Hiroaki Nozawa

Summary

Affiliation: University of Tokyo
Country: Japan

Publications

  1. ncbi request reprint Detection of cancer cells in mesenteric vein and peripheral vessels by measuring telomerase activity in patients with colorectal cancer
    Hiroaki Nozawa
    Department of Surgical Oncology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Surgery 134:791-8. 2003
  2. ncbi request reprint Phosphorylation of ribosomal p70 S6 kinase and rapamycin sensitivity in human colorectal cancer
    Hiroaki Nozawa
    Department of Surgical Oncology, University of Tokyo, 7 3 1 Hongo, Bunkyu ku, Tokyo 113 8655, Japan
    Cancer Lett 251:105-13. 2007
  3. pmc Metachronous tubulovillous and tubular adenomas of the anal canal
    Hiroaki Nozawa
    Department of Surgical Oncology, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, 113 8655, Japan
    Diagn Pathol 10:139. 2015
  4. ncbi request reprint Large Colorectal Carcinoma Is Predictive of Recurrence After Adjuvant Chemotherapy Using Oxaliplatin
    Hiroaki Nozawa
    Department of Surgical Oncology, University of Tokyo, Bunkyo ku, Tokyo, Japan
    Anticancer Res 35:5073-8. 2015
  5. doi request reprint Outcome of salvage surgery for colorectal cancer initially treated by upfront endoscopic therapy
    Hiroaki Nozawa
    Department of Surgical Oncology, The University of Tokyo, Tokyo, Japan Electronic address
    Surgery 159:713-20. 2016
  6. pmc Laparoscopic resection of a gastrointestinal stromal tumor of the lower rectum in a patient with coronary artery disease following long-term neoadjuvant imatinib treatment and anticoagulation therapy
    Hiroaki Nozawa
    Department of Surgical Oncology, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    World J Surg Oncol 12:211. 2014
  7. doi request reprint Impact of chronic kidney disease on outcomes of surgical resection for primary colorectal cancer: a retrospective cohort review
    Hiroaki Nozawa
    Department of Surgical Oncology, The University of Tokyo, Hongo, Bunkyo ku, Tokyo, Japan
    Dis Colon Rectum 55:948-56. 2012
  8. pmc Pelvic actinomycosis presenting with a large abscess and bowel stenosis with marked response to conservative treatment: a case report
    Hiroaki Nozawa
    Department of Surgery, Odaira Memorial Tokyo Hitachi Hospital, Tokyo, Japan
    J Med Case Rep 1:141. 2007
  9. doi request reprint FOLFOX as adjuvant chemotherapy after curative resection of distant metastases in patients with colorectal cancer
    Hiroaki Nozawa
    Department of Surgical Oncology, The University of Tokyo, Tokyo, Japan
    Oncology 80:84-91. 2011
  10. doi request reprint Double primary adenocarcinomas of the jejunum and descending colon with lung metastases presenting rare immunohistochemical phenotypes: a case report
    Hiroaki Nozawa
    Department of Surgery, Odaira Memorial Tokyo Hitachi Hospital, Yushima, Bunkyo ku, Tokyo 113 0034, Japan
    Eur J Gastroenterol Hepatol 22:228-33. 2010

Collaborators

Detail Information

Publications73

  1. ncbi request reprint Detection of cancer cells in mesenteric vein and peripheral vessels by measuring telomerase activity in patients with colorectal cancer
    Hiroaki Nozawa
    Department of Surgical Oncology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Surgery 134:791-8. 2003
    ..The objective of this study was to assess whether colorectal cancer cells in the drainage veins can be detected by measuring telomerase activity and its detection is correlated with liver metastasis...
  2. ncbi request reprint Phosphorylation of ribosomal p70 S6 kinase and rapamycin sensitivity in human colorectal cancer
    Hiroaki Nozawa
    Department of Surgical Oncology, University of Tokyo, 7 3 1 Hongo, Bunkyu ku, Tokyo 113 8655, Japan
    Cancer Lett 251:105-13. 2007
    ..By immunohistochemical study, nearly 40% of adenomas and carcinomas of the colorectum exhibited either partial or whole positive staining for phospho-S6K, suggestive of rapamycin-sensitive lesions...
  3. pmc Metachronous tubulovillous and tubular adenomas of the anal canal
    Hiroaki Nozawa
    Department of Surgical Oncology, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, 113 8655, Japan
    Diagn Pathol 10:139. 2015
    ..Our case report underscores the importance of careful observations throughout colonoscopy to detect precancerous lesions, particularly in anatomically narrow segments. ..
  4. ncbi request reprint Large Colorectal Carcinoma Is Predictive of Recurrence After Adjuvant Chemotherapy Using Oxaliplatin
    Hiroaki Nozawa
    Department of Surgical Oncology, University of Tokyo, Bunkyo ku, Tokyo, Japan
    Anticancer Res 35:5073-8. 2015
    ..However, factors associated with recurrence despite adjuvant therapy are largely unknown...
  5. doi request reprint Outcome of salvage surgery for colorectal cancer initially treated by upfront endoscopic therapy
    Hiroaki Nozawa
    Department of Surgical Oncology, The University of Tokyo, Tokyo, Japan Electronic address
    Surgery 159:713-20. 2016
    ..The aim of our study was to evaluate the outcomes of salvage surgery in CRC patients treated initially by advanced therapeutic endoscopy...
  6. pmc Laparoscopic resection of a gastrointestinal stromal tumor of the lower rectum in a patient with coronary artery disease following long-term neoadjuvant imatinib treatment and anticoagulation therapy
    Hiroaki Nozawa
    Department of Surgical Oncology, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    World J Surg Oncol 12:211. 2014
    ..En bloc resection of the GIST was performed laparoscopically, which preserved the anus. The patient is currently alive without any evidence of relapse for 12 months after surgery. ..
  7. doi request reprint Impact of chronic kidney disease on outcomes of surgical resection for primary colorectal cancer: a retrospective cohort review
    Hiroaki Nozawa
    Department of Surgical Oncology, The University of Tokyo, Hongo, Bunkyo ku, Tokyo, Japan
    Dis Colon Rectum 55:948-56. 2012
    ..Chronic kidney disease, a disease entity increasing in number, may be an obstacle in various aspects of treatment for malignant neoplasm, such as perisurgical management and implementation of chemotherapy...
  8. pmc Pelvic actinomycosis presenting with a large abscess and bowel stenosis with marked response to conservative treatment: a case report
    Hiroaki Nozawa
    Department of Surgery, Odaira Memorial Tokyo Hitachi Hospital, Tokyo, Japan
    J Med Case Rep 1:141. 2007
    ..This is a successful case of symptomatic pelvic actinomycosis that was correctly diagnosed and treated without unnecessary surgical intervention...
  9. doi request reprint FOLFOX as adjuvant chemotherapy after curative resection of distant metastases in patients with colorectal cancer
    Hiroaki Nozawa
    Department of Surgical Oncology, The University of Tokyo, Tokyo, Japan
    Oncology 80:84-91. 2011
    ..The prophylactic effect of FOLFOX regimen, a standard regimen for unresectable colorectal cancer (CRC), was investigated in the adjuvant setting of CRC cases with distant metastases...
  10. doi request reprint Double primary adenocarcinomas of the jejunum and descending colon with lung metastases presenting rare immunohistochemical phenotypes: a case report
    Hiroaki Nozawa
    Department of Surgery, Odaira Memorial Tokyo Hitachi Hospital, Yushima, Bunkyo ku, Tokyo 113 0034, Japan
    Eur J Gastroenterol Hepatol 22:228-33. 2010
    ..Moreover, postoperative oxaliplatin, including chemotherapy, significantly reduced the lung metastases, suggesting that this regimen is a promising treatment option for advanced small bowel adenocarcinoma...
  11. doi request reprint Ischemic colitis following colonoscopy in an elderly patient on cardiovascular medication
    H Nozawa
    Department of Surgery, Odaira Memorial Tokyo Hitachi Hospital, Japan
    Endoscopy 39:E344-5. 2007
  12. ncbi request reprint [FOLFOX as adjuvant chemotherapy after curative resection of distant metastatic lesions in patients with colorectal cancer]
    Hiroaki Nozawa
    Department of Surgical Oncology, The University of Tokyo, Tokyo, Japan
    Gan To Kagaku Ryoho 38:1627-32. 2011
    ..03, p=0. 007, respectively). In conclusion, the FOLFOX regimen is more beneficial for CRC patients with synchronous metastasis as adjuvant chemotherapy than 5-FU (+LV) or other followup strategies...
  13. doi request reprint Hepatic steatosis is associated with lower incidence of liver metastasis from colorectal cancer
    Koji Murono
    Division of Surgical Oncology, Department of Surgery, Faculty of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Int J Colorectal Dis 28:1065-72. 2013
    ..The liver is the most frequent site of distant metastasis of CRC; however, the impact of HS on the incidence of liver metastasis of CRC is not clearly defined. Then, the correlation with the presence or absence of HS was analyzed...
  14. doi request reprint Hereditary gastrointestinal cancer
    Keisuke Hata
    Department of Surgical Oncology, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, 113 0033, Japan
    Surg Today 46:1115-22. 2016
    ....
  15. pmc Predictors and outcome of complete removal of colorectal cancer with synchronous lung metastases
    Hiroaki Nozawa
    Department of Surgical Oncology, The University of Tokyo, Tokyo 113 8655, Japan
    Mol Clin Oncol 3:1041-1047. 2015
    ..Furthermore, palliative resection may contribute to a better prognosis compared to stoma surgery alone in selected cases...
  16. ncbi request reprint Survival Impact of Extracolorectal Malignancies in Colorectal Cancer Patients
    Kazushige Kawai
    Department of Surgical Oncology, Faculty of Medicine, The University of Tokyo, Tokyo, Japan
    Digestion 94:92-99. 2016
    ..Although development of a second primary cancer and deaths thereof are included as events of disease-free survival (DFS) and overall survival (OS), the role of EMs in these survival end points has not been fully investigated...
  17. doi request reprint Colorectal cancer with venous tumor thrombosis
    Kensuke Otani
    Department of Surgical Oncology, University of Tokyo, Tokyo, Japan Electronic address
    Asian J Surg . 2016
    ..A greater accumulation of cases will help elucidate the characteristics of colorectal cancer with venous tumor thrombosis and improve the treatment strategy...
  18. ncbi request reprint Short-term outcomes of open versus laparoscopic surgery in elderly patients with colorectal cancer
    Takeshi Nishikawa
    Department of Surgical Oncology, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, 113 8655, Japan
    Surg Endosc 30:5550-5557. 2016
    ..Our purpose is to verify the safety and effectiveness of laparoscopic surgery for the treatment of colorectal cancer in elderly patients...
  19. ncbi request reprint A high preoperative carbohydrate antigen 19-9 level is a risk factor for recurrence in stage II colorectal cancer
    Hiroaki Nozawa
    a Department of Surgical Oncology, The University of Tokyo, Tokyo, Japan
    Acta Oncol . 2016
    ..This study aimed to identify risk factors for tumor recurrence and assess whether they are related to the benefits of adjuvant chemotherapy in stage II CRC...
  20. pmc Level of arterial ligation in sigmoid colon and rectal cancer surgery
    Koji Yasuda
    Department of Surgical Oncology, Faculty of Medicine, The University of Tokyo Hospital, 7 3 1 Hongo, Bunkyo ku, Tokyo, 113 0033, Japan
    World J Surg Oncol 14:99. 2016
    ..The aim of this study was to assess the utility of "low tie with LND" on survival in patients with sigmoid colon or rectal cancer...
  21. ncbi request reprint Adiponectin and colorectal cancer
    Kensuke Otani
    Department of Surgical Oncology, The University of Tokyo, Hongo7 3 1, Bunkyo ku, Tokyo, 113 8655, Japan
    Surg Today . 2016
    ..In this report, we summarize recent findings of the correlation between adiponectin and colorectal cancer and investigate the effect of adiponectin on colorectal cancer...
  22. pmc Laparoscopy-assisted versus open surgery for multiple colorectal cancers with two anastomoses: a cohort study
    Hiroaki Nozawa
    Department of Surgical Oncology, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, 113 8655 Japan
    Springerplus 5:287. 2016
    ..Our results suggest that laparoscopy-assisted combined resection is an acceptable alternative to open surgery for multiple colorectal cancers. ..
  23. doi request reprint Clinicopathological Features of Colorectal Cancer Patients Under the Age of 50: Recent Experience and Case-Control Study of Prognosis in a Japanese Cohort
    Yuzo Nagai
    Department of Surgical Oncology, Faculty of Medicine, The University of Tokyo, Tokyo, Japan
    Digestion 93:272-9. 2016
    ..The incidence of colorectal cancer (CRC) in young people is increasing, indicating an urgent need for understanding young-onset CRC. This study serves to clarify the characteristics and prognosis of young CRC patients...
  24. ncbi request reprint Anatomy of the middle rectal artery: a review of the historical literature
    Tomomichi Kiyomatsu
    Department of Surgical Oncology, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, 113 8655, Japan
    Surg Today 47:14-19. 2017
    ..With advancements in endoscopic surgery, the knowledge of the precise anatomy of this structure is becoming more crucial for optimal rectal cancer surgery...
  25. ncbi request reprint Laparoscopic versus open surgery for obese patients with rectal cancer: a retrospective cohort study
    Hiroyuki Matsuzaki
    Department of Surgical Oncology, The University of Tokyo Hospital, 7 3 1 Hongo, Bunkyo ku, Tokyo, 113 8655, Japan
    Surg Today . 2016
    ..To evaluate the advantages of laparoscopic surgery for rectal cancer in obese patients...
  26. doi request reprint Evaluation of the vascular anatomy of the right-sided colon using three-dimensional computed tomography angiography: a single-center study of 536 patients and a review of the literature
    Koji Murono
    Division of Surgical Oncology, Department of Surgery, Faculty of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, 113 8655, Japan
    Int J Colorectal Dis 31:1633-8. 2016
    ..Three-dimensional (3D)-computed tomography (CT) angiography is a less-invasive modality than traditional angiographic examination. Therefore, we aimed to evaluate branching patterns of the superior mesenteric artery (SMA)...
  27. doi request reprint Small colorectal cancers resembling submucosal tumor with massive submucosal invasion and lymph node metastasis: A report of two cases and review of the literature
    Takahide Shinagawa
    Department of Surgical Oncology, The University of Tokyo, 7 3 1, Hongo, Bunkyo ku, 113 8655 Tokyo, Japan Electronic address
    Clin Res Hepatol Gastroenterol . 2016
    ..Therefore, surgical treatment with dissection of the regional lymph nodes might be necessary in cases with any signs of massive submucosal invasion...
  28. doi request reprint Paradoxical Reductions in Serum Anti-p53 Autoantibody Levels by Chemotherapy in Unresectable Colorectal Cancer: An Observational Study
    Hiroaki Nozawa
    Department of Surgical Oncology, The University of Tokyo, Tokyo, Japan
    Oncology 91:127-34. 2016
    ..The usefulness of this antibody has been suggested in screening for and the monitoring of recurrence in colorectal cancer; however, its significance as a marker during chemotherapy remains largely unknown...
  29. doi request reprint Intraoperative colonoscopy in patients with colorectal cancer: Review of recent developments
    Kazushige Kawai
    Department of Surgical Oncology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Dig Endosc 28:633-40. 2016
    ....
  30. pmc Incidence of neoplasias and effectiveness of postoperative surveillance endoscopy for patients with ulcerative colitis: comparison of ileorectal anastomosis and ileal pouch-anal anastomosis
    Hiroaki Ishii
    Department of Surgical Oncology, Faculty of Medicine, The University of Tokyo, Tokyo, 113 0033, Japan
    World J Surg Oncol 14:75. 2016
    ....
  31. doi request reprint Prognostic significance of the lymph node ratio in stage IV colorectal cancer patients who have undergone curative resection
    Tsuyoshi Ozawa
    Department of Surgical Oncology, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo Bunkyo ku, Tokyo, 113 8655, Japan
    Ann Surg Oncol 22:1513-9. 2015
    ..The purpose of this study was to evaluate the prognostic impact of the LNR in Stage IV CRC patients who have undergone curative resection...
  32. pmc Nomograms for colorectal cancer: A systematic review
    Kazushige Kawai
    Kazushige Kawai, Eiji Sunami, Hironori Yamaguchi, Soichiro Ishihara, Shinsuke Kazama, Hiroaki Nozawa, Keisuke Hata, Tomomichi Kiyomatsu, Junichiro Tanaka, Toshiaki Tanaka, Takeshi Nishikawa, Joji Kitayama, Toshiaki Watanabe, Department of Surgical Oncology, Graduate School of Medicine, The University of Tokyo, Tokyo 113 0033, Japan
    World J Gastroenterol 21:11877-86. 2015
    ..To assist in the selection of suitable nomograms for obtaining desired predictions in daily clinical practice...
  33. doi request reprint 'Deepness of Response' Is Associated with Overall Survival in Standard Systemic Chemotherapy for Metastatic Colorectal Cancer
    Hiroaki Nozawa
    Department of Surgical Oncology, The University of Tokyo, Tokyo, Japan
    Chemotherapy 60:360-7. 2014
    ..We determined whether this concept was universally applicable to diverse standard chemotherapeutic regimens for mCRC...
  34. doi request reprint The preoperative platelet to lymphocyte ratio is a prognostic marker in patients with stage II colorectal cancer
    Tsuyoshi Ozawa
    Department of Surgical Oncology, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo Bunkyo ku, Tokyo, 113 8655, Japan
    Int J Colorectal Dis 30:1165-71. 2015
    ..The aim of this study was to evaluate the prognostic impact of the PLR in patients with stage II colorectal cancer (CRC) who have undergone curative resection but not adjuvant chemotherapy...
  35. doi request reprint Laparoscopic surgery for ulcerative colitis: a review of the literature
    Keisuke Hata
    Department of Surgical Oncology, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, 113 8655, Japan
    Surg Today 45:933-8. 2015
    ..Some surgeons favor laparoscopic surgery even for severe acute colitis. More efforts are being made to develop newer laparoscopic methods, such as reduced port surgery, including single incision laparoscopic surgery and robotic surgery. ..
  36. ncbi request reprint CD133 Expression in Lymph Node Metastases Is Associated with Tumor Aggressiveness During Lymph Node Metastasis in Colorectal Cancer
    Shinsuke Kazama
    Division of Surgical Oncology, Department of Surgery, Faculty of Medicine, The University of Tokyo, Bunkyo ku, Tokyo, Japan
    Anticancer Res 35:6599-605. 2015
    ..However, the expression of CD133 in lymph node metastases as well as in primary tumors in CRC remains to be elucidated...
  37. doi request reprint Temsirolimus and chloroquine cooperatively exhibit a potent antitumor effect against colorectal cancer cells
    Manabu Kaneko
    Department of Surgical Oncology, Faculty of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, 113 8655, Japan
    J Cancer Res Clin Oncol 140:769-81. 2014
    ....
  38. doi request reprint One-stage segmental colectomy and primary anastomosis after intraoperative colonic irrigation and total colonoscopy for patients with obstruction due to left-sided colorectal cancer
    Kazuhito Sasaki
    Department of Surgical Oncology, Faculty of Medicine, The University of Tokyo, Tokyo, Japan
    Dis Colon Rectum 55:72-8. 2012
    ....
  39. pmc Colonic perforation in a patient with systemic lupus erythematosus accompanied by cytomegalovirus infection: A case report
    Yuichi Tachikawa
    Department of Surgical Oncology, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan Electronic address
    Int J Surg Case Rep 23:70-3. 2016
    ..Systemic lupus erythematosus (SLE) patients are generally at high risk of CMV infection. Here we report a subacute progressive case of colitis in SLE accompanied by cytomegalovirus infection...
  40. pmc A case report of anorectal malignant melanoma with mucosal skipped lesion
    Keiichi Arakawa
    University of Tokyo, Department of Surgical Oncology, Tokyo, Japan Electronic address
    Int J Surg Case Rep 24:206-10. 2016
    ..We report our experience involving a case of relatively rare anorectal malignant melanoma with skipped lesion...
  41. pmc A case of disseminated carcinomatosis of the bone marrow originating from gastric cancer 3 years after intraperitoneal chemotherapy against peritoneal carcinomatosis
    Takayuki Okuno
    Department of Surgical Oncology, The University of Tokyo, 7 3 1 Bunkyo ku, Tokyo, 113 8655, Japan
    World J Surg Oncol 14:107. 2016
    ..Disseminated carcinomatosis of the bone marrow is highly rare in gastric cancer and associated with a poor prognosis...
  42. ncbi request reprint Clinical significance of mucinous components in rectal cancer after preoperative chemoradiotherapy
    Kensuke Kaneko
    Department of Surgical Oncology, Faculty of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, 113 8655, Japan
    Surg Today . 2016
    ..The clinical implications of mucinous components in rectal tumors, especially with regard to the efficacy of neoadjuvant chemoradiotherapy, remain unclear...
  43. doi request reprint Pouchitis after ileal pouch-anal anastomosis in ulcerative colitis: diagnosis, management, risk factors, and incidence
    Keisuke Hata
    Department of Surgical Oncology, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, 113 8655, Japan
    Dig Endosc . 2016
    ..This article is protected by copyright. All rights reserved...
  44. ncbi request reprint Anal metastasis from rectal adenocarcinoma
    Takeshi Nishikawa
    Department of Surgical Oncology, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, 113 8655, Japan
    Clin J Gastroenterol 9:379-383. 2016
    ..In the next procedure, she had the liver lesions resected. This case suggested the importance of the careful examination of the anus during colonoscopy, or digital examination for the detection of anal metastasis...
  45. pmc Giant mucocele of the colon at the distal stump due to low-grade mucinous neoplasia
    Toshiaki Tanaka
    Department of Surgical Oncology, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, Japan
    Surg Case Rep 2:117. 2016
    ..With reference to low-grade mucinous neoplasia, we propose that complete surgical resection be performed for diagnosis and a favorable outcome...
  46. pmc Successful endoscopic treatment of stapled J-pouch ileoanal canal anastomotic hemorrhage by argon plasma coagulation: a case report
    Takeshi Nishikawa
    Department of Surgical Oncology, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, 113 8655, Japan
    J Med Case Rep 10:309. 2016
    ..We report a case of a patient with gastrointestinal hemorrhage 18 years after stapled J-pouch ileoanal canal anastomosis who was successfully treated with argon plasma coagulation...
  47. ncbi request reprint Survival and Prognostic Factors for Metachronous Peritoneal Metastasis in Patients with Colon Cancer
    Hiroshi Nagata
    Department of Surgical Oncology, The University of Tokyo, Bunkyo, Tokyo, Japan
    Ann Surg Oncol . 2016
    ..The clinical course of metachronous peritoneal metastasis of colorectal origin is poorly understood. In this retrospective study, we aimed to elucidate survival and prognostic factors for metachronous peritoneal metastasis...
  48. doi request reprint LINE-1 hypomethylation status of circulating cell-free DNA in plasma as a biomarker for colorectal cancer
    Yuzo Nagai
    Department of Surgical Oncology, Faculty of Medicine, The University of Tokyo, Bunkyo ku, Tokyo, Japan
    Oncotarget . 2017
    ..79 and 0.83 in stage I/II and stage III/IV CRC patients, respectively. The present study demonstrated for the first time the potential of plasma cfDNA LHI as a novel biomarker for CRC, particularly for early stage detection...
  49. pmc Effect of nutrient starvation on proliferation and cytokine secretion of peripheral blood lymphocytes
    Yoshiko Ota
    Department of Surgical Oncology, The University of Tokyo Hospital, Tokyo 113 8655, Japan
    Mol Clin Oncol 4:607-610. 2016
    ..It is therefore possible that glucose-deficient microenvironments in local cancer tissues cause a partial immunodeficiency, which is advantageous to cancer growth...
  50. pmc Asynchronous bilateral anastomosis site sigmoid colon cancer after ureterosigmoidostomy: a case report
    Keiichi Arakawa
    Department of Surgical Oncology, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, 113 8655, Japan
    World J Surg Oncol 14:180. 2016
    ..We present a case of asynchronously occurring adenocarcinomas 29 and 36 years after ureterosigmoidostomy for bladder cancer, respectively, at both anastomosis sites...
  51. pmc Efficacy of magnetic resonance imaging in the diagnosis of perianal hidradenitis suppurativa, complicated by anal fistulae: A report of two cases and review of the literature
    Hirotoshi Takiyama
    Department of Surgical Oncology, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan Electronic address
    Int J Surg Case Rep 15:107-11. 2015
    ..It is difficult to treat perianal lesions merged with fistulae completely due to its high recurrence rate. Therefore, we should diagnose it correctly and treat it with appropriate methods...
  52. doi request reprint Surveillance colonoscopy for colitis-associated dysplasia and cancer in ulcerative colitis patients
    Keisuke Hata
    Department of Surgical Oncology, The University of Tokyo, Tokyo, Japan
    Dig Endosc 28:260-5. 2016
    ..In the present review, we focus on the current detection methods and characterization of dysplasia/cancer and discuss the appropriate intervals of colonoscopy according to the stratified risks. ..
  53. pmc Small bowel adenocarcinoma arising in a patient with hereditary hemorrhagic telangiectasia: A case report
    Yuichiro Yoshioka
    Department of Surgical Oncology, University of Tokyo, Tokyo 113 8655, Japan
    Oncol Lett 11:2137-2139. 2016
    ..This patient with SBA was an instructive case demonstrating the necessity of careful attention during major surgery in HHT...
  54. doi request reprint Prognostic Impact of Histologic Type in Curatively Resected Stage IV Colorectal Cancer: A Japanese Multicenter Retrospective Study
    Junichi Shibata
    Department of Surgical Oncology, University of Tokyo Hospital, The University of Tokyo, Tokyo, Japan
    Ann Surg Oncol 22:S621-9. 2015
    ..This study aimed to clarify differences in prognostic factors, metastatic features, and recurrence rates between histologic types in patients with stage 4 colorectal cancer (CRC) who had undergone curative resection...
  55. pmc Alpha-fetoprotein-producing early rectal carcinoma: a rare case report and review
    Hiroyuki Anzai
    Division of Surgical Oncology, Department of Surgery, Faculty of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, 113 8655, Japan
    World J Surg Oncol 13:180. 2015
    ..Alpha-fetoprotein (AFP)-producing rectal cancer is very rare, and this type of cancer frequently metastasizes to the liver with a poor prognosis. To date, only 11 cases of AFP-producing colorectal cancer have been reported...
  56. doi request reprint Recent advances in robotic surgery for rectal cancer
    Soichiro Ishihara
    Department of Surgical Oncology, The University of Tokyo Hospital, 7 3 1, Bunkyo ku, Hongo, Tokyo, 113 8655, Japan
    Int J Clin Oncol 20:633-40. 2015
    ..However, long-term outcomes and the cost-effectiveness of robotic surgery for rectal cancer have not been fully evaluated yet; therefore, large-scale clinical studies are required to evaluate the efficacy of this new technology. ..
  57. pmc A patient with gastric cancer with peritoneal carcinomatosis treated with intraperitoneal chemotherapy who survived more than 5 years receiving repeated laparoscopic examinations: a case report
    Hironori Yamaguchi
    Department of Surgical Oncology, The University of Tokyo, 7 3 1 Bunkyo ku, Hongo, Tokyo, 113 8655, Japan
    J Med Case Rep 10:14. 2016
    ..This is the first report of a case of a patient with gastric cancer with massive peritoneal metastasis treated with intraperitoneal administration of paclitaxel and repeated laparoscopic examinations who survived more than 5 years...
  58. doi request reprint Incidence and prognostic significance of positive peritoneal lavage in colorectal cancer
    Takeshi Nishikawa
    Department of Surgical Oncology, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, 113 8655, Japan
    Surg Today 45:1073-81. 2015
    ..However, the meaning of positive peritoneal lavage cytology in colorectal cancer is still controversial. The aim of this review is to evaluate the prognostic significance of positive peritoneal lavage cytology in colorectal cancer...
  59. doi request reprint Patient factors predisposing to complications following laparoscopic surgery for colorectal cancers
    Soichiro Ishihara
    Department of Surgical Oncology, The University of Tokyo Hospital, Hongo, Bunkyo ku Department of Surgery, Teikyo University, Kaga, Itabashi ku, Tokyo, Japan
    Surg Laparosc Endosc Percutan Tech 25:168-72. 2015
    ..91, P=0.0102) and cancer stage (stage 2/stage 4: OR=0.17, P=0.0247) were risk factors for noninfectious complications. This study shows that different patient factors are associated with the risk of different types of complications. ..
  60. doi request reprint Prognostic impact of carcinoembryonic antigen and carbohydrate antigen 19-9 in stage IV colorectal cancer patients after R0 resection
    Shinya Abe
    Department of Surgical Oncology, Faculty of Medicine, The University of Tokyo, Tokyo, Japan Electronic address
    J Surg Res 205:384-92. 2016
    ..The aim of this study was to evaluate the predictive abilities of post-CEA and post-CA 19-9...
  61. ncbi request reprint Prognostic Value of Pre- and Postoperative Anti-p53 Antibody Levels in Colorectal Cancer Patients: A Retrospective Study
    Shinya Abe
    Department of Surgical Oncology, Faculty of Medicine, The University of Tokyo Hospital, Tokyo, Japan
    Oncology . 2016
    ..To determine the utility of the post-/preoperative anti-p53 antibody (p53 Ab) ratio as a prognostic factor for colorectal cancer (CRC) recurrence...
  62. doi request reprint Perforation of jejunal diverticulum with ectopic pancreas
    Hiroshi Shiratori
    Department of Surgical Oncology, Faculty of Medicine, The University of Tokyo, 3 1 Hongo 7 chome, Bunkyo ku, Tokyo, 113 8655, Japan
    Clin J Gastroenterol . 2017
    ..This rare case shows that the ectopic pancreas might have caused penetration of jejunal diverticulum owing to the pancreatic duct opening through the diverticulum...
  63. doi request reprint Comparison of Functional Outcomes of Patients Who Underwent Hand-Sewn or Stapled Ileal Pouch-Anal Anastomosis for Ulcerative Colitis
    Hiroaki Ishii
    1 Department of Surgical Oncology, Faculty of Medicine, The University of Tokyo, Tokyo, Japan
    Int Surg 100:1169-76. 2015
    ..Postoperative complications, functional outcomes, and long-term QOL were similar in patients who had received hand-sewn or stapled IPAA. ..
  64. pmc A case of extraperitoneal stoma-associated internal hernia after abdominoperineal resection
    Yuichiro Yokoyama
    Division of Surgical Oncology, Department of Surgery, Faculty of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    World J Surg Oncol 12:141. 2014
    ..The strangulated portion of the small intestine was recovered, and the orifice of herniation was closed. No recurrence of internal herniation was observed during the follow-up period. ..
  65. doi request reprint Mesalazine-induced Pleuropericarditis in a Patient with Crohn's Disease
    Hidemichi Kiyomatsu
    Department of Surgical Oncology, Faculty of Medicine, The University of Tokyo, Japan
    Intern Med 54:1605-8. 2015
    ..After the cessation of mesalazine, the clinical symptoms and laboratory findings quickly improved. ..
  66. ncbi request reprint Phospholipase A2 Group III and Group X Have Opposing Associations with Prognosis in Colorectal Cancer
    Shinsuke Kazama
    Division of Surgical Oncology, Department of Surgery, Faculty of Medicine, The University of Tokyo, Bunkyo ku, Tokyo, Japan
    Anticancer Res 35:2983-90. 2015
    ..Although secretory phospholipase A2 (sPLA2) has been shown to be involved in various biological processes, its specific roles in sub-types of cancer development remain to be elucidated...
  67. doi request reprint Nuclear Notch3 expression is associated with tumor recurrence in patients with stage II and III colorectal cancer
    Tsuyoshi Ozawa
    Department of Surgical Oncology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Ann Surg Oncol 21:2650-8. 2014
    ..In the present study, we investigated Notch1 and Notch3 expression in Stage II and III CRC to assess their association with clinicopathological characteristics...
  68. ncbi request reprint Telomerase activity of blood samples and recurrence of colorectal cancer
    Tatsuya Ohnishi
    Department of Surgical Oncology, University of Tokyo Graduate School of Medicine, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Hepatogastroenterology 55:1513-8. 2008
    ....
  69. ncbi request reprint Telomerase subunit immunoreactivity and recurrence in colorectal cancer
    Tatsuya Ohnishi
    Department of Surgical Oncology, University of Tokyo Graduate School of Medicine, Tokyo, Japan
    Hepatogastroenterology 53:188-91. 2006
    ..In this study we attempted to show by means of immunohistochemistry the association between hTERT expression and recurrence in 128 colorectal cancer patients surgically treated in the University of Tokyo Hospital...
  70. pmc High RAD54B expression: an independent predictor of postoperative distant recurrence in colorectal cancer patients
    Yuzo Nagai
    Department of Surgical Oncology, Faculty of Medicine, The University of Tokyo, Hongo, Bunkyo ku, Tokyo, Japan
    Oncotarget 6:21064-73. 2015
    ..This study first demonstrated RAD54B expression has potential to serve as a novel prognostic biomarker, particularly for distant recurrence in CRC patients. ..
  71. doi request reprint Elevated neutrophil to lymphocyte ratio predicts poor prognosis in advanced colorectal cancer patients receiving oxaliplatin-based chemotherapy
    Manabu Kaneko
    Department of Surgical Oncology, Faculty of Medicine, University of Tokyo, Tokyo, Japan m kaneko fancy ocn ne jp
    Oncology 82:261-8. 2012
    ..The aim of this study was to assess whether the neutrophil to lymphocyte ratio (NLR) and other laboratory markers may predict the prognosis of advanced colorectal cancer (CRC) patients receiving palliative chemotherapy...
  72. doi request reprint Critical role for constitutive type I interferon signaling in the prevention of cellular transformation
    Hui Min Chen
    Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Tokyo, Japan
    Cancer Sci 100:449-56. 2009
    ....
  73. ncbi request reprint Dihydropyrimidine dehydrogenase expression in preoperative biopsy and surgically resected specimens of gastric carcinoma
    Hiroaki Nozawa
    Department of Surgery, Tokyo Postal Services Agency Hospital, 2 14 23 Fujimi, Chiyoda ku, Tokyo 102 8798, Japan
    Cancer Chemother Pharmacol 49:267-73. 2002
    ..We investigated preoperative biopsy and surgically resected specimens of gastric carcinomas immunohistochemically for the expression of DPD...