Mikihiko Naito

Summary

Affiliation: University of Tokyo
Country: Japan

Publications

  1. ncbi request reprint [Inhibition of apoptosis by a huge UBC protein, Apollon/BRUCE/BIRC6]
    Mikihiko Naito
    Tanpakushitsu Kakusan Koso 51:1391-4. 2006
  2. pmc Cellular FLIP inhibits beta-catenin ubiquitylation and enhances Wnt signaling
    Mikihiko Naito
    Institute of Molecular and Cellular Biosciences, The University of Tokyo, Yayoi, Bunkyo ku, Tokyo 113 0032, Japan
    Mol Cell Biol 24:8418-27. 2004
  3. ncbi request reprint Caspase-independent necrotic cell death induced by a radiosensitizer, 8-nitrocaffeine
    Mikihiko Naito
    Institute of Molecular and Cellular Biosciences, The University of Tokyo, Bunkyo ku, Tokyo 113 0032, Japan
    Cancer Sci 95:361-6. 2004
  4. doi request reprint Small molecules destabilize cIAP1 by activating auto-ubiquitylation
    Keiko Sekine
    Institute of Molecular and Cellular Biosciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo, Japan
    J Biol Chem 283:8961-8. 2008
  5. ncbi request reprint HtrA2 cleaves Apollon and induces cell death by IAP-binding motif in Apollon-deficient cells
    Keiko Sekine
    Institute of Molecular and Cellular Biosciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 0032, Japan
    Biochem Biophys Res Commun 330:279-85. 2005
  6. ncbi request reprint Impairment of the ubiquitin-proteasome system by cellular FLIP
    Toshiyasu Ishioka
    Institute of Molecular and Cellular Biosciences, The University of Tokyo, Bunkyo ku, Tokyo 113 0032, Japan
    Genes Cells 12:735-44. 2007
  7. ncbi request reprint Apollon ubiquitinates SMAC and caspase-9, and has an essential cytoprotection function
    Yanyan Hao
    Institute of Molecular and Cellular Biosciences, The University of Tokyo, 1 1 1, Yayoi, Bunkyo ku, Tokyo 113 0032, Japan
    Nat Cell Biol 6:849-60. 2004
  8. doi request reprint Double protein knockdown of cIAP1 and CRABP-II using a hybrid molecule consisting of ATRA and IAPs antagonist
    Yukihiro Itoh
    Institute of Molecular and Cellular Biosciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 0032, Japan
    Bioorg Med Chem Lett 22:4453-7. 2012
  9. doi request reprint Modulation of Wnt signaling by the nuclear localization of cellular FLIP-L
    Ryohei Katayama
    Institute of Molecular and Cellular Biosciences, The University of Tokyo, Bunkyo ku, Tokyo 113 0032, Japan
    J Cell Sci 123:23-8. 2010
  10. doi request reprint Degradation-promoters of cellular inhibitor of apoptosis protein 1 based on bestatin and actinonin
    Shinichi Sato
    Institute of Molecular and Cellular Biosciences, The University of Tokyo, 1 1 1 Yayoi, Tokyo 113 0032, Japan
    Bioorg Med Chem 16:4685-98. 2008

Collaborators

Detail Information

Publications41

  1. ncbi request reprint [Inhibition of apoptosis by a huge UBC protein, Apollon/BRUCE/BIRC6]
    Mikihiko Naito
    Tanpakushitsu Kakusan Koso 51:1391-4. 2006
  2. pmc Cellular FLIP inhibits beta-catenin ubiquitylation and enhances Wnt signaling
    Mikihiko Naito
    Institute of Molecular and Cellular Biosciences, The University of Tokyo, Yayoi, Bunkyo ku, Tokyo 113 0032, Japan
    Mol Cell Biol 24:8418-27. 2004
    ....
  3. ncbi request reprint Caspase-independent necrotic cell death induced by a radiosensitizer, 8-nitrocaffeine
    Mikihiko Naito
    Institute of Molecular and Cellular Biosciences, The University of Tokyo, Bunkyo ku, Tokyo 113 0032, Japan
    Cancer Sci 95:361-6. 2004
    ..Since cancer cells are often derived from a selected population of cells resistant to apoptosis, inducers of necrotic cell death could be beneficial to kill cancer cells that have acquired resistance to apoptosis-induction therapy...
  4. doi request reprint Small molecules destabilize cIAP1 by activating auto-ubiquitylation
    Keiko Sekine
    Institute of Molecular and Cellular Biosciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo, Japan
    J Biol Chem 283:8961-8. 2008
    ..Manipulation of the intrinsic ubiquitin-ligase activity could be a novel strategy to develop small molecules for therapeutic purposes...
  5. ncbi request reprint HtrA2 cleaves Apollon and induces cell death by IAP-binding motif in Apollon-deficient cells
    Keiko Sekine
    Institute of Molecular and Cellular Biosciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 0032, Japan
    Biochem Biophys Res Commun 330:279-85. 2005
    ..These results indicate that HtrA2 induces apoptosis in two different mechanisms, one with serine protease domain and the other with IAP-binding motif, in Apollon-deficient cells...
  6. ncbi request reprint Impairment of the ubiquitin-proteasome system by cellular FLIP
    Toshiyasu Ishioka
    Institute of Molecular and Cellular Biosciences, The University of Tokyo, Bunkyo ku, Tokyo 113 0032, Japan
    Genes Cells 12:735-44. 2007
    ..These results suggest that cFLIP-L is prone to aggregate and impairs UPS function, which could be involved in the pathological function of cFLIP-L expressed in certain cancer cells...
  7. ncbi request reprint Apollon ubiquitinates SMAC and caspase-9, and has an essential cytoprotection function
    Yanyan Hao
    Institute of Molecular and Cellular Biosciences, The University of Tokyo, 1 1 1, Yayoi, Bunkyo ku, Tokyo 113 0032, Japan
    Nat Cell Biol 6:849-60. 2004
    ..Furthermore, the IAP-binding motif of SMAC was required to induce apoptosis in Apollon-deficient cells. These results suggest that Apollon has an essential function in preventing SMAC-induced apoptosis...
  8. doi request reprint Double protein knockdown of cIAP1 and CRABP-II using a hybrid molecule consisting of ATRA and IAPs antagonist
    Yukihiro Itoh
    Institute of Molecular and Cellular Biosciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 0032, Japan
    Bioorg Med Chem Lett 22:4453-7. 2012
    ..It showed potently inhibited the proliferation of IMR32 cells...
  9. doi request reprint Modulation of Wnt signaling by the nuclear localization of cellular FLIP-L
    Ryohei Katayama
    Institute of Molecular and Cellular Biosciences, The University of Tokyo, Bunkyo ku, Tokyo 113 0032, Japan
    J Cell Sci 123:23-8. 2010
    ..cFLIP-L physically interacts with the reporter plasmid for Wnt signaling, but not with the control plasmid. These results suggest a role for nuclear cFLIP-L in the modulation of Wnt signaling...
  10. doi request reprint Degradation-promoters of cellular inhibitor of apoptosis protein 1 based on bestatin and actinonin
    Shinichi Sato
    Institute of Molecular and Cellular Biosciences, The University of Tokyo, 1 1 1 Yayoi, Tokyo 113 0032, Japan
    Bioorg Med Chem 16:4685-98. 2008
    ..HAB-5A (30b) showed the most potent activity (IC(50)=0.53 microM) among the compounds prepared...
  11. ncbi request reprint Effects of various methoxyflavones on vincristine uptake and multidrug resistance to vincristine in P-gp-overexpressing K562/ADM cells
    Hisakazu Ohtani
    Laboratory of Drug Informatics, Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7 3 1, Hongo, Bunkyo ku, Tokyo, 113 0033, Japan
    Pharm Res 24:1936-43. 2007
    ..Some methoxyflavones (MFs) are known to inhibit the function of P-glycoprotein. The aim of this study is to characterize the reversal of multidrug resistance (MDR) by MFs...
  12. doi request reprint Demonstration of direct binding of cIAP1 degradation-promoting bestatin analogs to BIR3 domain: Synthesis and application of fluorescent bestatin ester analogs
    Shinichi Sato
    Institute of Molecular and Cellular Biosciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 0032, Japan
    Bioorg Med Chem Lett 18:3354-8. 2008
    ..Herein, we present chemical evidence that bestatin ester analogs directly interact with the cIAP1-BIR3 domain by means of fluorescence polarization assay and photoaffinity labeling assay using fluorescent probes...
  13. doi request reprint Design, synthesis and biological evaluation of nuclear receptor-degradation inducers
    Yukihiro Itoh
    Institute of Molecular and Cellular Biosciences, The University of Tokyo, Bunkyo ku, Tokyo, Japan
    Bioorg Med Chem 19:6768-78. 2011
    ..These newly synthesized RAR, ER, and AR SNIPERs, 9, 11, and 13, respectively, were confirmed to significantly reduce the levels of the corresponding NRs in live cells...
  14. doi request reprint Modulation of RIP1 ubiquitylation and distribution by MeBS to sensitize cancer cells to tumor necrosis factor α-induced apoptosis
    Seungseob Kim
    National Institute of Health Sciences, Tokyo Graduate School of Frontier Sciences, The University of Tokyo, Chiba, Japan
    Cancer Sci 101:2425-9. 2010
    ..These results indicate an important role of RIP1 in apoptosis induced by combined treatment with TNFα and MeBS, suggesting that MeBS sensitizes cancer cells to apoptosis by modulating RIP1 ubiquitylation and distribution...
  15. ncbi request reprint [Screening for apoptosis inducers]
    Mikihiko Naito
    Institute of Molecular and Cellular Biosciences, University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 0032, Japan
    Gan To Kagaku Ryoho 31:522-5. 2004
    ..In the screening, we found that 8-nitrocaffeine induces cell death distinct from typical apoptosis. Morphological and biochemical analysis revealed that reactive oxygen species mediates the 8-nitrocaffeine-induced necrotic cell death...
  16. ncbi request reprint Molecular targeting therapy of cancer: drug resistance, apoptosis and survival signal
    Takashi Tsuruo
    Institute of Molecular and Cellular Biosciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 0032
    Cancer Sci 94:15-21. 2003
    ..Our present studies provide novel targets for future effective molecular cancer therapeutics...
  17. ncbi request reprint [Molecular mechanism of apoptosis inhibition by IAPs and its implication to cancer therapy]
    Mikihiko Naito
    Institute of Molecular and Cellular Biosciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 0032, Japan
    Seikagaku 78:525-8. 2006
  18. doi request reprint Protein knockdown using methyl bestatin-ligand hybrid molecules: design and synthesis of inducers of ubiquitination-mediated degradation of cellular retinoic acid-binding proteins
    Yukihiro Itoh
    Institute of Molecular and Cellular Biosciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 0032, Japan
    J Am Chem Soc 132:5820-6. 2010
    ..Hybrid molecules such as 4 should be useful not only as chemical tools for studying the biological/physiological functions of CRABPs but also as candidate therapeutic agents targeting CRABPs...
  19. doi request reprint Development of target protein-selective degradation inducer for protein knockdown
    Yukihiro Itoh
    Institute of Molecular and Cellular Biosciences, The University of Tokyo, Yayoi, Bunkyo ku, Japan
    Bioorg Med Chem 19:3229-41. 2011
    ..Such small-molecular, amide-type SNIPERs that induce target protein-selective degradation without affecting IAPs should be effective tools to study the biological roles of target proteins in living cells...
  20. ncbi request reprint Cell differentiation inducers derived from thalidomide
    Tomomi Noguchi
    Institute of Molecular and Cellular Biosciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 0032, Japan
    Bioorg Med Chem Lett 15:3212-5. 2005
    ..5-Hydroxy- and 4-amino-2-(2,6-diisopropylphenyl)-1H-isoindole-1,3-dione (5HPP-33 and 4APP-33, respectively) have been shown to possess cell differentiation-inducing activity toward human leukemia cell line HL-60...
  21. doi request reprint Degradation of HaloTag-fused nuclear proteins using bestatin-HaloTag ligand hybrid molecules
    Shusuke Tomoshige
    Institute of Molecular and Cellular Biosciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 0032, Japan
    Org Biomol Chem 13:9746-50. 2015
    ..HaloTag-binding degradation inducers can be synthesized easily, and are expected to be useful as biological tools for pan-degradation of HaloTag-fused proteins...
  22. ncbi request reprint Induction of mammalian cell death by a plant Bax inhibitor
    Li Hua Yu
    Institute of Molecular and Cellular Biosciences, University of Tokyo, Yayoi 1 1 1, Bunkyo ku, 113 0032, Tokyo, Japan
    FEBS Lett 512:308-12. 2002
    ..The proapoptotic effect of AtBI-1 was blocked by the X-linked caspase inhibitor XIAP, suggesting that the cell death caused by AtBI-1 is similar to that caused by Bax...
  23. ncbi request reprint MS-209, a quinoline-type reversal agent, potentiates antitumor efficacy of docetaxel in multidrug-resistant solid tumor xenograft models
    Mikihiko Naito
    Institute of Molecular and Cellular Biosciences, The University of Tokyo, Bunkyo ku, Tokyo 113 0032
    Clin Cancer Res 8:582-8. 2002
    ..These results indicate that MS-209 could be a clinically useful drug to modulate MDR in docetaxel therapy...
  24. ncbi request reprint Enhancement of L-cystine transport activity and its relation to xCT gene induction at the blood-brain barrier by diethyl maleate treatment
    Ken ichi Hosoya
    Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, Toyama, Japan
    J Pharmacol Exp Ther 302:225-31. 2002
    ..L-Cystine transport via system x(c)(-) at the BBB is likely to be induced under oxidative stress conditions following DEM treatment due to enhanced transcription of the xCT gene...
  25. doi request reprint Tetraspanin family member CD9 inhibits Aggrus/podoplanin-induced platelet aggregation and suppresses pulmonary metastasis
    Youya Nakazawa
    Cancer Chemotherapy Center, Japanese Foundation for Cancer Research, Tokyo
    Blood 112:1730-9. 2008
    ..Therefore, CD9 may act as a metastasis suppressor, at least in part, by neutralizing Aggrus-mediated platelet aggregation...
  26. pmc Freud-1/Aki1, a novel PDK1-interacting protein, functions as a scaffold to activate the PDK1/Akt pathway in epidermal growth factor signaling
    Akito Nakamura
    Cancer Chemotherapy Center, Japanese Foundation for Cancer Research, Tokyo 135 8550, Japan
    Mol Cell Biol 28:5996-6009. 2008
    ..Our results suggest that Freud-1/Aki1 is a novel receptor-selective scaffold protein for the PDK1/Akt pathway and present a new activation mechanism of Akt...
  27. ncbi request reprint Hypoxia up-regulates glyceraldehyde-3-phosphate dehydrogenase in mouse brain capillary endothelial cells: involvement of Na+/Ca2+ exchanger
    Ryoichi Yamaji
    Division of Applied Biological Chemistry, Graduate School of Agriculture and Biological Sciences, Osaka Prefecture University, Sakai, 5998531, Osaka, Japan
    Biochim Biophys Acta 1593:269-76. 2003
    ..However, the GAPDH activity did not rise in proportion to the increase of GAPDH protein by hypoxia even in the cytosolic fraction. These results suggest that not all hypoxia-induced GAPDH molecules contribute to glycolysis...
  28. ncbi request reprint An inhibitory role of nitric oxide in the dynamic regulation of the blood-brain barrier function
    Atsushi Yamauchi
    Department of Pharmaceutical Care and Health Sciences, Faculty of Pharmaceutical Sciences, Fukuoka University, 8 19 1 Nanakuma, Jonan ku, Fukuoka 814 0180, Japan
    Cell Mol Neurobiol 27:263-70. 2007
    ....
  29. ncbi request reprint Contribution of P-glycoprotein to efflux of ramosetron, a 5-HT3 receptor antagonist, across the blood-brain barrier
    Chika Yamamoto
    Department of Medico Pharmaceutical Sciences, Graduate School of Pharmaceutical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    J Pharm Pharmacol 54:1055-63. 2002
    ..We conclude that the limited distribution of ramosetron to the brain is due, at least in part, to efflux mediated by the P-glycoprotein at the blood-brain barrier...
  30. ncbi request reprint Hypoxic up-regulation of triosephosphate isomerase expression in mouse brain capillary endothelial cells
    Ryoichi Yamaji
    Division of Applied Biological Chemistry, Graduate School of Agriculture and Biological Sciences, Osaka Prefecture University, Sakai, Osaka 5998531, Japan
    Arch Biochem Biophys 423:332-42. 2004
    ....
  31. ncbi request reprint Uptake and efflux of quinacrine, a candidate for the treatment of prion diseases, at the blood-brain barrier
    Shinya Dohgu
    Department of Medico Pharmaceutical Sciences, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan
    Cell Mol Neurobiol 24:205-17. 2004
    ..4. These findings suggest that quinacrine transport at the BBB is mediated by the efflux system (P-gp) and the influx system (organic cation transporter-like machinery)...
  32. ncbi request reprint Transforming growth factor-beta1 upregulates the tight junction and P-glycoprotein of brain microvascular endothelial cells
    Shinya Dohgu
    Department of Medico Pharmaceutical Sciences, Graduate School of Pharmaceutical Sciences, Kyushu University, Higashi ku, Fukuoka, Japan
    Cell Mol Neurobiol 24:491-7. 2004
    ..3. The present study demonstrates that TGF-beta lowers the endothelial permeability and enhances the functional activity of P-gp, suggesting that cellular constituents producing TGF-beta in the brain may keep the BBB functioning...
  33. ncbi request reprint Transport of somatostatin and substance P by human P-glycoprotein
    Noriko Uchiyama-Kokubu
    Novartis Pharma K K, Tsukuba Research Institute, Okubo 8, Tsukuba, Ibaraki 300 2611, Japan
    FEBS Lett 574:55-61. 2004
    ..These findings suggested that certain bioactive peptides such as somatostatin and substance P directly interact with human P-glycoprotein as endogenous substrates for P-glycoprotein-mediated transport...
  34. ncbi request reprint Tolbutamide uptake via pH- and membrane-potential-dependent transport mechanism in mouse brain capillary endothelial cell line
    Noriko Koyabu
    Department of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan
    Drug Metab Pharmacokinet 19:270-9. 2004
    ..The purpose of this study was to investigate the transport mechanism of tolbutamide across the blood-brain barrier (BBB) using MBEC4 cells as an in vitro BBB model...
  35. ncbi request reprint Nitric oxide mediates cyclosporine-induced impairment of the blood-brain barrier in cocultures of mouse brain endothelial cells and rat astrocytes
    Shinya Dohgu
    Department of Pharmaceutical Care and Health Sciences, Faculty of Pharmaceutical Sciences, Fukuoka University, 8 19 1 Nanakuma, Jonan ku, Fukuoka 814 0180, Japan
    Eur J Pharmacol 505:51-9. 2004
    ..This event may be interpreted as triggering the occurrence of cyclosporine neurotoxicity...
  36. ncbi request reprint Functional characterization of adenosine transport across the BBB in mice
    Hideyasu Murakami
    Department of Medico Pharmaceutical Sciences, Graduate School of Pharmaceutical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Int J Pharm 290:37-44. 2005
    ..Transport of adenosine across the BBB in mice may be attributable to mENT1...
  37. ncbi request reprint Brain pericytes contribute to the induction and up-regulation of blood-brain barrier functions through transforming growth factor-beta production
    Shinya Dohgu
    Department of Pharmaceutical Care and Health Sciences, Faculty of Pharmaceutical Sciences, Fukuoka University, 8 19 1 Nanakuma, Jonan ku, Fukuoka 814 0180, Japan
    Brain Res 1038:208-15. 2005
    ..These findings suggest that brain pericytes contribute to the up-regulation of BBB functions through continuous TGF-beta production...
  38. ncbi request reprint Early processing of Bid and caspase-6, -8, -10, -14 in the canine brain during cardiac arrest and resuscitation
    Maryla Krajewska
    The Burnham Institute, La Jolla, CA 92037, USA
    Exp Neurol 189:261-79. 2004
    ....
  39. ncbi request reprint Inhibition of transforming growth factor-beta production in brain pericytes contributes to cyclosporin A-induced dysfunction of the blood-brain barrier
    Fuyuko Takata
    Department of Pharmaceutical Care and Health Sciences, Faculty of Pharmaceutical Sciences, Fukuoka University, Jonan ku, Fukuoka 814 0180, Japan
    Cell Mol Neurobiol 27:317-28. 2007
    ..4. These findings suggest that an inhibition of brain pericyte-derived TGF-beta1 contributes to the occurrence of CsA-induced dysfunction of the BBB...
  40. ncbi request reprint Chelating compound, chrysoidine, is more effective in both antiprion activity and brain endothelial permeability than quinacrine
    Katsumi Doh-ura
    Department of Prion Research, Tohoku University Graduate School of Medicine, 2 1 Seiryo cho, Aoba ku, Sendai 980 8575, Japan
    Cell Mol Neurobiol 27:303-16. 2007
    ..4. These chemicals might be useful as compounds for development of therapeutics for prion diseases...
  41. ncbi request reprint Inhibition of P-glycoprotein by flavonoid derivatives in adriamycin-resistant human myelogenous leukemia (K562/ADM) cells
    Tomomi Ikegawa
    Department of Medico Pharmaceutical Sciences, Graduate School of Pharmaceutical Sciences, Kyushu University, Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Cancer Lett 177:89-93. 2002
    ..Taking into consideration that these flavonoid derivatives possess antitumor promoter activity, they may become candidates of effective multidrug resistance-reversing agents in cancer chemotherapy...