 is an important mediator of mast cell fate
    Mamiko Sakata-Yanagimoto
    Department of Cell Therapy and Transplantation Medicine, University of Tokyo Hospital, Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Proc Natl Acad Sci U S A 105:7839-44. 2008
    ..Taken together, signaling through Notch2 determines the fate of myeloid progenitors toward mast cell-producing progenitors, via coordinately up-regulating Hes-1 and GATA3...
  41. ncbi request reprint Host-residual invariant NK T cells attenuate graft-versus-host immunity
    Kyoko Haraguchi
    Departments of Hematology Oncology, Cell Therapy Transplantation Medicine, University of Tokyo Graduate School of Medicine and Hospital, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    J Immunol 175:1320-8. 2005
    ..These results indicate that host-residual iNKT cells attenuate graft-vs-host immunity rather than host-vs-graft immunity...
  42. pmc Integrated genetic and epigenetic analysis defines novel molecular subgroups in rhabdomyosarcoma
    Masafumi Seki
    Department of Pediatrics, Graduate School of Medicine, The University of Tokyo, Tokyo 113 8655, Japan
    Nat Commun 6:7557. 2015
    ..Despite the better prognosis of embryonal RMS, patients in the E2 are likely to have a poor prognosis. Our results highlight the close relationships of the methylation status and gene mutations with the biological behaviour in RMS. ..
  43. doi request reprint Recurrent somatic mutations underlie corticotropin-independent Cushing's syndrome
    Yusuke Sato
    Department of Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University, Kyoto, Japan Department of Urology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Science 344:917-20. 2014
    ..These results highlight the major role of cAMP-independent activation of cAMP/PKA signaling by somatic mutations in corticotropin-independent Cushing's syndrome, providing insights into the diagnosis and therapeutics of this syndrome. ..
  44. ncbi request reprint A robust algorithm for copy number detection using high-density oligonucleotide single nucleotide polymorphism genotyping arrays
    Yasuhito Nannya
    Department of Hematology Oncology, Graduate School of Medicine, University of Tokyo, Hongo, Tokyo, Japan
    Cancer Res 65:6071-9. 2005
    ....
  45. ncbi request reprint Genomewide screening of DNA copy number changes in chronic myelogenous leukemia with the use of high-resolution array-based comparative genomic hybridization
    Noriko Hosoya
    Department of Hematology and Oncology, Graduate School of Medicine, University of Tokyo, Hongo, Tokyo, Japan
    Genes Chromosomes Cancer 45:482-94. 2006
    ..This article contains Supplementary Material available at http://www.interscience.wiley.com/jpages/1045-2257/suppmat...
  46. ncbi request reprint In vivo alemtuzumab enables haploidentical human leukocyte antigen-mismatched hematopoietic stem-cell transplantation without ex vivo graft manipulation
    Yoshinobu Kanda
    Department of Cell Therapy and Transplantation Medicine, University of Tokyo Hospital, Hongo, Tokyo, Japan
    Transplantation 79:1351-7. 2005
    ..This study evaluates the safety of unmanipulated peripheral blood stem-cell transplantation from two or three loci-mismatched related donors using alemtuzumab in vivo...
  47. doi request reprint Hes1 immortalizes committed progenitors and plays a role in blast crisis transition in chronic myelogenous leukemia
    Fumio Nakahara
    Department of Cell Therapy and Transplantation Medicine, University of Tokyo, Tokyo, Japan
    Blood 115:2872-81. 2010
    ..These results suggest that Hes1 is a key molecule in blast crisis transition in CML...
  48. pmc Deletion of the TNFAIP3/A20 gene detected by FICTION analysis in classical Hodgkin lymphoma
    Junko Nomoto
    Hematology Division, National Cancer Center Hospital, Tokyo, Japan
    BMC Cancer 12:457. 2012
    ..However, the detection of this in primary Hodgkin lymphoma (HL) specimens is hampered by the scarcity of Hodgkin Reed-Sternberg (HR-S) cells even after enrichment by micro-dissection...
  49. ncbi request reprint Runx1/AML-1 ranks as a master regulator of adult hematopoiesis
    Motoshi Ichikawa
    Department of Hematology and Oncology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Cell Cycle 3:722-4. 2004
    ....
  50. doi request reprint Frequent pathway mutations of splicing machinery in myelodysplasia
    Kenichi Yoshida
    Cancer Genomics Project, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Nature 478:64-9. 2011
    ..Our results provide the first evidence indicating that genetic alterations of the major splicing components could be involved in human pathogenesis, also implicating a novel therapeutic possibility for myelodysplasia...
  51. doi request reprint Hepatoblastoma in a patient with sotos syndrome
    Motohiro Kato
    Department of Pediatrics, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    J Pediatr 155:937-9. 2009
    ..Genome-wide analysis of copy number alterations showed a gain of chromosome 2, uniparental disomy of 18q, and microdeletion of 5q35...
  52. doi request reprint Contribution of germline mutations to PARK2 gene inactivation in lung adenocarcinoma
    Reika Iwakawa
    Division of Multistep Carcinogenesis, National Cancer Center Research Institute, Tokyo, Japan
    Genes Chromosomes Cancer 51:462-72. 2012
    ..These results strongly indicate that somatic PARK2 mutations occur rarely (or do not occur) in LADC development and that germline PARK2 mutations could contribute to LADC progression but not to LADC development...
  53. doi request reprint Interstitial deletion of 13q14.13-q32.3 presenting with Arima syndrome and bilateral retinoblastoma
    Kan Takahashi
    Department of Pediatrics, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, Japan
    Brain Dev 33:353-6. 2011
    ..13 to 13q32.3 and involving the RB1 gene. This patient is the first case of Arima syndrome, or a Joubert syndrome-related disorder, that showed linkage to chromosome 13q...
  54. ncbi request reprint Long-term sustained mixed chimerism after allogeneic stem cell transplantation in a patient with severe aplastic anemia
    Akiko M Saito
    Department of Hematology Oncology, Graduate School of Medicine and Department of Cell Therapy Transplantation Medicine, University of Tokyo Hospital, University of Tokyo, Tokyo
    Intern Med 46:1923-6. 2007
    ..This report describes the most comprehensive case study known to date...
  55. ncbi request reprint Immunotherapy against metastatic renal cell carcinoma with mature dendritic cells
    Akihiko Matsumoto
    Department of Urology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Int J Urol 14:277-83. 2007
    ..We performed a clinical trial of immunotherapy using autologous mature dendritic cells (DC) pulsed with autologous tumor lysate, for patients with metastatic renal cell carcinoma (RCC)...
  56. ncbi request reprint Donor killer immunoglobulin-like receptor (KIR) genotype-patient cognate KIR ligand combination and antithymocyte globulin preadministration are critical factors in outcome of HLA-C-KIR ligand-mismatched T cell-replete unrelated bone marrow transplantatio
    Toshio Yabe
    Japanese Red Cross Tokyo Metropolitan Blood Center, Tokyo, Japan
    Biol Blood Marrow Transplant 14:75-87. 2008
    ....
  57. doi request reprint Dual antitumor mechanisms of Notch signaling inhibitor in a T-cell acute lymphoblastic leukemia xenograft model
    Shigeo Masuda
    Department of Cell Therapy and Transplantation Medicine, University of Tokyo Hospital, Tokyo, Japan
    Cancer Sci 100:2444-50. 2009
    ....
  58. pmc Concurrent loss of Ezh2 and Tet2 cooperates in the pathogenesis of myelodysplastic disorders
    Tomoya Muto
    Department of Cellular and Molecular Medicine and 2 Department of Clinical Cell Biology and Medicine, Graduate School of Medicine, Chiba University, Chiba 260 8670, Japan
    J Exp Med 210:2627-39. 2013
    ..Our findings provide the first evidence of the tumor suppressor function of EZH2 in myeloid malignancies and highlight the cooperative effect of concurrent gene mutations in the pathogenesis of myelodysplastic disorders. ..
  59. doi request reprint Adult T-cell leukemia cells are characterized by abnormalities of Helios expression that promote T cell growth
    Satomi Asanuma
    Graduate School of Frontier Sciences, The University of Tokyo, Tokyo, Japan
    Cancer Sci 104:1097-106. 2013
    ..These data provide new insights into the molecular involvement of Helios function in the leukemogenesis and phenotype of ATL cells, indicating that Helios deregulation is one of the novel molecular hallmarks of ATL. ..
  60. doi request reprint Integrated molecular analysis of clear-cell renal cell carcinoma
    Yusuke Sato
    Cancer Genomics Project, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Nat Genet 45:860-7. 2013
    ..This integrated molecular analysis unmasked new correlations between DNA methylation, gene mutation and/or gene expression and copy number profiles, enabling the stratification of clinical risks for patients with ccRCC. ..
  61. doi request reprint Gastric cancer cell line Hs746T harbors a splice site mutation of c-Met causing juxtamembrane domain deletion
    Yoshinari Asaoka
    Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Biochem Biophys Res Commun 394:1042-6. 2010
    ..This information will be useful for screening of inhibitors targeting gastric cancer with c-Met aberration...
  62. doi request reprint Integrated analysis of copy number alterations and loss of heterozygosity in human pancreatic cancer using a high-resolution, single nucleotide polymorphism array
    Lian jie Lin
    Department of Gastroenterology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Oncology 75:102-12. 2008
    ..To chart molecular genetic events in pancreatic cancer...
  63. doi request reprint Genomon ITDetector: a tool for somatic internal tandem duplication detection from cancer genome sequencing data
    Kenichi Chiba
    Laboratory of DNA Information Analysis, Human Genome Center, The Institute of Medical Science, The University of Tokyo, Tokyo 108 8639 and Department of Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University, Kyoto 606 8501, Japan
    Bioinformatics 31:116-8. 2015
    ..Availability and implementaion: Genomon ITDetector is freely available at https://github.com/ken0-1n/Genomon-ITDetector...
  64. doi request reprint Recurrent mutations in multiple components of the cohesin complex in myeloid neoplasms
    Ayana Kon
    Cancer Genomics Project, Graduate School of Medicine, The University of Tokyo, Bunkyo ku, Tokyo, Japan
    Nat Genet 45:1232-7. 2013
    ..These findings suggest a role for compromised cohesin functions in myeloid leukemogenesis. ..
  65. doi request reprint Frequent inactivation of A20 in B-cell lymphomas
    Motohiro Kato
    Cancer Genomics Project, Department of Pediatrics, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Nature 459:712-6. 2009
    ....
  66. ncbi request reprint Molecular cytogenetic analyses of HIG, a novel human cell line carrying t(1;3)(p36.3;q25.3) established from a patient with chronic myelogenous leukemia in blastic crisis
    Noriko Hosoya
    Department of Hematology and Oncology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Int J Hematol 78:432-8. 2003
    ..Further analyses of the deregulated genes in the HIG cell line should provide important insight into the mechanisms involved in these types of leukemias...
  67. doi request reprint Aberrations of NEGR1 on 1p31 and MYEOV on 11q13 in neuroblastoma
    Junko Takita
    Department of Cell Therapy and Transplantation, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Cancer Sci 102:1645-50. 2011
    ..In addition, the findings suggest a possible prognostic value for NEGR1 in neuroblastoma...
  68. doi request reprint MYC amplification as a prognostic marker of early-stage lung adenocarcinoma identified by whole genome copy number analysis
    Reika Iwakawa
    Biology Division, National Cancer Center Research Institute Cancer Genomics Project, The University of Tokyo, Tokyo, Japan
    Clin Cancer Res 17:1481-9. 2011
    ..The purpose of this study was to identify genetic alterations that define prognosis of patients with early-stage lung ADC...
  69. ncbi request reprint A prospective trial to evaluate the safety and efficacy of pravastatin for the treatment of refractory chronic graft-versus-host disease
    Akiko Hori
    Hematopoietic Stem Cell Transplant Unit, National Cancer Center Hospital, Tokyo, Japan
    Transplantation 79:372-4. 2005
    ..A randomized controlled trial is warranted to evaluate the efficacy of pravastatin against chronic GVHD...
  70. ncbi request reprint Assessment of the international prognostic scoring system for determining chemotherapeutic indications in myelodysplastic syndrome: Japanese retrospective multicenter study
    Yoshikazu Ito
    First Department of Internal Medicine, Tokyo Medical University, 6 7 1 Nishishinjuku, Shinjuku ku, Tokyo, Japan
    Int J Hematol 82:236-42. 2005
    ..Our proposition may be useful for developing a chemotherapeutic strategy for patients with MDS in Japan...
  71. ncbi request reprint Clinical significance of peripheral blood erythroblastosis after hematopoietic stem cell transplantation
    Susumu Goyama
    Department of Cell Therapy and Transplantation Medicine, University of Tokyo, Japan
    Leuk Lymphoma 45:2439-43. 2004
    ..As for post-transplant events, a high EBL concentration was frequently preceded by graft-vs.-host disease, thrombotic microangiopathy, hypoxia, and hematological relapse...
  72. doi request reprint Clonal selection in xenografted TAM recapitulates the evolutionary process of myeloid leukemia in Down syndrome
    Satoshi Saida
    Department of Pediatrics, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Blood 121:4377-87. 2013
    ..Our xenograft model of TAM may provide unique insight into the evolutionary process of leukemia...
  73. doi request reprint KIF5B-RET fusions in lung adenocarcinoma
    Takashi Kohno
    Division of Genome Biology, National Cancer Center Research Institute, Chuo Ku, Tokyo, Japan
    Nat Med 18:375-7. 2012
    ....
  74. doi request reprint Single-nucleotide polymorphism array karyotyping in clinical practice: where, when, and how?
    Aiko Sato-Otsubo
    Cancer Genomics Project, Graduate School of Medicine, The University of Tokyo, Bunkyo ku, Tokyo, Japan
    Semin Oncol 39:13-25. 2012
    ..Here, we review the current status of SNP-A karyotyping and its application to hematopoietic neoplasms...
  75. ncbi request reprint Evaluation of genome-wide power of genetic association studies based on empirical data from the HapMap project
    Yasuhito Nannya
    Department of Hematology Oncology, Graduate School of Medicine, University of Tokyo, Tokyo 113 8655, Japan
    Hum Mol Genet 16:2494-505. 2007
    ..7], we can expect satisfactory power with currently available large-scale genotyping platforms using realistic sample size ( approximately 1000 per arm)...
  76. pmc Prospective comparison of the diagnostic potential of real-time PCR, double-sandwich enzyme-linked immunosorbent assay for galactomannan, and a (1-->3)-beta-D-glucan test in weekly screening for invasive aspergillosis in patients with hematological disord
    Masahito Kawazu
    Department of Hematology and Oncology, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    J Clin Microbiol 42:2733-41. 2004
    ..In conclusion, among these weekly screening tests for IA, the double-sandwich ELISA test was the most sensitive at predicting the diagnosis of IA in high-risk patients with hematological disorders, using a reduced cutoff of 0.6 O.D.I...
  77. ncbi request reprint Genome-wide analysis of myelodysplastic syndromes
    Masashi Sanada
    Cancer Genomics Project, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Curr Pharm Des 18:3163-9. 2012
    ..In this review, we briefly overview the recent progress in the genetics of MDS, focusing on the newly identified gene targets in MDS...
  78. doi request reprint Extensive gene deletions in Japanese patients with Diamond-Blackfan anemia
    Madoka Kuramitsu
    Department of Safety Research on Blood and Biological Products, National Institute of Infectious Diseases, Tokyo, Japan
    Blood 119:2376-84. 2012
    ..Our data suggest that large deletions in RP genes comprise a sizable fraction of DBA patients in Japan. In addition, our novel approach may become a useful tool for screening gene copy numbers of known DBA genes...
  79. doi request reprint Polycomb-mediated loss of miR-31 activates NIK-dependent NF-κB pathway in adult T cell leukemia and other cancers
    Makoto Yamagishi
    Graduate School of Frontier Sciences, The University of Tokyo, Japan
    Cancer Cell 21:121-35. 2012
    ..Furthermore, this emerging circuit operates in other cancers and receptor-initiated NF-κB cascade. Our findings provide a perspective involving the epigenetic program, inflammatory responses, and oncogenic signaling...
  80. ncbi request reprint Graft-versus-tumor effect against advanced pancreatic cancer after allogeneic reduced-intensity stem cell transplantation
    Yoshinobu Kanda
    Department of Cell Therapy and Transplantation Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Transplantation 79:821-7. 2005
    ....
  81. ncbi request reprint Molecular characterization of the recurrent unbalanced translocation der(1;7)(q10;p10)
    Lili Wang
    Department of Hematology and Oncology, Graduate School of Medicine, University of Tokyo, Japan
    Blood 102:2597-604. 2003
    ..Our results provide a novel insight into the structural basis for generation of this translocation as well as its leukemogenic roles...
  82. ncbi request reprint Immature granulocyte fraction in the peripheral blood is a practical indicator for mobilization of CD34(+) cells
    Mari Endo-Matsubara
    Departments of Cell Therapy Transplantation Medicine and Hematology Oncology, University of Tokyo Hospital and Graduate School of Medicine, Tokyo, Japan
    Am J Hematol 77:223-8. 2004
    ..These findings indicate that LSI is a useful and simple method for predicting the yield of CD34(+) cells before the start of PBSC collection and avoiding unnecessary apheresis...
  83. ncbi request reprint Rapid diagnosis of invasive pulmonary aspergillosis by quantitative polymerase chain reaction using bronchial lavage fluid
    Masahito Kawazu
    Department of Hematology and Oncology, University of Tokyo, Tokyo, Japan
    Am J Hematol 72:27-30. 2003
    ..This novel tool will provide rapid, sensitive, and specific diagnosis of pulmonary aspergillosis...
  84. ncbi request reprint Influence of glutathione S-transferase A1 polymorphism on the pharmacokinetics of busulfan
    Makiko Kusama
    Department of Pharmacy, University of Tokyo Hospital University of Tokyo, 7 3 1 Hongo, Bunkyo ku Tokyo, 113 8655, Japan
    Clin Chim Acta 368:93-8. 2006
    ..Glutathione S-transferase (GST) A1, whose genetic polymorphism in its promoter region has been reported, is responsible for busulfan metabolism. We investigated the polymorphism of GSTA1 on busulfan pharmacokinetics...
  85. ncbi request reprint Notch1 but not Notch2 is essential for generating hematopoietic stem cells from endothelial cells
    Keiki Kumano
    Department of Hematology and Oncology, Graduate School of Medicine, University of Tokyo, Japan
    Immunity 18:699-711. 2003
    ..In contrast, Notch2(-/-) embryos showed no hematopoietic deficiency. These data indicate that Notch1, but not Notch2, is essential for generating hematopoietic stem cells from endothelial cells...
  86. ncbi request reprint Generation of Fas-independent CD4+ cytotoxic T-cell clone specific for p190 minor bcr-abl fusion peptide
    Yuji Tanaka
    Department of Hematology and Oncology, Graduate School of Medicine, University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo 113 8655, Japan
    Leuk Res 26:317-21. 2002
    ..Success in establishment of the p190 bcr-abl fusion peptide-specific T-cell clone encourages us to develop a new approach to an effective immunotherapy for Ph+ALL...
  87. ncbi request reprint Mutational analyses of the AML1 gene in patients with myelodysplastic syndrome
    Oich Imai
    Department of Hematology and Oncology, Graduate School of Medicine, University of Tokyo, Japan
    Leuk Lymphoma 43:617-21. 2002
    ..In this review, we summarize mutational changes of the AML1 gene in hematological malignancies, especially in MDS and discuss the mechanism whereby the mutant acts as a dominant negative inhibitor of wild-type AML1...