Michio Kaminishi

Summary

Affiliation: University of Tokyo
Country: Japan

Publications

  1. ncbi request reprint Diversity of gastric carcinogenesis
    Michio Kaminishi
    Department of Gastrointestinal Surgery, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Oncology 69:1-8. 2005
  2. ncbi request reprint [Management of patients with neuroendocrine tumors of the esophagus, stomach, and duodenum]
    Nobuyuki Shimizu
    Department of Gastrointestinal Surgery, University of Tokyo Graduate School of Medicine, Tokyo, Japan
    Nihon Geka Gakkai Zasshi 109:147-51. 2008
  3. pmc Loss of HGF activator inhibits foveolar hyperplasia induced by oxyntic atrophy without altering gastrin levels
    Yukinori Yamagata
    Department of Gastrointestinal Surgery, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Am J Physiol Gastrointest Liver Physiol 303:G1254-61. 2012
  4. ncbi request reprint Nutritional comparisons between a pylorus-preserving gastrectomy with and without suprapyloric lymph node clearance: a preliminary report
    Shouji Shimoyama
    Department of Gastrointestinal Surgery, University of Tokyo, Tokyo, Japan
    Hepatogastroenterology 54:2401-5. 2007
  5. doi request reprint Columnar metaplasia in a surgical mouse model of gastro-esophageal reflux disease is not derived from bone marrow-derived cell
    Susumu Aikou
    Department of Gastrointestinal Surgery, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Cancer Sci 104:1154-61. 2013
  6. doi request reprint Multicenter phase II randomized study evaluating dose-response of antiperistaltic effect of L-menthol sprayed onto the gastric mucosa for upper gastrointestinal endoscopy
    Naoki Hiki
    Department of Gastroenterological Surgery, Gastroenterological Center, Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo, Japan
    Dig Endosc 24:79-86. 2012
  7. pmc Gastric cancer treatment in Japan: 2008 annual report of the JGCA nationwide registry
    Yoh Isobe
    Department of Surgery, National Hospital Organization Tokyo Medical Center, 2 5 1 Higashigaoka, Meguro ku, Tokyo, Japan
    Gastric Cancer 14:301-16. 2011
  8. doi request reprint Luminal and cancer cells in the breast show more rapid telomere shortening than myoepithelial cells and fibroblasts
    Rie Kurabayashi
    Division of Metabolic Care and Endocrine Surgery, Department of Surgery, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Hum Pathol 39:1647-55. 2008
  9. doi request reprint Alterations in gastric mucosal lineages before or after acute oxyntic atrophy in gastrin receptor and H2 histamine receptor-deficient mice
    Susumu Aikou
    Department of Gastrointestinal Surgery, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, 113 8655, Japan
    Dig Dis Sci 54:1625-35. 2009
  10. doi request reprint Gastric carcinogenesis by N-Methyl-N-nitrosourea is enhanced in db/db diabetic mice
    Nao Yoshizawa
    Department of Gastrointestinal Surgery, The University of Tokyo, Tokyo 113 8655, Japan
    Cancer Sci 100:1180-5. 2009

Detail Information

Publications104 found, 100 shown here

  1. ncbi request reprint Diversity of gastric carcinogenesis
    Michio Kaminishi
    Department of Gastrointestinal Surgery, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Oncology 69:1-8. 2005
    ....
  2. ncbi request reprint [Management of patients with neuroendocrine tumors of the esophagus, stomach, and duodenum]
    Nobuyuki Shimizu
    Department of Gastrointestinal Surgery, University of Tokyo Graduate School of Medicine, Tokyo, Japan
    Nihon Geka Gakkai Zasshi 109:147-51. 2008
    ..Somatostatin analogues, such as octreotide and SOM 230, have been registered for the control of hormonal symptoms in patients with gastrointestinal NETs...
  3. pmc Loss of HGF activator inhibits foveolar hyperplasia induced by oxyntic atrophy without altering gastrin levels
    Yukinori Yamagata
    Department of Gastrointestinal Surgery, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Am J Physiol Gastrointest Liver Physiol 303:G1254-61. 2012
    ..However, the absence of HGFA signaling causes a delay in the recovery from SPEM to normal glandular composition. HGFA also promotes foveolar cell hyperplasia and mucosal cell proliferation in acute oxyntic injury...
  4. ncbi request reprint Nutritional comparisons between a pylorus-preserving gastrectomy with and without suprapyloric lymph node clearance: a preliminary report
    Shouji Shimoyama
    Department of Gastrointestinal Surgery, University of Tokyo, Tokyo, Japan
    Hepatogastroenterology 54:2401-5. 2007
    ....
  5. doi request reprint Columnar metaplasia in a surgical mouse model of gastro-esophageal reflux disease is not derived from bone marrow-derived cell
    Susumu Aikou
    Department of Gastrointestinal Surgery, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Cancer Sci 104:1154-61. 2013
    ..However, bone marrow-derived cells do not contribute directly to columnar metaplasia in this mouse model...
  6. doi request reprint Multicenter phase II randomized study evaluating dose-response of antiperistaltic effect of L-menthol sprayed onto the gastric mucosa for upper gastrointestinal endoscopy
    Naoki Hiki
    Department of Gastroenterological Surgery, Gastroenterological Center, Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo, Japan
    Dig Endosc 24:79-86. 2012
    ....
  7. pmc Gastric cancer treatment in Japan: 2008 annual report of the JGCA nationwide registry
    Yoh Isobe
    Department of Surgery, National Hospital Organization Tokyo Medical Center, 2 5 1 Higashigaoka, Meguro ku, Tokyo, Japan
    Gastric Cancer 14:301-16. 2011
    ....
  8. doi request reprint Luminal and cancer cells in the breast show more rapid telomere shortening than myoepithelial cells and fibroblasts
    Rie Kurabayashi
    Division of Metabolic Care and Endocrine Surgery, Department of Surgery, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Hum Pathol 39:1647-55. 2008
    ..Tissue quantitative fluorescence in situ hybridization, applicable to analysis of individual cells in tissue sections, is considered to be a powerful technique with considerable promise for studies in oncology...
  9. doi request reprint Alterations in gastric mucosal lineages before or after acute oxyntic atrophy in gastrin receptor and H2 histamine receptor-deficient mice
    Susumu Aikou
    Department of Gastrointestinal Surgery, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, 113 8655, Japan
    Dig Dis Sci 54:1625-35. 2009
    ..The H(2) receptor and gastrin receptor do not affect emergence of SPEM. However, it is suggested that the absence of H(2) receptor signaling causes a delay in the maturation of chief cells from mucous neck cells...
  10. doi request reprint Gastric carcinogenesis by N-Methyl-N-nitrosourea is enhanced in db/db diabetic mice
    Nao Yoshizawa
    Department of Gastrointestinal Surgery, The University of Tokyo, Tokyo 113 8655, Japan
    Cancer Sci 100:1180-5. 2009
    ..The serum levels of insulin and leptin were also elevated in Group A. Gastric carcinogenesis by MNU was enhanced in db/db mice, possibly in association with hyperinsulinemia and hyperleptinemia...
  11. doi request reprint Efficacy of spraying l-menthol solution during endoscopic treatment of early gastric cancer: a phase III, multicenter, randomized, double-blind, placebo-controlled study
    Mitsuhiro Fujishiro
    Department of Endoscopy and Endoscopic Surgery, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, 113 8655, Japan
    J Gastroenterol 49:446-54. 2014
    ..However, it remains unclear whether l-menthol is similarly effective during therapeutic endoscopy, thereby improving treatment outcomes in a clinical setting...
  12. doi request reprint Physiological evaluation of residual stomach motility after local resection in conscious dogs
    Keisuke Kubota
    Department of Surgery, International University of Health and Welfare Mita Hospital, 1 4 3 Mita, Minato ku, Tokyo, 108 8329, Japan
    Surg Today 41:680-7. 2011
    ..To investigate the phenomenon of remnant gastric motility and emptying after local resection...
  13. doi request reprint Association between frequent CpG island methylation and HER2 amplification in human breast cancers
    Kotoe Terada
    Carcinogenesis Division, National Cancer Center Research Institute, Tokyo, Japan
    Carcinogenesis 30:466-71. 2009
    ..001). These showed that frequent methylation had a strong association with HER2 amplification in breast cancers and suggested that frequent methylation can be a determinant of various characteristics in a fraction of human breast cancers...
  14. pmc Tests for serum levels of trefoil factor family proteins can improve gastric cancer screening
    Susumu Aikou
    Department of Gastrointestinal Surgery, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Gastroenterology 141:837-845.e1-7. 2011
    ..We investigated whether serum levels of TFF can be used as markers for gastric cancer screening...
  15. ncbi request reprint Effect of imatinib mesylate in a patient with a metastatic gastrointestinal stromal tumor with a c-kit mutation in exon 11
    Keisuke Kubota
    Department of Surgery, The International University of Health and Welfare Mita Hospital, Mita, Tokyo, Japan
    Dig Dis Sci 52:1725-9. 2007
  16. doi request reprint Glypican 3-expressing gastric carcinoma: distinct subgroup unifying hepatoid, clear-cell, and alpha-fetoprotein-producing gastric carcinomas
    Tetsuo Ushiku
    Department of Pathology and Diagnostic Pathology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Cancer Sci 100:626-32. 2009
    ..GPC3-GC is a distinctive group of GC, which unifies hepatoid, clear-cell, and alpha-fetoprotein-producing GC. GPC3 is expected to be a target of forthcoming immunotherapy for a patient bearing this specific type of GC...
  17. ncbi request reprint Autopsy findings in patients after curative esophagectomy for esophageal carcinoma
    Atom Katayama
    Department of Gastrointestinal Surgery, The University of Tokyo Graduate School of Medicine, Japan
    J Am Coll Surg 196:866-73. 2003
    ..The mode of recurrence after esophagectomy for esophageal cancer has seldom been studied in detail from autopsy findings...
  18. ncbi request reprint Helicobacter pylori-negative / API2-MALT1 translocation-negative low-grade MALT lymphoma
    Koji Nozaki
    Department of Gastrointestinal Surgery, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, 113 8655, Japan
    Gastric Cancer 9:229-34. 2006
    ....
  19. ncbi request reprint Emergence of spasmolytic polypeptide-expressing metaplasia in Mongolian gerbils infected with Helicobacter pylori
    Nao Yoshizawa
    Department of Gastrointestinal Surgery, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Lab Invest 87:1265-76. 2007
    ..SPEM develops early in Hp infection in Mongolian gerbils, and alterations in gland morphology arise from SPEM glands during the course of gastric infection with goblet cell intestinal metaplasia developing subsequent to SPEM...
  20. ncbi request reprint Excision of postesophageal parathyroid adenoma in posterior mediastinum with intraoperative 99mTechnetium sestamibi scanning
    Toshihisa Ogawa
    Department of Endocrine Surgery, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Ann Thorac Surg 84:1754-6. 2007
    ..A thoracotomy was required to remove this tumor. Radioisotope-guided surgery was effective at identifying the tumor...
  21. ncbi request reprint Accuracy of linear-array EUS for preoperative staging of gastric cardia cancer
    Shouji Shimoyama
    Department of Gastrointestinal Surgery, University of Tokyo, Japan
    Gastrointest Endosc 60:50-5. 2004
    ..EUS is considered the most reliable staging modality. However, there is no EUS study specifically of cardia cancer...
  22. pmc Transverse carcinoma after Miles operation: a case in which preoperative evaluation was assisted by computed tomographic colonography
    Daisuke Ito
    Department of Gastrointestinal Surgery, Showa General Hospital, 8 1 1, Hanakoganei, Kodaira, Tokyo, 187 8510, Japan
    World J Surg Oncol 14:118. 2016
    ..There were only few case reports in which CTC was performed in patients with colostomy...
  23. pmc Amebiasis presenting as acute appendicitis: Report of a case and review of Japanese literature
    Daisuke Ito
    Department of Gastrointestinal Surgery, Showa General Hospital, Tokyo, Japan Electronic address
    Int J Surg Case Rep 5:1054-7. 2014
    ..Outside of these high-risk regions, acute amebic appendicitis is considerably rarer and the mortality rate is much higher than with non-amebic appendicitis...
  24. ncbi request reprint Preoperative evaluation of thyroid pathology in patients with primary hyperparathyroidism
    Toshihisa Ogawa
    Department of Endocrine Surgery, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Thyroid 17:59-62. 2007
    ..The prevalence of thyroid disease associated with hyperparathyroidism is high, and evaluation of the thyroid pathology by US enables the shift from bilateral neck exploration to the minimally invasive parathyroid surgery...
  25. ncbi request reprint Surgical treatment of early gastric cancer
    Sachiyo Nomura
    Department of Gastrointestinal Surgery, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Dig Surg 24:96-100. 2007
    ..Even with these improvements, the 5-year survival of early gastric cancer is more than 90% in Japan. Further improvements would be possible in the future...
  26. ncbi request reprint Telomere metabolism and diagnostic demonstration of telomere measurement in the human esophagus for distinguishing benign from malignant tissue by tissue quantitative fluorescence in situ hybridization
    Makoto Kammori
    Department of Breast, Tokyo Metropolitan Tama Cancer Detection Center, Fuchu shi, Tokyo, Japan
    Oncology 71:430-6. 2006
    ..We hypothesized that the very rapid cell proliferation observed in esophageal squamous cell carcinomas might accelerate the telomere shortening and chromosomal instability associated with carcinogenesis...
  27. ncbi request reprint Studies of 13C-urea breath test for diagnosis of Helicobacter pylori infection in patients after partial gastrectomy
    Keisuke Kubota
    Department of Gastrointestinal Surgery, University of Tokyo, Japan
    Digestion 65:82-6. 2002
    ..We conducted an evaluation to establish a standardized protocol and an appropriate cutoff value for 13C-UBT in partial gastrectomy patients...
  28. pmc Neuronal stimulation with 5-hydroxytryptamine 4 receptor induces anti-inflammatory actions via α7nACh receptors on muscularis macrophages associated with postoperative ileus
    Yasuaki Tsuchida
    Department of Veterinary Pharmacology, The University of Tokyo, Bunkyo ku, Tokyo 113 8657, Japan
    Gut 60:638-47. 2011
    ..Prokinetic 5-hydroxytryptamine 4 receptor (5-HT₄R) agonists and dopamine receptor antagonists are potential therapeutic agents for directly ameliorating the motility disorder associated with POI...
  29. ncbi request reprint Concepts, rationale, and current outcomes of less invasive surgical strategies for early gastric cancer: data from a quarter-century of experience in a single institution
    Shouji Shimoyama
    Department of Gastrointestinal Surgery, University of Tokyo, 3 7 1, Hongo, Tokyo, Bunkyo ku 113 8655, Japan
    World J Surg 29:58-65. 2005
    ..These results suggest that each of our criteria for less invasive surgery for EGC is realistic, well stratified, and satisfactory...
  30. ncbi request reprint Distribution of angiogenin and its gene message in colorectal cancer patients and their clinical relevance
    Shouji Shimoyama
    Department of Gastrointestinal Surgery, University of Tokyo, Japan
    Anticancer Res 22:1045-52. 2002
    ..corrected] The distribution of angiogenin (ANG) in normal colorectal and colorectal cancer tissues has not been precisely elucidated, while studies on the clinical significance of ANG have been scanty at best...
  31. ncbi request reprint Indications of a minimized scope of lymphadenectomy for submucosal gastric cancer
    Shouji Shimoyama
    Department of Gastrointestinal Surgery, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Ann Surg Oncol 9:625-31. 2002
    ..A recent trend for less invasive surgery has increased consideration for a minimized scope of lymphadenectomy for submucosal cancer; however, feasibility criteria have not been precisely established...
  32. ncbi request reprint Efficacy of triple therapy plus cetraxate for the Helicobacter pylori eradication in partial gastrectomy patients
    Keisuke Kubota
    Department of Gastrointestinal Surgery, The University of Tokyo, Tokyo, Japan
    Dig Dis Sci 50:842-6. 2005
    ..024) but not in LEFT (P = 0.058). Adverse events that occurred in each group were almost all mild ones. Cetraxate plus LAC for 1 week is a safe and effective regime for the eradication of H. pylori in patients after partial gastrectomy...
  33. ncbi request reprint Identification of spasmolytic polypeptide expressing metaplasia (SPEM) in remnant gastric cancer and surveillance postgastrectomy biopsies
    Hirokazu Yamaguchi
    Department of Gastrointestinal Surgery, Graduate School of Medicine, University of Tokyo, Japan
    Dig Dis Sci 47:573-8. 2002
    ..These findings implicate SPEM as a potential precursor lesion of gastric adenocarcinoma...
  34. ncbi request reprint Performance of outpatient regimen of S-1 in combination with fractional cisplatin for advanced or recurrent gastric cancers: a phase I study
    Shouji Shimoyama
    Department of Gastrointestinal Surgery, University of Tokyo, 7 3 1 Hongo, Tokyo 113 8655, Japan
    Int J Clin Oncol 10:251-5. 2005
    ....
  35. ncbi request reprint Supra-additive antitumor activity of 5FU with tumor necrosis factor-related apoptosis-inducing ligand on gastric and colon cancers in vitro
    Shouji Shimoyama
    Department of Gastrointestinal Surgery, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Int J Oncol 21:643-8. 2002
    ....
  36. ncbi request reprint An advanced strategy of enhanced specific gene expression for hepatocellular carcinoma
    Hiroto Takikawa
    Department of Surgery, Graduate School of Medicine, University of Tokyo, Tokyo 113 8655, Japan
    Int J Oncol 22:1051-6. 2003
    ..This AFP-producing cell specific gene transduction, employing our enhanced gene expression method, may contribute to targeting gene therapies with a variety of vectors...
  37. ncbi request reprint Diffuse large B-cell lymphoma in the thyroid gland associated with primary hyperparathyroidism
    Toshihisa Ogawa
    Department of Breast and Endocrine Surgery, Faculty of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Int J Clin Oncol 12:48-51. 2007
    ..To our knowledge, this is the first report to describe a malignant thyroid lymphoma associated with primary hyperparathyroidism...
  38. ncbi request reprint Angiogenin in sera as an independent prognostic factor in gastric cancer
    Shouji Shimoyama
    Department of Gastrointestinal Surgery, University of Tokyo, 7 3 1 Hongo Bunkyo ku, 113 8655, Tokyo, Japan
    J Cancer Res Clin Oncol 129:239-44. 2003
    ....
  39. ncbi request reprint Indications for a pylorus-preserving gastrectomy for gastric cancer with proper muscle invasion
    Shouji Shimoyama
    Department of Gastrointestinal Surgery, University of Tokyo, Tokyo, Japan
    Arch Surg 138:1235-9. 2003
    ....
  40. ncbi request reprint Diabetic mastopathy in an advanced elderly woman with insulin-dependent type 2 diabetes mellitus
    Tetsu Kojima
    Department of Surgery, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Breast Cancer 10:374-7. 2003
    ..Surgical excision was thus performed and diabetic mastopathy was confirmed pathologically. We report on this rare case of diabetic mastopathy in a 76 year-old type 2 diabetic patient...
  41. ncbi request reprint Utility of [13C] urea breath test for Helicobacter pylori detection in partial gastrectomy patients
    Keisuke Kubota
    Department of Gastrointestinal Surgery, The University of Tokyo, Tokyo, Japan
    Dig Dis Sci 48:2135-8. 2003
    ..In the present protocol [13C] UBT appears to be a reliable and convenient tool with the same accuracy rate as other routine tests in patients with a remnant stomach...
  42. ncbi request reprint Activity and safety of a low dose, fractional administration of irinotecan hydrochloride (CPT-11) in combination with cisplatin for relapsed gastric cancer patients: a preliminary report
    Shouji Shimoyama
    Department of Gastrointestinal Surgery, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Int J Clin Oncol 8:49-52. 2003
    ....
  43. ncbi request reprint Early gastric cancer development in a familial adenomatous polyposis patient
    Shouji Shimoyama
    Department of Gastrointestinal Surgery, University of Tokyo, 7 3 1 Hongo, Bunkyo ku Tokyo 113 8655, Japan
    Dig Dis Sci 49:260-5. 2004
  44. pmc Cecal volvulus caused by endometriosis in a young woman
    Daisuke Ito
    Department of Gastrointestinal Surgery, Showa General Hospital, 8 1 1, Hanakoganei, Kodaira, Tokyo, 187 8510, Japan
    BMC Surg 15:77. 2015
    ..Cecal volvulus is relatively rare. Moreover, to the best of our knowledge, a case of cecal volvulus caused by endometriosis has not yet been reported...
  45. doi request reprint Antiperistaltic effect and safety of L-menthol sprayed on the gastric mucosa for upper GI endoscopy: a phase III, multicenter, randomized, double-blind, placebo-controlled study
    Naoki Hiki
    Department of Gastroenterological Surgery, Gastroenterological Center, Cancer Institute Hospital, Japanese Foundation for Cancer Research, and Department of Gastrointestinal Surgery, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Gastrointest Endosc 73:932-41. 2011
    ..GI peristalsis during GI endoscopy commonly requires intravenous or intramuscular injection of antispasmodic agents, which sometimes cause unexpected adverse reactions...
  46. ncbi request reprint Inhibition of cyclooxygenase-2 suppresses lymph node metastasis via reduction of lymphangiogenesis
    Caname Iwata
    Department of Molecular Pathology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Cancer Res 67:10181-9. 2007
    ..Our findings suggest that COX-2 inhibitor may be useful for prophylaxis of lymph node metastasis by reducing macrophage-mediated tumor lymphangiogenesis...
  47. ncbi request reprint A three-year survivor case of gastric cancer with peritoneal dissemination--an outpatient with second-line weekly paclitaxel
    Shouji Shimoyama
    Gastrointestinal Unit, Settlement Clinic, Adachi ku, Tokyo, Japan
    Gan To Kagaku Ryoho 35:1003-7. 2008
    ....
  48. doi request reprint The presence of aberrant DNA methylation in noncancerous esophageal mucosae in association with smoking history: a target for risk diagnosis and prevention of esophageal cancers
    Daiji Oka
    Carcinogenesis Division, National Cancer Center Research Institute, Tokyo, Japan
    Cancer 115:3412-26. 2009
    ..In this study, the objective was to elucidate the effects of smoking and drinking on the accumulation of epigenetic alterations in background mucosae...
  49. ncbi request reprint Efficacy of peppermint oil as an antispasmodic during endoscopic retrograde cholangiopancreatography
    Natsuyo Yamamoto
    Department of Gastroenterology, University of Tokyo, Tokyo, Japan
    J Gastroenterol Hepatol 21:1394-8. 2006
    ..The purpose of the present paper was therefore to investigate peppermint as an antispasmodic for ERCP...
  50. doi request reprint An open-label, single-arm study assessing the efficacy and safety of L: -menthol sprayed onto the gastric mucosa during upper gastrointestinal endoscopy
    Naoki Hiki
    Department of Gastroenterological Surgery, Gastroenterological Center, Cancer Institute Hospital, Japanese Foundation for Cancer Research, 3 10 6 Ariake, Koto ku, Tokyo, 135 8550, Japan
    J Gastroenterol 46:873-82. 2011
    ..The aim of the study reported here was to determine whether the anti-peristaltic effect of an L: -menthol preparation facilitates endoscopic examinations in a clinical setting...
  51. ncbi request reprint Demonstration of human telomerase reverse transcriptase in human colorectal carcinomas by in situ hybridization
    Makoto Kammori
    Department of Gastrointestinal Surgery, The University of Tokyo, Tokyo 113 0033, Japan
    Int J Oncol 20:15-21. 2002
    ..Our findings suggest that ISH-based analysis of hTERT gene expression is superior to both TRAP telomerase activity and hTERT mRNA RT-PCR analysis as a means of determining telomerase status during carcinogenesis...
  52. ncbi request reprint Quantitative detection of micrometastases in the lymph nodes of gastric cancer patients with real-time RT-PCR: a comparative study with immunohistochemistry
    Keisuke Kubota
    Department of Gastrointestinal Surgery, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    Int J Cancer 105:136-43. 2003
    ..These results indicate that duplex quantitative real-time RT-PCR is the most sensitive method for detecting micrometastases and useful for evaluating the prognostic significance of lymph node micrometastasis in gastric cancer patients...
  53. pmc Clinical and computed tomography findings of appendiceal diverticulitis vs acute appendicitis
    Daisuke Ito
    Daisuke Ito, Kenji Miki, Shojiro Hata, Kaoru Kobayashi, Masanori Teruya, Michio Kaminishi, Department of Gastrointestinal Surgery, Showa General Hospital, Tokyo 187 8510, Japan
    World J Gastroenterol 21:3921-7. 2015
    ..To study the clinical features and computed tomography (CT) findings of appendiceal diverticulitis vs acute appendicitis...
  54. ncbi request reprint Laparoscopy-assisted pylorus-preserving gastrectomy with quality controlled lymph node dissection in gastric cancer operation
    Naoki Hiki
    Gastroenterological Center, Department of Gastroenterological Surgery, Cancer Institute, Ariake Hospital, Japanese Foundation for Cancer Research, Tokyo, Japan
    J Am Coll Surg 203:162-9. 2006
    ..Pylorus-preserving gastrectomy (PPG) with extensive lymph node dissection is useful for treatment of early gastric cancer with preservation of function. This technique could be improved by using laparoscopy-assisted gastrectomy...
  55. ncbi request reprint Detection of minimal gastric cancer cells in peritoneal washings by focused microarray analysis with multiple markers: clinical implications
    Kazuhiko Mori
    Department of Gastrointestinal Surgery, University of Tokyo Graduate School of Medicine, Hongo 7 3 1, Bunkyo ku, Tokyo, 113 8655, Japan
    Ann Surg Oncol 14:1694-702. 2007
    ..A reverse transcriptase-polymerase chain reaction-based assay with multiple marker genes or immunocytochemistry was assessed as an alternative method of gathering the same kind of data as cytology...
  56. doi request reprint BRCA2 interacts with the cytoskeletal linker protein plectin to form a complex controlling centrosome localization
    Takayoshi Niwa
    Department of Endocrine Surgery and Gastrointestinal Surgery, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Cancer Sci 100:2115-25. 2009
    ..We suggest that the BRCA2-plectin interaction plays an important role in the regulation of centrosome localization and also that displacement of the centrosome may result in genomic instability and cancer development...
  57. ncbi request reprint Image in endocrinology: giant mediastinal cystic parathyroid adenoma
    Makoto Kammori
    Division of Metabolic Care Unit and Endocrine Surgery, Department of Cardiothoracic Surgery, Graduate School of Medicine, The University of Tokyo, Tokyo 113 8655, Japan
    J Clin Endocrinol Metab 91:1635-6. 2006
  58. ncbi request reprint Lysyl oxidase is a tumor suppressor gene inactivated by methylation and loss of heterozygosity in human gastric cancers
    Atsushi Kaneda
    Carcinogenesis Division, National Cancer Center Research Institute, Tokyo, Japan
    Cancer Res 64:6410-5. 2004
    ..These data showed that LOX is a tumor suppressor gene inactivated by methylation and loss of heterozygosity in gastric cancers, and possibly also in other cancers...
  59. ncbi request reprint Pylorus-preserving gastrectomy in gastric cancer surgery--open and laparoscopic approaches
    Naoki Hiki
    Department of Gastrointestinal Surgery, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Langenbecks Arch Surg 390:442-7. 2005
    ..The aim of this article is to describe procedures for PPG. The technique of laparoscopy-assisted pylorus-preserving gastrectomy (LAPPG) is also introduced because PPG is an ideal application for laparoscopic surgery...
  60. ncbi request reprint Safety of a paraaortic node dissection for selected advanced gastric cancer patients
    Shouji Shimoyama
    Department of Gastrointestinal Surgery, University of Tokyo, Tokyo, Japan
    Hepatogastroenterology 52:1631-5. 2005
    ..Comprehensive evaluations of a superextended (D3) dissection concerning its benefits as well as potential disadvantages have been scanty in the English literature...
  61. ncbi request reprint Simultaneous onset of acute inflammatory response, sepsis-like symptoms and intestinal mucosal injury after cancer chemotherapy
    Eiichi Tsuji
    Department of Surgery, University of Tokyo, Tokyo, Japan
    Int J Cancer 107:303-8. 2003
    ..These results suggest that bacterial/endotoxin translocation might cause sepsis-like manifestations after systemic chemotherapy...
  62. doi request reprint Guidelines for sedation in gastroenterological endoscopy
    Katsutoshi Obara
    The Japan Gastroenterological Endoscopy Society, Tokyo, Japan
    Dig Endosc 27:435-49. 2015
    ..In clinical practice, the final decision as to the use of sedation should be made by physicians considering patient willingness and physical condition. ..
  63. pmc Index of convexity: a novel liver function index using Tc-GSA scintigraphy
    Kenji Miki
    Department of Gastrointestinal Surgery, Showa General Hospital, Tokyo187 8510, Japan
    World J Gastroenterol 19:92-6. 2013
    ....
  64. ncbi request reprint The intergroup/RTOG 85-01 concurrent chemoradiation regimen for Japanese esophageal cancer
    Hideomi Yamashita
    Department of Radiology, University of Tokyo Hospital, Tokyo, Japan
    Hepatogastroenterology 53:863-8. 2006
    ..To evaluate outcome of the U.S. RTOG/Intergroup Protocol 85-01 for 44 Japanese esophageal cancer patients...
  65. ncbi request reprint Gastric cancer treated in 1991 in Japan: data analysis of nationwide registry
    Keiichi Maruyama
    Data Center of the Japanese Gastric Cancer Association, c o Department of Surgical Oncology, National Cancer Center Hospital, Tokyo, Japan
    Gastric Cancer 9:51-66. 2006
    ....
  66. ncbi request reprint Oral peppermint oil is a useful antispasmodic for double-contrast barium meal examination
    Shigeaki Mizuno
    Department of Gastroenterology and Hepatology, Nihon University School of Medicine, Tokyo, Japan
    J Gastroenterol Hepatol 21:1297-301. 2006
    ..The aim of this study was to examine the efficacy of oral PO for double-contrast barium meal examination (DCBM) without other antispasmodics...
  67. ncbi request reprint [Eradication therapy for the remnant stomach infected with Helicobacter pylori ]
    Nobuyuki Shimizu
    Department of Gastrointestinal Surgery, Graduate School of Medicine, The University of Tokyo
    Nihon Rinsho 63:478-81. 2005
  68. doi request reprint MyD88-induced downregulation of IRAK-4 and its structural requirements
    Fumihiko Hatao
    Department of Metabolic Care and Gastrointestinal Surgery, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    FEMS Immunol Med Microbiol 53:260-4. 2008
    ..These results demonstrate that downregulation of IRAK-4 requires activation of the MyD88-dependent pathway and that the death domains of both MyD88 and IRAK-4 are important for this downregulation...
  69. ncbi request reprint The pathological findings of vasculitis simultaneously occurring with carcinoma, invasive breast carcinoma in a patient with Behçet's disease
    Makoto Kammori
    Division of Breast and Endocrine Surgery, Department of Surgery, The University of Tokyo, 7 3 1, Hongo, Bunkyo ku, Tokyo, Japan
    Breast Cancer 13:378-81. 2006
    ..At 10 months follow-up the patient remains disease free. Malignancies associated with BD are very uncommon. The pathological findings showed small vessel vasculitis and lobulitis of the breast in association with invasive carcinoma...
  70. ncbi request reprint Decreased expression of the seven ARP2/3 complex genes in human gastric cancers
    Atsushi Kaneda
    National Cancer Center Research Institute, Chuo Ku, Tokyo, Japan
    Cancer Lett 212:203-10. 2004
    ..The consistent decrease of the Arp2/3 complex genes and its important role in actin organization suggested that the decrease could be involved in cancer phenotypes, such as dysplastic morphology...
  71. ncbi request reprint Sublethal endotoxin administration evokes super-resistance to systemic hypoxia in rats
    Naoki Hiki
    Department of Gastrointestinal Surgery, University of Tokyo, Japan
    J Trauma 54:584-9. 2003
    ....
  72. ncbi request reprint Expression of human telomerase reverse transcriptase gene and protein, and of estrogen and progesterone receptors, in breast tumors: preliminary data from neo-adjuvant chemotherapy
    Makoto Kammori
    Division of Breast and Endocrine Surgery, Department of Surgery, Graduate School of Medicine, The University of Tokyo, Japan
    Int J Oncol 27:1257-63. 2005
    ..These results suggest that detection of hTERT protein by ICH can be used to distinguish breast cancers as a potential diagnostic and therapeutic marker...
  73. ncbi request reprint [Perspectives on the standardization of surgical treatment for gastric cancer]
    Michio Kaminishi
    Department of Gastrointestinal Surgery, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Nihon Geka Gakkai Zasshi 104:395-8. 2003
    ..The standardization of surgical treatment of gastric cancer based on the estimation of these three aspects may offer a better prognosis and better QOL after gastrectomy...
  74. ncbi request reprint Association of spasmolytic polypeptide-expressing metaplasia with carcinogen administration and oxyntic atrophy in rats
    Hirokazu Yamaguchi
    Department of Gastrointestinal Surgery, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Lab Invest 82:1045-52. 2002
    ..These findings support our hypothesis that SPEM develops from a second progenitor cell population, reflecting either the unmasking of a cryptic zone or transdifferentiation of chief cells...
  75. ncbi request reprint Reduced expression of the insulin-induced protein 1 and p41 Arp2/3 complex genes in human gastric cancers
    Atsushi Kaneda
    Carcinogenesis Division, National Cancer Center Research Institute, Tokyo, Japan
    Int J Cancer 100:57-62. 2002
    ..INSIG1 and p41-Arc are known to be involved in cellular differentiation and morphology, respectively, and it was suggested that their reduced expressions might be involved in gastric cancer development or progression...
  76. ncbi request reprint Gastric cancer with metastasis to the gingiva
    Shouji Shimoyama
    Department of Gastrointestinal Surgery, University of Tokyo, Tokyo, Japan
    J Gastroenterol Hepatol 19:831-5. 2004
    ..Hematogenous spread could be a mechanism of metastasis for this unusual tumor...
  77. ncbi request reprint Results of a phase I clinical study using dendritic cell vaccinations for thyroid cancer
    Koichiro Kuwabara
    Department of Advanced Medical Science, Institute of Medical Science, University of Tokyo, Tokyo, Japan
    Thyroid 17:53-8. 2007
    ..We assessed the feasibility and efficacy of dendritic cell (DC) therapy for advanced thyroid papillary and follicular cancer...
  78. ncbi request reprint The induction of super-resistance using synthetic lipopolysaccharide receptor agonist rescues fatal endotoxemia in rats without excessive immunosuppression
    Fumihiko Hatao
    Department of Metabolic Care and Gastrointestinal Surgery, Graduate School of Medicine, University of Tokyo, Tokyo 113 8655, Japan
    Shock 23:365-70. 2005
    ..These results indicate that pretreatment with ER can effectively induce endotoxin tolerance, with a consequent improvement in mortality without toxicity and without subsequent excessive immunosuppression...
  79. ncbi request reprint [Roles of PPARs in carcinogenesis]
    Kazuhiro Imamura
    Department of Gastrointestinal Surgery, Surgical Science, Graduate School of Medicine, The University of Tokyo
    Nihon Rinsho 63:584-8. 2005
    ..So we expect the development of new PPARgamma ligands, which are more selective and powerful for PPARgamma, to break through the difficulties of PPARgamma ligands' use clinically...
  80. ncbi request reprint Prolonged Toll-like receptor stimulation leads to down-regulation of IRAK-4 protein
    Fumihiko Hatao
    National Institute of Health Sciences, Setagaya, Tokyo, Japan
    J Leukoc Biol 76:904-8. 2004
    ..These results indicate that prolonged stimulation of TLR2, TLR4, or TLR9 causes a down-regulation of IRAK-4 protein, which may be mediated through cleavage of IRAK-4 by a protease induced by the activation of nuclear factor-kappaB...
  81. ncbi request reprint Chemopreventive effect of peroxisome proliferator-activated receptor gamma on gastric carcinogenesis in mice
    Jie Lu
    Department of Gastrointestinal Surgery, Faculty of Medicine, University of Tokyo, Japan
    Cancer Res 65:4769-74. 2005
    ....
  82. ncbi request reprint Specific subtelomere loss on chromosome der(11)t(3;11)(q23;q23)x2 in anaplastic thyroid cancer cell line OCUT-1
    Makoto Kammori
    Division of Metabolic Care Unit and Endocrine Surgery, Department of Surgery, Graduate School of Medicine, The University of Tokyo, Bunkyo ku, Tokyo 113 8655, Japan
    Int J Mol Med 18:9-16. 2006
    ..Our findings suggest that telomere shortening and subtelomere loss are correlated with genetic instability in this anaplastic thyroid carcinoma cell line...
  83. ncbi request reprint Des-gamma carboxy prothrombin (PIVKA-II)- and alpha-fetoprotein (AFP)-producing gastric cancer
    Yoshihisa Takahashi
    J Gastroenterol 40:432-3. 2005
  84. ncbi request reprint Highly specific marker genes for detecting minimal gastric cancer cells in cytology negative peritoneal washings
    Kazuhiko Mori
    Genetics Division, National Cancer Center Research Institute, Tokyo 104 0045, Japan
    Biochem Biophys Res Commun 313:931-7. 2004
    ..The six newly identified recurrences included four non-peritoneal ones, showing that RT-PCR using the five genes without a real-time quantitative PCR technique contributes to the detection of minimal residual disease...
  85. ncbi request reprint Effect of early eradication on Helicobacter pylori-related gastric carcinogenesis in Mongolian gerbils
    Koji Nozaki
    Division of Oncological Pathology, Aichi Cancer Center Research Institute, Chikusa ku, Nagoya, Aichi 464 8681, Japan
    Cancer Sci 94:235-9. 2003
    ..Eradication at an early stage of inflammation might be effective in preventing Hp-related gastric carcinogenesis...
  86. ncbi request reprint Stomach-partitioning gastrojejunostomy for gastroduodenal outlet obstruction
    Keisuke Kubota
    Department of Surgery, International University of Health and Welfare Mita Hospital, Mita 1 4 3, Minato ku, Tokyo 108 8329, Japan
    Arch Surg 142:607-11; discussion 611. 2007
    ..The outcome of the stomach-partitioning gastrojejunostomy (SPGJ) procedure is superior to that of stenting procedures...
  87. ncbi request reprint Clinical application of human telomerase reverse transcriptase gene expression in thyroid follicular tumors by fine-needle aspirations using in situ hybridization
    Makoto Kammori
    Division of Breast Cancer Surgery, Department of Surgery, The University of Tokyo, Japan
    Int J Oncol 22:985-91. 2003
    ....
  88. ncbi request reprint Earlier Helicobacter pylori infection increases the risk for the N-methyl-N-nitrosourea-induced stomach carcinogenesis in Mongolian gerbils
    Xueyuan Cao
    Division of Oncological Pathology, Aichi Cancer Center Research Institute, Chikusa ku, Nagoya, Aichi 464 8681, Japan
    Jpn J Cancer Res 93:1293-8. 2002
    ..pylori significantly increases gastric chemical carcinogenesis with MNU, as compared to the case with later infection, possibly because of differences in host gastric mucosal factors and immunologic responses...
  89. ncbi request reprint Synergistic promoting effects of Helicobacter pylori infection and high-salt diet on gastric carcinogenesis in Mongolian gerbils
    Koji Nozaki
    Division of Oncological Pathology, Aichi Cancer Center Research Institute, 1 1 Kanokoden, Chikusa ku, Nagoya, Aichi 464 8681, Japan
    Jpn J Cancer Res 93:1083-9. 2002
    ..Moreover, Hp infection promoted gastric carcinomas more than the high-salt diet...
  90. ncbi request reprint Consistent decrease in telomere length in parathyroid tumors but alteration in telomerase activity limited to malignancies: preliminary report
    Makoto Kammori
    Department of Surgery, Endocrine and Metabolic Unit, The University of Tokyo, 3 28 6 Mejirodai, Bunkyo ku, Tokyo 112 8688, Japan
    World J Surg 26:1083-7. 2002
    ..23 +/- 0.86 kbp compared with the 12.61 +/- 0.81 kbp for the 16 age-matched subjects (p = 0.002). The results indicate that telomerase activity and telomere length may reflect the biologic behavior of individual parathyroid lesions...
  91. ncbi request reprint Expression and prognostic significance of prothymosin-alpha and ERp57 in human gastric cancer
    Charles M Leys
    Department of Surgery, Vanderbilt University School of Medicine, Nashville, TN 37232 2733, USA
    Surgery 141:41-50. 2007
    ..In this paper we assess whether the expression of these putative biomarkers in humans is correlated with gastric metaplasia and adenocarcinoma and clinical outcomes...
  92. ncbi request reprint [Gastric cancer and eradication of H. pylori]
    Michio Kaminishi
    Dept of Gastrointestinal Surgery, Graduate School of Medicine, The University of Tokyo
    Gan To Kagaku Ryoho 34:11-5. 2007
    ..The issues to be solved are to select the candidates for eradication and to assess the timing of eradication. Development of new diagnostic methods and biomarkers for H. pylori eradication is required...
  93. ncbi request reprint Inflammatory fibroid polyps of the stomach and Helicobacter pylori
    Nobuyuki Matsuhashi
    J Gastroenterol Hepatol 19:346-7. 2004
  94. pmc ARK5 expression in colorectal cancer and its implications for tumor progression
    Gen Ichi Kusakai
    Investigative Treatment Division, National Cancer Center, Research Institute East, Kashiwa, Chiba, Japan
    Am J Pathol 164:987-95. 2004
    ..In situ hybridization analysis showed ARK5 overexpression in tumor cells. Based on these findings, we propose that ARK5 overexpression is involved in tumor progression of colon cancer clinically...
  95. ncbi request reprint Gastric and intestinal phenotypes and histogenesis of advanced glandular stomach cancers in carcinogen-treated, Helicobacter pylori-infected Mongolian gerbils
    Tsutomu Mizoshita
    Division of Oncological Pathology, Aichi Cancer Center Research Institute, 1 1 Kanokoden, Chikusa ku, Nagoya 464 8681, Japan
    Cancer Sci 97:38-44. 2006
    ..Thus, it might be proposed that intestinal metaplasia is a paracancerous phenomenon rather than a premalignant condition. H. pylori infection may trigger intestinalization of both stomach cancers and non-neoplastic mucosa...
  96. ncbi request reprint Treatment results of preoperative concurrent chemoradiotherapy followed by surgery for stage III or IV esophageal squamous cell carcinoma
    Hideomi Yamashita
    Department of Radiology, University of Tokyo Hospital, Japan
    Radiat Med 24:65-71. 2006
    ..To evaluate the treatment outcome of preoperative neoadjuvant radiotherapy combined with chemotherapy (CTx) for 17 esophageal cancer patients...
  97. ncbi request reprint Meeting report of the 76th Congress of the Japanese Gastric Cancer Association
    Nobuaki Kaibara
    Gastric Cancer 7:185-95. 2004
  98. ncbi request reprint Eradication of Helicobacter pylori induces apoptosis and inhibits proliferation of heterotopic proliferative glands in infected Mongolian gerbils
    Xueyuan Cao
    Division of Oncological Pathology, Aichi Cancer Center Research Institute, Aichi 464 8681
    Cancer Sci 95:872-7. 2004
    ..These findings demonstrated that eradication results in apoptosis and reduction of proliferation of HPGs in H. pylori-infected gerbils, these lesions thus being apparently reversible through regulation of cell kinetics...
  99. ncbi request reprint Expression of Pdx-1 in human gastric metaplasia and gastric adenocarcinoma
    Charles M Leys
    Department of Surgery, Vanderbilt University School of Medicine, Nashville, TN 37232 2733, USA
    Hum Pathol 37:1162-8. 2006
    ..Given the pattern of normal Pdx-1 expression in the duodenum, goblet cell metaplasia in the stomach may reflect the adoption of a duodenal lineage paradigm...
  100. ncbi request reprint [Successful downstaging by a low-dose, fractional administration of irinotecan hydrochloride (CPT-11) in combination with cisplatin in peritoneal lavage cytology positive, 5-fluorouracil refractory advanced gastric cancer patients]
    Shouji Shimoyama
    Dept of Gastrointestinal Surgery, University of Tokyo
    Gan To Kagaku Ryoho 31:929-32. 2004
    ..This suggests that this combination could be an effective regimen for potentially disseminated, 5-FU resistant patients...
  101. ncbi request reprint Helicobacter pylori infection stimulates intestinalization of endocrine cells in glandular stomach of Mongolian gerbils
    Yoshiharu Takenaka
    Division of Oncological Pathology, Aichi Cancer Center Research Institute, 1 1 Kanokoden, Chikusa, Nagoya, Japan
    Cancer Sci 97:1015-22. 2006
    ..pylori-infected Mongolian gerbil stomach, supporting the concept that development of intestinal metaplasia is due to the abnormal differentiation of a stem cell...