Yuko Ibuki

Summary

Affiliation: University of Shizuoka
Country: Japan

Publications

  1. doi request reprint γ-H2AX is a sensitive marker of DNA damage induced by metabolically activated 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone
    Yuko Ibuki
    Graduate Division of Nutritional and Environmental Sciences, University of Shizuoka, Shizuoka, Japan Electronic address
    Toxicol In Vitro 29:1831-8. 2015
  2. pmc Evaluation of chemical phototoxicity, focusing on phosphorylated histone H2AX
    Yuko Ibuki
    Graduate Division of Nutritional and Environmental Sciences, University of Shizuoka, Shizuoka, Japan
    J Radiat Res 56:220-8. 2015
  3. doi request reprint Cigarette sidestream smoke induces histone H3 phosphorylation via JNK and PI3K/Akt pathways, leading to the expression of proto-oncogenes
    Yuko Ibuki
    Institute for Environmental Sciences, University of Shizuoka, Yada 52 1, Suruga ku, Shizuoka 422 8526, Japan
    Carcinogenesis 35:1228-37. 2014
  4. doi request reprint Nanoparticle uptake measured by flow cytometry
    Yuko Ibuki
    Institute for Environmental Sciences, University of Shizuoka, Shizuoka shi, Japan
    Methods Mol Biol 926:157-66. 2012
  5. ncbi request reprint Hydrogen peroxide is critical for UV-induced apoptosis inhibition
    Yuko Ibuki
    Laboratory of Radiation Biology, Graduate School of Nutritional and Environmental Sciences, University of Shizuoka, Shizuoka, Japan
    Redox Rep 11:53-60. 2006
  6. ncbi request reprint Inhibition of apoptosis by menadione on exposure to UVA
    Y Ibuki
    Laboratory of Radiation Biology, Graduate School of Nutritional and Environmental Sciences, University of Shizuoka, 52 1, Yada, Shizuoka shi, 422 8526, Japan
    Cell Biol Toxicol 22:351-60. 2006
  7. ncbi request reprint Water soluble fraction of solar-simulated light-exposed crude oil generates phosphorylation of histone H2AX in human skin cells under UVA exposure
    Yuko Ibuki
    Laboratory of Radiation Biology, Graduate School of Nutritional and Environmental Sciences, University of Shizuoka, Shizuoka shi 422 8526, Japan
    Environ Mol Mutagen 48:430-9. 2007
  8. doi request reprint UVB-exposed chlorinated bisphenol A generates phosphorylated histone H2AX in human skin cells
    Yuko Ibuki
    Laboratory of Radiation Biology, Graduate School of Nutritional and Environmental Sciences, Institute for Environmental Sciences, University of Shizuoka, Shizuoka shi 422 8526, Japan
    Chem Res Toxicol 21:1770-6. 2008
  9. doi request reprint Akt1-mediated intracellular oxidation after UVB irradiation suppresses apoptotic cell death induced by cell detachment and serum starvation
    Yuko Ibuki
    Laboratory of Radiation Biology, Graduate School of Nutritional and Environmental Sciences, University of Shizuoka, Shizuoka shi, Japan
    Photochem Photobiol 84:154-61. 2008
  10. doi request reprint UVB irradiation changes genotoxic potential of nonylphenolpolyethoxylates--remarkable generation of γ-H2AX with degradation of chemical structure
    Tatsushi Toyooka
    Institute for Environmental Sciences, University of Shizuoka, 52 1 Yada, Suruga ku, Shizuoka shi, Shizuoka 422 8526, Japan
    Mutagenesis 28:7-14. 2013

Collaborators

Detail Information

Publications57

  1. doi request reprint γ-H2AX is a sensitive marker of DNA damage induced by metabolically activated 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone
    Yuko Ibuki
    Graduate Division of Nutritional and Environmental Sciences, University of Shizuoka, Shizuoka, Japan Electronic address
    Toxicol In Vitro 29:1831-8. 2015
    ..These findings suggest that γ-H2AX is a sensitive marker of DNA adducts and provides a possible system for genotoxicity screening of chemicals such as NNK, which need metabolic activation to induce DNA damage. ..
  2. pmc Evaluation of chemical phototoxicity, focusing on phosphorylated histone H2AX
    Yuko Ibuki
    Graduate Division of Nutritional and Environmental Sciences, University of Shizuoka, Shizuoka, Japan
    J Radiat Res 56:220-8. 2015
    ..In this review, we introduced our recent findings concerning the evaluation of chemical phototoxicity, focusing on γ-H2AX. ..
  3. doi request reprint Cigarette sidestream smoke induces histone H3 phosphorylation via JNK and PI3K/Akt pathways, leading to the expression of proto-oncogenes
    Yuko Ibuki
    Institute for Environmental Sciences, University of Shizuoka, Yada 52 1, Suruga ku, Shizuoka 422 8526, Japan
    Carcinogenesis 35:1228-37. 2014
    ..These findings suggested that any chemicals in CSS, including aldehydes, phosphorylate H3S10 via JNK and PI3K/Akt pathways, which is different from the DNA damage response, resulting in tumor promotion...
  4. doi request reprint Nanoparticle uptake measured by flow cytometry
    Yuko Ibuki
    Institute for Environmental Sciences, University of Shizuoka, Shizuoka shi, Japan
    Methods Mol Biol 926:157-66. 2012
    ..We recently clarified that the side-scatter(ed) light of FCM could be used as a guide to measure uptake potential of nanoparticles. Here, we describe the protocol for screening of the uptake potential of nanoparticles using FCM...
  5. ncbi request reprint Hydrogen peroxide is critical for UV-induced apoptosis inhibition
    Yuko Ibuki
    Laboratory of Radiation Biology, Graduate School of Nutritional and Environmental Sciences, University of Shizuoka, Shizuoka, Japan
    Redox Rep 11:53-60. 2006
    ..These findings suggested that H2O2 was essential to the inhibition of apoptosis, in which DNA damage had no role...
  6. ncbi request reprint Inhibition of apoptosis by menadione on exposure to UVA
    Y Ibuki
    Laboratory of Radiation Biology, Graduate School of Nutritional and Environmental Sciences, University of Shizuoka, 52 1, Yada, Shizuoka shi, 422 8526, Japan
    Cell Biol Toxicol 22:351-60. 2006
    ..Dysregulation of the apoptotic process is critical to carcinogenesis. The photosensitization of quinone compounds as it relates to the inhibition of apoptosis should be examined in the future...
  7. ncbi request reprint Water soluble fraction of solar-simulated light-exposed crude oil generates phosphorylation of histone H2AX in human skin cells under UVA exposure
    Yuko Ibuki
    Laboratory of Radiation Biology, Graduate School of Nutritional and Environmental Sciences, University of Shizuoka, Shizuoka shi 422 8526, Japan
    Environ Mol Mutagen 48:430-9. 2007
    ..These findings demonstrate that exposure of crude oil to sunlight makes the WSF phototoxic, generating DSBs accompanying the appearance of gamma-H2AX in human skin cells...
  8. doi request reprint UVB-exposed chlorinated bisphenol A generates phosphorylated histone H2AX in human skin cells
    Yuko Ibuki
    Laboratory of Radiation Biology, Graduate School of Nutritional and Environmental Sciences, Institute for Environmental Sciences, University of Shizuoka, Shizuoka shi 422 8526, Japan
    Chem Res Toxicol 21:1770-6. 2008
    ..Considering that the phosphorylation of histone H2AX is required for maintaining the genome's stability and the repair of DNA, attention to photoproducts from chlorinated compounds is important for the risk evaluation of chemicals...
  9. doi request reprint Akt1-mediated intracellular oxidation after UVB irradiation suppresses apoptotic cell death induced by cell detachment and serum starvation
    Yuko Ibuki
    Laboratory of Radiation Biology, Graduate School of Nutritional and Environmental Sciences, University of Shizuoka, Shizuoka shi, Japan
    Photochem Photobiol 84:154-61. 2008
    ..These findings suggest that appropriate intracellular oxidation after UVB irradiation prevented apoptosis, a process which might be partially regulated by the production of reactive oxygen species mediated by Akt1...
  10. doi request reprint UVB irradiation changes genotoxic potential of nonylphenolpolyethoxylates--remarkable generation of γ-H2AX with degradation of chemical structure
    Tatsushi Toyooka
    Institute for Environmental Sciences, University of Shizuoka, 52 1 Yada, Suruga ku, Shizuoka shi, Shizuoka 422 8526, Japan
    Mutagenesis 28:7-14. 2013
    ..This study suggests the importance of taking the genotoxicity of photodegraded intermediates into consideration when conducting risk assessments of environmental pollutants...
  11. doi request reprint Titanium dioxide particles phosphorylate histone H2AX independent of ROS production
    Tatsushi Toyooka
    University of Shizuoka, Yada, Suruga ku, Shizuoka, Japan
    Mutat Res 742:84-91. 2012
    ..These results suggested that smaller TiO(2) particles were easy to incorporate into cells and generated cell cycle phase-independent γ-H2AX, which was dependent on the condition of the TiO(2) surface but not on the formation of ROS...
  12. doi request reprint Generation of phosphorylated histone H2AX by benzene metabolites
    Mio Ishihama
    Laboratory of Radiation Biology, Graduate School of Nutritional and Environmental Sciences, University of Shizuoka, 52 1 Yada, Shizuoka shi 422 8526, Japan
    Toxicol In Vitro 22:1861-8. 2008
    ..DSBs are the most serious form of DNA damage and are associated with genomic instability leading to myeloid leukemia. gamma-H2AX may be a useful tool for judging the genotoxicity of benzene metabolites sensitively...
  13. doi request reprint Preparation of DNA-adsorbed TiO2 particles--augmentation of performance for environmental purification by increasing DNA adsorption by external pH regulation
    Takeharu Amano
    Laboratory of Radiation Biology, Institute for Environmental Sciences, Graduate School of Nutritional and Environmental Sciences, University of Shizuoka, 52 1 Yada, Shizuoka shi 422 8526, Japan
    Sci Total Environ 408:480-5. 2010
    ..These results indicated that preparation of DNA-TiO(2) at pH2 has advantages in that much DNA can be attached and large amounts of chemicals can be concentrated in the DNA, resulting in extensive decomposition under UV light...
  14. doi request reprint Flow cytometric evaluation of nanoparticles using side-scattered light and reactive oxygen species-mediated fluorescence-correlation with genotoxicity
    Yousuke Toduka
    Institute for Environmental Sciences, University of Shizuoka, 52 1 Yada, Suruga ku, Shizuoka shi, Shizuoka 422 8526, Japan
    Environ Sci Technol 46:7629-36. 2012
    ..This method makes it possible to predict not only uptake potential but also genotoxicity...
  15. doi request reprint Induction of apoptosis by UV-irradiated chlorinated bisphenol A in Jurkat cells
    Yasuko Mutou
    Laboratory of Radiation Biology, Graduate School of Nutritional and Environmental Sciences, University of Shizuoka, 52 1 Yada, Shizuoka shi 422 8526, Japan
    Toxicol In Vitro 22:864-72. 2008
    ..In addition, 3-OHBPA induced apoptosis similar to UVB- or UVC-irradiated ClBPA. These results suggested that the photoproducts of ClBPAs generated by UV irradiation, containing 3-OHBPA, contributed to the induction of apoptosis...
  16. doi request reprint UVB in solar-simulated light causes formation of BaP-photoproducts capable of generating phosphorylated histone H2AX
    Go Ohnuki
    Laboratory of Radiation Biology, Graduate School of Nutritional and Environmental Sciences, University of Shizuoka, Yada, Shizuoka shi, Japan
    Mutat Res 702:70-7. 2010
    ..UVB is a two-edged blade in environments, effectively degrading toxic chemicals but also producing genotoxic compounds as reactive intermediates...
  17. doi request reprint Nonylphenol polyethoxylates degraded by three different wavelengths of UV and their genotoxic change--detected by generation of γ-H2AX
    Toru Kubota
    Institute for Environmental Sciences, University of Shizuoka, Shizuoka shi, Shizuoka, Japan
    Photochem Photobiol 89:461-7. 2013
    ..These results suggested that UV rays can make NPEOs harmless or genotoxic according to the degradation of the EO side chain, the effects being dependent on wavelength...
  18. ncbi request reprint Solar-simulated light-exposed benzo[a]pyrene induces phosphorylation of histone H2AX
    Tatsushi Toyooka
    Laboratory of Radiation Biology, Graduate School of Nutritional and Environmental Sciences, University of Shizuoka, Shizuoka shi, Japan
    Mutat Res 650:132-9. 2008
    ..The appearance of gamma-H2AX means the induction of the most serious form of DNA damage, DSBs, suggesting the potential risk of carcinogenesis...
  19. ncbi request reprint Preparation of DNA-adsorbed TiO2 particles with high performance for purification of chemical pollutants
    Hiroshi Suzuki
    Institute for Environmental Sciences, Graduate School of Nutritional and Environmental Sciences, University of Shizuoka, 52 1 Yada, Shizuoka shi 422 8526, Japan
    Environ Sci Technol 42:8076-82. 2008
    ..These results suggested that DNA-TiO2 is beneficial for the removal and degradation of chemicals having affinity for DNA and dispersing in a large field...
  20. ncbi request reprint Coexposure to benzo[a]pyrene and UVA induces DNA damage: first proof of double-strand breaks in a cell-free system
    Tatsushi Toyooka
    Laboratory of Radiation Biology, Graduate School of Nutritional and Environmental Sciences, University of Shizuoka, Shizuoka, Japan
    Environ Mol Mutagen 47:38-47. 2006
    ..Our findings indicate that coexposure to BaP and UVA effectively induced DNA damage, especially DSBs, which results in phototoxicity and possibly photocarcinogenesis...
  21. ncbi request reprint New method for testing phototoxicity of polycyclic aromatic hydrocarbons
    Tatsushi Toyooka
    Laboratory of Radiation Biology, Graduate School of Nutritional and Environmental Sciences, Institute for Environmental Sciences, University of Shizuoka, Shizuoka, Japan
    Environ Sci Technol 40:3603-8. 2006
    ..These findings suggest that histone H2AX is a potential moleculartargetfor detecting the phototoxicity of PAHs more sensitively than the detection of cell viability and DSBs...
  22. ncbi request reprint Co-exposure to benzo[a]pyrene and UVA induces phosphorylation of histone H2AX
    Tatsushi Toyooka
    Laboratory of Radiation Biology, Graduate School of Nutritional and Environmental Sciences, University of Shizuoka, 52 1, Yada, Shizuoka shi 422 8526, Japan
    FEBS Lett 579:6338-42. 2005
    ..NaN(3) effectively inhibited the formation of gamma-H2AX induced by co-exposure, indicating the contribution of singlet oxygen. This is the first evidence that co-exposure to BaP and UVA induced DSBs, involving gamma-H2AX...
  23. ncbi request reprint Dysregulation of apoptosis by benzene metabolites and their relationships with carcinogenesis
    Yuko Ibuki
    Laboratory of Radiation Biology, Graduate School of Nutritional and Environmental Sciences, University of Shizuoka, 52 1 Yada, Shizuoka 422 8526, Japan
    Biochim Biophys Acta 1690:11-21. 2004
    ..These findings suggested that benzene metabolites induced dysregulation of apoptosis due to caspase-3 inhibition, which contributes to carcinogenesis...
  24. doi request reprint Nonylphenol polyethoxylates induce phosphorylation of histone H2AX
    Tatsushi Toyooka
    Institute for Environmental Sciences, University of Shizuoka, 52 1, Yada, Suruga ku, Shizuoka shi, Shizuoka 422 8526, Japan
    Mutat Res 741:57-64. 2012
    ..The generation of γ-H2AX means the formation of DSBs, the worst type of DNA damage. The results indicated that attention should be paid to degradated short chain NPEOs and their genotoxicity...
  25. doi request reprint DNA can sediment TiO2 particles and decrease the uptake potential by mammalian cells
    Tatsushi Toyooka
    Laboratory of Radiation Biology, Institute for Environmental Science, Graduate School of Nutritional and Environmental Sciences, University of Shizuoka, Shizuoka, Japan
    Sci Total Environ 407:2143-50. 2009
    ..DNA is a useful tool for separating TiO(2) particles which would prevent "small-size specific toxicity" by allowing quick and complete recovery and suppression of uptake by living organisms...
  26. ncbi request reprint The antiapoptotic effect of low-dose UVB irradiation in NIH3T3 cells involves caspase inhibitions
    Yuko Ibuki
    Laboratory of Radiation Biology, Graduate School of Nutritional and Environmental Sciences, University of Shizuoka, Yada, Shizuoka shi, Japan
    Photochem Photobiol 77:276-83. 2003
    ....
  27. doi request reprint Phosphorylation of histone H2AX is a powerful tool for detecting chemical photogenotoxicity
    Tatsushi Toyooka
    Graduate School of Nutritional and Environmental Sciences, University of Shizuoka, Shizuoka, Japan
    J Invest Dermatol 131:1313-21. 2011
    ..H2AX was not generated following treatments with nonphototoxic chemicals and UVA. These results indicated that γ-H2AX is a powerful tool for detecting chemical photogenotoxicity...
  28. doi request reprint Benzo[a]pyrene exposed to solar-simulated light inhibits apoptosis and augments carcinogenicity
    Mai Teranishi
    Graduate School of Nutritional and Environmental Sciences, University of Shizuoka, Suruga ku, Shizuoka shi, Japan
    Chem Biol Interact 185:4-11. 2010
    ..The results suggested that the carcinogenicity of PAHs may be attributable not only to the genetic damage induced by their metabolites, but also to the antiapoptotic effects of oxidative products on exposure to sunlight...
  29. ncbi request reprint Change of estrogenic activity and release of chloride ion in chlorinated bisphenol a after exposure to ultraviolet B
    Yasuko Mutou
    Laboratory of Radiation Biology, Graduate School of Nutritional and Environmental Sciences, University of Shizuoka, Shizuoka, Japan
    Biol Pharm Bull 29:2116-9. 2006
    ..These findings suggested that UVB irradiation could decrease the estrogenic activity of chlorinated compounds, which was due to the selective release of chloride ion...
  30. doi request reprint Synergistic bactericidal effect by combined exposure to Ag nanoparticles and UVA
    Xiaoxu Zhao
    Institute for Environmental Sciences, University of Shizuoka, Shizuoka, Japan
    Sci Total Environ 458:54-62. 2013
    ..The synergistic use of AgNPs and UVA could become a powerful tool with broad antimicrobial applications...
  31. doi request reprint Dual effects of N-acetyl-L-cysteine dependent on NQO1 activity: suppressive or promotive of 9,10-phenanthrenequinone-induced toxicity
    Tatsushi Toyooka
    Graduate School of Nutritional and Environmental Sciences, University of Shizuoka, Shizuoka, Japan
    Toxicol Appl Pharmacol 264:404-12. 2012
    ..The results suggested that dual effects of NAC on the cyto- and genotoxicity of 9,10-PQ were dependent on tissue-specific NQO1 activity...
  32. ncbi request reprint Degradation of nonylphenol polyethoxylates by ultraviolet B irradiation and effects of their products on mammalian cultured cells
    Rensuke Goto
    Laboratory of Radiation Biology, Graduate School of Nutritional and Environmental Sciences, University of Shizuoka, 52 1 Yada, Shizuoka shi 422 8526, Japan
    Toxicology 202:237-47. 2004
    ..This study shows the significance of UV exposure to the degradation of alkylphenol polyethoxylates in the environment...
  33. doi request reprint Cigarette sidestream smoke induces phosphorylated histone H2AX
    Tatsushi Toyooka
    Laboratory of Radiation Biology, Graduate School of Nutritional and Environmental Sciences, University of Shizuoka, 52 1, Yada, Shizuoka shi 422 8526, Shizuoka, Japan
    Mutat Res 676:34-40. 2009
    ..CSS in fact induced DSBs, which was also inhibited by NAC. DSBs are the worst type of DNA damage, related to genomic instability and carcinogenesis. Our results would increase the evidence of the strong genotoxicity of passive smoking...
  34. ncbi request reprint Proteome analysis of UV-B-induced anti-apoptotic regulatory factors
    Yuko Ibuki
    Laboratory of Radiation Biology, Graduate School of Nutritional and Environmental Sciences, University of Shizuoka, Japan
    Photochem Photobiol 81:823-9. 2005
    ..The DIGE system used in this experiment has advantages (including a high level of statistical confidence) for discovering new functional proteins related to the regulation of apoptosis...
  35. ncbi request reprint Simple and easy method to evaluate uptake potential of nanoparticles in mammalian cells using a flow cytometric light scatter analysis
    Hiroshi Suzuki
    Laboratory of Radiation Biology, Institute for Environmental Sciences, Graduate School of Nutritional and Environmental Sciences, University of Shizuoka, 52 1 Yada, Shizuoka shi 422 8526, Japan
    Environ Sci Technol 41:3018-24. 2007
    ..The uptake of other nanoparticles such as silver (Ag) and iron oxide (Fe3O4) also could be detected. This method could be used for the initial screening of the uptake potential of nanoparticles as an index of "nanotoxicity"...
  36. ncbi request reprint Coexposure to benzo[a]pyrene plus UVA induced DNA double strand breaks: visualization of Ku assembly in the nucleus having DNA lesions
    Tatsushi Toyooka
    Laboratory of Radiation Biology, Graduate School of Nutritional and Environmental Sciences, University of Shizuoka, Shizuoka, Japan
    Biochem Biophys Res Commun 322:631-6. 2004
    ..Furthermore, we succeeded in visualizing that Ku80 rapidly assembled to the exposed region, in which DSBs might be generated, and clarified that the presence of both Ku70 and Ku80 was important for their accumulation...
  37. ncbi request reprint UVA irradiation induces energy-independent phospholipid-flip in mammalian plasma membrane
    Y Ibuki
    Laboratory of Radiation Biology, Graduate School of Nutritional and Environmental Sciences, University of Shizuoka, 52 1 Yada, Shizuoka shi 422 8526, Japan
    Photochem Photobiol 73:513-7. 2001
    ..These findings indicated that UVA changes the flip-flop of phospholipids and that the cell membrane is a molecular and cellular target of UVA...
  38. ncbi request reprint Suppression of apoptosis by UVB irradiation: survival signaling via PI3-kinase/Akt pathway
    Y Ibuki
    Laboratory of Radiation Biology, Graduate School of Nutritional and Environmental Sciences, University of Shizuoka, 52 1, Yada, Shizuoka shi, 422 8526, Japan
    Biochem Biophys Res Commun 279:872-8. 2000
    ..These results suggested that UVB irradiation transduced a survival signal via PI3 kinase activation and phosphorylation of Akt, and induced some apoptosis inhibition factors upstream of the caspase cascade...
  39. ncbi request reprint Ionizing radiation-induced macrophage activation: augmentation of nitric oxide production and its significance
    Y Ibuki
    Laboratory of Radiation Biology, Graduate School of Nutritional and Environmental Sciences, University of Shizuoka, Shizuoka shi 422 8526, Japan
    Cell Mol Biol (Noisy-le-grand) 50:OL617-26. 2004
    ..In radiotherapy, the control of NO levels both in whole-body and in the tumor is important to prevent irradiation-induced injury and for the cancer to regress...
  40. ncbi request reprint Enhancement of O2- production from resident peritoneal macrophages by low-dose in vivo gamma-irradiation
    Y Ibuki
    Laboratory of Radiation Biology, Graduate School of Nutritional and Environmental Sciences, University of Shizuoka, Japan
    Biol Pharm Bull 23:1094-6. 2000
    ..This may contribute to the increase of cytolytic activity of macrophages after low-dose in vivo irradiation...
  41. ncbi request reprint Contribution of inflammatory cytokine release to activation of resident peritoneal macrophages after in vivo low-dose gamma-irradiation
    Y Ibuki
    Laboratory of Radiation Biology, Graduate School of Nutritional and Environmental Sciences, University of Shizuoka, Japan
    J Radiat Res 40:253-62. 1999
    ....
  42. doi request reprint γ-H2AX induced by linear alkylbenzene sulfonates is due to deoxyribonuclease-1 translocation to the nucleus via actin disruption
    Xiaoxu Zhao
    Graduate Division of Nutritional and Environmental Sciences, University of Shizuoka, Shizuoka, Japan
    Mutat Res 777:33-42. 2015
    ..These results suggested that the LAS-induced generation of γ-H2AX could be attributed to the translocation of DNase I to the nucleus through the disruption of actin, and not to LAS-induced DNA damage. ..
  43. doi request reprint Phosphorylation of histone H2AX generated by linear alkylbenzene sulfonates and its suppression by UVB exposure
    Toru Kubota
    Institute for Environmental Sciences, University of Shizuoka, Shizuoka, Japan
    Photochem Photobiol 90:845-52. 2014
    ..UVB is an important environmental factor in the degradation of LAS exhibiting the ability to induce DSBs, the most serious type of DNA damage. ..
  44. ncbi request reprint gamma-Irradiation-induced DNA damage enhances NO production via NF-kappaB activation in RAW264.7 cells
    Yuko Ibuki
    Laboratory of Radiation Biology, Graduate School of Nutritional and Environmental Sciences, University of Shizuoka, 52 1, Yada, 422 8526, Shizuoka, Japan
    Biochim Biophys Acta 1593:159-67. 2003
    ..We concluded that (1) the increase in NO production was due to direct DNA damage by gamma-irradiation, and that (2) PARP activation through DNA damage induced NF-kappaB activation, leading to iNOS expression and NO production...
  45. ncbi request reprint Phosphatidylserine induces apoptosis in CHO cells without mitochondrial dysfunction in a manner dependent on caspases other than caspases-1, -3, -8 and -9
    Y Miyato
    Laboratory of Radiation Biology, Graduate School of Nutritional and Environmental Sciences, University of Shizuoka, Japan
    FEBS Lett 504:73-7. 2001
    ..These results suggest that PS-induced apoptosis occurs without the collapse of mitochondrial transmembrane potential and without the release of cytochrome c, in a manner independent of caspase-1, -3, -8 and -9...
  46. doi request reprint Coexposure to silver nanoparticles and ultraviolet A synergistically enhances the phosphorylation of histone H2AX
    Xiaoxu Zhao
    Graduate Division of Nutritional and Environmental Sciences, University of Shizuoka, 52 1 Yada, Suruga, Shizuoka 422 8526, Japan
    J Photochem Photobiol B 162:213-22. 2016
    ..Ag has been considered a safe metal; however, our results provide important insights into the influence of sunlight on the genotoxic potency of AgNPs. ..
  47. doi request reprint New mechanism of γ-H2AX generation: Surfactant-induced actin disruption causes deoxyribonuclease I translocation to the nucleus and forms DNA double-strand breaks
    Xiaoxu Zhao
    Graduate Division of Nutritional and Environmental Sciences, University of Shizuoka, Shizuoka, Japan
    Mutat Res Genet Toxicol Environ Mutagen 794:1-7. 2015
    ..This mechanism is distinct from the process of γ-H2AX generation caused by direct chemically induced DNA damage. ..
  48. doi request reprint Silver ions enhance UVB-induced phosphorylation of histone H2AX
    Xiaoxu Zhao
    Graduate Division of Nutritional and Environmental Sciences, University of Shizuoka, Shizuoka shi, Shizuoka, Japan
    Environ Mol Mutagen 55:556-65. 2014
    ..These lesions, if not repaired properly, are the major causal factor for skin carcinogenesis. Our results provide an important insight into influence of Ag on the genotoxic potency of sunlight...
  49. ncbi request reprint Antiapoptotic effects induced by different wavelengths of ultraviolet light
    Yuko Ibuki
    Laboratory of Radiation Biology, Graduate School of Nutritional and Environmental Sciences, University of Shizuoka, Japan
    Photochem Photobiol 75:495-502. 2002
    ..These results suggested the existence of two different survival pathways leading to suppression of apoptosis, one for UVA that is independent of the PI3-kinase-Akt pathway and the other for UVB and UVC that is dependent on this pathway...
  50. doi request reprint Histone deacetylase inhibitor sodium butyrate enhances the cell killing effect of psoralen plus UVA by attenuating nucleotide excision repair
    Tatsushi Toyooka
    Laboratory of Radiation Biology, Graduate School of Nutritional and Environmental Sciences, University of Shizuoka, Shizuoka, Japan
    Cancer Res 69:3492-500. 2009
    ..These results indicated that the enhanced cell killing effect of PUVA by SB was attributable to an attenuated ability to repair DNA and, especially, dysfunctional NER...
  51. ncbi request reprint Change of zinc uptake under growth arrest and apoptosis
    Atsushi Takeda
    Department of Medical Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka 422 8526, Japan
    Anticancer Res 24:3869-74. 2004
    ..The present study demonstrates that zinc uptake is involved not only in the process of cell proliferation, but also in the process of apoptosis...
  52. doi request reprint Evaluating the toxicity of silver nanoparticles by detecting phosphorylation of histone H3 in combination with flow cytometry side-scattered light
    Xiaoxu Zhao
    Graduate Division of Nutritional and Environmental Sciences, University of Shizuoka, 52 1, Yada, Suruga, Shizuoka, Shizuoka 422 8526, Japan
    Environ Sci Technol 49:5003-12. 2015
    ..Environ. Sci. Technol. 2007 , 41 ( 8 ), 3018 - 3024 ]. Our current findings suggest that p-H3S10 can be used to evaluate the toxicity of AgNPs and Ag ion release in combination with detection of side-scattered light from flow cytometry. ..
  53. doi request reprint Formaldehyde-induced histone H3 phosphorylation via JNK and the expression of proto-oncogenes
    Ikuma Yoshida
    Graduate Division of Nutritional and Environmental Sciences, University of Shizuoka, Shizuoka, Japan
    Mutat Res 770:9-18. 2014
    ..These results suggested that FA both initiates and promotes cancer, as judged by an analysis of histone modifications. ..
  54. doi request reprint Beneficial effects of curcumin on antitumor activity and adverse reactions of doxorubicin
    Yasuyuki Sadzuka
    School of Pharmacy, Iwate Medical University, 2 1 1 Nishitokuta, Yahaba Cho, Shiwa Gun, Iwate 028 3694, Japan
    Int J Pharm 432:42-9. 2012
    ..Therefore, it is expected that curcumin may reduce the adverse reactions associated with DOX. Our results suggest that curcumin can be used as a modulator to enhance the therapeutic index of cancer patients and improve their QOL...
  55. ncbi request reprint DNA damage induced by coexposure to PAHs and light
    Tatsushi Toyooka
    Laboratory of Radiation Biology, Graduate School of Nutritional and Environmental Sciences, University of Shizuoka, 52 1 Yada, Shizuoka shi 422 8526, Japan
    Environ Toxicol Pharmacol 23:256-63. 2007
    ..Some PAHs were recently proved to be photomutagenic. In this review, we discuss the influence of PAHs in combination with sunlight focusing on the phototoxicity and cellular DNA damage produced...
  56. ncbi request reprint Radiation sources providing increased UVA/UVB ratios attenuate the apoptotic effects of the UVB waveband UVA-dose-dependently in hairless mouse skin
    Yuko Ibuki
    Faculty of Veterinary Science, University of Sydney, Sydney, New South Wales, Australia
    J Invest Dermatol 127:2236-44. 2007
    ..The observations suggest that UVA reduces UVB-induced DNA damage, and may therefore have anti-photocarcinogenic properties that could be harnessed for better photoprotection in humans...
  57. ncbi request reprint Immunomodulatory effects of ultraviolet B irradiation on atopic dermatitis in NC/Nga mice
    Yasuko Mutou
    Department of Radiation Biosciences, Faculty of Pharmaceutical Sciences, Tokyo University of Science, Chiba, Japan
    Photodermatol Photoimmunol Photomed 23:135-44. 2007
    ..Recently, narrow-band ultraviolet B (UVB) phototherapy has been used to treat AD, but the mechanism involved is unknown. In this study, we investigated whether UVB irradiation influences AD in the NC/Nga mouse...