Yusuke Nakamura

Summary

Affiliation: University of Tokyo
Country: Japan

Publications

  1. ncbi request reprint Isolation of p53-target genes and their functional analysis
    Yusuke Nakamura
    Laboratory of Molecular Medicine, Human Genome Center, The Institute of Medical Science, The University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Cancer Sci 95:7-11. 2004
  2. pmc VAV3 mediates resistance to breast cancer endocrine therapy
    Helena Aguilar
    Breast Cancer Res 16:R53. 2014
  3. pmc Genome-wide association study of pancreatic cancer in Japanese population
    Siew Kee Low
    Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, Department of Medical Genome Sciences, Graduate School of Frontier Scineces, The University of Tokyo, National Cancer Center Hospital, Tokyo, Japan
    PLoS ONE 5:e11824. 2010
  4. pmc Possible involvement of NEDD4 in keloid formation; its critical role in fibroblast proliferation and collagen production
    Suyoun Chung
    Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Japan
    Proc Jpn Acad Ser B Phys Biol Sci 87:563-73. 2011
  5. pmc Association of common variants in TNFRSF13B, TNFSF13, and ANXA3 with serum levels of non-albumin protein and immunoglobulin isotypes in Japanese
    Wael Osman
    Laboratory of Molecular Medicine, Institute of Medical Science, The University of Tokyo, Tokyo, Japan
    PLoS ONE 7:e32683. 2012
  6. pmc Multicenter, phase II clinical trial of cancer vaccination for advanced esophageal cancer with three peptides derived from novel cancer-testis antigens
    Koji Kono
    First Department of Surgery, University of Yamanashi, Yamanashi, Japan
    J Transl Med 10:141. 2012
  7. pmc Aromatase inhibitors, estrogens and musculoskeletal pain: estrogen-dependent T-cell leukemia 1A (TCL1A) gene-mediated regulation of cytokine expression
    Mohan Liu
    Division of Clinical Pharmacology, Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Breast Cancer Res 14:R41. 2012
  8. pmc No association for Chinese HBV-related hepatocellular carcinoma susceptibility SNP in other East Asian populations
    Hiromi Sawai
    Department of Human Genetics, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, 113 0033, Japan
    BMC Med Genet 13:47. 2012
  9. pmc Serum estradiol should be monitored not only during the peri-menopausal period but also the post-menopausal period at the time of aromatase inhibitor administration
    Taeko Nagao
    Department of Oncological and Regenerative Surgery, Institute of Health Biosciences, The University of Tokushima, Tokushima, Japan
    World J Surg Oncol 7:88. 2009
  10. pmc Deglycosylation and label-free quantitative LC-MALDI MS applied to efficient serum biomarker discovery of lung cancer
    Atsuhiko Toyama
    Laboratory for Biomarker Development, Center for Genomic Medicine, RIKEN, Tsurumiku Suehirocho1 7 22, Yokohama, Japan
    Proteome Sci 9:18. 2011

Detail Information

Publications163 found, 100 shown here

  1. ncbi request reprint Isolation of p53-target genes and their functional analysis
    Yusuke Nakamura
    Laboratory of Molecular Medicine, Human Genome Center, The Institute of Medical Science, The University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Cancer Sci 95:7-11. 2004
    ....
  2. pmc VAV3 mediates resistance to breast cancer endocrine therapy
    Helena Aguilar
    Breast Cancer Res 16:R53. 2014
    ..However, most tumors initially responsive to these therapies acquire resistance through mechanisms that involve ERα transcriptional regulatory plasticity. Herein we identify VAV3 as a critical component in this process...
  3. pmc Genome-wide association study of pancreatic cancer in Japanese population
    Siew Kee Low
    Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, Department of Medical Genome Sciences, Graduate School of Frontier Scineces, The University of Tokyo, National Cancer Center Hospital, Tokyo, Japan
    PLoS ONE 5:e11824. 2010
    ..3, 12p11.21 and 7q36.2, respectively. These associated SNPs are located within linkage disequilibrium blocks containing genes that have been implicated some roles in the oncogenesis of pancreatic cancer...
  4. pmc Possible involvement of NEDD4 in keloid formation; its critical role in fibroblast proliferation and collagen production
    Suyoun Chung
    Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Japan
    Proc Jpn Acad Ser B Phys Biol Sci 87:563-73. 2011
    ..Our findings provide new insights into mechanism developing keloid and can be applied for development of a novel treatment for keloid...
  5. pmc Association of common variants in TNFRSF13B, TNFSF13, and ANXA3 with serum levels of non-albumin protein and immunoglobulin isotypes in Japanese
    Wael Osman
    Laboratory of Molecular Medicine, Institute of Medical Science, The University of Tokyo, Tokyo, Japan
    PLoS ONE 7:e32683. 2012
    ..013). Rs10007186 in 4q21.2 was associated with serum levels of IgA (P = 0.036), IgM (P = 0.019), and IgE (P = 4.9 × 10(-4)). Our results should add interesting knowledge about the regulation of major serum components...
  6. pmc Multicenter, phase II clinical trial of cancer vaccination for advanced esophageal cancer with three peptides derived from novel cancer-testis antigens
    Koji Kono
    First Department of Surgery, University of Yamanashi, Yamanashi, Japan
    J Transl Med 10:141. 2012
    ....
  7. pmc Aromatase inhibitors, estrogens and musculoskeletal pain: estrogen-dependent T-cell leukemia 1A (TCL1A) gene-mediated regulation of cytokine expression
    Mohan Liu
    Division of Clinical Pharmacology, Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Breast Cancer Res 14:R41. 2012
    ..In the present study, we set out to determine whether these SNPs might influence cytokine expression and effect more widely, and, if so, to explore the mechanism of TCL1A-related AI-induced side effects...
  8. pmc No association for Chinese HBV-related hepatocellular carcinoma susceptibility SNP in other East Asian populations
    Hiromi Sawai
    Department of Human Genetics, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, 113 0033, Japan
    BMC Med Genet 13:47. 2012
    ....
  9. pmc Serum estradiol should be monitored not only during the peri-menopausal period but also the post-menopausal period at the time of aromatase inhibitor administration
    Taeko Nagao
    Department of Oncological and Regenerative Surgery, Institute of Health Biosciences, The University of Tokushima, Tokushima, Japan
    World J Surg Oncol 7:88. 2009
    ..However, there have been no reports of comprehensive monitoring of estradiol (E2) in breast cancer patients with ordinary menopause who were being administered AI...
  10. pmc Deglycosylation and label-free quantitative LC-MALDI MS applied to efficient serum biomarker discovery of lung cancer
    Atsuhiko Toyama
    Laboratory for Biomarker Development, Center for Genomic Medicine, RIKEN, Tsurumiku Suehirocho1 7 22, Yokohama, Japan
    Proteome Sci 9:18. 2011
    ..Here we investigated the effect of N-glycan and sialic acid removal from serum proteins on the performance of label-free quantification results...
  11. pmc Overexpression of the JmjC histone demethylase KDM5B in human carcinogenesis: involvement in the proliferation of cancer cells through the E2F/RB pathway
    Shinya Hayami
    Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo, 108 8639, Japan
    Mol Cancer 9:59. 2010
    ..Cell cycle-dependent characteristics of KDM5B were identified by immunofluorescence and FACS...
  12. pmc hzAnalyzer: detection, quantification, and visualization of contiguous homozygosity in high-density genotyping datasets
    Todd A Johnson
    Laboratory for Medical Informatics, Center for Genomic Medicine, RIKEN Yokohama Institute, Suehiro cho, Tsurumi ku, Yokohama, Kanagawa Ken, 230 0045, Japan
    Genome Biol 12:R21. 2011
    ....
  13. pmc Involvement of maternal embryonic leucine zipper kinase (MELK) in mammary carcinogenesis through interaction with Bcl-G, a pro-apoptotic member of the Bcl-2 family
    Meng Lay Lin
    Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan
    Breast Cancer Res 9:R17. 2007
    ..These side effects as well as drug resistance make it necessary to search for novel molecular targets for drugs on the basis of well-characterized mechanisms of action...
  14. pmc Linkage disequilibrium of evolutionarily conserved regions in the human genome
    Mamoru Kato
    SNP Research Center, RIKEN, Yokohama, Japan
    BMC Genomics 7:326. 2006
    ..To assess this hypothesis, we used genome-wide polymorphism data from the HapMap project and investigated LD within DNA sequences conserved between the human and mouse genomes...
  15. pmc Leptin as a critical regulator of hepatocellular carcinoma development through modulation of human telomerase reverse transcriptase
    Nikolaos Stefanou
    University of Thessaly, Medical School, Department of Biology, Larissa, Greece
    BMC Cancer 10:442. 2010
    ....
  16. ncbi request reprint VNTR (variable number of tandem repeat) sequences as transcriptional, translational, or functional regulators
    Y Nakamura
    Laboratory of Molecular Medicine, University of Tokyo, Japan
    J Hum Genet 43:149-52. 1998
    ..In this review, we summarize recent progress in efforts to clarify mechanisms involving VNTR sequences...
  17. ncbi request reprint Heterozygosities and allelic frequencies of 358 dinucleotide-repeat marker loci in the Japanese population
    Y Yamane-Tanaka
    Laboratory of Molecular Medicine, University of Tokyo, Japan
    J Hum Genet 43:165-8. 1998
    ..Therefore we have archived this database on a home page on the Internet (http:@www.ims.u-tokyo.ac.jp/nakamura/Yamane.html++ +)...
  18. ncbi request reprint Isolation and characterization of a novel serine threonine kinase gene on chromosome 3p22-21.3
    M Tamari
    Laboratory of Molecular Medicine, University of Tokyo, Japan
    J Hum Genet 44:116-20. 1999
    ..In view of its significant similarity to SOK1, we suspect that the novel gene, which we named OSR1, is a member of the SOK family of kinases in terms of function...
  19. doi request reprint DNA variations in human and medical genetics: 25 years of my experience
    Yusuke Nakamura
    Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan
    J Hum Genet 54:1-8. 2009
    ....
  20. doi request reprint Impact of LIMK1, MMP2 and TNF-α variations for intracranial aneurysm in Japanese population
    Siew Kee Low
    Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan
    J Hum Genet 56:211-6. 2011
    ..This study gave insights on the importance of stratified analysis between genders, and suggested that the underlying mechanism of IA pathogenesis might differ between females and males...
  21. pmc Personalizing carbamazepine therapy
    Taisei Mushiroda
    Research Group for Pharmacogenomics, RIKEN Center for Genomic Medicine, Yokohama 230 0045, Japan
    Genome Med 3:28. 2011
    ..These studies should aid future decision-making for personalized use of carbamazepine treatment...
  22. ncbi request reprint Identification of Myc-associated protein with JmjC domain as a novel therapeutic target oncogene for lung cancer
    Chie Suzuki
    Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, 4 6 1 Shirokanedai, Minato Ward, Tokyo 108 8639, Japan
    Mol Cancer Ther 6:542-51. 2007
    ....
  23. pmc WDRPUH, a novel WD-repeat-containing protein, is highly expressed in human hepatocellular carcinoma and involved in cell proliferation
    Fabio Pittella Silva
    Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan
    Neoplasia 7:348-55. 2005
    ..These findings have disclosed a novel insight into hepatocarcinogenesis and suggested that WDRPUH may be a molecular target for the development of new strategies to treat HCCs...
  24. ncbi request reprint Novel tumor marker REG4 detected in serum of patients with resectable pancreatic cancer and feasibility for antibody therapy targeting REG4
    Akio Takehara
    Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Cancer Sci 97:1191-7. 2006
    ..These findings indicate that REG4 is a promising tumor marker to screen early-stage PDAC, and also that neutralization of REG4 by the antibody may offer novel potential tools for the treatment of PDAC...
  25. ncbi request reprint Involvement of RQCD1 overexpression, a novel cancer-testis antigen, in the Akt pathway in breast cancer cells
    Masahiko Ajiro
    Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan
    Int J Oncol 35:673-81. 2009
    ..Our findings suggest that RQCD1 is a potential molecular target for treatment of breast cancer...
  26. pmc Histone lysine methyltransferase Wolf-Hirschhorn syndrome candidate 1 is involved in human carcinogenesis through regulation of the Wnt pathway
    Gouji Toyokawa
    Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, 4 6 1 Shirokanedai, Tokyo, Japan
    Neoplasia 13:887-98. 2011
    ....
  27. ncbi request reprint Identification of secernin 1 as a novel immunotherapy target for gastric cancer using the expression profiles of cDNA microarray
    Takako Suda
    Department of Surgery and Bioengineering, Institute of Medical Science, The University of Tokyo, 4 6 1, Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Cancer Sci 97:411-9. 2006
    ..These results strongly suggest that SCRN1 is a novel TAA and these peptides, both native and modified, may be applicable for cancer vaccines to treat gastric cancer...
  28. doi request reprint Involvement of G-patch domain containing 2 overexpression in breast carcinogenesis
    Meng Lay Lin
    Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan
    Cancer Sci 100:1443-50. 2009
    ....
  29. ncbi request reprint Oncogenic role of MPHOSPH1, a cancer-testis antigen specific to human bladder cancer
    Mitsugu Kanehira
    Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan
    Cancer Res 67:3276-85. 2007
    ..Our results imply that the MPHOSPH1/PRC1 complex is likely to play a crucial role in bladder carcinogenesis and that inhibition of the MPHOSPH1/PRC1 expression or their interaction should be novel therapeutic targets for bladder cancers...
  30. ncbi request reprint ANLN plays a critical role in human lung carcinogenesis through the activation of RHOA and by involvement in the phosphoinositide 3-kinase/AKT pathway
    Chie Suzuki
    Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Japan
    Cancer Res 65:11314-25. 2005
    ....
  31. doi request reprint Enhanced expression of RAD51 associating protein-1 is involved in the growth of intrahepatic cholangiocarcinoma cells
    Kazutaka Obama
    Laboratory of Molecular Medicine, Human Genome Center and Division of Clinical Genome Research, Institute of Medical Science, University of Tokyo, Tokyo, Japan
    Clin Cancer Res 14:1333-9. 2008
    ..Intrahepatic cholangiocarcinoma (ICC) is the second most common primary cancer in the liver, and its incidence is increasing in developed countries...
  32. doi request reprint Amino acid substitution in HCV core region and genetic variation near the IL28B gene affect viral dynamics during telaprevir, peginterferon and ribavirin treatment
    Norio Akuta
    Department of Hepatology, Toranomon Hospital, Tokyo, Japan
    Intervirology 55:417-25. 2012
    ....
  33. doi request reprint The histone methyltransferase Wolf-Hirschhorn syndrome candidate 1-like 1 (WHSC1L1) is involved in human carcinogenesis
    Daechun Kang
    Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Minato ku, Tokyo 108 8639, Japan
    Genes Chromosomes Cancer 52:126-39. 2013
    ..As WHSC1L1 expression is significantly low in various normal tissues including vital organs, WHSC1L1 could be a good candidate molecule for development of novel treatment for various types of cancer...
  34. ncbi request reprint Identification of ALDH4 as a p53-inducible gene and its protective role in cellular stresses
    Kyong Ah Yoon
    Human Genome Center, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    J Hum Genet 49:134-40. 2004
    ..These results suggest that p53 might play a protective role against cell damage induced by generation of intracellular ROS, through transcriptional activation of ALDH4...
  35. doi request reprint Involvement of the tubulin tyrosine ligase-like family member 4 polyglutamylase in PELP1 polyglutamylation and chromatin remodeling in pancreatic cancer cells
    Kotoe Kashiwaya
    Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan
    Cancer Res 70:4024-33. 2010
    ....
  36. ncbi request reprint EphA4 receptor, overexpressed in pancreatic ductal adenocarcinoma, promotes cancer cell growth
    Megumi Iiizumi
    Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Cancer Sci 97:1211-6. 2006
    ..These results suggest that the EphA4-ephrinA3 pathway is likely to be a promising molecular target for pancreatic cancer therapy...
  37. ncbi request reprint Validation study of the prediction system for clinical response of M-VAC neoadjuvant chemotherapy
    Ryo Takata
    Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo, Japan
    Cancer Sci 98:113-7. 2007
    ....
  38. doi request reprint Regulation of histone modification and chromatin structure by the p53-PADI4 pathway
    Chizu Tanikawa
    Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo 1088639, Japan
    Nat Commun 3:676. 2012
    ..Our findings reveal that cit-H4R3 may be an 'apoptotic histone code' to detect damaged cells and induce nuclear fragmentation, which has a crucial role in carcinogenesis...
  39. ncbi request reprint Isolation of development and differentiation enhancing factor-like 1 (DDEFL1) as a drug target for hepatocellular carcinomas
    Hiroshi Okabe
    Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Minato ku, Tokyo 108 8639, Japan
    Int J Oncol 24:43-8. 2004
    ..Our results provide novel insight into hepatocarcinogenesis and may contribute to development of new strategies for diagnosis and treatment of HCC...
  40. ncbi request reprint Identification of BMP and activin membrane-bound inhibitor (BAMBI), an inhibitor of transforming growth factor-beta signaling, as a target of the beta-catenin pathway in colorectal tumor cells
    Takashi Sekiya
    Laboratory of Molecular and Genetic Information, Institute of Molecular and Cellular Biosciences, University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 0032, Japan
    J Biol Chem 279:6840-6. 2004
    ..These results suggest that beta-catenin interferes with transforming growth factor-beta-mediated growth arrest by inducing the expression of BAMBI, and this may contribute to colorectal and hepatocellular tumorigenesis...
  41. ncbi request reprint Genes associated with liver metastasis of colon cancer, identified by genome-wide cDNA microarray
    Meihua Li
    Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Int J Oncol 24:305-12. 2004
    ..These data should contribute to a better understanding of the progression of colorectal tumors, and facilitate prediction of their metastatic potential...
  42. ncbi request reprint SMYD3 encodes a histone methyltransferase involved in the proliferation of cancer cells
    Ryuji Hamamoto
    Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Nat Cell Biol 6:731-40. 2004
    ..Furthermore, activation of SMYD3 may be a key factor in human carcinogenesis...
  43. ncbi request reprint Up-regulation of PSF2, a member of the GINS multiprotein complex, in intrahepatic cholangiocarcinoma
    Kazutaka Obama
    Laboratory of Molecular Medicine, Institute of Medical Science, The University of Tokyo, Minato ku, Tokyo 108 8639, Japan
    Oncol Rep 14:701-6. 2005
    ..The findings reported here provide new insights into human cholangiocarcinogenesis and may contribute to the development of novel therapeutic drugs for this type of liver cancer...
  44. ncbi request reprint The neuromedin U-growth hormone secretagogue receptor 1b/neurotensin receptor 1 oncogenic signaling pathway as a therapeutic target for lung cancer
    Koji Takahashi
    Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan
    Cancer Res 66:9408-19. 2006
    ..These data strongly implied that targeting the NMU signaling pathway would be a promising therapeutic strategy for the treatment of lung cancers...
  45. ncbi request reprint Cancer-testis antigen lymphocyte antigen 6 complex locus K is a serologic biomarker and a therapeutic target for lung and esophageal carcinomas
    Nobuhisa Ishikawa
    Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan
    Cancer Res 67:11601-11. 2007
    ..Our data imply that a cancer-testis antigen, LY6K, should be useful as a new type of tumor biomarker and probably as a target for the development of new molecular therapies for cancer treatment...
  46. doi request reprint Phosphorylation and activation of cell division cycle associated 5 by mitogen-activated protein kinase play a crucial role in human lung carcinogenesis
    Minh Hue Nguyen
    Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan
    Cancer Res 70:5337-47. 2010
    ....
  47. doi request reprint Critical roles of LGN/GPSM2 phosphorylation by PBK/TOPK in cell division of breast cancer cells
    Chikako Fukukawa
    Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan
    Genes Chromosomes Cancer 49:861-72. 2010
    ..These findings imply an important role of LGN/GPSM2 in cell division of breast cancer cells and suggest that the PBK/TOPK-LGN/GPSM2 pathway might be a promising molecular target for treatment of breast cancer...
  48. doi request reprint A genome-wide association study of HCV-induced liver cirrhosis in the Japanese population identifies novel susceptibility loci at the MHC region
    Yuji Urabe
    Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan
    J Hepatol 58:875-82. 2013
    ..We performed a genome-wide association study (GWAS) of hepatitis C virus (HCV)-induced liver cirrhosis (LC) to identify predictive biomarkers for the risk of LC in patients with chronic hepatitis C (CHC)...
  49. ncbi request reprint Catalog of 605 single-nucleotide polymorphisms (SNPs) among 13 genes encoding human ATP-binding cassette transporters: ABCA4, ABCA7, ABCA8, ABCD1, ABCD3, ABCD4, ABCE1, ABCF1, ABCG1, ABCG2, ABCG4, ABCG5, and ABCG8
    Aritoshi Iida
    Laboratory for Genotyping, RIKEN SNP Research Center, Tokyo, Japan
    J Hum Genet 47:285-310. 2002
    ..The high-density SNP maps we constructed on the basis of these data should provide useful information for investigating associations between genetic variations and common diseases or responsiveness to drug therapy...
  50. ncbi request reprint Gene-expression profiles of human tumor xenografts in nude mice treated orally with the EGFR tyrosine kinase inhibitor ZD1839
    Hitoshi Zembutsu
    Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Int J Oncol 23:29-39. 2003
    ....
  51. ncbi request reprint Identification of immunoglobulin superfamily 11 (IGSF11) as a novel target for cancer immunotherapy of gastrointestinal and hepatocellular carcinomas
    Takeshi Watanabe
    Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, 4 6 1, Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Cancer Sci 96:498-506. 2005
    ..These findings have provided a novel insight into carcinogenesis of the stomach, colon and liver, and will be helpful for the development of novel therapeutic strategies to a wide range of human cancers...
  52. ncbi request reprint Enhanced SMYD3 expression is essential for the growth of breast cancer cells
    Ryuji Hamamoto
    Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Cancer Sci 97:113-8. 2006
    ..These data imply that augmented SMYD3 expression plays a crucial role in breast carcinogenesis, and that inhibition of SMYD3 should be a novel therapeutic strategy for treatment of breast cancer...
  53. ncbi request reprint Fibroblast growth factor receptor 1 oncogene partner as a novel prognostic biomarker and therapeutic target for lung cancer
    Yuria Mano
    Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Cancer Sci 98:1902-13. 2007
    ..Because our data imply that FGFR1OP is likely to play a significant role in lung cancer growth and progression, FGFR1OP should be useful as a prognostic biomarker and probably as a therapeutic target for lung cancer...
  54. doi request reprint Activation of an estrogen/estrogen receptor signaling by BIG3 through its inhibitory effect on nuclear transport of PHB2/REA in breast cancer
    Jung Won Kim
    Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan
    Cancer Sci 100:1468-78. 2009
    ..Our results imply that BIG3 overexpression is one of the important mechanisms causing the activation of the estrogen/ERalpha signaling pathway in the hormone-related growth of breast cancer cells...
  55. doi request reprint Identification of nectin-4 oncoprotein as a diagnostic and therapeutic target for lung cancer
    Atsushi Takano
    Human Genome Center, Institute of Medical Science, The University of Tokyo, Japan
    Cancer Res 69:6694-703. 2009
    ..Nectin-4 might play a significant role in lung carcinogenesis, and it should be a new candidate serum and tissue biomarker, as well as a therapeutic target...
  56. doi request reprint Novel lipogenic enzyme ELOVL7 is involved in prostate cancer growth through saturated long-chain fatty acid metabolism
    Kenji Tamura
    Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan
    Cancer Res 69:8133-40. 2009
    ....
  57. doi request reprint Ubiquitination and downregulation of BRCA1 by ubiquitin-conjugating enzyme E2T overexpression in human breast cancer cells
    Tomomi Ueki
    Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan
    Cancer Res 69:8752-60. 2009
    ..Our data imply a critical role of UBE2T in development and/or progression of breast cancer through the interaction with and the regulation of the BRCA1/BARD1 complex...
  58. doi request reprint Activation of an oncogenic TBC1D7 (TBC1 domain family, member 7) protein in pulmonary carcinogenesis
    Nagato Sato
    Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan
    Genes Chromosomes Cancer 49:353-67. 2010
    ..Selective suppression of TBC1D7 and/or inhibition of the TBC1D7-TSC1 complex formation could be promising therapeutic strategies for lung cancer therapy...
  59. ncbi request reprint ADAM8 as a novel serological and histochemical marker for lung cancer
    Nobuhisa Ishikawa
    Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan
    Clin Cancer Res 10:8363-70. 2004
    ..Serum ADAM8 levels of 105 lung cancer patients and 72 controls were also measured by ELISA. A role of ADAM8 in cellular motility was examined by Matrigel assays...
  60. doi request reprint Genome-wide association study identifies five new susceptibility loci for prostate cancer in the Japanese population
    Ryo Takata
    Laboratory for Biomarker Development, Center of Genomic Medicine, RIKEN, Tokyo, Japan
    Nat Genet 42:751-4. 2010
    ..6 x 10(-8)). These findings advance our understanding of the genetic basis of prostate carcinogenesis and also highlight the genetic heterogeneity of prostate cancer susceptibility among different ethnic populations...
  61. doi request reprint A genome-wide association study identifies four susceptibility loci for keloid in the Japanese population
    Mitsuko Nakashima
    Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, University of Tokyo, Tokyo, Japan
    Nat Genet 42:768-71. 2010
    ..80 x 10(-13) (OR = 1.98). Association of rs8032158 located in NEDD4 on chromosome 15 yielded P = 5.96 x 10(-13) (OR = 1.51). Our findings provide new insights into the pathophysiology of keloid formation...
  62. ncbi request reprint Plakophilin 3 oncogene as prognostic marker and therapeutic target for lung cancer
    Chiyuki Furukawa
    Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo
    Cancer Res 65:7102-10. 2005
    ....
  63. doi request reprint Identification of a functional variant in SPLUNC1 associated with nasopharyngeal carcinoma susceptibility among Malaysian Chinese
    Poh Yin Yew
    Laboratory for International Alliance, RIKEN Center for Genomic Medicine, Tsurumi ku, Yokohama, Japan
    Mol Carcinog 51:E74-82. 2012
    ..In summary, our study suggested that rs1407019 in intronic enhancer of SPLUNC1 is associated with NPC susceptibility in which its A allele confers an increased risk of NPC in the Malaysian Chinese population...
  64. doi request reprint Chondrolectin is a novel diagnostic biomarker and a therapeutic target for lung cancer
    Ken Masuda
    Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan
    Clin Cancer Res 17:7712-22. 2011
    ..This study aims to identify molecules that might be useful as diagnostic/prognostic biomarkers and as targets for the development of new molecular therapies for lung cancer...
  65. ncbi request reprint Functional variation in LGALS2 confers risk of myocardial infarction and regulates lymphotoxin-alpha secretion in vitro
    Kouichi Ozaki
    Laboratory for Cardiovascular Diseases, SNP Research Center, The Institute of Physical and Chemical Research RIKEN, Tokyo 108 8639, Japan
    Nature 429:72-5. 2004
    ..Smooth muscle cells and macrophages in the human atherosclerotic lesions expressed both galectin-2 and LTA. Our findings thus suggest a link between the LTA cascade and the pathogenesis of MI...
  66. ncbi request reprint Oncogenic role of NALP7 in testicular seminomas
    Koichi Okada
    Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo 108 8639, Japan
    Cancer Sci 95:949-54. 2004
    ..These findings imply that NALP7 may play a crucial role in cell proliferation, as well as testicular tumorigenesis, and it appears to be a promising candidate for development of targeted therapy for TGCTs...
  67. ncbi request reprint Genome-wide gene expression profiles of clear cell renal cell carcinoma: identification of molecular targets for treatment of renal cell carcinoma
    Eiji Hirota
    Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo 108 8639, Japan
    Int J Oncol 29:799-827. 2006
    ..In conclusion, our data should be helpful for a better understanding of the tumorigenesis of RCC and should contribute to the development of diagnostic tumor markers and molecular-targeting therapy for patients with RCC...
  68. ncbi request reprint Identification of a novel non-coding RNA, MIAT, that confers risk of myocardial infarction
    Nobuaki Ishii
    Laboratory for Cardiovascular Diseases, SNP Research Center, The Institute of Physical and Chemical Research RIKEN, 4 6 1 Shirokanedai, Minato ku, Tokyo, 108 8639, Japan
    J Hum Genet 51:1087-99. 2006
    ..Moreover, unidentified nuclear protein(s) bound more intensely to risk allele than non-risk allele. These results indicate that the altered expression of MIAT by the SNP may play some role in the pathogenesis of MI...
  69. ncbi request reprint Involvement of kinesin family member 2C/mitotic centromere-associated kinesin overexpression in mammary carcinogenesis
    Arata Shimo
    Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Cancer Sci 99:62-70. 2008
    ..These findings suggest that overexpression of KIF2C/MCAK might be involved in breast carcinogenesis and is a promising therapeutic target for breast cancers...
  70. ncbi request reprint Involvement of TMEM22 overexpression in the growth of renal cell carcinoma cells
    Sachiko Dobashi
    Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo 108 8639, Japan
    Oncol Rep 21:305-12. 2009
    ..Our results imply that the TMEM22/RAB37 complex is likely to play a crucial role in growth of RCC and that inhibition of the TMEM22/RAB37 expression or their interaction should be novel therapeutic targets for RCC...
  71. doi request reprint Identification of C2orf18, termed ANT2BP (ANT2-binding protein), as one of the key molecules involved in pancreatic carcinogenesis
    Kotoe Kashiwaya
    Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan
    Cancer Sci 100:457-64. 2009
    ..These findings implicated that C2orf18, termed ANT2-binding protein (ANT2BP), might serve as a candidate molecular target for pancreatic cancer therapy...
  72. doi request reprint Association study of genetic polymorphism in ABCC4 with cyclophosphamide-induced adverse drug reactions in breast cancer patients
    Siew Kee Low
    Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan
    J Hum Genet 54:564-71. 2009
    ..00028; OR=3.13). The SNPs in ABCC4 might be applicable in predicting the risk of ADRs in patients receiving CPA combination chemotherapy...
  73. doi request reprint C12orf48, termed PARP-1 binding protein, enhances poly(ADP-ribose) polymerase-1 (PARP-1) activity and protects pancreatic cancer cells from DNA damage
    Lianhua Piao
    Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan
    Genes Chromosomes Cancer 50:13-24. 2011
    ..Hence, our findings implicate C12orf48, termed PARP-1 binding protein (PARPBP), or its interaction with PARP-1 to be a potential molecular target for development of selective therapy for pancreatic cancer...
  74. doi request reprint Association between HLA-B*4001 and lipodystrophy among HIV-infected patients from Thailand who received a stavudine-containing antiretroviral regimen
    Wittaya Wangsomboonsiri
    Departments of Medicine, University of Tokyo, Tokyo, Japan
    Clin Infect Dis 50:597-604. 2010
    ..The aim of this study was to determine the clinical risk factors and human leukocyte antigen (HLA) alleles associated with stavudine-associated lipodystrophy...
  75. ncbi request reprint Activation of KIF4A as a prognostic biomarker and therapeutic target for lung cancer
    Masaya Taniwaki
    Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, 4 6 1 Shirokanedai, Minato Ward, Tokyo, Japan
    Clin Cancer Res 13:6624-31. 2007
    ..A role of KIF4A in cancer cell growth and/or survival was examined by small interfering RNA experiments. Cellular invasive activity of KIF4A on mammalian cells was examined using Matrigel assays...
  76. ncbi request reprint Characterization of SEZ6L2 cell-surface protein as a novel prognostic marker for lung cancer
    Nobuhisa Ishikawa
    Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Cancer Sci 97:737-45. 2006
    ..These results indicate that SEZ6L2 should be a useful prognostic marker of lung cancers...
  77. doi request reprint The JmjC domain-containing histone demethylase KDM3A is a positive regulator of the G1/S transition in cancer cells via transcriptional regulation of the HOXA1 gene
    Hyun Soo Cho
    Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo, Japan
    Int J Cancer 131:E179-89. 2012
    ..Together, our results suggest that elevated expression of KDM3A plays a critical role in the growth of cancer cells, and further studies may reveal a cancer therapeutic potential in KDM3A inhibition...
  78. pmc Minichromosome Maintenance Protein 7 is a potential therapeutic target in human cancer and a novel prognostic marker of non-small cell lung cancer
    Gouji Toyokawa
    Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Mol Cancer 10:65. 2011
    ..This can only be achieved if the drug used is against a specific target located in the tumor cells. In this study, we evaluated Minichromosome Maintenance Protein 7 (MCM7) as a novel therapeutic target in cancer...
  79. ncbi request reprint Functional SNPs in the lymphotoxin-alpha gene that are associated with susceptibility to myocardial infarction
    Kouichi Ozaki
    Laboratory for Cardiovascular Diseases, SNP Research Center, The Institute of Physical and Chemical Research RIKEN, 4 6 1, Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Nat Genet 32:650-4. 2002
    ..Moreover, the SNP, in intron 1 of LTA, enhanced the transcriptional level of LTA. These results indicate that variants in the LTA are risk factors for myocardial infraction and implicate LTA in the pathogenesis of the disorder...
  80. ncbi request reprint Involvement of the FGF18 gene in colorectal carcinogenesis, as a novel downstream target of the beta-catenin/T-cell factor complex
    Takashi Shimokawa
    Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Cancer Res 63:6116-20. 2003
    ....
  81. ncbi request reprint Down-regulation of RAB6KIFL/KIF20A, a kinesin involved with membrane trafficking of discs large homologue 5, can attenuate growth of pancreatic cancer cell
    Keisuke Taniuchi
    Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, University of Tokyo, Tokyo, Japan
    Cancer Res 65:105-12. 2005
    ..Our results imply that collaboration of RAB6KIFL and DLG5 is likely to be involved in pancreatic carcinogenesis. These molecules should be promising targets for development of new therapeutic strategies for PDACs...
  82. ncbi request reprint Genome-wide gene expression profile analysis of esophageal squamous cell carcinomas
    Takumi Yamabuki
    Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo 108 8639, Japan
    Int J Oncol 28:1375-84. 2006
    ....
  83. ncbi request reprint A functional SNP in PSMA6 confers risk of myocardial infarction in the Japanese population
    Kouichi Ozaki
    Laboratory for Cardiovascular Diseases, SNP Research Center, The Institute of Physical and Chemical Research RIKEN, 4 6 1, Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Nat Genet 38:921-5. 2006
    ..Our results implicate this PSMA6 SNP as a previously unknown genetic risk factor for myocardial infarction...
  84. ncbi request reprint Gene expression profiles of small-cell lung cancers: molecular signatures of lung cancer
    Masaya Taniwaki
    Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo 108 8639, Japan
    Int J Oncol 29:567-75. 2006
    ..Our data provide valuable information for better understanding of lung carcinogenesis and chemoresistance...
  85. doi request reprint A functional SNP in the NKX2.5-binding site of ITPR3 promoter is associated with susceptibility to systemic lupus erythematosus in Japanese population
    Tetsuya Oishi
    Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, 4 6 1 Shirokanedai, Minato, Tokyo, 108 8639, Japan
    J Hum Genet 53:151-62. 2008
    ..Individuals with risk genotype of both ITPR3 and NKX2.5 loci have higher risk for SLE (odds ratio=5.77). Our data demonstrate that genetic and functional interactions of ITPR3 and NKX2.5 play a crucial role in the pathogenesis of SLE...
  86. doi request reprint Functional variants in ADH1B and ALDH2 coupled with alcohol and smoking synergistically enhance esophageal cancer risk
    Ri Cui
    Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, University of Tokyo, Tokyo, Japan
    Gastroenterology 137:1768-75. 2009
    ..Therefore, identification of epidemiologic factors that influence the development of ESCC would facilitate prevention and/or early detection of the disease...
  87. doi request reprint Influence of ITPA polymorphisms on decreases of hemoglobin during treatment with pegylated interferon, ribavirin, and telaprevir
    Fumitaka Suzuki
    Department of Hepatology, Toranomon Hospital, Tokyo, Japan
    Hepatology 53:415-21. 2011
    ..039), but the total RBV dose was no different between them (49 ± 17% and 54 ± 18% of the target, P = 0.531). Sustained virological response (SVR) was achieved in 70% and 64% of them, respectively (P = 0.724)...
  88. ncbi request reprint [BioBank Japan project]
    Yozo Ohnishi
    Laboratory of Molecular Medicine, Institute of Medical Science, University of Tokyo
    Nihon Rinsho 63:35-41. 2005
  89. ncbi request reprint SLC22A4 polymorphism and rheumatoid arthritis susceptibility: a replication study in a Japanese population and a metaanalysis
    Yukinori Okada
    Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan
    J Rheumatol 35:1723-8. 2008
    ..We assessed the RA susceptibility of slc2F1/F2 polymorphisms...
  90. pmc A single nucleotide polymorphism within the acetyl-coenzyme A carboxylase beta gene is associated with proteinuria in patients with type 2 diabetes
    Shiro Maeda
    Laboratory for Endocrinology and Metabolism, RIKEN Center for Genomic Medicine, Yokohama, Kanagawa, Japan
    PLoS Genet 6:e1000842. 2010
    ..These results suggest that ACACB is a strong candidate for conferring susceptibility for proteinuria in patients with type 2 diabetes...
  91. pmc Replication study for the association between four Loci identified by a genome-wide association study on European American subjects with type 1 diabetes and susceptibility to diabetic nephropathy in Japanese subjects with type 2 diabetes
    Shiro Maeda
    Laboratory for Endocrinology and Metabolism, RIKEN Center for Genomic Medicine, Yokohama, Japan
    Diabetes 59:2075-9. 2010
    ..In this study, we determined the association of the four loci with diabetic nephropathy in Japanese subjects with type 2 diabetes...
  92. ncbi request reprint Genome-wide cDNA microarray screening to correlate gene expression profiles with sensitivity of 85 human cancer xenografts to anticancer drugs
    Hitoshi Zembutsu
    Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo 108 8639, Japan
    Cancer Res 62:518-27. 2002
    ....
  93. ncbi request reprint Thirteen single-nucleotide polymorphisms (SNPs) in the alcohol dehydrogenase 4 (ADH4) gene locus
    Aritoshi Iida
    RIKEN SNP Research Center, Institute of Medical Science, The University of Tokyo, Japan
    J Hum Genet 47:74-6. 2002
    ..Our SNP map presented here should provide tools to evaluate the role of ADH4 in complex genetic diseases and a variety of pharmacogenetic effects...
  94. ncbi request reprint Single-nucleotide polymorphisms in the class II region of the major histocompatibility complex in Japanese patients with immunoglobulin A nephropathy
    Fumihiro Akiyama
    Human Genome Center, The Institute of Medical Science, University of Tokyo, Japan
    J Hum Genet 47:532-8. 2002
    ..000001, odds ratio = 1.91 [95% confidence interval 1.46-2.49]); SNPs in other LD blocks were not. Our data imply that some haplotype of the HLA- DRA locus has an important role in the development of IgAN in Japanese patients...
  95. ncbi request reprint Prediction of sensitivity to STI571 among chronic myeloid leukemia patients by genome-wide cDNA microarray analysis
    Yasuyuki Kaneta
    Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Minato ku, Tokyo 108 8639, Japan
    Jpn J Cancer Res 93:849-56. 2002
    ..These results provide the first evidence that gene-expression profiles can predict sensitivity of CML cells to STI571, and may eventually lead to the achievement of "personalized therapy" for this disease...
  96. ncbi request reprint Predicting response to methotrexate, vinblastine, doxorubicin, and cisplatin neoadjuvant chemotherapy for bladder cancers through genome-wide gene expression profiling
    Ryo Takata
    Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan
    Clin Cancer Res 11:2625-36. 2005
    ..Our purpose in this study is to establish a method for predicting response to the M-VAC therapy...
  97. ncbi request reprint Single nucleotide polymorphisms in TNFSF15 confer susceptibility to Crohn's disease
    Keiko Yamazaki
    Laboratory of Molecular Medicine, Institute of Medical Science, The University of Tokyo, Japan
    Hum Mol Genet 14:3499-506. 2005
    ..Our results suggest that the genetic variations in the TNFSF15 gene contribute to the susceptibility to IBD in the Japanese and European populations...
  98. ncbi request reprint A nonsynonymous SNP in PRKCH (protein kinase C eta) increases the risk of cerebral infarction
    Michiaki Kubo
    Department of Environmental Medicine, Kyushu University, Fukuoka 812 8582, Japan
    Nat Genet 39:212-7. 2007
    ..Our results support a role for PRKCH in the pathogenesis of cerebral infarction...
  99. ncbi request reprint Molecular features of hormone-refractory prostate cancer cells by genome-wide gene expression profiles
    Kenji Tamura
    Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan
    Cancer Res 67:5117-25. 2007
    ..Our microarray analysis of HRPC cells should provide useful information to understand the molecular mechanism of HRPC progression and to identify molecular targets for development of HRPC treatment...
  100. ncbi request reprint Prediction of risk of disease recurrence by genome-wide cDNA microarray analysis in patients with Philadelphia chromosome-positive acute lymphoblastic leukemia treated with imatinib-combined chemotherapy
    Hitoshi Zembutsu
    Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo 108 8639, Japan
    Int J Oncol 31:313-22. 2007
    ..Our results suggest that achievement of continuous response with imatinib-combined chemotherapy can be predicted by expression patterns in this set of genes, leading to achievement of 'personalized therapy' for treatment of this disease...
  101. doi request reprint The association of a nonsynonymous single-nucleotide polymorphism in TNFAIP3 with systemic lupus erythematosus and rheumatoid arthritis in the Japanese population
    Kenichi Shimane
    Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Arthritis Rheum 62:574-9. 2010
    ..The aim of this study was to assess the role of TNFAIP3 in the development of SLE and RA in Japanese subjects...