Nobukazu Ishizaka

Summary

Affiliation: University of Tokyo
Country: Japan

Publications

  1. ncbi request reprint Is metabolic syndrome a risk factor for carotid atherosclerosis in normotensive and prehypertensive individuals?
    Nobukazu Ishizaka
    Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, Hongo, Toyko, Japan
    J Atheroscler Thromb 14:72-7. 2007
  2. ncbi request reprint Administration of ANG II induces iron deposition and upregulation of TGF-beta1 mRNA in the rat liver
    Nobukazu Ishizaka
    Department of Cardiovascular Medicine, University of Tokyo, Graduate School of Medicine, Hongo 7 3 1, Bunkyo ku, Tokyo 113 8655, Japan
    Am J Physiol Regul Integr Comp Physiol 288:R1063-70. 2005
  3. ncbi request reprint Iron dextran causes renal iron deposition but not renal dysfunction in angiotensin II-treated and untreated rats
    Nobukazu Ishizaka
    Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, Tokyo, Japan
    Nephron Physiol 98:p107-13. 2004
  4. ncbi request reprint Association between serum uric acid, metabolic syndrome, and carotid atherosclerosis in Japanese individuals
    Nobukazu Ishizaka
    Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, Tokyo, Japan
    Arterioscler Thromb Vasc Biol 25:1038-44. 2005
  5. ncbi request reprint Hypertension is the most common component of metabolic syndrome and the greatest contributor to carotid arteriosclerosis in apparently healthy Japanese individuals
    Nobukazu Ishizaka
    Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, Tokyo, Japan
    Hypertens Res 28:27-34. 2005
  6. ncbi request reprint Iron chelation suppresses ferritin upregulation and attenuates vascular dysfunction in the aorta of angiotensin II-infused rats
    Nobukazu Ishizaka
    Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, Hongo 7 3 1, Tokyo 113 8655, Japan
    Arterioscler Thromb Vasc Biol 25:2282-8. 2005
  7. ncbi request reprint Association between smoking, hematological parameters, and metabolic syndrome in Japanese men
    Nobukazu Ishizaka
    Department of Cardiovascular Medicine, University of Tokyo, Hongo 7 3 1 Bunkyo ku, Tokyo 113 8655, Japan
    Diabetes Care 29:741. 2006
  8. ncbi request reprint Higher serum uric acid is associated with increased arterial stiffness in Japanese individuals
    Nobukazu Ishizaka
    Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, Tokyo, Japan
    Atherosclerosis 192:131-7. 2007
  9. ncbi request reprint Metabolic syndrome may not associate with carotid plaque in subjects with optimal, normal, or high-normal blood pressure
    Nobukazu Ishizaka
    Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, Hongo 7 3 1 Bunkyo ku, Tokyo 113 8655, Japan
    Hypertension 48:411-7. 2006
  10. ncbi request reprint Association between serum albumin, carotid atherosclerosis, and metabolic syndrome in Japanese individuals
    Nobukazu Ishizaka
    Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, Tokyo, Japan
    Atherosclerosis 193:373-9. 2007

Collaborators

Detail Information

Publications77

  1. ncbi request reprint Is metabolic syndrome a risk factor for carotid atherosclerosis in normotensive and prehypertensive individuals?
    Nobukazu Ishizaka
    Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, Hongo, Toyko, Japan
    J Atheroscler Thromb 14:72-7. 2007
    ..We have investigated whether metabolic syndrome is a risk factor for carotid atherosclerosis also in normotensive or prehypertensive individuals...
  2. ncbi request reprint Administration of ANG II induces iron deposition and upregulation of TGF-beta1 mRNA in the rat liver
    Nobukazu Ishizaka
    Department of Cardiovascular Medicine, University of Tokyo, Graduate School of Medicine, Hongo 7 3 1, Bunkyo ku, Tokyo 113 8655, Japan
    Am J Physiol Regul Integr Comp Physiol 288:R1063-70. 2005
    ..Taken together, our data suggest that ANG II infusion induces aberrant iron homeostasis in the liver, which may have a role in the ANG II-induced upregulation of profibrotic gene expression in the liver...
  3. ncbi request reprint Iron dextran causes renal iron deposition but not renal dysfunction in angiotensin II-treated and untreated rats
    Nobukazu Ishizaka
    Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, Tokyo, Japan
    Nephron Physiol 98:p107-13. 2004
    ..We have investigated whether administration of iron mimics the renal damage induced by angiotensin II...
  4. ncbi request reprint Association between serum uric acid, metabolic syndrome, and carotid atherosclerosis in Japanese individuals
    Nobukazu Ishizaka
    Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, Tokyo, Japan
    Arterioscler Thromb Vasc Biol 25:1038-44. 2005
    ....
  5. ncbi request reprint Hypertension is the most common component of metabolic syndrome and the greatest contributor to carotid arteriosclerosis in apparently healthy Japanese individuals
    Nobukazu Ishizaka
    Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, Tokyo, Japan
    Hypertens Res 28:27-34. 2005
    ..These data emphasize the importance of controlling blood pressure for reducing the risk of both metabolic syndrome and carotid arteriosclerosis in apparently healthy individuals...
  6. ncbi request reprint Iron chelation suppresses ferritin upregulation and attenuates vascular dysfunction in the aorta of angiotensin II-infused rats
    Nobukazu Ishizaka
    Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, Hongo 7 3 1, Tokyo 113 8655, Japan
    Arterioscler Thromb Vasc Biol 25:2282-8. 2005
    ....
  7. ncbi request reprint Association between smoking, hematological parameters, and metabolic syndrome in Japanese men
    Nobukazu Ishizaka
    Department of Cardiovascular Medicine, University of Tokyo, Hongo 7 3 1 Bunkyo ku, Tokyo 113 8655, Japan
    Diabetes Care 29:741. 2006
  8. ncbi request reprint Higher serum uric acid is associated with increased arterial stiffness in Japanese individuals
    Nobukazu Ishizaka
    Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, Tokyo, Japan
    Atherosclerosis 192:131-7. 2007
    ..These data suggest that in both genders, serum uric acid level is associated with increased baPWV, a marker of arterial stiffness, and is in part independent of other conventional risk factors for atherosclerosis and metabolic syndrome...
  9. ncbi request reprint Metabolic syndrome may not associate with carotid plaque in subjects with optimal, normal, or high-normal blood pressure
    Nobukazu Ishizaka
    Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, Hongo 7 3 1 Bunkyo ku, Tokyo 113 8655, Japan
    Hypertension 48:411-7. 2006
    ..Thus, presence of metabolic syndrome may not increase the prevalence of carotid atherosclerosis independent of other cardiovascular risk factors in Japanese individuals with optimal, normal, or high-normal blood pressure...
  10. ncbi request reprint Association between serum albumin, carotid atherosclerosis, and metabolic syndrome in Japanese individuals
    Nobukazu Ishizaka
    Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, Tokyo, Japan
    Atherosclerosis 193:373-9. 2007
    ..Whether these observations are in part explained by the antioxidative properties of albumin requires further investigation...
  11. ncbi request reprint Expression and localization of PDGF-B, PDGF-D, and PDGF receptor in the kidney of angiotensin II-infused rat
    Nobukazu Ishizaka
    Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, Tokyo, Japan
    Lab Invest 86:1285-92. 2006
    ....
  12. ncbi request reprint Relationship between smoking, white blood cell count and metabolic syndrome in Japanese women
    Nobukazu Ishizaka
    Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, Hongo 7 3 1, Tokyo, Japan
    Diabetes Res Clin Pract 78:72-6. 2007
    ..These data collectively suggested that the association between current smoking and metabolic syndrome is heavily confounded by certain factors that increase the circulating white blood cell count in Japanese women, as in men...
  13. ncbi request reprint Angiotensin II-induced regulation of the expression and localization of iron metabolism-related genes in the rat kidney
    Nobukazu Ishizaka
    Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, Japan
    Hypertens Res 30:195-202. 2007
    ..The relative contribution, if any, of these genes to renal and/or whole-body iron homeostasis in various disorders in which the renin angiotensin system is activated should be investigated in future studies...
  14. ncbi request reprint Increased leukotriene A(4) hydrolase expression in the heart of angiotensin II-induced hypertensive rat
    N Ishizaka
    Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, Hongo 7 3 1, Bunkyo ku, Tokyo, Japan
    FEBS Lett 463:155-9. 1999
    ..These data suggest that the cardiac LTA(4) hydrolase-LTB(4) system plays a positive role in the promotion of cardiac inflammation in hypertension...
  15. ncbi request reprint Association between cigarette smoking, white blood cell count, and metabolic syndrome as defined by the Japanese criteria
    Nobukazu Ishizaka
    Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine
    Intern Med 46:1167-70. 2007
    ..We investigated the association between cigarette smoking, WBC count, and metabolic syndrome as defined by the Japanese criteria...
  16. ncbi request reprint Are serum carcinoembryonic antigen levels associated with carotid atherosclerosis in Japanese men?
    Nobukazu Ishizaka
    Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, Hongo 7 3 1 Bunkyo ku, Tokyo 113 8655, Japan
    Arterioscler Thromb Vasc Biol 28:160-5. 2008
    ..We have investigated whether serum CEA levels are associated with early carotid atherosclerosis...
  17. doi request reprint Association between chronic kidney disease and carotid intima-media thickening in individuals with hypertension and impaired glucose metabolism
    Nobukazu Ishizaka
    Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, Tokyo, Japan
    Hypertens Res 30:1035-41. 2007
    ....
  18. doi request reprint Association between obesity and chronic kidney disease in Japanese: differences in gender and hypertensive status?
    Nobukazu Ishizaka
    Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, Tokyo, Japan
    Hypertens Res 30:1059-64. 2007
    ....
  19. doi request reprint Relationship between albuminuria, low eGFR, and carotid atherosclerosis in Japanese women
    Yuko Ishizaka
    Center for Multiphasic Health Testing and Services, Mitsui Memorial Hospital, Tokyo, Japan
    Kidney Blood Press Res 31:164-70. 2008
    ..In conclusion, in Japanese women who underwent general health screening, albuminuria, but not low eGFR, was positively associated with carotid plaque...
  20. doi request reprint Association between cigarette smoking and chronic kidney disease in Japanese men
    Nobukazu Ishizaka
    Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, and Center for Multiphasic Health Testing and Services, Mitsui Memorial Hospital, Tokyo, Japan
    Hypertens Res 31:485-92. 2008
    ....
  21. doi request reprint Association between metabolic syndrome and carotid atherosclerosis in individuals without diabetes based on the oral glucose tolerance test
    Nobukazu Ishizaka
    Department of Cardiovascular Medicine, University of Tokyo, Graduate School of Medicine, Hongo 7 3 1 Bunkyo ku, Tokyo 113 8655, Japan
    Atherosclerosis 204:619-23. 2009
    ..We investigated whether metabolic syndrome is associated with carotid atherosclerosis in individuals who were shown not to have diabetes mellitus based on results of the 75-g oral glucose tolerance test (OGTT)...
  22. doi request reprint Impacts of changes in obesity parameters for the prediction of blood pressure change in Japanese individuals
    Nobukazu Ishizaka
    Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, Tokyo, Japan
    Kidney Blood Press Res 32:421-7. 2009
    ..The %dWC, %dBMI, and %dBPs was defined as (WC2 - WC1)/WC1 x 100, (BMI2 - BMI1)/BMI1 x 100, and (BPs2 - BPs1)/BPs1 x 100, respectively...
  23. doi request reprint Changes in waist circumference and body mass index in relation to changes in serum uric acid in Japanese individuals
    Nobukazu Ishizaka
    Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, Bunkyo ku, Tokyo, Japan
    J Rheumatol 37:410-6. 2010
    ..We investigated the relationship among percentage changes in waist circumference (%dWC), body mass index (%dBMI), and serum uric acid (%dUA)...
  24. ncbi request reprint Impact of changes in waist circumference and BMI over one-year period on serum lipid data in Japanese individuals
    Nobukazu Ishizaka
    Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, Japan
    J Atheroscler Thromb 16:764-71. 2009
    ..We therefore analyzed the impact of changes in WC and BMI over a one-year period on serum levels of LDL cholesterol (LDL-C), HDL cholesterol (HDL-C), and triglycerides (TG)...
  25. doi request reprint Effects of the AT(1) receptor blocker losartan and the calcium channel blocker benidipine on the accumulation of lipids in the kidney of a rat model of metabolic syndrome
    Nobukazu Ishizaka
    Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, Hongo, Tokyo, Japan
    Hypertens Res 33:263-8. 2010
    ....
  26. ncbi request reprint Abnormal iron deposition in renal cells in the rat with chronic angiotensin II administration
    Nobukazu Ishizaka
    Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, Hongo 7 3 1, Bunkyo ku, Tokyo 113 8655, Japan
    Lab Invest 82:87-96. 2002
    ..These results suggest that angiotensin II causes renal injury, in part, by inducing the deposition of iron in the kidney...
  27. ncbi request reprint Iron overload augments angiotensin II-induced cardiac fibrosis and promotes neointima formation
    Nobukazu Ishizaka
    Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, Japan
    Circulation 106:1840-6. 2002
    ..In the present study, we investigated the role of iron in the development of cardiac injury induced by angiotensin II...
  28. ncbi request reprint Increased prevalence of carotid atherosclerosis in hepatitis B virus carriers
    Nobukazu Ishizaka
    Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, Japan
    Circulation 105:1028-30. 2002
    ..We have investigated the possible association between hepatitis B virus surface antigen (HBsAg) positivity and carotid arteriosclerosis...
  29. ncbi request reprint Association between insulin resistance and carotid arteriosclerosis in subjects with normal fasting glucose and normal glucose tolerance
    Nobukazu Ishizaka
    Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, Japan
    Arterioscler Thromb Vasc Biol 23:295-301. 2003
    ..We examined the possible association between insulin resistance and carotid arteriosclerosis in subjects who had both normal fasting glucose and normal glucose tolerance after intake of a glucose load...
  30. ncbi request reprint Regulation and localization of HSP70 and HSP25 in the kidney of rats undergoing long-term administration of angiotensin II
    Nobukazu Ishizaka
    Department of Cardiovascular Medicine, University of Tokyo, Graduate School of Medicine, Tokyo, Japan
    Hypertension 39:122-8. 2002
    ..Our data show that Ang II infusion induces renal HSP70 and HSP25, as well as HO-1, and that Ang II can induce expression of these HSPs in renal cells in a pressor-independent manner...
  31. ncbi request reprint Heme oxygenase-1 is upregulated in the rat heart in response to chronic administration of angiotensin II
    N Ishizaka
    Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, Bunkyo ku, Tokyo 113 8655, Japan
    Am J Physiol Heart Circ Physiol 279:H672-8. 2000
    ..Our data suggest that angiotensin II upregulates cardiac HO-1 expression in the newly formed inflammatory lesion, which may represent an adaptive response to angiotensin II-induced cardiac damage...
  32. ncbi request reprint Association between white blood cell count and carotid arteriosclerosis in Japanese smokers
    Nobukazu Ishizaka
    Department of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo, Bunkyo ku Hongo 7 3 1, Tokyo 113 8655, Japan
    Atherosclerosis 175:95-100. 2004
    ..These data suggested the possible association between the circulating white blood cell count and formation of carotid plaque in male smokers, but not in male never smokers or in females, in an apparently healthy Japanese population...
  33. ncbi request reprint Iron chelation and a free radical scavenger suppress angiotensin II-induced upregulation of TGF-beta1 in the heart
    Kan Saito
    Dept of Cardiovascular Medicine, University of Tokyo, Graduate School of Medicine, Hongo 7 3 1, Bunkyo ku, Tokyo 113 8655, Japan
    Am J Physiol Heart Circ Physiol 288:H1836-43. 2005
    ....
  34. ncbi request reprint Role of aberrant iron homeostasis in the upregulation of transforming growth factor-beta1 in the kidney of angiotensin II-induced hypertensive rats
    Kan Saito
    Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, Japan
    Hypertens Res 27:599-607. 2004
    ..Collectively, these data suggest that the renal iron overload and presumed subsequent increase in oxidative stress play a role in angiotensin II-induced upregulation of the mRNAs of TGF-beta1 and collagen types I and IV in the kidney...
  35. doi request reprint Administration of angiotensin II, but not catecholamines, induces accumulation of lipids in the rat heart
    Makiko Hongo
    Department of Cardiovascular Medicine, University of Tokyo, Graduate School of Medicine, Hongo 7 3 1, Bunkyo ku, Tokyo 113 8655, Japan
    Eur J Pharmacol 604:87-92. 2009
    ....
  36. ncbi request reprint Iron chelation and a free radical scavenger suppress angiotensin II-induced downregulation of klotho, an anti-aging gene, in rat
    Kan Saito
    Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, Bunkyo ku Hongo 7 3 1, 113 8655 Tokyo, Japan
    FEBS Lett 551:58-62. 2003
    ..Collectively, these findings suggest that abnormal iron metabolism and increased oxidative stress are involved in the mechanism of angiotensin II-mediated modulation of klotho expression...
  37. ncbi request reprint Lipid accumulation and transforming growth factor-beta upregulation in the kidneys of rats administered angiotensin II
    Kan Saito
    Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, Tokyo, Japan
    Hypertension 46:1180-5. 2005
    ..Abnormal lipid metabolism may be associated with upregulation of TGF-beta1 expression and aberrant iron homeostasis in the kidneys of angiotensin II-infused animals...
  38. doi request reprint Comparison of vasculoprotective effects of benidipine and losartan in a rat model of metabolic syndrome
    Gen Matsuzaki
    Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, Japan
    Eur J Pharmacol 587:237-42. 2008
    ..These data suggest that, when used in an antihypertensive dose, benidipine is as effective as losartan in restoring vascular endothelial function and in suppressing of cardiovascular remodeling in an animal model of metabolic syndrome...
  39. ncbi request reprint Comparison of the impact of changes in waist circumference and body mass index in relation to changes in serum gamma-glutamyltransferase levels
    Aiko Sakamoto
    Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, Tokyo, Japan
    J Atheroscler Thromb 20:142-51. 2013
    ..Here, the relationship was analyzed between changes in obesity parameters and those in serum GGT over a one-year period...
  40. doi request reprint Association between changes in obesity parameters and incidence of chronic kidney disease in Japanese individuals
    Yuko Ishizaka
    Center for Multiphasic Health Testing and Services, Mitsui Memorial Hospital, Tokyo, Japan
    Kidney Blood Press Res 32:141-9. 2009
    ....
  41. ncbi request reprint Association between hepatitis C virus core protein and carotid atherosclerosis
    Yuko Ishizaka
    Center for Multiphasic Health Testing and Services, Mitsui Memorial Hospital, Tokyo, Japan
    Circ J 67:26-30. 2003
    ..61 (95% confidence interval 2.06-15.26, p<0.001). These data further support the possible link between persistent HCV infection and carotid atherosclerosis in the subjects without severe liver dysfunction...
  42. doi request reprint Relationship between blood pressure and chronic kidney disease in the Japanese population: the lower the better even in individuals without hypertension?
    Yasutomi Higashikuni
    Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, Tokyo, Japan
    Hypertens Res 31:213-9. 2008
    ..14), 2.59 (0.99-6.78), and 3.99 (1.50-10.64). Blood pressure was not significantly associated with low eGFR in either gender. The risk for albuminuria was significantly greater when blood pressure exceeded 110/75 mmHg in both genders...
  43. ncbi request reprint In vivo klotho gene transfer ameliorates angiotensin II-induced renal damage
    Haruo Mitani
    Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, Tokyo, Japan
    Hypertension 39:838-43. 2002
    ....
  44. ncbi request reprint Association between cigarette smoking, metabolic syndrome, and carotid arteriosclerosis in Japanese individuals
    Nobukazu Ishizaka
    Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, Bunkyo ku Hongo 7 3 1, Tokyo 113 8655, Japan
    Atherosclerosis 181:381-8. 2005
    ..92, P = 0.0023) and 1.57 (95% CI 1.22-2.03, P = 0.0005), respectively, in men. Collectively, these data suggest that the atherogenic consequences of smoking may, at least in part, be explained by its association with metabolic syndrome...
  45. ncbi request reprint Statins augment collateral growth in response to ischemia but they do not promote cancer and atherosclerosis
    Masataka Sata
    Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, Tokyo, Japan
    Hypertension 43:1214-20. 2004
    ..These results suggest that statins may not promote the development of cancer and atherosclerosis at the doses that augment collateral flow growth in ischemic tissues...
  46. doi request reprint Idiopathic retroperitoneal fibrosis, inflammatory aortic aneurysm, and inflammatory pericarditis--retrospective analysis of 11 case histories
    Aiko Sakamoto
    Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, Tokyo, Japan
    J Cardiol 59:139-46. 2012
    ....
  47. ncbi request reprint Impact of changes in obesity parameters on glucose metabolism and insulin resistance over a one-year period
    Aiko Sakamoto
    Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, Tokyo, Japan
    J Atheroscler Thromb 17:1246-55. 2010
    ..We have investigated the impact of changes in WC and in BMI on data related to glucose metabolism over a one-year period...
  48. doi request reprint Pioglitazone ameliorates systolic and diastolic cardiac dysfunction in rat model of angiotensin II-induced hypertension
    Aiko Sakamoto
    Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, Japan
    Int J Cardiol 167:409-15. 2013
    ....
  49. doi request reprint Reduction of renal lipid content and proteinuria by a PPAR-╬│ agonist in a rat model of angiotensin II-induced hypertension
    Aiko Sakamoto
    Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, Tokyo, Japan
    Eur J Pharmacol 682:131-6. 2012
    ..Reduction of lipotoxic renal damage may represent one of the renoprotective effects provided by pioglitazone in hypertension with activation of the renin-angiotensin system...
  50. doi request reprint Liver lipid content is reduced in rat given 7-day administration of angiotensin II
    Nobukazu Ishizaka
    Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, Tokyo, Japan
    J Renin Angiotensin Aldosterone Syst 12:462-8. 2011
    ..Angiotensin II reduced triglyceride content in the liver, unlike in the kidney or heart, via an AT1 receptor-dependent mechanism...
  51. ncbi request reprint Heme oxygenase-1 gene promoter polymorphism is associated with coronary artery disease in Japanese patients with coronary risk factors
    Hideaki Kaneda
    Department of Cardiovascular Medicine, The University of Tokyo, Graduate School of Medicine, Tokyo, Japan
    Arterioscler Thromb Vasc Biol 22:1680-5. 2002
    ..There is a strong link between oxidative stress and the pathogenesis of coronary artery disease (CAD)...
  52. ncbi request reprint Serum calcium concentration and carotid artery plaque: a population-based study
    Nobukazu Ishizaka
    Department of Cardiovascular Medicine, University of Tokyo, Graduate School of Medicine, Hongo 7 3 1, Bunkyo ku, Tokyo 113 8655
    J Cardiol 39:151-7. 2002
    ..However, only a few large-scale population studies have been performed to investigate the association between serum calcium and carotid plaque...
  53. ncbi request reprint Angiotensin II and catecholamines increase plasma levels of 8-epi-prostaglandin F(2alpha) with different pressor dependencies in rats
    Toru Aizawa
    Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, Japan
    Hypertension 39:149-54. 2002
    ..Ang II and norepinephrine seem to induce this increase in 8-epi-PGF(2alpha) via mechanisms with different pressor dependencies...
  54. ncbi request reprint Absence of p53 leads to accelerated neointimal hyperplasia after vascular injury
    Masataka Sata
    Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, Japan
    Arterioscler Thromb Vasc Biol 23:1548-52. 2003
    ..However, the role of p53 in cell proliferation and apoptosis in vascular lesions has been controversial...
  55. doi request reprint Relationship between serum IgG4 concentrations and atherosclerotic coronary plaques assessed by computed tomographic angiography
    Aiko Sakamoto
    Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, Tokyo, Japan Electronic address
    J Cardiol 67:254-61. 2016
    ..The aim of this study was to analyze the association of serum IgG4 concentrations with calcified and non-calcified coronary plaques...
  56. doi request reprint Pioglitazone Reduces Vascular Lipid Accumulation in Angiotensin II-Induced Hypertensive Rat
    Aiko Sakamoto
    Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine
    J Atheroscler Thromb 22:1225-34. 2015
    ..In the current study, we analyzed whether pioglitazone, an agonist of PPAR╬│, reduces angiotensin II-induced vascular lipid accumulation...
  57. doi request reprint Serum levels of IgG4 and soluble interleukin-2 receptor in patients with coronary artery disease
    Aiko Sakamoto
    Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, Japan
    Clin Chim Acta 413:577-81. 2012
    ..We investigated the association between serum concentrations of IgG4 or soluble interleukin-2 receptor (sIL-2R) and coronary artery disease (CAD)...
  58. doi request reprint A case of localized IgG4-related thoracic periarteritis and recurrent nerve palsy
    Masao Takahashi
    Department of Cardiovascular Medicine, The University of Tokyo, Hongo, Bunkyo ku, Japan
    Am J Med Sci 341:166-9. 2011
    ..This case suggests that IgG4-related periarteritis can also occur as a solitary focus in the cardiovascular system...
  59. ncbi request reprint Association between gamma-glutamyltransferase levels and insulin resistance according to alcohol consumption and number of cigarettes smoked
    Nobukazu Ishizaka
    Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, Tokyo, Japan
    J Atheroscler Thromb 17:476-85. 2010
    ..We analyzed the association between GGT and a marker of insulin resistance, homeostasis model assessment for insulin resistance (HOMA-IR), according to the drinking and smoking status...
  60. ncbi request reprint Different effects of angiotensin II and catecholamine on renal cell apoptosis and proliferation in rats
    T Aizawa
    Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, Tokyo, Japan
    Kidney Int 59:645-53. 2001
    ..The renal HO system may modulate proliferative and pro-apoptotic effects of Ang II...
  61. doi request reprint Giant tumorous lesions (correction of legions) surrounding the right coronary artery associated with immunoglobulin-G4-related systemic disease
    Masayasu Ikutomi
    Department of Cardiovascular Medicine, The University of Tokyo, Tokyo, Japan
    Cardiology 120:22-6. 2011
    ..This case emphasizes the importance of considering the diagnosis in any patient with abnormally increased wall thickness or ectatic lesions in the coronary arteries...
  62. ncbi request reprint Critical role of bone marrow angiotensin II type 1 receptor in the pathogenesis of atherosclerosis in apolipoprotein E deficient mice
    Daiju Fukuda
    Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Arterioscler Thromb Vasc Biol 28:90-6. 2008
    ..Recently, bone marrow (BM) cells were reported to express AT1R. Here, we investigated the role of AT1R in BM in the pathogenesis of atherosclerosis...
  63. ncbi request reprint Facilitated angiogenesis induced by heme oxygenase-1 gene transfer in a rat model of hindlimb ischemia
    Masatoshi Suzuki
    Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, Bunkyo ku Hongo 7 3 1, Tokyo 113 8655, Japan
    Biochem Biophys Res Commun 302:138-43. 2003
    ..Thus, HO-1 gene transfer improves the blood flow in ischemic hindlimb, at least in part, via angiogenesis facilitated by the induction of this molecule...
  64. doi request reprint The prevalence of malignant neoplastic and non-malignant gastrointestinal lesions in cardiology inpatients
    Aiko Sakamoto
    Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, Hongo 7 3 1, Tokyo 113 8655, Japan
    J Cardiol 61:181-5. 2013
    ....
  65. pmc LXR agonist increases apoE secretion from HepG2 spheroid, together with an increased production of VLDL and apoE-rich large HDL
    Makoto Kurano
    Department of Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, Tokyo 113 8655, Japan
    Lipids Health Dis 10:134. 2011
    ..The physiological regulation of hepatic apoE gene has not been clarified, although the expression of apoE in adipocytes and macrophages has been known to be regulated by LXR...
  66. ncbi request reprint Carbon monoxide protects against cardiac ischemia--reperfusion injury in vivo via MAPK and Akt--eNOS pathways
    Hajime Fujimoto
    Department of Cardiovascular Medicine, University of Tokyo, Japan
    Arterioscler Thromb Vasc Biol 24:1848-53. 2004
    ..Carbon monoxide (CO) is postulated to protect tissues against several types of injuries. We investigated the role of CO in amelioration of cardiac ischemia-reperfusion injury in vivo and the mechanisms involved in it...
  67. ncbi request reprint Efficacy of darbepoetin in doxorubicin-induced cardiorenal injury in rats
    Eisei Noiri
    Department of Nephrology and Endocrinology, Nephrology 107 Laboratory, Center for Dialysis, Apheresis, and Applied Medicine, University Hospital, Tokyo, Japan
    Nephron Exp Nephrol 104:e6-e14. 2006
    ..DA reduced the DXR-induced cardiorenal injury. This improvement was achieved, when anemia was corrected to the normal control level...
  68. ncbi request reprint Association between hepatitis B/C viral infection, chronic kidney disease and insulin resistance in individuals undergoing general health screening
    Nobukazu Ishizaka
    Departments of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, Hongo, Tokyo, Japan
    Hepatol Res 38:775-83. 2008
    ....
  69. ncbi request reprint 18F-fluorodeoxyglucose positron emission tomography in a case of retroperitoneal fibrosis
    Aiko Sakamoto
    Department of Cardiovascular Medicine, The University of Tokyo Graduate School of Medicine, Tokyo, Japan
    Int Heart J 47:645-50. 2006
    ..Two months after the initiation of corticosteroid therapy, the abnormal uptake of (18)F-FDG had ceased along with a reduction in the fibrous mass surrounding the abdominal aorta...
  70. ncbi request reprint [Angiotensin II regulates klotho gene expression]
    Nobukazu Ishizaka
    Department of Cardiovascular Medicine, University of Tokyo, Graduate School of Medicine
    Nihon Rinsho 60:1935-9. 2002
    ..Downregulation of the renal klotho gene may have a role in the development of angiotensin II-induced end organ damage...
  71. ncbi request reprint Mouse genetic evidence that tranilast reduces smooth muscle cell hyperplasia via a p21(WAF1)-dependent pathway
    Masataka Sata
    Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, Tokyo, Japan
    Arterioscler Thromb Vasc Biol 22:1305-9. 2002
    ..Despite clinical interest in this drug, the pharmacological actions of tranilast remain relatively unexplored at a molecular level...
  72. ncbi request reprint [Importance of smoking cessation intervention for subjects with metabolic syndrome]
    Yuko Ishizaka
    Center for Multiphasic Health Testing and Services, Mitsui Memorial Hospital
    Nihon Rinsho 64:589-93. 2006
  73. ncbi request reprint Balloon injury does not induce heme oxygenase-1 expression, but administration of hemin inhibits neointimal formation in balloon-injured rat carotid artery
    T Aizawa
    Faculty of Medicine, University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo, 113 8655, Japan
    Biochem Biophys Res Commun 261:302-7. 1999
    ..This study suggests that induction of the endogenous antioxidant gene can suppress neointimal formation after balloon injury...
  74. ncbi request reprint Lecithinized copper, zinc-superoxide dismutase ameliorates ischemia-induced myocardial damage
    H Nakajima
    Department of Cardiovascular Medicine, University of Tokyo, Graduate School of Medicine, Japan
    Life Sci 69:935-44. 2001
    ..Single bolus administration of lecithinized SOD had a cardioprotective effect against ischemia without reperfusion in the rat model of acute myocardial infarction, possibly due to its sustained high tissue concentration...
  75. ncbi request reprint Retroperitoneal fibrosis with periaortic and pericardial involvement
    Eisuke Amiya
    Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, Tokyo, Japan
    Circ J 69:760-2. 2005
    ..The relationship between loxoprofen, cardiomyopathy and RPF remains unclear. There is a possibility of RPF in the patients with a thickening of thoracic aortic wall, as in this case...
  76. ncbi request reprint Association between hepatitis C virus seropositivity, carotid-artery plaque, and intima-media thickening
    Nobukazu Ishizaka
    Lancet 359:133-5. 2002
    ..92 [95% CI 1.56-2.38], p=0.002) and carotid intima-media thickening (2.85 [2.28-3.57], p<0.0001). These findings suggest a possible role for chronic hepatitis C in the pathogenesis of carotid arterial remodelling...
  77. ncbi request reprint Comparison of several metabolic syndrome definitions with relation to early carotid atherosclerosis in Japanese men
    Nobukazu Ishizaka
    Atherosclerosis 195:e216-7; author reply e218-9. 2007