H Fukasawa

Summary

Affiliation: University of Tokyo
Country: Japan

Publications

  1. ncbi request reprint Enhancing effect of tumor promoters, phorbol esters and teleocidins on nuclear receptor-mediated transcription
    H Fukasawa
    Graduate School of Pharmaceutical Sciences, University of Tokyo, Japan
    Biol Pharm Bull 23:1414-7. 2000
  2. ncbi request reprint Oxygenated cholesterols as ligands for cytosolic-nuclear tumor promoter binding protein: yakkasteroids
    Y Endo
    Faculty of Pharmaceutical Sciences, University of Tokyo, Japan
    Biochem Biophys Res Commun 194:1529-35. 1993
  3. ncbi request reprint Enhancement of human papillomavirus type 18 gene expression in HeLa cells by 12-O-tetradecanoylphorbol-13-acetate, 3 beta,5 alpha-dihydroxycholestan-6-one, and cholesterol
    Y Matsushima
    Faculty of Pharmaceutical Sciences, University of Tokyo, Japan
    Biol Pharm Bull 17:1292-5. 1994
  4. ncbi request reprint Synthesis, computer modeling and biological evaluation of novel protein kinase C agonists based on a 7-membered lactam moiety
    Y Endo
    Graduate School of Pharmaceutical Sciences, University of Tokyo, Japan
    Bioorg Med Chem Lett 9:173-8. 1999
  5. ncbi request reprint Potent estrogen agonists based on carborane as a hydrophobic skeletal structure. A new medicinal application of boron clusters
    Y Endo
    Graduate School of Phamaceutical Sciences, University of Tokyo, Japan
    Chem Biol 8:341-55. 2001
  6. ncbi request reprint Novel retinoidal tropolone derivatives. Bioisosteric relationship of tropolone ring with benzoic acid moiety in retinoid structure
    M Ebisawa
    Graduate School of Pharmaceutical Sciences, The University of Tokyo, Japan
    Chem Pharm Bull (Tokyo) 49:501-3. 2001

Collaborators

Detail Information

Publications6

  1. ncbi request reprint Enhancing effect of tumor promoters, phorbol esters and teleocidins on nuclear receptor-mediated transcription
    H Fukasawa
    Graduate School of Pharmaceutical Sciences, University of Tokyo, Japan
    Biol Pharm Bull 23:1414-7. 2000
    ..These results suggest this reporter system is useful for the evaluation of effects on the gene expression of various tumor promoters, including non-TPA type...
  2. ncbi request reprint Oxygenated cholesterols as ligands for cytosolic-nuclear tumor promoter binding protein: yakkasteroids
    Y Endo
    Faculty of Pharmaceutical Sciences, University of Tokyo, Japan
    Biochem Biophys Res Commun 194:1529-35. 1993
    ..Investigation of the structure-activity relationships of yakkasteroids revealed that the structure of the side chain at the 20-position is important for the binding activity to CN-TPBP...
  3. ncbi request reprint Enhancement of human papillomavirus type 18 gene expression in HeLa cells by 12-O-tetradecanoylphorbol-13-acetate, 3 beta,5 alpha-dihydroxycholestan-6-one, and cholesterol
    Y Matsushima
    Faculty of Pharmaceutical Sciences, University of Tokyo, Japan
    Biol Pharm Bull 17:1292-5. 1994
    ..Treatment of the cells with cholesterol under serum-free conditions also resulted in an apparent increase of HPV18 expression...
  4. ncbi request reprint Synthesis, computer modeling and biological evaluation of novel protein kinase C agonists based on a 7-membered lactam moiety
    Y Endo
    Graduate School of Pharmaceutical Sciences, University of Tokyo, Japan
    Bioorg Med Chem Lett 9:173-8. 1999
    ..Computational docking simulation also indicates that the relative positions of the hydrogen-bonding sites and hydrophobic regions of the compounds are well matched to the PKC delta binding site...
  5. ncbi request reprint Potent estrogen agonists based on carborane as a hydrophobic skeletal structure. A new medicinal application of boron clusters
    Y Endo
    Graduate School of Phamaceutical Sciences, University of Tokyo, Japan
    Chem Biol 8:341-55. 2001
    ..However, these features of carboranes may allow another application as a hydrophobic pharmacophore in biologically active molecules that interact hydrophobically with receptors...
  6. ncbi request reprint Novel retinoidal tropolone derivatives. Bioisosteric relationship of tropolone ring with benzoic acid moiety in retinoid structure
    M Ebisawa
    Graduate School of Pharmaceutical Sciences, The University of Tokyo, Japan
    Chem Pharm Bull (Tokyo) 49:501-3. 2001
    ..The activities of the tropolones were greatly enhanced in the presence of HX630, an RXR agonist (retinoid synergist)...