Kousei Ito

Summary

Affiliation: University of Tokyo
Country: Japan

Publications

  1. doi request reprint Analysis and prediction of drug transfer into human milk taking into consideration secretion and reuptake clearances across the mammary epithelia
    Hiroki Koshimichi
    Department of Pharmacy, The University of Tokyo Hospital, Faculty of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Drug Metab Dispos 39:2370-80. 2011
  2. ncbi request reprint ABCC2/Abcc2 transport property in different species and its modulation by heterogeneous factors
    Kousei Ito
    Department of Pharmacy, The University of Tokyo Hospital, The University of Tokyo, Japan
    Drug Metab Pharmacokinet 23:394-405. 2008
  3. ncbi request reprint Prediction of in vivo biliary clearance from the in vitro transcellular transport of organic anions across a double-transfected Madin-Darby canine kidney II monolayer expressing both rat organic anion transporting polypeptide 4 and multidrug resistance as
    Makoto Sasaki
    Department of Biopharmaceutics, School of Pharmaceutical Sciences, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Mol Pharmacol 66:450-9. 2004
  4. doi request reprint Functional analysis of nonsynonymous single nucleotide polymorphism type ATP-binding cassette transmembrane transporter subfamily C member 3
    Kazuhiro Kobayashi
    Department of Pharmacy, The University of Tokyo Hospital, Faculty of Medicine, The University of Tokyo, Tokyo, Japan
    Pharmacogenet Genomics 18:823-33. 2008
  5. doi request reprint Receptor for activated C-kinase 1 regulates the cell surface expression and function of ATP binding cassette G2
    Yuki Ikebuchi
    Department of Pharmacy, The University of Tokyo Hospital, Faculty of Medicine, The University of Tokyo, Tokyo, Japan
    Drug Metab Dispos 38:2320-8. 2010
  6. doi request reprint Characterization of inhibitory effect of carbapenem antibiotics on the deconjugation of valproic acid glucuronide
    Yusuke Masuo
    The University of Tokyo Hospital, Faculty of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, Japan
    Drug Metab Dispos 38:1828-35. 2010
  7. ncbi request reprint Receptor for activated C-kinase 1 regulates the cellular localization and function of ABCB4
    Yuki Ikebuchi
    Department of Pharmacy, The University of Tokyo Hospital, Faculty of Medicine, The University of Tokyo, Bunkyo ku, Japan
    Hepatol Res 39:1091-107. 2009
  8. ncbi request reprint Functional involvement of rat organic anion transporter 3 (rOat3; Slc22a8) in the renal uptake of organic anions
    Maki Hasegawa
    Graduate School of Pharmaceutical Sciences, University of Tokyo, Hongo, Bunkyo ku, Tokyo, Japan
    J Pharmacol Exp Ther 300:746-53. 2002
  9. doi request reprint Posttranslational regulation of Abcc2 expression by SUMOylation system
    Satoko Minami
    Department of Pharmacy, The University of Tokyo Hospital, Faculty of Medicine, The University of Tokyo, Tokyo, Japan
    Am J Physiol Gastrointest Liver Physiol 296:G406-13. 2009
  10. doi request reprint Itraconazole-induced cholestasis: involvement of the inhibition of bile canalicular phospholipid translocator MDR3/ABCB4
    Takashi Yoshikado
    Department of Pharmacy, University of Tokyo Hospital, Faculty of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Mol Pharmacol 79:241-50. 2011

Collaborators

Detail Information

Publications12

  1. doi request reprint Analysis and prediction of drug transfer into human milk taking into consideration secretion and reuptake clearances across the mammary epithelia
    Hiroki Koshimichi
    Department of Pharmacy, The University of Tokyo Hospital, Faculty of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Drug Metab Dispos 39:2370-80. 2011
    ..9% of the drugs analyzed. The method described herein therefore may be useful in predicting drug concentration-time profiles in human milk for newly developed drugs...
  2. ncbi request reprint ABCC2/Abcc2 transport property in different species and its modulation by heterogeneous factors
    Kousei Ito
    Department of Pharmacy, The University of Tokyo Hospital, The University of Tokyo, Japan
    Drug Metab Pharmacokinet 23:394-405. 2008
    ..I will present an overview of the species differences in the tissue distribution, function, and also characteristic transport properties of ABCC2/Abcc2 mainly in an in vitro experimental model...
  3. ncbi request reprint Prediction of in vivo biliary clearance from the in vitro transcellular transport of organic anions across a double-transfected Madin-Darby canine kidney II monolayer expressing both rat organic anion transporting polypeptide 4 and multidrug resistance as
    Makoto Sasaki
    Department of Biopharmaceutics, School of Pharmaceutical Sciences, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Mol Pharmacol 66:450-9. 2004
    ..The double-transfected MDCK II monolayer may be useful in analyzing the hepatic vectorial transport of organic anions and in predicting in vivo biliary clearance...
  4. doi request reprint Functional analysis of nonsynonymous single nucleotide polymorphism type ATP-binding cassette transmembrane transporter subfamily C member 3
    Kazuhiro Kobayashi
    Department of Pharmacy, The University of Tokyo Hospital, Faculty of Medicine, The University of Tokyo, Tokyo, Japan
    Pharmacogenet Genomics 18:823-33. 2008
    ..In this study, we analyzed the functional properties of 11 nonsynonymous single nucleotide polymorphisms (SNPs) in the ABCC3 gene found in the public SNP database...
  5. doi request reprint Receptor for activated C-kinase 1 regulates the cell surface expression and function of ATP binding cassette G2
    Yuki Ikebuchi
    Department of Pharmacy, The University of Tokyo Hospital, Faculty of Medicine, The University of Tokyo, Tokyo, Japan
    Drug Metab Dispos 38:2320-8. 2010
    ....
  6. doi request reprint Characterization of inhibitory effect of carbapenem antibiotics on the deconjugation of valproic acid glucuronide
    Yusuke Masuo
    The University of Tokyo Hospital, Faculty of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, Japan
    Drug Metab Dispos 38:1828-35. 2010
    ....
  7. ncbi request reprint Receptor for activated C-kinase 1 regulates the cellular localization and function of ABCB4
    Yuki Ikebuchi
    Department of Pharmacy, The University of Tokyo Hospital, Faculty of Medicine, The University of Tokyo, Bunkyo ku, Japan
    Hepatol Res 39:1091-107. 2009
    ..Conclusion: These results suggest that RACK1 may have a functional significance as a regulatory cofactor of ABCB4 and is indispensable for the plasma membrane localization and translocation function of ABCB4...
  8. ncbi request reprint Functional involvement of rat organic anion transporter 3 (rOat3; Slc22a8) in the renal uptake of organic anions
    Maki Hasegawa
    Graduate School of Pharmaceutical Sciences, University of Tokyo, Hongo, Bunkyo ku, Tokyo, Japan
    J Pharmacol Exp Ther 300:746-53. 2002
    ..These results suggest that rOat1 and rOat3 are mainly responsible for the renal uptake of PAH and pravastatin, respectively...
  9. doi request reprint Posttranslational regulation of Abcc2 expression by SUMOylation system
    Satoko Minami
    Department of Pharmacy, The University of Tokyo Hospital, Faculty of Medicine, The University of Tokyo, Tokyo, Japan
    Am J Physiol Gastrointest Liver Physiol 296:G406-13. 2009
    ..This is the first demonstration showing the regulation of ABC transporter expression by SUMOylation...
  10. doi request reprint Itraconazole-induced cholestasis: involvement of the inhibition of bile canalicular phospholipid translocator MDR3/ABCB4
    Takashi Yoshikado
    Department of Pharmacy, University of Tokyo Hospital, Faculty of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Mol Pharmacol 79:241-50. 2011
    ..Our approach may be useful for analyzing mechanisms of drug-induced cholestasis and evaluating the cholestatic potential of clinically used drugs and drug candidates...
  11. ncbi request reprint Cholesterol-lowering effect of ezetimibe in uridine diphosphate glucuronosyltransferase 1A-deficient (Gunn) rats
    Takehito Yamamoto
    Department of Pharmacy, The University of Tokyo Hospital, Faculty of Medicine, The University of Tokyo, Tokyo 113 8655, Japan
    Drug Metab Dispos 35:1455-8. 2007
    ..001 approximately 0.3 mg/kg. These results indicate that a deficiency of UGT1A activity does not necessarily alter the cholesterol-lowering effect of EZE in rats at therapeutic doses...
  12. ncbi request reprint Transcellular transport of organic anions across a double-transfected Madin-Darby canine kidney II cell monolayer expressing both human organic anion-transporting polypeptide (OATP2/SLC21A6) and Multidrug resistance-associated protein 2 (MRP2/ABCC2)
    Makoto Sasaki
    Department of Biopharmaceutics, School of Pharmaceutical Sciences, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    J Biol Chem 277:6497-503. 2002
    ..The double-transfected MDCK II monolayer expressing both OATP2 and MRP2 may be used to analyze the hepatic vectorial transport of organic anions and to screen the transport profiles of new drug candidates...