Hidenori Ichijo

Summary

Affiliation: University of Tokyo
Country: Japan

Publications

  1. doi request reprint Apoptosis signal-regulating kinase 1 as a therapeutic target
    Yosuke Kawarazaki
    The University of Tokyo, Graduate School of Pharmaceutical Sciences, Cell Signaling, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan 81 3 5841 4858 81 3 5841 4798
    Expert Opin Ther Targets 18:651-64. 2014
  2. pmc Oxidative Stress-Induced Diseases via the ASK1 Signaling Pathway
    Mayumi Soga
    Laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Int J Cell Biol 2012:439587. 2012
  3. ncbi request reprint [ASK family proteins in stress and disease--"how cells sense stress"]
    Hidenori Ichijo
    Nihon Yakurigaku Zasshi 129:89-93. 2007
  4. pmc The roles of ASK family proteins in stress responses and diseases
    Kazuki Hattori
    Laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Cell Commun Signal 7:9. 2009
  5. doi request reprint The Kelch repeat protein KLHDC10 regulates oxidative stress-induced ASK1 activation by suppressing PP5
    Yusuke Sekine
    Laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Mol Cell 48:692-704. 2012
  6. doi request reprint SOD1 as a molecular switch for initiating the homeostatic ER stress response under zinc deficiency
    Kengo Homma
    Laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, Global Center of Education and Research for Chemical Biology of the Diseases, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Mol Cell 52:75-86. 2013
  7. pmc ASK1 and ASK2 differentially regulate the counteracting roles of apoptosis and inflammation in tumorigenesis
    Takayuki Iriyama
    Laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan
    EMBO J 28:843-53. 2009
  8. pmc Thioredoxin and TRAF family proteins regulate reactive oxygen species-dependent activation of ASK1 through reciprocal modulation of the N-terminal homophilic interaction of ASK1
    Go Fujino
    Laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Mol Cell Biol 27:8152-63. 2007
  9. doi request reprint Involvement of ASK1-p38 pathway in the pathogenesis of diabetes triggered by pancreatic ß cell exhaustion
    Kiyoshi Yamaguchi
    The University of Tokyo, Bunkyo ku, Tokyo, Japan
    Biochim Biophys Acta 1830:3656-63. 2013
  10. pmc Mitochondrial phosphoglycerate mutase 5 uses alternate catalytic activity as a protein serine/threonine phosphatase to activate ASK1
    Kohsuke Takeda
    Laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, Global Center of Excellence Program, Japan Science and Technology Corporation, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Proc Natl Acad Sci U S A 106:12301-5. 2009

Detail Information

Publications115 found, 100 shown here

  1. doi request reprint Apoptosis signal-regulating kinase 1 as a therapeutic target
    Yosuke Kawarazaki
    The University of Tokyo, Graduate School of Pharmaceutical Sciences, Cell Signaling, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan 81 3 5841 4858 81 3 5841 4798
    Expert Opin Ther Targets 18:651-64. 2014
    ..ASK1 plays an important role in the response to reactive oxygen species (ROS), endoplasmic reticulum stress and pro-inflammatory cytokines, and it is involved in the pathogenesis of various diseases...
  2. pmc Oxidative Stress-Induced Diseases via the ASK1 Signaling Pathway
    Mayumi Soga
    Laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Int J Cell Biol 2012:439587. 2012
    ..In this review, we introduce recent findings of the regulatory mechanisms of ASK1 and the oxidative stress-induced diseases mediated by the ASK1 signaling pathway...
  3. ncbi request reprint [ASK family proteins in stress and disease--"how cells sense stress"]
    Hidenori Ichijo
    Nihon Yakurigaku Zasshi 129:89-93. 2007
  4. pmc The roles of ASK family proteins in stress responses and diseases
    Kazuki Hattori
    Laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Cell Commun Signal 7:9. 2009
    ..In this review, we summarize the recent findings on ASK family proteins and their implications in various diseases...
  5. doi request reprint The Kelch repeat protein KLHDC10 regulates oxidative stress-induced ASK1 activation by suppressing PP5
    Yusuke Sekine
    Laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Mol Cell 48:692-704. 2012
    ..These findings suggest that Slim/KLHDC10 is an activator of ASK1, contributing to oxidative stress-induced cell death through the suppression of PP5...
  6. doi request reprint SOD1 as a molecular switch for initiating the homeostatic ER stress response under zinc deficiency
    Kengo Homma
    Laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, Global Center of Education and Research for Chemical Biology of the Diseases, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Mol Cell 52:75-86. 2013
    ..We conclude that SOD1 has a function as a molecular switch that activates the ER stress response, which plays an important role in cellular homeostasis under zinc-deficient conditions. ..
  7. pmc ASK1 and ASK2 differentially regulate the counteracting roles of apoptosis and inflammation in tumorigenesis
    Takayuki Iriyama
    Laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan
    EMBO J 28:843-53. 2009
    ..In contrast, ASK1-dependent cytokine production in inflammatory cells promoted tumorigenesis. Our findings suggest that ASK1 and ASK2 are critically involved in tumorigenesis by differentially regulating apoptosis and inflammation...
  8. pmc Thioredoxin and TRAF family proteins regulate reactive oxygen species-dependent activation of ASK1 through reciprocal modulation of the N-terminal homophilic interaction of ASK1
    Go Fujino
    Laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Mol Cell Biol 27:8152-63. 2007
    ..Furthermore, the H2O2-induced interaction was reduced by double knockdown of TRAF2 and TRAF6. These findings demonstrate that Trx, TRAF2, and TRAF6 regulate ASK1 activity by modulating N-terminal homophilic interaction of ASK1...
  9. doi request reprint Involvement of ASK1-p38 pathway in the pathogenesis of diabetes triggered by pancreatic ß cell exhaustion
    Kiyoshi Yamaguchi
    The University of Tokyo, Bunkyo ku, Tokyo, Japan
    Biochim Biophys Acta 1830:3656-63. 2013
    ..Mutant Insulin 2 protein (Ins2(C96Y)) induces endoplasmic reticulum (ER) stress and pancreatic ß cell death in Akita mice, although the molecular mechanism of Ins(C96Y)-induced cell death remains unclear...
  10. pmc Mitochondrial phosphoglycerate mutase 5 uses alternate catalytic activity as a protein serine/threonine phosphatase to activate ASK1
    Kohsuke Takeda
    Laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, Global Center of Excellence Program, Japan Science and Technology Corporation, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Proc Natl Acad Sci U S A 106:12301-5. 2009
    ....
  11. doi request reprint Requirement of reactive oxygen species-dependent activation of ASK1-p38 MAPK pathway for extracellular ATP-induced apoptosis in macrophage
    Takuya Noguchi
    Laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, Center of Excellence Program, Japan Science and Technology Corporation, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    J Biol Chem 283:7657-65. 2008
    ..These results demonstrate that ROS-mediated activation of the ASK1-p38 MAPK pathway downstream of P2X(7) receptor is required for ATP-induced apoptosis in macrophages...
  12. doi request reprint A novel monoclonal antibody reveals a conformational alteration shared by amyotrophic lateral sclerosis-linked SOD1 mutants
    Takao Fujisawa
    Laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, Global Center of Education and Research for Chemical Biology of the Diseases, University of Tokyo, Hongo, Tokyo, Japan
    Ann Neurol 72:739-49. 2012
    ..Therefore, it is necessary to develop molecular mechanism-based diagnosis and treatment of ALS caused by SOD1 mutations...
  13. ncbi request reprint The ASK1-MAP kinase cascades in mammalian stress response
    Jun Matsukawa
    Laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, University of Tokyo, and CREST, Japan Science and Technology Corporation, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    J Biochem 136:261-5. 2004
    ..This review summarizes the regulatory mechanisms of ASK1 activity and the physiological roles of ASK1-mediated signal transduction...
  14. ncbi request reprint Apoptosis signal-regulating kinase (ASK) 2 functions as a mitogen-activated protein kinase kinase kinase in a heteromeric complex with ASK1
    Kohsuke Takeda
    Graduate School of Pharmaceutical Sciences, The University of Tokyo, CREST, Japan Science and Technology Corporation, and Strategic Approach to Drug Discovery and Development in Pharmaceutical Sciences, Center of Excellence Program, Japan
    J Biol Chem 282:7522-31. 2007
    ..Such a formation of functional heteromeric complex between different MAP3Ks may be advantageous for cells to cope with a wide variety of stimuli by fine regulation of cellular responses...
  15. pmc ALS-linked mutant SOD1 induces ER stress- and ASK1-dependent motor neuron death by targeting Derlin-1
    Hideki Nishitoh
    Core Research for Evolutional Science and Technology CREST, Japan Science and Technology Corporation, Bunkyo ku, Tokyo 113 0033, Japan
    Genes Dev 22:1451-64. 2008
    ..These findings demonstrate that ER stress-induced ASK1 activation, which is triggered by the specific interaction of Derlin-1 with SOD1(mut), is crucial for disease progression of familial ALS...
  16. pmc ASK1-dependent recruitment and activation of macrophages induce hair growth in skin wounds
    Nao Osaka
    Laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Japan
    J Cell Biol 176:903-9. 2007
    ..These findings indicate that ASK1 is required for wounding-induced infiltration and activation of macrophages, which play central roles in inflammation-dependent hair regrowth in skin...
  17. ncbi request reprint ROS-dependent activation of the TRAF6-ASK1-p38 pathway is selectively required for TLR4-mediated innate immunity
    Atsushi Matsuzawa
    Laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Nat Immunol 6:587-92. 2005
    ..Our data demonstrate that the reactive oxygen species-dependent TRAF6-ASK1-p38 axis is crucial for TLR4-mediated mammalian innate immunity...
  18. doi request reprint p38 MAPKs regulate the expression of genes in the dopamine synthesis pathway through phosphorylation of NR4A nuclear receptors
    Yusuke Sekine
    Global Center of Excellence GCOE Program, and Core Research for Evolutional Science and Technology CREST, Japan Science and Technology Corporation, The University of Tokyo, Japan
    J Cell Sci 124:3006-16. 2011
    ..Thus, p38-regulated gene induction through NR4As appears to function in the dopamine synthesis pathway and may be involved in immune and stress responses...
  19. ncbi request reprint Roles of MAPKKK ASK1 in stress-induced cell death
    Kohsuke Takeda
    Laboratory of Cell Signaling, Graduate School, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8549, Japan
    Cell Struct Funct 28:23-9. 2003
    ..Thus, ASK1 appears to be a pivotal component not only in stress-induced cell death but also in a broad range of biological activities in order for cells to adapt to or oppose various stresses...
  20. doi request reprint Ubiquitin-like sequence in ASK1 plays critical roles in the recognition and stabilization by USP9X and oxidative stress-induced cell death
    Hiroaki Nagai
    Laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, Strategic Approach to Drug Discovery and Development in Pharmaceutical Sciences, Global Center of Excellence Program and Core Research for Evolutional Science and Technology, Japan Science and Technology Corporation, The University of Tokyo, Bunkyo ku, Tokyo 113 0033, Japan
    Mol Cell 36:805-18. 2009
    ..These results demonstrate that USP9X-dependent stabilization of activated ASK1 plays a crucial role in oxidative stress-induced cell death...
  21. pmc CHIP-dependent termination of MEKK2 regulates temporal ERK activation required for proper hyperosmotic response
    Takeshi Maruyama
    Department of Medical Pharmaceutics, Laboratory of Cell Signaling, Japan Science and Technology Corporation, The University of Tokyo, Bunkyo ku, Tokyo, Japan
    EMBO J 29:2501-14. 2010
    ..These findings show that transient activation of the ERK pathway, which depends not only on MEKK2 activation, but also on CHIP-dependent MEKK2 degradation, is crucial for proper gene expression in hyperosmotic stress response...
  22. pmc Involvement of ASK1 in Ca2+-induced p38 MAP kinase activation
    Kohsuke Takeda
    Laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, The University of Tokyo, and CREST, Japan Science and Technology Corporation, Hongo, Tokyo, Japan
    EMBO Rep 5:161-6. 2004
    ..Moreover, p38 activation induced by the expression of constitutively active CaMKII required endogenous ASK1. Thus, ASK1 is a critical intermediate of Ca2+ signalling between CaMKII and p38 MAP kinase...
  23. ncbi request reprint Physiological roles of ASK1-mediated signal transduction in oxidative stress- and endoplasmic reticulum stress-induced apoptosis: advanced findings from ASK1 knockout mice
    Atsushi Matsuzawa
    Laboratory of Cell Signaling, Graduate School, Tokyo Medical and Dental University, 1 5 45, Yushima, Bunkyo ku, Tokyo 113 8549, Japan
    Antioxid Redox Signal 4:415-25. 2002
    ....
  24. ncbi request reprint Recruitment of tumor necrosis factor receptor-associated factor family proteins to apoptosis signal-regulating kinase 1 signalosome is essential for oxidative stress-induced cell death
    Takuya Noguchi
    Laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, The University of Tokyo, CREST, Japan
    J Biol Chem 280:37033-40. 2005
    ..A novel signaling complex including TRAF2, TRAF6, and ASK1 may thus be the key component in oxidative stress-induced cell death...
  25. ncbi request reprint The cytoplasmic domain of Alzheimer's amyloid-beta protein precursor causes sustained apoptosis signal-regulating kinase 1/c-Jun NH2-terminal kinase-mediated neurotoxic signal via dimerization
    Yuichi Hashimoto
    Department of Pharmacology, Keio University School of Medicine, Medical Research Center, Tokyo, Japan
    J Pharmacol Exp Ther 306:889-902. 2003
    ..Understanding the function of AbetaPPCD and its downstream pathway should lead to effective anti-Alzheimer's disease therapeutics...
  26. ncbi request reprint Apoptosis signal-regulating kinase 1 in stress and immune response
    Kohsuke Takeda
    Laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, Japan
    Annu Rev Pharmacol Toxicol 48:199-225. 2008
    ..In this review, we focus on the molecular mechanisms by which ASK1 functions in stress and immune responses and discuss the possible involvement of ASK1 in human diseases...
  27. pmc Prevention of apoptosis by mitochondrial phosphatase PGAM5 in the mushroom body is crucial for heat shock resistance in Drosophila melanogaster
    Yosuke Ishida
    Laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan
    PLoS ONE 7:e30265. 2012
    ..Thus, the MB may possess an apoptosis-dependent toxic function, the suppression of which by dPGAM5 appears to be crucial for HS resistance...
  28. ncbi request reprint The ASK1-MAP kinase pathways in immune and stress responses
    Teruyuki Hayakawa
    Laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Microbes Infect 8:1098-107. 2006
    ..This review is focused on three major subjects on ASK1: the regulatory mechanisms of the kinase activity, the pathophysiological roles in stress response and innate immunity, and the evolutionary perspectives...
  29. doi request reprint Apoptosis signal-regulating kinase 1 inhibits hepatocarcinogenesis by controlling the tumor-suppressing function of stress-activated mitogen-activated protein kinase
    Hayato Nakagawa
    Department of Gastroenterology, University of Tokyo, Tokyo, Japan
    Hepatology 54:185-95. 2011
    ..Similar findings were obtained in tumor necrosis factor alpha-induced hepatocyte apoptosis. Furthermore, ASK1 was involved in DNA damage-induced p21 up-regulation through a p38 pathway...
  30. doi request reprint Deletion of apoptosis signal-regulating kinase 1 attenuates acetaminophen-induced liver injury by inhibiting c-Jun N-terminal kinase activation
    Hayato Nakagawa
    Department of Gastroenterology, University of Tokyo, Hongo, Bunkyo ku, Tokyo
    Gastroenterology 135:1311-21. 2008
    ..We tested the hypothesis that ASK1 was involved in APAP-induced JNK activation and liver injury...
  31. ncbi request reprint Apoptosis signal-regulating kinase 1-mediated signaling pathway regulates hydrogen peroxide-induced apoptosis in human pulmonary vascular endothelial cells
    Tatsuya Machino
    First Department of Internal Medicine, Nihon University School of Medicine, Tokyo, Japan
    Crit Care Med 31:2776-81. 2003
    ..To clarify this issue, we examined the role of ASK1-p38 MAPK/JNK cascade in apoptosis and caspase-3 activation in H2O2-stimulated pulmonary vascular endothelial cells...
  32. doi request reprint Activation mechanisms of ASK1 in response to various stresses and its significance in intracellular signaling
    Shigeru Shiizaki
    Laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Adv Biol Regul 53:135-44. 2013
    ..In this review, we focus on the recent findings on ASK1 and update the regulatory mechanisms of ASK1 activity...
  33. ncbi request reprint Pathophysiological roles of ASK1-MAP kinase signaling pathways
    Hiroaki Nagai
    Laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Japan
    J Biochem Mol Biol 40:1-6. 2007
    ..In this review, we focus on the current findings for the relationship between pathogenesis and ASK1-MAPK pathways...
  34. doi request reprint ASK3 responds to osmotic stress and regulates blood pressure by suppressing WNK1-SPAK/OSR1 signaling in the kidney
    Isao Naguro
    Laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Nat Commun 3:1285. 2012
    ..Our results suggest that ASK3 is a unique bidirectional responder to osmotic stress and that it has a role in the control of blood pressure as an upstream suppressor of the WNK1-SPAK/OSR1 signalling pathway...
  35. doi request reprint Apoptosis signal-regulating kinase 1 is a novel target molecule for cognitive impairment induced by chronic cerebral hypoperfusion
    Kensuke Toyama
    From the Department of Pharmacology and Molecular Therapeutics K T, N K, K U, Y H, K K, T K, D S, M J M, T N, S K M and Department of Cardiovascular Medicine, Faculty of Life Science K T, H O, Kumamoto University Graduate School of Medical Sciences, Kumamoto, Japan Research Fellowship of the Japan Society for the Promotion of Science, Tokyo, Japan K T Department of Cardiovascular Clinical and Translational Research, Kumamoto University Hospital, Kumamoto, Japan O Y Department of Neurology, Graduate School of Medicine, Mie University, Tsu, Japan H T and Laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, and Global Center of Excellence GCOE Program, The University of Tokyo, Tokyo, Japan H I
    Arterioscler Thromb Vasc Biol 34:616-25. 2014
    ..We investigated whether apoptosis signal-regulating kinase 1 (ASK1) might be a key molecule in cerebral hypoperfusion, associated with blood-brain barrier breakdown and white matter lesions...
  36. ncbi request reprint Phosphorylation and inactivation of myeloid cell leukemia 1 by JNK in response to oxidative stress
    Seiji Inoshita
    Laboratory of Cell Signaling, Department of Hard Tissue Engineering, Division of Bio Matrix, Graduate School, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Japan
    J Biol Chem 277:43730-4. 2002
    ..JNK-dependent phosphorylation and thus inactivation of Mcl-1 may be one of the mechanisms through which oxidative stress induces cellular damage...
  37. pmc Rhomboid protease PARL mediates the mitochondrial membrane potential loss-induced cleavage of PGAM5
    Shiori Sekine
    Laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7 3 1 Hongo, Tokyo 113 0033, Japan
    J Biol Chem 287:34635-45. 2012
    ..Our data provide a prototypical example of stress-dependent regulation of PARL-mediated regulated intramembrane proteolysis...
  38. ncbi request reprint GTP binding is essential to the protein kinase activity of LRRK2, a causative gene product for familial Parkinson's disease
    Genta Ito
    Department of Neuropathology and Neuroscience, Graduate School of Pharmaceutical Sciences, University of Tokyo, 7 3 1 Hongo, Bunkyoku, Tokyo, 113 0033 Japan
    Biochemistry 46:1380-8. 2007
    ..These data suggest that binding of GTP to the ROC domain regulates the kinase activity of LRRK2 as well as its phosphorylation by other kinase(s)...
  39. ncbi request reprint Important role of apoptosis signal-regulating kinase 1 in ischemic acute kidney injury
    Yoshio Terada
    Department of Nephrology and Blood Purification, Tokyo Medical and Dental University, 5 45, Yushima 1 chome, Bunkyo ku, Tokyo 113 8519, Japan
    Biochem Biophys Res Commun 364:1043-9. 2007
    ..These results demonstrated that ASK1 is activated in I/R-induced AKI, and blockage of ASK1 attenuates renal tubular apoptosis, MCP-1 expression, and renal function...
  40. doi request reprint Apoptosis signaling kinases: from stress response to health outcomes
    Kohsuke Takeda
    Laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, Strategic Approach to Drug Discovery and Development in Pharmaceutical Sciences, Global Center of Excellence Program and Core Research for Evolutional Science and Technology, Japan Science and Technology Corporation, The University of Tokyo, Tokyo, Japan
    Antioxid Redox Signal 15:719-61. 2011
    ....
  41. doi request reprint The DEAH-box RNA helicase DHX15 activates NF-κB and MAPK signaling downstream of MAVS during antiviral responses
    Kenta Mosallanejad
    1Laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Sci Signal 7:ra40. 2014
    ..Thus, our findings indicate that, in RIG-I-like receptor signaling, DHX15 specifically stimulates the NF-κB and MAPK pathways downstream of MAVS and contributes to MAVS-mediated cytokine production and apoptosis. ..
  42. pmc The Ablation of Mitochondrial Protein Phosphatase Pgam5 Confers Resistance Against Metabolic Stress
    Shiori Sekine
    Laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan
    EBioMedicine 5:82-92. 2016
    ..Our study uncovered that PGAM5 is involved in the whole-body metabolism in response to stresses that impose metabolic challenges on mitochondria. ..
  43. pmc ASK1 signalling regulates brown and beige adipocyte function
    Kazuki Hattori
    The laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Nat Commun 7:11158. 2016
    ..Our data thus indicate that the ASK1 signalling axis is a regulator of brown and beige adipocyte gene expression and function. ..
  44. pmc Osmotic stress induces the phosphorylation of WNK4 Ser575 via the p38MAPK-MK pathway
    Junichi Maruyama
    Laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Sci Rep 6:18710. 2016
    ..Our results suggest that the p38MAPK-MK pathway might regulate WNK4 in an osmotic stress-dependent manner but its upstream regulators might be divergent depending on the types of osmotic stimuli. ..
  45. doi request reprint A systematic immunoprecipitation approach reinforces the concept of common conformational alterations in amyotrophic lateral sclerosis-linked SOD1 mutants
    Takao Fujisawa
    Laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Neurobiol Dis 82:478-86. 2015
    ..Moreover, all pathogenic SOD1(mut), without exception, were immunoprecipitated with a combination of MS785 and MS27. The MS785-MS27 combination could be developed as a novel mechanism-based biomarker for the diagnosis of ALS. ..
  46. pmc Apoptosis Signal-regulating Kinase 1 (ASK1)-p38 Pathway-dependent Cytoplasmic Translocation of the Orphan Nuclear Receptor NR4A2 Is Required for Oxidative Stress-induced Necrosis
    Takeshi Watanabe
    From the Laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan, the Department of Cellular Physiological Chemistry, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Yushima, 1 5 45 Bunkyo Ku, Tokyo 113 8510, Japan, and
    J Biol Chem 290:10791-803. 2015
    ..Our findings may enable a more precise understanding of molecular mechanisms that regulate oxidative stress-induced and p38-mediated necrosis. ..
  47. ncbi request reprint Identification of Op18/stathmin as a potential target of ASK1-p38 MAP kinase cascade
    Kenji Mizumura
    Laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, The University of Tokyo, and CREST, Japan Science and Technology Corporation, Tokyo, Japan
    J Cell Physiol 206:363-70. 2006
    ..Given that the microtubule-destabilizing activity of Op18/stathmin is regulated by its phosphorylation, the ASK1-p38 cascade may regulate microtubule dynamics through Op18/stathmin...
  48. ncbi request reprint Stress-responsive protein kinases in redox-regulated apoptosis signaling
    Atsushi Matsuzawa
    Laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Antioxid Redox Signal 7:472-81. 2005
    ..It also provides recent findings on the molecular mechanisms by which redox signaling cross-talks with stress-responsive protein kinase cascades...
  49. pmc Release of RASSF1C from the nucleus by Daxx degradation links DNA damage and SAPK/JNK activation
    Daiju Kitagawa
    The Department of Developmental and Regenerative Biology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan
    EMBO J 25:3286-97. 2006
    ..Our data define a novel mechanism by which the Daxx-RASSF1C complex in PML-NBs couples nuclear DNA damage to the cytoplasmic SAPK/JNK signaling pathway...
  50. ncbi request reprint ASK family proteins in stress response and disease
    Takao Fujisawa
    Laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, 113 0033, Japan
    Mol Biotechnol 37:13-8. 2007
    ..Here, we highlight the roles of members of the ASK family, which consists of ASK1 and newly characterized ASK2, in ROS signaling with their possible involvement in human diseases...
  51. doi request reprint Regulation of apoptosis signal-regulating kinase 1 in redox signaling
    Kazumi Katagiri
    Laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Hongo, Bunkyo ku, Tokyo, Japan
    Methods Enzymol 474:277-88. 2010
    ..The techniques presented in this chapter will be useful for a range of investigations into intracellular redox signaling...
  52. doi request reprint Hyperactivity in novel environment with increased dopamine and impaired novelty preference in apoptosis signal-regulating kinase 1 (ASK1)-deficient mice
    Karen Kumakura
    Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Bunkyo ku, Tokyo, Japan
    Neurosci Res 66:313-20. 2010
    ..Our findings thus demonstrate novel behavioral functions of ASK1, including regulation of locomotor activity, novelty preference, and motor coordination with dopaminergic transmission...
  53. doi request reprint Roquin-2 promotes ubiquitin-mediated degradation of ASK1 to regulate stress responses
    Takeshi Maruyama
    1Laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Sci Signal 7:ra8. 2014
    ..Thus, these data suggest that degradation of ASK1 mediated by Roquin-2 is an evolutionarily conserved mechanism required for the appropriate regulation of stress responses, including pathogen resistance and cell death. ..
  54. ncbi request reprint Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system
    Kohsuke Takeda
    Laboratory of Cell Signalling, Graduate School, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Japan
    Genes Cells 7:1099-111. 2002
    ..This review focuses on possible roles for the p38 pathway in the nervous system, with principal emphasis placed on the roles in neuronal cell fate decision and function...
  55. pmc Regulation of anoxic death in Caenorhabditis elegans by mammalian apoptosis signal-regulating kinase (ASK) family proteins
    Teruyuki Hayakawa
    Laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, Strategic Approach to Drug Discovery and Development in Pharmaceutical Sciences, Global Center of Excellence Program, The University of Tokyo, 7 3 1 Hongo, Tokyo 113 0033, Japan
    Genetics 187:785-92. 2011
    ..These results suggest that the TIR-1-NSY-1-SEK-1-PMK-1 pathway plays important roles in the reponse to anoxia in C. elegans...
  56. pmc Therapeutic targets in the ASK1-dependent stress signaling pathways
    Ryoichi Hayakawa
    Laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan
    Proc Jpn Acad Ser B Phys Biol Sci 88:434-53. 2012
    ..In this review, we provide an overview of the pathophysiological roles of ASK1-dependent signaling pathways and discuss the mechanistic basis for how these could serve as potential therapeutic targets...
  57. ncbi request reprint Stress-activated MAP kinase cascades in cellular senescence
    Junichi Maruyama
    Laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Curr Med Chem 16:1229-35. 2009
    ..In this review, we focus on signaling that regulates stress-induced cellular senescence, with special focus on the JNK and p38 MAPK cascades...
  58. ncbi request reprint Role of Rho in rabbit parietal cell
    Keiichiro Tashiro
    Laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo
    J Cell Physiol 197:409-17. 2003
    ....
  59. ncbi request reprint Thioredoxin and protein kinases in redox signaling
    Go Fujino
    Laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, The University of Tokyo, CREST, Japan Science and Technology Corporation, and Strategic Approach to Drug Discovery and Development in Pharmaceutical Sciences, Tokyo, Japan
    Semin Cancer Biol 16:427-35. 2006
    ..Understanding of such mechanisms may provide the basis for therapeutic interventions in redox-related diseases including various types of cancer...
  60. ncbi request reprint Activation of apoptosis signal-regulating kinase 1 by the stress-induced activating phosphorylation of pre-formed oligomer
    Kei Tobiume
    Laboratory of Cell Signaling, Graduate School, Tokyo Medical and Dental University, Bunkyo ku, Tokyo, Japan
    J Cell Physiol 191:95-104. 2002
    ..We propose that this potential Thr845 kinase may be an ignition kinase that triggers Thr845 phosphorylation in oligomerized and activation-competent forms of ASK1...
  61. pmc KLHDC10 Deficiency Protects Mice against TNFα-Induced Systemic Inflammation
    Namiko Yamaguchi
    Laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan
    PLoS ONE 11:e0163118. 2016
    ..Our results suggest that KLHDC10 is a cell-type specific regulator of necroptosis that ultimately contributes to the development of TNFα-induced SIRS. ..
  62. doi request reprint The ASK family kinases differentially mediate induction of type I interferon and apoptosis during the antiviral response
    Tomohiko Okazaki
    Laboratory of Molecular Biology, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo 113 0033, Japan
    Sci Signal 8:ra78. 2015
    ..Because ASK2 is selectively present in epithelium-rich tissues, such as the lung, ASK2-dependent apoptosis may contribute to an antiviral defense in tissues with a rapid repair rate in which cells could be readily replaced. ..
  63. doi request reprint The ASK1-specific inhibitors K811 and K812 prolong survival in a mouse model of amyotrophic lateral sclerosis
    Takao Fujisawa
    Laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Hum Mol Genet 25:245-53. 2016
    ..These results reinforce the importance of ASK1 as a therapeutic target for ALS treatment. ..
  64. ncbi request reprint Survival and apoptosis signals in ER stress: the role of protein kinases
    Hisae Kadowaki
    Cell Signaling, Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    J Chem Neuroanat 28:93-100. 2004
    ..The main purpose of this review is to summarize current knowledge about the protein kinases involved in ER stress, and their involvement in the pathogenesis of neurodegenerative disorders...
  65. pmc ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeats
    Hideki Nishitoh
    Laboratory of Cell Signaling, Graduate School, Tokyo Medical and Dental University, Bunkyo ku 113 8549, Japan
    Genes Dev 16:1345-55. 2002
    ..These findings suggest that ASK1 is a key element in ER stress-induced cell death that plays an important role in the neuropathological alterations in polyQ diseases...
  66. doi request reprint Requirement of apoptosis-inducing kinase 1 for the induction of bronchial asthma following stimulation with ovalbumin
    Eiko Takada
    Department of Immunology, Tokyo Medical University, Tokyo, Japan
    Int Arch Allergy Immunol 162:104-14. 2013
    ....
  67. doi request reprint Targeting ASK1 in ER stress-related neurodegenerative diseases
    Kengo Homma
    The University of Tokyo, Graduate School of Pharmaceutical Sciences, Cell Signaling, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Expert Opin Ther Targets 13:653-64. 2009
    ..In this review, we summarize the molecular mechanisms of the UPR and ER stress-induced apoptosis and the possible roles of ASK1 activation in neurodegenerative diseases...
  68. doi request reprint Redox control of cell fate by MAP kinase: physiological roles of ASK1-MAP kinase pathway in stress signaling
    Atsushi Matsuzawa
    Laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo 113 0033, Japan
    Biochim Biophys Acta 1780:1325-36. 2008
    ..In this review, we focus on redox control of cell function by MAP kinase signaling, and provide the advanced mechanism of redox-regulated ASK1 activation and physiological roles of the ASK1-MAP kinase pathway in stress signaling...
  69. ncbi request reprint The ASK1-MAP kinase signaling in ER stress and neurodegenerative diseases
    Yusuke Sekine
    Laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Japan
    Curr Mol Med 6:87-97. 2006
    ..This review highlights the current understanding of regulatory mechanisms of ASK1 with a special focus on the ER stress-dependent and -independent neuronal cell death in the context of neurodegenerative diseases...
  70. ncbi request reprint [Regulatiory mechanism of cell dealth through ASK1]
    yoshiko Komuro
    Laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, University of Tokyo, Japan
    Seikagaku 76:1458-62. 2004
  71. ncbi request reprint Stress signaling in cancer
    Shiori Murakami
    Laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, The University of Tokyo, CREST, Japan Science and Technology Corporation, Bunkyo ku, Tokyo 113 0033, Japan
    Cancer Sci 98:1521-7. 2007
    ..In the present review, the authors focus on the current understanding of the critical linkage between stress signaling and cancer...
  72. pmc L-type Ca2+ channels serve as a sensor of the SR Ca2+ for tuning the efficacy of Ca2+-induced Ca2+ release in rat ventricular myocytes
    Hajime Takamatsu
    Laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    J Physiol 552:415-24. 2003
    ....
  73. ncbi request reprint [Novel roles of stress kinases: focusing on the ASK family]
    Kohsuke Takeda
    Tanpakushitsu Kakusan Koso 53:1246-51. 2008
  74. ncbi request reprint [Molecular mechanisms of ER stress-induced apoptosis]
    Hideki Nishitoh
    Tanpakushitsu Kakusan Koso 49:1006-9. 2004
  75. doi request reprint Pre-emptive Quality Control Protects the ER from Protein Overload via the Proximity of ERAD Components and SRP
    Hisae Kadowaki
    Laboratory of Biochemistry and Molecular Biology, Department of Medical Sciences, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki 889 1692, Japan Laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan Center of Excellence Program, Tokyo Medical and Dental University, Bunkyo ku, Tokyo 113 8510, Japan
    Cell Rep 13:944-56. 2015
    ..These findings demonstrate that Derlins-mediated substrate-specific rerouting and Bag6- and p97-mediated effective degradation contribute to the maintenance of ER homeostasis without the need for translocation...
  76. pmc ASK1 promotes the contact hypersensitivity response through IL-17 production
    Junya Mizukami
    1 Laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, Japan, 113 0033 2 Department of Dermatology, Tokyo Medical University, 6 7 1 Nishishinjuku, Shinjuku ku, Tokyo, Japan, 160 0023
    Sci Rep 4:4714. 2014
    ..These results suggest that ASK1 is relevant to the overall CHS response during the elicitation phase and that ASK1 may be a promising therapeutic target for allergic contact dermatitis and other IL-17-related inflammatory diseases. ..
  77. pmc The lysosome rupture-activated TAK1-JNK pathway regulates NLRP3 inflammasome activation
    Masahiro Okada
    From the Laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan, The Department of Microbiology and Immunology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan, and
    J Biol Chem 289:32926-36. 2014
    ..These data suggest a novel role for the TAK1-JNK pathway as a critical regulator of NLRP3 inflammasome activation. ..
  78. doi request reprint Apoptosis signal-regulating kinase-1 inhibitor as a potent therapeutic drug for the treatment of gastric cancer
    Yoku Hayakawa
    Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Cancer Sci 103:2181-5. 2012
    ..These results indicate that ASK1 inhibition prevents GC cell growth in vitro and in vivo, suggesting that ASK1 inhibitors can be potent therapeutic drugs for GC...
  79. ncbi request reprint Key roles of Phe1112 and Ser1115 in the pore-forming IIIS5-S6 linker of L-type Ca2+ channel alpha1C subunit (CaV 1.2) in binding of dihydropyridines and action of Ca2+ channel agonists
    Shinji Yamaguchi
    Laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Mol Pharmacol 64:235-48. 2003
    ..A model of the DHP receptor is proposed to visualize possible interactions of Phe1112, Ser1115, and other DHP-sensing residues with a typical DHP ligand nifedipine...
  80. doi request reprint Mitogen-activated protein kinases in mammalian oxidative stress responses
    Christopher Runchel
    Laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Japan
    Antioxid Redox Signal 15:205-18. 2011
    ..In this review, we will discuss the physiological roles of MAPKs in oxidative stress, the upstream signaling pathways leading to MAPK activation, their regulation, and the MAPK downstream substrates, with a focus on mammalian systems...
  81. ncbi request reprint Phosphorylation-dependent scaffolding role of JSAP1/JIP3 in the ASK1-JNK signaling pathway. A new mode of regulation of the MAP kinase cascade
    Hiroshi Matsuura
    Laboratory of Cell Signaling, Graduate School, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8549, Japan
    J Biol Chem 277:40703-9. 2002
    ..We thus conclude that JSAP1 functions not only as a simple scaffold, but it dynamically participates in signal transduction by forming a phosphorylation-dependent signaling complex in the ASK1-JNK signaling module...
  82. ncbi request reprint Role of ADP-ribosylation factor 6 (ARF6) in gastric acid secretion
    Jun Matsukawa
    Laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo 113 0033, Japan
    J Biol Chem 278:36470-5. 2003
    ..These results suggest that ARF6 regulates gastric acid secretion in parietal cell and that the GTP hydrolysis cycle of ARF6 is essential for the activation pathway...
  83. pmc The phosphorylation-dependent regulation of mitochondrial proteins in stress responses
    Yusuke Kanamaru
    Laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    J Signal Transduct 2012:931215. 2012
    ..In this paper, we focus on the phosphorylation-dependent regulation of mitochondrial proteins and discuss the roles of this regulation in the mitochondrial and cellular stress responses...
  84. ncbi request reprint Involvement of apoptosis signal-regulating kinase-1 on angiotensin II-induced monocyte chemoattractant protein-1 expression
    Takashi Omura
    Department of Internal Medicine and Cardiology, Osaka City University Medical School, 1 4 3 Asahimachi, Abeno Ku, Osaka 545 8585, Japan
    Arterioscler Thromb Vasc Biol 24:270-5. 2004
    ..To elucidate these molecular mechanisms, angiotensin II-induced expression of MCP-1 was examined in cultured rat neonatal ventricular cardiomyocytes and fibroblasts by adenovirus gene transfer...
  85. ncbi request reprint Activation of apoptosis signal-regulating kinase 1 in injured artery and its critical role in neointimal hyperplasia
    Yasukatsu Izumi
    Department of Pharmacology, Osaka City University Graduate School of Medicine, 1 4 3 Asahimachi, Abeno, Osaka 545 8585, Japan
    Circulation 108:2812-8. 2003
    ..Therefore, we first examined the role of ASK1 in vascular remodeling...
  86. ncbi request reprint Reaper-mediated inhibition of DIAP1-induced DTRAF1 degradation results in activation of JNK in Drosophila
    Erina Kuranaga
    Laboratory for Cell Recovery Mechanisms, RIKEN Brain Science Institute, 2 1 Hirosawa, Wako, Saitama 351 0198, Japan
    Nat Cell Biol 4:705-10. 2002
    ..Taken together, our results indicate that DIAP1 may modulate cell death by regulating JNK activation through a ubiquitin#150;proteasome pathway...
  87. pmc Oxidation-triggered c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein (MAP) kinase pathways for apoptosis in human leukaemic cells stimulated by epigallocatechin-3-gallate (EGCG): a distinct pathway from those of chemically induced and recep
    Koichi Saeki
    Department of Haematology, Research Institute, International Medical Centre of Japan, 1 21 1, Toyama, Shinjuku ku, Tokyo 162 8655, Japan
    Biochem J 368:705-20. 2002
    ....
  88. ncbi request reprint Liver protection from apoptosis requires both blockage of initiator caspase activities and inhibition of ASK1/JNK pathway via glutathione S-transferase regulation
    David Gilot
    INSERM U522, Régulation des équilibres fonctionnels du foie normal et pathologique, Avenue de la Bataille Flandre Dunkerque, Hopital Pontchaillou, 35033 Rennes, France
    J Biol Chem 277:49220-9. 2002
    ..Furthermore, in highlighting the control of apoptosis by GSTs, these data provide new insights for analyzing the complex mechanisms of hepatoprotection...
  89. ncbi request reprint Apoptosis signal-regulating kinase 1 plays a pivotal role in angiotensin II-induced cardiac hypertrophy and remodeling
    Yasuhiro Izumiya
    Department of Pharmacology, Osaka City University Graduate School of Medical Science, 1 4 3 Asahimachi, Abeno, Osaka 545 8585, Japan
    Circ Res 93:874-83. 2003
    ..These results provided the first in vivo evidence that ASK1 is the critical signaling molecule for Ang II-induced cardiac hypertrophy and remodeling. Thus, ASK1 is proposed to be a potential therapeutic target for cardiac diseases...
  90. ncbi request reprint ASK1 regulates influenza virus infection-induced apoptotic cell death
    Shuichiro Maruoka
    First Department of Internal Medicine, Nihon University School of Medicine, 30 1 Oyaguchikamimachi, Itabashi ku, Tokyo 173 8610, Japan
    Biochem Biophys Res Commun 307:870-6. 2003
    ..These results indicate that apoptosis in IV-infected BEC is mediated through ASK1-dependent cascades...
  91. ncbi request reprint Type 1 insulin-like growth factor receptor (IGF-IR) signaling inhibits apoptosis signal-regulating kinase 1 (ASK1)
    Veronica Galvan
    Buck Institute for Age Research, Novato, California 94945 1400, USA
    J Biol Chem 278:13325-32. 2003
    ....
  92. ncbi request reprint Apoptosis signal-regulating kinase 1-mediated signaling pathway regulates nitric oxide-induced activator protein-1 activation in human bronchial epithelial cells
    Itsuro Jibiki
    First Department of Internal Medicine, Nihon University School of Medicine, 30 1 Oyaguchikamimachi, Itabashi ku, Tokyo 173 8610, Japan
    Am J Respir Crit Care Med 167:856-61. 2003
    ..These results indicate that NO is capable of inducing AP-1 activation, and that ASK1-p38 MAPK/JNK cascade regulates AP-1 activation in NO-stimulated BEC...
  93. ncbi request reprint Sustained activation of the JNK cascade and rapamycin-induced apoptosis are suppressed by p53/p21(Cip1)
    Shile Huang
    Department of Molecular Pharmacology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Mol Cell 11:1491-501. 2003
    ..These results suggest that inhibition of mTOR triggers a potentially lethal response that is prevented only in cells expressing p21(Cip1)...
  94. ncbi request reprint Apoptosis-signal regulating kinase-1 is involved in the low potassium-induced activation of p38 mitogen-activated protein kinase and c-Jun in cultured cerebellar granule neurons
    Satoru Yamagishi
    Division of Protein Biosynthesis, Institute for Protein Research, Osaka University, Suita, Osaka
    J Biochem 133:719-24. 2003
    ..The addition of LY294002, a specific inhibitor of PI3-K, enhanced the ASK1 activity. These results indicate that ASK1 works downstream of PI3-K to regulate the p38-c-Jun pathway and apoptosis in cultured cerebellar granule neurons...
  95. ncbi request reprint Interaction of apoptosis signal-regulating kinase 1 with isoforms of 14-3-3 proteins
    Romesh R Subramanian
    Department of Pharmacology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Exp Cell Res 294:581-91. 2004
    ..These data support a model that 14-3-3 proteins regulate the proapoptotic function of ASK1 in part by controlling its subcellular distribution...
  96. ncbi request reprint Chk2 kinase is required for methylglyoxal-induced G2/M cell-cycle checkpoint arrest: implication of cell-cycle checkpoint regulation in diabetic oxidative stress signaling
    Shuichi Kani
    Department of Physiology and Cell Biology, Faculty of Medical Sciences, Graduate School of Medicine, Kobe University, 7 5 1, Kusunoki cho, Chuo Ku, Kobe 650 0017, Japan
    Genes Cells 12:919-28. 2007
    ..Thus, the results indicate a critical role for Chk2 in MG-induced G(2)/M cell-cycle checkpoint arrest...
  97. pmc Role of apoptosis signal-regulating kinase 1 in stress-induced neural cell apoptosis in vivo
    Chikako Harada
    Department of Molecular Neurobiology, Tokyo Metropolitan Institute for Neuroscience, 2 6 Musashidai, Fuchu, Tokyo 183 8526, Japan
    Am J Pathol 168:261-9. 2006
    ..Our findings suggest that ASK1 is involved in the neural cell apoptosis after various kinds of oxidative stress. Thus, inhibition of the ASK1-p38 pathway could be useful for the treatment of neurodegenerative diseases including glaucoma...
  98. pmc Targeted deletion of apoptosis signal-regulating kinase 1 attenuates left ventricular remodeling
    Osamu Yamaguchi
    Departments of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, Osaka 565 0871, Japan
    Proc Natl Acad Sci U S A 100:15883-8. 2003
    ..An in vitro kinase assay showed increased ASK1 activity in heart after MI or TAC in WT mice. Thus, ASK1 plays an important role in regulating left ventricular remodeling by promoting apoptosis...
  99. ncbi request reprint Role of c-Jun NH2-terminal kinase in G-protein-coupled receptor agonist-induced cardiac plasminogen activator inhibitor-1 expression
    Takashi Omura
    Department of Internal Medicine and Cardiology, Osaka City University Medical School, 1 4 3 Asahi machi, Abeno Ku, Osaka 545 8585, Japan
    J Mol Cell Cardiol 38:583-92. 2005
    ..In conclusion, G-protein-coupled receptor agonist-induced PAI-1 expression is partially mediated through JNK activation...
  100. pmc Cardiac-specific disruption of the c-raf-1 gene induces cardiac dysfunction and apoptosis
    Osamu Yamaguchi
    Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    J Clin Invest 114:937-43. 2004
    ..The ablation of ASK1 rescued heart dysfunction and dilatation as well as cardiac fibrosis. These results indicate that Raf-1 promotes cardiomyocyte survival through a MEK/ERK-independent mechanism...
  101. ncbi request reprint Inhibition of mammalian target of rapamycin activates apoptosis signal-regulating kinase 1 signaling by suppressing protein phosphatase 5 activity
    Shile Huang
    Department of Molecular Pharmacology, St Jude Children s Research Hospital, 332 Lauderdale, Memphis, TN 38105 2794, USA
    J Biol Chem 279:36490-6. 2004
    ..The findings suggest that in the absence of serum factors, mTOR signaling suppresses apoptosis through positive regulation of PP5 activity and suppression of cellular stress...