Nao Nishida

Summary

Affiliation: University of Tokyo
Country: Japan

Publications

  1. ncbi request reprint Polymorphisms of promoter and coding regions of the arylamine N-acetyltransferase 2 (NAT2) gene in the Indonesian population: proposal for a new nomenclature
    Rika Yuliwulandari
    Department of Human Genetics, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, Japan
    J Hum Genet 53:201-9. 2008
  2. doi request reprint Linkage disequilibrium structure of the 5q31-33 region in a Thai population
    Pornlada Nuchnoi
    Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    J Hum Genet 53:850-6. 2008
  3. pmc Genome-wide association study confirming association of HLA-DP with protection against chronic hepatitis B and viral clearance in Japanese and Korean
    Nao Nishida
    Research Center for Hepatitis and Immunology, National Center for Global Health and Medicine, Ichikawa, Chiba, Japan
    PLoS ONE 7:e39175. 2012
  4. pmc Highly parallel and short-acting amplification with locus-specific primers to detect single nucleotide polymorphisms by the DigiTag2 assay
    Nao Nishida
    Department of Human Genetics, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    PLoS ONE 7:e29967. 2012
  5. pmc Identification of a haplotype block in the 5q31 cytokine gene cluster associated with the susceptibility to severe malaria
    Izumi Naka
    Doctoral Programme in Life System Medical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Ibaraki, Japan
    Malar J 8:232. 2009
  6. ncbi request reprint DigiTag assay for multiplex single nucleotide polymorphism typing with high success rate
    Nao Nishida
    Department of Human Genetics, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Anal Biochem 346:281-8. 2005
  7. ncbi request reprint Further development of multiplex single nucleotide polymorphism typing method, the DigiTag2 assay
    Nao Nishida
    Department of Human Genetics, Graduate School of Medicine, University of Tokyo, Bunkyo ku, Tokyo 113 0033, Japan
    Anal Biochem 364:78-85. 2007
  8. pmc Evaluating the performance of Affymetrix SNP Array 6.0 platform with 400 Japanese individuals
    Nao Nishida
    Department of Human Genetics, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    BMC Genomics 9:431. 2008
  9. doi request reprint Association study of PDE4B with panic disorder in the Japanese population
    Takeshi Otowa
    Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, Tokyo 113 8655, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 35:545-9. 2011
  10. doi request reprint C/EBPβ and RUNX2 cooperate to degrade cartilage with MMP-13 as the target and HIF-2α as the inducer in chondrocytes
    Makoto Hirata
    Sensory and Motor System Medicine, University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo 113 8655, Japan
    Hum Mol Genet 21:1111-23. 2012

Detail Information

Publications37

  1. ncbi request reprint Polymorphisms of promoter and coding regions of the arylamine N-acetyltransferase 2 (NAT2) gene in the Indonesian population: proposal for a new nomenclature
    Rika Yuliwulandari
    Department of Human Genetics, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, Japan
    J Hum Genet 53:201-9. 2008
    ..U1, NAT2*4.U2, NAT2*4.U3, NAT2*4.U5, NAT2*4.U6, NAT2*4.U7, NAT2*6A.U1, NAT2*7B.U2, NAT2*7B.U3, NAT2*5B.U1, NAT2*5B.U4, NAT2*12A.U4 and NAT2*13.U1...
  2. doi request reprint Linkage disequilibrium structure of the 5q31-33 region in a Thai population
    Pornlada Nuchnoi
    Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    J Hum Genet 53:850-6. 2008
    ..Our results suggest that tagging SNPs from CHB + JPT (Northeast Asians) can efficiently capture common variants in Southeast Asians, and that the HapMap data are useful for association studies in Southeast Asian populations...
  3. pmc Genome-wide association study confirming association of HLA-DP with protection against chronic hepatitis B and viral clearance in Japanese and Korean
    Nao Nishida
    Research Center for Hepatitis and Immunology, National Center for Global Health and Medicine, Ichikawa, Chiba, Japan
    PLoS ONE 7:e39175. 2012
    ..To clarify the pathogenesis of CHB and the mechanisms of HBV clearance, further studies are necessary, including functional analyses of the HLA-DP molecule...
  4. pmc Highly parallel and short-acting amplification with locus-specific primers to detect single nucleotide polymorphisms by the DigiTag2 assay
    Nao Nishida
    Department of Human Genetics, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    PLoS ONE 7:e29967. 2012
    ..Moreover, highly parallel and short-acting amplification with locus-specific primers may thus facilitate widespread application to other PCR-based assays...
  5. pmc Identification of a haplotype block in the 5q31 cytokine gene cluster associated with the susceptibility to severe malaria
    Izumi Naka
    Doctoral Programme in Life System Medical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Ibaraki, Japan
    Malar J 8:232. 2009
    ....
  6. ncbi request reprint DigiTag assay for multiplex single nucleotide polymorphism typing with high success rate
    Nao Nishida
    Department of Human Genetics, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Anal Biochem 346:281-8. 2005
    ..Moreover, this assay has the potential to analyze almost all kinds of the target SNPs by applying mismatch-induced probes and redesigned primer pairs at a low-cost...
  7. ncbi request reprint Further development of multiplex single nucleotide polymorphism typing method, the DigiTag2 assay
    Nao Nishida
    Department of Human Genetics, Graduate School of Medicine, University of Tokyo, Bunkyo ku, Tokyo 113 0033, Japan
    Anal Biochem 364:78-85. 2007
    ..The DigiTag2 assay is suitable for genotyping an intermediate number of SNPs (tens to hundreds of sites) with a high conversion rate (>90%), high accuracy, and low cost...
  8. pmc Evaluating the performance of Affymetrix SNP Array 6.0 platform with 400 Japanese individuals
    Nao Nishida
    Department of Human Genetics, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    BMC Genomics 9:431. 2008
    ..0 platform and the genotype calling algorithm "Birdseed"...
  9. doi request reprint Association study of PDE4B with panic disorder in the Japanese population
    Takeshi Otowa
    Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, Tokyo 113 8655, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 35:545-9. 2011
    ..Several studies indicated that PDE4B may be involved in the regulation of anxiety and depression. Therefore, we investigate the association of PDE4B with PD in the Japanese population...
  10. doi request reprint C/EBPβ and RUNX2 cooperate to degrade cartilage with MMP-13 as the target and HIF-2α as the inducer in chondrocytes
    Makoto Hirata
    Sensory and Motor System Medicine, University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo 113 8655, Japan
    Hum Mol Genet 21:1111-23. 2012
    ..Hence, C/EBPβ and RUNX2, with MMP-13 as the target and HIF-2α as the inducer, control cartilage degradation. This molecular network in chondrocytes may represent a therapeutic target for OA...
  11. doi request reprint Model incorporating the ITPA genotype identifies patients at high risk of anemia and treatment failure with pegylated-interferon plus ribavirin therapy for chronic hepatitis C
    Masayuki Kurosaki
    Department of Gastroenterology and Hepatology, Musashino Red Cross Hospital, Tokyo, Japan
    J Med Virol 85:449-58. 2013
    ..In conclusion, a predictive model incorporating the ITPA genotype could identify patients with a high risk of anemia and reduced probability of sustained virological response...
  12. doi request reprint FGFR2 is associated with hair thickness in Asian populations
    Akihiro Fujimoto
    Computational Science Research Program, RIKEN, Tokyo, Japan
    J Hum Genet 54:461-5. 2009
    ..0270). These results suggest that the FGFR2 polymorphism affects the variation in hair thickness in Asia through alteration in the expression level of FGFR2...
  13. doi request reprint The serum leptin level and body mass index in Melanesian and Micronesian Solomon Islanders: focus on genetic factors and urbanization
    Takuro Furusawa
    Network for Education and Research on Asia, The University of Tokyo, Institute for Advanced Studies on Asia, The University of Tokyo, Japan
    Am J Hum Biol 23:435-44. 2011
    ....
  14. doi request reprint Genome-wide association study of panic disorder in the Japanese population
    Takeshi Otowa
    Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    J Hum Genet 54:122-6. 2009
    ..Studies with other samples are required to confirm the results...
  15. doi request reprint Genome-wide association database developed in the Japanese Integrated Database Project
    Asako Koike
    Central Research Laboratory, Hitachi Ltd, Tokyo, Japan
    J Hum Genet 54:543-6. 2009
    ..The same data are also managed as a distributed annotation system to call up useful data from other DBs and to superimpose them on the GWAS data for help in interpretation. The DB is accessible at https://gwas.lifesciencedb.jp/...
  16. doi request reprint Appropriate data cleaning methods for genome-wide association study
    Taku Miyagawa
    Department of Human Genetics, Graduate School of Medicine, The University of Tokyo, Tokyo, 113 0033, Japan
    J Hum Genet 53:886-93. 2008
    ..We found that appropriate data cleaning could be achieved using these four parameters. Our findings offer an avenue for obtaining appropriate data from GWAS...
  17. doi request reprint Association of IL28B variants with response to pegylated-interferon alpha plus ribavirin combination therapy reveals intersubgenotypic differences between genotypes 2a and 2b
    Naoya Sakamoto
    Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University, Tokyo, Japan
    J Med Virol 83:871-8. 2011
    ..In conclusion, IL-28B polymorphism affects responses to PEG-IFN-based treatment in difficult-to-treat HCV patients...
  18. doi request reprint A replication study confirmed the EDAR gene to be a major contributor to population differentiation regarding head hair thickness in Asia
    Akihiro Fujimoto
    Data Analysis Fusion Team, Computational Science Research Program, RIKEN, Tokyo, Japan
    Hum Genet 124:179-85. 2008
    ..8 x 10(-10)) than those of age, sex, and population. These results indicate that EDAR is the genetic determinant of hair thickness as well as a strong contributor to hair fiber thickness variation among Asian populations...
  19. pmc Evolutionary analysis of classical HLA class I and II genes suggests that recent positive selection acted on DPB1*04:01 in Japanese population
    Minae Kawashima
    Department of Human Genetics, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    PLoS ONE 7:e46806. 2012
    ..The selection coefficient of DPB1*04∶01 was estimated as 0.041 (95% credible interval 0.021-0.077). Our results suggest that DPB1*04∶01 has recently undergone strong positive selection in Japanese population...
  20. doi request reprint Relationship between polymorphisms of the inosine triphosphatase gene and anaemia or outcome after treatment with pegylated interferon and ribavirin
    Masayuki Kurosaki
    Division of Gastroenterology and Hepatology, Musashino Red Cross Hospital, Tokyo, Japan
    Antivir Ther 16:685-94. 2011
    ..The aim of this study was to replicate this finding in an independent Japanese cohort and to define a method to allow pretreatment prediction of anaemia in combination with other factors...
  21. doi request reprint Variant between CPT1B and CHKB associated with susceptibility to narcolepsy
    Taku Miyagawa
    Department of Human Genetics, Graduate School of Medicine, The University of Tokyo, Tokyo 113 0033, Japan
    Nat Genet 40:1324-8. 2008
    ....
  22. doi request reprint ITPA gene variant protects against anemia induced by pegylated interferon-α and ribavirin therapy for Japanese patients with chronic hepatitis C
    Naoya Sakamoto
    Department of Gastroenterology and Hepatology Department for Hepatitis Control, Tokyo Medical and Dental University, Tokyo, Japan
    Hepatol Res 40:1063-71. 2010
    ..In this study, we evaluated the clinical significance of ITPA variants in Japanese hepatitis C patients who were treated with pegylated interferon plus ribavirin...
  23. doi request reprint Replication of a genome-wide association study of panic disorder in a Japanese population
    Takeshi Otowa
    Department of Neuropsychiatry, The University of Tokyo, Japan
    J Hum Genet 55:91-6. 2010
    ..Our results failed to show any significant association with PD in these genes. Further studies on these variants with a larger sample size may be worth testing to confirm the results...
  24. pmc No association for Chinese HBV-related hepatocellular carcinoma susceptibility SNP in other East Asian populations
    Hiromi Sawai
    Department of Human Genetics, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, 113 0033, Japan
    BMC Med Genet 13:47. 2012
    ....
  25. doi request reprint The Q223R polymorphism in LEPR is associated with obesity in Pacific Islanders
    Takuro Furusawa
    Asian Studies Network ASNET, Division for International Relations, The University of Tokyo, Tokyo, Japan
    Hum Genet 127:287-94. 2010
    ..The 223Q allele was widely found among the AN-speaking study subjects, thus suggesting that the LEPR Q223R polymorphism is one of the factors contributing to the high prevalence of obesity in the Pacific Island populations...
  26. doi request reprint Pre-treatment prediction of response to pegylated-interferon plus ribavirin for chronic hepatitis C using genetic polymorphism in IL28B and viral factors
    Masayuki Kurosaki
    Division of Gastroenterology and Hepatology, Musashino Red Cross Hospital, Musashino shi, Tokyo, Japan
    J Hepatol 54:439-48. 2011
    ..Recent studies revealed an association between the IL28B genotype and treatment response. We aimed to develop a model for the pre-treatment prediction of response using host and viral factors...
  27. pmc Comparative analysis of copy number variation detection methods and database construction
    Asako Koike
    Central Research Laboratory, Hitachi Ltd, Tokyo, Japan
    BMC Genet 12:29. 2011
    ..Furthermore, we identified CNVs of 180 healthy Japanese individuals using parameters that showed the best performance in the HapMap data and investigated their characteristics...
  28. pmc Understanding of HLA-conferred susceptibility to chronic hepatitis B infection requires HLA genotyping-based association analysis
    Nao Nishida
    Department of Hepatic Disease, Research Center for Hepatitis and Immunology, National Center for Global Health and Medicine, Chiba 272 8516, Japan
    Sci Rep 6:24767. 2016
    ..The present study showed an example that SNP-based GWAS does not necessarily detect the primary susceptibility locus in the HLA region. ..
  29. doi request reprint Common variation in GPC5 is associated with acquired nephrotic syndrome
    Koji Okamoto
    Department of Nephrology and Endocrinology, University Hospital, The University of Tokyo, Tokyo, Japan
    Nat Genet 43:459-63. 2011
    ..This study identifies GPC5 as a new susceptibility gene for nephrotic syndrome and implicates GPC5 as a promising therapeutic target for reducing podocyte vulnerability in glomerular disease...
  30. doi request reprint Induction of IFN-λ3 as an additional effect of nucleotide, not nucleoside, analogues: a new potential target for HBV infection
    Kazumoto Murata
    The Research Center for Hepatitis and Immunology, National Center for Global Health and Medicine, Ichikawa, Japan
    Gut . 2016
    ..Thus, we measured IFN-λ3 levels in patients with HBV and investigated its clinical significance and association with nucleos(t)ide (NUC) analogue administration...
  31. doi request reprint Genome-wide association studies identify PRKCB as a novel genetic susceptibility locus for primary biliary cholangitis in the Japanese population
    Minae Kawashima
    Department of Human Genetics, Graduate School of Medicine, The University of Tokyo, Tokyo, 113 0033, Japan
    Hum Mol Genet . 2017
    ..These results may lead to improved understanding of the disease pathways involved in PBC, forming a basis for prevention of PBC and development of novel therapeutics...
  32. doi request reprint Genetic influences on prefrontal activation during a verbal fluency task in adults: a twin study based on multichannel near-infrared spectroscopy
    Eisuke Sakakibara
    Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan 2 Department of Psychiatry, National Center Hospital, National Center of Neurology and Psychiatry, Tokyo, Japan Electronic address
    Neuroimage 85:508-17. 2014
    ..This implies that the prefrontal hemodynamic dysfunction observed during an executive function task measured by NIRS may be an efficient endophenotype for large-scale imaging genetic studies in psychiatric disorders. ..
  33. pmc New susceptibility and resistance HLA-DP alleles to HBV-related diseases identified by a trans-ethnic association study in Asia
    Nao Nishida
    The Research Center for Hepatitis and Immunology, National Center for Global Health and Medicine, Ichikawa, Chiba, Japan Department of Human Genetics, Graduate School of Medicine, The University of Tokyo, Bunkyo ku, Tokyo, Japan
    PLoS ONE 9:e86449. 2014
    ..The present findings will serve as a base for future functional studies of HLA-DP molecules in order to understand the pathogenesis of HBV infection and the development of hepatocellular carcinoma...
  34. pmc IL28B polymorphisms and clinical implications for hepatitis C virus infection in Uzbekistan
    Dinara Khudayberganova
    Department of Hepatic Diseases, The Research Center for Hepatitis and Immunology, National Center for Global Health and Medicine, Ichikawa, Japan Institute of Virology, Ministry of Public Health of Uzbekistan, Tashkent, Uzbekistan
    PLoS ONE 9:e93011. 2014
    ..The aim of this study was to examine the prevalence and clinical significance of the outlined SNPs in a population from Central Asia, a multi-ethnic region with a developing economy and a high prevalence of HCV infection...
  35. doi request reprint Human primary biliary cirrhosis-susceptible allele of rs4979462 enhances TNFSF15 expression by binding NF-1
    Yuki Hitomi
    Department of Human Genetics, Graduate School of Medicine, The University of Tokyo, 7 3 1, Hongo, Bunkyo ku, Tokyo, 113 0033, Japan
    Hum Genet 134:737-47. 2015
    ..This study identified the causal variant for PBC susceptibility in the TNFSF15 locus and clarified its underlying molecular mechanism. TNFSF15 and NF-1 are considered to be potential targets for the treatment of PBC...
  36. doi request reprint Transcriptional regulation of endochondral ossification by HIF-2alpha during skeletal growth and osteoarthritis development
    Taku Saito
    Sensory and Motor System Medicine, University of Tokyo, Hongo, Bunkyo ku, Tokyo, Japan
    Nat Med 16:678-86. 2010
    ..Hence, HIF-2alpha is a central transactivator that targets several crucial genes for endochondral ossification and may represent a therapeutic target for osteoarthritis...
  37. ncbi request reprint [Development of genome-wide association database]
    Asako Koike
    Tanpakushitsu Kakusan Koso 53:882-7. 2008