T Azuma

Summary

Affiliation: University of Fukui
Country: Japan

Publications

  1. pmc Gastric leptin and Helicobacter pylori infection
    T Azuma
    Second Department of Internal Medicine, Fukui Medical University, Fukui, Japan
    Gut 49:324-9. 2001
  2. ncbi Eradication of Helicobacter pylori infection induces an increase in body mass index
    T Azuma
    Second Department of Internal Medicine, Fukui Medical University, Matsuoka cho, Yoshida gun, Fukui, Japan
    Aliment Pharmacol Ther 16:240-4. 2002
  3. ncbi The effects of cure of Helicobacter pylori infection on the signal transduction of gastric epithelial cells
    T Azuma
    Second Department of Internal Medicine, Fukui Medical University, Fukui 910 1193, Japan
    Aliment Pharmacol Ther 18:39-44. 2003
  4. ncbi Association between diversity in the Src homology 2 domain--containing tyrosine phosphatase binding site of Helicobacter pylori CagA protein and gastric atrophy and cancer
    Takeshi Azuma
    Second Department of Internal Medicine, Fukui Medical University, Fukui, Japan
    J Infect Dis 189:820-7. 2004
  5. ncbi Diversity of vacA and cagA genes of Helicobacter pylori in Japanese children
    T Azuma
    Second Department of Internal Medicine, Fukui Medical University, Fukui, Japan
    Aliment Pharmacol Ther 20:7-12. 2004
  6. ncbi The effect of Helicobacter pylori eradication therapy on dyspepsia symptoms in industrial workers in Japan
    T Azuma
    Second Department of Internal Medicine, Fukui Medical University, Fukui, Japan
    Aliment Pharmacol Ther 15:805-11. 2001
  7. pmc Distinct diversity of the cag pathogenicity island among Helicobacter pylori strains in Japan
    Takeshi Azuma
    Second Department of Internal Medicine, Faculty of Medical Science, University of Fukui Matsuoka cho, Yoshida gun, Fukui 910 1193, Japan
    J Clin Microbiol 42:2508-17. 2004
  8. ncbi Pharmacokinetics of clarithromycin in Helicobacter pylori eradication therapy in patients with liver cirrhosis
    T Azuma
    Second Department of Internal Medicine, Faculty of Medicine, Fukui Medical University, Japan
    Aliment Pharmacol Ther 14:216-22. 2000
  9. ncbi Correlation between variation of the 3' region of the cagA gene in Helicobacter pylori and disease outcome in Japan
    Takeshi Azuma
    Second Department of Internal Medicine, Fukui Medical University, Japan
    J Infect Dis 186:1621-30. 2002
  10. pmc Sequence analysis and clinical significance of the iceA gene from Helicobacter pylori strains in Japan
    Y Ito
    Second Department of Internal Medicine, Fukui Medical University, Fukui, Japan
    J Clin Microbiol 38:483-8. 2000

Collaborators

Detail Information

Publications65

  1. pmc Gastric leptin and Helicobacter pylori infection
    T Azuma
    Second Department of Internal Medicine, Fukui Medical University, Fukui, Japan
    Gut 49:324-9. 2001
    ..Leptin regulates feeding behaviour and therefore may be a mediator of anorexia associated with acute and chronic inflammation. Recently, leptin mRNA and leptin protein were found in the gastric epithelium...
  2. ncbi Eradication of Helicobacter pylori infection induces an increase in body mass index
    T Azuma
    Second Department of Internal Medicine, Fukui Medical University, Matsuoka cho, Yoshida gun, Fukui, Japan
    Aliment Pharmacol Ther 16:240-4. 2002
    ..The relationship between H. pylori infection and body mass indices is controversial...
  3. ncbi The effects of cure of Helicobacter pylori infection on the signal transduction of gastric epithelial cells
    T Azuma
    Second Department of Internal Medicine, Fukui Medical University, Fukui 910 1193, Japan
    Aliment Pharmacol Ther 18:39-44. 2003
    ..Translocated CagA forms a physical complex with the SRC homology 2 domain (SH2)-containing tyrosine phosphatase SHP-2, which plays an important role in mitogenic signal transduction in the host cells...
  4. ncbi Association between diversity in the Src homology 2 domain--containing tyrosine phosphatase binding site of Helicobacter pylori CagA protein and gastric atrophy and cancer
    Takeshi Azuma
    Second Department of Internal Medicine, Fukui Medical University, Fukui, Japan
    J Infect Dis 189:820-7. 2004
    ..pylori is associated with atrophic gastritis and gastric cancer and that persistent active inflammation induced by the East Asian CagA-positive strain may play a role in the pathogenesis of disease...
  5. ncbi Diversity of vacA and cagA genes of Helicobacter pylori in Japanese children
    T Azuma
    Second Department of Internal Medicine, Fukui Medical University, Fukui, Japan
    Aliment Pharmacol Ther 20:7-12. 2004
    ..Only a minority develops a clinical outcome even in childhood, such as peptic ulcer. It has been reported that H. pylori infection with the type I strain, which expresses the VacA and CagA antigen, is associated with peptic ulcer...
  6. ncbi The effect of Helicobacter pylori eradication therapy on dyspepsia symptoms in industrial workers in Japan
    T Azuma
    Second Department of Internal Medicine, Fukui Medical University, Fukui, Japan
    Aliment Pharmacol Ther 15:805-11. 2001
    ..The potential benefits and risks of the treatment could depend on local conditions, such as the prevalence of the infection and the local rates of gastric cancer...
  7. pmc Distinct diversity of the cag pathogenicity island among Helicobacter pylori strains in Japan
    Takeshi Azuma
    Second Department of Internal Medicine, Faculty of Medical Science, University of Fukui Matsuoka cho, Yoshida gun, Fukui 910 1193, Japan
    J Clin Microbiol 42:2508-17. 2004
    ..These results suggest that a distinct diversity of the cag PAI of H. pylori is present among Japanese strains and that this diversity may be involved in the development of atrophic gastritis and may increase the risk for gastric cancer...
  8. ncbi Pharmacokinetics of clarithromycin in Helicobacter pylori eradication therapy in patients with liver cirrhosis
    T Azuma
    Second Department of Internal Medicine, Faculty of Medicine, Fukui Medical University, Japan
    Aliment Pharmacol Ther 14:216-22. 2000
    ..However, the efficacy and the safety of this therapy in patients with liver cirrhosis have not been established...
  9. ncbi Correlation between variation of the 3' region of the cagA gene in Helicobacter pylori and disease outcome in Japan
    Takeshi Azuma
    Second Department of Internal Medicine, Fukui Medical University, Japan
    J Infect Dis 186:1621-30. 2002
    ..Although the cag PAI is conserved in H. pylori isolates in Japan, H. pylori infection with the cagA genotype with >4 R1 sequences may correlate with the pathogenesis of atrophic gastritis and gastric cancer...
  10. pmc Sequence analysis and clinical significance of the iceA gene from Helicobacter pylori strains in Japan
    Y Ito
    Second Department of Internal Medicine, Fukui Medical University, Fukui, Japan
    J Clin Microbiol 38:483-8. 2000
    ..We showed that iceA1 sequence variations may be useful tools for analysis of the population genetics of H. pylori...
  11. ncbi Effects of CYP2C19 gene polymorphism on cure rates for Helicobacter pylori infection by triple therapy with proton pump inhibitor (omeprazole or rabeprazole), amoxycillin and clarithromycin in Japan
    M Dojo
    Second Department of Internal Medicine, Fukui Medical University, Japan
    Dig Liver Dis 33:671-5. 2001
    ....
  12. ncbi Association of the HLA-DRB1 gene locus with gastric adenocarcinoma in Japan
    M Ohtani
    Second Department of Internal Medicine, Fukui Medical University, Matsuoka cho, Yoshida gun, Fukui 910 1193, Japan
    Dig Liver Dis 35:468-72. 2003
    ..The aim of the present study was to investigate host genetic factors that increase the risk of gastric adenocarcinoma among H. pylori-infected individuals...
  13. ncbi Full-length sequence analysis of the vacA gene from cytotoxic and noncytotoxic Helicobacter pylori
    Y Ito
    Second Department of Internal Medicine, Fukui Medical University, Japan
    J Infect Dis 178:1391-8. 1998
    ..The phylogenetic tree based on the vacA open-reading frame indicated that two different H. pylori lineages are circulating in Japan and the West...
  14. ncbi Bile reflux due to disturbed gastric movement is a cause of spontaneous gastric ulcer in W/Wv mice
    T Azuma
    Second Department of Internal Medicine, Faculty of Medicine, Fukui Medical University, Japan
    Dig Dis Sci 44:1177-83. 1999
    ..These results suggest that bile reflux due to the disturbance of gastric antral movement is a cause of the spontaneous gastric ulcers in W/Wv mice...
  15. pmc Analysis and typing of the vacA gene from cagA-positive strains of Helicobacter pylori isolated in Japan
    Y Ito
    Second Department of Internal Medicine, Fukui Medical School, Yoshida gun, Japan
    J Clin Microbiol 35:1710-4. 1997
    ..These results indicate that the cagA-positive, s1a/m1-type strains are common in Japan, regardless of the vacA phenotype or clinical outcome...
  16. ncbi Endoscopic [13C]-urea breath test for quantification of Helicobacter pylori infection
    H Suto
    Second Department of Internal Medicine, Faculty of Medicine, Fukui Medical University, Yoshida gun, Japan
    J Gastroenterol Hepatol 15:161-7. 2000
    ..We previously developed a new diagnostic method for Helicobacter pylori infection and called it the endoscopic [13C]-urea breath test (EUBT). Here we evaluate the relationship between the EUBT results and the histological findings...
  17. ncbi Evaluation of treatment for gastro-oesophageal reflux disease with a proton pump inhibitor, and relationship between gastro-oesophageal reflux disease and Helicobacter pylori infection in Japan
    A Muramatsu
    Second Department of Internal Medicine, Faculty of Medical Sciences, University of Fukui, Fukui, Japan
    Aliment Pharmacol Ther 20:102-6. 2004
    ..Effective therapy for gastro-oesophageal reflux disease (GERD) is associated with improvement in health-related quality of life. It remains unclear whether Helicobacter pylori infection protects against GERD...
  18. ncbi The CagA protein of Helicobacter pylori is translocated into epithelial cells and binds to SHP-2 in human gastric mucosa
    Shiho Yamazaki
    Second Department of Internal Medicine, Fukui Medical University, Japan
    J Infect Dis 187:334-7. 2003
    ..Deregulation of SHP-2 by CagA may play a role in the acquisition of a cellular-transformed phenotype at a relatively early stage of multistep gastric carcinogenesis...
  19. pmc Helicobacter pylori infection induces hyperammonaemia in Mongolian gerbils with liver cirrhosis
    H Suto
    Second Department of Internal Medicine, Faculty of Medicine, Fukui Medical University, Fukui, Japan
    Gut 48:605-8. 2001
    ..Systemic and portal blood ammonia levels in group D were significantly higher than those in the other groups. CONCLUSIONS: H pylori infection induces hyperammonaemia in gerbils with liver cirrhosis...
  20. ncbi EPIYA motif is a membrane-targeting signal of Helicobacter pylori virulence factor CagA in mammalian cells
    Hideaki Higashi
    Division of Molecular Oncology, Institute for Genetic Medicine, Hokkaido University, Sapporo, Japan
    J Biol Chem 280:23130-7. 2005
    ..pylori infection...
  21. pmc Biological activity of the Helicobacter pylori virulence factor CagA is determined by variation in the tyrosine phosphorylation sites
    Hideaki Higashi
    Division of Molecular Oncology, Institute for Genetic Medicine, Graduate School of Science, Hokkaido University, Sapporo 060 0815, Japan
    Proc Natl Acad Sci U S A 99:14428-33. 2002
    ..The presence of distinctly structured CagA proteins in Western and East Asian H. pylori isolates may underlie the strikingly different incidences of gastric carcinoma in these two geographic areas...
  22. ncbi SHP-2 tyrosine phosphatase as an intracellular target of Helicobacter pylori CagA protein
    Hideaki Higashi
    Division of Molecular Oncology, Institute for Genetic Medicine and Graduate School of Science, Hokkaido University, Sapporo 060 0815, Japan
    Science 295:683-6. 2002
    ..Conversely, the CagA effect on cells was reproduced by constitutively active SHP-2. Thus, upon translocation, CagA perturbs cellular functions by deregulating SHP-2...
  23. ncbi Clinical relevance of cagE gene from Helicobacter pylori strains in Japan
    Kanako Fukuta
    Third Department of Internal Medicine, Toyama Medical and Pharmaceutical University, Japan
    Dig Dis Sci 47:667-74. 2002
    ..In conclusion, the strains with cagE, cagA, and the s1c/ml genotype of vacA are predominant in Japan regardless of clinical outcome and construct a different phylogenetic cluster from those in the West...
  24. ncbi Helicobacter pylori CagA induces Ras-independent morphogenetic response through SHP-2 recruitment and activation
    Hideaki Higashi
    Division of Molecular Oncology, Institute for Genetic Medicine, Hokkaido University, Kita 15, Nishi 7, Kita ku, Sapporo 060 0815, Japan
    J Biol Chem 279:17205-16. 2004
    ..Our work therefore suggests a key role of SHP-2 in the pathological activity of H. pylori virulence factor CagA...
  25. ncbi Relationship between the diversity of the cagA gene of Helicobacter pylori and gastric cancer in Okinawa, Japan
    Satoko Satomi
    Second Department of Internal Medicine, Faculty of Medical Science, University of Fukui, Fukui, Japan
    J Gastroenterol 41:668-73. 2006
    ..The diversity of CagA, which collectively determines the binding affinity of CagA to SHP-2, may be an important variable in determining the clinical outcome of infection by different H. pylori strains...
  26. pmc Focal adhesion kinase is a substrate and downstream effector of SHP-2 complexed with Helicobacter pylori CagA
    Ryouhei Tsutsumi
    Division of Molecular Oncology, Institute for Genetic Medicine, Hokkaido University, Kita 15, Nishi 7, Sapporo 060 0815, Japan
    Mol Cell Biol 26:261-76. 2006
    ..Impaired cell adhesion and increased motility by CagA may be involved in the development of gastric lesions associated with cagA-positive H. pylori infection...
  27. ncbi Helicobacter pylori CagA protein variation associated with gastric cancer in Asia
    Takeshi Azuma
    Second Department of Internal Medicine, School of Medicine, Fukui University, 910 1193, Fukui, Matsuoka cho, Yoshida gun, Japan
    J Gastroenterol 39:97-103. 2004
    ....
  28. ncbi Helicobacter pylori CagA targets PAR1/MARK kinase to disrupt epithelial cell polarity
    Iraj Saadat
    Division of Molecular Oncology, Institute for Genetic Medicine, Graduate School of Science, Hokkaido University, Sapporo 060 0815, Japan
    Nature 447:330-3. 2007
    ..Our findings revealed that PAR1 is a key target of H. pylori CagA in the disorganization of gastric epithelial architecture underlying mucosal damage, inflammation and carcinogenesis...
  29. ncbi Structural basis and functional consequence of Helicobacter pylori CagA multimerization in cells
    Shumei Ren
    Division of Molecular Oncology, Institute for Genetic Medicine, Hokkaido University, Kita 15 Nishi 7, Kita ku, Sapporo 060 0815, Japan
    J Biol Chem 281:32344-52. 2006
    ..The present work raises the possibility that inhibition of CagA multimerization abolishes pathophysiological activities of CagA that promote gastric carcinogenesis...
  30. ncbi The diversity of vacA and cagA genes of Helicobacter pylori in East Asia
    Wen Zhou
    Second Department of Internal Medicine, Fukui Medical University, Matsuoka cho, Yoshida gun, Fukui 910 1193, Japan
    FEMS Immunol Med Microbiol 40:81-7. 2004
    ..These findings suggest that a distinct distribution of the vacA and cagA genotypes is present in East Asia, regardless of clinical outcome...
  31. ncbi [CagA of H. pylori and gastric mucosal damage]
    Takeshi Azuma
    Second Department of Internal Medicine, Fukui Medical University
    Nihon Rinsho 60:101-7. 2002
  32. ncbi Helicobacter pylori infection triggers aberrant expression of activation-induced cytidine deaminase in gastric epithelium
    Yuko Matsumoto
    Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, 54 Kawahara cho, Shogoin, Sakyo ku, Kyoto 606 8507, Japan
    Nat Med 13:470-6. 2007
    ..Our findings provide evidence that aberrant AID expression caused by H. pylori infection might be a mechanism of mutation accumulation in the gastric mucosa during H. pylori-associated gastric carcinogenesis...
  33. pmc Evolutionary dynamics of insertion sequences in Helicobacter pylori
    Awdhesh Kalia
    Department of Molecular Microbiology, Washington University School of Medicine, Saint Louis, Missouri, USA
    J Bacteriol 186:7508-20. 2004
    ..Taken together, similarities in IS elements and H. pylori population genetic structures and evidence of adaptive evolution in IS elements suggest that there is coevolution between these elements and their bacterial hosts...
  34. pmc Functional antagonism between Helicobacter pylori CagA and vacuolating toxin VacA in control of the NFAT signaling pathway in gastric epithelial cells
    Kazuyuki Yokoyama
    Institute for Genetic Medicine, Hokkaido University, Sapporo 060 0815, Japan
    Proc Natl Acad Sci U S A 102:9661-6. 2005
    ..pylori infection...
  35. ncbi Identification of Helicobacter pylori and the cagA genotype in gastric biopsies using highly sensitive real-time PCR as a new diagnostic tool
    Shiho Yamazaki
    Second Department of Internal Medicine, Faculty of Medical Sciences, University of Fukui, Matsuoka cho, Yoshida gun, Fukui 910 1193, Japan
    FEMS Immunol Med Microbiol 44:261-8. 2005
    ..3% (3/41) reacted with both types of cagA. These results suggest that this real-time PCR system provides a highly sensitive assessment of CagA type as a new diagnostic tool for the pathogenicity of H. pylori infection...
  36. ncbi Influence of EPIYA-repeat polymorphism on the phosphorylation-dependent biological activity of Helicobacter pylori CagA
    Masanori Naito
    Division of Molecular Oncology, Institute for Genetic Medicine, Hokkaido University, Sapporo, Japan
    Gastroenterology 130:1181-90. 2006
    ..Here we investigated the influence of EPIYA-repeat polymorphism on the CagA activity...
  37. pmc Enhanced expression of CCL20 in human Helicobacter pylori-associated gastritis
    Akira Yoshida
    Second Department of Internal Medicine, Nagasaki University School of Medicine, Sakamoto, Nagasaki 852 8501, Japan
    Clin Immunol 130:290-7. 2009
    ..The CCL20/CCR6 interaction may be involved in the development of H. pylori-associated gastritis...
  38. pmc Distinct diversity of vacA, cagA, and cagE genes of Helicobacter pylori associated with peptic ulcer in Japan
    Shiho Yamazaki
    Second Department of Internal Medicine, Faculty of Medical Sciences, University of Fukui, Fukui, Japan
    J Clin Microbiol 43:3906-16. 2005
    ..7%, 5/22) (chi2 = 12.64, P = 0.00057). These data suggest that the molecular genetics of vacA and cagPAI are associated and that the Western group with vacA and cagPAI genes is associated with peptic ulcer disease...
  39. ncbi Cytotoxicity and recognition of receptor-like protein tyrosine phosphatases, RPTPalpha and RPTPbeta, by Helicobacter pylori m2VacA
    Blanquita B De Guzman
    Department of Bacteriology, Institute of Tropical Medicine, Nagasaki University, Nagasaki 8528523, Japan
    Cell Microbiol 7:1285-93. 2005
    ..Different post-translational modifications of RPTPalpha in HeLa cells may be responsible for the reduced susceptibility to m2VacA...
  40. ncbi [Obesity after the cure of H. pylori infection]
    Takeshi Azuma
    Frontier Medical Science in Gastroenterology, International Center for Medical Research and Treatment, Kobe University School of Medicine
    Nihon Rinsho 63:531-5. 2005
  41. ncbi [An increase in body weight after eradication of Helicobacter pylori]
    Hiroyuki Suto
    Department of Endoscopic Medicine, Faculty of Medical Sciences, University of Fukui
    Nihon Shokakibyo Gakkai Zasshi 104:339-43. 2007
  42. ncbi East Asian-type Helicobacter pylori cytotoxin-associated gene A protein has a more significant effect on growth of rat gastric mucosal cells than the Western type
    Hai Ying Fu
    Department of Clinical Laboratory Science, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    J Gastroenterol Hepatol 22:355-62. 2007
    ..It is classified into two major subtypes, Western and East Asian. The present study aimed to compare the effects of East Asian-type and Western-type CagA on host cell growth...
  43. ncbi Rare Helicobacter pylori infection as a factor for the very low stomach cancer incidence in Yogyakarta, Indonesia
    Shinkan Tokudome
    Department of Health Promotion and Preventive Medicine, Nagoya City University Graduate School of Medical Sciences, Mizuho ku, Nagoya 467 8601, Japan
    Cancer Lett 219:57-61. 2005
    ..The very low incidence of stomach cancer in Yogyakarta may be due to a low prevalence of H. pylori infection and chronic atrophic gastritis...
  44. pmc Changing antimicrobial susceptibility epidemiology of Helicobacter pylori strains in Japan between 2002 and 2005
    Intetsu Kobayashi
    Chemotherapy Division, Mitsubishi Chemical Medience Corporation, Tokyo, Japan
    J Clin Microbiol 45:4006-10. 2007
    ..The development of an effective H. pylori eradication regimen in Japan will require continued resistance surveillance as well as a better understanding of the epidemiology of resistance...
  45. ncbi Meta-analysis of the relationship between CagA seropositivity and gastric cancer
    Takeshi Azuma
    Gastroenterology 126:1926-7; author reply 1927-8. 2004
  46. ncbi [A new problem after Helicobacter pylori eradication 'obesity']
    Hiroyuki Suto
    Second Department of Internal Medicine, Faculty of Medicine, Fukui Medical University
    Nihon Rinsho 60:765-8. 2002
  47. doi The effects of Helicobacter pylori eradication on body mass index and dyspeptic symptoms
    Hiroyuki Suto
    Department of Endoscopic Medicine, Faculty of Medical Sciences, University of Fukui, Yoshida gun, Fukui, Japan
    Digestion 79:235-42. 2009
    ..We investigated the changes in BMI and dyspeptic symptoms after H. pylori eradication among stages of atrophic gastritis classified according to the serum pepsinogen (PG) I/II ratio...
  48. ncbi [H. pylori infection and host's genetic analysis using HLA polymorphisms]
    Takeshi Azuma
    Second Department of Internal Medicine, Fukui Medical University
    Nihon Rinsho 60:184-9. 2002
  49. doi Asia-Pacific consensus guidelines on gastric cancer prevention
    Kwong Ming Fock
    Changi General Hospital, Singapore
    J Gastroenterol Hepatol 23:351-65. 2008
    ..Gastric cancer is a major health burden in the Asia-Pacific region but consensus on prevention strategies has been lacking. We aimed to critically evaluate strategies for preventing gastric cancer...
  50. ncbi Deregulation of beta-catenin signal by Helicobacter pylori CagA requires the CagA-multimerization sequence
    Yo Kurashima
    Division of Molecular Oncology, Institute for Genetic Medicine, Hokkaido University, Sapporo, Japan
    Int J Cancer 122:823-31. 2008
    ..Our results indicate that aberrant activation of the beta-catenin signal, which promotes precancerous intestinal metaplasia, is an inherent and fundamental CagA activity that is independent of the structural polymorphism of CagA...
  51. pmc Molecular characterization of Helicobacter pylori VacA induction of IL-8 in U937 cells reveals a prominent role for p38MAPK in activating transcription factor-2, cAMP response element binding protein, and NF-kappaB activation
    Junzo Hisatsune
    Department of Bacteriology, Institute of Tropical Medicine, Nagasaki University, Nagasaki, Japan
    J Immunol 180:5017-27. 2008
    ..Thus, in U937 cells, VacA directly increases IL-8 production by activation of the p38 MAPK via intracellular Ca(2+) release, leading to activation of the transcription factors, ATF-2, CREB, and NF-kappaB...
  52. pmc Transgenic expression of Helicobacter pylori CagA induces gastrointestinal and hematopoietic neoplasms in mouse
    Naomi Ohnishi
    Division of Molecular Oncology, Institute for Genetic Medicine, Graduate School of Science, Health Administration Center, Hokkaido University, Sapporo 060 0815, Japan
    Proc Natl Acad Sci U S A 105:1003-8. 2008
    ..pylori-associated neoplasms...
  53. ncbi Re: helicobacter pylori infection and gastric cancer: facing the enigmas
    Shinkan Tokudome
    Int J Cancer 112:166-7; author reply 168-9. 2004
  54. ncbi Variations in the core promoter/pre-core region in HBV genotype C in Japanese and Northern Vietnamese patients
    Bui Xuan Truong
    Kobe University Graduate School of Medicine, Clinical Molecular Medicine, Kobe, Japan
    J Med Virol 79:1293-304. 2007
    ..The subgenotypes and unique mutations of HBV genotype C in the Vietnamese and Japanese differed, and C/A1753 and C1858 variants might play a role in the pathogenesis of liver disease in Vietnamese patients...
  55. ncbi Helicobacter pylori-dependent NF-kappa B activation in newly established Mongolian gerbil gastric cancer cell lines
    Koji Nozaki
    Division of Oncological Pathology, Aichi Cancer Center Research Institute, 1 1 Kanokoden, Chikusa ku, Nagoya, Aichi 464 8681, Japan
    Cancer Sci 96:170-5. 2005
    ..pylori, and thus might greatly contribute to gastric cancer prevention and treatment in humans...
  56. ncbi Recurrent peptic ulcers in patients following successful Helicobacter pylori eradication: a multicenter study of 4940 patients
    Hiroto Miwa
    Department of Gastroenterology, Juntendo University School of Medicine, Tokyo, Japan
    Helicobacter 9:9-16. 2004
    ..The aim of this study is to describe the recurrence rate and specific features of peptic ulcers after cure of H. pylori infection...
  57. ncbi Late infantile Hirschsprung disease-mental retardation syndrome with a 3-bp deletion in ZFHX1B
    M Yoneda
    Second Department of Internal Medicine, Fukui Medical University, Fukui, Japan
    Neurology 59:1637-40. 2002
    ..This suggests that screening for ZFHX1B mutations is warranted even in the absence of typical clinical features of the syndrome...
  58. ncbi [Plaunotol]
    Shigeji Ito
    Division of Internal Medicine, Tannan Regional Medical Center
    Nihon Rinsho 60:693-7. 2002
  59. ncbi Prescription of nonsteroidal anti-inflammatory drugs and co-prescribed drugs for mucosal protection: analysis of the present status based on questionnaires obtained from orthopedists in Japan
    Hidetaka Tsumura
    Department of Gastroenterology, Kobe University School of Medicine
    Intern Med 46:927-31. 2007
    ..The aim of the present study was to examine factors influencing orthopedists in Japan in the use of cytoprotective drugs to prevent NSAID-associated gastrointestinal adverse events...
  60. pmc Hypoxia-inducible factor 1 alpha and vascular endothelial growth factor overexpression in ischemic colitis
    Tomoyuki Okuda
    Second Department of Internal Medicine, Faculty of Medical Sciences, University of Fukui, Matsuoka cho, Yoshida gun, Fukui 9101193, Japan
    World J Gastroenterol 11:1535-9. 2005
    ..To examine the etiology and pathophysiology in human ischemic colitis from the viewpoint of ischemic factors such as hypoxia-inducible factor 1 alpha (HIF-1 alpha and vascular endothelial growth factor (VEGF)...
  61. ncbi Gastric dysmotility associated with accumulation of mitochondrial A3243G mutation in the stomach
    Akihiro Fujii
    Second Department of Internal Medicine, Faculty of Medical Sciences, University of Fukui, Matsuoka, Fukui
    Intern Med 43:1126-30. 2004
    ..We analyzed the accumulation of a mitochondrial A-to-G mutation at nucleotide position 3243 (A3243G) in the stomach and gastric motility in patients with gastric symptoms, post-prandial nausea/vomiting and epigastralgia...
  62. ncbi Association between interleukin-1beta-511C/T polymorphism and reflux esophagitis in Japan
    Atsushi Muramatsu
    Second Department of Internal Medicine, Faculty of Medical Sciences, University of Fukui, Matsuoka cho, Yoshida gun, Fukui 910 1193, Japan
    J Gastroenterol 40:873-7. 2005
    ..However, little information is available about the genetic risk factors of reflux esophagitis. In this study we investigated its association with the IL-1beta polymorphisms...
  63. ncbi Anti-tumor effect of pegylated interferon in the rat hepatocarcinogenesis model
    Akira Miki
    Division of Molecular Medicine and Medical Genetics, International Center of Medical Research and Treatment, Kobe University Graduate School of Medicine, Kusunoki cho, Kobe 650 0017, Japan
    Int J Oncol 32:603-8. 2008
    ..The inhibitory effect of the PEG-IFN and IFN on hepatocarcinogenesis was almost the same, and this might be induced by the Fas-related apoptosis in the surrounding tissues...
  64. ncbi Dendritic cell vaccination for patients with chronic myelogenous leukemia
    Tsuyoshi Takahashi
    Department of Hematology and Oncology, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113, Japan
    Leuk Res 27:795-802. 2003
    ..The clinical benefits of bcr-abl peptide-specific vaccination in CML remain to be determined. Further vaccine development is necessary to increase the clinical effect...
  65. ncbi Cell kinetics of slow renewing cell populations in mice stomach
    Yasushi Magami
    Division of Gene Therapy, Intractable Disease Research Center, Tokyo Medical University, Tokyo, Japan
    J Gastroenterol Hepatol 17:262-9. 2002
    ..To examine cell renewal of these cells, continuous labeling with tritiated ([3H])-thymidine was performed...