Hirotaka Chikuda

Summary

Affiliation: University of Tokyo
Country: Japan

Publications

  1. doi request reprint Ischemic stroke after cervical spine injury: analysis of 11,005 patients using the Japanese Diagnosis Procedure Combination database
    Hirotaka Chikuda
    Department of Orthopaedic Surgery, Faculty of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan Electronic address
    Spine J 14:2275-80. 2014
  2. pmc Optimal treatment for spinal cord injury associated with cervical canal stenosis (OSCIS): a study protocol for a randomized controlled trial comparing early versus delayed surgery
    Hirotaka Chikuda
    Department of Orthopaedic Surgery, Faculty of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Trials 14:245. 2013
  3. doi request reprint Mortality and morbidity in dialysis-dependent patients undergoing spinal surgery: analysis of a national administrative database in Japan
    Hirotaka Chikuda
    Department of Orthopaedic Surgery, Faculty of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    J Bone Joint Surg Am 94:433-8. 2012
  4. pmc Correlation between pyramidal signs and the severity of cervical myelopathy
    Hirotaka Chikuda
    Department of Orthopaedic Surgery, Faculty of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Eur Spine J 19:1684-9. 2010
  5. doi request reprint Radiographic analysis of the cervical spine in patients with retro-odontoid pseudotumors
    Hirotaka Chikuda
    Department of Orthopaedic Surgery, Faculty of Medicine, The University of Tokyo, Tokyo, Japan
    Spine (Phila Pa 1976) 34:E110-4. 2009
  6. ncbi request reprint Mutation in cGMP-dependent protein kinase II causes dwarfism in a rat mutant KMI through uncoupling of proliferation and differentiation of chondrocytes
    Hirotaka Chikuda
    Department of Sensory and Motor System Medicine, Faculty of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    J Bone Miner Metab 23:200-4. 2005
  7. doi request reprint Acute cervical spinal cord injury complicated by preexisting ossification of the posterior longitudinal ligament: a multicenter study
    Hirotaka Chikuda
    Department of Orthopaedic Surgery, University of Tokyo, Tokyo, Japan
    Spine (Phila Pa 1976) 36:1453-8. 2011
  8. pmc Phosphorylation of GSK-3beta by cGMP-dependent protein kinase II promotes hypertrophic differentiation of murine chondrocytes
    Yosuke Kawasaki
    Sensory and Motor System Medicine, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    J Clin Invest 118:2506-15. 2008
  9. ncbi request reprint Involvement of endogenous bone morphogenetic protein (BMP) 2 and BMP6 in bone formation
    Fumitaka Kugimiya
    Division of Tissue Engineering, Faculty of Medicine, University of Tokyo, Hongo 7 3 1, Bunkyo, Tokyo, 113 8655, Japan
    J Biol Chem 280:35704-12. 2005
  10. pmc Cyclic GMP-dependent protein kinase II is a molecular switch from proliferation to hypertrophic differentiation of chondrocytes
    Hirotaka Chikuda
    Department of Sensory and Motor System Medicine, Faculty of Medicine, University of Tokyo, Bunkyo, Tokyo 113 8655, Japan
    Genes Dev 18:2418-29. 2004

Collaborators

Detail Information

Publications63

  1. doi request reprint Ischemic stroke after cervical spine injury: analysis of 11,005 patients using the Japanese Diagnosis Procedure Combination database
    Hirotaka Chikuda
    Department of Orthopaedic Surgery, Faculty of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan Electronic address
    Spine J 14:2275-80. 2014
    ..The incidence and relevant risk of ischemic stroke after cervical spine trauma remain unknown...
  2. pmc Optimal treatment for spinal cord injury associated with cervical canal stenosis (OSCIS): a study protocol for a randomized controlled trial comparing early versus delayed surgery
    Hirotaka Chikuda
    Department of Orthopaedic Surgery, Faculty of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Trials 14:245. 2013
    ....
  3. doi request reprint Mortality and morbidity in dialysis-dependent patients undergoing spinal surgery: analysis of a national administrative database in Japan
    Hirotaka Chikuda
    Department of Orthopaedic Surgery, Faculty of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    J Bone Joint Surg Am 94:433-8. 2012
    ....
  4. pmc Correlation between pyramidal signs and the severity of cervical myelopathy
    Hirotaka Chikuda
    Department of Orthopaedic Surgery, Faculty of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Eur Spine J 19:1684-9. 2010
    ..Considering their low sensitivity in patients with mild disability, the pyramidal signs may have limited utility in early diagnosis of cervical myelopathy...
  5. doi request reprint Radiographic analysis of the cervical spine in patients with retro-odontoid pseudotumors
    Hirotaka Chikuda
    Department of Orthopaedic Surgery, Faculty of Medicine, The University of Tokyo, Tokyo, Japan
    Spine (Phila Pa 1976) 34:E110-4. 2009
    ..A retrospective review of 10 consecutive patients with a noninflammatory retro-odontoid pseudotumor...
  6. ncbi request reprint Mutation in cGMP-dependent protein kinase II causes dwarfism in a rat mutant KMI through uncoupling of proliferation and differentiation of chondrocytes
    Hirotaka Chikuda
    Department of Sensory and Motor System Medicine, Faculty of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    J Bone Miner Metab 23:200-4. 2005
  7. doi request reprint Acute cervical spinal cord injury complicated by preexisting ossification of the posterior longitudinal ligament: a multicenter study
    Hirotaka Chikuda
    Department of Orthopaedic Surgery, University of Tokyo, Tokyo, Japan
    Spine (Phila Pa 1976) 36:1453-8. 2011
    ..Retrospective multicenter study...
  8. pmc Phosphorylation of GSK-3beta by cGMP-dependent protein kinase II promotes hypertrophic differentiation of murine chondrocytes
    Yosuke Kawasaki
    Sensory and Motor System Medicine, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    J Clin Invest 118:2506-15. 2008
    ..These data indicate that hypertrophic differentiation of growth plate chondrocytes during skeletal growth is promoted by phosphorylation and inactivation of GSK-3beta by cGKII...
  9. ncbi request reprint Involvement of endogenous bone morphogenetic protein (BMP) 2 and BMP6 in bone formation
    Fumitaka Kugimiya
    Division of Tissue Engineering, Faculty of Medicine, University of Tokyo, Hongo 7 3 1, Bunkyo, Tokyo, 113 8655, Japan
    J Biol Chem 280:35704-12. 2005
    ..We thus concluded that endogenous BMP2 and BMP6 cooperatively play pivotal roles in bone formation under both physiological and pathological conditions...
  10. pmc Cyclic GMP-dependent protein kinase II is a molecular switch from proliferation to hypertrophic differentiation of chondrocytes
    Hirotaka Chikuda
    Department of Sensory and Motor System Medicine, Faculty of Medicine, University of Tokyo, Bunkyo, Tokyo 113 8655, Japan
    Genes Dev 18:2418-29. 2004
    ....
  11. pmc GSK-3beta controls osteogenesis through regulating Runx2 activity
    Fumitaka Kugimiya
    Center for Disease Biology and Integrative Medicine, University of Tokyo, Tokyo, Japan
    PLoS ONE 2:e837. 2007
    ..These results establish GSK-3beta as a key attenuator of Runx2 activity in bone formation and as a potential molecular target for clinical treatment of bone catabolic disorders like cleidocranial dysplasia...
  12. doi request reprint Factors affecting the occurrence of pulmonary embolism after spinal surgery: data from the national administrative database in Japan
    Kazuhiro Masuda
    Department of Orthopedic Surgery, Faculty of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Spine J 12:1029-34. 2012
    ..To the best of our knowledge, few large studies have examined the prevalence and risk factors of PE after spinal surgery...
  13. doi request reprint Is a right pedicle screw always away from the aorta in scoliosis?
    Katsushi Takeshita
    Department of Orthopaedic Surgery, The University of Tokyo, Tokyo, Japan
    Spine (Phila Pa 1976) 36:E1519-24. 2011
    ..Retrospective analysis...
  14. doi request reprint Aorta movement in patients with scoliosis after posterior surgery
    Katsushi Takeshita
    Department of Orthopaedic Surgery, The University of Tokyo, Tokyo, Japan
    Spine (Phila Pa 1976) 35:E1571-6. 2010
    ..Retrospective analysis...
  15. ncbi request reprint Ossification of the posterior atlantoaxial membrane associated with an os odontoideum: a case report
    Junichi Ohya
    Department of Orthopaedic Surgery, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    J Orthop Surg (Hong Kong) 19:392-4. 2011
    ..Long-standing atlantoaxial instability might have played a role in ectopic ossification of the posterior atlantoaxial membrane...
  16. pmc New parameters to represent the position of the aorta relative to the spine for pedicle screw placement
    Katsushi Takeshita
    Department of Orthopaedic Surgery, Faculty of Medicine, The University of Tokyo, 7 3 1, Hongo, Bunkyo ku, Tokyo, 113 8655, Japan
    Eur Spine J 19:815-20. 2010
    ..These new parameters enable surgeons to intuitively understand the position of the aorta in surgical planning or in placement of a pedicle screw...
  17. ncbi request reprint Inhibition of Cdk6 expression through p38 MAP kinase is involved in differentiation of mouse prechondrocyte ATDC5
    Toru Moro
    Department of Sensory and Motor System Medicine, Faculty of Medicine, University of Tokyo, Japan
    J Cell Physiol 204:927-33. 2005
    ..These results indicate that Cdk6 may be a regulator of chondrocyte differentiation and that its p38-mediated downregulation is involved in the efficient differentiation...
  18. ncbi request reprint The canonical Wnt signaling pathway promotes chondrocyte differentiation in a Sox9-dependent manner
    Fumiko Yano
    Division of Tissue Engineering, Faculty of Medicine, University of Tokyo, Hongo 7 3 1, Bunkyo, Tokyo 113 8655, Japan
    Biochem Biophys Res Commun 333:1300-8. 2005
    ..The response of Sox9-deficient cells was restored by the adenoviral expression of Sox9. Thus, the canonical Wnt signaling pathway promotes chondrocyte differentiation in a Sox9-dependent manner...
  19. doi request reprint Normative score and cut-off value of the Neck Disability Index
    So Kato
    The Department of Orthopaedic Surgery, Sensory and Motor System Medicine, Surgical Sciences, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0003, Japan
    J Orthop Sci 17:687-93. 2012
    ..The objective of the present study was to determine the normative score and the cut-off value of the NDI...
  20. doi request reprint Natural course and prognostic factors in patients with mild cervical spondylotic myelopathy with increased signal intensity on T2-weighted magnetic resonance imaging
    Yasushi Oshima
    Department of Orthopaedic Surgery, The University of Tokyo, Bunkyo ku, Japan
    Spine (Phila Pa 1976) 37:1909-13. 2012
    ..A retrospective comparative study...
  21. ncbi request reprint Contribution of runt-related transcription factor 2 to the pathogenesis of osteoarthritis in mice after induction of knee joint instability
    Satoru Kamekura
    Faculty of Medicine, University of Tokyo, Tokyo, Japan
    Arthritis Rheum 54:2462-70. 2006
    ..By producing instability in mouse knee joints, we attempted to determine the involvement of runt-related transcription factor 2 (RUNX-2), which is required for chondrocyte hypertrophy, in the development of osteoarthritis (OA)...
  22. doi request reprint A novel disease-modifying osteoarthritis drug candidate targeting Runx1
    Fumiko Yano
    Center for Disease Biology and Integrative Medicine, Faculty of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Ann Rheum Dis 72:748-53. 2013
    ..To identify a new disease-modifying osteoarthritis drug (DMOAD) candidate that can effectively repair cartilage by promoting chondrogenic differentiation and halt osteoarthritis (OA) progression by suppressing aberrant hypertrophy...
  23. ncbi request reprint Effect of Preoperative Sagittal Balance on Cervical Laminoplasty Outcomes
    Yasushi Oshima
    Department of Orthopedic Surgery, University of Tokyo, Tokyo, Japan Department of Orthopedics, Jichi Medical University Department of Medical Research and Management for Musculoskeletal Pain, 22nd Century Medical and Research Center, The University of Tokyo
    Spine (Phila Pa 1976) 41:E1265-E1270. 2016
    ..Retrospective case series...
  24. ncbi request reprint Involvement of cyclic guanosine monophosphate-dependent protein kinase II in chondrocyte hypertrophy during endochondral ossification
    Fumitaka Kugimiya
    Division of Sensory and Motor System Medicine, Faculty of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, 113 8655, Japan
    Mod Rheumatol 15:391-6. 2005
    ..Herein, we review the molecular mechanism of regulation of chondrocyte hypertrophy by cGKII and the interaction between cGKII and other signaling pathways...
  25. doi request reprint Cervical canal stenosis caused by progressive fusion and enlargement of cervical vertebrae with features of Proteus syndrome and Klippel-Feil syndrome
    Shurei Sugita
    Department of Orthopaedic Surgery, The University of Tokyo, Hongo 7 3 1, Bunkyo, Tokyo, Japan
    Skeletal Radiol 42:1743-6. 2013
    ..Our report may help expand the knowledge on developmental spine disorders. ..
  26. doi request reprint Modified fenestration with restorative spinoplasty for lumbar spinal stenosis
    Ko Matsudaira
    Department of Orthopedics, Faculty of Medicine, Tokyo University, Bunkyo ku, Tokyo, Japan
    J Neurosurg Spine 10:587-94. 2009
    ..The MFRS technique produces an adequate and safe decompression of the spinal canal, even in patients with narrow and steep facet joints in whom conventional fenestration is technically demanding...
  27. doi request reprint Radiographical risk factors for major intraoperative blood loss during laminoplasty in patients with ossification of the posterior longitudinal ligament
    So Kato
    Department of Orthopaedic Surgery, Sensory and Motor System Medicine, Surgical Sciences, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Spine (Phila Pa 1976) 37:E1588-93. 2012
    ..A retrospective multi-institutional study...
  28. pmc Sleep apnea in rheumatoid arthritis patients with occipitocervical lesions: the prevalence and associated radiographic features
    Naoki Shoda
    Department of Orthopaedic Surgery, Faculty of Medicine, The University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo, 113 8655, Japan
    Eur Spine J 18:905-10. 2009
    ..Small ADI and short neck, secondary to the vertical translocation by RA, may cause obstructive sleep apnea, probably through mechanical or neurological collapse of the upper airway...
  29. doi request reprint Patient Satisfaction with Posterior Decompression Surgery for Cervical Ossification of the Posterior Longitudinal Ligament: Prognostic Radiographic Factors and Patient-Reported Outcomes for the Effectiveness of Surgical Treatment
    Junichi Ohya
    Department of Orthopedic Surgery, The University of Tokyo, Tokyo, Japan Electronic address
    World Neurosurg 96:272-279. 2016
    ..To identify the prognostic factors associated with patient satisfaction after double-door laminoplasty for cervical compression myelopathy due to ossification of the posterior longitudinal ligament (OPLL)...
  30. doi request reprint Risk of infectious complications associated with blood transfusion in elective spinal surgery-a propensity score matched analysis
    So Kato
    Department of Orthopaedic Surgery, Sensory and Motor System Medicine, Surgical Sciences, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, 113 8655, Japan Electronic address
    Spine J 16:55-60. 2016
    ..Although the negative aspects of blood transfusion are increasingly recognized, less is known about transfusion-related risks in spinal surgery...
  31. ncbi request reprint Identification of an alternatively spliced variant of Ca2+-promoted Ras inactivator as a possible regulator of RANKL shedding
    Atsuhiko Hikita
    Department of Orthopaedic Surgery, Faculty of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    J Biol Chem 280:41700-6. 2005
    ..These results suggest that deltaCAPRI is a possible regulator of RANKL shedding by modulating MMP14 expression through Ras signaling cascades other than the Erk pathway...
  32. doi request reprint Use of Doppler ultrasonography to detect an elusive communication of a spinal extradural arachnoid cyst
    Masakazu Kanetaka
    Department of Orthopaedic Surgery, Faculty of Medicine, The University of Tokyo, Bunkyo ku, Tokyo 113 8655, Japan
    J Clin Neurosci 18:863-4. 2011
    ..Doppler ultrasonography may be a helpful adjunct for identifying the location of elusive communication in a spinal extradural arachnoid cyst...
  33. doi request reprint Diameter, length, and direction of pedicle screws for scoliotic spine: analysis by multiplanar reconstruction of computed tomography
    Katsushi Takeshita
    Department of Orthopaedic Surgery, The University of Tokyo, Tokyo, Japan
    Spine (Phila Pa 1976) 34:798-803. 2009
    ..A morphometric study of thoracic and lumbar spine in scoliosis...
  34. doi request reprint Mortality and morbidity after spinal surgery in patients with parkinson's disease: a retrospective matched-pair cohort study
    Takeshi Oichi
    Department of Orthopaedic Surgery, Sensory and Motor System Medicine, Surgical Sciences, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Spine J . 2016
    ..There is a lack of information about postoperative outcomes and related risk factors associated with spinal surgery in patients with Parkinson's disease (PD)...
  35. ncbi request reprint Seasonal Variations in the Risk of Reoperation for Surgical Site Infection Following Elective Spinal Fusion Surgery: A Retrospective Study Using the Japanese Diagnosis Procedure Combination Database
    Junichi Ohya
    Department of Orthopaedic Surgery, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan Department of Clinical Epidemiology and Health Economics, School of Public Health, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Spine (Phila Pa 1976) . 2016
    ..Retrospective study of data abstracted from the Diagnosis Procedure Combination (DPC) database, a national representative database in Japan...
  36. doi request reprint Cervical Anterolisthesis: A Predictor of Poor Neurological Outcomes in Cervical Spondylotic Myelopathy Patients After Cervical Laminoplasty
    Takeshi Oichi
    Department of Orthopedic Surgery, The University of Tokyo Hospital, Tokyo, Japan Department of Orthopedic Surgery, Jichi Medical University, Shimotsuke shi, Tochigi ken, Japan
    Spine (Phila Pa 1976) 41:E467-73. 2016
    ..A retrospective cohort study...
  37. doi request reprint Elevated levels of phosphorylated neurofilament heavy subunit in the cerebrospinal fluid of patients with lumbar spinal stenosis: preliminary findings
    Junichi Ohya
    Department of Orthopaedic Surgery, The University of Tokyo, 7 3 1 Hongo, Tokyo 113 8655, Japan
    Spine J 15:1587-92. 2015
    ..Although the previous studies have reported elevated CSF levels of pNfH in various neurological diseases, including amyotrophic lateral sclerosis, these levels have not been examined in patients with spinal stenosis...
  38. doi request reprint Phosphorylated neurofilament subunit levels in the serum of cervical compressive myelopathy patients
    So Kato
    Department of Orthopaedic Surgery, Faculty of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    J Clin Neurosci 22:1638-42. 2015
    ..Our results suggest that an elevated serum level of pNF-H is associated with an acute worsening of myelopathy and that a positive conversion of pNF-H after surgery is a marker of perioperative neural damage...
  39. doi request reprint Risks of in-hospital death and complications after fusion surgery in patients with atlantoaxial subluxation: analysis of 1090 patients using the Japanese Diagnosis Procedure Combination database
    Junichi Ohya
    Department of Orthopaedic Surgery, Faculty of Medicine, The University of Tokyo, Tokyo, Japan Electronic address
    World Neurosurg 83:603-7. 2015
    ....
  40. doi request reprint Patient satisfaction with double-door laminoplasty for cervical compression myelopathy
    Junichi Ohya
    Department of Orthopaedic Surgery, Faculty of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, 113 0033, Japan
    J Orthop Sci 20:64-70. 2015
    ..This study aimed to investigate patient satisfaction after double-door laminoplasty for cervical compression myelopathy, and to identify the postoperative patient-reported outcomes associated with patient satisfaction...
  41. pmc Mortality and morbidity after high-dose methylprednisolone treatment in patients with acute cervical spinal cord injury: a propensity-matched analysis using a nationwide administrative database
    Hirotaka Chikuda
    Department of Orthopaedic Surgery, Faculty of Medicine, The University of Tokyo, Tokyo, Japan
    Emerg Med J 31:201-6. 2014
    ..To examine the magnitude of the adverse impact of high-dose methylprednisolone treatment in patients with acute cervical spinal cord injury (SCI)...
  42. pmc Distinct roles of Smad pathways and p38 pathways in cartilage-specific gene expression in synovial fibroblasts
    Hiroaki Seto
    Department of Orthopaedic Surgery, Faculty of Medicine, The University of Tokyo, Tokyo, Japan
    J Clin Invest 113:718-26. 2004
    ....
  43. pmc Correlations of Cervical Sagittal Alignment before and after Occipitocervical Fusion
    Yoshitaka Matsubayashi
    Department of Orthopaedic Surgery, The University of Tokyo, Tokyo, Japan
    Global Spine J 6:362-9. 2016
    ....
  44. doi request reprint Postoperative outcomes of major lower extremity amputations in patients with diabetes and peripheral artery disease: analysis using the Diagnosis Procedure Combination database in Japan
    Keiko Yamada
    Department of Clinical Epidemiology and Health Economics, School of Public Health, The University of Tokyo, Tokyo, Japan
    Am J Surg 212:446-50. 2016
    ..The purpose of the present study was to investigate 30-day postoperative outcomes after lower extremity amputation in patients with diabetes mellitus (DM) alone, peripheral artery disease (PAD) alone, or both...
  45. pmc Perioperative stroke in patients undergoing elective spinal surgery: a retrospective analysis using the Japanese diagnosis procedure combination database
    Junichi Ohya
    Department of Orthopaedic Surgery, Faculty of Medicine, The University of Tokyo, Hongo 7 3 1, Bunkyo, Tokyo, Japan
    BMC Musculoskelet Disord 16:276. 2015
    ....
  46. pmc Comparison of the Japanese Orthopaedic Association (JOA) score and modified JOA (mJOA) score for the assessment of cervical myelopathy: a multicenter observational study
    So Kato
    Department of Orthopaedic Surgery, The University of Tokyo, Tokyo, Japan
    PLoS ONE 10:e0123022. 2015
    ..The objective of the present study is to compare these scales and clarify their differences and interchangeability and verify their validity by comparing them to other outcome measures...
  47. pmc Clinical characteristics of rheumatoid arthritis patients undergoing cervical spine surgery: an analysis of National Database of Rheumatic Diseases in Japan
    Shurei Sugita
    The Department of Orthopaedic Surgery, The University of Tokyo, Hongo 7 3 1, Bunkyo, Tokyo, Japan
    BMC Musculoskelet Disord 15:203. 2014
    ..The aim of this study was to examine the clinical characteristics of rheumatoid arthritis (RA) patients who underwent cervical spine surgery using a multicenter observational database...
  48. doi request reprint Usefulness of QuickDASH in patients with cervical laminoplasty
    Hideki Nakamoto
    Department of Orthopedic Surgery, Faculty of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, 113 8655, Japan
    J Orthop Sci 19:218-22. 2014
    ....
  49. pmc The normative score and the cut-off value of the Oswestry Disability Index (ODI)
    Juichi Tonosu
    Department of Orthopedic Surgery, Faculty of Medicine, The University of Tokyo, Tokyo, Japan
    Eur Spine J 21:1596-602. 2012
    ..The purpose of this study was to estimate the normative score by adjusting the data for age distribution in Japan, and to determine the cut-off value which separates LBP with disability from LBP without disability...
  50. doi request reprint C7 sagittal vertical axis is the determinant of the C5-C7 angle in cervical sagittal alignment
    Yoshitaka Matsubayashi
    Department of Orthopaedic Surgery, Faculty of Medicine, The University of Tokyo, 7 3 1, Hongo, Bunkyo ku, Tokyo 113 8655, Japan Electronic address
    Spine J . 2016
    ..Previous studies have indicated that the T1 slope correlates with cervical lordosis. In contrast, the specific impact of the C7 sagittal vertical axis (C7SVA) on cervical lordosis remains unknown...
  51. pmc Relationship between Neuropathic Pain and Obesity
    Jun Hozumi
    Department of Anesthesiology and Pain Relief Center, The University of Tokyo Hospital, Tokyo 113 8655, Japan
    Pain Res Manag 2016:2487924. 2016
    ..Paroxysmal pain was more severe, suggesting that neural damage might be aggravated by obesity-associated inflammation. These findings should have needed to be confirmed in future studies. ..
  52. ncbi request reprint Thoracic intradural extramedullary lesions causing progressive myelopathy as an initial manifestation of granulomatosis with polyangiitis: a case report and review of literature
    Yuki Taniguchi
    a Department of Orthopedic Surgery, The University of Tokyo Hospital, Tokyo, Japan
    J Spinal Cord Med . 2016
    ..However, all these cases reportedly exhibited epidural tumor-like lesions or dural thickening...
  53. doi request reprint Evaluation of Comorbidity Indices for a Study of Patient Outcomes Following Cervical Decompression Surgery: A Retrospective Cohort Study
    Takeshi Oichi
    Department of Orthopedic Surgery, The University of Tokyo Hospital, 7 3 1 Hongo, Bunkyo ku, Tokyo, Japan Department of Orthopedic Surgery, Jichi Medical University Hospital, 3311 1 Yakushiji, Shimotsuke City, Tochigi, Japan
    Spine (Phila Pa 1976) 40:1941-7. 2015
    ..Retrospective cohort study...
  54. doi request reprint Progression of ossification of the posterior longitudinal ligament of the thoracic spine following posterior decompression and stabilization
    Shurei Sugita
    Department of Orthopaedic Surgery, Faculty of Medicine, University of Tokyo, Tokyo and
    J Neurosurg Spine 21:773-7. 2014
    ..It is also unknown whether patients' clinical symptoms worsen as OPLL size increases. In this retrospective case series study, the authors examined the postoperative progression of thoracic OPLL...
  55. doi request reprint Morphological characteristics of cervical spine in patients with athetoid cerebral palsy and the accuracy of pedicle screw placement
    So Kato
    Department of Orthopaedic Surgery, Sensory and Motor System Medicine, Surgical Sciences, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan and Department of Orthopaedics, Jichi Medical University, Shimotsuke, Japan
    Spine (Phila Pa 1976) 39:E508-13. 2014
    ..A retrospective study...
  56. doi request reprint Long-term follow-up of the progression of ossification of the posterior longitudinal ligament
    Motoaki Murakami
    Department of Orthopaedic Surgery, Faculty of Medicine, The University of Tokyo, Bunkyo ku, Tokyo, Japan
    J Neurosurg Spine 12:577-9. 2010
    ..Segmental-type OPLL developed into mixed-type extensive OPLL. This case shows an accelerating maturation process of OPLL over the course of a few years. Segmental-type OPLL appears to represent an initial stage of extensive OPLL...
  57. pmc Extensive ossification of the paraspinal ligaments in a patient with vitamin D-resistant rickets: Case report with literature review
    Yujiro Hirao
    Department of Orthopaedic Surgery, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan Electronic address
    Int J Surg Case Rep 27:125-128. 2016
    ..Ectopic ossification of the spinal ligaments is not uncommon in patients with Vitamin D-resistant rickets (VDRR), but the long-term consequences of this condition have not been reported...
  58. pmc Pyogenic discitis due to Abiotrophia adiacens
    Kosuke Uehara
    Department of Orthopaedic Surgery, Faculty of Medicine, The University of Tokyo, Tokyo, Japan Electronic address
    Int J Surg Case Rep 4:1107-9. 2013
    ..Abiotrophia species have been referred to as nutritionally variant streptococci because of their fastidious nutritional requirements for growth. Abiotrophia species are difficult to identify with conventional solid culture...
  59. doi request reprint Postsurgical spinal magnetic resonance imaging with iterative decomposition of water and fat with echo asymmetry and least-squares estimation
    Mizuho Murakami
    Department of Radiology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    J Comput Assist Tomogr 35:16-20. 2011
    ..Here, we compared postsurgical spinal MRI with IDEAL versus chemical shift selective saturation (CHESS)...
  60. ncbi request reprint Impairment of bone healing by insulin receptor substrate-1 deficiency
    Takashi Shimoaka
    Departments of Orthopaedic Surgery, Tissue Engineering, and Metabolic Diseases, Faculty of Medicine, University of Tokyo, Hongo, Bunkyo, Tokyo 113 8655, Japan
    J Biol Chem 279:15314-22. 2004
    ....
  61. pmc Use of C2 spinous process screw for posterior cervical fixation as substitute for laminar screw in a patient with thin laminae
    Kosei Nagata
    Department of Orthopaedic Surgery, Faculty of Medicine, The University of Tokyo Hospital, Tokyo, Japan
    BMJ Case Rep 2013:. 2013
    ..Spinous process screw can be an option of C2 fixation for patients with high-riding VA and severe degenerated cervical spines including thin C2 laminas. ..
  62. pmc Acute obstructive hydrocephalus complicating decompression surgery of the craniovertebral junction
    Junichi Ohya
    Department of Orthopaedic Surgery, Faculty of Medicine, The University of Tokyo, Tokyo 113 8655, Japan
    Asian J Neurosurg 11:311-2. 2016
    ..Acute obstructive hydrocephalus can occur late after decompression surgery at the CVJ, and thus should be included in the differential diagnosis of a deteriorating mental status. ..