Katsutoshi Oda

Summary

Affiliation: University of Tokyo
Country: Japan

Publications

  1. pmc Huge pyogenic cervical cyst with endometriosis, developing 13 years after myomectomy at the lower uterine segment: a case report
    Katsutoshi Oda
    Department of Obstetrics and Gynecology, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    BMC Womens Health 14:104. 2014
  2. pmc Xanthogranulomatous inflammation of the perimetrium with infiltration into the uterine myometrium in a postmenopausal woman: a case report
    Tomoko Inoue
    Department of Obstetrics and Gynecology, Faculty of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    BMC Womens Health 14:82. 2014
  3. pmc The oncogenic mutation in the pleckstrin homology domain of AKT1 in endometrial carcinomas
    K Shoji
    Department of Obstetrics and Gynecology, The University of Tokyo, Tokyo, Japan
    Br J Cancer 101:145-8. 2009
  4. pmc Anti-tumor activity of olaparib, a poly (ADP-ribose) polymerase (PARP) inhibitor, in cultured endometrial carcinoma cells
    Aki Miyasaka
    Department of Obstetrics and Gynecology, Faculty of Medicine, The University of Tokyo, 7 3 1 Hongo Bunkyo ku, Tokyo 113 8655, Japan
    BMC Cancer 14:179. 2014
  5. ncbi request reprint Cytodiagnostic problems in uterine sarcoma. Analysis according to a novel classification of tumor growth types
    Katsutoshi Oda
    Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Acta Cytol 48:181-6. 2004
  6. doi request reprint PIK3CA cooperates with other phosphatidylinositol 3'-kinase pathway mutations to effect oncogenic transformation
    Katsutoshi Oda
    Cancer Research Institute, Howard Hughes Medical Institute, University of California at San Francisco, San Francisco, California, USA
    Cancer Res 68:8127-36. 2008
  7. pmc Genotype-dependent efficacy of a dual PI3K/mTOR inhibitor, NVP-BEZ235, and an mTOR inhibitor, RAD001, in endometrial carcinomas
    Keiko Shoji
    Department of Obstetrics and Gynecology, Faculty of Medicine, The University of Tokyo, Tokyo, Japan
    PLoS ONE 7:e37431. 2012
  8. doi request reprint Sequential effects of the proteasome inhibitor bortezomib and chemotherapeutic agents in uterine cervical cancer cell lines
    Yuichiro Miyamoto
    Department of Obstetrics and Gynecology, Graduate School of Medicine, The University of Tokyo, Tokyo 113 8655, Japan
    Oncol Rep 29:51-7. 2013
  9. doi request reprint Genome-wide single nucleotide polymorphism arrays as a diagnostic tool in patients with synchronous endometrial and ovarian cancer
    Yuji Ikeda
    Department of Obstetrics and Gynecology, Faculty of Medicine, The University of Tokyo, Tokyo, Japan
    Int J Gynecol Cancer 22:725-31. 2012
  10. doi request reprint Cyclin D1 harboring the T286I mutation promotes oncogenic activation in endometrial cancer
    Yuji Ikeda
    Department of Obstetrics and Gynecology, Faculty of Medicine, The University of Tokyo, Tokyo 113 8655, Japan
    Oncol Rep 30:584-8. 2013

Detail Information

Publications81

  1. pmc Huge pyogenic cervical cyst with endometriosis, developing 13 years after myomectomy at the lower uterine segment: a case report
    Katsutoshi Oda
    Department of Obstetrics and Gynecology, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    BMC Womens Health 14:104. 2014
    ..These infections usually develop immediately after the surgery, and are most often located in the myometrium. Pyogenic cervical cysts are rare and have not been previously reported to occur at the site of myomectomy...
  2. pmc Xanthogranulomatous inflammation of the perimetrium with infiltration into the uterine myometrium in a postmenopausal woman: a case report
    Tomoko Inoue
    Department of Obstetrics and Gynecology, Faculty of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    BMC Womens Health 14:82. 2014
    ....
  3. pmc The oncogenic mutation in the pleckstrin homology domain of AKT1 in endometrial carcinomas
    K Shoji
    Department of Obstetrics and Gynecology, The University of Tokyo, Tokyo, Japan
    Br J Cancer 101:145-8. 2009
    ..The AKT1 (E17K) mutation has been reported in some tumour types (breast, colorectal, ovarian and lung cancers), and it is of interest which tumour types other than those possess the E17K mutation...
  4. pmc Anti-tumor activity of olaparib, a poly (ADP-ribose) polymerase (PARP) inhibitor, in cultured endometrial carcinoma cells
    Aki Miyasaka
    Department of Obstetrics and Gynecology, Faculty of Medicine, The University of Tokyo, 7 3 1 Hongo Bunkyo ku, Tokyo 113 8655, Japan
    BMC Cancer 14:179. 2014
    ..We examined the anti-tumor activity of olaparib, a PARP inhibitor, and its correlation between the sensitivity and status of PTEN in endometrial cancer cell lines...
  5. ncbi request reprint Cytodiagnostic problems in uterine sarcoma. Analysis according to a novel classification of tumor growth types
    Katsutoshi Oda
    Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Acta Cytol 48:181-6. 2004
    ..To clarify the cytologic diagnostic problems of uterine sarcomas and the differential properties between pure sarcomas and carcinosarcomas...
  6. doi request reprint PIK3CA cooperates with other phosphatidylinositol 3'-kinase pathway mutations to effect oncogenic transformation
    Katsutoshi Oda
    Cancer Research Institute, Howard Hughes Medical Institute, University of California at San Francisco, San Francisco, California, USA
    Cancer Res 68:8127-36. 2008
    ..Our data therefore suggest that in tumors with co-occurring mutations in multiple components of the PI3K pathway, selective inhibition of the alpha isoform of p110 is an attractive therapeutic strategy, especially for late-stage tumors...
  7. pmc Genotype-dependent efficacy of a dual PI3K/mTOR inhibitor, NVP-BEZ235, and an mTOR inhibitor, RAD001, in endometrial carcinomas
    Keiko Shoji
    Department of Obstetrics and Gynecology, Faculty of Medicine, The University of Tokyo, Tokyo, Japan
    PLoS ONE 7:e37431. 2012
    ..Our data suggest that mutational statuses of PTEN and K-Ras might be useful predictors of sensitivity to NVP-BEZ235 in certain endometrial carcinomas...
  8. doi request reprint Sequential effects of the proteasome inhibitor bortezomib and chemotherapeutic agents in uterine cervical cancer cell lines
    Yuichiro Miyamoto
    Department of Obstetrics and Gynecology, Graduate School of Medicine, The University of Tokyo, Tokyo 113 8655, Japan
    Oncol Rep 29:51-7. 2013
    ....
  9. doi request reprint Genome-wide single nucleotide polymorphism arrays as a diagnostic tool in patients with synchronous endometrial and ovarian cancer
    Yuji Ikeda
    Department of Obstetrics and Gynecology, Faculty of Medicine, The University of Tokyo, Tokyo, Japan
    Int J Gynecol Cancer 22:725-31. 2012
    ..Although the prognosis of DP without any metastases is significantly better than that of SPM, pathological diagnosis is difficult in tumors with similar histological features...
  10. doi request reprint Cyclin D1 harboring the T286I mutation promotes oncogenic activation in endometrial cancer
    Yuji Ikeda
    Department of Obstetrics and Gynecology, Faculty of Medicine, The University of Tokyo, Tokyo 113 8655, Japan
    Oncol Rep 30:584-8. 2013
    ..In conclusion, we identified an unreported CCND1 mutation (T286I) in two endometrial cancers and revealed that the mutation was functional for inducing cell proliferation in human cells...
  11. doi request reprint hScrib, a human homologue of Drosophila neoplastic tumor suppressor, is a novel death substrate targeted by caspase during the process of apoptosis
    Kenbun Sone
    Department of Obstetrics and Gynecology, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Genes Cells 13:771-85. 2008
    ..These results indicate that caspase-dependent cleavage of hScrib is a critical step for detachment of cell contact during the process of apoptosis...
  12. doi request reprint CCAR2 negatively regulates nuclear receptor LXRα by competing with SIRT1 deacetylase
    Ayako Sakurabashi
    Department of Obstetrics and Gynecology, Graduate School of Medicine, The University of Tokyo, Hongo 7 3 1 Bunkyo ku, Tokyo 113 8655, Japan
    J Steroid Biochem Mol Biol 149:80-8. 2015
    ..Therefore, these results clearly indicate a novel mechanism in which CCAR2 may regulate the transcriptional activation function of LXRα due to its specific inhibition of SIRT1 and serve to regulate cellular proliferation. ..
  13. doi request reprint Regulation of SIRT1 determines initial step of endometrial receptivity by controlling E-cadherin expression
    Akira Shirane
    Department of Obstetrics and Gynecology, Graduate School of Medicine, The University of Tokyo, Hongo 7 3 1 Bunkyo ku, Tokyo 113 8655, Japan
    Biochem Biophys Res Commun 424:604-10. 2012
    ....
  14. doi request reprint Low-grade endometrial stromal sarcoma developing in a postmenopausal woman under toremifene treatment for breast cancer
    Tomoko Kashiyama
    Departments of Obstetrics and Gynecology Pathology, The University of Tokyo, Tokyo, Japan
    J Obstet Gynaecol Res 39:424-9. 2013
    ..The patient discontinued toremifene and has been progression-free for 21 months. Our data suggest that toremifene might be associated with the development of ESS in certain patients through its estrogen-like effects in the uterus...
  15. doi request reprint Retreatment with nedaplatin in patients with recurrent gynecological cancer after the development of hypersensitivity reaction to carboplatin
    Takahide Arimoto
    Department of Obstetrics and Gynecology, Faculty of Medicine, The University of Tokyo, Tokyo, Japan
    J Obstet Gynaecol Res 39:336-40. 2013
    ..The purpose of this retrospective study was to investigate the feasibility of replacing carboplatin with nedaplatin in patients who had developed a hypersensitivity reaction to carboplatin...
  16. pmc Measurement of endometrial thickness by transvaginal ultrasonography to predict pathological response to medroxyprogesterone acetate in patients with grade 1 endometrioid adenocarcinoma
    Masakazu Sato
    Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo, Tokyo 1138655, Japan
    Mol Clin Oncol 4:492-496. 2016
    ..Measurement of endometrial thickness during MPA treatment may be useful as a predictive marker for pathological response to MPA in patients with EmCa, G1...
  17. pmc Expression of Par3 polarity protein correlates with poor prognosis in ovarian cancer
    Hiroe Nakamura
    Department of Obstetrics and Gynecology, Faculty of Medicine, The University of Tokyo, Tokyo, 113 8655, Japan
    BMC Cancer 16:897. 2016
    ..Aberrant function of this protein has been reported to be involved in epithelial-mesenchymal transition (EMT) and cancer invasion. The aim of this study was to examine the functional mechanism of Par3 in ovarian cancer...
  18. pmc Modification of the Tumor Microenvironment in KRAS or c-MYC-Induced Ovarian Cancer-Associated Peritonitis
    Mitsuyo Yoshida
    Department of Obstetrics and Gynecology, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    PLoS ONE 11:e0160330. 2016
    ..These results suggest that oncogenes promote cancer progression by modulating the TME in favor of cancer progression. ..
  19. pmc Autophagy inhibition augments resveratrol-induced apoptosis in Ishikawa endometrial cancer cells
    Tomohiko Fukuda
    Department of Obstetrics and Gynecology, Graduate School of Medicine, The University of Tokyo, Tokyo 113 8655, Japan
    Oncol Lett 12:2560-2566. 2016
    ..Combination treatment with RSV and an autophagy inhibitor, such as CQ, may be an attractive therapeutic option for treating certain endometrial cancer cells...
  20. doi request reprint HAND2-mediated proteolysis negatively regulates the function of estrogen receptor α
    Tomohiko Fukuda
    Department of Obstetrics and Gynecology, Graduate School of Medicine, The University of Tokyo, Tokyo 113 8655, Japan
    Mol Med Rep 12:5538-44. 2015
    ..Considering that HAND2 is commonly hypermethylated and silenced in endometrial cancer, it is hypothesized that HAND2 may serve as a possible tumor suppressor, particularly in uterine tissue...
  21. doi request reprint Radical hysterectomy with or without para-aortic lymphadenectomy for patients with stage IB2, IIA2, and IIB cervical cancer: outcomes for a series of 308 patients
    Tetsushi Tsuruga
    Department of Obstetrics and Gynecology, Faculty of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, 113 8655, Japan
    Int J Clin Oncol 21:359-66. 2016
    ....
  22. doi request reprint Characterization of TP53 and PI3K signaling pathways as molecular targets in gynecologic malignancies
    Katsutoshi Oda
    Department of Obstetrics and Gynecology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    J Obstet Gynaecol Res 42:757-62. 2016
    ....
  23. pmc Spheroid cancer stem cells display reprogrammed metabolism and obtain energy by actively running the tricarboxylic acid (TCA) cycle
    Masakazu Sato
    Department of Obstetrics and Gynecology, Graduate School of Medicine, The University of Tokyo, Bunkyo ku, Tokyo, Japan
    Oncotarget 7:33297-305. 2016
    ..The amino acid metabolic pathways discussed here are already considered as targets for cancer therapy, and they are additionally proposed as potential targets for CSC treatment. ..
  24. doi request reprint Decreased expression of the plasminogen activator inhibitor type 1 is involved in degradation of extracellular matrix surrounding cervical cancer stem cells
    Masakazu Sato
    Department of Obstetrics and Gynecology, Graduate School of Medicine, The University of Tokyo, Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Int J Oncol 48:829-35. 2016
    ..Our study could be an explanation of conflicting reports, where some researchers found negative impacts of PAI-1 expression on clinical outcomes and others not, by considering the concept of CSCs...
  25. doi request reprint The anti-malarial chloroquine suppresses proliferation and overcomes cisplatin resistance of endometrial cancer cells via autophagy inhibition
    Tomohiko Fukuda
    Department of Obstetrics and Gynecology, Graduate School of Medicine, The University of Tokyo, Hongo 7 3 1 Bunkyo ku, Tokyo 113 8655, Japan
    Gynecol Oncol 137:538-45. 2015
    ..However, the role of autophagy in endometrial cancer has not yet been established. We investigated the anti-tumor effects and autophagy inhibition caused by CQ in endometrial cancer cells...
  26. doi request reprint PI3K/mTOR pathway inhibition overcomes radioresistance via suppression of the HIF1-α/VEGF pathway in endometrial cancer
    Aki Miyasaka
    Department of Obstetrics and Gynaecology, Faculty of Medicine, The University of Tokyo, 7 3 1 Hongo Bunkyo ku, Tokyo 113 8655, Japan
    Gynecol Oncol 138:174-80. 2015
    ..Our study data suggest that TP53 mutation and PI3K pathway activation enhances radioresistance in endometrial carcinomas and that targeting the PI3K/mTOR or HIF-1α pathways could improve radiosensitivity...
  27. doi request reprint Putative tumor suppression function of SIRT6 in endometrial cancer
    Tomohiko Fukuda
    Department of Obstetrics and Gynecology, Graduate School of Medicine, The University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo 113 8655, Japan
    FEBS Lett 589:2274-81. 2015
    ..Consistent with this result, a survivin inhibitor YM155 efficiently inhibited cellular proliferation and induced apoptosis. These results revealed that SIRT6 might function as a tumor suppressor of endometrial cancer cells. ..
  28. doi request reprint Positive peritoneal cytology at interval surgery is a poor prognostic factor in patients with stage T3c advanced ovarian carcinoma: A retrospective study
    Kazunori Nagasaka
    Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    J Obstet Gynaecol Res 41:755-62. 2015
    ....
  29. doi request reprint Oral vaccination against HPV E7 for treatment of cervical intraepithelial neoplasia grade 3 (CIN3) elicits E7-specific mucosal immunity in the cervix of CIN3 patients
    Kei Kawana
    Department of Obstetrics and Gynecology, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan Electronic address
    Vaccine 32:6233-9. 2014
    ..Induction of immunological clearance of CIN3 by targeting HPV antigens is a promising strategy for CIN3 therapy. No successful HPV therapeutic vaccine has been developed...
  30. doi request reprint The prevalence of cervical regulatory T cells in HPV-related cervical intraepithelial neoplasia (CIN) correlates inversely with spontaneous regression of CIN
    Satoko Kojima
    Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo, Bunkyo ku, Tokyo, Japan
    Am J Reprod Immunol 69:134-41. 2013
    ..PD-1 expression on T cells induces Tregs. No studies have quantitatively analyzed the Tregs and PD-1+ cells residing in CIN lesions...
  31. doi request reprint Repression of estrogen receptor beta function by putative tumor suppressor DBC1
    Satoshi Koyama
    Department of Obstetrics and Gynecology, The University of Tokyo, Tokyo 113 8655, Japan
    Biochem Biophys Res Commun 392:357-62. 2010
    ..These results implicate the principal role of DBC1 in regulating ERbeta-dependent gene expressions...
  32. doi request reprint Low uptake of fluorodeoxyglucose in positron emission tomography/computed tomography in ovarian clear cell carcinoma may reflect glutaminolysis of its cancer stem cell-like properties
    Masakazu Sato
    Department of Obstetrics and Gynecology, Graduate School of Medicine, The University of Tokyo, Bunkyo ku, Tokyo 113 0033, Japan
    Oncol Rep . 2017
    ..The phosphorylation level of AMPK was reduced in CSCs compared to non-CSCs. In conclusion, we suggested that ovarian CCC showed low activation of glycolysis, and this may reflect glutaminolysis of its CSC-like properties...
  33. pmc Synergistic antitumor effects of combination PI3K/mTOR and MEK inhibition (SAR245409 and pimasertib) in mucinous ovarian carcinoma cells by fluorescence resonance energy transfer imaging
    Kanako Inaba
    Department of Obstetrics and Gynecology, Faculty of Medicine, The University of Tokyo, Tokyo, Japan
    Oncotarget 7:29577-91. 2016
    ....
  34. pmc Inhibition of endoplasmic reticulum (ER) stress sensors sensitizes cancer stem-like cells to ER stress-mediated apoptosis
    Asaha Fujimoto
    Department of Obstetrics and Gynecology, Graduate School of Medicine, The University of Tokyo, Tokyo 113 8655, Japan
    Oncotarget . 2016
    ..The results of the present study demonstrated that the inhibition of ER stress sensors, combined with ER stress-inducible chemotherapy, shifted cancer stem-like cells to ER stress-mediated apoptosis...
  35. ncbi request reprint The Emerging Role of FOXL2 in Regulating the Transcriptional Activation Function of Estrogen Receptor β: An Insight Into Ovarian Folliculogenesis
    Mana Hirano
    Department of Obstetrics and Gynecology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Reprod Sci . 2016
    ....
  36. doi request reprint STAT3 activity regulates sensitivity to tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in cervical cancer cells
    Hiroe Nakamura
    Department of Obstetrics and Gynecology, Graduate School of Medicine, The University of Tokyo, Bunkyo ku, Tokyo 113 8655, Japan
    Int J Oncol 49:2155-2162. 2016
    ..Our results also suggest that STAT3 inhibition increases the sensitivity of malignancies, particularly HPV-related cancer, to TRAIL-based therapy...
  37. pmc Cancer-associated fibroblast suppresses killing activity of natural killer cells through downregulation of poliovirus receptor (PVR/CD155), a ligand of activating NK receptor
    Tomoko Inoue
    Department of Obstetrics and Gynecology, Faculty of Medicine, The University of Tokyo, Bunkyo ku, Tokyo 113 8655, Japan
    Int J Oncol 49:1297-304. 2016
    ..This study demonstrated a novel mechanism of suppression of NK cell activity by CAFs in the TME. ..
  38. pmc Prognostic importance of CDK4/6-specific activity as a predictive marker for recurrence in patients with endometrial cancer, with or without adjuvant chemotherapy
    Yuji Ikeda
    Department of Obstetrics and Gynaecology, Faculty of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Br J Cancer 113:1477-83. 2015
    ..We evaluated the clinical importance of cyclin-dependent kinase 4/6 (CDK4/6) activity, and its significance as a novel biomarker for the prognosis and chemo-sensitivity of endometrioid endometrial carcinoma (EEC)...
  39. doi request reprint Antitumor activity of a combination of dual PI3K/mTOR inhibitor SAR245409 and selective MEK1/2 inhibitor pimasertib in endometrial carcinomas
    Kanako Inaba
    Department of Obstetrics and Gynecology, Faculty of Medicine, The University of Tokyo, Japan
    Gynecol Oncol 138:323-31. 2015
    ..We aimed to clarify whether dual inhibition of PI3K/MAPK and MAPK pathways synergistically suppresses cell growth in endometrial cancer cells...
  40. pmc HPV-16 impairs the subcellular distribution and levels of expression of protein phosphatase 1γ in cervical malignancy
    Takayuki Seiki
    Department of Obstetrics and Gynecology, Faculty of Medicine, The University of Tokyo, Tokyo, 113 8655, Japan
    BMC Cancer 15:230. 2015
    ..Important cellular targets of E6 include p53 and the PDZ domain containing substrates such as hScrib and Dlg. We recently showed that hScrib activity was mediated in part through recruitment of protein phosphatase 1γ (PP1γ)...
  41. doi request reprint Aromatase inhibitor anastrozole as a second-line hormonal treatment to a recurrent low-grade endometrial stromal sarcoma: a case report
    Keiko Shoji
    Department of Obstetrics and Gynecology, Faculty of Medicine, The University of Tokyo, 7 3 1 Hongo Bunkyo ku, Tokyo, 113 8655, Japan
    Med Oncol 28:771-4. 2011
    ..Anastrozole was effective to recurrent low-grade ESS even after being refractory to progestin therapy. Aromatase inhibitor treatment may be a useful option as a second-line hormonal treatment to low-grade ESS...
  42. ncbi request reprint Genome-wide cDNA microarray analysis of gene-expression profiles involved in ovarian endometriosis
    Takahide Arimoto
    Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo 108 8639, Japan
    Int J Oncol 22:551-60. 2003
    ..These data should provide useful information for finding candidate genes whose products might serve as molecular targets for diagnosis or treatment of endometriosis...
  43. pmc Omega-3 polyunsaturated Fatty acids suppress the cystic lesion formation of peritoneal endometriosis in transgenic mouse models
    Kensuke Tomio
    Department of Obstetrics and Gynecology, Faculty of Medicine, The University of Tokyo, Tokyo, Japan
    PLoS ONE 8:e73085. 2013
    ....
  44. doi request reprint High-risk human papillomavirus correlates with recurrence after laser ablation for treatment of patients with cervical intraepithelial neoplasia 3: a long-term follow-up retrospective study
    Kanako Inaba
    Department of Obstetrics and Gynecology, Faculty of Medicine, The University of Tokyo, Tokyo, Japan
    J Obstet Gynaecol Res 40:554-60. 2014
    ....
  45. doi request reprint Adjuvant effect of Japanese herbal medicines on the mucosal type 1 immune responses to human papillomavirus (HPV) E7 in mice immunized orally with Lactobacillus-based therapeutic HPV vaccine in a synergistic manner
    Ayumi Taguchi
    Department of Obstetrics and Gynecology, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Vaccine 30:5368-72. 2012
    ....
  46. pmc A case of lymphangioleiomyomatosis associated with endometrial cancer and severe systemic lupus erythematosus
    Kensuke Suzuki
    Department of Obstetrics and Gynecology, Faculty of Medicine, The University of Tokyo, Tokyo, Japan
    BMC Cancer 16:390. 2016
    ..Lymphangioleiomyomatosis (LAM) is a rare idiopathic disorder that occurs in women of childbearing age, and consists of a diffuse proliferation of abnormal smooth muscle cells along the thoracic and abdominal lymphogenous route...
  47. pmc Enhanced efficacy against cervical carcinomas through polymeric micelles physically incorporating the proteasome inhibitor MG132
    Yoko Matsumoto
    Department of Obstetrics and Gynecology, Faculty of Medicine, The University of Tokyo, Tokyo, Japan
    Cancer Sci 107:773-81. 2016
    ..These results support the use of MG132 incorporated into polymeric micelles as a safe and effective therapeutic strategy against cervical tumors. ..
  48. doi request reprint MDM2 is a potential therapeutic target and prognostic factor for ovarian clear cell carcinomas with wild type TP53
    Chinami Makii
    Department of Obstetrics and Gynecology, Graduate School of Medicine, The University of Tokyo, Japan
    Oncotarget . 2016
    ..033), and the density of microvessels (P = 0.011). Our results highlight the prognostic value of MDM2 expression in clear cell carcinoma. Thus, MDM2 inhibitors such as RG7112 may constitute a class of potential therapeutics...
  49. doi request reprint Vaginal cancer possibly caused by pessary and immunocompromised condition: Multiple risk factors may influence vaginal cancer development
    Nana Akino
    Department of Obstetrics and Gynecology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    J Obstet Gynaecol Res 42:748-751. 2016
    ..The presence of multiple risk factors could be related to the pathogenesis of vaginal cancer, and therefore proper management is required after pessary insertion for uterine prolapse treatment...
  50. pmc Integrated copy number and expression analysis identifies profiles of whole-arm chromosomal alterations and subgroups with favorable outcome in ovarian clear cell carcinomas
    Yuriko Uehara
    Genome Science Division, Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo, Japan Department of Obstetrics and Gynecology, The University of Tokyo, Tokyo, Japan
    PLoS ONE 10:e0128066. 2015
    ..As such, expression profiles might be useful for sub-classification of CCC, and might provide useful information on prognosis. ..
  51. doi request reprint Minimization of curative surgery for treatment of early cervical cancer: a review
    Takahide Arimoto
    Department of Obstetrics and Gynecology, Faculty of Medicine, The University of Tokyo, Tokyo
    Jpn J Clin Oncol 45:611-6. 2015
    ..Here, we have summarized and discussed the minimally invasive procedures for the treatment of patients with early cervical cancer. ..
  52. pmc Matrix metalloproteinase (MMP)-9 in cancer-associated fibroblasts (CAFs) is suppressed by omega-3 polyunsaturated fatty acids in vitro and in vivo
    Ayumi Taguchi
    Department of Obstetrics and Gynecology, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, Japan
    PLoS ONE 9:e89605. 2014
    ..Our data suggests that omega-3 PUFAs suppress MMP-9 induction and tumor angiogenesis. These findings may provide insight into mechanisms by which omega-3 PUFAs exert anti-tumor effects by modulating tumor microenvironment. ..
  53. pmc Increased tissue levels of omega-3 polyunsaturated fatty acids prevents pathological preterm birth
    Aki Yamashita
    Department of Obstetrics and Gynecology, Faculty of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Sci Rep 3:3113. 2013
    ..We finally showed that the administration of RvE3 to LPS-exposed pregnant wild type mice lowered the incidence of preterm birth. Our data suggest that RvE3 could be a potential new therapeutic for the prevention of preterm birth. ..
  54. doi request reprint Significance of survivin as a prognostic factor and a therapeutic target in endometrial cancer
    Agapiti Hipoliti Chuwa
    Department of Obstetrics and Gynecology, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo Bunkyo, Tokyo 113 8655, Japan
    Gynecol Oncol 141:564-9. 2016
    ..We aimed to elucidate the prognostic importance of BIRC5 expression, and evaluate survivin as a therapeutic target for endometrial cancer, by knock-down of BIRC5 and using the survivin inhibitor-YM155...
  55. doi request reprint Glomus tumor of the ovary: a case report
    Daichi Maeda
    Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Int J Surg Pathol 18:557-60. 2010
    ..Although an ovarian glomus tumor is extremely rare, the authors believe that it should be included in the differential diagnosis of ovarian mesenchymal tumors and sex cord tumors...
  56. pmc Resveratrol promotes expression of SIRT1 and StAR in rat ovarian granulosa cells: an implicative role of SIRT1 in the ovary
    Yoshihiro Morita
    Department of Obstetrics and Gynecology, Graduate School of Medicine, The University of Tokyo, 7 3 1, Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Reprod Biol Endocrinol 10:14. 2012
    ..To date, the presence and physiological role of SIRT1 in the ovary are not known. Here we found that SIRT1 was localized in granulosa cells of the human ovary...
  57. ncbi request reprint Loss of Hugl-1 expression associates with lymph node metastasis in endometrial cancer
    Tetsushi Tsuruga
    Department of Obstetrics and Gynecology, Graduate School of Medicine, The University of Tokyo, Tokyo 113 8655, Japan
    Oncol Res 16:431-5. 2007
    ..These results indicate that loss of Hugl-1 expression in endometrial cancer may contribute to lymph node metastasis and it can be a factor of poor prognosis...
  58. ncbi request reprint Human homolog of Drosophila tumor suppressor Scribble negatively regulates cell-cycle progression from G1 to S phase by localizing at the basolateral membrane in epithelial cells
    Kazunori Nagasaka
    Department of Obstetrics and Gynecology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Cancer Sci 97:1217-25. 2006
    ..Our findings suggest the possibility that hScrib is involved in signal transduction to negatively regulate cell proliferation by localizing at the basolateral membrane of epithelial cells through LRRs and PDZ domains...
  59. doi request reprint Advanced age is a significant determinant of poor prognosis in patients treated with surgery plus postoperative radiotherapy for endometrial cancer
    Kae Okuma
    Department of Radiology, University of Tokyo Hospital, Hongo, Tokyo, Japan
    J Obstet Gynaecol Res 36:757-63. 2010
    ..A review was conducted in which the effect of age on survival was assessed in a population of endometrial cancer patients treated with surgery and adjuvant radiation therapy in our institution...
  60. doi request reprint Weekly administration of bevacizumab, gemcitabine, and oxaliplatin in patients with recurrent and refractory ovarian cancer: a preliminary result of 19 cases
    Yuji Ikeda
    Department of Obstetrics and Gynecology, Ohki Memorial Kikuchi Cancer Center for Women, Tokorozawa, Saitama, Japan
    Int J Gynecol Cancer 23:355-60. 2013
    ..Here, we evaluated the effect of weekly low-dose administration of GEMOX in combination with bevacizumab (B-GEMOX) for patients with recurrent and refractory ovarian cancers (ROCs)...
  61. ncbi request reprint Analysis of the status of the novel estrogen receptor α (ERα) coactivator p72 in endometrial cancer and its cross talk with erbB-2 in the transactivation of ERα
    Lin Zhao
    Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo, Tokyo 113 8655, Japan
    Mol Med Report 1:387-90. 2008
    ..These findings also suggest that the cooperative transactivation of ERα AF-1 by the overexpression of p72, AIB1 and erbB-2 might be involved in tamoxifen-stimulated growth of endometrial cancer...
  62. ncbi request reprint High frequency of coexistent mutations of PIK3CA and PTEN genes in endometrial carcinoma
    Katsutoshi Oda
    Cancer Research Institute, University of California San Francisco, San Francisco, California 94115, USA
    Cancer Res 65:10669-73. 2005
    ..Our data suggest that the PI3K pathway is extensively activated in endometrial carcinomas, and that combination of PIK3CA/PTEN alterations might play an important role in development of these tumors...
  63. doi request reprint Clinical significance of Gremlin 1 in cervical cancer and its effects on cancer stem cell maintenance
    Masakazu Sato
    Department of Obstetrics and Gynecology, Graduate School of Medicine, The University of Tokyo, Bunkyo ku, Tokyo 1138655, Japan
    Oncol Rep 35:391-7. 2016
    ..0184). Sphere-forming ability was increased when 1,000 Gremlin 1-exposed cells were seeded (P=0.0379). In cervical cancer, it is suggested that Gremlin 1 may have a role in clinical recurrence and maintaining CSC-like properties...
  64. doi request reprint [61-OR]: Functional regulation of trophoblast cells by lysophosphatidic acid signaling and its pathologic relevance to PIH
    Mayuko Ichikawa
    The University of Tokyo, Tokyo, Japan
    Pregnancy Hypertens 5:32. 2015
    ..We aimed to explore the regulatory role of trophoblast cell function by ATX-LPA-LAP3 pathway and its association with the pathology of pregnancy induced hypertension (PIH)...
  65. pmc Antitumor activity and induction of TP53-dependent apoptosis toward ovarian clear cell adenocarcinoma by the dual PI3K/mTOR inhibitor DS-7423
    Tomoko Kashiyama
    Department of Obstetrics and Gynecology, Faculty of Medicine, The University of Tokyo, Tokyo, Japan
    PLoS ONE 9:e87220. 2014
    ....
  66. doi request reprint SIRT3 positively regulates the expression of folliculogenesis- and luteinization-related genes and progesterone secretion by manipulating oxidative stress in human luteinized granulosa cells
    Houju Fu
    Department of Obstetrics and Gynecology H F, O W H, M H, A Sa, A Sh, Y M, W I, K Ko, K O, K Ka Y O, T F and the University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan Department of Physiological Chemistry and Metabolism Y K, W I, H K, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan Department of Obstetrics and Gynecology H O, T Y, National Center for Global Health and Medicine, 1 21 1 Toyama, Shinjyuku ku, Tokyo 162 8655, Japan
    Endocrinology 155:3079-87. 2014
    ..Activation of SIRT3 function might help to sustain human reproduction by maintaining GCs as well as oocytes. ..
  67. doi request reprint Claudin-18 overexpression in intestinal-type mucinous borderline tumour of the ovary
    Sultan Ahmad Halimi
    Department of Pathology, Faculty of Medicine, The University of Tokyo, Tokyo, Japan
    Histopathology 63:534-44. 2013
    ..In this study, we attempted to elucidate characteristics of the mucinous epithelium in each subtype...
  68. ncbi request reprint Second-line chemotherapy with docetaxel and carboplatin in paclitaxel and platinum-pretreated ovarian, fallopian tube, and peritoneal cancer
    Takahide Arimoto
    Department of Obstetrics and Gynecology, Faculty of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, 113 8655, Japan
    Med Oncol 29:1253-4. 2012
    ..On the other hand, single-agent chemotherapy would be better than this regimen considering its low response rate and severe hematological toxicity for patients with progression-free interval less than 6 months...
  69. doi request reprint Oral immunization with a Lactobacillus casei vaccine expressing human papillomavirus (HPV) type 16 E7 is an effective strategy to induce mucosal cytotoxic lymphocytes against HPV16 E7
    Katsuyuki Adachi
    Department of Obstetrics and Gynecology, Faculty of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Vaccine 28:2810-7. 2010
    ..This novel approach at a therapeutic HPV vaccine may achieve more effective clinical responses through its induction of mucosal E7-specific CTL...
  70. doi request reprint β-catenin (CTNNB1) S33C mutation in ovarian microcystic stromal tumors
    Daichi Maeda
    Department of Pathology, Graduate School of Medicine, The University of Tokyo, Japan
    Am J Surg Pathol 35:1429-40. 2011
    ..Finally, by comparing the immunophenotype of MCST with its histologic mimics and other ovarian sex cord-stromal tumors, we were able to identify unique features of MCST and a panel of markers useful in differential diagnosis...
  71. ncbi request reprint Safety and immunogenicity of a peptide containing the cross-neutralization epitope of HPV16 L2 administered nasally in healthy volunteers
    Kei Kawana
    Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, 113 8655, Tokyo 113 8655, Japan
    Vaccine 21:4256-60. 2003
    ..1mg group and the placebo group recipients. This study suggests the L2-108/120 peptide is tolerable in humans and has the potential as a broad-spectrum prophylactic vaccine against genital HPV...
  72. doi request reprint A case of successful detection of disseminated gastrointestinal stromal tumors by ascites smear cytology using cell block preparation with DOG1 immunostaining
    Shogo Tajima
    Department of Pathology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Diagn Cytopathol 44:137-40. 2016
    ..Immunostaining of c-kit did not provide as clear an identification of the tumor cells as DOG1 did. When suspicious about GISTs, it is wise to prepare a cell block to make it possible to visualize the tumor cells immunohistochemically...
  73. pmc Characterization of novel transcripts of human papillomavirus type 16 using cap analysis gene expression technology
    Ayumi Taguchi
    Department of Obstetrics and Gynecology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    J Virol 89:2448-52. 2015
    ..Here we have precisely identified a novel antisense noncoding viral transcript in HPV16. In conclusion, CAGE sequencing should pave the way for understanding a diversity of viral transcript expression. ..
  74. doi request reprint Cyclin-dependent kinase 4/6-specific activities as a biomarker for prognosis and chemosensitivity in endometrial cancer
    Yujio Ikeda
    The University of Tokyo, Tokyo, Japan
    Obstet Gynecol 123:92S. 2014
    ..We evaluated the clinical importance of CDK4/6 activity and its significance as a novel biomarker for the prognosis and chemosensitivity of endometrioid endometrial carcinoma...
  75. ncbi request reprint Comparison between conventional surgery and radiotherapy for FIGO stage I-II cervical carcinoma: a retrospective Japanese study
    Hideomi Yamashita
    Department of Radiology, University of Tokyo Hospital, 7 3 1 Hongo, Bunkyou ku, Tokyo 113 8655, Japan
    Gynecol Oncol 97:834-9. 2005
    ..To compare treatment outcome results of conventional surgery vs. radiotherapy (RT) for carcinoma of the uterine cervix...
  76. ncbi request reprint Distinct lymphatic spread of endometrial carcinoma in comparison with cervical and ovarian carcinomas
    Koji Matsumoto
    Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo, 7 3 1, Hongo, Bunkyo ku, Tokyo, Japan
    Cancer Lett 180:83-9. 2002
    ..Interestingly, EC can directly metastasize to both PLN and ALN with PLN metastases being dominant, a distinct lymphatic spread pattern better viewed as being somewhere between CC and OC...
  77. doi request reprint Effective treatment of pelvic lymphocele by lymphaticovenular anastomosis
    Takeshi Todokoro
    Department of Plastic and Reconstructive Surgery, The University of Tokyo, Tokyo, Japan
    Gynecol Oncol 128:209-14. 2013
    ..The aim of this study was to evaluate whether LVA is an effective treatment for lymphocele, which is caused by an obstruction of the lymphatic flow in a manner similar to the development of lymphedema...
  78. doi request reprint Expression of autotaxin, an ectoenzyme that produces lysophosphatidic acid, in human placenta
    Yuki Iwasawa
    Department of Obstetrics and Gynecology, Graduate School of Medicine, The University of Tokyo, Bunkyo ku, Tokyo, Japan
    Am J Reprod Immunol 62:90-5. 2009
    ..However, the source of increased ATX during pregnancy is still uncertain. We hypothesized that the source of increased ATX might be placenta...
  79. ncbi request reprint [Targeting Ras-PI3K/mTOR pathway and the predictive biomarkers in endometrial cancer]
    Katsutoshi Oda
    Dept of Obstetrics and Gynecology, The University of Tokyo, Tokyo, Japan
    Gan To Kagaku Ryoho 38:1084-7. 2011
    ....
  80. pmc Genome wide association study of age at menarche in the Japanese population
    Chizu Tanikawa
    Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan
    PLoS ONE 8:e63821. 2013
    ..In addition, six loci in or near CCDC85A, LOC100421670, CA10, ZNF483, ARNTL, and RXRG exhibited suggestive association with AAM (P<0.05). Our findings elucidated the impact of genetic variations on AAM in the Japanese population...
  81. doi request reprint Primary vaginal calculus in a middle-aged woman with mental and physical disabilities
    Yuji Ikeda
    Department of Obstetrics and Gynecology, Toma Hospital, 2 137 Hirosue, Kumagaya, Saitama 360 0031, Japan
    Int Urogynecol J 24:1229-31. 2013
    ..Results demonstrated the presence of a primary vaginal calculus. Vaginal calculi may occasionally occur in disabled women, but further investigation of the etiology of such calculi is required. ..