Hideki Kimura

Summary

Affiliation: University of Fukui
Country: Japan

Publications

  1. doi request reprint Telmisartan, a possible PPAR-δ agonist, reduces TNF-α-stimulated VEGF-C production by inhibiting the p38MAPK/HSP27 pathway in human proximal renal tubular cells
    Hideki Kimura
    Division of Nephrology, Department of General Medicine, School of Medicine, Faculty of Medical Sciences, University of Fukui, Fukui, Japan Department of Clinical Laboratories and Nephrology, University of Fukui Hospital, Fukui, Japan Electronic address
    Biochem Biophys Res Commun 454:320-7. 2014
  2. doi request reprint Glucocorticoid enhances hypoxia- and/or transforming growth factor-β-induced plasminogen activator inhibitor-1 production in human proximal renal tubular cells
    Hideki Kimura
    Division of Nephrology, Department of General Medicine, School of Medicine, Faculty of Medical Sciences, University of Fukui, 23 Matsuoka Shimoaizuki, Eiheiji cho, Yoshida, Fukui 910 1193, Japan
    Clin Exp Nephrol 15:34-40. 2011
  3. doi request reprint A natural PPAR-gamma agonist, 15-deoxy-delta 12,14-prostaglandin J2, may act as an enhancer of PAI-1 in human proximal renal tubular cells under hypoxic and inflammatory conditions
    Hideki Kimura
    Division of Nephrology, Department of General Medicine, School of Medicine, Faculty of Medical Sciences, University of Fukui, Yoshida, Fukui 910 1193, Japan
    Nephrol Dial Transplant 23:2496-503. 2008
  4. doi request reprint Smaller low-density lipoprotein size as a possible risk factor for the prevalence of coronary artery diseases in haemodialysis patients: associations of cholesteryl ester transfer protein and the hepatic lipase gene polymorphism with low-density lipoprote
    Hideki Kimura
    Division of Nephrology, Department of General Medicine, School of Medicine, University of Fukui, Fukui, Japan
    Nephrology (Carlton) 16:558-66. 2011
  5. doi request reprint Dexamethasone enhances basal and TNF-alpha-stimulated production of PAI-1 via the glucocorticoid receptor regardless of 11beta-hydroxysteroid dehydrogenase 2 status in human proximal renal tubular cells
    Hideki Kimura
    Division of Nephrology, Department of General Medicine, School of Medicine, Faculty of Medical Sciences, University of Fukui, Fukui, Japan
    Nephrol Dial Transplant 24:1759-65. 2009
  6. ncbi request reprint Hypoxia reduces the expression and anti-inflammatory effects of peroxisome proliferator-activated receptor-gamma in human proximal renal tubular cells
    Xuan Li
    Division of Nephrology, Department of General Medicine, School of Medicine, Faculty of Medical Sciences, University of Fukui, 23 Matsuokashimoaizuki, Eiheiji cho, Yoshida, Fukui 910 1193, Japan
    Nephrol Dial Transplant 22:1041-51. 2007
  7. doi request reprint Lysophospholipids induce the nucleation and extension of beta2-microglobulin-related amyloid fibrils at a neutral pH
    Tadakazu Ookoshi
    Department of Pathological Sciences, Division of Molecular Pathology, Faculty of Medical Sciences, University of Fukui, Fukui 910 1193, Japan
    Nephrol Dial Transplant 23:3247-55. 2008
  8. ncbi request reprint Synergistic effect of hypoxia and TNF-alpha on production of PAI-1 in human proximal renal tubular cells
    Xuan Li
    Division of Nephrology, Department of General Medicine, School of Medicine, Faculty of Medical Sciences, Fukui University, Fukui, Japan
    Kidney Int 68:569-83. 2005
  9. ncbi request reprint Hepatic lipase mutation may reduce vascular disease prevalence in hemodialysis patients with high CETP levels
    Hideki Kimura
    Department of Clinical Laboratory Medicine and Nephrology, Faculty of Medicine, Fukui Medical University, Fukui, Japan
    Kidney Int 64:1829-37. 2003
  10. ncbi request reprint Hypoxia reduces constitutive and TNF-alpha-induced expression of monocyte chemoattractant protein-1 in human proximal renal tubular cells
    Xuan Li
    Division of Nephrology, Department of General Medicine, School of Medicine, Faculty of Medical Sciences, University of Fukui, Fukui, Japan
    Biochem Biophys Res Commun 335:1026-34. 2005

Collaborators

Detail Information

Publications24

  1. doi request reprint Telmisartan, a possible PPAR-δ agonist, reduces TNF-α-stimulated VEGF-C production by inhibiting the p38MAPK/HSP27 pathway in human proximal renal tubular cells
    Hideki Kimura
    Division of Nephrology, Department of General Medicine, School of Medicine, Faculty of Medical Sciences, University of Fukui, Fukui, Japan Department of Clinical Laboratories and Nephrology, University of Fukui Hospital, Fukui, Japan Electronic address
    Biochem Biophys Res Commun 454:320-7. 2014
    ..These results provide a novel insight into inflammation-associated lymphangiogenesis. ..
  2. doi request reprint Glucocorticoid enhances hypoxia- and/or transforming growth factor-β-induced plasminogen activator inhibitor-1 production in human proximal renal tubular cells
    Hideki Kimura
    Division of Nephrology, Department of General Medicine, School of Medicine, Faculty of Medical Sciences, University of Fukui, 23 Matsuoka Shimoaizuki, Eiheiji cho, Yoshida, Fukui 910 1193, Japan
    Clin Exp Nephrol 15:34-40. 2011
    ..Most recently, we reported that GC increases PAI-1 production in human proximal tubular epithelial cells (HPTEC). However, the detailed interactions that occur between these PAI-1 inducers in HPTEC remain to be clarified...
  3. doi request reprint A natural PPAR-gamma agonist, 15-deoxy-delta 12,14-prostaglandin J2, may act as an enhancer of PAI-1 in human proximal renal tubular cells under hypoxic and inflammatory conditions
    Hideki Kimura
    Division of Nephrology, Department of General Medicine, School of Medicine, Faculty of Medical Sciences, University of Fukui, Yoshida, Fukui 910 1193, Japan
    Nephrol Dial Transplant 23:2496-503. 2008
    ..However, no information is known about the effects of PPAR-gamma agonists on PAI-1 expression in human proximal renal tubular cells (HPTECs) under hypoxia and/or inflammation...
  4. doi request reprint Smaller low-density lipoprotein size as a possible risk factor for the prevalence of coronary artery diseases in haemodialysis patients: associations of cholesteryl ester transfer protein and the hepatic lipase gene polymorphism with low-density lipoprote
    Hideki Kimura
    Division of Nephrology, Department of General Medicine, School of Medicine, University of Fukui, Fukui, Japan
    Nephrology (Carlton) 16:558-66. 2011
    ..However, little is known about LDL size status and its relationship with CAD prevalence in haemodialysis (HD) patients who are at high risk for atherosclerosis...
  5. doi request reprint Dexamethasone enhances basal and TNF-alpha-stimulated production of PAI-1 via the glucocorticoid receptor regardless of 11beta-hydroxysteroid dehydrogenase 2 status in human proximal renal tubular cells
    Hideki Kimura
    Division of Nephrology, Department of General Medicine, School of Medicine, Faculty of Medical Sciences, University of Fukui, Fukui, Japan
    Nephrol Dial Transplant 24:1759-65. 2009
    ..However, the individual and collective effects of adrenal steroids, TNF-alpha and HSD2 status on PAI-1 production are unknown in human proximal renal tubular epithelial cells (HPTECs)...
  6. ncbi request reprint Hypoxia reduces the expression and anti-inflammatory effects of peroxisome proliferator-activated receptor-gamma in human proximal renal tubular cells
    Xuan Li
    Division of Nephrology, Department of General Medicine, School of Medicine, Faculty of Medical Sciences, University of Fukui, 23 Matsuokashimoaizuki, Eiheiji cho, Yoshida, Fukui 910 1193, Japan
    Nephrol Dial Transplant 22:1041-51. 2007
    ..However, the effects of hypoxia on the expression and anti-inflammatory actions of PPAR-gamma have yet remained to be clarified in renal tubular cells...
  7. doi request reprint Lysophospholipids induce the nucleation and extension of beta2-microglobulin-related amyloid fibrils at a neutral pH
    Tadakazu Ookoshi
    Department of Pathological Sciences, Division of Molecular Pathology, Faculty of Medical Sciences, University of Fukui, Fukui 910 1193, Japan
    Nephrol Dial Transplant 23:3247-55. 2008
    ....
  8. ncbi request reprint Synergistic effect of hypoxia and TNF-alpha on production of PAI-1 in human proximal renal tubular cells
    Xuan Li
    Division of Nephrology, Department of General Medicine, School of Medicine, Faculty of Medical Sciences, Fukui University, Fukui, Japan
    Kidney Int 68:569-83. 2005
    ..We also closely examined the effects of hypoxia and tumor necrosis factor-alpha (TNF-alpha) on PAI-1 expression in cultured human proximal renal tubular cells (HPTECs)...
  9. ncbi request reprint Hepatic lipase mutation may reduce vascular disease prevalence in hemodialysis patients with high CETP levels
    Hideki Kimura
    Department of Clinical Laboratory Medicine and Nephrology, Faculty of Medicine, Fukui Medical University, Fukui, Japan
    Kidney Int 64:1829-37. 2003
    ..However, whether the HL mutation is antiatherogenic or proatherogenic has remained unknown in uremic patients and the general population...
  10. ncbi request reprint Hypoxia reduces constitutive and TNF-alpha-induced expression of monocyte chemoattractant protein-1 in human proximal renal tubular cells
    Xuan Li
    Division of Nephrology, Department of General Medicine, School of Medicine, Faculty of Medical Sciences, University of Fukui, Fukui, Japan
    Biochem Biophys Res Commun 335:1026-34. 2005
    ..These results suggest that hypoxia is an important negative regulator of monocyte chemotaxis to the renal inflamed interstitium, by reducing MCP-1 expression partly via hypoxia-activated signals other than the HIF-1 pathway...
  11. doi request reprint Telmisartan activates endogenous peroxisome proliferator-activated receptor-δ and may have anti-fibrotic effects in human mesangial cells
    Daisuke Mikami
    Division of Nephrology, Department of Medicine, Faculty of Medical Sciences, School of Medicine, University of Fukui, Fukui, Japan
    Hypertens Res 37:422-31. 2014
    ....
  12. ncbi request reprint [Molecular structures and function of proximal tubular cells]
    Hideki Kimura
    Division of Nephrology, School of Medical Sciences, University of Fukui
    Nihon Rinsho 64:84-7. 2006
  13. doi request reprint Renal resistive index correlates with peritubular capillary loss and arteriosclerosis in biopsy tissues from patients with chronic kidney disease
    Noriyo Kimura
    Division of Nephrology, Department of General Medicine, University of Fukui, 23 3 Shimoaizuki, Matsuoka, Eiheiji cho, Yoshida gun, Fukui, 910 1193, Japan
    Clin Exp Nephrol 19:1114-9. 2015
    ..The aim of this study was to investigate the factors related to the RI elevation in chronic kidney disease (CKD)...
  14. ncbi request reprint [Clinical application of urinary redox regulating protein, thioredoxin]
    Kenji Kasuno
    Division of Nephrology and Clinical Laboratories, University of Fukui Hospital, Yoshida gun, Fukui pref 910 1193, Japan
    Rinsho Byori 59:189-95. 2011
    ..TRX is useful for the diagnosis of AKI in association with oxidative stress...
  15. pmc Rapid detection of the Mycobacterium tuberculosis complex by use of quenching probe PCR (geneCube)
    Yukio Hida
    Department of Clinical Laboratories, University of Fukui, Fukui, Japan
    J Clin Microbiol 50:3604-8. 2012
    ..5 h with the Amplicor system). The geneCube thus enables a significant shortening of the assay time with no loss of sensitivity or specificity...
  16. doi request reprint Renal redox dysregulation in AKI: application for oxidative stress marker of AKI
    Kenji Kasuno
    Division of Nephrology, Department of General Medicine, School of Medicine, University of Fukui, Fukui, Japan
    Am J Physiol Renal Physiol 307:F1342-51. 2014
    ..These findings suggest that urinary TRX1 is an oxidative stress-specific biomarker useful for distinguishing AKI from chronic kidney disease and healthy kidneys. ..
  17. ncbi request reprint [Increased expression of plasminogen activator inhibitor-1 in hypoxic renal injury and its pathological significance in progression of advanced renal disease]
    Hideki Kimura
    Division of Laboratory Medicine, School of Medicine, University of Fukui, Yoshida gun, Fukui
    Rinsho Byori 53:749-58. 2005
    ..Hypoxia together with inflammation may also be involved in promotion of renal fibrosis in part by modulating MCP-1 and VEGF expression...
  18. doi request reprint Growth of beta(2)-microglobulin-related amyloid fibrils by non-esterified fatty acids at a neutral pH
    Kazuhiro Hasegawa
    Division of Molecular Pathology, Department of Pathological Sciences, Faculty of Medical Sciences, University of Fukui, 23 3 Matsuokashimoaizuki, Eiheiji, Fukui 910 1193, Japan
    Biochem J 416:307-15. 2008
    ..These results suggest the involvement of NEFAs in the development of Abeta2M amyloidosis, and in the pathogenesis of Abeta2M amyloidosis...
  19. doi request reprint A specific serum IgA antibody discriminates pneumonia from colonization state in patients with Pseudomonas aeruginosa in sputum culture
    Masanori Yamashita
    Division of Clinical Laboratories, University of Fukui Hospital, Fukui, Japan
    J Microbiol Methods 82:198-204. 2010
    ..These findings suggest that IgA antibody ELISA, rather than IgG antibody ELISA, may be useful for differentiating P. aeruginosa-related pneumonia from latent colonization in immunocompromised patients with a positive sputum culture...
  20. ncbi request reprint Synthetic/secreting and apoptotic phenotypes in renal biopsy tissues from hypertensive nephrosclerosis patients
    Noriyo Kimura
    Division of Nephrology, University of Fukui Hospital, Fukui, Japan
    Hypertens Res 29:573-80. 2006
    ....
  21. doi request reprint Severe intraglomerular detachment of podocytes in a Gitelman syndrome patient
    Naoki Takahashi
    Division of Nephrology, Department of General Medicine, Faculty of Medical Sciences, University of Fukui, Fukui, Japan
    Clin Exp Nephrol 16:495-500. 2012
    ..This podocyte detachment may be associated with nephron obstruction and reduced nephrin expression...
  22. pmc Serum CETP status is independently associated with reduction rates in LDL-C in pitavastatin-treated diabetic patients and possible involvement of LXR in its association
    Akihiro Shimada
    Department of Clinical Laboratory and Nephrology, University of Fukui Hospital, 23 3 Matsuoka Shimoaizuki, Eiheiji, Yoshida, Fukui, 910 1193, Japan
    Lipids Health Dis 15:57. 2016
    ....
  23. doi request reprint The clinical significance of abnormal diurnal blood pressure variation in healthy late middle-aged and older adults
    Toshihiko Hamada
    Department of Clinical and Laboratory Science, University of Fukui, Fukui, Japan
    Blood Press 17:134-40. 2008
    ..Conclusion. In healthy elderly subjects, the extreme-dipper type may reflect a decrease in endothelial function, i.e. initial stage atherosclerosis, rather than the dipper type...
  24. ncbi request reprint Methylenetetrahydrofolate reductase polymorphism in childhood primary focal segmental glomerulosclerosis
    Chaochun Zou
    Department of Pediatrics, Faculty of Medicine, Fukui Medical University, Fukui 910 1193, Japan
    Nephron 92:449-51. 2002
    ..The purpose of this study was to evaluate the association between the methylenetetrahydrofolate reductase (MTHFR) C/T polymorphism and the prevalence and course of focal segmental glomerulosclerosis (FSGS) in our pediatric population...