Shinya Maekawa

Summary

Affiliation: University of Yamanashi
Country: Japan

Publications

  1. doi request reprint Comprehensive analysis for viral elements and interleukin-28B polymorphisms in response to pegylated interferon plus ribavirin therapy in hepatitis C virus 1B infection
    Shinya Maekawa
    Department of Advanced Medicine for Liver Diseases, University of Yamanashi, Yamanashi, Japan
    Hepatology 56:1611-21. 2012
  2. doi request reprint Viral factors influencing the response to the combination therapy of peginterferon plus ribavirin in chronic hepatitis C
    Shinya Maekawa
    First Department of Internal Medicine, University of Yamanashi, 1110 Shimokato, Chuo, Yamanashi 409 3898, Japan
    J Gastroenterol 44:1009-15. 2009
  3. pmc Analysis of the complete open reading frame of genotype 2b hepatitis C virus in association with the response to peginterferon and ribavirin therapy
    Makoto Kadokura
    First Department of Internal Medicine, Faculty of Medicine, University of Yamanashi, Chuo, Yamanashi, Japan
    PLoS ONE 6:e24514. 2011
  4. pmc Inhibition of both protease and helicase activities of hepatitis C virus NS3 by an ethyl acetate extract of marine sponge Amphimedon sp
    Yuusuke Fujimoto
    Department of Microbiology, Division of Medicine, Graduate School of Medicine and Engineering, University of Yamanashi, Yamanashi, Japan
    PLoS ONE 7:e48685. 2012
  5. pmc Deep-sequencing analysis of the association between the quasispecies nature of the hepatitis C virus core region and disease progression
    Mika Miura
    First Department of Internal Medicine, Faculty of Medicine, University of Yamanashi, Shimokato, Chuo, Yamanashi, Japan
    J Virol 87:12541-51. 2013
  6. doi request reprint Correlation between pretreatment viral sequences and the emergence of lamivudine resistance in hepatitis B virus infection
    Ryota Sueki
    First Department of Internal Medicine, Faculty of Medicine, University of Yamanashi, Chuo, Yamanashi, Japan
    J Med Virol 84:1360-8. 2012
  7. ncbi request reprint Analysis of the complete open reading frame of hepatitis C virus in genotype 2a infection reveals critical sites influencing the response to peginterferon and ribavirin therapy
    Makoto Kadokura
    First Department of Internal Medicine, Faculty of Medicine, University of Yamanashi, 1110, Shimokato, Chuo, Yamanashi, 409 3898, Japan
    Hepatol Int 5:789-99. 2011
  8. pmc Hepatitis B virus efficiently infects non-adherent hepatoma cells via human sodium taurocholate cotransporting polypeptide
    Kaori Okuyama-Dobashi
    Department of Microbiology, Faculty of Medicine, University of Yamanashi, Japan
    Sci Rep 5:17047. 2015
  9. pmc Semiannual Imaging Surveillance Is Associated with Better Survival in Patients with Non-B, Non-C Hepatocellular Carcinoma
    Kuniaki Shindo
    First Department of Internal Medicine, Faculty of Medicine, University of Yamanashi, 1110 Shimokato, Chuo, Yamanashi 409 3898, Japan
    Mediators Inflamm 2015:687484. 2015
  10. pmc Stratifying the risk of lymph node metastasis in undifferentiated-type early gastric cancer
    Yukiko Asakawa
    Yukiko Asakawa, Masahiko Ohtaka, Shinya Maekawa, Mitsuharu Fukasawa, Yasuhiro Nakayama, Tatsuya Yamaguchi, Taisuke Inoue, Tomoyoshi Uetake, Minoru Sakamoto, Tadashi Sato, Nobuyuki Enomoto, First Department of Internal Medicine, Faculty of Medicine, University of Yamanashi, Yamanashi 409 3898, Japan
    World J Gastroenterol 21:2683-92. 2015

Collaborators

Detail Information

Publications22

  1. doi request reprint Comprehensive analysis for viral elements and interleukin-28B polymorphisms in response to pegylated interferon plus ribavirin therapy in hepatitis C virus 1B infection
    Shinya Maekawa
    Department of Advanced Medicine for Liver Diseases, University of Yamanashi, Yamanashi, Japan
    Hepatology 56:1611-21. 2012
    ..2339-2379). In a multivariate analysis, the IL28B SNP (odds ratio [OR] = 16.8; P = 0.009) and NS5A aa.2340-2382 (OR = 13.8; P = 0.0003) were extracted as the two most-significant independent variables contributing to the final outcome...
  2. doi request reprint Viral factors influencing the response to the combination therapy of peginterferon plus ribavirin in chronic hepatitis C
    Shinya Maekawa
    First Department of Internal Medicine, University of Yamanashi, 1110 Shimokato, Chuo, Yamanashi 409 3898, Japan
    J Gastroenterol 44:1009-15. 2009
    ..In this review, the contribution of viral genetic variability affecting the treatment outcome is discussed according to each HCV genomic region...
  3. pmc Analysis of the complete open reading frame of genotype 2b hepatitis C virus in association with the response to peginterferon and ribavirin therapy
    Makoto Kadokura
    First Department of Internal Medicine, Faculty of Medicine, University of Yamanashi, Chuo, Yamanashi, Japan
    PLoS ONE 6:e24514. 2011
    ..However, a proportion of patients show poorer responses and the correlation between viral sequence variation and treatment outcome remains unclear...
  4. pmc Inhibition of both protease and helicase activities of hepatitis C virus NS3 by an ethyl acetate extract of marine sponge Amphimedon sp
    Yuusuke Fujimoto
    Department of Microbiology, Division of Medicine, Graduate School of Medicine and Engineering, University of Yamanashi, Yamanashi, Japan
    PLoS ONE 7:e48685. 2012
    ..Treatment with the extract of Amphimedon sp. inhibited RNA-binding ability but not ATPase activity. These results suggest that the novel compound(s) included in Amphimedon sp. can target the protease and helicase activities of HCV NS3...
  5. pmc Deep-sequencing analysis of the association between the quasispecies nature of the hepatitis C virus core region and disease progression
    Mika Miura
    First Department of Internal Medicine, Faculty of Medicine, University of Yamanashi, Shimokato, Chuo, Yamanashi, Japan
    J Virol 87:12541-51. 2013
    ....
  6. doi request reprint Correlation between pretreatment viral sequences and the emergence of lamivudine resistance in hepatitis B virus infection
    Ryota Sueki
    First Department of Internal Medicine, Faculty of Medicine, University of Yamanashi, Chuo, Yamanashi, Japan
    J Med Virol 84:1360-8. 2012
    ..046), judged by a log-rank test. Viral sequence analyses revealed the presence of amino acid substitutions in HBV pre-S1 and pre-S2 that may be associated with the emergence of lamivudine resistance during chronic HBV infection...
  7. ncbi request reprint Analysis of the complete open reading frame of hepatitis C virus in genotype 2a infection reveals critical sites influencing the response to peginterferon and ribavirin therapy
    Makoto Kadokura
    First Department of Internal Medicine, Faculty of Medicine, University of Yamanashi, 1110, Shimokato, Chuo, Yamanashi, 409 3898, Japan
    Hepatol Int 5:789-99. 2011
    ..The present study aimed to clarify the possible correlation between viral sequence variations and final outcome...
  8. pmc Hepatitis B virus efficiently infects non-adherent hepatoma cells via human sodium taurocholate cotransporting polypeptide
    Kaori Okuyama-Dobashi
    Department of Microbiology, Faculty of Medicine, University of Yamanashi, Japan
    Sci Rep 5:17047. 2015
    ..2 nM. In conclusion, non-adherent host cell conditions of infection augmented HBV infectivity in an NTCP-dependent manner, thus providing a novel strategy to identify anti-HBV drugs and investigate the mechanism of HBV infection. ..
  9. pmc Semiannual Imaging Surveillance Is Associated with Better Survival in Patients with Non-B, Non-C Hepatocellular Carcinoma
    Kuniaki Shindo
    First Department of Internal Medicine, Faculty of Medicine, University of Yamanashi, 1110 Shimokato, Chuo, Yamanashi 409 3898, Japan
    Mediators Inflamm 2015:687484. 2015
    ....
  10. pmc Stratifying the risk of lymph node metastasis in undifferentiated-type early gastric cancer
    Yukiko Asakawa
    Yukiko Asakawa, Masahiko Ohtaka, Shinya Maekawa, Mitsuharu Fukasawa, Yasuhiro Nakayama, Tatsuya Yamaguchi, Taisuke Inoue, Tomoyoshi Uetake, Minoru Sakamoto, Tadashi Sato, Nobuyuki Enomoto, First Department of Internal Medicine, Faculty of Medicine, University of Yamanashi, Yamanashi 409 3898, Japan
    World J Gastroenterol 21:2683-92. 2015
    ..To study how lymph node metastasis (LNM) risk is stratified in undifferentiated-type early gastric cancer (undiff-EGC) dependent on combinations of risk factors...
  11. doi request reprint HCV genetic elements determining the early response to peginterferon and ribavirin therapy
    Nobuyuki Enomoto
    First Department of Medicine, Faculty of Medicine, University of Yamanashi, Chuo, Yamanashi, Japan
    Intervirology 53:66-9. 2010
    ....
  12. pmc Involvement of FKBP6 in hepatitis C virus replication
    Hirotake Kasai
    Department of Microbiology, Faculty of Medicine, University of Yamanashi, Chuo shi, Yamanashi 409 3898, Japan
    Sci Rep 5:16699. 2015
    ..HCV infection promoted the expression of FKBP6, but not that of FKBP8, in cultured cells and human liver tissue. These results indicate that FKBP6 is an HCV-induced host factor that supports viral replication in cooperation with NS5A. ..
  13. pmc Deep sequencing and phylogenetic analysis of variants resistant to interferon-based protease inhibitor therapy in chronic hepatitis induced by genotype 1b hepatitis C virus
    Mitsuaki Sato
    First Department of Internal Medicine, Faculty of Medicine, University of Yamanashi, Shimokato, Chuo, Yamanashi, Japan
    J Virol 89:6105-16. 2015
    ..In conclusion, results of the study have important implications for treatment response and outcome in interferon-based protease inhibitor therapy...
  14. pmc Deep sequencing of cancer-related genes revealed GNAS mutations to be associated with intraductal papillary mucinous neoplasms and its main pancreatic duct dilation
    Shinichi Takano
    First Department of Internal Medicine, Faculty of Medicine, University of Yamanashi, Chuo, Yamanashi, Japan
    PLoS ONE 9:e98718. 2014
    ....
  15. pmc Identification of Antiviral Agents Targeting Hepatitis B Virus Promoter from Extracts of Indonesian Marine Organisms by a Novel Cell-Based Screening Assay
    Atsuya Yamashita
    Department of Microbiology, Division of Medical Sciences, Graduate School of Interdisciplinary Research, University of Yamanashi, 1110 Shimokato, Chuo, Yamanashi 409 3898, Japan
    Mar Drugs 13:6759-73. 2015
    ..These results suggest that our cell-based HBV core promoter assay system is useful to determine anti-HBV compounds, and that two PBDE compounds are expected to be candidates of lead compounds for the development of anti-HBV drugs. ..
  16. doi request reprint DICKKOPF-4 and -2 genes are upregulated in human colorectal cancer
    Akira Matsui
    First Department of Internal Medicine, Faculty of Medicine, University of Yamanashi, 1110 Shimokato, Chuo, Yamanashi, Japan
    Cancer Sci 100:1923-30. 2009
    ..We conclude that Dickkopf-4 and -2 are significantly upregulated in most colorectal tumors, and that Dickkopf-4 upregulation reflects activation of the Wnt/canonical pathway...
  17. pmc Hallmarks of hepatitis C virus in equine hepacivirus
    Tomohisa Tanaka
    Department of Microbiology, Faculty of Medicine, University of Yamanashi, Yamanashi, Japan
    J Virol 88:13352-66. 2014
    ..These results suggest that EHcV may conserve the genetic and biological properties of HCV...
  18. pmc Inhibition of hepatitis C virus replication and viral helicase by ethyl acetate extract of the marine feather star Alloeocomatella polycladia
    Atsuya Yamashita
    Department of Microbiology, Division of Medicine, Graduate School of Medicine and Engineering, University of Yamanashi, 1110 Shimokato, Chuo shi, Yamanashi 409 3898, Japan
    Mar Drugs 10:744-61. 2012
    ..polycladia can inhibit HCV replication by suppressing the helicase activity of HCV NS3. This study may present a new approach toward the development of a novel therapy for chronic hepatitis C...
  19. pmc Inhibitory effects of caffeic acid phenethyl ester derivatives on replication of hepatitis C virus
    Hui Shen
    Department of Microbiology, Division of Medicine, Graduate School of Medicine and Engineering, University of Yamanashi, Yamanashi, Japan
    PLoS ONE 8:e82299. 2013
    ..These results suggest that caffeic acid n-octyl ester is a potential candidate for novel anti-HCV chemotherapy drugs. ..
  20. doi request reprint T cell receptor-mediated signaling induces GRP78 expression in T cells: the implications in maintaining T cell viability
    Shinichi Takano
    Department of Immunology, Faculty of Medicine, University of Yamanashi, 1110 Shimokato, Chuo, Yamanashi 409 3898, Japan
    Biochem Biophys Res Commun 371:762-6. 2008
    ..These results suggest a novel regulatory mechanism and an essential function of GRP78 in T cells...
  21. doi request reprint Targeting lipid metabolism in the treatment of hepatitis C virus infection
    Fumitake Amemiya
    First Department of Internal Medicine, Faculty of Medicine, University of Yamanashi, Yamanashi, Chuo, Japan
    J Infect Dis 197:361-70. 2008
    ....
  22. ncbi request reprint Griseofulvin, an oral antifungal agent, suppresses hepatitis C virus replication in vitro
    Haofan Jin
    Department of Microbiology, University of Yamanashi, Yamanashi, Japan
    Hepatol Res 38:909-18. 2008
    ..Conclusion: Our results suggest that griseofulvin may represent a new approach to the development of a novel therapy for HCV infection...