Hideyuki Akaza

Summary

Affiliation: University of Tsukuba
Country: Japan

Publications

  1. doi request reprint Survival of metastatic germ cell cancer patients assessed by international germ cell consensus classification in Japan
    Ichiro Shintaku
    Department of Urology, Tohoku University Graduate School of Medicine, 1 1 Seiryo machi, Aoba ku, Sendai, Miyagi 980 8574, Japan
    Jpn J Clin Oncol 38:281-7. 2008
  2. ncbi request reprint [The possibility of S-1 for the treatment of patients with urological cancers]
    Hideyuki Akaza
    Dept of Urology, Institute of Clinical Medicine, University of Tsukuba, Japan
    Gan To Kagaku Ryoho 33:236-8. 2006
  3. ncbi request reprint Laminin expression patterns in human ureteral tissue
    Kazunori Hattori
    Department of Urology, University of Tsukuba, 1 1 1 Tennodai, Tsukuba, Ibaraki 305 8575, Japan
    J Urol 170:2040-3. 2003
  4. doi request reprint Clinical outcome of tumor recurrence for Ta, T1 non-muscle invasive bladder cancer from the data on registered bladder cancer patients in Japan: 1999-2001 report from the Japanese Urological Association
    Eiji Kikuchi
    Working Group of the Bladder Cancer Registration Committee of the Japanese Urological Association, Department of Urology, Keio University School of Medicine, Tokyo, Japan
    Int J Urol 16:279-86. 2009
  5. ncbi request reprint Treatment outcome of metastatic testicular cancer at a single institution in Japan, a country with low incidence of germ cell tumor
    Koji Kawai
    Department of Urology, Institute of Clinical Medicine, University of Tsukuba, Tsukuba City, Ibaraki 305, Japan
    Jpn J Clin Oncol 36:723-30. 2006
  6. ncbi request reprint Prediction of in vitro response to interferon-alpha in renal cell carcinoma cell lines
    Toru Shimazui
    Department of Urology, Institute of Clinical Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba1 1 1 Tennodai, Tsukuba, Ibaraki, 305 8575, Japan
    Cancer Sci 98:529-34. 2007
  7. ncbi request reprint The 3rd Conference on Asian Trends in Prostate Cancer Hormone Therapy
    Hideyuki Akaza
    Department of Urology, Institute of Clinical Medicine, University of Tsukuba, Ibaraki 305 8576, Japan
    Gan To Kagaku Ryoho 31:1285-95. 2004
  8. doi request reprint Analysis of Intravesical Recurrence After Bladder-preserving Therapy for Muscle-invasive Bladder Cancer
    Mizuki Onozawa
    Department of Urology, Faculty of Medicine, University of Tsukuba, Tsukuba City, Japan
    Jpn J Clin Oncol 42:825-30. 2012
  9. ncbi request reprint Current status of endocrine therapy for prostate cancer in Japan analysis of primary androgen deprivation therapy on the basis of data collected by J-CaP
    Shiro Hinotsu
    Urology and Andrology, Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1 1 1 Tennodai, Tsukuba City, Ibaraki Prefecture, 305 8575, Japan
    Jpn J Clin Oncol 37:775-81. 2007
  10. ncbi request reprint Radical prostatectomy and adjuvant endocrine therapy for prostate cancer with or without preoperative androgen deprivation: Five-year results
    Yukio Homma
    Department of Urology, University of Tokyo, Tokyo, Japan
    Int J Urol 11:295-303. 2004

Detail Information

Publications109 found, 100 shown here

  1. doi request reprint Survival of metastatic germ cell cancer patients assessed by international germ cell consensus classification in Japan
    Ichiro Shintaku
    Department of Urology, Tohoku University Graduate School of Medicine, 1 1 Seiryo machi, Aoba ku, Sendai, Miyagi 980 8574, Japan
    Jpn J Clin Oncol 38:281-7. 2008
    ..Since the IGCC classification was based on patients treated between 1975 and 1990, we aimed to investigate whether survival has improved for more recently treated Japanese patients...
  2. ncbi request reprint [The possibility of S-1 for the treatment of patients with urological cancers]
    Hideyuki Akaza
    Dept of Urology, Institute of Clinical Medicine, University of Tsukuba, Japan
    Gan To Kagaku Ryoho 33:236-8. 2006
    ..Two phase II trials are being conducted to evaluate the efficacy and safety of S-1 as a single agent therapy for patients with hormone-refractory prostate cancer (HRPC) and renal cell carcinoma (RCC)...
  3. ncbi request reprint Laminin expression patterns in human ureteral tissue
    Kazunori Hattori
    Department of Urology, University of Tsukuba, 1 1 1 Tennodai, Tsukuba, Ibaraki 305 8575, Japan
    J Urol 170:2040-3. 2003
    ..In this study we examined the expression patterns of the laminin chains in human ureteral tissue in vitro and in vivo...
  4. doi request reprint Clinical outcome of tumor recurrence for Ta, T1 non-muscle invasive bladder cancer from the data on registered bladder cancer patients in Japan: 1999-2001 report from the Japanese Urological Association
    Eiji Kikuchi
    Working Group of the Bladder Cancer Registration Committee of the Japanese Urological Association, Department of Urology, Keio University School of Medicine, Tokyo, Japan
    Int J Urol 16:279-86. 2009
    ....
  5. ncbi request reprint Treatment outcome of metastatic testicular cancer at a single institution in Japan, a country with low incidence of germ cell tumor
    Koji Kawai
    Department of Urology, Institute of Clinical Medicine, University of Tsukuba, Tsukuba City, Ibaraki 305, Japan
    Jpn J Clin Oncol 36:723-30. 2006
    ..Objectives of the present investigation are to evaluate outcome of a single institution in Japan, and to identify prognostic factors for testicular cancer...
  6. ncbi request reprint Prediction of in vitro response to interferon-alpha in renal cell carcinoma cell lines
    Toru Shimazui
    Department of Urology, Institute of Clinical Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba1 1 1 Tennodai, Tsukuba, Ibaraki, 305 8575, Japan
    Cancer Sci 98:529-34. 2007
    ..Furthermore, the IFNalpha response to RCC might be modulated by regulation of the expression level of these molecules...
  7. ncbi request reprint The 3rd Conference on Asian Trends in Prostate Cancer Hormone Therapy
    Hideyuki Akaza
    Department of Urology, Institute of Clinical Medicine, University of Tsukuba, Ibaraki 305 8576, Japan
    Gan To Kagaku Ryoho 31:1285-95. 2004
    ....
  8. doi request reprint Analysis of Intravesical Recurrence After Bladder-preserving Therapy for Muscle-invasive Bladder Cancer
    Mizuki Onozawa
    Department of Urology, Faculty of Medicine, University of Tsukuba, Tsukuba City, Japan
    Jpn J Clin Oncol 42:825-30. 2012
    ..The aim of the present study was to analyze the pattern of recurrences after bladder-preserving therapy for muscle-invasive bladder cancer...
  9. ncbi request reprint Current status of endocrine therapy for prostate cancer in Japan analysis of primary androgen deprivation therapy on the basis of data collected by J-CaP
    Shiro Hinotsu
    Urology and Andrology, Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1 1 1 Tennodai, Tsukuba City, Ibaraki Prefecture, 305 8575, Japan
    Jpn J Clin Oncol 37:775-81. 2007
    ....
  10. ncbi request reprint Radical prostatectomy and adjuvant endocrine therapy for prostate cancer with or without preoperative androgen deprivation: Five-year results
    Yukio Homma
    Department of Urology, University of Tokyo, Tokyo, Japan
    Int J Urol 11:295-303. 2004
    ..The effects of preoperative androgen deprivation on the outcomes of prostate cancer patients who received radical prostatectomy and subsequent adjuvant endocrine therapy have not yet been fully evaluated...
  11. ncbi request reprint A case of metastatic testicular cancer complicated by tumour lysis syndrome and choriocarcinoma syndrome
    Koji Kawai
    Department of Urology, Institute of Clinical Medicine, University of Tsukuba Graduate School of Comprehensive Human Sciences, Tsukuba City, Ibaraki, Japan
    Jpn J Clin Oncol 36:665-7. 2006
    ..The urological oncologist should be aware of the potential complications TLS and choriocarcinoma syndrome in cases of rapidly progressive and high-volume choriocarcinoma...
  12. doi request reprint Combined androgen blockade with bicalutamide for advanced prostate cancer: long-term follow-up of a phase 3, double-blind, randomized study for survival
    Hideyuki Akaza
    Department of Urology, Institute of Clinical Medicine, University of Tsukuba, Ibaraki, Japan
    Cancer 115:3437-45. 2009
    ..4 years indicated that CAB significantly (P<.001) prolonged the time to progression and the time to treatment failure. In the current report, survival data from a long-term follow-up (median, 5.2 years) were analyzed...
  13. doi request reprint Efficacy of S-1 in patients with castration-resistant prostate cancer: a phase II study
    Hideyuki Akaza
    Department of Urology and Andrology, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Japan
    Oncology 78:323-8. 2010
    ..The primary endpoint was prostate-specific antigen (PSA) response...
  14. doi request reprint Overall survival and updated results from a phase II study of sunitinib in Japanese patients with metastatic renal cell carcinoma
    Yoshihiko Tomita
    Department of Urology, Yamagata University School of Medicine, Yamagata, Japan
    Jpn J Clin Oncol 40:1166-72. 2010
    ..In a phase II, open-label, multicentre Japanese study, sunitinib demonstrated antitumour activity and acceptable tolerability in metastatic renal cell carcinoma patients. Final survival analyses and updated results are reported...
  15. ncbi request reprint Three-weekly docetaxel with prednisone is feasible for Japanese patients with hormone-refractory prostate cancer: a retrospective comparative study with weekly docetaxel alone
    Toru Shimazui
    Department of Urology, Institute of Clinical Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan
    Jpn J Clin Oncol 37:603-8. 2007
    ..Here, we compare it with the regimen of docetaxel once every 3 weeks (q3w) plus daily prednisone (PSL) based on a TAX 327 trial in order to clarify the efficacy and toxicity of docetaxel regimens in Japan...
  16. ncbi request reprint Completion and toxicity of induction chemotherapy for metastatic testicular cancer: an updated evaluation of Japanese patients
    Koji Kawai
    Department of Urology, University of Tsukuba, Ibaraki 305, Japan
    Jpn J Clin Oncol 36:425-31. 2006
    ..Therefore, we re-evaluated the completion and toxicity of BEP combined with modern supportive care...
  17. doi request reprint FOXO1 and TCF7L2 genes involved in metastasis and poor prognosis in clear cell renal cell carcinoma
    Takahiro Kojima
    Department of Urology, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Japan
    Genes Chromosomes Cancer 49:379-89. 2010
    ..We conclude that FOXO1 and TCF7L2 are involved in metastasis and that molecules in these signaling pathways may be targets for diagnostic procedures and therapies for CRCC...
  18. ncbi request reprint Background Variables for the Patients with Invasive Bladder Cancer Suitable for Bladder-preserving Therapy
    Naoto Miyanaga
    Department of Urology, Institute of Clinical Medicine, University of Tsukuba, 1 1 1 Tennoudai, Tsukuba City, Ibaraki 305 8575, Japan
    Jpn J Clin Oncol 37:852-7. 2007
    ..The present study was undertaken to identify the patients suitable for bladder preservation by analysis of our data...
  19. ncbi request reprint Weekly administration of docetaxel in patients with hormone-refractory prostate cancer: a pilot study on Japanese patients
    Takahiro Kojima
    Department of Urology, Institute of Clinical Medicine, University of Tsukuba, 2 1 1 Amakubo, Tsukuba City, Ibaraki 305 8576, Japan
    Jpn J Clin Oncol 34:137-41. 2004
    ..The purpose of this study was the investigation of the efficacy of docetaxel for Japanese patients with HRPC...
  20. ncbi request reprint Comparisons of percent equol producers between prostate cancer patients and controls: case-controlled studies of isoflavones in Japanese, Korean and American residents
    Hideyuki Akaza
    Department of Urology, University of Tsukuba, Tsukuba, Ibaraki, Japan
    Jpn J Clin Oncol 34:86-9. 2004
    ....
  21. ncbi request reprint The level of cadherin-6 mRNA in peripheral blood is associated with the site of metastasis and with the subsequent occurrence of metastases in renal cell carcinoma
    Toru Shimazui
    Department of Urology, Institute of Clinical Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba City, Ibaraki, Japan
    Cancer 101:963-8. 2004
    ....
  22. doi request reprint Age at diagnosis on prostate cancer survival undergoing androgen deprivation therapy as primary treatment in daily practice: results from Japanese observational cohort
    Teruo Inamoto
    Department of Urology, Osaka Medical College, 2 7 Daigaku machi, Takatsuki City, Osaka, 569 8686, Japan
    J Cancer Res Clin Oncol 140:1197-204. 2014
    ..To illustrate the consequence of PADT from daily clinical practice, we evaluated the relationship among age, disease risk, and survival of patients with prostate cancer treated by PADT in largest Asian cohort...
  23. doi request reprint Successful outcomes using combination therapy of interleukin-2 and interferon-alpha for renal cell carcinoma patients with lung metastasis
    Hideyuki Akaza
    Department of Urology and Andrology, Graduate School of Comprehensive Human Science, University of Tsukuba, Tsukuba, Ibaragi, Japan
    Jpn J Clin Oncol 40:684-9. 2010
    ..In this paper, the clinical response to our combination therapy is reported...
  24. doi request reprint Negative impact of metabolic syndrome on the responsiveness to sildenafil in Japanese men
    Takahiro Suetomi
    Department of Urology, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Japan
    J Sex Med 5:1443-50. 2008
    ..Several recent studies suggested that the prevalence of erectile dysfunction (ED) was higher in men with metabolic syndrome (MS)...
  25. ncbi request reprint Association of HER-2 polymorphism with Japanese sporadic prostate cancer susceptibility
    Akira Yokomizo
    Department of Urology, Graduate School of Medical Science, Kyushu University, Fukuoka 812 8582, Japan
    Prostate 62:49-53. 2005
    ..To determine the association of the HER-2 gene with Japanese sporadic Pca, we analyzed the frequency of codon 655 (A/G, isoleucine, or valine) in case and control group...
  26. ncbi request reprint The limited efficacy of methotrexate, actinomycin D and cisplatin (MAP) for patients with advanced testicular cancer
    Jun Miyazaki
    Department of Urology, Institute of Clinical Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan
    Jpn J Clin Oncol 33:391-5. 2003
    ..Combination chemotherapy of methotrexate, actinomycin D and cisplatin (MAP) is reported to be effective against gestational choriocarcinoma...
  27. ncbi request reprint Lectin-reactive alpha-fetoprotein as a marker for testicular tumor activity
    Koji Kawai
    University of Tsukuba, Institute of Clinical Medicine, Department of Urology, Tsukuba, Ibaraki, Japan
    Int J Urol 12:284-9. 2005
    ..In the present study, we used the subfraction profile of LCA-binding AFP to diagnose and monitor testicular tumor activity...
  28. doi request reprint A case of metastatic testicular cancer complicated by pulmonary hemorrhage due to choriocarcinoma syndrome
    Shuya Kandori
    Department of Urology, Institute of Clinical Medicine, University of Tsukuba Graduate School of Comprehensive Human Sciences, 1 1 1 Tennodai, Tsukuba, Ibaraki 305, Japan
    Int J Clin Oncol 15:611-4. 2010
    ....
  29. doi request reprint Gleason score correlation between biopsy and prostatectomy specimens and prediction of high-grade Gleason patterns: significance of central pathologic review
    Kentaro Kuroiwa
    Department of Urology, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan
    Urology 77:407-11. 2011
    ..A discrepancy in the GS between the biopsy and RP specimens has been reported...
  30. doi request reprint Validation of Partin tables and development of a preoperative nomogram for Japanese patients with clinically localized prostate cancer using 2005 International Society of Urological Pathology consensus on Gleason grading: data from the Clinicopathological
    Seiji Naito
    Department of Urology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    J Urol 180:904-9; discussion 909-10. 2008
    ..We validated the 2001 Partin tables and developed an original nomogram for Japanese patients using the 2005 International Society of Urological Pathology consensus on Gleason grading...
  31. doi request reprint An early phase II trial of S-1 in Japanese patients with cytokine-refractory metastatic renal cell carcinoma
    Seiji Naito
    Department of Urology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Cancer Chemother Pharmacol 66:1065-70. 2010
    ..4:1. The aim of this trial was to investigate the efficacy and safety of S-1 in Japanese patients with cytokine-refractory metastatic renal cell carcinoma (RCC)...
  32. doi request reprint Low expression of microphthalmia-associated transcription factor, a potential molecular target for interferon-alpha susceptibility, is associated with metastasis in renal cell carcinoma
    Toru Shimazui
    Department of Urology, Institute of Clinical Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Japan
    Cancer Sci 100:1714-8. 2009
    ..Quantification of MITF mRNA expression might be clinically useful to predict metastasis and survival of patients with RCC...
  33. ncbi request reprint Efficacy of primary hormone therapy for localized or locally advanced prostate cancer: results of a 10-year follow-up
    Hideyuki Akaza
    Department of Urology, Institute of Clinical Medicine, University of Tsukuba, Tsukuba, Japan
    BJU Int 98:573-9. 2006
    ....
  34. ncbi request reprint Does tumor size or microvascular invasion affect prognosis in patients with renal cell carcinoma?
    Tomoaki Miyagawa
    Department of Urology, Kitaibaraki Municipal General Hospital, Kitaibaraki, Ibaraki, Japan
    Jpn J Clin Oncol 37:197-200. 2007
    ..We retrospectively evaluated the effects of tumor size and microvascular tumor invasion on the clinical outcomes of patients who had undergone radical nephrectomy for renal cell carcinoma (RCC)...
  35. ncbi request reprint The case for androgen deprivation as primary therapy for early stage disease: results from J-CaP and CaPSURE
    Hideyuki Akaza
    Department of Urology, Institute of Clinical Medicine, University of Tsukuba, Tennodai 1 1 1, Tsukuba, Ibaraki 305 8578, Japan
    J Urol 176:S47-9. 2006
    ....
  36. doi request reprint A phase II study of sunitinib in Japanese patients with metastatic renal cell carcinoma: insights into the treatment, efficacy and safety
    Hirotsugu Uemura
    Department of Urology, University of Tsukuba, Graduate School of Comprehensive Human Sciences, Tsukuba 305 8576, Japan
    Jpn J Clin Oncol 40:194-202. 2010
    ..This study aims to assess the efficacy and safety of sunitinib in Japanese patients with metastatic renal cell carcinoma (RCC)...
  37. doi request reprint Prolonged treatment with three-weekly docetaxel plus daily prednisolone for metastatic castration-resistant prostate cancer: a multicenter, phase II, open-label, non-comparative, extension study in Japan
    Kazuo Nishimura
    Department of Urology, Osaka Medical Center for Cancer and Cardiovascular Diseases, 1 3 3 Nakamichi, Higashinari ku, Osaka, 537 8511, Japan
    Int J Clin Oncol 18:306-13. 2013
    ..Therefore, this study, ARD6563, was conducted to evaluate the safety of more than ten cycles of docetaxel in metastatic CRPC...
  38. ncbi request reprint The 5th Conference on Asian Trends in Prostate Cancer Hormone Therapy
    Hideyuki Akaza
    Institute of Clinical Medicine, University of Tsukuba, Japan
    Asian Pac J Cancer Prev 8:3-12. 2007
    ..Prednisone and dexamethasone are used for secondary hormonal therapy. External beam radiotherapy, radioisotopic drugs such as strontium 89, and bisphosphonates are common choices to control bone pain...
  39. doi request reprint Bladder cancer develops 6 years earlier in current smokers: analysis of bladder cancer registry data collected by the cancer registration committee of the Japanese Urological Association
    Shiro Hinotsu
    Urology and Andrology, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan
    Int J Urol 16:64-9. 2009
    ..The present study was undertaken to examine the relationships between smoking history of bladder cancer patients and the age of onset of bladder cancer and tumor characteristics...
  40. doi request reprint Pattern of intravesical recurrence after surgical treatment for urothelial cancer of the upper urinary tract: a single institutional retrospective long-term follow-up study
    Ei Ichiro Takaoka
    Department of Urology, Institute of Clinical Medicine University of Tsukuba, Tsukuba, Ibaraki, Japan
    Int J Urol 17:623-8. 2010
    ..To estimate the risk of intravesical recurrence in patients with primary urothelial cancer of the upper urinary tract...
  41. ncbi request reprint The therapeutic effects of R8-liposome-BCG-CWS on BBN-induced rat urinary bladder carcinoma
    Jun Miyazaki
    Graduate School of Comprehensive Human Sciences, Department of Urology, University of Tsukuba, Tsukuba, Ibaraki, 3058575 Japan
    Anticancer Res 31:2065-71. 2011
    ..We investigated the suppressive effect of liposome-incorporating cell wall skeleton (BCG-CWS) on N-butyl-N-(4-hydroxybutyl) nitrosamine (BBN)-induced urinary bladder carcinogenesis in rats...
  42. doi request reprint The liposome-incorporating cell wall skeleton of Mycobacterium bovis bacillus Calmette-Guéin can directly enhance the susceptibility of cancer cells to lymphokine-activated killer cells through up-regulation of natural-killer group 2, member D ligands
    Jun Miyazaki
    Graduate School of Comprehensive Human Sciences, Department of Urology, University of Tsukuba, Ibaraki, Japan
    BJU Int 108:1520-6. 2011
    ....
  43. ncbi request reprint Proton beam therapy for invasive bladder cancer: a prospective study of bladder-preserving therapy with combined radiotherapy and intra-arterial chemotherapy
    Masaharu Hata
    Proton Medical Research Center, University of Tsukuba, Tsukuba, Ibaraki, Japan
    Int J Radiat Oncol Biol Phys 64:1371-9. 2006
    ..To present outcomes of bladder-preserving therapy with proton beam irradiation in patients with invasive bladder cancer...
  44. ncbi request reprint Nrf2 and p53 cooperatively protect against BBN-induced urinary bladder carcinogenesis
    Katsuyuki Iida
    Department of Urology, Institute of Clinical Medicine, University of Tsukuba, Tennoudai 1 1 1, Tsukuba, Ibaraki 305 8577, Japan
    Carcinogenesis 28:2398-403. 2007
    ..These results thus reveal potential interactions between p53 and Nrf2 and their gene batteries, and indicate that both factors cooperatively contribute to tumor prevention...
  45. ncbi request reprint [Neoadjuvant chemotherapy in muscle-invasive bladder cancer]
    Naoto Miyanaga
    Dept of Urology, Institute of Clinical Medicine, University of Tsukuba, Ibaraki, Japan
    Gan To Kagaku Ryoho 34:1745-9. 2007
    ..Bladder preservation in selected patients on the basis of response to neoadjuvant chemotherapy is a feasible approach. The goal now must be to find more effective drugs and to better predict the individual response to therapy...
  46. ncbi request reprint Global update on defining and treating high-risk localized prostate cancer with leuprorelin: a Japanese perspective--the effect of primary androgen deprivation therapy on stage C prostate cancer
    Hideyuki Akaza
    Department of Urology, University of Tsukuba, Ibaraki, Japan
    BJU Int 99:10-2; discussion 17-8. 2007
    ....
  47. ncbi request reprint Characteristics of patients with prostate cancer who have initially been treated by hormone therapy in Japan: J-CaP surveillance
    Hideyuki Akaza
    Department of Urology, University of Tsukuba, Tsukuba, Ibaraki, Japan
    Jpn J Clin Oncol 34:329-36. 2004
    ..Hormone therapy for prostate cancer has empirically prevailed in Japan. We planned to evaluate the trends and outcome of hormone therapy for establishing an adequate guideline...
  48. doi request reprint Current status of chemotherapy in risk-adapted management for metastatic testicular germ cell cancer
    Koji Kawai
    Department of Urology, Institute of Clinical Medicine, University of Tsukuba Graduate School of Comprehensive Human Sciences, Tsukuba, Ibaraki, Japan
    Cancer Sci 101:22-8. 2010
    ..Along with the progress in chemotherapy, the risk-adapted management at experienced hospitals seems to be responsible for the recent progress in treatment outcome...
  49. ncbi request reprint Long-term results of first-line sequential high-dose carboplatin, etoposide and ifosfamide chemotherapy with peripheral blood stem cell support for patients with advanced testicular germ cell tumor
    Tsuneharu Miki
    Department of Urology, Kyoto Prefectural University of Medicine, Graduate School of Medical Sciences, Kyoto, Japan
    Int J Urol 14:54-9. 2007
    ..High-dose carboplatin, etoposide, ifosfamide chemotherapy followed by autologous peripheral blood stem cell transplantation (PBSCT) was investigated as first-line chemotherapy in patients with advanced testicular GCT...
  50. doi request reprint Final results of a phase II study of S-1 in patients with cytokine-refractory metastatic renal cell carcinoma
    Seiji Naito
    Department of Urology, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Jpn J Clin Oncol 44:122-6. 2014
    ..Here, we report the results of the final analysis assessing the efficacy and safety of S-1 including overall survival...
  51. ncbi request reprint A low-dose combination therapy of interleukin-2 and interferon-alpha is effective for lung metastasis of renal cell carcinoma: a multicenter open study
    Hideyuki Akaza
    Department of Urology, Institute of Clinical Medicine, University of Tsukuba, 2 1 1 Amakubo, Tsukuba 305 0005, Japan
    Int J Clin Oncol 11:434-40. 2006
    ..Efficacy and safety at this dose was evaluated (phase 2)...
  52. doi request reprint Overall survival and good tolerability of long-term use of sorafenib after cytokine treatment: final results of a phase II trial of sorafenib in Japanese patients with metastatic renal cell carcinoma
    Seiji Naito
    Department of Urology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    BJU Int 108:1813-9. 2011
    ..4% because of 6 late responders achieved after 9.2 months or longer of SD period; (3) lack of either unknown adverse events nor cumulative toxicity in the long-term use of sorafenib...
  53. doi request reprint Prostate cancer chemoprevention study: an investigative randomized control study using purified isoflavones in men with rising prostate-specific antigen
    Naoto Miyanaga
    Department of Urology and Andrology, Graduate School of Comprehensive Human Science, University of Tsukuba, Tsukuba, Japan
    Cancer Sci 103:125-30. 2012
    ..Registered with the UMIN Clinical Trials Registry (UMIN-CTR) for clinical trials in Japan (C000000446)...
  54. ncbi request reprint Tissue elasticity imaging for diagnosis of prostate cancer: a preliminary report
    Naoto Miyanaga
    Department of Urology, Graduate School of Comprehensive Human Sciences, Tsukuba, Japan
    Int J Urol 13:1514-8. 2006
    ..It is expected to become a new diagnostic modality for prostate cancer. The aim of this study was to examine the usefulness of elastography in the diagnosis of prostate cancer...
  55. ncbi request reprint Efficacy and safety of gemcitabine monotherapy in patients with transitional cell carcinoma after Cisplatin-containing therapy: a Japanese experience
    Hideyuki Akaza
    Department of Urology, Institute of Clinical Medicine, University of Tsukuba, Tsukuba City, Ibaraki, Japan
    Jpn J Clin Oncol 37:201-6. 2007
    ..However, a second-line therapy is still required for patients with recurrent TCC who discontinued MVAC because of toxicity or have MVAC refractory tumors...
  56. ncbi request reprint Superior anti-tumor efficacy of bicalutamide 80 mg in combination with a luteinizing hormone-releasing hormone (LHRH) agonist versus LHRH agonist monotherapy as first-line treatment for advanced prostate cancer: interim results of a randomized study in Ja
    Hideyuki Akaza
    Department of Urology, Institute of Clinical Medicine, University of Tsukuba, Tsukuba City, Ibaraki, Japan
    Jpn J Clin Oncol 34:20-8. 2004
    ..To evaluate bicalutamide (Casodex) 80 mg as a component of maximum androgen blockade (MAB) in Japanese patients with previously untreated advanced prostate cancer...
  57. ncbi request reprint Endocrine therapy with or without radical prostatectomy for T1b-T3N0M0 prostate cancer
    Yukio Homma
    Department of Urology, University of Tokyo, Tokyo, Japan
    Int J Urol 11:218-24. 2004
    ..We retrospectively compared the 5-year survival rates of T1b-T3N0M0 prostate cancer patients treated either by endocrine therapy plus radical prostatectomy or endocrine therapy alone...
  58. ncbi request reprint Prospective randomized trial of natural interferon-alpha versus natural interferon-alpha plus cimetidine in advanced renal cell carcinoma with pulmonary metastasis
    Toshiaki Kinouchi
    Department of Urology, Osaka Medical Center for Cancer and Cardiovascular Diseases, 1 3 3 Nakamichi, Higashinari ku, Osaka, 537 8511, Japan
    J Cancer Res Clin Oncol 132:499-504. 2006
    ....
  59. ncbi request reprint Higher consumption of green tea may enhance equol production
    Naoto Miyanaga
    Department of Urology, Post Graduate University of Tsukuba, Ibaraki, 305 8575, Japan
    Asian Pac J Cancer Prev 4:297-301. 2003
    ..In the present study, we examined relationships between type of food intake and the capacity for equol production in Japanese subjects...
  60. ncbi request reprint Persistence of prostatic intraepithelial neoplasia after effective chemoprevention of microscopic prostate cancer with antiandrogen in a rat model
    Atsushi Yamauchi
    Department of Urology, Institute of Clinical Medicine, University of Tsukuba, Tsukuba City, Ibaraki, Japan
    J Urol 175:348-52. 2006
    ..In the current study we determined whether antiandrogen would promote or suppress the prostate carcinogenesis when administration was begun at a later period of carcinogenesis...
  61. doi request reprint Extremely acute exacerbation of interstitial pneumonia after interferon-alpha treatment for metastatic renal cell carcinoma
    Satoshi Ando
    Graduate School of Comprehensive Human Sciences, Institute of Clinical Medicine, Department of Urology, University of Tsukuba, Tsukuba, Ibaraki, Japan
    Int J Clin Oncol 14:171-3. 2009
    ..Urologists should be aware of this complication in the treatment of renal cell carcinoma patients who have a prior history of interstitial pneumonia...
  62. ncbi request reprint Sustained prophylactic effect of intravesical bacille Calmette-Guérin for superficial bladder cancer: a smoothed hazard analysis in a randomized prospective study
    Shiro Hinotsu
    Department of Urology, Institute of Clinical Medicine, University of Tsukuba, Ibaraki, Japan
    Urology 67:545-9. 2006
    ..To ascertain the sustained prophylactic effect of intravesical bacille Calmette-Guérin (BCG) after transurethral resection of bladder tumor (TURBT), we compared the estimation of the duration of the effect with that of doxorubicin...
  63. ncbi request reprint Antineoplastic activity of honey in an experimental bladder cancer implantation model: in vivo and in vitro studies
    Tarek Swellam
    Department of Urology, Institute of Clinical Medicine, University of Tsukuba, 1 1 1 Tennodai, Tsukuba, Ibaraki 305 8575, Japan
    Int J Urol 10:213-9. 2003
    ..In the in vivo study, cancer cells were implanted subcutaneously in the abdomens of mice, and the effects were assessed by the tumor growth...
  64. doi request reprint Real-time elastography for the diagnosis of prostate cancer: evaluation of elastographic moving images
    Tomoaki Miyagawa
    Department of Urology, Kitaibaraki Municipal General Hospital, 4 5 15 Ohtsu cho, Kita cho, Kita Ibaraki City, Ibaraki, Japan
    Jpn J Clin Oncol 39:394-8. 2009
    ..Elastography is a technique for detecting the stiffness of tissues. We applied elastography for the diagnosis of prostate cancer and evaluated the usefulness of elastography for prostate biopsy...
  65. doi request reprint Cavernous hemangioma mimicking a cystic renal cell carcinoma
    Ei Ichiro Takaoka
    Department of Urology, Institute of Clinical Medicine, 1 1 1 Tennodai, Tsukuba, Ibaragi, 305 8575, Japan
    Int J Clin Oncol 13:166-8. 2008
    ..When we find a renal cyst with a solid component, renal cavernous hemangioma arising from the cyst wall should be considered in the differential diagnosis, and a conservative surgical approach should be considered...
  66. ncbi request reprint Identification of a type III secretion system in uropathogenic Escherichia coli
    Jun Miyazaki
    Department of Infection Biology, Institute of Basic Medical Sciences, University of Tsukuba, 1 1 1 Tennodai, Tsukuba shi, Ibaraki 305 8575, Japan
    FEMS Microbiol Lett 212:221-8. 2002
    ..coli K-12 MG1655. This finding suggested that the type III secretion system could play a part in uropathogenicity of UPEC...
  67. doi request reprint Maintenance intravesical bacillus Calmette-Guérin instillation for Ta, T1 cancer and carcinoma in situ of the bladder: randomized controlled trial by the BCG Tokyo Strain Study Group
    Hirofumi Koga
    Department of Urology, Graduate School of Medical Sciences, Kyushu University, Higashi ku, Fukuoka, Japan
    Int J Urol 17:759-66. 2010
    ....
  68. ncbi request reprint The 2nd conference on Asian trends in prostate cancer hormone therapy
    Hideyuki Akaza
    Department of Urology, Institute of Clinical Medicine, University of Tsukuba, Ibaraki 305 8576, Japan
    Gan To Kagaku Ryoho 30:1533-42. 2003
    ..quot; This session included 2 lively discussions, on whether Asian physicians can apply Western clinical data to Asian patients, and the need for Asian clinical data and developing clinical trials in the region, respectively...
  69. doi request reprint Immunoprotection against murine bladder carcinoma by octaarginine-modified liposomes incorporating cell wall of Mycobacterium bovis bacillus Calmette-Guérin
    Akira Joraku
    Graduate School of Comprehensive Human Sciences, Department of Urology, University of Tsukuba, Tsukuba, Ibaraki, Japan
    BJU Int 103:686-93. 2009
    ....
  70. doi request reprint Evidence-based clinical practice guidelines for renal cell carcinoma (Summary--JUA 2007 Edition)
    Tomoaki Fujioka
    Department of Urology, Iwate Medical University School of Medicine, Morioka, Iwate, Japan
    Int J Urol 16:339-53. 2009
    ..An abridged edition of these guidelines can be found on the web pages of the Japan Society of Clinical Oncology and the Medical Information Network Distribution Service...
  71. ncbi request reprint Phase II study to investigate the efficacy, safety, and pharmacokinetics of sorafenib in Japanese patients with advanced renal cell carcinoma
    Hideyuki Akaza
    Department of Urology and Andrology, Graduate School of Comprehensive Human Science, University of Tsukuba, Tsukuba 305 8576, Japan
    Jpn J Clin Oncol 37:755-62. 2007
    ..This phase II study investigated efficacy, safety, and pharmacokinetics of sorafenib in Japanese patients with advanced renal cell carcinoma (RCC)...
  72. ncbi request reprint Case of alpha-fetoprotein-producing transitional cell carcinoma of the renal pelvis
    Yoshiyuki Shiga
    Department of Urology, Institute of Clinical Medicine, University of Tsukuba, Ibaraki, Japan
    Int J Urol 11:117-8. 2004
    ..To our knowledge, this has not been reported previously. We present the first case of an alpha-fetoprotein-producing transitional cell carcinoma of the renal pelvis in a 70-year-old female...
  73. ncbi request reprint Effectiveness of Maximal Androgen Blockade (MAB): illusion or reality?
    Hideyuki Akaza
    Department of Urology, Institute of Clinical Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan
    Can J Urol 12:77-80. 2005
    ..Having said that, fundamental research and clinical trials in recent years do indicate that the benefit of MAB is not merely an illusion...
  74. ncbi request reprint [Significance of current bio- and molecular-markers in urological cancers]
    Toru Shimazui
    Department of Urology, Institute of Clinical Medicine, University of Tsukuba, 1 1 1 Tennoudai, Tsukuba, Ibaraki 305 8575, Japan
    Gan To Kagaku Ryoho 31:1008-14. 2004
    ..In renal cell carcinoma (RCC), unfortunately, no definitive biomarker is available for its diagnosis and monitoring. Thus, we must find new specific bio- and molecular-markers that reflect the biological activity of RCC...
  75. ncbi request reprint [Future prospects for primary hormone therapy in localized and locally advanced prostate cancer]
    Hideyuki Akaza
    Department of Urology, Institute of Clinical Medicine, University of Tsukuba
    Hinyokika Kiyo 49:771-7. 2003
    ....
  76. ncbi request reprint Neutropenic colitis during standard dose combination chemotherapy with nedaplatin and irinotecan for testicular cancer
    Ei Ichiro Takaoka
    Department of Urology, Institute of Clinical Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan
    Jpn J Clin Oncol 36:60-3. 2006
    ..The mortality rate is as high as 21-48% according to a recent review. The present case indicates that the neutropenic colitis can occur under neutropenic conditions induced by the standard-dose chemotherapy for solid cancer...
  77. ncbi request reprint Gene expression profiles correlate with the morphology and metastasis characteristics of renal cell carcinoma cells
    Yoshihiro Ami
    Department of Biochemistry and Molecular Oncology, Comprehensive Human Science, Graduate School, University of Tsukuba, Ibaraki 305 8573, Japan
    Oncol Rep 13:75-80. 2005
    ..The unique profiling pattern of gene expression clearly correlated with cell morphology and metastatic potential. Such profiling might contribute to identifying the genes involved in the clinical characteristics of RCC...
  78. ncbi request reprint Factors that influence the results of salvage surgery in patients with chemorefractory germ cell carcinomas with elevated tumor markers
    Tomonori Habuchi
    Department of Urology, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Cancer 98:1635-42. 2003
    ....
  79. ncbi request reprint Differential profiling analysis of proteins involved in anti-proliferative effect of interferon-alpha on renal cell carcinoma cell lines by protein biochip technology
    Kogenta Nakamura
    Department of Urology, Aichi Medical University School of Medicine, Aichi 480 1195, Japan
    Int J Oncol 28:965-70. 2006
    ..Furthermore, the discovery of a susceptibility and or a inhibitory factor may eventually lead to the development of a novel drug targeting the respective factor for the improvement of anticancer chemotherapy...
  80. ncbi request reprint A clinical study of PMCJ-9 (Bacillus Calmette-Guérin Connaught strain) treatment of superficial bladder cancer and carcinoma in situ of the bladder
    Hideyuki Akaza
    Department of Urology, Institute of Clinical Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan
    Jpn J Clin Oncol 33:382-90. 2003
    ..In Japan, however, only BCG Tokyo 172 strain is commercially available. We therefore designed a clinical study of PMCJ-9 (BCG Connaught strain) for obtaining approval from Japanese Ministry of Health, Labor and Welfare...
  81. ncbi request reprint Bleomycin-induced pulmonary toxicity in chemotherapy for testicular cancer
    Koji Kawai
    Department of Urology, Institute of Clinical Medicine, University of Tsukuba, 1 1 1 Tennodai, Tsukuba City, Ibaraki 305, Japan
    Expert Opin Drug Saf 2:587-96. 2003
    ..This review will focus on bleomycin-induced pulmonary toxicity in chemotherapy for testicular cancer, followed by a brief review of recent basic understanding of the pathogenesis of lung fibrosis...
  82. ncbi request reprint Detection of cadherin-6 mRNA by nested RT-PCR as a potential marker for circulating cancer cells in renal cell carcinoma
    Toru Shimazui
    Department of Urology, Institute of Clinical Medicine, University of Tsukuba, Tsukuba City, Ibaraki 305 8575, Japan
    Int J Oncol 23:1049-54. 2003
    ..Detection of cadherin-6 mRNA in non-metastatic presurgical RCC patients suggests that careful follow-up study is necessary in these patients...
  83. ncbi request reprint Usefulness of urinary NMP22 to detect tumor recurrence of superficial bladder cancer after transurethral resection
    Naoto Miyanaga
    Department of Urology, University of Tsukuba, 1 1 1 Tennodai, Tsukuba 305 8575, Japan
    Int J Clin Oncol 8:369-73. 2003
    ..In a prospective study we compared the usefulness of urinary nuclear matrix protein 22 (NMP22) with that of urine cytology and other urinary markers in the monitoring of superficial bladder cancer after transurethral resection (TURBT)...
  84. ncbi request reprint Role of complex cadherins in cell-cell adhesion evaluated by spheroid formation in renal cell carcinoma cell lines
    Toru Shimazui
    Department of Urology, Institute of Clinical Medicine, University of Tsukuba, 1 1 1 Tennodai, Tsukuba, Ibaraki 305 8575, Japan
    Oncol Rep 11:357-60. 2004
    ..In conclusion, E-cadherin and cadherin-6 are shown to act in cell-cell adhesion whereas N-cadherin might play a somewhat different role from cell-cell adhesion in RCC cell lines...
  85. ncbi request reprint Paclitaxel, ifosfamide and cisplatin regimen is feasible for Japanese patients with advanced germ cell cancer
    Koji Kawai
    Institute of Clinical Medicine, Department of Urology, University of Tsukuba, 1 1 1 Tennodai, Tsukuba City, Ibaraki 305, Japan
    Jpn J Clin Oncol 33:127-31. 2003
    ..The purpose of this study was to assess the feasibility of a TIP regimen for Japanese patients with advanced germ cell cancer...
  86. ncbi request reprint Telomerase is upregulated in irreversible preneoplastic lesions during bladder carcinogenesis in rats
    Toru Shimazui
    Department of Urology, Institute of Clinical Medicine, University of Tsukuba, Tsukuba 305 8575
    Jpn J Cancer Res 93:495-500. 2002
    ....
  87. ncbi request reprint Type 1, P and S fimbriae, and afimbrial adhesin I are not essential for uropathogenic Escherichia coli to adhere to and invade bladder epithelial cells
    Jun Miyazaki
    Department of Infection Biology, Institute of Basic Medical Sciences, University of Tsukuba, 1 1 1 Tennodai, Tsukuba shi, Ibaraki 305 8575, Japan
    FEMS Immunol Med Microbiol 33:23-6. 2002
    ..In conclusion, this study demonstrates that type 1 fimbriae, P fimbriae, S fimbriae, and afimbrial adhesin I are not required for UPEC to adhere to and invade uroepithelial cells...
  88. ncbi request reprint How many uncomplicated male and female overactive bladder patients reveal detrusor overactivity during urodynamic study?
    Noritoshi Sekido
    Department of Urology, Institute of Clinical Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan
    Int J Urol 13:1276-9. 2006
    ..We retrospectively evaluated the incidence of detrusor overactivity (DO) in uncomplicated overactive bladder syndrome (OAB) patients...
  89. ncbi request reprint Trends in primary androgen depletion therapy for patients with localized and locally advanced prostate cancer: Japanese perspective
    Hideyuki Akaza
    Urology and Andrology, Functional and Regulatory Medical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki, 305 8575, Japan
    Cancer Sci 97:243-7. 2006
    ..The effectiveness of PADT in LAPC, in particular, is worthy of attention. There is a possibility that therapeutic strategies for LPC and LAPC may change dramatically in the near future...
  90. ncbi request reprint [Urological cancer]
    Naoto Miyanaga
    Dept of Urology, Institute of Clinical Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan
    Gan To Kagaku Ryoho 36:193-8. 2009
    ..Thus, new anticancer drugs such as taxanes and gemcitabine were added to cisplatin-based chemotherapy, and a treatment of urological cancer is progressing...
  91. ncbi request reprint Expression profile of N-cadherin differs from other classical cadherins as a prognostic marker in renal cell carcinoma
    Toru Shimazui
    Department of Urology, Institute of Clinical Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Ibaraki 305 8575, Japan
    Oncol Rep 15:1181-4. 2006
    ....
  92. ncbi request reprint Report from the 1st Japanese Urological Association-Japanese Society of Medical Oncology joint conference, 2006: 'A step towards better collaboration between urologists and medical oncologists'
    Hideyuki Akaza
    University of Tsukuba, Graduate School of Comprehensive Human Sciences, Tsukuba University Hospital, Japan
    Int J Urol 14:375-83. 2007
    ..This report presents a roundup of the 1st Japanese Urological Association-Japanese Society of Medical Oncology Joint Conference...
  93. ncbi request reprint Global update on defining and treating high-risk localized prostate cancer with leuprorelin: an Asian perspective
    Atsushi Mizokami
    Department of Integrative Cancer Therapy and Urology, Kanazawa University Graduate School of Medical Sciences, Japan
    BJU Int 99:6-9; discussion 17-8. 2007
    ....
  94. ncbi request reprint [A way of thinking of a MAB therapy for local/locally advanced prostate cancer: the theory and recent evaluation]
    Hideyuki Akaza
    Dep of Urology, Institute of Clinical Medicine, University of Tsukuba
    Gan To Kagaku Ryoho 34:657-69. 2007
    ....
  95. doi request reprint Evidence-based clinical practice Guidelines for Prostate Cancer (Summary - JUA 2006 Edition)
    Sadao Kamidono
    Int J Urol 15:1-18. 2008
  96. ncbi request reprint [Urology]
    Shiro Hinotsu
    Department of Urology, Institute of Clinical Medicine, University of Tsukuba, 1 1 1 Tennodai, Tsukuba, Ibaraki 305 8575, Japan
    Gan To Kagaku Ryoho 29:1549-69. 2002
    ..At minimum, we have clarified that large scale randomized trials have been conducted in Japan for both prostate cancer and bladder cancer...
  97. ncbi request reprint [Chemotherapy and radiotherapy for urological cancer]
    Naoto Miyanaga
    Dept of Urology, Institute of Clinical Medicine, University of Tsukuba
    Gan To Kagaku Ryoho 29:709-16. 2002
    ..Moreover, brachytherapy and proton and ion beam therapy are expected to prove useful in prostate cancer therapy...
  98. ncbi request reprint Molecular features of hormone-refractory prostate cancer cells by genome-wide gene expression profiles
    Kenji Tamura
    Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan
    Cancer Res 67:5117-25. 2007
    ..Our microarray analysis of HRPC cells should provide useful information to understand the molecular mechanism of HRPC progression and to identify molecular targets for development of HRPC treatment...
  99. ncbi request reprint Efficacy of primary hormonal therapy for patients with localized and locally advanced prostate cancer: a retrospective multicenter study
    Satoru Ueno
    Department of Integrative Cancer Therapy and Urology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
    Int J Urol 13:1494-500. 2006
    ..A retrospective review of patients with localized and locally advanced prostate cancer was performed to evaluate the efficacy of primary hormonal therapy and predict long-term prognosis in these patients...
  100. ncbi request reprint [Cancer chemotherapy in the future. Discussion]
    Hideyuki Akaza
    Gan To Kagaku Ryoho 30:1422-33. 2003
  101. ncbi request reprint [Usefulness and positioning of MAB therapy for prostate cancer]
    Hideyuki Akaza
    Dept of Urology, Institute of Clinical Medicine, University of Tsukuba
    Gan To Kagaku Ryoho 32:1507-20. 2005
    ....